7Baggers
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 2004-03-31 2003-12-31 2003-09-30 2003-06-30 2003-03-31 2002-12-31 2002-09-30 2002-06-30 2002-03-31 
      
                                                                                                  
      revenues:
                                                                                                  
      net product sales
    789,900,000 682,000,000 563,700,000 616,600,000 583,800,000 509,000,000 507,200,000 491,800,000 446,300,000 415,300,000 259,075,000 379,300,000 352,000,000 305,000,000 196,650,000 288,800,000                                                                               
      collaboration revenues
    5,000,000 5,500,000 8,900,000 5,500,000 6,400,000 6,300,000 4,625,000 7,000,000 6,400,000 5,100,000 10,100,000 8,600,000 26,200,000 5,600,000 8,725,000 7,200,000                                                                               
      total revenues
    794,900,000 687,500,000 572,600,000 622,100,000 590,200,000 515,300,000 515,200,000 498,800,000 452,700,000 420,400,000 412,000,000 387,900,000 378,200,000 310,600,000 312,000,000 296,000,000 288,900,000 236,600,000 247,900,000 258,500,000 302,400,000 237,100,000 244,010,000 222,094,000 183,580,000 138,403,000 131,492,000 151,757,000 96,905,000 71,086,000 94,517,000 60,774,000 6,335,000     15,000,000    19,769,000     730,000 729,000 730,000 730,000 21,947,000 9,357,000 10,569,000 11,267,000 11,110,000 41,634,000 12,157,000 12,512,000 13,657,000 14,448,000 4,643,000 753,000 740,000 733,000 733,000 747,000 729,000 761,000 734,000 1,751,000 532,000 540,000 48,000 104,000 9,440,000 1,074,000 9,244,000 19,476,000 14,111,000 64,745,000 33,169,000 11,864,000 18,485,000 34,701,000 15,049,000 16,941,000         
      operating expenses:
                                                                                                  
      cost of revenues
    14,000,000 11,300,000 9,200,000 8,000,000 9,200,000 7,500,000 8,500,000 11,200,000 11,500,000 8,500,000 7,700,000 6,100,000 4,800,000 4,600,000                                                                                 
      research and development
    250,000,000 244,300,000 263,200,000 195,000,000 191,100,000 159,400,000 137,500,000 142,200,000 145,800,000 139,500,000 118,000,000 107,700,000 135,900,000 102,200,000 87,400,000 92,700,000 74,800,000 73,200,000 66,700,000 69,100,000 80,900,000 58,300,000 55,425,000 45,278,000 61,687,000 37,652,000 39,107,000 35,482,000 36,988,000 48,947,000 25,614,000 22,463,000 21,868,000 51,882,000 22,583,000 20,942,000 26,863,000 23,903,000 21,809,000 24,388,000 18,719,000 16,575,000 15,498,000 12,194,000 10,161,000 8,572,000 8,918,000 9,490,000 10,527,000 10,313,000 9,097,000 9,860,000 8,818,000 9,388,000 8,002,000 7,456,000 8,176,000 7,317,000 8,065,000 8,227,000 7,283,000 7,576,000 6,753,000 7,401,000 10,808,000 10,848,000 11,885,000 12,993,000 16,186,000 14,227,000 24,340,000 19,795,000 18,789,000 19,061,000 18,608,000 25,223,000 26,112,000 27,735,000 24,765,000 26,627,000 29,633,000 25,603,000 33,404,000 32,305,000 22,969,000 26,388,000 39,087,000 37,537,000  48,324,000 41,565,000 24,231,000 23,096,000 20,047,000 
      acquired in-process research and development
    300,000  100,000 1,000,000 2,500,000 6,000,000    143,900,000     100,300,000  5,000,000   118,500,000 46,000,000  36,191,000  5,000,000 113,081,000                                                                     
      selling, general, and administrative
    291,600,000 286,300,000 276,500,000 234,300,000                                                                                           
      total operating expenses
    555,900,000 541,900,000 549,000,000 438,300,000 444,800,000 416,000,000 364,900,000 357,600,000 379,100,000 534,600,000 308,600,000 300,100,000 323,500,000 307,500,000 348,300,000 251,500,000 226,100,000 205,100,000 176,100,000 302,800,000 225,800,000 178,200,000 195,289,000 131,996,000 149,119,000 239,400,000 109,621,000 97,434,000 98,757,000 108,533,000 82,683,000 66,769,000 63,603,000 79,932,000 46,251,000 38,436,000 41,828,000 35,857,000 30,748,000 35,844,000 25,322,000 22,057,000 20,468,000 16,857,000 14,361,000 12,725,000 12,260,000 12,735,000 13,897,000 13,705,000 13,365,000 13,319,000 11,949,000 13,059,000 10,663,000 11,194,000 11,061,000 10,573,000 13,786,000 11,982,000 10,533,000 10,922,000 9,720,000 10,456,000 16,576,000 19,871,000 31,444,000 16,465,000 20,851,000 22,513,000 129,126,000 29,366,000 27,596,000 27,378,000 25,703,000 41,270,000 38,508,000 47,070,000 38,705,000 39,624,000 39,421,000 31,211,000 39,669,000 37,732,000 28,438,000 31,671,000         
      operating income
    239,000,000 145,600,000 23,600,000 183,800,000 145,400,000 99,300,000 150,300,000 141,200,000 73,600,000 -114,200,000 103,400,000 87,800,000 54,700,000 3,100,000 -36,300,000 44,500,000 62,800,000 31,500,000 71,800,000 -44,300,000 76,600,000 58,900,000 48,721,000 90,098,000 34,461,000 -100,997,000                                                                     
      yoy
    64.37% 46.63% -84.30% 30.17% 97.55% -186.95% 45.36% 60.82% 34.55% -3783.87% -384.85% 97.30% -12.90% -90.16% -150.56% -200.45% -18.02% -46.52% 47.37% -149.17% 122.28% -158.32%                                                                         
      qoq
    64.15% 516.95% -87.16% 26.41% 46.42% -33.93% 6.44% 91.85% -164.45% -210.44% 17.77% 60.51% 1664.52% -108.54% -181.57% -29.14% 99.37% -56.13% -262.08% -157.83% 30.05% 20.89% -45.92% 161.45% -134.12%                                                                      
      operating margin %
                                                                                                  
      other income:
                                                                                                  
      unrealized gain on equity investments
    30,600,000  -30,600,000                                                                                            
      charges associated with convertible senior notes
        -49,700,000 -88,700,000                                                                                         
      investment income and other
    22,200,000 20,600,000 21,700,000 23,400,000 22,800,000 23,400,000 20,000,000 15,600,000 12,000,000 9,800,000 8,400,000 200,000 1,600,000 1,000,000 700,000 800,000 900,000 1,400,000 1,600,000 2,700,000 3,600,000 4,700,000 5,229,000 4,797,000 4,607,000 4,576,000 4,700,000 4,113,000 3,347,000                                                                  
      total other income
    52,800,000 13,900,000 -8,900,000 6,500,000 -46,800,000 -64,800,000 47,900,000 -25,600,000 48,000,000 10,900,000 14,500,000 10,100,000 -78,000,000 18,300,000 22,500,000 -14,000,000 -5,300,000 -4,300,000 -30,100,000 -12,800,000 6,600,000 -20,000,000 -10,083,000 -31,691,000 17,630,000 -1,597,000 -3,063,000 -3,559,000 -4,061,000 -4,371,000 -4,940,000 -5,130,000 -2,717,000 1,606,000 1,592,000 1,549,000 1,548,000 1,593,000 1,433,000 1,409,000 1,335,000 1,096,000 1,024,000 982,000 980,000 883,000 888,000 875,000 925,000 900,000 908,000 884,000 879,000 906,000 884,000 942,000 880,000 943,000 784,500 867,000 738,000 1,533,000    -541,000 1,861,000 -2,007,000 -854,000 -315,000 619,000 1,586,000 1,184,000 1,554,000 1,551,000 1,053,000 1,815,000 1,693,000 686,000 1,030,000 648,000 517,000 647,000 1,382,000 2,258,000 2,353,000         
      income before benefit from income taxes
    291,800,000 159,500,000 14,700,000 190,300,000 98,600,000 34,500,000 198,200,000 115,600,000 121,600,000 -103,300,000 117,900,000 97,900,000 -23,300,000 21,400,000 -13,800,000 30,500,000 57,500,000 27,200,000 41,700,000 -57,100,000 83,200,000 38,900,000 38,638,000 58,407,000 52,091,000 -102,594,000                                                                     
      benefit from income taxes
    82,300,000 52,000,000 6,800,000 60,500,000 33,600,000 -8,900,000 50,500,000 32,500,000 26,100,000  28,900,000 29,400,000  7,500,000 -6,500,000 8,000,000 15,200,000  1,400,000 500,000 3,600,000 1,500,000 4,638,000 4,618,000 753,000 -479,000                                                                     
      net income
    209,500,000 107,500,000 7,900,000 129,800,000 65,000,000 43,400,000 147,700,000 83,100,000 95,500,000 -76,600,000 89,000,000 68,500,000 -16,900,000 13,900,000 -7,300,000 22,500,000 42,300,000 32,100,000 347,900,000 -57,600,000 79,600,000 37,400,000 34,000,000 53,789,000 51,338,000 -102,115,000 18,078,000 50,764,000 -5,913,000 -41,818,000 6,894,000 -11,125,000 -59,985,000 -78,326,000 -44,659,000 -36,887,000 -40,280,000 -19,264,000 -29,315,000 -34,435,000 -23,987,000 -1,192,000 -19,444,000 -15,875,000 -13,381,000 -11,842,000 -10,642,000 -11,131,000 -12,242,000 -12,075,000 9,490,000 -3,078,000 -501,000 -886,000 1,331,000 31,382,000 1,976,000 2,882,000 2,487,000 3,333,000 -5,152,000 -8,636,000 -7,916,000 -8,177,000 -15,280,000 -19,665,000 -28,854,000 -17,711,000 -20,971,000 -21,077,000 -127,975,000 -27,240,000 -26,364,000 -25,720,000 -14,712,000 -39,143,000 -27,449,000 -25,901,000 -23,908,000 26,151,000 -5,604,000 -18,830,000 -20,615,000 -1,647,000 -11,131,000 -12,380,000 3,193,000 -9,834,000 -10,225,000 -13,390,000 -38,787,000 -20,234,000 -19,751,000 -15,764,000 
      yoy
    222.31% 147.70% -94.65% 56.20% -31.94% -156.66% 65.96% 21.31% -665.09% -651.08% -1319.18% 204.44% -139.95% -56.70% -102.10% -139.06% -46.86% -14.17% 923.24% -207.09% 55.05% -136.63% 88.07% 5.96% -968.22% 144.19% 162.23% -556.31% -90.14% -46.61% -115.44% -69.84% 48.92% 306.59% 52.34% 7.12% 67.92% 1516.11% 50.77% 116.91% 79.26% -89.93% 82.71% 42.62% 9.30% -1.93% -212.14% 261.63% 2343.51% 1262.87% 613.00% -109.81% -125.35% -130.74% -46.48% 841.55% -138.35% -133.37% -131.42% -140.76% -66.28% -56.08% -72.57% -53.83% -27.14% -6.70% -77.45% -34.98% -20.46% -18.05% 769.87% -30.41% -3.95% -0.70% -38.46% -249.68% 389.81% 37.55% 15.97% -1687.80% -49.65% 52.10% -745.63% -83.25% 8.86% -7.54% -108.23% -51.40% -48.23% -15.06%     
      qoq
    94.88% 1260.76% -93.91% 99.69% 49.77% -70.62% 77.74% -12.98% -224.67% -186.07% 29.93% -505.33% -221.58% -290.41% -132.44% -46.81% 31.78% -90.77% -703.99% -172.36% 112.83% 10.00% -36.79% 4.77% -150.27% -664.86% -64.39% -958.52% -85.86% -706.59% -161.97% -81.45% -23.42% 75.39% 21.07% -8.42% 109.09% -34.29% -14.87% 43.56% 1912.33% -93.87% 22.48% 18.64% 13.00% 11.28% -4.39% -9.08% 1.38% -227.24% -408.32% 514.37% -43.45% -166.57% -95.76% 1488.16% -31.44% 15.88% -25.38% -164.69% -40.34% 9.10% -3.19% -46.49% -22.30% -31.85% 62.92% -15.55% -0.50% -83.53% 369.81% 3.32% 2.50% 74.82% -62.41% 42.60% 5.98% 8.34% -191.42% -566.65% -70.24% -8.66% 1151.67% -85.20% -10.09% -487.72% -132.47% -3.82% -23.64% -65.48% 91.69% 2.45% 25.29%  
      net income margin %
                                                                                                  
      foreign currency translation adjustments, net of tax
    1,600,000 800,000 1,500,000 2,900,000 100,000 -500,000 1,700,000 -1,400,000 900,000 1,200,000                                                                                     
      unrealized gain on available-for-sale debt securities, net of tax
    -900,000 2,700,000 1,700,000 9,100,000                   884,500 961,000 878,000                                                                      
      comprehensive income
    210,200,000 111,000,000 11,100,000 141,800,000 64,200,000 39,700,000 156,400,000 82,500,000 97,100,000 -71,400,000 95,100,000 66,700,000 -19,800,000 6,300,000 -9,400,000 22,200,000 42,000,000 31,300,000 346,500,000 -59,000,000 85,600,000 34,600,000 33,807,000 54,750,000 52,216,000  -2,805,971 51,517,000                       9,469,000 -2,916,000 -517,000 -926,000                                         
      earnings per share:
                                                                                                  
      basic
    2.11 1.09 0.08 1.28 0.64 0.43 0.263 0.85 0.98 -0.79 0.173 0.72 -0.18 0.15                                                                                 
      diluted
    2.04 1.06 0.08 1.24 0.63 0.42 0.253 0.82 0.95 -0.79 0.168 0.69 -0.18 0.14                                                                                 
      weighted-average shares outstanding:
                                                                                                  
      basic
    99.4 99 99.7 101.1 100.8 99.8  97.9 97.6 97.1  95.8 95.6 95.3                                                                                 
      diluted
    102.5 101 102.5 104.3 103.9 103.6  101.1 100.2 97.1  99 95.6 97.6                                                                                 
      unrealized loss on equity investments
     -6,700,000  -16,900,000                                                                                           
      selling, general and administrative
        242,000,000 243,100,000 218,900,000 204,200,000 221,800,000 242,700,000 182,900,000 186,300,000 182,800,000 200,700,000 156,500,000 154,600,000 143,200,000 129,000,000 106,500,000 112,500,000 96,500,000 117,800,000 63,212,750 84,489,000 80,824,000 87,538,000                                                                     
      unrealized gain on equity securities
        -19,900,000      7,200,000 11,100,000 -7,400,000 19,900,000       11,300,000                                                                          
      unrealized gain on debt securities available-for-sale, net of tax
        -900,000 -3,200,000 7,000,000 800,000 700,000 4,000,000     -350,000 -300,000 -300,000  450,000 -1,400,000 6,000,000 -2,800,000                                                                         
      interest expense
         -1,100,000 -1,100,000 -1,100,000 -1,300,000 -1,100,000 -1,100,000 -1,200,000 -2,200,000 -2,600,000 -6,600,000 -6,600,000 -6,200,000 -6,400,000 -7,800,000 -8,500,000 -8,300,000 -8,200,000 -8,130,000 -8,038,000 -7,942,000 -7,853,000 -7,763,000 -7,672,000 -7,591,000 -7,504,000 -7,419,000 -7,337,000 -4,767,000                                  -1,437,250 -1,914,000 -1,914,000 -1,921,000 -636,250 -827,000 -848,000 -870,000 -893,000 -917,000 -943,000 -969,000 -996,000 -1,024,000 -1,054,000 -1,084,000 -1,054,000 -722,000 -185,000  2,000   -136,000 -118,000 -175,000 -91,000 -101,000 
      unrealized gain on equity security investments
         1,600,000 -150,000 -40,100,000 37,300,000 2,200,000                                                                                     
      loss on extinguishment of convertible senior notes
                -70,000,000                                                                                  
      (benefit from) benefit from income taxes
             -26,700,000   -6,400,000     -4,900,000                                                                             
      unrealized loss on debt securities available-for-sale, net of tax
              -3,075,000 -1,800,000 -2,900,000 -7,600,000    -800,000                                                                             
      cost of sales
                  4,100,000 4,200,000 3,100,000 2,900,000 2,900,000 2,700,000 2,400,000 2,100,000 2,462,000 2,229,000 1,608,000 1,129,000 1,534,000 1,551,000                                                                   
      gross profit
                                                                                                  
      yoy
                                                                                                  
      qoq
                                                                                                  
      gross margin %
                                                                                                  
      unrealized loss on equity securities
                  -1,875,000 -8,200,000   -3,050,000 -7,000,000                                                                           
      net income per share
                  0.258 0.24 0.45 0.34 3.74 -0.62 0.86 0.4 0.37 0.59 0.56 -1.12                                                                     
      weighted-average common shares outstanding, basic
          97.7    95.8    94.6 94.7 94.6 94.2 93.1 93.3 93 92.6 91,627 91,859 91,389  90,235                                                                    
      weighted-average common shares outstanding, diluted
          101    98.9    97.9 97.7 97.7 98.2 97.8 93.3 98.2 97 95,732 96,074 94,779  95,386                                                                    
      product sales
                    266,800,000 231,000,000 241,300,000 254,100,000 267,600,000 231,100,000 237,831,000 198,094,000 180,544,000 136,431,000 130,326,000 111,291,000 96,905,000 71,086,000 64,517,000 45,774,000 6,335,000                                                              
      collaboration revenue
                    22,100,000 5,600,000 6,600,000 4,400,000 34,800,000 6,000,000 6,179,000 24,000,000 3,036,000 1,972,000 1,166,000 40,466,000                                                                   
      unrealized gain on restricted equity securities
                     700,000       20,965,000                                                                      
      unrealized losses (gains) on equity securities
                         -16,500,000                                                                         
      unrealized loss on restricted equity securities
                          -7,182,000 -28,450,000                                                                       
      unrealized gain on investment in restricted equity securities
                             1,680,000                                                                     
      unrealized gain on available-for-sale securities, net of tax
                             1,699,000                                                                     
      comprehensive loss
                             -100,416,000   -5,025,000 -43,665,000 5,578,000 -10,946,000 -60,463,000 -78,243,000 -44,790,000 -37,035,000 -40,131,000 -18,475,000 -29,683,000 -34,640,000 -24,212,000 -1,094,000 -10,327,500 -15,956,000 -13,313,000 -12,041,000 -8,863,750 -11,096,000 -12,242,000 -12,117,000                                             
      weighted-average common shares outstanding, basic and diluted
                             91,056                                                                     
      sales, general and administrative
                              68,980,000 60,401,000 60,915,000 58,636,000 56,309,000 43,873,000 41,674,000                                      10,786,000 9,571,000 8,807,000 8,317,000 7,095,000 16,047,000 12,396,000 19,335,000 13,940,000 12,997,000 9,788,000 5,608,000             
      income from operations
                              21,871,000 54,323,000 -1,852,000 -37,447,000 11,834,000 -5,995,000 -57,268,000 -79,932,000 -46,251,000 -38,436,000 -41,828,000 -20,857,000 -30,748,000 -35,844,000 -25,322,000 -2,288,000 -20,468,000 -16,857,000 -14,361,000 -12,725,000 -11,530,000 -12,006,000 -13,167,000 -12,975,000 8,582,000 -3,962,000 -1,380,000 -1,792,000 447,000 30,440,000 1,096,000 1,939,000 -129,000 2,466,000 -5,890,000 -10,169,000 -8,980,000 -9,723,000 -15,843,000 -19,124,000 -30,715,000 -15,704,000 -20,117,000 -20,762,000 -128,594,000 -28,826,000 -27,548,000 -27,274,000 -16,263,000 -40,196,000 -29,264,000 -27,594,000 -24,594,000 25,121,000 -6,252,000 -19,347,000 -21,184,000 -3,031,000 -13,389,000 -14,730,000 -17,371,000 -13,574,000 -12,490,000 -15,352,000 -41,273,000 -22,501,000 -22,020,000 -17,821,000 
      net income per common share:
                                                                                                  
      basic
                              -29.77 560                       150 -50 -10 -10 20 570 40 50 -50 60               -615 -1,030   12.5 710           -457.5 -660   
      diluted
                              -29.78 520                       150 -50 -10 -10 30 560 40 50 -50 60               -615 -1,030   12.5 680           -457.5 -660   
      shares used in the calculation of net income per common share:
                                                                                                  
      basic
                              22,516,000 90,555,000                       264,000 66,342,000 66,309,000 63,409,000 28,000 55,248,000 55,209,000 54,983,000 13,032,500 54,844,000               9,416,000 37,868,000   9,171,250 36,707,000           7,611,750 30,522,000   
      diluted
                              23,818,000 96,798,000                       1,591,000 66,342,000 66,309,000 63,409,000 38,000 56,378,000 56,434,000 56,114,000 13,032,500 55,648,000               9,416,000 37,868,000   9,498,000 38,406,000           7,611,750 30,522,000   
      other comprehensive income:
                                                                                                  
      net unrealized gain on available-for-sale securities
                              -51,500 753,000 888,000                                                                  
      cost of product sales
                                854,000 950,000 760,000 433,000 61,000                                                              
      deferred gain on real estate
                                183,000 201,000 183,000 183,000 879,000 879,000 863,000 853,000 854,000 853,000 838,000 828,000 829,000 830,000 812,000 805,000 805,000 804,000 789,000 781,000 781,000 782,000 766,000 759,000 759,000 758,000 744,000 736,000 737,000 736,000 722,000 715,000 715,000    694,000 695,000                             
      net income per common share:
                                                                                                  
      basic and diluted
                                -70 -470 -425 -130 -680 -900 -277.5 -430 -460 -220 -177.5 -400 -280 -10 -140 -210 -180 -170 -132.5 -170 -180 -180           -90 -190 -190 -210 -390 -510 -740 -460 -550 -550 -3,360 -720 -690 -680   -730 -690   -150 -510 -560 -50 -310 -350 -0.268 -0.31  -430   -650  
      shares used in the calculation of net income per common share:
                                                                                                  
      basic and diluted
                                90,100,000 89,526,000 21,973,500 88,325,000 88,063,000 87,283,000 21,664,750 86,784,000 86,694,000 86,497,000 20,981,750 85,856,000 85,518,000 80,349,000 18,512,500 75,948,000 75,879,000 70,260,000 16,717,000 67,199,000 66,799,000 66,600,000           54,836,000 46,618,000 199,000 39,096,000 39,046,000 38,669,000 50,000 38,446,000 38,421,000 38,330,000 53,000 37,990,000 37,969,000 37,908,000   37,764,000 37,355,000   36,647,000 36,598,000 93,000 36,427,000 36,368,000 35,527,000 32,342,603 32,053  30,789,000   30,433,000 30,384,000 
      other comprehensive loss:
                                                                                                  
      investment income
                                 2,932,000 2,323,000 2,019,000 1,169,000 727,000 716,000 705,000 680,000 737,000 584,000 581,000 506,000 257,000 197,000 176,000 167,000 89,000 85,000 93,000 121,000 103,000 130,000 123,000 115,000 121,000 85,250 102,000  119,000                                     
      net unrealized gains on available-for-sale securities
                                 -1,847,000    83,000    789,000     -70,000 -81,000 68,000  14,000 35,000   -21,000 162,000 -16,000                                          
      license fees and milestones
                                  3,750,000 15,000,000   3,750,000   15,000,000                     3,331,250 9,238,000 3,357,000 730,000 547,500 730,000 730,000 730,000 797,250 729,000 730,000 1,730,000 125,000 500,000   1,702,750 726,000 727,000 5,358,000 21,836,000 55,448,000 25,448,000 6,448,000 12,450,750 26,096,000 12,388,000  7,326,500 11,319,000       
      other income, net:
                                                                                                  
      gain/(loss) on sale/disposal of assets
                                  1,750 5,000       2,250                                                        
      net unrealized gains/(losses) on available-for-sale securities
                                  -54,000 179,000   197,500 -148,000 149,000     98,000                                                     
      gain on sale/disposal of assets
                                    2,000   -9,000 14,000 3,000    9,000  1,000 5,000 -10,000 -1,000 6,000 19,000 13,000 7,000   25,000 58,000 86,000 18,000 80,000 92,000 34,000 53,000 115,000 2,893,000 571,000 21,000 141,000                             
      net unrealized (losses)/gains on available-for-sale securities
                                    -478,000        -225,000                                                      
      general and administrative
                                     28,050,000 23,668,000 17,494,000 14,965,000 11,954,000 8,939,000 11,456,000 6,603,000 5,482,000 4,970,000 4,663,000 4,200,000 4,153,000 3,342,000 3,245,000 3,370,000 3,392,000 3,311,000 3,324,000 3,131,000 3,671,000 2,668,000 3,825,000 2,809,000 3,156,000 3,323,000 3,635,000 3,116,000 3,199,000 2,841,000 2,966,000 4,827,000 4,195,000 4,105,750 3,472,000 4,665,000 8,286,000             6,265,000 5,427,000 5,469,000 5,283,000 5,419,000 5,296,000  4,744,000 3,586,000 3,253,000 3,151,000 2,731,000 
      license fees
                                          4,942,250   19,769,000     547,250 729,000 730,000 730,000                                    11,319,000    6,667,000 436,750 581,000 583,000 583,000 
      other income
                                              15,000  3,000  15,000 -5,000 4,000 2,000 5,000 2,000 5,000 2,000 5,000 18,000 5,000 8,000 996,000  35,000 24,000 1,188,000 111,000 -558,000 -283,000         -118,000 -472,000       -136,000 2,000      48,000     
      net unrealized losses on available-for-sale securities
                                          -83,000 -205,000      -199,000    -42,000    -40,000                                         
      sponsored research and development
                                                      13,959,000 1,369,000 1,540,000 2,029,000 1,873,000 2,396,000 2,919,000 3,274,000 4,419,000 5,210,000 1,286,000 23,000 11,000 3,000 3,000 17,000 -1,000 32,000 4,000 12,000 19,000 13,000 21,000 86,000 213,000 348,000 277,000 5,878,000 753,000 1,297,000 2,721,000 4,416,000 10,676,000 8,605,000 2,506,000 5,369,000 15,048,000 17,580,000  30,725,000 1,652,000 3,574,000 3,180,000 3,958,000 
      cease-use expense
                                                      957,000 135,000   -7,000 -87,000 76,000 100,000    147,000    4,828,000                             
      milestones and license fees
                                                      7,988,000 7,988,000 9,029,000 9,238,000 9,237,000 39,238,000 9,238,000 9,238,000                                     
      investment income and (expense)
                                                            120,000  183,000 118,000 -65,000                                  
      cease use expense
                                                              100,250 120,000 134,000  1,464,500 89,000 941,000                              
      deferred gain on sale of real estate
                                                                 715,000 521,000 694,000                               
      investment income and
                                                                 679,000                                 
      grant revenue
                                                                      2,250   9,000 18,000 27,000 27,000 18,000                     
      other income and
                                                                                                  
      gain on auction rate securities
                                                                  -286,750 71,000 230,000                              
      interest income
                                                                  157,250 99,000 176,000 354,000         1,972,000 2,442,000 2,758,000 2,662,000 1,645,000 2,080,000 1,713,000 1,601,000 1,837,000 2,102,000 2,444,000 2,353,000 2,599,000 3,724,000  2,201,000 2,564,000 2,458,000 2,282,000 2,045,000 
      total other income net
                                                                  392,000 1,546,000 563,000                              
      loss on auction rate securities
                                                                     -1,448,000                             
      interest income and other income
                                                                      643,250 -93,000 1,060,000 1,606,000 1,717,250 2,413,000 2,032,000 2,424,000                     
      sales force allowance
                                                                                8,240,000 8,240,000 8,000,000 8,000,000 5,000,000              
      other income and (expense)
                                                                                  -9,250 -26,000 -11,000    -1,000  30,750 19,000       
      grant income
                                                                                        155,000 253,000 246,500 360,000  324,000 364,500 578,000 464,000  
      income before income taxes
                                                                                  429,250 26,151,000 -5,604,000  -6,289,250 -1,649,000 -11,131,000  -8,323,250 -9,831,000 -10,223,000      
      income taxes
                                                                                      78,000 -2,000   2,000 3,000 2,000      
      sales allowance
                                                                                     1,000,000             
      interest income and
                                                                                                  
      income before income tax expense
                                                                                     -18,830,000    -12,377,000    -13,239,000     
      income tax expense
                                                                                         3,000    151,000     
      net income per share
                  0.258 0.24 0.45 0.34 3.74 -0.62 0.86 0.4 0.37 0.59 0.56 -1.12                                                                     
      basic and diluted
                                -70 -470 -425 -130 -680 -900 -277.5 -430 -460 -220 -177.5 -400 -280 -10 -140 -210 -180 -170 -132.5 -170 -180 -180           -90 -190 -190 -210 -390 -510 -740 -460 -550 -550 -3,360 -720 -690 -680   -730 -690   -150 -510 -560 -50 -310 -350 -0.268 -0.31  -430   -650  
      shares used in the calculation of net income per share:
                                                                                                  
      basic and diluted
                                90,100,000 89,526,000 21,973,500 88,325,000 88,063,000 87,283,000 21,664,750 86,784,000 86,694,000 86,497,000 20,981,750 85,856,000 85,518,000 80,349,000 18,512,500 75,948,000 75,879,000 70,260,000 16,717,000 67,199,000 66,799,000 66,600,000           54,836,000 46,618,000 199,000 39,096,000 39,046,000 38,669,000 50,000 38,446,000 38,421,000 38,330,000 53,000 37,990,000 37,969,000 37,908,000   37,764,000 37,355,000   36,647,000 36,598,000 93,000 36,427,000 36,368,000 35,527,000 32,342,603 32,053  30,789,000   30,433,000 30,384,000 
      net income per common share:
                                                                                                  
      shares used in the calculation of net
                                                                                                  
      loss per common share:
                                                                                                  
      milestones
                                                                                              62,500 250,000   
      other income and (expenses)
                                                                                              43,750 -16,000 78,000  
      grant income and other revenues
                                                                                                 416,000 
      other income and expenses
                                                                                                 113,000 
      loss per common share:
                                                                                                  
      basic and diluted
                                                                                                 -520 
      shares used in the calculation of loss per common share:
                                                                                                  
      basic and diluted
                                90,100,000 89,526,000 21,973,500 88,325,000 88,063,000 87,283,000 21,664,750 86,784,000 86,694,000 86,497,000 20,981,750 85,856,000 85,518,000 80,349,000 18,512,500 75,948,000 75,879,000 70,260,000 16,717,000 67,199,000 66,799,000 66,600,000           54,836,000 46,618,000 199,000 39,096,000 39,046,000 38,669,000 50,000 38,446,000 38,421,000 38,330,000 53,000 37,990,000 37,969,000 37,908,000   37,764,000 37,355,000   36,647,000 36,598,000 93,000 36,427,000 36,368,000 35,527,000 32,342,603 32,053  30,789,000   30,433,000 30,384,000 
    The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.