Neurocrine Biosciences, Inc(NASDAQ:NBIX) 
Neurocrine Biosciences, Inc., a biopharmaceutical company, discovers, develops, and markets pharmaceutical products for the treatment of neurological, endocrine, and psychiatric-based diseases and disorders in the United States. The company offers INGREZZA, a VMAT2 inhibitor for the treatment of tar...
Website: http://www.neurocrine.com
Founded: 1992
Full Time Employees: 825
Sector: Healthcare
Industry: Biotechnology
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| Unit: USD | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-12-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-12-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-12-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 | 2013-12-31 | 2013-09-30 | 2013-06-30 | 2013-03-31 | 2012-12-31 | 2012-09-30 | 2012-06-30 | 2012-03-31 | 2011-12-31 | 2011-09-30 | 2011-06-30 | 2011-03-31 | 2010-12-31 | 2010-09-30 | 2010-06-30 | 2010-03-31 | 2009-12-31 | 2009-09-30 | 2009-06-30 | 2009-03-31 | 2008-12-31 | 2008-09-30 | 2008-06-30 | 2008-03-31 | 2007-12-31 | 2007-09-30 | 2007-06-30 | 2007-03-31 | 2006-12-31 | 2006-09-30 | 2006-06-30 | 2006-03-31 | 2005-12-31 | 2005-09-30 | 2005-06-30 | 2005-03-31 | 2004-12-31 | 2004-09-30 | 2004-06-30 | 2004-03-31 | 2003-12-31 | 2003-09-30 | 2003-06-30 | 2003-03-31 | 2002-12-31 | 2002-09-30 | 2002-06-30 | 2002-03-31 |
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revenues: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net product sales | 811,000,000 | 798,300,000 | 789,900,000 | 682,000,000 | 563,700,000 | 621,200,000 | 616,600,000 | 583,800,000 | 509,000,000 | 507,200,000 | 491,800,000 | 446,300,000 | 415,300,000 | 259,075,000 | 379,300,000 | 352,000,000 | 305,000,000 | 196,650,000 | 288,800,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
collaboration revenues | 3,500,000 | 7,200,000 | 5,000,000 | 5,500,000 | 8,900,000 | 4,550,000 | 5,500,000 | 6,400,000 | 6,300,000 | 4,625,000 | 7,000,000 | 6,400,000 | 5,100,000 | 10,100,000 | 8,600,000 | 26,200,000 | 5,600,000 | 8,725,000 | 7,200,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total revenues | 814,500,000 | 805,500,000 | 794,900,000 | 687,500,000 | 572,600,000 | 627,700,000 | 622,100,000 | 590,200,000 | 515,300,000 | 515,200,000 | 498,800,000 | 452,700,000 | 420,400,000 | 412,000,000 | 387,900,000 | 378,200,000 | 310,600,000 | 312,000,000 | 296,000,000 | 288,900,000 | 236,600,000 | 247,900,000 | 258,500,000 | 302,400,000 | 237,100,000 | 244,010,000 | 222,094,000 | 183,580,000 | 138,403,000 | 131,492,000 | 151,757,000 | 96,905,000 | 71,086,000 | 94,517,000 | 60,774,000 | 6,335,000 | 15,000,000 | 19,769,000 | 730,000 | 729,000 | 730,000 | 730,000 | 21,947,000 | 9,357,000 | 10,569,000 | 11,267,000 | 11,110,000 | 41,634,000 | 12,157,000 | 12,512,000 | 13,657,000 | 14,448,000 | 4,643,000 | 753,000 | 740,000 | 733,000 | 733,000 | 747,000 | 729,000 | 761,000 | 734,000 | 1,751,000 | 532,000 | 540,000 | 48,000 | 104,000 | 9,440,000 | 1,074,000 | 9,244,000 | 19,476,000 | 14,111,000 | 64,745,000 | 33,169,000 | 11,864,000 | 18,485,000 | 34,701,000 | 15,049,000 | 16,941,000 | |||||||||||||||||||
yoy | 42.25% | 28.33% | 27.78% | 16.49% | 11.12% | 21.84% | 24.72% | 30.37% | 22.57% | 25.05% | 28.59% | 19.70% | 35.35% | 32.05% | 31.05% | 30.91% | 31.28% | 25.86% | 14.51% | -4.46% | -0.21% | 1.59% | 16.39% | 64.72% | 71.31% | 85.57% | 46.35% | 89.44% | 94.70% | 39.12% | 149.71% | 1429.68% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | -24.12% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | -96.67% | -92.21% | -93.09% | -93.52% | 97.54% | -77.53% | -13.06% | -9.95% | -18.65% | 188.16% | 161.84% | 1561.62% | 1745.54% | 1871.08% | 533.42% | 0.80% | 1.51% | -3.68% | -0.14% | -57.34% | 37.03% | 40.93% | 1429.17% | 1583.65% | -94.36% | -49.72% | -99.48% | -99.47% | -33.10% | -98.34% | -72.13% | 64.16% | -23.66% | 86.58% | 120.41% | -29.97% | ||||||||||||||||
qoq | 1.12% | 1.33% | 15.62% | 20.07% | -8.78% | 0.90% | 5.40% | 14.54% | 0.02% | 3.29% | 10.18% | 7.68% | 2.04% | 6.21% | 2.56% | 21.76% | -0.45% | 5.41% | 2.46% | 22.10% | -4.56% | -4.10% | -14.52% | 27.54% | -2.83% | 9.87% | 20.98% | 32.64% | 5.26% | -13.35% | 56.60% | 36.32% | -24.79% | 55.52% | 859.34% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | 0.14% | -0.14% | 0.00% | -96.67% | 134.55% | -11.47% | -6.20% | 1.41% | -73.32% | 242.47% | -2.84% | -8.38% | -5.47% | 211.18% | 516.60% | 1.76% | 0.95% | 0.00% | -1.87% | 2.47% | -4.20% | 3.68% | -58.08% | 229.14% | -1.48% | 1025.00% | -53.85% | -98.90% | 778.96% | -88.38% | -52.54% | 38.02% | -78.21% | 95.20% | 179.58% | -35.82% | -46.73% | 130.59% | -11.17% | |||||||||||||||
operating expenses: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cost of revenues | 13,800,000 | 17,600,000 | 14,000,000 | 11,300,000 | 9,200,000 | 9,300,000 | 8,000,000 | 9,200,000 | 7,500,000 | 8,500,000 | 11,200,000 | 11,500,000 | 8,500,000 | 7,700,000 | 6,100,000 | 4,800,000 | 4,600,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
research and development | 296,200,000 | 258,200,000 | 250,000,000 | 244,300,000 | 263,200,000 | 185,600,000 | 195,000,000 | 191,100,000 | 159,400,000 | 137,500,000 | 142,200,000 | 145,800,000 | 139,500,000 | 118,000,000 | 107,700,000 | 135,900,000 | 102,200,000 | 87,400,000 | 92,700,000 | 74,800,000 | 73,200,000 | 66,700,000 | 69,100,000 | 80,900,000 | 58,300,000 | 55,425,000 | 45,278,000 | 61,687,000 | 37,652,000 | 39,107,000 | 35,482,000 | 36,988,000 | 48,947,000 | 25,614,000 | 22,463,000 | 21,868,000 | 51,882,000 | 22,583,000 | 20,942,000 | 26,863,000 | 23,903,000 | 21,809,000 | 24,388,000 | 18,719,000 | 16,575,000 | 15,498,000 | 12,194,000 | 10,161,000 | 8,572,000 | 8,918,000 | 9,490,000 | 10,527,000 | 10,313,000 | 9,097,000 | 9,860,000 | 8,818,000 | 9,388,000 | 8,002,000 | 7,456,000 | 8,176,000 | 7,317,000 | 8,065,000 | 8,227,000 | 7,283,000 | 7,576,000 | 6,753,000 | 7,401,000 | 10,808,000 | 10,848,000 | 11,885,000 | 12,993,000 | 16,186,000 | 14,227,000 | 24,340,000 | 19,795,000 | 18,789,000 | 19,061,000 | 18,608,000 | 25,223,000 | 26,112,000 | 27,735,000 | 24,765,000 | 26,627,000 | 29,633,000 | 25,603,000 | 33,404,000 | 32,305,000 | 22,969,000 | 26,388,000 | 39,087,000 | 37,537,000 | 48,324,000 | 41,565,000 | 24,231,000 | 23,096,000 | 20,047,000 | |
acquired in-process research and development | 21,200,000 | 17,000,000 | 300,000 | 100,000 | 3,000,000 | 1,000,000 | 2,500,000 | 6,000,000 | 143,900,000 | 100,300,000 | 5,000,000 | 118,500,000 | 46,000,000 | 36,191,000 | 5,000,000 | 113,081,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
selling, general, and administrative | 318,500,000 | 301,800,000 | 291,600,000 | 286,300,000 | 276,500,000 | 287,800,000 | 234,300,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale of business, net of transaction costs | -28,600,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total operating expenses | 621,100,000 | 594,600,000 | 555,900,000 | 541,900,000 | 549,000,000 | 485,700,000 | 438,300,000 | 444,800,000 | 416,000,000 | 364,900,000 | 357,600,000 | 379,100,000 | 534,600,000 | 308,600,000 | 300,100,000 | 323,500,000 | 307,500,000 | 348,300,000 | 251,500,000 | 226,100,000 | 205,100,000 | 176,100,000 | 302,800,000 | 225,800,000 | 178,200,000 | 195,289,000 | 131,996,000 | 149,119,000 | 239,400,000 | 109,621,000 | 97,434,000 | 98,757,000 | 108,533,000 | 82,683,000 | 66,769,000 | 63,603,000 | 79,932,000 | 46,251,000 | 38,436,000 | 41,828,000 | 35,857,000 | 30,748,000 | 35,844,000 | 25,322,000 | 22,057,000 | 20,468,000 | 16,857,000 | 14,361,000 | 12,725,000 | 12,260,000 | 12,735,000 | 13,897,000 | 13,705,000 | 13,365,000 | 13,319,000 | 11,949,000 | 13,059,000 | 10,663,000 | 11,194,000 | 11,061,000 | 10,573,000 | 13,786,000 | 11,982,000 | 10,533,000 | 10,922,000 | 9,720,000 | 10,456,000 | 16,576,000 | 19,871,000 | 31,444,000 | 16,465,000 | 20,851,000 | 22,513,000 | 129,126,000 | 29,366,000 | 27,596,000 | 27,378,000 | 25,703,000 | 41,270,000 | 38,508,000 | 47,070,000 | 38,705,000 | 39,624,000 | 39,421,000 | 31,211,000 | 39,669,000 | 37,732,000 | 28,438,000 | 31,671,000 | ||||||||
operating income | 193,400,000 | 210,900,000 | 239,000,000 | 145,600,000 | 23,600,000 | 142,000,000 | 183,800,000 | 145,400,000 | 99,300,000 | 150,300,000 | 141,200,000 | 73,600,000 | -114,200,000 | 103,400,000 | 87,800,000 | 54,700,000 | 3,100,000 | -36,300,000 | 44,500,000 | 62,800,000 | 31,500,000 | 71,800,000 | -44,300,000 | 76,600,000 | 58,900,000 | 48,721,000 | 90,098,000 | 34,461,000 | -100,997,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
yoy | 719.49% | 48.52% | 30.03% | 0.14% | -76.23% | -5.52% | 30.17% | 97.55% | -186.95% | 45.36% | 60.82% | 34.55% | -3783.87% | -384.85% | 97.30% | -12.90% | -90.16% | -150.56% | -200.45% | -18.02% | -46.52% | 47.37% | -149.17% | 122.28% | -158.32% | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
qoq | -8.30% | -11.76% | 64.15% | 516.95% | -83.38% | -22.74% | 26.41% | 46.42% | -33.93% | 6.44% | 91.85% | -164.45% | -210.44% | 17.77% | 60.51% | 1664.52% | -108.54% | -181.57% | -29.14% | 99.37% | -56.13% | -262.08% | -157.83% | 30.05% | 20.89% | -45.92% | 161.45% | -134.12% | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
operating margin % | 23.74% | 26.18% | 30.07% | 21.18% | 4.12% | 22.62% | 29.55% | 24.64% | 19.27% | 29.17% | 28.31% | 16.26% | -27.16% | 25.10% | 22.63% | 14.46% | 1.00% | -11.63% | 15.03% | 21.74% | 13.31% | 28.96% | -17.14% | 25.33% | 24.84% | 19.97% | 40.57% | 18.77% | -72.97% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | NaN% | NaN% | NaN% | NaN% | 0% | NaN% | NaN% | NaN% | 0% | NaN% | NaN% | NaN% | NaN% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% |
other income: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unrealized gain on equity investments | 25,300,000 | 2,700,000 | 30,600,000 | -30,600,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
investment income and other | 28,100,000 | 25,800,000 | 22,200,000 | 20,600,000 | 21,700,000 | 17,125,000 | 23,400,000 | 22,800,000 | 23,400,000 | 20,000,000 | 15,600,000 | 12,000,000 | 9,800,000 | 8,400,000 | 200,000 | 1,600,000 | 1,000,000 | 700,000 | 800,000 | 900,000 | 1,400,000 | 1,600,000 | 2,700,000 | 3,600,000 | 4,700,000 | 5,229,000 | 4,797,000 | 4,607,000 | 4,576,000 | 4,700,000 | 4,113,000 | 3,347,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total other income | 53,400,000 | 28,500,000 | 52,800,000 | 13,900,000 | 20,600,000 | 6,500,000 | -46,800,000 | -64,800,000 | 47,900,000 | -25,600,000 | 48,000,000 | 10,900,000 | -12,400,000 | 10,100,000 | 18,300,000 | -5,300,000 | 6,600,000 | 17,630,000 | -4,371,000 | -4,940,000 | -5,130,000 | -2,717,000 | 1,606,000 | 1,592,000 | 1,549,000 | 1,548,000 | 1,593,000 | 1,433,000 | 1,409,000 | 1,335,000 | 1,096,000 | 1,024,000 | 982,000 | 980,000 | 883,000 | 888,000 | 875,000 | 925,000 | 900,000 | 908,000 | 884,000 | 879,000 | 906,000 | 884,000 | 942,000 | 880,000 | 943,000 | 784,500 | 867,000 | 738,000 | 1,533,000 | -541,000 | 1,861,000 | -2,007,000 | -854,000 | -315,000 | 619,000 | 1,586,000 | 1,184,000 | 1,554,000 | 1,551,000 | 1,053,000 | 1,815,000 | 1,693,000 | 686,000 | 1,030,000 | 648,000 | 517,000 | 647,000 | 1,382,000 | 2,258,000 | 2,353,000 | |||||||||||||||||||||||||
income before provision for income taxes | 246,800,000 | 239,400,000 | 291,800,000 | 159,500,000 | 14,700,000 | 80,850,000 | 190,300,000 | 98,600,000 | 198,200,000 | 115,600,000 | 121,600,000 | 117,900,000 | 97,900,000 | -23,300,000 | -13,800,000 | 30,500,000 | 57,500,000 | 27,200,000 | 41,700,000 | -57,100,000 | 83,200,000 | 38,900,000 | 38,638,000 | 58,407,000 | 52,091,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
provision for income taxes | 48,900,000 | 85,700,000 | 82,300,000 | 52,000,000 | 6,800,000 | 21,300,000 | 60,500,000 | 33,600,000 | 50,500,000 | 32,500,000 | 26,100,000 | 28,900,000 | 29,400,000 | -6,400,000 | -6,500,000 | 8,000,000 | 15,200,000 | -4,900,000 | -306,200,000 | 500,000 | 3,600,000 | 1,500,000 | 4,638,000 | 4,618,000 | 753,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income | 197,900,000 | 153,700,000 | 209,500,000 | 107,500,000 | 7,900,000 | 103,100,000 | 129,800,000 | 65,000,000 | 43,400,000 | 147,700,000 | 83,100,000 | 95,500,000 | -76,600,000 | 89,000,000 | 68,500,000 | -16,900,000 | 13,900,000 | -7,300,000 | 22,500,000 | 42,300,000 | 32,100,000 | 347,900,000 | -57,600,000 | 79,600,000 | 37,400,000 | 34,000,000 | 53,789,000 | 51,338,000 | -102,115,000 | 18,078,000 | 50,764,000 | -5,913,000 | -41,818,000 | 6,894,000 | -11,125,000 | -59,985,000 | -78,326,000 | -44,659,000 | -36,887,000 | -40,280,000 | -19,264,000 | -29,315,000 | -34,435,000 | -23,987,000 | -1,192,000 | -19,444,000 | -15,875,000 | -13,381,000 | -11,842,000 | -10,642,000 | -11,131,000 | -12,242,000 | -12,075,000 | 9,490,000 | -3,078,000 | -501,000 | -886,000 | 1,331,000 | 31,382,000 | 1,976,000 | 2,882,000 | 2,487,000 | 3,333,000 | -5,152,000 | -8,636,000 | -7,916,000 | -8,177,000 | -15,280,000 | -19,665,000 | -28,854,000 | -17,711,000 | -20,971,000 | -21,077,000 | -127,975,000 | -27,240,000 | -26,364,000 | -25,720,000 | -14,712,000 | -39,143,000 | -27,449,000 | -25,901,000 | -23,908,000 | 26,151,000 | -5,604,000 | -18,830,000 | -20,615,000 | -1,647,000 | -11,131,000 | -12,380,000 | 3,193,000 | -9,834,000 | -10,225,000 | -13,390,000 | -38,787,000 | -20,234,000 | -19,751,000 | -15,764,000 |
yoy | 2405.06% | 49.08% | 61.40% | 65.38% | -81.80% | -30.20% | 56.20% | -31.94% | -156.66% | 65.96% | 21.31% | -665.09% | -651.08% | -1319.18% | 204.44% | -139.95% | -56.70% | -102.10% | -139.06% | -46.86% | -14.17% | 923.24% | -207.09% | 55.05% | -136.63% | 88.07% | 5.96% | -968.22% | 144.19% | 162.23% | -556.31% | -90.14% | -46.61% | -115.44% | -69.84% | 48.92% | 306.59% | 52.34% | 7.12% | 67.92% | 1516.11% | 50.77% | 116.91% | 79.26% | -89.93% | 82.71% | 42.62% | 9.30% | -1.93% | -212.14% | 261.63% | 2343.51% | 1262.87% | 613.00% | -109.81% | -125.35% | -130.74% | -46.48% | 841.55% | -138.35% | -133.37% | -131.42% | -140.76% | -66.28% | -56.08% | -72.57% | -53.83% | -27.14% | -6.70% | -77.45% | -34.98% | -20.46% | -18.05% | 769.87% | -30.41% | -3.95% | -0.70% | -38.46% | -249.68% | 389.81% | 37.55% | 15.97% | -1687.80% | -49.65% | 52.10% | -745.63% | -83.25% | 8.86% | -7.54% | -108.23% | -51.40% | -48.23% | -15.06% | ||||
qoq | 28.76% | -26.63% | 94.88% | 1260.76% | -92.34% | -20.57% | 99.69% | 49.77% | -70.62% | 77.74% | -12.98% | -224.67% | -186.07% | 29.93% | -505.33% | -221.58% | -290.41% | -132.44% | -46.81% | 31.78% | -90.77% | -703.99% | -172.36% | 112.83% | 10.00% | -36.79% | 4.77% | -150.27% | -664.86% | -64.39% | -958.52% | -85.86% | -706.59% | -161.97% | -81.45% | -23.42% | 75.39% | 21.07% | -8.42% | 109.09% | -34.29% | -14.87% | 43.56% | 1912.33% | -93.87% | 22.48% | 18.64% | 13.00% | 11.28% | -4.39% | -9.08% | 1.38% | -227.24% | -408.32% | 514.37% | -43.45% | -166.57% | -95.76% | 1488.16% | -31.44% | 15.88% | -25.38% | -164.69% | -40.34% | 9.10% | -3.19% | -46.49% | -22.30% | -31.85% | 62.92% | -15.55% | -0.50% | -83.53% | 369.81% | 3.32% | 2.50% | 74.82% | -62.41% | 42.60% | 5.98% | 8.34% | -191.42% | -566.65% | -70.24% | -8.66% | 1151.67% | -85.20% | -10.09% | -487.72% | -132.47% | -3.82% | -23.64% | -65.48% | 91.69% | 2.45% | 25.29% | |
net income margin % | 24.30% | 19.08% | 26.36% | 15.64% | 1.38% | 16.43% | 20.86% | 11.01% | 8.42% | 28.67% | 16.66% | 21.10% | -18.22% | 21.60% | 17.66% | -4.47% | 4.48% | -2.34% | 7.60% | 14.64% | 13.57% | 140.34% | -22.28% | 26.32% | 15.77% | 13.93% | 24.22% | 27.96% | -73.78% | 13.75% | 33.45% | -6.10% | -58.83% | 7.29% | -18.31% | -946.88% | NaN% | -Infinity% | NaN% | NaN% | -128.43% | -Infinity% | NaN% | NaN% | -6.03% | -Infinity% | NaN% | NaN% | NaN% | -1457.81% | -1526.89% | -1676.99% | -1654.11% | 43.24% | -32.90% | -4.74% | -7.86% | 11.98% | 75.38% | 16.25% | 23.03% | 18.21% | 23.07% | -110.96% | -1146.88% | -1069.73% | -1115.55% | -2084.58% | -2632.53% | -3958.02% | -2327.33% | -2857.08% | -1203.71% | -24055.45% | -5044.44% | -54925.00% | -24730.77% | -155.85% | -3644.60% | -296.94% | -132.99% | -169.43% | 40.39% | -16.90% | -158.72% | -111.52% | -4.75% | -73.97% | -73.08% | Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% |
foreign currency translation adjustments, net of tax | -100,000 | 1,600,000 | 800,000 | 1,500,000 | -3,600,000 | 2,900,000 | 100,000 | -500,000 | 1,700,000 | -1,400,000 | 900,000 | 1,200,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unrealized gain on available-for-sale debt securities, net of tax | -12,700,000 | -900,000 | 2,700,000 | 1,700,000 | -5,100,000 | 9,100,000 | 884,500 | 961,000 | 878,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
comprehensive income | 185,200,000 | 153,600,000 | 210,200,000 | 111,000,000 | 11,100,000 | 94,400,000 | 141,800,000 | 64,200,000 | 39,700,000 | 156,400,000 | 82,500,000 | 97,100,000 | -71,400,000 | 95,100,000 | 66,700,000 | -19,800,000 | 6,300,000 | -9,400,000 | 22,200,000 | 42,000,000 | 31,300,000 | 15,300,000 | -59,000,000 | 85,600,000 | 34,600,000 | 33,807,000 | 54,750,000 | 52,216,000 | -2,805,971 | 51,517,000 | 9,469,000 | -2,916,000 | -517,000 | -926,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
earnings per share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic | 1.97 | 0.818 | 2.11 | 1.09 | 0.08 | 0.593 | 1.28 | 0.64 | 0.43 | 0.263 | 0.85 | 0.98 | -0.79 | 0.173 | 0.72 | -0.18 | 0.15 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
diluted | 1.91 | 0.798 | 2.04 | 1.06 | 0.08 | 0.573 | 1.24 | 0.63 | 0.42 | 0.253 | 0.82 | 0.95 | -0.79 | 0.168 | 0.69 | -0.18 | 0.14 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
weighted-average shares outstanding: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic | 100.5 | 99.4 | 99 | 99.7 | 101.1 | 100.8 | 99.8 | 97.9 | 97.6 | 97.1 | 95.8 | 95.6 | 95.3 | 93.1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
diluted | 103.4 | 102.5 | 101 | 102.5 | 104.3 | 103.9 | 103.6 | 101.1 | 100.2 | 97.1 | 99 | 95.6 | 97.6 | 97.8 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
charges associated with convertible senior notes | -49,700,000 | -88,700,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unrealized loss on equity investments | -6,700,000 | -8,800,000 | -16,900,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total other expense | -8,900,000 | -78,000,000 | 22,500,000 | -14,000,000 | -4,300,000 | -6,550,000 | -12,800,000 | -20,000,000 | -10,083,000 | -31,691,000 | -1,597,000 | -2,997,750 | -3,559,000 | -4,061,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
selling, general and administrative | 242,000,000 | 243,100,000 | 218,900,000 | 204,200,000 | 221,800,000 | 242,700,000 | 182,900,000 | 186,300,000 | 182,800,000 | 200,700,000 | 156,500,000 | 154,600,000 | 143,200,000 | 129,000,000 | 106,500,000 | 112,500,000 | 96,500,000 | 117,800,000 | 63,212,750 | 84,489,000 | 80,824,000 | 87,538,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unrealized gain on equity securities | -19,900,000 | 7,200,000 | 11,100,000 | -7,400,000 | 19,900,000 | 11,300,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unrealized gain on debt securities available-for-sale, net of tax | -900,000 | -3,200,000 | 7,000,000 | 800,000 | 700,000 | 4,000,000 | -350,000 | -300,000 | -300,000 | 450,000 | -1,400,000 | 6,000,000 | -2,800,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest expense | -1,100,000 | -1,100,000 | -1,100,000 | -1,300,000 | -1,100,000 | -1,100,000 | -1,200,000 | -2,200,000 | -2,600,000 | -6,600,000 | -6,600,000 | -6,200,000 | -6,400,000 | -7,800,000 | -8,500,000 | -8,300,000 | -8,200,000 | -8,130,000 | -8,038,000 | -7,942,000 | -7,853,000 | -7,763,000 | -7,672,000 | -7,591,000 | -7,504,000 | -7,419,000 | -7,337,000 | -4,767,000 | -1,437,250 | -1,914,000 | -1,914,000 | -1,921,000 | -636,250 | -827,000 | -848,000 | -870,000 | -893,000 | -917,000 | -943,000 | -969,000 | -996,000 | -1,024,000 | -1,054,000 | -1,084,000 | -226,750 | -722,000 | -185,000 | 2,000 | -136,000 | -118,000 | -175,000 | -91,000 | -101,000 | ||||||||||||||||||||||||||||||||||||||||||||
unrealized gain on equity security investments | 1,600,000 | -150,000 | -40,100,000 | 37,300,000 | 2,200,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income before benefit from income taxes | 34,500,000 | 21,400,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
benefit from income taxes | -8,900,000 | 7,500,000 | -479,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on extinguishment of convertible senior notes | -70,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income before (benefit from) provision for income taxes | -103,300,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(benefit from) provision for income taxes | -26,700,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unrealized loss on debt securities available-for-sale, net of tax | -3,075,000 | -1,800,000 | -2,900,000 | -7,600,000 | -800,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cost of sales | 4,100,000 | 4,200,000 | 3,100,000 | 2,900,000 | 2,900,000 | 2,700,000 | 2,400,000 | 2,100,000 | 2,462,000 | 2,229,000 | 1,608,000 | 1,129,000 | 1,534,000 | 1,551,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unrealized loss on equity securities | -1,875,000 | -8,200,000 | -3,050,000 | -7,000,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income per share | 0.258 | 0.24 | 0.45 | 0.34 | 3.74 | -0.62 | 0.86 | 0.4 | 0.37 | 0.59 | 0.56 | -1.12 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
weighted-average common shares outstanding, basic | 99.5 | 100.4 | 97.7 | 95.8 | 94.6 | 94.7 | 94.6 | 94.2 | 93.3 | 93 | 92.6 | 91,627 | 91,859 | 91,389 | 90,235 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
weighted-average common shares outstanding, diluted | 102.5 | 103.7 | 101 | 98.9 | 97.9 | 97.7 | 97.7 | 98.2 | 93.3 | 98.2 | 97 | 95,732 | 96,074 | 94,779 | 95,386 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
product sales | 266,800,000 | 231,000,000 | 241,300,000 | 254,100,000 | 267,600,000 | 231,100,000 | 237,831,000 | 198,094,000 | 180,544,000 | 136,431,000 | 130,326,000 | 111,291,000 | 96,905,000 | 71,086,000 | 64,517,000 | 45,774,000 | 6,335,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
collaboration revenue | 22,100,000 | 5,600,000 | 6,600,000 | 4,400,000 | 34,800,000 | 6,000,000 | 6,179,000 | 24,000,000 | 3,036,000 | 1,972,000 | 1,166,000 | 40,466,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unrealized gain on restricted equity securities | 700,000 | 20,965,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unrealized losses on equity securities | -16,500,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unrealized loss on restricted equity securities | -7,182,000 | -28,450,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unrealized gain on investment in restricted equity securities | 1,680,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss before benefit from income taxes | -102,594,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
unrealized gain on available-for-sale securities, net of tax | 1,699,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
comprehensive loss | -100,416,000 | -5,025,000 | -43,665,000 | 5,578,000 | -10,946,000 | -60,463,000 | -78,243,000 | -44,790,000 | -37,035,000 | -40,131,000 | -18,475,000 | -29,683,000 | -34,640,000 | -24,212,000 | -1,094,000 | -10,327,500 | -15,956,000 | -13,313,000 | -12,041,000 | -8,863,750 | -11,096,000 | -12,242,000 | -12,117,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
weighted-average common shares outstanding, basic and diluted | 91,056 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
sales, general and administrative | 68,980,000 | 60,401,000 | 60,915,000 | 58,636,000 | 56,309,000 | 43,873,000 | 41,674,000 | 10,786,000 | 9,571,000 | 8,807,000 | 8,317,000 | 7,095,000 | 16,047,000 | 12,396,000 | 19,335,000 | 13,940,000 | 12,997,000 | 9,788,000 | 5,608,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income from operations | 21,871,000 | 54,323,000 | -1,852,000 | -37,447,000 | 11,834,000 | -5,995,000 | -57,268,000 | -79,932,000 | -46,251,000 | -38,436,000 | -41,828,000 | -20,857,000 | -30,748,000 | -35,844,000 | -25,322,000 | -2,288,000 | -20,468,000 | -16,857,000 | -14,361,000 | -12,725,000 | -11,530,000 | -12,006,000 | -13,167,000 | -12,975,000 | 8,582,000 | -3,962,000 | -1,380,000 | -1,792,000 | 447,000 | 30,440,000 | 1,096,000 | 1,939,000 | -129,000 | 2,466,000 | -5,890,000 | -10,169,000 | -8,980,000 | -9,723,000 | -15,843,000 | -19,124,000 | -30,715,000 | -15,704,000 | -20,117,000 | -20,762,000 | -128,594,000 | -28,826,000 | -27,548,000 | -27,274,000 | -16,263,000 | -40,196,000 | -29,264,000 | -27,594,000 | -24,594,000 | 25,121,000 | -6,252,000 | -19,347,000 | -21,184,000 | -3,031,000 | -13,389,000 | -14,730,000 | -17,371,000 | -13,574,000 | -12,490,000 | -15,352,000 | -41,273,000 | -22,501,000 | -22,020,000 | -17,821,000 | |||||||||||||||||||||||||||||
net income per common share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic | -29.77 | 560 | 150 | -50 | -10 | -10 | 20 | 570 | 40 | 50 | -50 | 60 | -615 | -1,030 | 12.5 | 710 | -457.5 | -660 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
diluted | -29.78 | 520 | 150 | -50 | -10 | -10 | 30 | 560 | 40 | 50 | -50 | 60 | -615 | -1,030 | 12.5 | 680 | -457.5 | -660 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shares used in the calculation of net income per common share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic | 22,516,000 | 90,555,000 | 264,000 | 66,342,000 | 66,309,000 | 63,409,000 | 28,000 | 55,248,000 | 55,209,000 | 54,983,000 | 13,032,500 | 54,844,000 | 9,416,000 | 37,868,000 | 9,171,250 | 36,707,000 | 7,611,750 | 30,522,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
diluted | 23,818,000 | 96,798,000 | 1,591,000 | 66,342,000 | 66,309,000 | 63,409,000 | 38,000 | 56,378,000 | 56,434,000 | 56,114,000 | 13,032,500 | 55,648,000 | 9,416,000 | 37,868,000 | 9,498,000 | 38,406,000 | 7,611,750 | 30,522,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other comprehensive income: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net unrealized gain on available-for-sale securities | -51,500 | 753,000 | 888,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cost of product sales | 854,000 | 950,000 | 760,000 | 433,000 | 61,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred gain on real estate | 183,000 | 201,000 | 183,000 | 183,000 | 879,000 | 879,000 | 863,000 | 853,000 | 854,000 | 853,000 | 838,000 | 828,000 | 829,000 | 830,000 | 812,000 | 805,000 | 805,000 | 804,000 | 789,000 | 781,000 | 781,000 | 782,000 | 766,000 | 759,000 | 759,000 | 758,000 | 744,000 | 736,000 | 737,000 | 736,000 | 722,000 | 715,000 | 715,000 | 694,000 | 695,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net loss per common share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted | -70 | -470 | -425 | -130 | -680 | -900 | -277.5 | -430 | -460 | -220 | -177.5 | -400 | -280 | -10 | -140 | -210 | -180 | -170 | -132.5 | -170 | -180 | -180 | -277.5 | -210 | -690 | -680 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shares used in the calculation of net loss per common share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted | 90,100,000 | 89,526,000 | 21,973,500 | 88,325,000 | 88,063,000 | 87,283,000 | 21,664,750 | 86,784,000 | 86,694,000 | 86,497,000 | 20,981,750 | 85,856,000 | 85,518,000 | 80,349,000 | 18,512,500 | 75,948,000 | 75,879,000 | 70,260,000 | 16,717,000 | 67,199,000 | 66,799,000 | 66,600,000 | 54,836,000 | 46,618,000 | 199,000 | 39,096,000 | 39,046,000 | 38,669,000 | 50,000 | 38,446,000 | 38,421,000 | 38,330,000 | 53,000 | 37,990,000 | 37,969,000 | 37,908,000 | 37,764,000 | 37,355,000 | 36,647,000 | 36,598,000 | 93,000 | 36,427,000 | 36,368,000 | 35,527,000 | 32,342,603 | 32,053 | 30,789,000 | 30,433,000 | 30,384,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
other comprehensive loss: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
investment income | 2,932,000 | 2,323,000 | 2,019,000 | 1,169,000 | 727,000 | 716,000 | 705,000 | 680,000 | 737,000 | 584,000 | 581,000 | 506,000 | 257,000 | 197,000 | 176,000 | 167,000 | 89,000 | 85,000 | 93,000 | 121,000 | 103,000 | 130,000 | 123,000 | 115,000 | 121,000 | 85,250 | 102,000 | 119,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net unrealized gains on available-for-sale securities | -1,847,000 | -1,316,000 | 179,000 | -478,000 | 83,000 | -131,000 | -148,000 | 149,000 | 789,000 | -225,000 | 98,000 | -70,000 | -81,000 | 68,000 | 14,000 | 35,000 | -21,000 | 162,000 | -16,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
license fees and milestones | 3,750,000 | 15,000,000 | 3,750,000 | 15,000,000 | 3,331,250 | 9,238,000 | 3,357,000 | 730,000 | 547,500 | 730,000 | 730,000 | 730,000 | 797,250 | 729,000 | 730,000 | 1,730,000 | 125,000 | 500,000 | 1,702,750 | 726,000 | 727,000 | 5,358,000 | 21,836,000 | 55,448,000 | 25,448,000 | 6,448,000 | 12,450,750 | 26,096,000 | 12,388,000 | 7,326,500 | 11,319,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other income, net: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale/disposal of assets | 1,750 | 5,000 | 2,000 | -9,000 | 14,000 | 3,000 | 9,000 | 1,000 | 5,000 | -10,000 | -1,000 | 6,000 | 19,000 | 13,000 | 7,000 | 25,000 | 58,000 | 86,000 | 18,000 | 80,000 | 92,000 | 34,000 | 53,000 | 115,000 | 2,893,000 | 571,000 | 21,000 | 141,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
general and administrative | 28,050,000 | 23,668,000 | 17,494,000 | 14,965,000 | 11,954,000 | 8,939,000 | 11,456,000 | 6,603,000 | 5,482,000 | 4,970,000 | 4,663,000 | 4,200,000 | 4,153,000 | 3,342,000 | 3,245,000 | 3,370,000 | 3,392,000 | 3,311,000 | 3,324,000 | 3,131,000 | 3,671,000 | 2,668,000 | 3,825,000 | 2,809,000 | 3,156,000 | 3,323,000 | 3,635,000 | 3,116,000 | 3,199,000 | 2,841,000 | 2,966,000 | 4,827,000 | 4,195,000 | 4,105,750 | 3,472,000 | 4,665,000 | 8,286,000 | 6,265,000 | 5,427,000 | 5,469,000 | 5,283,000 | 5,419,000 | 5,296,000 | 4,744,000 | 3,586,000 | 3,253,000 | 3,151,000 | 2,731,000 | |||||||||||||||||||||||||||||||||||||||||||||||||
license fees | 4,942,250 | 19,769,000 | 547,250 | 729,000 | 730,000 | 730,000 | 11,319,000 | 6,667,000 | 436,750 | 581,000 | 583,000 | 583,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other income | 15,000 | 3,000 | 15,000 | -5,000 | 4,000 | 2,000 | 5,000 | 2,000 | 5,000 | 2,000 | 5,000 | 18,000 | 5,000 | 8,000 | 996,000 | 35,000 | 24,000 | 1,188,000 | 111,000 | -558,000 | -283,000 | 250 | 2,000 | 48,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net unrealized losses on available-for-sale securities | -83,000 | -205,000 | -199,000 | -42,000 | -40,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
sponsored research and development | 13,959,000 | 1,369,000 | 1,540,000 | 2,029,000 | 1,873,000 | 2,396,000 | 2,919,000 | 3,274,000 | 4,419,000 | 5,210,000 | 1,286,000 | 23,000 | 11,000 | 3,000 | 3,000 | 17,000 | -1,000 | 32,000 | 4,000 | 12,000 | 19,000 | 13,000 | 21,000 | 86,000 | 213,000 | 348,000 | 277,000 | 5,878,000 | 753,000 | 1,297,000 | 2,721,000 | 4,416,000 | 10,676,000 | 8,605,000 | 2,506,000 | 5,369,000 | 15,048,000 | 17,580,000 | 30,725,000 | 1,652,000 | 3,574,000 | 3,180,000 | 3,958,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
cease-use expense | 957,000 | 135,000 | -7,000 | -87,000 | 76,000 | 100,000 | 147,000 | 4,828,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
milestones and license fees | 7,988,000 | 7,988,000 | 9,029,000 | 9,238,000 | 9,237,000 | 39,238,000 | 9,238,000 | 9,238,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
investment income and (expense) | 120,000 | 183,000 | 118,000 | -65,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cease use expense | 100,250 | 120,000 | 134,000 | 1,464,500 | 89,000 | 941,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income per common share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted | -90 | -190 | -390 | -510 | -740 | -460 | -550 | -550 | -3,360 | -720 | -730 | -690 | -150 | -510 | -175 | -50 | -310 | -350 | -0.268 | -0.31 | -430 | -650 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shares used in the calculation of net income per common share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted | 90,100,000 | 89,526,000 | 21,973,500 | 88,325,000 | 88,063,000 | 87,283,000 | 21,664,750 | 86,784,000 | 86,694,000 | 86,497,000 | 20,981,750 | 85,856,000 | 85,518,000 | 80,349,000 | 18,512,500 | 75,948,000 | 75,879,000 | 70,260,000 | 16,717,000 | 67,199,000 | 66,799,000 | 66,600,000 | 54,836,000 | 46,618,000 | 199,000 | 39,096,000 | 39,046,000 | 38,669,000 | 50,000 | 38,446,000 | 38,421,000 | 38,330,000 | 53,000 | 37,990,000 | 37,969,000 | 37,908,000 | 37,764,000 | 37,355,000 | 36,647,000 | 36,598,000 | 93,000 | 36,427,000 | 36,368,000 | 35,527,000 | 32,342,603 | 32,053 | 30,789,000 | 30,433,000 | 30,384,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
deferred gain on sale of real estate | 715,000 | 521,000 | 694,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
investment income and | 679,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
grant revenue | 2,250 | 9,000 | 18,000 | 27,000 | 27,000 | 18,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other income and | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on auction rate securities | -286,750 | 71,000 | 230,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest income | 157,250 | 99,000 | 176,000 | 354,000 | 1,972,000 | 2,442,000 | 2,758,000 | 2,662,000 | 1,645,000 | 2,080,000 | 1,713,000 | 1,601,000 | 1,724,750 | 2,102,000 | 2,444,000 | 2,353,000 | 2,599,000 | 3,724,000 | 2,201,000 | 2,564,000 | 2,458,000 | 2,282,000 | 2,045,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total other income net | 392,000 | 1,546,000 | 563,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on auction rate securities | -1,448,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest income and other income | 643,250 | -93,000 | 1,060,000 | 1,606,000 | 1,717,250 | 2,413,000 | 2,032,000 | 2,424,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
sales force allowance | 8,240,000 | 8,240,000 | 8,000,000 | 8,000,000 | 5,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other expense | -118,000 | -472,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other income and (expense) | -9,250 | -26,000 | -11,000 | -1,000 | 30,750 | 19,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
grant income | 102,000 | 155,000 | 253,000 | 246,500 | 360,000 | 324,000 | 364,500 | 578,000 | 464,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income before income taxes | 429,250 | 26,151,000 | -5,604,000 | -20,537,000 | -1,649,000 | -11,131,000 | -8,323,250 | -9,831,000 | -10,223,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income taxes | 78,000 | -2,000 | 2,000 | 3,000 | 2,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
sales allowance | 1,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest income and | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income before income tax expense | -18,830,000 | -12,377,000 | -13,239,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income tax expense | 3,000 | 151,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income per share | 0.258 | 0.24 | 0.45 | 0.34 | 3.74 | -0.62 | 0.86 | 0.4 | 0.37 | 0.59 | 0.56 | -1.12 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted | -90 | -190 | -390 | -510 | -740 | -460 | -550 | -550 | -3,360 | -720 | -730 | -690 | -150 | -510 | -175 | -50 | -310 | -350 | -0.268 | -0.31 | -430 | -650 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shares used in the calculation of net income per share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted | 90,100,000 | 89,526,000 | 21,973,500 | 88,325,000 | 88,063,000 | 87,283,000 | 21,664,750 | 86,784,000 | 86,694,000 | 86,497,000 | 20,981,750 | 85,856,000 | 85,518,000 | 80,349,000 | 18,512,500 | 75,948,000 | 75,879,000 | 70,260,000 | 16,717,000 | 67,199,000 | 66,799,000 | 66,600,000 | 54,836,000 | 46,618,000 | 199,000 | 39,096,000 | 39,046,000 | 38,669,000 | 50,000 | 38,446,000 | 38,421,000 | 38,330,000 | 53,000 | 37,990,000 | 37,969,000 | 37,908,000 | 37,764,000 | 37,355,000 | 36,647,000 | 36,598,000 | 93,000 | 36,427,000 | 36,368,000 | 35,527,000 | 32,342,603 | 32,053 | 30,789,000 | 30,433,000 | 30,384,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
net income per common share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shares used in the calculation of net | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss per common share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
milestones | 62,500 | 250,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other income and (expenses) | 43,750 | -16,000 | 78,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
grant income and other revenues | 416,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other income and expenses | 113,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss per common share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted | -520 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shares used in the calculation of loss per common share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted | 90,100,000 | 89,526,000 | 21,973,500 | 88,325,000 | 88,063,000 | 87,283,000 | 21,664,750 | 86,784,000 | 86,694,000 | 86,497,000 | 20,981,750 | 85,856,000 | 85,518,000 | 80,349,000 | 18,512,500 | 75,948,000 | 75,879,000 | 70,260,000 | 16,717,000 | 67,199,000 | 66,799,000 | 66,600,000 | 54,836,000 | 46,618,000 | 199,000 | 39,096,000 | 39,046,000 | 38,669,000 | 50,000 | 38,446,000 | 38,421,000 | 38,330,000 | 53,000 | 37,990,000 | 37,969,000 | 37,908,000 | 37,764,000 | 37,355,000 | 36,647,000 | 36,598,000 | 93,000 | 36,427,000 | 36,368,000 | 35,527,000 | 32,342,603 | 32,053 | 30,789,000 | 30,433,000 | 30,384,000 |
Balance Sheets:
Quarterly
Annual
| Unit: USD | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-12-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-12-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-12-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 | 2013-12-31 | 2013-09-30 | 2013-06-30 | 2013-03-31 | 2012-12-31 | 2012-09-30 | 2012-06-30 | 2012-03-31 | 2011-12-31 | 2011-09-30 | 2011-06-30 | 2011-03-31 | 2010-12-31 | 2010-09-30 | 2010-06-30 | 2010-03-31 | 2009-12-31 | 2009-09-30 | 2009-06-30 | 2009-03-31 | 2008-12-31 | 2008-09-30 | 2008-06-30 | 2008-03-31 | 2007-12-31 | 2007-09-30 | 2007-06-30 | 2007-03-31 | 2006-12-31 | 2006-09-30 | 2006-06-30 | 2006-03-31 | 2005-12-31 | 2005-09-30 | 2005-06-30 | 2005-03-31 | 2004-12-31 | 2004-09-30 | 2004-06-30 | 2004-03-31 | 2003-12-31 | 2003-09-30 | 2003-06-30 | 2003-03-31 | 2002-12-31 | 2002-09-30 | 2002-06-30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current assets: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents | 713,000,000 | 340,200,000 | 264,000,000 | 194,100,000 | 233,000,000 | 349,100,000 | 139,700,000 | 396,300,000 | 251,100,000 | 293,700,000 | 160,200,000 | 103,800,000 | 262,900,000 | 212,200,000 | 163,300,000 | 270,200,000 | 340,800,000 | 311,100,000 | 368,000,000 | 352,600,000 | 187,100,000 | 425,300,000 | 415,100,000 | 187,000,000 | 112,279,000 | 166,637,000 | 140,985,000 | 72,778,000 | 141,714,000 | 195,734,000 | 166,422,000 | 175,311,000 | 254,712,000 | 267,818,000 | 309,498,000 | 64,087,000 | 83,267,000 | 99,761,000 | 86,246,000 | 115,301,000 | 74,195,000 | 66,378,000 | 132,070,000 | 170,262,000 | 31,014,000 | 29,046,000 | 37,445,000 | 105,532,000 | 44,789,000 | 34,889,000 | 44,313,000 | 31,555,000 | 63,754,000 | 44,488,000 | 42,018,000 | 76,940,000 | 50,107,000 | 39,516,000 | 18,838,000 | 24,393,000 | 54,051,000 | 77,330,000 | 95,120,000 | 52,224,000 | 37,329,000 | 35,316,000 | 38,615,000 | 51,665,000 | 68,467,000 | 80,125,000 | 91,917,000 | 107,639,000 | 99,664,000 | 50,350,000 | 51,485,000 | 78,457,000 | 80,981,000 | 75,760,000 | 86,168,000 | 101,494,000 | 49,948,000 | 75,384,000 | 48,499,000 | 44,570,000 | 61,027,000 | 84,694,000 | 22,735,000 | 38,009,000 | 105,854,000 | 123,820,000 | 34,896,000 | 68,411,000 | 56,626,000 | 47,856,000 | |
available-for-sale debt securities | 767,400,000 | 774,600,000 | 711,600,000 | 749,400,000 | 843,100,000 | 878,900,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts receivable | 686,800,000 | 728,000,000 | 595,700,000 | 516,000,000 | 479,100,000 | 481,100,000 | 468,200,000 | 450,700,000 | 439,300,000 | 417,800,000 | 387,600,000 | 391,600,000 | 350,000,000 | 301,200,000 | 279,000,000 | 263,500,000 | 185,500,000 | 163,800,000 | 158,500,000 | 147,800,000 | 157,100,000 | 156,900,000 | 148,400,000 | 148,600,000 | 126,575,000 | 115,318,000 | 95,357,000 | 71,964,000 | 56,240,000 | 54,097,000 | 42,646,000 | 44,624,000 | 31,127,000 | 29,818,000 | 6,074,000 | 5,219,000 | 11,280,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
inventory | 69,000,000 | 69,300,000 | 56,900,000 | 59,100,000 | 57,400,000 | 45,800,000 | 42,500,000 | 37,200,000 | 38,300,000 | 30,500,000 | 17,288,000 | 10,798,000 | 12,018,000 | 13,010,000 | 10,864,000 | 6,054,000 | 242,000 | 128,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
prepaid expenses | 170,700,000 | 178,100,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other current assets | 115,800,000 | 68,200,000 | 120,700,000 | 119,300,000 | 112,100,000 | 121,700,000 | 120,200,000 | 100,500,000 | 97,800,000 | 108,200,000 | 100,600,000 | 113,200,000 | 79,100,000 | 67,900,000 | 62,700,000 | 60,800,000 | 45,500,000 | 50,500,000 | 38,400,000 | 33,800,000 | 30,100,000 | 34,700,000 | 27,500,000 | 26,700,000 | 16,647,000 | 22,954,000 | 21,455,000 | 24,150,000 | 19,760,000 | 18,900,000 | 16,291,000 | 8,613,000 | 7,863,000 | 7,407,000 | 5,529,000 | 3,871,000 | 3,092,000 | 4,849,000 | 4,568,000 | 4,377,000 | 4,883,000 | 5,940,000 | 4,696,000 | 4,916,000 | 4,394,000 | 4,194,000 | 2,700,000 | 2,232,000 | 2,119,000 | 2,153,000 | 2,162,000 | 2,688,000 | 2,179,000 | 2,079,000 | 1,470,000 | 2,098,000 | 1,966,000 | 1,664,000 | 1,716,000 | 1,402,000 | 1,093,000 | 2,133,000 | 1,923,000 | 1,060,000 | 1,014,000 | 819,000 | 911,000 | 1,698,000 | 1,726,000 | 2,446,000 | 3,536,000 | 3,329,000 | 3,263,000 | 3,248,000 | 3,863,000 | 4,571,000 | 5,902,000 | 4,303,000 | 5,384,000 | 5,252,000 | 5,425,000 | 5,899,000 | 4,473,000 | 4,818,000 | 4,886,000 | 5,354,000 | 4,982,000 | 5,200,000 | 9,263,000 | 3,767,000 | 3,818,000 | 4,406,000 | |||
total current assets | 2,522,700,000 | 2,158,400,000 | 1,748,900,000 | 1,637,900,000 | 1,724,700,000 | 1,876,600,000 | 1,669,800,000 | 1,799,000,000 | 1,607,000,000 | 1,649,900,000 | 1,496,600,000 | 1,432,800,000 | 1,453,500,000 | 1,205,500,000 | 1,019,300,000 | 1,018,200,000 | 972,800,000 | 1,005,700,000 | 1,110,100,000 | 1,085,400,000 | 1,016,200,000 | 1,156,900,000 | 1,146,200,000 | 968,200,000 | 831,034,000 | 819,232,000 | 748,808,000 | 633,192,000 | 737,777,000 | 714,394,000 | 567,677,000 | 513,716,000 | 554,919,000 | 548,485,000 | 536,751,000 | 239,451,000 | 310,442,000 | 357,891,000 | 391,966,000 | 400,984,000 | 384,074,000 | 382,785,000 | 389,416,000 | 404,953,000 | 198,203,000 | 183,868,000 | 197,575,000 | 221,735,000 | 148,462,000 | 159,218,000 | 155,853,000 | 160,395,000 | 189,264,000 | 178,018,000 | 181,258,000 | 184,974,000 | 132,476,000 | 136,126,000 | 120,038,000 | 126,584,000 | 133,051,000 | 131,592,000 | 143,761,000 | 68,332,000 | 55,387,000 | 58,190,000 | 53,784,000 | 67,204,000 | 81,423,000 | 98,810,000 | 113,629,000 | 152,203,000 | 182,948,000 | 128,180,000 | 150,595,000 | 170,313,000 | 193,658,000 | 204,780,000 | 240,627,000 | 274,722,000 | 279,310,000 | 297,628,000 | 271,525,000 | 281,034,000 | 313,815,000 | 336,658,000 | 336,054,000 | 381,650,000 | |||||||
deferred tax assets | 320,300,000 | 368,500,000 | 536,800,000 | 499,400,000 | 485,700,000 | 454,400,000 | 419,500,000 | 378,200,000 | 362,600,000 | 383,200,000 | 379,000,000 | 337,400,000 | 305,900,000 | 319,400,000 | 328,400,000 | 325,300,000 | 315,100,000 | 310,400,000 | 316,100,000 | 325,600,000 | 319,400,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
right-of-use assets | 455,400,000 | 468,900,000 | 492,300,000 | 502,200,000 | 509,400,000 | 257,300,000 | 262,900,000 | 270,800,000 | 276,500,000 | 80,800,000 | 83,500,000 | 84,400,000 | 87,000,000 | 89,600,000 | 92,200,000 | 94,700,000 | 97,200,000 | 97,900,000 | 100,300,000 | 97,000,000 | 82,800,000 | 71,000,000 | 72,100,000 | 73,300,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
equity investments | 120,800,000 | 118,100,000 | 87,500,000 | 94,200,000 | 124,800,000 | 126,700,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
property and equipment | 89,800,000 | 97,300,000 | 91,700,000 | 87,000,000 | 82,600,000 | 80,000,000 | 80,100,000 | 75,300,000 | 70,800,000 | 68,800,000 | 65,600,000 | 62,800,000 | 58,600,000 | 60,900,000 | 66,800,000 | 63,900,000 | 58,600,000 | 51,100,000 | 50,000,000 | 45,300,000 | 44,600,000 | 43,000,000 | 44,600,000 | 41,900,000 | 41,914,000 | 40,302,000 | 39,623,000 | 36,661,000 | 33,869,000 | 28,618,000 | 18,775,000 | 11,825,000 | 10,811,000 | 9,140,000 | 6,954,000 | 7,144,000 | 6,271,000 | 6,180,000 | 5,811,000 | 3,897,000 | 3,432,000 | 2,874,000 | 2,802,000 | 2,543,000 | 2,507,000 | 2,292,000 | 2,239,000 | 1,798,000 | 1,771,000 | 1,739,000 | 1,876,000 | 1,784,000 | 1,900,000 | 2,034,000 | 1,861,000 | 1,837,000 | 1,586,000 | 1,687,000 | 1,263,000 | 1,309,000 | 1,532,000 | 1,827,000 | 2,085,000 | 2,236,000 | 2,695,000 | 3,395,000 | 4,183,000 | 5,075,000 | 6,191,000 | 77,309,000 | 79,434,000 | 80,672,000 | 82,598,000 | 84,631,000 | 86,524,000 | 88,882,000 | 91,378,000 | 93,868,000 | 96,693,000 | 97,363,000 | 99,307,000 | 98,937,000 | 99,811,000 | 101,238,000 | 102,166,000 | 98,985,000 | 93,957,000 | 79,044,000 | 56,236,000 | 58,289,000 | 48,407,000 | 14,372,000 | 14,102,000 | 13,708,000 | 13,037,000 |
other noncurrent assets | 59,500,000 | 20,300,000 | 21,600,000 | 15,300,000 | 15,500,000 | 61,600,000 | 57,800,000 | 50,900,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total assets | 4,631,500,000 | 4,265,700,000 | 3,889,800,000 | 3,687,700,000 | 3,718,700,000 | 3,535,000,000 | 3,305,000,000 | 3,472,400,000 | 3,251,400,000 | 2,848,200,000 | 2,613,100,000 | 2,359,800,000 | 2,368,700,000 | 2,143,400,000 | 2,005,700,000 | 2,144,500,000 | 2,072,500,000 | 2,017,300,000 | 1,956,400,000 | 1,846,400,000 | 1,734,700,000 | 1,502,600,000 | 1,515,600,000 | 1,361,900,000 | 1,306,040,000 | 1,179,935,000 | 1,066,861,000 | 957,723,000 | 993,151,000 | 933,746,000 | 841,317,000 | 806,360,000 | 817,591,000 | 772,496,000 | 754,086,000 | 289,364,000 | 365,086,000 | 399,161,000 | 429,838,000 | 459,332,000 | 474,785,000 | 492,436,000 | 511,205,000 | 527,779,000 | 243,033,000 | 257,751,000 | 269,539,000 | 279,296,000 | 154,676,000 | 165,967,000 | 174,813,000 | 183,924,000 | 195,979,000 | 193,251,000 | 202,087,000 | 210,141,000 | 138,368,000 | 149,028,000 | 127,405,000 | 133,997,000 | 144,424,000 | 149,933,000 | 155,044,000 | 79,883,000 | 70,818,000 | 75,908,000 | 86,869,000 | 101,028,000 | 118,182,000 | 207,733,000 | 225,670,000 | 243,884,000 | 276,654,000 | 317,498,000 | 341,864,000 | 363,715,000 | 389,677,000 | 404,131,000 | 442,543,000 | 477,403,000 | 483,123,000 | 500,969,000 | 475,512,000 | 486,368,000 | 519,217,000 | 552,619,000 | 546,479,000 | 577,269,000 | |||||||
liabilities and stockholders’ equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current liabilities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts payable and accrued liabilities | 674,300,000 | 584,300,000 | 489,500,000 | 475,200,000 | 461,600,000 | 392,700,000 | 358,500,000 | 417,200,000 | 448,800,000 | 503,000,000 | 391,600,000 | 355,700,000 | 347,600,000 | 297,800,000 | 265,700,000 | 235,900,000 | 225,800,000 | 205,900,000 | 190,900,000 | 171,900,000 | 168,700,000 | 170,500,000 | 137,100,000 | 125,900,000 | 141,285,000 | 102,357,000 | 95,027,000 | 68,280,000 | 86,377,000 | 72,022,000 | 61,031,000 | 45,650,000 | 53,520,000 | 37,289,000 | 26,809,000 | 17,294,000 | 15,663,000 | 13,910,000 | 15,428,000 | 17,233,000 | 16,791,000 | 18,091,000 | 17,716,000 | 18,733,000 | 29,573,000 | 27,119,000 | |||||||||||||||||||||||||||||||||||||||||||||||||
other current liabilities | 69,100,000 | 53,700,000 | 56,800,000 | 47,700,000 | 46,100,000 | 37,000,000 | 40,000,000 | 36,700,000 | 35,900,000 | 18,700,000 | 21,200,000 | 18,400,000 | 20,700,000 | 18,100,000 | 20,000,000 | 17,600,000 | 20,000,000 | 20,000,000 | 22,000,000 | 18,100,000 | 17,800,000 | 15,500,000 | 16,400,000 | 14,400,000 | 15,195,000 | 13,295,000 | 5,562,000 | 3,723,000 | 1,856,000 | 731,000 | 731,000 | 85,000 | 113,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total current liabilities | 743,400,000 | 638,000,000 | 546,300,000 | 522,900,000 | 507,700,000 | 429,700,000 | 398,500,000 | 712,900,000 | 654,800,000 | 691,600,000 | 582,500,000 | 374,100,000 | 537,700,000 | 485,100,000 | 285,700,000 | 253,500,000 | 245,800,000 | 225,900,000 | 212,900,000 | 190,000,000 | 186,500,000 | 611,000,000 | 573,000,000 | 140,300,000 | 565,287,000 | 115,652,000 | 100,589,000 | 72,003,000 | 88,233,000 | 456,400,000 | 61,762,000 | 46,466,000 | 54,426,000 | 38,141,000 | 27,721,000 | 23,563,000 | 30,414,000 | 26,666,000 | 26,899,000 | 23,276,000 | 25,715,000 | 19,822,000 | 17,553,000 | 15,187,000 | 15,664,000 | 14,045,000 | 12,053,000 | 10,608,000 | 11,699,000 | 13,321,000 | 14,573,000 | 13,878,000 | 15,646,000 | 23,113,000 | 29,152,000 | 36,631,000 | 47,110,000 | 48,444,000 | 49,990,000 | 49,028,000 | 52,777,000 | 53,184,000 | 52,123,000 | 18,630,000 | 19,961,000 | 24,044,000 | 33,017,000 | 32,536,000 | 26,094,000 | 18,975,000 | 19,494,000 | 17,972,000 | 29,907,000 | 20,021,000 | 18,943,000 | 17,823,000 | 20,116,000 | 21,267,000 | 23,932,000 | 32,757,000 | 33,693,000 | 35,039,000 | 40,294,000 | 47,182,000 | 59,585,000 | 72,112,000 | 67,503,000 | 97,536,000 | |||||||
noncurrent operating lease liabilities | 415,300,000 | 428,400,000 | 439,100,000 | 447,500,000 | 455,100,000 | 251,400,000 | 256,200,000 | 252,900,000 | 258,300,000 | 85,900,000 | 89,100,000 | 90,400,000 | 93,500,000 | 105,300,000 | 94,400,000 | 86,756,000 | 74,482,000 | 66,185,000 | 67,147,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other noncurrent liabilities | 219,700,000 | 195,700,000 | 210,100,000 | 181,600,000 | 166,200,000 | 135,000,000 | 141,100,000 | 120,500,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities | 1,378,400,000 | 1,262,100,000 | 1,195,500,000 | 1,152,000,000 | 1,129,000,000 | 816,100,000 | 795,800,000 | 1,086,300,000 | 1,019,400,000 | 846,100,000 | 760,100,000 | 675,300,000 | 660,900,000 | 598,800,000 | 582,300,000 | 753,400,000 | 698,500,000 | 671,300,000 | 677,200,000 | 640,800,000 | 608,500,000 | 698,300,000 | 684,400,000 | 661,600,000 | 669,117,000 | 605,420,000 | 583,155,000 | 548,448,000 | 512,386,000 | 486,233,000 | 463,881,000 | 441,873,000 | 445,453,000 | 424,984,000 | 408,848,000 | 42,223,000 | 50,209,000 | 47,510,000 | 48,800,000 | 46,373,000 | 50,331,000 | 45,493,000 | 44,265,000 | 43,049,000 | 34,334,000 | 33,714,000 | 32,694,000 | 32,239,000 | 34,266,000 | 36,675,000 | 38,797,000 | 38,971,000 | 41,607,000 | 49,946,000 | 57,354,000 | 66,307,000 | 78,287,000 | 91,279,000 | 101,847,000 | 111,003,000 | 125,079,000 | 133,286,000 | 142,632,000 | 63,162,000 | 66,864,000 | 74,833,000 | 79,521,000 | 81,917,000 | 81,408,000 | 144,086,000 | 145,829,000 | 145,218,000 | 157,957,000 | 72,544,000 | 72,815,000 | 72,012,000 | 74,961,000 | 77,655,000 | 80,771,000 | 93,573,000 | 93,019,000 | 97,229,000 | 103,493,000 | 111,648,000 | 125,390,000 | 140,055,000 | 134,938,000 | 151,864,000 | |||||||
stockholders’ equity: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value... | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
common stock, 0.001 par value... | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 92,000 | 92,000 | 92,000 | 91,000 | 91,000 | 91,000 | 90,000 | 90,000 | 89,000 | 88,000 | 88,000 | 88,000 | 87,000 | 87,000 | 87,000 | 87,000 | 86,000 | 86,000 | 86,000 | 85,000 | 76,000 | 76,000 | 76,000 | 76,000 | 67,000 | 67,000 | 67,000 | 67,000 | 66,000 | 66,000 | 66,000 | 66,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 44,000 | 39,000 | 39,000 | 39,000 | 39,000 | 39,000 | 38,000 | 38,000 | 38,000 | 38,000 | 38,000 | 38,000 | 38,000 | 38,000 | 38,000 | 38,000 | 37,000 | 37,000 | 37,000 | 37,000 | 37,000 | 36,000 | 36,000 | 36,000 | |||||||
additional paid-in capital | 2,792,200,000 | 2,696,300,000 | 2,597,200,000 | 2,531,900,000 | 2,554,600,000 | 2,623,200,000 | 2,555,300,000 | 2,496,400,000 | 2,382,000,000 | 2,308,500,000 | 2,241,900,000 | 2,170,500,000 | 2,122,400,000 | 2,054,300,000 | 1,999,800,000 | 1,947,700,000 | 2,011,400,000 | 1,974,000,000 | 1,929,400,000 | 1,897,800,000 | 1,849,700,000 | 1,874,300,000 | 1,842,200,000 | 1,796,900,000 | 1,768,118,000 | 1,739,517,000 | 1,703,458,000 | 1,681,244,000 | 1,660,361,000 | 1,645,311,000 | 1,626,752,000 | 1,608,778,000 | 1,572,765,000 | 1,553,718,000 | 1,540,498,000 | 1,381,938,000 | 1,371,432,000 | 1,363,416,000 | 1,355,768,000 | 1,347,558,000 | 1,340,579,000 | 1,333,385,000 | 1,318,742,000 | 1,312,321,000 | 1,035,205,000 | 1,031,029,000 | 1,027,881,000 | 1,024,780,000 | 886,101,000 | 884,355,000 | 879,983,000 | 876,678,000 | 873,981,000 | 872,383,000 | 870,895,000 | 869,479,000 | 784,811,000 | 783,882,000 | 782,933,000 | 782,376,000 | 781,607,000 | 780,652,000 | 779,755,000 | 778,909,000 | 757,002,000 | 746,178,000 | 744,479,000 | 743,438,000 | 741,568,000 | 739,761,000 | 738,011,000 | 735,731,000 | 733,542,000 | 730,386,000 | 727,812,000 | 724,412,000 | 721,930,000 | 719,405,000 | 716,540,000 | 711,023,000 | 691,717,000 | 682,339,000 | 676,682,000 | 674,925,000 | 674,034,000 | 671,543,000 | 670,183,000 | 668,713,000 | 622,526,000 | 620,724,000 | 432,279,000 | 428,286,000 | 422,205,000 | 421,507,000 | |
accumulated other comprehensive income | 13,100,000 | 13,200,000 | 12,500,000 | 9,000,000 | 5,800,000 | 14,500,000 | 2,500,000 | 3,300,000 | 7,000,000 | -1,700,000 | 400,000 | 700,000 | 1,000,000 | 1,800,000 | 3,200,000 | 4,600,000 | -1,400,000 | 1,413,000 | 1,606,000 | 645,000 | 19,000 | 696,000 | 691,000 | 694,000 | 1,243,000 | -1,510,000 | -233,000 | 272,000 | 634,000 | 324,000 | 99,000 | -1,908,000 | -1,112,000 | -2,296,000 | 2,024,000 | 1,664,000 | 2,544,000 | 4,416,000 | 3,544,000 | 2,372,000 | 461,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
retained earnings | 447,700,000 | 294,000,000 | 84,500,000 | 29,200,000 | 81,100,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total stockholders’ equity | 3,253,100,000 | 3,003,600,000 | 2,694,300,000 | 2,535,700,000 | 2,589,700,000 | 2,718,900,000 | 2,509,200,000 | 2,386,100,000 | 2,232,000,000 | 2,002,100,000 | 1,853,000,000 | 1,684,500,000 | 1,707,800,000 | 1,544,600,000 | 1,423,400,000 | 1,391,100,000 | 1,374,000,000 | 1,346,000,000 | 1,279,200,000 | 1,205,600,000 | 1,126,200,000 | 804,300,000 | 831,200,000 | 700,300,000 | 636,923,000 | 574,515,000 | 483,706,000 | 409,275,000 | 480,765,000 | 447,513,000 | 377,436,000 | 364,487,000 | 372,138,000 | 347,512,000 | 345,238,000 | 247,141,000 | 314,877,000 | 351,651,000 | 381,038,000 | 412,959,000 | 424,454,000 | 446,943,000 | 466,940,000 | 484,730,000 | 208,699,000 | 224,037,000 | 236,845,000 | 247,057,000 | 120,410,000 | 129,292,000 | 136,016,000 | 144,953,000 | 154,372,000 | 143,305,000 | 144,733,000 | 143,834,000 | 60,081,000 | 57,749,000 | 25,558,000 | 22,994,000 | 19,345,000 | 16,647,000 | 12,412,000 | 16,721,000 | 3,954,000 | 1,075,000 | 7,348,000 | 19,111,000 | 36,774,000 | 63,647,000 | 79,841,000 | 98,666,000 | 118,697,000 | 244,954,000 | 269,049,000 | 291,703,000 | 314,716,000 | 326,476,000 | 361,772,000 | 383,830,000 | 390,104,000 | 403,740,000 | 372,019,000 | 374,720,000 | 393,827,000 | 412,564,000 | 411,541,000 | 425,405,000 | |||||||
total liabilities and stockholders’ equity | 4,631,500,000 | 4,265,700,000 | 3,889,800,000 | 3,687,700,000 | 3,718,700,000 | 3,535,000,000 | 3,305,000,000 | 3,472,400,000 | 3,251,400,000 | 2,848,200,000 | 2,613,100,000 | 2,359,800,000 | 2,368,700,000 | 2,143,400,000 | 2,005,700,000 | 2,144,500,000 | 2,072,500,000 | 2,017,300,000 | 1,956,400,000 | 1,846,400,000 | 1,734,700,000 | 1,502,600,000 | 1,515,600,000 | 1,361,900,000 | 1,306,040,000 | 1,179,935,000 | 1,066,861,000 | 957,723,000 | 993,151,000 | 933,746,000 | 841,317,000 | 806,360,000 | 817,591,000 | 772,496,000 | 754,086,000 | 289,364,000 | 365,086,000 | 399,161,000 | 429,838,000 | 459,332,000 | 474,785,000 | 492,436,000 | 511,205,000 | 527,779,000 | 243,033,000 | 257,751,000 | 269,539,000 | 279,296,000 | 154,676,000 | 165,967,000 | 174,813,000 | 183,924,000 | 195,979,000 | 193,251,000 | 202,087,000 | 210,141,000 | 138,368,000 | 149,028,000 | 127,405,000 | 133,997,000 | 144,424,000 | 149,933,000 | 155,044,000 | 79,883,000 | 70,818,000 | 75,908,000 | 86,869,000 | 101,028,000 | 118,182,000 | 207,733,000 | 225,670,000 | 243,884,000 | 276,654,000 | 317,498,000 | 341,864,000 | 363,715,000 | 389,677,000 | 404,131,000 | 442,543,000 | 477,403,000 | 483,123,000 | 500,969,000 | 475,512,000 | 486,368,000 | 519,217,000 | 552,619,000 | 546,479,000 | 577,269,000 | |||||||
intangible assets | 35,700,000 | 37,200,000 | 36,400,000 | 36,500,000 | 34,500,000 | 33,500,000 | 34,300,000 | 35,500,000 | 34,900,000 | 36,900,000 | 37,200,000 | 37,200,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities and stockholders' equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(accumulated deficit) retained earnings | -5,300,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible senior notes | 170,100,000 | 169,900,000 | 169,700,000 | 169,400,000 | 169,200,000 | 169,000,000 | 377,700,000 | 335,100,000 | 330,700,000 | 326,300,000 | 322,000,000 | 425,000,000 | 419,500,000 | 408,807,000 | 403,589,000 | 398,466,000 | 393,435,000 | 388,496,000 | 378,885,000 | 374,209,000 | 369,618,000 | 365,110,000 | 360,681,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
debt securities available-for-sale | 899,200,000 | 814,300,000 | 780,500,000 | 801,400,000 | 816,500,000 | 790,800,000 | 726,400,000 | 587,200,000 | 485,000,000 | 394,700,000 | 370,500,000 | 613,900,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
equity security investments | 143,600,000 | 163,500,000 | 132,800,000 | 173,000,000 | 135,700,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated deficit | -48,700,000 | -113,700,000 | -157,100,000 | -304,800,000 | -387,900,000 | -483,400,000 | -406,800,000 | -495,800,000 | -564,300,000 | -547,400,000 | -635,800,000 | -628,500,000 | -651,000,000 | -693,300,000 | -725,400,000 | -1,073,300,000 | -1,015,700,000 | -1,095,300,000 | -1,132,700,000 | -1,166,700,000 | -1,220,489,000 | -1,271,827,000 | -1,177,755,000 | -1,195,833,000 | -1,246,597,000 | -1,240,684,000 | -1,198,866,000 | -1,205,760,000 | -1,194,635,000 | -1,134,650,000 | -1,056,324,000 | -1,011,665,000 | -974,778,000 | -934,498,000 | -915,234,000 | -885,919,000 | -851,484,000 | -827,497,000 | -826,305,000 | -806,861,000 | -790,986,000 | -777,605,000 | -765,763,000 | -755,121,000 | -743,990,000 | -731,748,000 | -719,673,000 | -729,163,000 | -726,085,000 | -725,584,000 | -724,698,000 | -726,029,000 | -757,411,000 | -759,387,000 | -762,269,000 | -764,756,000 | -768,089,000 | -762,937,000 | -754,301,000 | -746,385,000 | -738,208,000 | -722,928,000 | -703,263,000 | -674,409,000 | -656,698,000 | -635,727,000 | -614,650,000 | -486,675,000 | -459,435,000 | -433,071,000 | -407,351,000 | -392,639,000 | -353,496,000 | -326,047,000 | -300,146,000 | -276,238,000 | -302,389,000 | -296,785,000 | -277,955,000 | -257,340,000 | -255,693,000 | -244,562,000 | -232,182,000 | -235,375,000 | -225,541,000 | -215,316,000 | -163,139,000 | -142,905,000 | |||||||
convertible senior notes, at carrying value | 122,800,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible senior notes embedded derivative liability | 136,200,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
equity securities | 161,900,000 | 102,100,000 | 94,900,000 | 83,800,000 | 91,300,000 | 63,700,000 | 35,300,000 | 38,900,000 | 38,900,000 | 38,200,000 | 43,700,000 | 50,700,000 | 39,400,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other assets | 49,600,000 | 43,100,000 | 35,900,000 | 24,900,000 | 25,000,000 | 10,500,000 | 10,000,000 | 10,100,000 | 3,200,000 | 3,200,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other long-term liabilities | 106,300,000 | 68,600,000 | 88,500,000 | 41,300,000 | 29,700,000 | 17,100,000 | 28,000,000 | 19,700,000 | 12,300,000 | 8,300,000 | 29,000,000 | 21,300,000 | 9,700,000 | 4,300,000 | 27,100,000 | 21,600,000 | 17,074,000 | 11,697,000 | 17,915,000 | 15,863,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
inventories | 28,800,000 | 31,700,000 | 33,400,000 | 35,100,000 | 37,000,000 | 29,300,000 | 29,000,000 | 25,500,000 | 28,300,000 | 30,100,000 | 28,000,000 | 20,600,000 | 22,000,000 | 21,200,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive loss | -1,700,000 | -1,100,000 | -2,700,000 | -7,900,000 | -14,000,000 | -12,200,000 | -9,300,000 | -233,000 | -1,932,000 | -2,056,000 | -2,809,000 | -3,697,000 | -1,850,000 | -534,000 | -713,000 | -235,000 | -318,000 | -187,000 | -39,000 | -188,000 | -977,000 | -609,000 | -404,000 | -179,000 | -9,000 | -44,000 | -44,000 | -2,000 | -143,000 | -127,000 | -87,000 | -159,000 | -19,000 | -50,000 | -1,438,000 | -1,570,000 | -1,744,000 | -1,376,000 | -328,000 | -1,310,000 | -1,184,000 | -1,504,000 | -2,329,000 | -2,147,000 | -3,190,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||
operating lease liabilities | 96,600,000 | 99,600,000 | 102,500,000 | 106,400,000 | 109,000,000 | 107,500,000 | 83,000,000 | 84,300,000 | 85,600,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other long-term assets | 4,400,000 | 1,400,000 | 3,200,000 | 3,400,000 | 3,600,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
debt securities available-for-sale, at fair value | 454,800,000 | 516,900,000 | 521,100,000 | 519,400,000 | 533,200,000 | 584,700,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restricted cash | 3,200,000 | 3,200,000 | 3,200,000 | 3,200,000 | 3,200,000 | 3,206,000 | 4,706,000 | 5,477,000 | 5,477,000 | 5,477,000 | 5,477,000 | 5,477,000 | 4,500,000 | 4,500,000 | 4,613,000 | 4,613,000 | 5,083,000 | 4,883,000 | 4,883,000 | 4,883,000 | 4,991,000 | 4,791,000 | 4,791,000 | 4,815,000 | 4,831,000 | 4,831,000 | 4,443,000 | 4,443,000 | 4,443,000 | 4,443,000 | 4,335,000 | 4,335,000 | 4,335,000 | 4,335,000 | 4,334,000 | 4,334,000 | 4,306,000 | 4,306,000 | 6,128,000 | 6,104,000 | 6,104,000 | 6,102,000 | 6,333,000 | 6,329,000 | 6,327,000 | 6,325,000 | 6,322,000 | 6,414,000 | 6,404,000 | 6,409,000 | 6,441,000 | 6,568,000 | 6,415,000 | 6,399,000 | 5,250,000 | 5,250,000 | 5,250,000 | 5,250,000 | 5,775,000 | 5,775,000 | 5,775,000 | 5,775,000 | 5,775,000 | 5,775,000 | 5,775,000 | ||||||||||||||||||||||||||||||
blank | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
marketable securities | 558,245,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
operating lease assets | 74,364,000 | 61,987,000 | 49,085,000 | 49,304,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restricted equity securities | 55,868,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
short-term investments in available-for-sale debt securities | 503,525,000 | 478,993,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term investments in available-for-sale debt securities | 204,793,000 | 146,503,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
investment in restricted equity securities | 48,915,000 | 77,365,000 | 56,400,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred rent | 18,114,000 | 12,107,000 | 5,326,000 | 3,107,000 | 3,135,000 | 3,163,000 | 1,693,000 | 1,305,000 | 1,462,000 | 1,590,000 | 1,704,000 | 1,817,000 | 1,711,000 | 1,789,000 | 1,852,000 | 1,817,000 | 1,877,000 | 1,916,000 | 1,942,000 | 1,988,000 | 1,982,000 | 1,955,000 | 1,916,000 | 1,878,000 | 1,840,000 | 2,023,000 | 1,959,000 | 1,880,000 | 1,800,000 | 1,698,000 | 1,628,000 | 1,512,000 | 1,413,000 | 1,425,000 | 1,252,000 | 1,079,000 | 906,000 | 706,000 | 756,000 | 433,000 | 110,000 | 2,740,000 | 2,645,000 | 2,551,000 | 2,438,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||
deferred gain on sale of real estate | 7,312,000 | 7,495,000 | 7,677,000 | 7,860,000 | 8,043,000 | 8,226,000 | 8,409,000 | 6,467,000 | 7,372,000 | 8,261,000 | 9,140,000 | 10,019,000 | 10,898,000 | 11,761,000 | 12,614,000 | 13,468,000 | 14,322,000 | 15,159,000 | 15,988,000 | 16,817,000 | 17,645,000 | 18,458,000 | 19,263,000 | 20,067,000 | 20,872,000 | 21,661,000 | 22,442,000 | 23,224,000 | 24,005,000 | 24,771,000 | 25,529,000 | 26,288,000 | 27,046,000 | 27,790,000 | 28,527,000 | 29,263,000 | 29,999,000 | 30,721,000 | 31,436,000 | 32,151,000 | 32,867,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
short-term investments, available for sale | 451,290,000 | 439,609,000 | 342,318,000 | 285,168,000 | 171,493,000 | 253,281,000 | 301,152,000 | 266,223,000 | 310,467,000 | 252,650,000 | 199,745,000 | 150,628,000 | 157,211,000 | 114,330,000 | 122,022,000 | 109,383,000 | 126,679,000 | 129,473,000 | 135,522,000 | 104,146,000 | 72,115,000 | 96,322,000 | 97,246,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term investments, available for sale | 176,689,000 | 185,257,000 | 249,388,000 | 276,319,000 | 37,686,000 | 30,207,000 | 27,178,000 | 49,460,000 | 101,986,000 | 114,172,000 | 115,452,000 | 67,148,000 | 65,282,000 | 51,320,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
short-term investments, available-for-sale | 509,199,000 | 261,217,000 | 243,200,000 | 215,522,000 | 224,083,000 | 304,996,000 | 162,795,000 | 100,950,000 | 109,259,000 | 78,996,000 | 72,814,000 | 16,135,000 | 14,152,000 | 14,710,000 | 12,006,000 | 16,824,000 | 19,984,000 | 42,106,000 | 79,721,000 | 74,483,000 | 95,812,000 | 88,334,000 | 101,623,000 | 124,018,000 | 148,151,000 | 162,995,000 | 223,120,000 | 215,454,000 | 194,769,000 | 226,337,000 | 240,102,000 | 239,653,000 | 303,802,000 | 333,724,000 | 347,314,000 | 318,957,000 | 237,918,000 | 239,828,000 | 218,281,000 | 239,614,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term investments, available-for-sale | 216,028,000 | 247,361,000 | 210,258,000 | 205,768,000 | 43,490,000 | 82,488,000 | 37,492,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenue | 10,231,000 | 10,231,000 | 10,231,000 | 10,231,000 | 10,231,000 | 10,231,000 | 10,231,000 | 10,231,000 | 10,231,000 | 10,231,000 | 10,231,000 | 10,231,000 | 10,231,000 | 10,231,000 | 10,231,000 | 10,231,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
commitments and contingencies | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of convertible senior notes | 383,647,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of cease-use liability | 62,000 | 121,000 | 181,000 | 243,000 | 236,000 | 265,000 | 259,000 | 234,000 | 428,000 | 481,000 | 556,000 | 479,000 | 467,000 | 454,000 | 441,000 | 428,000 | 416,000 | 409,000 | 402,000 | 496,000 | 589,000 | 280,000 | 273,000 | 269,000 | 264,000 | 1,604,000 | 2,004,000 | 2,701,000 | 3,385,000 | 4,047,000 | 4,450,000 | 4,369,000 | 4,289,000 | 8,898,000 | 15,414,000 | 15,202,000 | 7,870,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of deferred gain on sale of real estate | 731,000 | 731,000 | 731,000 | 731,000 | 3,552,000 | 3,526,000 | 3,500,000 | 3,475,000 | 3,449,000 | 3,423,000 | 3,398,000 | 3,373,000 | 3,348,000 | 3,324,000 | 3,299,000 | 3,275,000 | 3,251,000 | 3,227,000 | 3,203,000 | 3,179,000 | 3,156,000 | 3,133,000 | 3,110,000 | 3,087,000 | 3,064,000 | 3,042,000 | 3,019,000 | 2,997,000 | 2,975,000 | 2,953,000 | 2,931,000 | 2,910,000 | 2,888,000 | 2,867,000 | 2,846,000 | 2,826,000 | 2,805,000 | 2,784,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of deferred rent | 513,000 | 470,000 | 428,000 | 386,000 | 345,000 | 269,000 | 232,000 | 197,000 | 152,000 | 119,000 | 85,000 | 52,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cease-use liability | 544,000 | 617,000 | 649,000 | 713,000 | 809,000 | 1,555,000 | 1,670,000 | 1,770,000 | 2,086,000 | 2,211,000 | 2,334,000 | 2,451,000 | 2,566,000 | 2,680,000 | 2,789,000 | 2,893,000 | 2,996,000 | 3,097,000 | 2,269,000 | 2,190,000 | 2,259,000 | 2,328,000 | 5,335,000 | 5,704,000 | 6,150,000 | 6,580,000 | 4,487,000 | 5,093,000 | 6,163,000 | 7,241,000 | 8,378,000 | 2,750,000 | 3,016,000 | 7,527,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other liabilities | 113,000 | 113,000 | 113,000 | 113,000 | 113,000 | 113,000 | 221,000 | 221,000 | 220,000 | 245,000 | 260,000 | 260,000 | 260,000 | 260,000 | 260,000 | 260,000 | 152,000 | 152,000 | 152,000 | 152,000 | 152,000 | 151,000 | 124,000 | 125,000 | 124,000 | 101,000 | 101,000 | 1,481,000 | 1,436,000 | 1,498,000 | 1,346,000 | 2,835,000 | 3,134,000 | 3,961,000 | 4,455,000 | 4,636,000 | 4,710,000 | 5,085,000 | 5,939,000 | 5,663,000 | 5,693,000 | 6,259,000 | 5,634,000 | 8,413,000 | 5,736,000 | 5,249,000 | 4,799,000 | 4,516,000 | 4,353,000 | 3,997,000 | 3,989,000 | 3,936,000 | 3,109,000 | 2,009,000 | 1,845,000 | 1,534,000 | 1,051,000 | 972,000 | 1,176,000 | ||||||||||||||||||||||||||||||||||||
accounts payable | 852,000 | 5,085,000 | 1,719,000 | 1,762,000 | 2,122,000 | 2,561,000 | 1,197,000 | 1,035,000 | 1,270,000 | 246,000 | 900,000 | 846,000 | 818,000 | 101,000 | 1,097,000 | 1,348,000 | 1,460,000 | 911,000 | 1,416,000 | 1,420,000 | 596,000 | 1,111,000 | 766,000 | 932,000 | 507,000 | 810,000 | 912,000 | 640,000 | 539,000 | 2,188,000 | 1,501,000 | 1,752,000 | 2,551,000 | 1,599,000 | 2,988,000 | 2,739,000 | 1,408,000 | 3,776,000 | 3,213,000 | 3,447,000 | 5,391,000 | 2,910,000 | 1,295,000 | 1,912,000 | 2,717,000 | 2,163,000 | 3,669,000 | 1,445,000 | |||||||||||||||||||||||||||||||||||||||||||||||
accrued liabilities | 18,403,000 | 21,097,000 | 20,754,000 | 21,017,000 | 17,126,000 | 19,034,000 | 14,514,000 | 12,392,000 | 9,938,000 | 11,508,000 | 9,307,000 | 7,439,000 | 6,111,000 | 7,955,000 | 7,882,000 | 8,185,000 | 6,577,000 | 8,094,000 | 8,130,000 | 6,937,000 | 6,967,000 | 8,451,000 | 7,562,000 | 7,314,000 | 5,887,000 | 8,603,000 | 8,334,000 | 7,172,000 | 6,428,000 | 6,240,000 | 7,870,000 | 10,104,000 | 9,056,000 | 10,905,000 | 12,785,000 | 13,235,000 | 12,620,000 | 21,717,000 | 12,414,000 | 17,895,000 | 19,846,000 | 42,676,000 | 55,091,000 | 58,524,000 | 47,968,000 | 34,602,000 | 15,504,000 | 17,604,000 | |||||||||||||||||||||||||||||||||||||||||||||||
receivables under collaboration agreements | 15,083,000 | 30,030,000 | 75,000 | 38,000 | 8,000 | 1,369,000 | 1,539,000 | 1,809,000 | 22,397,000 | 2,912,000 | 3,281,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive gain | -277,000 | -207,000 | -126,000 | -194,000 | 5,000 | -48,000 | 1,209,000 | 1,038,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
receivables under collaboration agreements and other current assets | 2,919,000 | 1,873,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
receivables under collaborative agreements | 23,000 | 14,089,000 | 1,903,000 | 4,470,000 | 12,000 | 3,000 | 10,000 | 39,000 | 163,000 | 2,000 | 12,000 | 27,000 | 18,000 | 35,000 | 274,000 | 7,191,000 | 431,000 | 406,000 | 5,930,000 | 858,000 | 1,538,000 | 22,832,000 | 4,228,000 | 8,213,000 | 7,493,000 | 4,631,000 | 4,563,000 | 13,659,000 | 16,397,000 | 32,221,000 | 29,803,000 | 2,391,000 | 2,722,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term investments | 675,000 | 12,749,000 | 17,410,000 | 480,000 | 8,865,000 | 14,634,000 | 19,024,000 | 5,087,000 | 3,739,000 | 10,181,000 | 2,869,000 | 2,988,000 | 6,411,000 | 6,602,000 | 21,242,000 | 19,609,000 | 21,057,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of deferred revenues | 730,000 | 1,459,000 | 2,189,000 | 2,919,000 | 10,177,000 | 17,435,000 | 25,735,000 | 34,242,000 | 35,493,000 | 36,743,000 | 36,958,000 | 37,026,000 | 36,960,000 | 36,951,000 | 2,925,000 | 2,941,000 | 2,929,000 | 2,921,000 | 2,922,000 | 2,936,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenues | 728,000 | 1,460,000 | 2,189,000 | 2,919,000 | 10,907,000 | 18,895,000 | 27,924,000 | 37,162,000 | 46,400,000 | 55,637,000 | 8,027,000 | 8,757,000 | 9,486,000 | 10,216,000 | 10,946,000 | 11,676,000 | 2,926,000 | 2,919,000 | 2,919,000 | 2,928,000 | 36,000 | 9,000 | 36,000 | 976,000 | 1,453,000 | 10,419,000 | 6,537,000 | 10,896,000 | 16,344,000 | 21,991,000 | 27,674,000 | 37,787,000 | 36,438,000 | 47,916,000 | 49,666,000 | 51,416,000 | 47,583,000 | 57,381,000 | 833,000 | 8,219,000 | 2,623,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
short-term investments | 47,641,000 | 36,268,000 | 13,975,000 | 21,802,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other non-current assets | 1,399,000 | 1,246,000 | 2,736,000 | 3,102,000 | 3,918,000 | 4,446,000 | 4,594,000 | 4,709,000 | 5,437,000 | 5,495,000 | 5,270,000 | 5,391,000 | 5,708,000 | 5,448,000 | 5,543,000 | 4,731,000 | 4,629,000 | 4,401,000 | 4,321,000 | 3,986,000 | 3,732,000 | 3,774,000 | 4,024,000 | 1,371,000 | 10,057,000 | 6,863,000 | 4,343,000 | 3,721,000 | 3,611,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of long-term debt | 276,000 | 601,000 | 1,025,000 | 1,486,000 | 2,691,000 | 3,271,000 | 3,877,000 | 4,489,000 | 4,863,000 | 5,246,000 | 5,547,000 | 5,814,000 | 6,052,000 | 6,234,000 | 6,458,000 | 6,674,000 | 4,752,000 | 3,946,000 | 4,034,000 | 3,960,000 | 3,422,000 | 3,344,000 | 37,000 | 75,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
leaseback financing obligation | 108,745,000 | 108,745,000 | 108,745,000 | 108,745,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long–term investments | 21,255,000 | 21,593,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term deferred revenues | 12,405,000 | 13,135,000 | 13,865,000 | 14,595,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
prepaid royalty | 94,000,000 | 94,000,000 | 94,000,000 | 94,000,000 | 94,000,000 | 94,000,000 | 94,000,000 | 94,000,000 | 94,000,000 | 94,000,000 | 94,000,000 | 94,000,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term debt | 47,438,000 | 47,933,000 | 48,526,000 | 49,152,000 | 50,129,000 | 51,205,000 | 52,403,000 | 53,590,000 | 54,941,000 | 56,400,000 | 57,950,000 | 59,452,000 | 63,946,000 | 54,934,000 | 43,096,000 | 32,473,000 | 19,105,000 | 19,123,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
reclassification of share based compensation liability | 933,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred compensation | -95,000 | -198,000 | -312,000 | -424,000 | -550,000 | -667,000 | -784,000 | -891,000 | -1,008,000 | -1,124,000 | -1,361,000 | -1,481,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
notes receivable from stockholders | -69,000 | -69,000 | -69,000 | -69,000 | -139,000 | -139,000 | -139,000 | -139,000 | -208,000 | -208,000 | -208,000 | -277,000 | -381,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deposits and restricted cash | 5,250,000 | 18,244,000 | 17,694,000 | 17,551,000 | 25,539,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
prepaid royalties | 95,000,000 | 95,000,000 | 95,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restricted cash and other non-current assets | 29,739,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current portion of capital lease obligations | 2,939,000 | 2,179,000 | 1,881,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
capital lease obligations, net of current portion | 5,363,000 | 5,277,000 | 4,473,000 | 3,635,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
licensed technology and patent applications costs | 98,000 | 121,000 |
Cashflow Statements:
Quarterly
Annual
| Unit: USD | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-12-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-12-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-12-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 | 2013-12-31 | 2013-09-30 | 2013-06-30 | 2013-03-31 | 2012-12-31 | 2012-09-30 | 2012-06-30 | 2012-03-31 | 2011-12-31 | 2011-09-30 | 2011-06-30 | 2011-03-31 | 2010-12-31 | 2010-09-30 | 2010-06-30 | 2010-03-31 | 2009-12-31 | 2009-09-30 | 2009-06-30 | 2009-03-31 | 2008-12-31 | 2008-09-30 | 2008-06-30 | 2008-03-31 | 2007-12-31 | 2007-09-30 | 2007-06-30 | 2007-03-31 | 2006-12-31 | 2006-09-30 | 2006-06-30 | 2006-03-31 | 2005-12-31 | 2005-09-30 | 2005-06-30 | 2005-03-31 | 2004-12-31 | 2004-09-30 | 2004-06-30 | 2004-03-31 | 2003-12-31 | 2003-09-30 | 2003-06-30 | 2003-03-31 | 2002-12-31 | 2002-09-30 | 2002-06-30 | 2002-03-31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cash flows from operating activities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income | 209,500,000 | 107,500,000 | 7,900,000 | 103,100,000 | 129,800,000 | 65,000,000 | 43,400,000 | 147,700,000 | 83,100,000 | 95,500,000 | -76,600,000 | 89,000,000 | 68,500,000 | -16,900,000 | 13,900,000 | -7,300,000 | 22,500,000 | 42,300,000 | 32,100,000 | 347,900,000 | -57,600,000 | 79,600,000 | 37,400,000 | 34,000,000 | 18,078,000 | 9,490,000 | -3,078,000 | -501,000 | -886,000 | 1,331,000 | 31,382,000 | 1,976,000 | 2,882,000 | 2,487,000 | 3,333,000 | -5,152,000 | -8,636,000 | -15,280,000 | -19,665,000 | -28,854,000 | -17,711,000 | -20,971,000 | -21,077,000 | -127,975,000 | -39,143,000 | -27,449,000 | -25,901,000 | 26,151,000 | -5,604,000 | -18,830,000 | -1,647,000 | -11,131,000 | -12,380,000 | 3,193,000 | -9,834,000 | -10,225,000 | -13,390,000 | -19,751,000 | -15,764,000 | ||||||||||||||||||||||||||||||||||||
adjustments to reconcile net income to net cash from operating activities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stock-based compensation expense | 53,700,000 | 52,800,000 | 52,800,000 | 66,400,000 | 41,500,000 | 43,100,000 | 44,500,000 | 38,100,000 | 47,800,000 | 68,500,000 | 39,900,000 | 43,500,000 | 43,100,000 | 49,500,000 | 37,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
charges associated with convertible senior notes | 0 | 0 | 49,700,000 | 88,700,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
impairment charges associated with leased properties | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
depreciation | 6,700,000 | 6,300,000 | 6,600,000 | 6,200,000 | 5,600,000 | 6,400,000 | 5,300,000 | 4,900,000 | 4,600,000 | 4,200,000 | 4,100,000 | 3,900,000 | 4,000,000 | 3,900,000 | 3,300,000 | 3,000,000 | 2,800,000 | 2,600,000 | 2,500,000 | 2,200,000 | 2,200,000 | 2,100,000 | 2,100,000 | 2,544,000 | 2,505,000 | 2,442,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accretion of discount on available-for-sale debt securities | -2,700,000 | -3,400,000 | -4,600,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of intangible assets | 1,000,000 | 1,000,000 | 1,000,000 | 900,000 | 900,000 | 900,000 | 900,000 | 800,000 | 900,000 | 900,000 | 900,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
changes in fair values of equity investments | -30,600,000 | 6,700,000 | 30,600,000 | 1,900,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred income taxes | 168,300,000 | -37,400,000 | -13,700,000 | -31,300,000 | -34,900,000 | -41,300,000 | -15,600,000 | 20,600,000 | -4,200,000 | -41,500,000 | -31,600,000 | 13,500,000 | 9,000,000 | -3,100,000 | -300,000 | -4,700,000 | 5,700,000 | 9,500,000 | -6,200,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash lease expense | 6,600,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other | 200,000 | -7,400,000 | 7,900,000 | 20,600,000 | 300,000 | 200,000 | 3,400,000 | 12,300,000 | -6,500,000 | -4,300,000 | -2,400,000 | 1,100,000 | 700,000 | 1,500,000 | 800,000 | -3,300,000 | 2,100,000 | 3,000,000 | 2,600,000 | 2,000,000 | 1,000,000 | 300,000 | 400,000 | -38,000 | 676,000 | 0 | 116,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
change in operating assets and liabilities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts receivable | -132,300,000 | -79,700,000 | -36,900,000 | 2,000,000 | -12,900,000 | -17,600,000 | -11,300,000 | -21,400,000 | -30,400,000 | 4,200,000 | -41,700,000 | -46,500,000 | -22,200,000 | -15,500,000 | -78,000,000 | -21,700,000 | -5,300,000 | -10,700,000 | 9,300,000 | -200,000 | -8,500,000 | 300,000 | -22,100,000 | -11,257,000 | -18,795,000 | -23,393,000 | -15,724,000 | -2,143,000 | -11,451,000 | 1,978,000 | -13,497,000 | -1,309,000 | -23,744,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
inventory | -12,300,000 | 2,100,000 | -1,700,000 | -11,600,000 | -3,300,000 | -5,300,000 | 1,100,000 | -800,000 | -3,900,000 | -6,490,000 | 1,220,000 | 599,000 | -1,753,000 | 383,000 | -636,000 | -782,000 | -114,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts payable and accrued liabilities | 55,800,000 | 15,500,000 | 12,400,000 | 67,700,000 | 39,400,000 | -59,500,000 | -18,600,000 | -83,000,000 | 124,400,000 | 16,200,000 | 6,700,000 | 37,600,000 | 32,800,000 | 32,700,000 | 11,500,000 | 19,100,000 | 8,700,000 | 18,000,000 | 11,000,000 | -1,200,000 | 33,200,000 | 11,100,000 | -16,200,000 | 41,611,000 | 4,605,000 | 24,306,000 | -16,567,000 | 8,646,000 | 11,304,000 | 12,143,000 | -7,870,000 | 16,231,000 | 10,480,000 | 7,554,000 | -6,927,000 | 3,520,000 | -306,000 | 3,531,000 | -2,347,000 | 5,884,000 | 2,284,000 | 2,219,000 | -546,000 | 1,547,000 | 1,922,000 | 1,356,000 | -1,127,000 | -923,000 | -554,000 | 1,496,000 | -968,000 | -541,000 | 1,189,000 | 794,000 | -1,999,000 | 1,234,000 | 82,000 | 1,852,000 | -3,019,000 | 167,000 | 1,434,000 | 845,000 | -1,461,000 | -943,000 | -2,485,000 | 249,000 | -897,000 | -3,269,000 | -201,000 | 1,946,000 | -11,465,000 | 8,199,000 | 1,631,000 | 1,753,000 | -1,717,000 | 199,000 | -1,805,000 | 442,000 | -4,551,000 | 3,251,000 | 375,000 | -1,017,000 | -6,504,000 | -4,336,000 | 3,060,000 | -18,467,000 | -11,406,000 | ||||||||
income tax assets and liabilities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other assets and liabilities | -42,100,000 | 23,000,000 | 2,500,000 | 36,200,000 | -18,800,000 | -3,900,000 | -2,800,000 | 51,600,000 | -50,900,000 | 71,400,000 | -24,300,000 | 3,500,000 | -18,500,000 | 8,500,000 | -10,700,000 | 12,500,000 | -27,200,000 | 3,800,000 | 1,700,000 | 6,100,000 | -28,300,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash flows from operating activities | 227,500,000 | 102,000,000 | 64,800,000 | 242,500,000 | 158,000,000 | 64,600,000 | 130,300,000 | 123,500,000 | 212,000,000 | 179,600,000 | -125,200,000 | 143,000,000 | 98,800,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash flows from investing activities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of available-for-sale debt securities | -408,500,000 | -315,100,000 | -273,200,000 | -311,800,000 | -231,189,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
sales and maturities of available-for-sale debt securities | 225,000,000 | 298,600,000 | 298,100,000 | 250,800,000 | 149,083,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
capital expenditures | -7,600,000 | -8,900,000 | -5,700,000 | -4,300,000 | -4,500,000 | -4,500,000 | -400,000 | -4,700,000 | -1,300,000 | -2,812,000 | -3,544,000 | -4,453,000 | -3,939,000 | -6,010,000 | -12,359,000 | -4,643,000 | -1,800,000 | -2,377,000 | -2,804,000 | -397,000 | -1,362,000 | -347,000 | -777,000 | -2,243,000 | -741,000 | -828,000 | -316,000 | -510,000 | -280,000 | -439,000 | -269,000 | -649,000 | -255,000 | -191,000 | -31,000 | -264,000 | -59,000 | -42,000 | -335,000 | -190,000 | -404,000 | -40,000 | -562,000 | -128,000 | -20,000 | -12,000 | -86,000 | 0 | 0 | -10,000 | -1,000 | -24,000 | -137,000 | -30,000 | -874,000 | -281,000 | -133,000 | -318,000 | -108,000 | -65,000 | -86,000 | -282,000 | -2,020,000 | -722,000 | -2,973,000 | -1,670,000 | -1,078,000 | -1,514,000 | -5,595,000 | -7,120,000 | -16,381,000 | -24,051,000 | -17,436,000 | -10,899,000 | -20,870,000 | -1,234,000 | -1,306,000 | -1,525,000 | -2,077,000 | -392,000 | |||||||||||||||
free cash flows | -48,100,000 | -4,700,000 | 56,100,000 | 98,900,000 | 82,800,000 | 84,400,000 | -17,900,000 | 114,200,000 | 36,900,000 | 99,741,000 | 94,282,000 | 59,713,000 | -116,430,000 | 44,444,000 | 56,558,000 | 15,836,000 | -40,286,000 | 38,198,000 | -12,114,000 | -48,636,000 | -78,719,000 | -31,972,000 | -31,787,000 | -16,578,000 | -29,952,000 | -16,031,000 | -18,888,000 | 13,451,000 | -18,463,000 | -15,748,000 | -12,368,000 | -10,614,000 | -10,022,000 | -11,070,000 | -10,811,000 | -10,124,000 | 1,853,000 | -8,951,000 | -8,638,000 | -7,068,000 | -11,608,000 | 10,997,000 | 2,210,000 | -6,038,000 | -8,600,000 | -17,315,000 | 10,155,000 | 69,193,000 | -13,973,000 | -11,111,000 | -13,632,000 | -14,414,000 | -16,436,000 | -14,726,000 | -15,885,000 | -28,448,000 | -4,359,000 | -21,819,000 | -18,862,000 | -14,918,000 | -16,885,000 | -34,024,000 | -30,463,000 | -21,072,000 | -25,877,000 | 43,927,000 | -28,586,000 | -27,493,000 | -34,651,000 | -14,005,000 | -54,510,000 | -49,969,000 | -19,078,000 | -17,274,000 | -38,543,000 | 61,584,000 | -34,093,000 | -16,230,000 | -21,857,000 | -12,485,000 | |||||||||||||||
cash flows from investing activities | -196,700,000 | -29,000,000 | 14,200,000 | -68,300,000 | 24,700,000 | -28,200,000 | -55,000,000 | -201,800,000 | -97,300,000 | -125,900,000 | -42,100,000 | -115,600,000 | -61,300,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash flows from financing activities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
issuances of common stock under benefit plans | 45,600,000 | 14,400,000 | 32,100,000 | 10,000,000 | 26,400,000 | 15,800,000 | 69,900,000 | 35,400,000 | 18,800,000 | 2,900,000 | 8,200,000 | 24,600,000 | 11,400,000 | 2,600,000 | 6,100,000 | 1,800,000 | 7,500,000 | 3,000,000 | 15,200,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repurchases of common stock | 0 | -17,700,000 | -150,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payments to settle convertible senior notes | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash flows from financing activities | 45,600,000 | -3,300,000 | -117,900,000 | -290,000,000 | 26,400,000 | -293,000,000 | 69,900,000 | 35,400,000 | 18,800,000 | 2,900,000 | 8,200,000 | 24,600,000 | 11,400,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
effect of exchange rate changes on cash and cash equivalents | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
change in cash, cash equivalents and restricted cash | 76,200,000 | 69,900,000 | -38,900,000 | 209,400,000 | -256,600,000 | 145,200,000 | 133,500,000 | 56,600,000 | -159,100,000 | 48,900,000 | -106,900,000 | -66,000,000 | -56,900,000 | 15,400,000 | 165,500,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash, cash equivalents and restricted cash at beginning of period | 0 | 0 | 241,000,000 | 0 | 0 | 0 | 259,100,000 | 0 | 0 | 0 | 270,700,000 | 0 | 0 | 344,000,000 | 0 | 0 | 190,300,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash, cash equivalents and restricted cash at end of period | 76,200,000 | 69,900,000 | 202,100,000 | -116,100,000 | 209,400,000 | -256,600,000 | 404,300,000 | -42,600,000 | 133,500,000 | 56,600,000 | 111,600,000 | 48,900,000 | -106,900,000 | 278,000,000 | -56,900,000 | 15,400,000 | 355,800,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
supplemental disclosures: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued capital expenditures | -1,300,000 | -800,000 | 2,700,000 | 1,400,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
right-of-use assets acquired through operating leases | 262,600,000 | 0 | 0 | 1,800,000 | 0 | 5,600,000 | 16,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash paid for interest | 0 | 0 | 1,900,000 | 0 | 2,000,000 | 0 | 4,300,000 | 0 | 5,800,000 | 0 | 5,822,000 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash paid for income taxes | 1,100,000 | 71,900,000 | 600,000 | 73,000,000 | 51,700,000 | 92,600,000 | 200,000 | 46,500,000 | 1,600,000 | 3,200,000 | 200,000 | 10,100,000 | 1,200,000 | 1,700,000 | 1,800,000 | 14,900,000 | 0 | 82,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of (discount) premium on investments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
changes in operating assets and liabilities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
acquisition of business, net of cash acquired | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of equity investments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repurchases of common stock under accelerated buyback agreements | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payments associated with convertible senior notes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
change in cash and cash equivalents and restricted cash | 228,100,000 | 74,700,000 | -56,321,000 | 25,344,000 | 68,207,000 | -68,936,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
supplemental disclosure: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accretion of discount on investments | -7,000,000 | -7,100,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
changes in fair value of equity investments | 19,900,000 | -1,600,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of debt securities available-for-sale | -191,700,000 | -320,100,000 | -487,200,000 | -362,700,000 | -323,800,000 | -206,200,000 | -233,300,000 | -134,200,000 | -60,900,000 | -192,800,000 | -141,400,000 | -275,600,000 | -289,400,000 | -93,700,000 | -336,300,000 | -110,600,000 | -116,600,000 | -172,000,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
sales and maturities of debt securities available-for-sale | 175,100,000 | 276,300,000 | 290,800,000 | 273,000,000 | 204,700,000 | 203,900,000 | 162,200,000 | 71,200,000 | 101,100,000 | 176,500,000 | 174,000,000 | 159,700,000 | 202,900,000 | 161,300,000 | 193,100,000 | 136,200,000 | 214,700,000 | 206,500,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of equity securities | 0 | 0 | 0 | -7,700,000 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash capital expenditures | 2,200,000 | 1,100,000 | 1,600,000 | 100,000 | 200,000 | 600,000 | 0 | -200,000 | -1,900,000 | 2,800,000 | 1,600,000 | -1,900,000 | 2,100,000 | 100,000 | 300,000 | 200,000 | 100,000 | 800,000 | 898,000 | -856,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of debt discount | 4,100,000 | 4,200,000 | 4,000,000 | 3,900,000 | 4,800,000 | 5,200,000 | 5,000,000 | 5,000,000 | 4,865,000 | 4,774,000 | 4,685,000 | 4,598,000 | 4,512,000 | 4,428,000 | 4,347,000 | 4,265,000 | 4,182,000 | 4,104,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of debt issuance costs | 100,000 | 200,000 | 200,000 | 200,000 | 200,000 | 200,000 | 400,000 | 400,000 | 300,000 | 200,000 | 300,000 | 300,000 | 400,000 | 300,000 | 400,000 | 300,000 | 353,000 | 349,000 | 346,000 | 341,000 | 337,000 | 334,000 | 329,000 | 326,000 | 322,000 | 319,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
changes in fair value of equity securities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on extinguishment of convertible senior notes | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repurchases of convertible senior notes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
right-of-use assets obtained in exchange for new operating lease liabilities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
changes in fair value of equity security investments | 40,100,000 | -37,300,000 | -2,200,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
inventories | 2,900,000 | 1,600,000 | 1,800,000 | 3,900,000 | -7,700,000 | -300,000 | 1,500,000 | -5,000,000 | 2,800,000 | 1,800,000 | -2,100,000 | -7,300,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of equity security investments | 0 | 0 | -31,300,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repurchase of convertible senior notes | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
change in fair value of equity securities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents and restricted cash at beginning of period | 0 | 115,500,000 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents and restricted cash at end of period | 228,100,000 | 190,200,000 | -56,321,000 | 25,344,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
change in fair value of equity security investments | -11,100,000 | 7,400,000 | -19,900,000 | 8,200,000 | 0 | -700,000 | 7,000,000 | -11,300,000 | 16,500,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of property and equipment | -8,800,000 | -7,600,000 | -8,900,000 | -5,700,000 | -4,300,000 | -4,500,000 | -4,500,000 | -400,000 | -4,700,000 | -1,300,000 | -2,812,000 | -3,544,000 | -4,453,000 | -3,939,000 | -6,010,000 | -12,359,000 | -4,643,000 | -1,800,000 | -2,377,000 | -2,804,000 | -397,000 | -1,362,000 | -347,000 | -777,000 | -2,243,000 | -741,000 | -828,000 | -316,000 | -510,000 | -280,000 | -439,000 | -269,000 | -649,000 | -255,000 | -191,000 | -31,000 | -264,000 | -59,000 | -42,000 | -335,000 | -190,000 | -404,000 | -40,000 | -562,000 | -128,000 | -20,000 | -12,000 | -86,000 | 0 | -10,000 | -1,000 | -24,000 | -137,000 | -30,000 | -874,000 | -281,000 | -133,000 | -318,000 | -108,000 | -65,000 | -86,000 | -282,000 | -2,020,000 | -722,000 | -2,973,000 | -1,670,000 | -1,078,000 | -1,514,000 | -5,595,000 | -7,120,000 | -16,381,000 | -24,051,000 | -17,436,000 | -10,899,000 | -20,870,000 | -1,234,000 | -1,306,000 | -1,525,000 | -2,077,000 | -392,000 | |||||||||||||||
reconciliation of net income to net cash from operating activities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash from operating activities | -40,500,000 | 4,200,000 | 61,800,000 | 103,200,000 | 87,300,000 | 88,900,000 | -17,500,000 | 118,900,000 | 38,200,000 | 102,553,000 | 97,826,000 | 64,166,000 | -112,491,000 | 50,454,000 | 68,917,000 | 20,479,000 | -38,486,000 | 40,575,000 | -9,310,000 | -48,239,000 | -77,357,000 | -31,625,000 | -31,010,000 | -14,335,000 | -29,211,000 | -15,203,000 | -18,572,000 | 13,961,000 | -18,183,000 | -15,309,000 | -12,099,000 | -9,965,000 | -9,767,000 | -10,879,000 | -10,780,000 | -9,860,000 | 1,912,000 | -8,909,000 | -8,303,000 | -6,878,000 | -11,204,000 | 11,037,000 | 2,772,000 | -5,910,000 | -8,580,000 | -17,303,000 | 10,241,000 | 69,193,000 | -12,188,000 | -13,973,000 | -11,101,000 | -13,631,000 | -14,390,000 | -16,299,000 | -14,696,000 | -15,011,000 | -28,167,000 | -4,226,000 | -21,501,000 | -18,754,000 | -14,853,000 | -16,799,000 | -33,742,000 | -28,443,000 | -20,350,000 | -22,904,000 | 45,597,000 | -27,508,000 | -25,979,000 | -29,056,000 | -6,885,000 | -38,129,000 | -25,918,000 | -1,642,000 | -6,375,000 | -17,673,000 | 62,818,000 | -32,787,000 | -14,705,000 | -19,780,000 | -12,093,000 | ||||||||||||||
net cash from investing activities | -31,600,000 | 23,700,000 | -126,200,000 | -90,800,000 | 63,100,000 | -147,700,000 | 25,200,000 | 93,400,000 | 33,200,000 | -166,158,000 | -85,646,000 | -243,000 | 40,974,000 | -106,256,000 | -45,095,000 | -34,514,000 | -57,050,000 | -59,281,000 | -35,392,000 | -212,843,000 | 56,646,000 | 15,068,000 | 43,196,000 | -15,656,000 | 70,255,000 | 22,052,000 | -47,860,000 | -53,912,000 | -116,094,000 | 15,545,000 | 3,216,000 | -58,396,000 | -65,731,000 | 20,729,000 | -1,305,000 | 20,993,000 | -35,077,000 | 27,887,000 | 10,655,000 | -28,087,000 | -45,216,000 | -468,000 | 17,861,000 | 193,000 | -21,135,000 | -6,075,000 | -28,053,000 | -26,300,000 | 5,724,000 | 6,086,000 | 7,802,000 | 581,000 | -2,412,000 | 4,916,000 | 3,229,000 | -320,000 | 36,603,000 | -6,578,000 | 21,439,000 | -7,519,000 | 13,494,000 | 23,165,000 | 24,749,000 | 12,927,000 | 59,440,000 | -9,802,000 | -22,716,000 | 31,456,000 | 10,444,000 | 6,129,000 | 57,674,000 | 9,067,000 | -54,401,000 | -31,112,000 | -93,812,000 | -18,588,000 | -43,134,000 | 17,719,000 | 21,719,000 | 14,995,000 | -100,454,000 | ||||||||||||||
partial repurchase of convertible senior notes | 0 | 0 | 0 | -100,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash from financing activities | 6,100,000 | 1,800,000 | 7,500,000 | 3,000,000 | 15,100,000 | -179,400,000 | 2,500,000 | 15,800,000 | 3,300,000 | 7,284,000 | 13,164,000 | 4,284,000 | 2,581,000 | 1,782,000 | 5,490,000 | 6,123,000 | 16,135,000 | 5,600,000 | 3,022,000 | 506,493,000 | 1,531,000 | 63,000 | 1,329,000 | 936,000 | 62,000 | 968,000 | 740,000 | 1,759,000 | 273,525,000 | 1,732,000 | 484,000 | 274,000 | 136,241,000 | 50,000 | 2,661,000 | 1,625,000 | 966,000 | 288,000 | 118,000 | 43,000 | 83,253,000 | 22,000 | 45,000 | 162,000 | 57,000 | 99,000 | 22,000 | 3,000 | 21,359,000 | -275,000 | -325,000 | -391,000 | -461,000 | 60,118,000 | -1,073,000 | -699,000 | -1,165,000 | -1,145,000 | -1,415,000 | 190,000 | 12,456,000 | 7,270,000 | 4,004,000 | -19,000 | -922,000 | -740,000 | 11,170,000 | 13,788,000 | 12,474,000 | 14,788,000 | 189,111,000 | 2,746,000 | 4,414,000 | 2,755,000 | 1,756,000 | 1,327,000 | -27,000 | ||||||||||||||||||
share-based compensation expense | 35,600,000 | 37,100,000 | 28,600,000 | 32,900,000 | 21,000,000 | 26,700,000 | 29,500,000 | 22,800,000 | 21,317,000 | 20,250,000 | 17,931,000 | 15,764,000 | 875,000 | 843,000 | 559,000 | 1,699,000 | 1,041,000 | 1,870,000 | 1,751,000 | 2,247,000 | 2,189,000 | 2,554,000 | 2,794,000 | 2,409,000 | 3,188,000 | 2,690,000 | 6,788,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
issuance of common stock | 2,500,000 | 15,800,000 | 3,300,000 | 7,284,000 | 13,164,000 | 4,284,000 | 2,581,000 | 1,782,000 | 5,490,000 | 6,123,000 | 16,135,000 | 5,600,000 | 3,022,000 | 3,712,000 | 1,531,000 | 63,000 | 1,329,000 | 936,000 | 62,000 | 968,000 | 740,000 | 1,759,000 | 273,525,000 | 1,732,000 | 484,000 | 274,000 | 136,241,000 | 50,000 | 2,661,000 | 1,625,000 | 966,000 | 288,000 | 118,000 | 43,000 | 83,253,000 | 22,000 | 45,000 | 162,000 | 57,000 | 99,000 | 22,000 | 3,000 | 21,359,000 | 1,000 | 0 | 16,000 | 2,000 | 500,000 | 73,000 | 206,000 | 44,000 | 1,689,000 | 13,910,000 | 8,774,000 | 5,645,000 | 1,755,000 | 796,000 | 1,596,000 | 1,352,000 | 2,038,000 | 1,777,000 | 882,000 | 189,051,000 | 2,633,000 | 4,047,000 | 1,509,000 | 554,000 | 851,000 | 545,000 | ||||||||||||||||||||||||||
other current assets and liabilities | -4,100,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
blank | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net (accretion of discounts) amortization of premiums on investments | -499,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
change in fair value of restricted equity securities | 7,182,000 | 28,450,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other changes in operating assets and liabilities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of marketable securities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
sales and maturities of marketable securities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchase of restricted equity securities | -14,135,000 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sales of property and equipment | 0 | 4,000 | 0 | 4,000 | 4,000 | 0 | 12,000 | 18,000 | 0 | 0 | 0 | 10,000 | 3,000 | 0 | 0 | 0 | 9,000 | 0 | 0 | 5,000 | 40,000 | 2,000 | 13,000 | 7,000 | 0 | 0 | 25,000 | 58,000 | 86,000 | 18,000 | 83,000 | 94,000 | 35,000 | 61,000 | 146,000 | 239,000 | 609,000 | 33,000 | 312,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of convertible senior notes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
depreciation and amortization | 2,009,000 | 1,786,000 | 1,566,000 | 1,275,000 | 1,080,000 | 883,000 | 786,000 | 706,000 | 616,000 | 589,000 | 489,000 | 445,000 | 408,000 | 324,000 | 276,000 | 270,000 | 244,000 | 251,000 | 244,000 | 224,000 | 217,000 | 208,000 | 178,000 | 156,000 | 168,000 | 172,000 | 175,000 | 176,000 | 163,000 | 166,000 | 152,000 | 142,000 | 138,000 | 174,000 | 240,000 | 304,000 | 344,000 | 360,000 | 428,000 | 570,000 | 759,000 | 881,000 | 969,000 | 1,573,000 | 1,970,000 | 2,000,000 | 2,067,000 | 2,166,000 | 2,211,000 | 2,466,000 | 2,561,000 | 2,579,000 | 2,631,000 | 2,690,000 | 2,666,000 | 2,278,000 | 2,092,000 | 1,468,000 | 1,243,000 | ||||||||||||||||||||||||||||||||||||
other current assets | -2,198,000 | 2,128,000 | -2,110,000 | -3,943,000 | -2,144,000 | -750,000 | 568,000 | -1,878,000 | -281,000 | -1,244,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other liabilities | 3,331,000 | 5,947,000 | 5,363,000 | -28,000 | 0 | 1,000 | 27,000 | -1,000 | 1,000 | 101,000 | 0 | -1,481,000 | 45,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net loss | 51,338,000 | -102,115,000 | -5,913,000 | -41,818,000 | 6,894,000 | -11,125,000 | -59,985,000 | -78,326,000 | -44,659,000 | -36,887,000 | -40,280,000 | -19,264,000 | -29,315,000 | -34,435,000 | -23,987,000 | -1,192,000 | -15,875,000 | -13,381,000 | -11,842,000 | -11,131,000 | -12,242,000 | -12,075,000 | -26,364,000 | -25,720,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
reconciliation of net loss to net cash from operating activities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of discounts/premiums on investments | -542,000 | -290,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
change in fair value of investment in restricted equity securities | -1,680,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of investments | -116,307,000 | -216,673,000 | -105,213,000 | -84,722,000 | -139,354,000 | -138,870,000 | -79,506,000 | -307,155,000 | -57,877,000 | -81,635,000 | -47,653,000 | -113,927,000 | -55,561,000 | -72,615,000 | -89,577,000 | -127,639,000 | -159,221,000 | -16,388,000 | -32,819,000 | -99,430,000 | -108,907,000 | -14,949,000 | -34,767,000 | -29,111,000 | -66,501,000 | -26,808,000 | -16,344,000 | -47,776,000 | -75,385,000 | -34,913,000 | -28,307,000 | -25,230,000 | -50,649,000 | -31,195,000 | -31,870,000 | -735,000 | -719,000 | -2,401,000 | -12,945,000 | -17,884,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
sales and maturities of investments | 215,936,000 | 116,423,000 | 72,477,000 | 54,839,000 | 84,086,000 | 46,911,000 | 94,239,000 | 116,085,000 | 91,626,000 | 100,396,000 | 126,754,000 | 42,009,000 | 74,221,000 | 43,398,000 | 36,304,000 | 41,678,000 | 43,391,000 | 33,487,000 | 50,349,000 | 31,470,000 | 27,334,000 | 19,907,000 | 30,548,000 | 46,668,000 | 25,533,000 | 29,453,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
investment in equity securities | -54,720,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents and restricted cash at beginning of the period | 147,191,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents and restricted cash at end of the period | 78,255,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of premiums on investments | 13,000 | 372,000 | 552,000 | 512,000 | 554,000 | 606,000 | 327,000 | 269,000 | 369,000 | 711,000 | 1,043,000 | 1,397,000 | 1,721,000 | 1,732,000 | 1,568,000 | 1,011,000 | 1,047,000 | 1,151,000 | 977,000 | 617,000 | 735,000 | 750,000 | 719,000 | 639,000 | 655,000 | 990,000 | 867,000 | 623,000 | 569,000 | 619,000 | 652,000 | 501,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred rent | -44,000 | -28,000 | -28,000 | 1,470,000 | -125,000 | -114,000 | -86,000 | -72,000 | -72,000 | -64,000 | -41,000 | -28,000 | 80,000 | -27,000 | -5,000 | 7,000 | 6,000 | 6,000 | 27,000 | 39,000 | 38,000 | 38,000 | 67,000 | 79,000 | 79,000 | 80,000 | 102,000 | 117,000 | 116,000 | 99,000 | 161,000 | 173,000 | 173,000 | 173,000 | 200,000 | -50,000 | 323,000 | 323,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sales of assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cease-use expense | 0 | 0 | 0 | 0 | 0 | -584,000 | 957,000 | -7,000 | -87,000 | 76,000 | 100,000 | 2,398,000 | 120,000 | 134,000 | 147,000 | 126,000 | 89,000 | 941,000 | 4,828,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
reimbursements for tenant improvements | 5,044,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of senior convertible notes | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net change in cash, cash equivalents, and restricted cash | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash, cash equivalents, and restricted cash at beginning of the period | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash, cash equivalents, and restricted cash at end of the period | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
supplemental disclosures | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash share-based compensation expense | 13,070,000 | 11,851,000 | 19,879,000 | 13,452,000 | 10,204,000 | 9,890,000 | 8,976,000 | 7,953,000 | 6,319,000 | 7,274,000 | 6,918,000 | 6,226,000 | 13,903,000 | 4,663,000 | 3,600,000 | 2,444,000 | 2,664,000 | 2,827,000 | 2,447,000 | 1,696,000 | 1,711,000 | 1,680,000 | 1,732,000 | 1,310,000 | 1,370,000 | 1,373,000 | 1,426,000 | 907,000 | 904,000 | 395,000 | 712,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other current liabilities | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net increase in cash, cash equivalents and restricted cash | 29,312,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash, cash equivalents and restricted cash at beginning of the period | 0 | 0 | 259,212,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash, cash equivalents and restricted cash at end of the period | 29,312,000 | -7,912,000 | 179,811,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
adjustments to reconcile net loss to net cash from operating activities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale of assets | -147,000 | -201,000 | -156,000 | -188,000 | -881,000 | -879,000 | -863,000 | -844,000 | -868,000 | -856,000 | -838,000 | -828,000 | -829,000 | -839,000 | -812,000 | -806,000 | -810,000 | -794,000 | -788,000 | -787,000 | -800,000 | -795,000 | -773,000 | -759,000 | -759,000 | -783,000 | -3,011,000 | -86,000 | 718,000 | -816,000 | -2,958,000 | -35,000 | -53,000 | -115,000 | -2,894,000 | -570,000 | -21,000 | -141,000 | -164,000 | -34,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
cease-use liability | -62,000 | -59,000 | -60,000 | -62,000 | -66,000 | -61,000 | -58,000 | -71,000 | -110,000 | -83,000 | -175,000 | -239,000 | -113,000 | -110,000 | -104,000 | -102,000 | -102,000 | -102,000 | -97,000 | -197,000 | -194,000 | -70,000 | -64,000 | -65,000 | -64,000 | -4,340,000 | -729,000 | -1,219,000 | -1,214,000 | -1,140,000 | -1,129,000 | -1,123,000 | -1,145,000 | -5,872,000 | -977,000 | -995,000 | -2,007,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net decrease in cash, cash equivalents and restricted cash | -79,401,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash flow from operating activities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenues | 0 | 0 | 0 | 10,231,000 | -730,000 | -729,000 | -730,000 | -730,000 | -7,986,000 | -7,990,000 | -9,029,000 | -9,237,000 | -9,239,000 | -9,238,000 | -9,244,000 | -9,306,000 | 75,828,000 | -9,228,000 | -3,364,000 | -746,000 | -717,000 | -722,000 | -731,000 | -744,000 | -719,000 | -723,000 | -730,000 | -739,000 | 17,487,000 | 27,000 | -27,000 | 36,000 | -976,000 | -477,000 | -726,000 | -4,358,000 | -6,359,000 | -5,448,000 | -5,647,000 | -5,683,000 | -8,113,000 | -7,163,000 | -10,262,000 | -12,695,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||
cash flow from investing activities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
sales/maturities of investments | 24,807,000 | 3,872,000 | 580,000 | 5,580,000 | 6,585,000 | 7,830,000 | 2,960,000 | 10,240,000 | 20,945,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deposits and restricted cash | 113,000 | 0 | 470,000 | -200,000 | 0 | 0 | 108,000 | -200,000 | 0 | 24,000 | -1,000 | 0 | 1,822,000 | -24,000 | 0 | -2,000 | 231,000 | -4,000 | -2,000 | -2,000 | -3,000 | 92,000 | -10,000 | 5,000 | 6,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash flow from financing activities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net change in cash and cash equivalents | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents at beginning of the year | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents at end of the year | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest paid | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
taxes paid | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other non-current liabilities | 0 | -25,000 | 152,000 | -1,489,000 | -299,000 | -827,000 | -494,000 | -181,000 | -74,000 | -393,000 | 97,000 | 382,000 | -30,000 | 54,000 | 258,000 | -1,641,000 | 1,286,000 | 487,000 | 450,000 | 283,000 | 163,000 | 356,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net increase in cash and cash equivalents | -41,680,000 | 245,411,000 | -19,180,000 | 13,515,000 | -29,055,000 | 41,106,000 | -65,692,000 | -38,192,000 | 139,248,000 | 60,743,000 | -32,199,000 | 26,833,000 | 10,591,000 | 20,678,000 | -5,555,000 | -29,658,000 | -23,279,000 | -17,790,000 | 42,896,000 | 14,895,000 | -16,802,000 | 7,975,000 | 49,314,000 | -1,135,000 | -26,972,000 | -2,524,000 | 5,221,000 | -10,408,000 | -15,326,000 | 51,546,000 | -25,436,000 | -23,667,000 | -67,845,000 | -17,966,000 | 24,098,000 | -3,458,000 | -112,574,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents at beginning of the period | 0 | 0 | 83,267,000 | 0 | 0 | 74,195,000 | 0 | 0 | 31,014,000 | 0 | 0 | 44,789,000 | 0 | 0 | 63,754,000 | 0 | 0 | 50,107,000 | 0 | 0 | 54,051,000 | 0 | 0 | 37,329,000 | 0 | 0 | 68,467,000 | 0 | 0 | 99,664,000 | 0 | 0 | 80,981,000 | 0 | 0 | 49,948,000 | 0 | 0 | 61,027,000 | 0 | 0 | 105,854,000 | 0 | 0 | 44,313,000 | 0 | 0 | 163,888,000 | |||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents at end of the period | -41,680,000 | 245,411,000 | 64,087,000 | 13,515,000 | -29,055,000 | 115,301,000 | -65,692,000 | -38,192,000 | 170,262,000 | -8,399,000 | -68,087,000 | 105,532,000 | -9,424,000 | 12,758,000 | 31,555,000 | 2,470,000 | -34,922,000 | 76,940,000 | 20,678,000 | -5,555,000 | 24,393,000 | -17,790,000 | 42,896,000 | 52,224,000 | -3,299,000 | -13,050,000 | 51,665,000 | -11,792,000 | -15,722,000 | 107,639,000 | -1,135,000 | -26,972,000 | 78,457,000 | -10,408,000 | -15,326,000 | 101,494,000 | 26,885,000 | 3,929,000 | 44,570,000 | 61,959,000 | -15,274,000 | 38,009,000 | 88,924,000 | -33,515,000 | 68,411,000 | 8,770,000 | -3,458,000 | 51,314,000 | |||||||||||||||||||||||||||||||||||||||||||||||
supplemental cash flow information | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash paid for interest during the period | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts receivable under collaboration agreements and other assets | -779,000 | -14,577,000 | -30,552,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts receivable and other assets | -515,000 | 21,122,000 | -19,617,000 | 67,000 | 1,241,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
receivables under collaboration agreements and other assets | -1,275,000 | -1,046,000 | 850,000 | -150,000 | 4,000 | 14,090,000 | -339,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net decrease in cash and cash equivalents | -8,399,000 | -9,424,000 | 2,470,000 | -3,299,000 | -11,792,000 | 3,929,000 | -16,457,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on sale of investments | 0 | 0 | 320,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
realized gain on sale of auction rate securities | -694,000 | -35,000 | -36,000 | -555,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fair value adjustment for auction rate security rights | 150,000 | 258,000 | 196,000 | 211,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fair value adjustment of auction rate securities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other-than-temporary impairment for auction rate securities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest paid on debt obligations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
realized loss on sale of investments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred gain on sale of real estate | -736,000 | -716,000 | -714,000 | -715,000 | -695,000 | -694,000 | -695,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
principal payments on debt | -276,000 | -325,000 | -424,000 | -461,000 | -48,643,000 | -1,075,000 | -1,351,000 | -1,459,000 | -1,499,000 | -1,454,000 | -61,656,000 | -1,186,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
supplemental disclosures of cash flow information: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fair value adjustment for trading auction rate security rights | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fair value adjustment trading for auction rate securities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of premiums on short term-investments | 253,000 | -10,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of trading securities | 9,100,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts receivable and other current assets | -4,248,000 | -298,000 | -167,000 | -55,000 | -188,000 | 121,000 | 911,000 | -133,000 | 730,000 | 1,105,000 | -216,000 | -49,000 | 224,000 | 7,532,000 | -6,052,000 | 1,306,000 | 3,925,000 | -3,991,000 | 548,000 | 21,467,000 | -18,130,000 | 2,559,000 | -375,000 | -2,194,000 | -200,000 | 8,724,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
upfront licensing fees | 10,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fair value adjustment for auction rate securities | -330,000 | -425,000 | 1,237,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss/(gain) on sale of investments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
asset impairment | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loan forgiveness on notes receivable | 69,000 | 0 | 70,000 | 78,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash stock compensation expense | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
leaseback financing obligation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of premiums/discounts on short term-investments | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other non-current assets | -6,000 | 1,810,000 | 189,000 | -172,000 | 14,000 | 112,000 | -139,000 | -22,000 | -606,000 | 18,000 | 76,000 | 413,000 | -176,000 | -184,000 | -529,000 | -199,000 | -49,000 | -53,000 | -335,000 | 287,000 | 300,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale of investments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(gain)/loss on sale/abandonment of assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(gain)/loss on sale of investments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of short-term investments | -9,984,000 | -44,172,000 | -1,819,000 | -9,651,000 | -38,996,000 | -1,523,000 | 317,000 | -1,817,000 | -61,021,000 | -333,307,000 | -29,552,000 | 580,000 | -20,550,000 | -7,210,000 | -64,706,000 | -182,368,000 | -289,438,000 | -85,855,000 | -148,688,000 | -101,071,000 | -112,680,000 | -69,731,000 | -100,449,000 | -49,843,000 | -181,566,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
sales/maturities of short-term investments | 46,688,000 | 38,885,000 | 23,450,000 | 2,240,000 | 52,555,000 | 24,249,000 | 24,714,000 | 16,764,000 | 121,183,000 | 326,478,000 | 8,506,000 | 31,954,000 | 33,033,000 | 5,940,000 | 130,050,000 | 207,959,000 | 301,100,000 | 57,582,000 | 65,775,000 | 103,853,000 | 73,280,000 | 88,756,000 | 123,693,000 | 66,915,000 | 81,504,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale and disposal of assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
realized loss on auction rate securities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restricted cash | 127,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
sale of property and equipment | 71,000 | 276,000 | 174,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash compensation expense | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payments received on notes receivable from employees | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(gain)/loss on disposal of fixed assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loan forgiveness on notes receivable from stockholder | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from the sale of property and equipment | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
sales force allowance prepayment | 8,240,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
principal payments on long-term obligations | -1,238,000 | -1,718,000 | -1,004,000 | -14,840,000 | -721,000 | -646,000 | -573,000 | -592,000 | -576,000 | -572,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on sale/abandonment of assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred expenses | 997,000 | -137,000 | -24,000 | 164,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchase of prepaid royalty stream | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds received from debt | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
tax benefit from exercise of stock options | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stock issued for prepaid royalty | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on disposal of fixed assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
operating activities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
investing activities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
financing activities | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of property and building | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-cash compensation expenses | 107,000 | 105,000 | 209,000 | 134,000 | 148,000 | 132,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchase of royalty stream | 0 | 0 | -50,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deposit and restricted cash | 0 | 0 | -525,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from debt financing | 11,701,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
principal payments on long-term debt | -1,641,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
supplemental information: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
increase in stockholder’s equity and prepaid royalties from issuance of common stock | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
as reported | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stock option expense | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
pro forma net income | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payments received on notes receivable from stockholders | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restricted cash and other non-current assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deposits | -550,000 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds received from issuance of debt | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
increase in property and related debt resulting from increasing ownership percentage in science park center llc | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss per share as reported | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
pro forma loss per share | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deposit | 7,988,000 | -2,500,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(gain) loss on sale/abandonment of assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of long-term debt | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from capital lease financing | 834,000 | 1,013,000 | 1,690,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
increase in property and related debt resulting form increasing ownership percentage in science park center llc | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
adjustments to reconcile net income to net cash | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
used in operating activities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on abandonment of assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loan forgiveness on notes receivable from stockholders | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds received from long-term obligations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
adjustments to reconcile net loss to net cash |