7Baggers
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 2004-03-31 2003-12-31 2003-09-30 2003-06-30 2003-03-31 2002-12-31 2002-09-30 2002-06-30 2002-03-31 
      
    		                                                                                              
      cash flows from operating activities:
    		                                                                                              
      net income
    		209,500,000 107,500,000 7,900,000 129,800,000 65,000,000 43,400,000 147,700,000 83,100,000 95,500,000 -76,600,000 89,000,000 68,500,000 -16,900,000 13,900,000 -7,300,000 22,500,000 42,300,000 32,100,000 347,900,000 -57,600,000 79,600,000 37,400,000 34,000,000 53,789,000 51,338,000 -102,115,000 18,078,000 50,764,000 -5,913,000 -41,818,000 6,894,000 -11,125,000 -59,985,000 -78,326,000 -44,659,000 -36,887,000 -40,280,000 -19,264,000 -29,315,000 -34,435,000 -23,987,000 -1,192,000 -19,444,000 -15,875,000 -13,381,000 -11,842,000 -10,642,000 -11,131,000 -12,242,000 -12,075,000 9,490,000 -3,078,000 -501,000 -886,000 1,331,000 31,382,000 1,976,000 2,882,000 2,487,000 3,333,000 -5,152,000 -8,636,000 -7,916,000 -8,177,000 -15,280,000 -19,665,000 -28,854,000 -17,711,000 -20,971,000 -21,077,000 -127,975,000 -27,240,000 -26,364,000 -25,720,000 -14,712,000 -39,143,000 -27,449,000 -25,901,000 -23,908,000 26,151,000 -5,604,000 -18,830,000 -20,615,000 -1,647,000 -11,131,000 -12,380,000 3,193,000 -9,834,000 -10,225,000 -13,390,000 -38,787,000 -20,234,000 -19,751,000 -15,764,000 
      adjustments to reconcile net income to net cash from operating activities:
    		                                                                                              
      stock-based compensation expense
    		53,700,000 52,800,000 52,800,000 41,500,000 43,100,000 44,500,000 38,100,000 47,800,000 68,500,000 39,900,000 43,500,000 43,100,000 49,500,000 37,000,000                                                                                 
      charges associated with convertible senior notes
    		   0 49,700,000 88,700,000                                                                                         
      impairment charges associated with leased properties
    		0   0                                                                                           
      depreciation
    		6,700,000 6,300,000 6,600,000 5,600,000 6,400,000 5,300,000 4,900,000 4,600,000 4,200,000 4,100,000 3,900,000 4,000,000 3,900,000 3,300,000 3,000,000 2,800,000 2,600,000 2,500,000 2,200,000 2,200,000 2,100,000 2,100,000                                                          2,544,000 2,505,000 2,442,000             
      accretion of discount on available-for-sale debt securities
    		-2,700,000 -3,400,000 -4,600,000                                                                                            
      amortization of intangible assets
    		1,000,000 1,000,000 1,000,000 900,000 900,000 900,000 800,000 900,000 900,000 900,000                                                                                     
      changes in fair values of equity investments
    		-30,600,000 6,700,000 30,600,000                                                                                            
      deferred income taxes
    		168,300,000 -37,400,000 -13,700,000 -34,900,000 -41,300,000 -15,600,000 20,600,000 -4,200,000 -41,500,000 -31,600,000 13,500,000 9,000,000 -3,100,000 -300,000 -4,700,000 5,700,000 9,500,000 -6,200,000                                                                             
      non-cash lease expense
    		6,600,000                                                                                              
      other
    		200,000 -7,400,000 7,900,000 300,000 200,000 3,400,000 12,300,000 -6,500,000 -4,300,000 -2,400,000 1,100,000 700,000 1,500,000 800,000 -3,300,000 2,100,000 3,000,000 2,600,000 2,000,000 1,000,000 300,000 400,000 -38,000 676,000 0 116,000                                                                     
      change in operating assets and liabilities:
    		                                                                                              
      accounts receivable
    		-132,300,000 -79,700,000 -36,900,000 -12,900,000 -17,600,000 -11,300,000 -21,400,000 -30,400,000 4,200,000 -41,700,000 -46,500,000 -22,200,000 -15,500,000 -78,000,000 -21,700,000 -5,300,000 -10,700,000 9,300,000 -200,000 -8,500,000 300,000 -22,100,000 -11,257,000 -18,795,000 -23,393,000 -15,724,000 -2,143,000 -11,451,000 1,978,000 -13,497,000 -1,309,000 -23,744,000                                                               
      inventory
    		-12,300,000 2,100,000 -1,700,000 -3,300,000 -5,300,000 1,100,000               -800,000 -3,900,000 -6,490,000 1,220,000 599,000 -1,753,000 383,000 -636,000   -782,000 -114,000                                                               
      accounts payable and accrued liabilities
    		55,800,000 15,500,000 12,400,000 39,400,000 -59,500,000 -18,600,000 -83,000,000 124,400,000 16,200,000 6,700,000 37,600,000 32,800,000 32,700,000 11,500,000 19,100,000 8,700,000 18,000,000 11,000,000 -1,200,000 33,200,000 11,100,000 -16,200,000 41,611,000 4,605,000 24,306,000 -16,567,000 8,646,000 11,304,000 12,143,000 -7,870,000 16,231,000 10,480,000 7,554,000 -6,927,000 3,520,000 -306,000 3,531,000 -2,347,000 5,884,000 2,284,000 2,219,000 -546,000 1,547,000 1,922,000 1,356,000 -1,127,000 -923,000 -554,000 1,496,000 -968,000 -541,000 1,189,000 794,000 -1,999,000 1,234,000 82,000 1,852,000 -3,019,000 167,000 1,434,000 845,000 -1,461,000 -943,000 -2,485,000 249,000 -897,000 -3,269,000 -201,000 1,946,000 -11,465,000 8,199,000 1,631,000 1,753,000 -1,717,000 199,000 -1,805,000 442,000 -4,551,000 3,251,000 375,000 -1,017,000 -6,504,000 -4,336,000 3,060,000 -18,467,000 -11,406,000         
      income tax assets and liabilities
    		                                                                                              
      other assets and liabilities
    		-42,100,000 23,000,000 2,500,000 -18,800,000 -3,900,000 -2,800,000 51,600,000 -50,900,000 71,400,000 -24,300,000 3,500,000 -18,500,000 8,500,000 -10,700,000 12,500,000 -27,200,000 3,800,000 1,700,000 6,100,000 -28,300,000                                                                           
      cash flows from operating activities
    		227,500,000 102,000,000 64,800,000 158,000,000 64,600,000 130,300,000 123,500,000 212,000,000 179,600,000 -125,200,000 143,000,000 98,800,000                                                                                   
      cash flows from investing activities:
    		                                                                                              
      purchases of available-for-sale debt securities
    		-408,500,000 -315,100,000 -273,200,000                     -231,189,000                                                                       
      sales and maturities of available-for-sale debt securities
    		225,000,000 298,600,000 298,100,000                     149,083,000                                                                       
      capital expenditures
    		-13,200,000 -12,500,000 -10,700,000 -8,100,000 -11,600,000 -11,200,000 -5,400,000 -7,600,000 -6,800,000 -8,500,000 -1,800,000                                                                                    
      free cash flows
    		                                                                                              
      cash flows from investing activities
    		-196,700,000 -29,000,000 14,200,000 24,700,000 -28,200,000 -55,000,000 -201,800,000 -97,300,000 -125,900,000 -42,100,000 -115,600,000 -61,300,000                                                                                   
      cash flows from financing activities:
    		                                                                                              
      issuances of common stock under benefit plans
    		45,600,000 14,400,000 32,100,000 26,400,000 15,800,000 69,900,000 35,400,000 18,800,000 2,900,000 8,200,000 24,600,000 11,400,000 2,600,000 6,100,000 1,800,000 7,500,000 3,000,000 15,200,000                                                                             
      repurchases of common stock
    		0 -17,700,000 -150,000,000                                                                                            
      payments to settle convertible senior notes
    		   0                                                                                           
      cash flows from financing activities
    		45,600,000 -3,300,000 -117,900,000 26,400,000 -293,000,000 69,900,000 35,400,000 18,800,000 2,900,000 8,200,000 24,600,000 11,400,000                                                                                   
      effect of exchange rate changes on cash and cash equivalents
    		                                                                                              
      change in cash, cash equivalents and restricted cash
    		76,200,000 69,900,000 -38,900,000 209,400,000 -256,600,000 145,200,000  133,500,000 56,600,000 -159,100,000  48,900,000 -106,900,000 -66,000,000  -56,900,000 15,400,000 165,500,000                                                                             
      cash, cash equivalents and restricted cash at beginning of period
    		0 0 241,000,000 0 0 259,100,000 0 0 0 270,700,000  0 0 344,000,000  0 0 190,300,000                                                                             
      cash, cash equivalents and restricted cash at end of period
    		76,200,000 69,900,000 202,100,000 209,400,000 -256,600,000 404,300,000 -42,600,000 133,500,000 56,600,000 111,600,000  48,900,000 -106,900,000 278,000,000  -56,900,000 15,400,000 355,800,000                                                                             
      supplemental disclosures:
    		                                                                                              
      accrued capital expenditures
    		-1,300,000 -800,000 2,700,000                                                                                            
      right-of-use assets acquired through operating leases
    		   0    0       1,800,000 0 5,600,000 16,000,000                                                                             
      cash paid for interest
    		   0   1,900,000 0   2,000,000 0   4,300,000 0   5,800,000 0   5,822,000 0                                                                       
      cash paid for income taxes
    		1,100,000 71,900,000 600,000 51,700,000 92,600,000 200,000 46,500,000 1,600,000 3,200,000 200,000 10,100,000 1,200,000   1,700,000 1,800,000   14,900,000    0 82,000                                                                       
      purchases of equity investments
    		                                                                                              
      accretion of discount on investments
    		    -7,000,000 -7,100,000                                                                                         
      changes in fair value of equity investments
    		    19,900,000 -1,600,000                                                                                         
      purchases of debt securities available-for-sale
    		    -191,700,000 -320,100,000 -487,200,000 -362,700,000 -323,800,000 -206,200,000 -233,300,000 -134,200,000 -60,900,000 -192,800,000 -141,400,000 -275,600,000 -289,400,000 -93,700,000 -336,300,000 -110,600,000 -116,600,000 -172,000,000                                                                         
      sales and maturities of debt securities available-for-sale
    		    175,100,000 276,300,000 290,800,000 273,000,000 204,700,000 203,900,000 162,200,000 71,200,000 101,100,000 176,500,000 174,000,000 159,700,000 202,900,000 161,300,000 193,100,000 136,200,000 214,700,000 206,500,000                                                                         
      purchases of equity securities
    		          0 0 0 -7,700,000 0                                                                                
      non-cash capital expenditures
    		    2,200,000 1,100,000 1,600,000 100,000 200,000 600,000 0 -200,000 -1,900,000 2,800,000 1,600,000 -1,900,000 2,100,000 100,000 300,000 200,000 100,000 800,000 898,000 -856,000                                                                       
      amortization of (discount) premium on investments
    		                                                                                              
      amortization of debt discount
    		              4,100,000 4,200,000 4,000,000 3,900,000 4,800,000 5,200,000 5,000,000 5,000,000 4,865,000 4,774,000 4,685,000 4,598,000 4,512,000 4,428,000 4,347,000 4,265,000 4,182,000 4,104,000                                                               
      amortization of debt issuance costs
    		      100,000 200,000 200,000 200,000 200,000 200,000 400,000 400,000 300,000 200,000 300,000 300,000 400,000 300,000 400,000 300,000 353,000 349,000 346,000 341,000 337,000 334,000 329,000 326,000 322,000 319,000                                                               
      changes in fair value of equity securities
    		                                                                                              
      loss on extinguishment of convertible senior notes
    		          0 0                                                                                   
      changes in operating assets and liabilities:
    		                                                                                              
      acquisition of business, net of cash acquired
    		                                                                                              
      repurchases of convertible senior notes
    		                                                                                              
      change in cash and cash equivalents and restricted cash
    		                    228,100,000 74,700,000 -56,321,000 25,344,000 68,207,000 -68,936,000                                                                     
      supplemental disclosure:
    		                                                                                              
      right-of-use assets obtained in exchange for new operating lease liabilities
    		                                                                                              
      changes in fair value of equity security investments
    		       40,100,000 -37,300,000 -2,200,000                                                                                     
      inventories
    		       2,900,000 1,600,000 1,800,000 3,900,000 -7,700,000 -300,000 1,500,000 -5,000,000 2,800,000 1,800,000 -2,100,000 -7,300,000                                                                            
      purchases of equity security investments
    		       0 0 -31,300,000                                                                                     
      repurchase of convertible senior notes
    		           0                                                                                   
      change in fair value of equity securities
    		                                                                                              
      cash and cash equivalents and restricted cash at beginning of period
    		                    0 115,500,000 0 0                                                                       
      cash and cash equivalents and restricted cash at end of period
    		                    228,100,000 190,200,000 -56,321,000 25,344,000                                                                       
      change in fair value of equity security investments
    		           -11,100,000 7,400,000 -19,900,000  8,200,000 0 -700,000  7,000,000 -11,300,000 16,500,000                                                                         
      purchases of property and equipment
    		            -8,800,000 -7,600,000 -8,900,000 -5,700,000 -4,300,000 -4,500,000 -4,500,000 -400,000 -4,700,000 -1,300,000 -2,812,000 -3,544,000 -4,453,000 -3,939,000 -6,010,000 -12,359,000 -4,643,000 -1,800,000 -2,377,000 -2,804,000 -397,000 -1,362,000 -347,000 -777,000 -2,243,000 -741,000 -828,000 -316,000 -510,000 -280,000 -439,000 -269,000 -649,000 -255,000 -191,000 -31,000 -264,000 -59,000 -42,000 -335,000 -190,000 -404,000 -40,000 -562,000 -128,000 -20,000 -12,000 -86,000   0 -10,000 -1,000 -24,000 -137,000 -30,000 -874,000 -281,000 -133,000 -318,000 -108,000 -65,000 -86,000 -282,000 -2,020,000 -722,000 -2,973,000 -1,670,000 -1,078,000 -1,514,000 -5,595,000 -7,120,000 -16,381,000 -24,051,000 -17,436,000 -10,899,000 -20,870,000 -1,234,000 -1,306,000 -1,525,000 -2,077,000 -392,000 
      reconciliation of net income to net cash from operating activities:
    		                                                                                              
      net cash from operating activities
    		             -40,500,000 4,200,000 61,800,000 103,200,000 87,300,000 88,900,000 -17,500,000 118,900,000 38,200,000 102,553,000 97,826,000 64,166,000 -112,491,000 50,454,000 68,917,000 20,479,000 -38,486,000 40,575,000 -9,310,000 -48,239,000 -77,357,000 -31,625,000 -31,010,000 -14,335,000 -29,211,000 -15,203,000 -18,572,000 13,961,000 -18,183,000 -15,309,000 -12,099,000 -9,965,000 -9,767,000 -10,879,000 -10,780,000 -9,860,000 1,912,000 -8,909,000 -8,303,000 -6,878,000 -11,204,000 11,037,000 2,772,000 -5,910,000 -8,580,000 -17,303,000 10,241,000 69,193,000 -12,188,000 -13,973,000 -11,101,000 -13,631,000 -14,390,000 -16,299,000 -14,696,000 -15,011,000 -28,167,000 -4,226,000 -21,501,000 -18,754,000 -14,853,000 -16,799,000 -33,742,000 -28,443,000 -20,350,000 -22,904,000 45,597,000 -27,508,000 -25,979,000 -29,056,000 -6,885,000 -38,129,000 -25,918,000 -1,642,000 -6,375,000 -17,673,000 62,818,000 -32,787,000 -14,705,000 -19,780,000 -12,093,000 
      net cash from investing activities
    		             -31,600,000 23,700,000 -126,200,000 -90,800,000 63,100,000 -147,700,000 25,200,000 93,400,000 33,200,000 -166,158,000 -85,646,000 -243,000 40,974,000 -106,256,000 -45,095,000 -34,514,000 -57,050,000 -59,281,000 -35,392,000 -212,843,000 56,646,000 15,068,000 43,196,000   22,052,000 -47,860,000 -53,912,000 -116,094,000 15,545,000 3,216,000 -58,396,000 -65,731,000 20,729,000 -1,305,000 20,993,000 -35,077,000 27,887,000 10,655,000 -28,087,000 -45,216,000 -468,000 17,861,000 193,000 -21,135,000 -6,075,000 -28,053,000 -26,300,000 5,724,000 6,086,000 7,802,000 581,000 -2,412,000 4,916,000 3,229,000 -320,000 36,603,000 -6,578,000 21,439,000 -7,519,000 13,494,000 23,165,000 24,749,000 12,927,000 59,440,000 -9,802,000 -22,716,000 31,456,000 10,444,000 6,129,000 57,674,000 9,067,000 -54,401,000 -31,112,000 -93,812,000 -18,588,000 -43,134,000 17,719,000 21,719,000 14,995,000 -100,454,000 
      partial repurchase of convertible senior notes
    		              0 0 0 -100,000                                                                             
      net cash from financing activities
    		             6,100,000 1,800,000 7,500,000 3,000,000 15,100,000 -179,400,000 2,500,000 15,800,000 3,300,000 7,284,000 13,164,000 4,284,000 2,581,000 1,782,000 5,490,000 6,123,000 16,135,000 5,600,000 3,022,000 506,493,000 1,531,000 63,000 1,329,000 936,000 62,000 968,000 740,000 1,759,000 273,525,000 1,732,000 484,000 274,000 136,241,000 50,000 2,661,000 1,625,000 966,000 288,000 118,000 43,000 83,253,000 22,000 45,000 162,000 57,000 99,000 22,000 3,000 21,359,000     -275,000 -325,000 -391,000 -461,000 60,118,000 -1,073,000 -699,000 -1,165,000 -1,145,000 -1,415,000 190,000 12,456,000 7,270,000 4,004,000 -19,000 -922,000 -740,000 11,170,000 13,788,000 12,474,000 14,788,000 189,111,000 2,746,000 4,414,000 2,755,000 1,756,000 1,327,000 -27,000 
      share-based compensation expense
    		              35,600,000 37,100,000 28,600,000 32,900,000 21,000,000 26,700,000 29,500,000 22,800,000 21,317,000 20,250,000 17,931,000 15,764,000                                  875,000 843,000 559,000  1,699,000 1,041,000 1,870,000  1,751,000 2,247,000 2,189,000  2,554,000 2,794,000 2,409,000  3,188,000 2,690,000 6,788,000                 
      issuance of common stock
    		                   2,500,000 15,800,000 3,300,000 7,284,000 13,164,000 4,284,000 2,581,000 1,782,000 5,490,000 6,123,000 16,135,000 5,600,000 3,022,000 3,712,000 1,531,000 63,000 1,329,000 936,000 62,000 968,000 740,000 1,759,000 273,525,000 1,732,000 484,000 274,000 136,241,000 50,000 2,661,000 1,625,000 966,000 288,000 118,000 43,000 83,253,000 22,000 45,000 162,000 57,000 99,000 22,000 3,000 21,359,000     1,000 0   16,000 2,000 500,000 73,000 206,000 44,000 1,689,000 13,910,000 8,774,000 5,645,000 1,755,000 796,000 1,596,000 1,352,000 2,038,000 1,777,000 882,000 189,051,000 2,633,000 4,047,000 1,509,000 554,000 851,000 545,000 
      other current assets and liabilities
    		                     -4,100,000                                                                         
      blank
    		                                                                                              
      net (accretion of discounts) amortization of premiums on investments
    		                      -499,000                                                                        
      change in fair value of restricted equity securities
    		                      7,182,000 28,450,000                                                                       
      other changes in operating assets and liabilities
    		                                                                                              
      purchases of marketable securities
    		                                                                                              
      sales and maturities of marketable securities
    		                                                                                              
      purchase of restricted equity securities
    		                      -14,135,000 0                                                                       
      proceeds from sales of property and equipment
    		                      0 4,000 0 4,000 4,000 0 12,000 18,000 0    0 0 10,000 3,000 0 0 0 9,000 0 0 5,000 40,000 2,000   13,000 7,000 0 0 25,000 58,000 86,000 18,000 83,000 94,000 35,000 61,000 146,000 239,000 609,000 33,000 312,000                             
      proceeds from issuance of convertible senior notes
    		                                                                                              
      depreciation and amortization
    		                       2,009,000 1,786,000 1,566,000 1,275,000 1,080,000 883,000 786,000 706,000 616,000 589,000 489,000 445,000 408,000 324,000 276,000 270,000 244,000 251,000 244,000 224,000 217,000 208,000 178,000 156,000 168,000 172,000 175,000 176,000 163,000 166,000 152,000 142,000 138,000 174,000 240,000 304,000 344,000 360,000 428,000 570,000 759,000 881,000 969,000 1,573,000 1,970,000 2,000,000 2,067,000 2,166,000 2,211,000 2,466,000 2,561,000 2,579,000 2,631,000 2,690,000 2,666,000     2,278,000 2,092,000 1,468,000 1,243,000         
      other current assets
    		                       -2,198,000 2,128,000 -2,110,000  -3,943,000 -2,144,000 -750,000 568,000 -1,878,000    -281,000    -1,244,000                                                       
      other liabilities
    		                       3,331,000 5,947,000 5,363,000    -28,000                     0 1,000 27,000 -1,000 1,000    101,000 0 -1,481,000 45,000                                 
      amortization of discounts/premiums on investments
    		                        -542,000 -290,000                                                                     
      change in fair value of investment in restricted equity securities
    		                         -1,680,000                                                                     
      purchases of investments
    		                         -116,307,000 -216,673,000 -105,213,000 -84,722,000 -139,354,000 -138,870,000 -79,506,000 -307,155,000 -57,877,000 -81,635,000 -47,653,000 -113,927,000 -55,561,000 -72,615,000 -89,577,000 -127,639,000 -159,221,000 -16,388,000 -32,819,000 -99,430,000 -108,907,000 -14,949,000 -34,767,000 -29,111,000 -66,501,000 -26,808,000 -16,344,000 -47,776,000 -75,385,000 -34,913,000 -28,307,000 -25,230,000 -50,649,000 -31,195,000 -31,870,000   -735,000 -719,000 -2,401,000 -12,945,000  -17,884,000                           
      sales and maturities of investments
    		                         215,936,000 116,423,000 72,477,000 54,839,000 84,086,000  46,911,000 94,239,000 116,085,000  91,626,000 100,396,000 126,754,000  42,009,000 74,221,000 43,398,000  36,304,000 41,678,000 43,391,000  33,487,000 50,349,000 31,470,000  27,334,000 19,907,000 30,548,000  46,668,000 25,533,000 29,453,000                                     
      investment in equity securities
    		                         -54,720,000                                                                     
      cash and cash equivalents and restricted cash at beginning of the period
    		                         147,191,000                                                                     
      cash and cash equivalents and restricted cash at end of the period
    		                         78,255,000                                                                     
      amortization of premiums on investments
    		                          13,000 372,000 552,000 512,000 554,000 606,000 327,000 269,000 369,000 711,000 1,043,000 1,397,000 1,721,000 1,732,000 1,568,000 1,011,000 1,047,000 1,151,000 977,000 617,000 735,000 750,000 719,000 639,000 655,000 990,000 867,000 623,000 569,000 619,000 652,000 501,000                                     
      deferred rent
    		                            -44,000 -28,000 -28,000 1,470,000 -125,000 -114,000 -86,000 -72,000 -72,000 -64,000 -41,000 -28,000 80,000 -27,000 -5,000 7,000 6,000 6,000 27,000 39,000 38,000 38,000 67,000 79,000 79,000 80,000 102,000 117,000 116,000 99,000 161,000 173,000 173,000 173,000 200,000 -50,000 323,000 323,000                             
      gain on sales of assets
    		                                                                                              
      cease-use expense
    		                              0 0   0 0 0 -584,000             957,000    -7,000 -87,000 76,000 100,000 2,398,000 120,000 134,000 147,000 126,000 89,000 941,000 4,828,000                             
      reimbursements for tenant improvements
    		                          5,044,000                                                                    
      proceeds from issuance of senior convertible notes
    		                              0 0                                                               
      net change in cash, cash equivalents, and restricted cash
    		                                                                                              
      cash, cash equivalents, and restricted cash at beginning of the period
    		                                                                                              
      cash, cash equivalents, and restricted cash at end of the period
    		                                                                                              
      supplemental disclosures
    		                                                                                              
      non-cash share-based compensation expense
    		                           13,070,000 11,851,000 19,879,000 13,452,000 10,204,000 9,890,000 8,976,000 7,953,000 6,319,000 7,274,000 6,918,000 6,226,000 13,903,000 4,663,000 3,600,000 2,444,000 2,664,000 2,827,000 2,447,000 1,696,000 1,711,000 1,680,000 1,732,000 1,310,000 1,370,000 1,373,000 1,426,000 907,000 904,000 395,000 712,000                                     
      other current liabilities
    		                           0                                                                   
      net increase in cash, cash equivalents and restricted cash
    		                           29,312,000                                                                   
      cash, cash equivalents and restricted cash at beginning of the period
    		                           0 0 259,212,000                                                                 
      cash, cash equivalents and restricted cash at end of the period
    		                           29,312,000 -7,912,000 179,811,000                                                                 
      gain on sale of assets
    		                            -147,000 -201,000 -156,000 -188,000 -881,000 -879,000 -863,000 -844,000 -868,000 -856,000 -838,000 -828,000 -829,000 -839,000 -812,000 -806,000 -810,000 -794,000 -788,000 -787,000 -800,000 -795,000 -773,000 -759,000 -759,000 -783,000 -3,011,000 -86,000 718,000 -816,000 -2,958,000 -35,000 -53,000 -115,000 -2,894,000 -570,000 -21,000 -141,000   -164,000 -34,000                         
      cease-use liability
    		                             -62,000 -59,000 -60,000 -62,000 -66,000 -61,000 -58,000 -71,000 -110,000 -83,000 -175,000 -239,000 -113,000 -110,000 -104,000 -102,000 -102,000 -102,000 -97,000 -197,000 -194,000 -70,000 -64,000 -65,000 -64,000 -4,340,000 -729,000 -1,219,000 -1,214,000 -1,140,000 -1,129,000 -1,123,000 -1,145,000 -5,872,000 -977,000 -995,000 -2,007,000                             
      net decrease in cash, cash equivalents and restricted cash
    		                             -79,401,000                                                                 
      cash flow from operating activities
    		                                                                                              
      deferred revenues
    		                                      0 0 0 10,231,000     -730,000 -729,000 -730,000 -730,000 -7,986,000 -7,990,000 -9,029,000 -9,237,000 -9,239,000 -9,238,000 -9,244,000 -9,306,000 75,828,000 -9,228,000 -3,364,000 -746,000 -717,000 -722,000 -731,000 -744,000 -719,000 -723,000 -730,000 -739,000 17,487,000 27,000 -27,000 36,000 -976,000 -477,000 -726,000 -4,358,000 -6,359,000 -5,448,000 -5,647,000 -5,683,000 -8,113,000 -7,163,000 -10,262,000 -12,695,000         
      cash flow from investing activities
    		                                                                                              
      sales/maturities of investments
    		                                                          24,807,000 3,872,000 580,000 5,580,000 6,585,000 7,830,000 2,960,000 10,240,000  20,945,000                           
      deposits and restricted cash
    		                              113,000 0 470,000 -200,000 0 0 108,000 -200,000 0 24,000           -1,000 0   1,822,000 -24,000 0 -2,000 231,000 -4,000 -2,000 -2,000 -3,000 92,000 -10,000 5,000    6,000                         
      cash flow from financing activities
    		                                                                                              
      net change in cash and cash equivalents
    		                                                                                              
      cash and cash equivalents at beginning of the year
    		                                                                                              
      cash and cash equivalents at end of the year
    		                                                                                              
      interest paid
    		                                                                                              
      taxes paid
    		                                                                                              
      other non-current liabilities
    		                                   0    -25,000                        152,000 -1,489,000 -299,000 -827,000 -494,000 -181,000 -74,000 -393,000 97,000 382,000 -30,000 54,000 258,000 -1,641,000 1,286,000 487,000 450,000 283,000 163,000 356,000            
      net increase in cash and cash equivalents
    		                               -41,680,000 245,411,000 -19,180,000  13,515,000 -29,055,000 41,106,000  -65,692,000 -38,192,000 139,248,000    60,743,000    -32,199,000    26,833,000 10,591,000 20,678,000 -5,555,000 -29,658,000 -23,279,000 -17,790,000 42,896,000 14,895,000    -16,802,000    7,975,000 49,314,000 -1,135,000 -26,972,000 -2,524,000 5,221,000 -10,408,000 -15,326,000 51,546,000 -25,436,000    -23,667,000   -67,845,000 -17,966,000   24,098,000   -3,458,000 -112,574,000 
      cash and cash equivalents at beginning of the period
    		                               0 0 83,267,000  0 0 74,195,000  0 0 31,014,000  0 0 44,789,000  0 0 63,754,000  0 0 50,107,000  0 0 54,051,000  0 0 37,329,000  0 0 68,467,000  0 0 99,664,000  0 0 80,981,000  0 0 49,948,000  0 0 61,027,000  0 0 105,854,000  0 0 44,313,000  0 0 163,888,000 
      cash and cash equivalents at end of the period
    		                               -41,680,000 245,411,000 64,087,000  13,515,000 -29,055,000 115,301,000  -65,692,000 -38,192,000 170,262,000  -8,399,000 -68,087,000 105,532,000  -9,424,000 12,758,000 31,555,000  2,470,000 -34,922,000 76,940,000  20,678,000 -5,555,000 24,393,000  -17,790,000 42,896,000 52,224,000  -3,299,000 -13,050,000 51,665,000  -11,792,000 -15,722,000 107,639,000  -1,135,000 -26,972,000 78,457,000  -10,408,000 -15,326,000 101,494,000  26,885,000 3,929,000 44,570,000  61,959,000 -15,274,000 38,009,000  88,924,000 -33,515,000 68,411,000  8,770,000 -3,458,000 51,314,000 
      supplemental cash flow information
    		                                                                                              
      cash paid for interest during the period
    		                                                                                              
      accounts receivable under collaboration agreements and other assets
    		                                 -779,000    -14,577,000    -30,552,000                                                     
      accounts receivable and other assets
    		                                                     -515,000 21,122,000 -19,617,000 67,000 1,241,000                                     
      net cash provided by/ (used in) investing activities
    		                                     70,255,000                                                         
      receivables under collaboration agreements and other assets
    		                                           -1,275,000 -1,046,000 850,000  -150,000 4,000 14,090,000  -339,000                                           
      net decrease in cash and cash equivalents
    		                                           -8,399,000    -9,424,000    2,470,000            -3,299,000    -11,792,000             3,929,000 -16,457,000             
      loss on sale of investments
    		                                                          0 0      320,000                             
      realized gain on sale of auction rate securities
    		                                                          -694,000 -35,000 -36,000 -555,000                                 
      fair value adjustment for auction rate security rights
    		                                                              150,000 258,000 196,000 211,000                             
      fair value adjustment of auction rate securities
    		                                                                                              
      other-than-temporary impairment for auction rate securities
    		                                                                                              
      interest paid on debt obligations
    		                                                                                              
      realized loss on sale of investments
    		                                                                                              
      deferred gain on sale of real estate
    		                                                       -736,000    -716,000 -714,000 -715,000  -695,000 -694,000 -695,000                             
      principal payments on debt
    		                                                                  -276,000 -325,000 -424,000 -461,000 -48,643,000 -1,075,000   -1,351,000 -1,459,000 -1,499,000 -1,454,000     -61,656,000 -1,186,000           
      supplemental disclosures of cash flow information:
    		                                                                                              
      fair value adjustment for trading auction rate security rights
    		                                                                                              
      fair value adjustment trading for auction rate securities
    		                                                                                              
      amortization of premiums on short term-investments
    		                                                           253,000      -10,000                             
      proceeds from sale of trading securities
    		                                                           9,100,000                                   
      accounts receivable and other current assets
    		                                                           -4,248,000 -298,000 -167,000  -55,000 -188,000 121,000 911,000 -133,000 730,000 1,105,000 -216,000 -49,000 224,000 7,532,000 -6,052,000 1,306,000 3,925,000 -3,991,000 548,000 21,467,000 -18,130,000 2,559,000 -375,000 -2,194,000 -200,000 8,724,000         
      other assets
    		                                                                                              
      upfront licensing fees
    		                                                           10,000,000                                   
      fair value adjustment for auction rate securities
    		                                                               -330,000 -425,000 1,237,000                             
      loss/(gain) on sale of investments
    		                                                                                              
      asset impairment
    		                                                                                              
      loan forgiveness on notes receivable
    		                                                                              69,000 0   70,000 78,000           
      non-cash stock compensation expense
    		                                                                                              
      leaseback financing obligation
    		                                                                                              
      amortization of premiums/discounts on short term-investments
    		                                                               0                               
      other non-current assets
    		                                                               -6,000 1,810,000 189,000 -172,000 14,000 112,000 -139,000 -22,000 -606,000 18,000 76,000 413,000 -176,000 -184,000 -529,000 -199,000 -49,000 -53,000 -335,000   287,000 300,000         
      gain on sale of investments
    		                                                                                              
      (gain)/loss on sale/abandonment of assets
    		                                                                                              
      (gain)/loss on sale of investments
    		                                                                                              
      purchases of short-term investments
    		                                                                     -9,984,000 -44,172,000 -1,819,000 -9,651,000 -38,996,000 -1,523,000 317,000 -1,817,000 -61,021,000 -333,307,000 -29,552,000 580,000 -20,550,000 -7,210,000 -64,706,000 -182,368,000 -289,438,000 -85,855,000 -148,688,000 -101,071,000 -112,680,000 -69,731,000 -100,449,000 -49,843,000 -181,566,000 
      sales/maturities of short-term investments
    		                                                                     46,688,000 38,885,000 23,450,000 2,240,000 52,555,000 24,249,000 24,714,000 16,764,000 121,183,000 326,478,000 8,506,000 31,954,000 33,033,000 5,940,000 130,050,000 207,959,000 301,100,000 57,582,000 65,775,000 103,853,000 73,280,000 88,756,000 123,693,000 66,915,000 81,504,000 
      gain on sale and disposal of assets
    		                                                                                              
      realized loss on auction rate securities
    		                                                                                              
      restricted cash
    		                                                                   127,000                           
      sale of property and equipment
    		                                                                   71,000 276,000 174,000                         
      non-cash compensation expense
    		                                                                                              
      payments received on notes receivable from employees
    		                                                                                              
      (gain)/loss on disposal of fixed assets
    		                                                                                              
      loan forgiveness on notes receivable from stockholder
    		                                                                           0                   
      proceeds from the sale of property and equipment
    		                                                                                              
      sales force allowance prepayment
    		                                                                             8,240,000                 
      principal payments on long-term obligations
    		                                                                         -1,238,000        -1,718,000    -1,004,000  -14,840,000 -721,000 -646,000 -573,000 -592,000 -576,000 -572,000 
      loss on sale/abandonment of assets
    		                                                                                              
      deferred expenses
    		                                                                                  997,000 -137,000 -24,000 164,000         
      purchase of prepaid royalty stream
    		                                                                                              
      proceeds received from debt
    		                                                                                              
      tax benefit from exercise of stock options
    		                                                                                              
      stock issued for prepaid royalty
    		                                                                                              
      loss on disposal of fixed assets
    		                                                                                              
      operating activities
    		                                                                                              
      investing activities
    		                                                                                              
      financing activities
    		                                                                                              
      gain on sale/abandonment of assets
    		                                                                                              
      proceeds from sale of property and building
    		                                                                                              
      non-cash compensation expenses
    		                                                                               107,000 105,000 209,000  134,000 148,000 132,000         
      purchase of royalty stream
    		                                                                                   0 0 -50,000,000         
      deposit and restricted cash
    		                                                                               0 0 -525,000             
      proceeds from debt financing
    		                                                                                     11,701,000         
      principal payments on long-term debt
    		                                                                               -1,641,000               
      supplemental information:
    		                                                                                              
      increase in stockholder’s equity and prepaid royalties from issuance of common stock
    		                                                                                              
      as reported
    		                                                                                              
      stock option expense
    		                                                                                              
      pro forma net income
    		                                                                                              
      payments received on notes receivable from stockholders
    		                                                                                          0    
      restricted cash and other non-current assets
    		                                                                                              
      deposits
    		                                                                                   -550,000    0       
      proceeds received from issuance of debt
    		                                                                                              
      increase in property and related debt resulting from increasing ownership percentage in science park center llc
    		                                                                                              
      net income:
    		                                                                                              
      loss per share as reported
    		                                                                                              
      pro forma loss per share
    		                                                                                              
      deposit
    		                                                                                     7,988,000    -2,500,000     
      (gain) loss on sale/abandonment of assets
    		                                                                                              
      proceeds from issuance of long-term debt
    		                                                                                              
      proceeds from capital lease financing
    		                                                                                        834,000 1,013,000  1,690,000   
      increase in property and related debt resulting form increasing ownership percentage in science park center llc
    		                                                                                              
      adjustments to reconcile net income to net cash
    		                                                                                              
      used in operating activities:
    		                                                                                              
      loss on abandonment of assets
    		                                                                                              
      loan forgiveness on notes receivable from stockholders
    		                                                                                              
      proceeds received from long-term obligations
    		                                                                                              
    The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.