7Baggers

Sage Therapeutics, Inc
(NASDAQ:SAGE) 

SAGE stock logo

Sage Therapeutics, Inc., a biopharmaceutical company, develops and commercializes medicines to treat central nervous system disorders. Its lead product candidate is ZULRESSO, an intravenous formulation of brexanolone for the treatment of postpartum depression (PPD) in adults. The company's product p...

Founded: 2010
Full Time Employees: 675
Sector: Healthcare
Industry: Biotechnology
Pharmaceuticals
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At a glance:
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Income Statements:
Quarterly
Annual
    Unit: USD2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 
                                                 
      product revenue
    		  442,000 843,000 600,000 1,690,000 1,985,000 2,716,000 2,460,000 3,294,000 2,865,000 1,739,000 1,501,000 1,582,000 1,642,000 1,440,000 1,643,000 1,583,000 1,686,000 1,639,000 1,089,000 2,286,000 1,960,000 1,478,000 519,000                     
      collaboration revenue - related party
    		23,209,000 13,827,000 11,426,000 11,028,000 7,420,000 6,212,000                                        
      other revenue
    		8,451,000 236,000                                            
      total revenues
    		31,660,000 14,063,000 12,816,000 11,871,000 8,654,000                                         
      yoy
    		265.84%                                             
      qoq
    		125.13% 9.73% 7.96% 37.17%                                          
      operating costs and expenses:
    		                                             
      cost of revenues
    		-55,000 655,000 1,489,000 5,278,000 1,407,000 1,269,000                                        
      research and development
    		23,917,000 22,759,000 37,022,000 54,576,000 62,564,000 71,734,000 64,330,000 101,919,000 97,161,000 92,826,000 89,295,000 81,553,000 77,297,000 78,018,000 75,443,000 83,497,000 66,170,000 58,056,000 81,706,000 74,078,000 73,320,000 63,610,000 91,250,000 102,108,000 89,059,000 86,398,000 88,805,000 75,052,000 68,980,000 49,270,000 50,891,000 58,286,000 55,900,000 45,200,000 42,004,000 29,075,000 26,096,000 23,581,000 20,376,000 17,478,000 18,603,000 12,900,000 8,945,000 6,601,000 4,381,000 
      selling, general and administrative
    		61,997,000 57,591,000 54,645,000 53,219,000 55,983,000 52,574,000 55,109,000 78,142,000 75,565,000 65,708,000 67,329,000 61,482,000 52,411,000 46,477,000 51,599,000 48,706,000 43,346,000 39,847,000 53,498,000 35,099,000 38,224,000 70,130,000 85,129,000 88,502,000 88,227,000                     
      restructuring
    		-230,000 513,000     -213,000 33,599,000           -130,000 -529,000 28,402,000                         
      total operating costs and expenses
    		85,629,000 81,518,000 115,010,000 113,073,000 119,954,000 125,577,000 120,046,000 214,565,000 172,931,000 158,764,000 156,767,000 143,219,000 129,908,000 124,781,000 127,129,000 132,334,000 109,664,000 98,090,000 135,210,000 108,797,000 140,056,000 133,910,000 176,598,000 190,747,000 177,330,000                     
      income from operations
    		-53,969,000 -67,455,000 -102,194,000 -101,202,000 -111,300,000 -117,675,000 -42,074,000 -211,849,000 -170,457,000 -155,470,000 -153,902,000 -141,480,000 -128,407,000 -123,199,000 -125,487,000 -130,894,000 -108,021,000 -96,507,000 973,976,000 -107,158,000 -138,967,000 -131,624,000 -174,638,000 -187,177,000 -176,457,000 -169,852,000 -164,227,000 -128,745,000 -22,147,000 -78,119,000 -70,449,000 -74,373,000 -70,854,000 -57,480,000 -56,378,000 -38,064,000 -35,006,000 -30,714,000 -28,612,000 -24,082,000 -25,059,000 -16,897,000 -12,361,000 -9,470,000 -6,188,000 
      yoy
    		-51.51% -42.68% 142.89% -52.23% -34.70% -24.31% -72.66% 49.74% 32.75% 26.19% 22.64% 8.09% 18.87% 27.66% -112.88% 22.15% -22.27% -26.68% -657.71% -42.75% -21.25% -22.51% 6.34% 45.39% 696.75% 117.43% 133.11% 73.11% -68.74% 35.91% 24.96% 95.39% 102.41% 87.15% 97.04% 58.06% 39.69% 81.77% 131.47% 154.30% 304.96%     
      qoq
    		-19.99% -33.99% 0.98% -9.07% -5.42% 179.69% -80.14% 24.28% 9.64% 1.02% 8.78% 10.18% 4.23% -1.82% -4.13% 21.17% 11.93% -109.91% -1008.92% -22.89% 5.58% -24.63% -6.70% 6.08% 3.89% 3.43% 27.56% 481.32% -71.65% 10.89% -5.28% 4.97% 23.27% 1.95% 48.11% 8.74% 13.97% 7.35% 18.81% -3.90% 48.30% 36.70% 30.53% 53.04%  
      operating margin %
    		-170.46% -479.66% -797.39% -852.51% -1286.11% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      interest income
    		4,323,000 5,223,000 6,398,000 7,642,000 8,431,000 9,204,000 9,467,000 10,274,000 10,173,000 8,830,000 6,793,000 4,127,000 2,102,000 1,168,000 751,000 692,000 732,000 708,000 834,000 1,347,000 2,686,000 4,729,000 5,915,000 7,227,000 8,220,000 6,442,000 5,851,000 5,817,000 5,137,000 3,529,000 1,043,000 677,000 672,000 707,000 494,000 275,000 266,000 175,000 63,000 53,000 41,000 21,000 4,000 3,000 1,000 
      other income
    		-6,000 18,000 18,000 9,000 15,000  -99,000 -55,000 -41,000  -37,000 30,000 45,000 -24,000 24,000 31,000 44,000 35,000 85,000 76,000 -66,000 155,000 70,000 -8,000 16,000 4,000 -12,000 10,000          -4,000 -13,000 -6,000 -9,000 5,000 -4,000 -1,000 -5,000 
      net income
    		-49,652,000 -62,214,000 -95,778,000 -93,551,000 -102,854,000 -108,483,000 -32,706,000 -201,630,000 -160,325,000 -146,828,000 -147,146,000 -137,323,000 -126,260,000 -122,055,000 -124,712,000 -130,171,000 -107,245,000 -95,764,000 974,895,000 -105,735,000 -136,347,000 -126,740,000 -168,653,000 -179,958,000 -168,221,000 -163,406,000 -158,388,000 -122,918,000 -16,978,000 -74,598,000 -69,422,000 -73,719,000 -70,202,000 -56,778,000 -55,901,000 -37,796,000 -34,747,000         
      yoy
    		-51.73% -42.65% 192.85% -53.60% -35.85% -26.12% -77.77% 46.83% 26.98% 20.30% 17.99% 5.49% 17.73% 27.45% -112.79% 23.11% -21.34% -24.44% -678.05% -41.24% -18.95% -22.44% 6.48% 46.40% 890.82% 119.05% 128.15% 66.74% -75.82% 31.39% 24.19% 95.04% 102.04%             
      qoq
    		-20.19% -35.04% 2.38% -9.04% -5.19% 231.69% -83.78% 25.76% 9.19% -0.22% 7.15% 8.76% 3.45% -2.13% -4.19% 21.38% 11.99% -109.82% -1022.02% -22.45% 7.58% -24.85% -6.28% 6.98% 2.95% 3.17% 28.86% 623.98% -77.24% 7.46% -5.83% 5.01% 23.64% 1.57% 47.90% 8.77%          
      net income margin %
    		-156.83% -442.39% -747.33% -788.06% -1188.51% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% 
      net income per share
    		-0.79 -1.01 -1.56 -1.53 -1.7 -1.8 -0.54 -3.37 -2.68 -2.46 -2.47 -2.31 -2.13 -2.07 -2.11 -2.21 -1.83 -1.64 18.76 -2.03 -2.63 -2.44 -3.25 -3.48 -3.28 -3.37 -3.4 -2.63 -0.36 -1.68 -1.72 -1.97 -1.88 -1.52 -1.55 -1.15 -1.08 -0.97 -1 -0.84 -0.9 -0.66 1.41 -0.5 -4.57 
      weighted-average number of common shares outstanding—basic and diluted
    		62,610,598 61,857,573 60,765,913 61,116,524 60,538,319 60,136,198 59,836,441 59,912,378 59,769,640 59,674,127  59,428,123 59,266,322 59,028,858  58,819,548 58,582,569 58,374,219  51,981,468 51,926,074 51,908,760 50,833,837 51,704,687 51,257,640 48,491,834 46,121,194 46,706,770 46,541,716 44,325,371 38,113,678               
      comprehensive loss:
    		                                             
      other comprehensive items:
    		                                             
      unrealized gain on marketable securities
    		-127 -102 -657 1,592 96 27 2,921 1,909 -556 5,118       -49 -651 -531 -763 2,501 -2,087 -482 202 1,681 409 -258 -112 40 -156 -14 52 14 21   39         
      total comprehensive loss
    		-49,779 -62,316 -96,435 -91,959 -102,758 -108,456 -29,785 -199,721 -160,881 -141,710 -99,465.25 -138,334 -128,931 -130,596 -83,475.25 -130,192 -107,294 -96,415 -92,292.75 -106,498 -133,846 -128,827 -169,135 -179,756 -166,540 -162,997 -158,646 -123,030 -16,938 -74,754 -69,436 -73,667 -70,188 -56,757 -55,968 -37,870 -34,708         
      includes related-party amounts of 372 and 609 for the three and six months ended june 30, 2025, respectively (see note 7).
    		                                             
      consists of related-party amounts of 0.2m for the quarter ended march 31, 2025 (see note 7).
    		                                             
      other collaboration revenue
    		  948,000  634,000                                         
      total revenue
    		     7,902,000 77,972,000 2,716,000 2,474,000          1,109,186,000 1,639,000 1,089,000 2,286,000 1,960,000 3,570,000 873,000                     
      other expense
    		     -12,000    -188,000                   32,000 -8,000 -16,000 -23,000 -20,000 -5,000 -17,000 -7,000 -7,000         
      collaboration revenue
    		      3,500  14,000               2,092,000 354,000 465,000 273,000  90,000,000                 
      cost of goods sold
    		      334,750 905,000 205,000 230,000 143,000 184,000 200,000 286,000 87,000 131,000 148,000 187,000 136,000 149,000 110,000 170,000 219,000 137,000 44,000                     
      total other comprehensive gain
    		      1,617.75 1,909 -556 5,118       -49 -651 -531 -763 2,501 -2,087 -482 202 1,681 409 -258 -112 40 -156 -14 52 14 21   39         
      unrealized loss on marketable securities
    		          4,677 -1,011 -2,671 -8,541 -180.25 -21                   -67 -74          
      total other comprehensive loss
    		          4,677 -1,011 -2,671 -8,541 -180.25 -21                   -67 -74          
      operating expenses:
    		                                             
      general and administrative
    		                         83,919,000 75,695,000 53,693,000 43,167,000 28,849,000 19,558,000 16,087,000 14,954,000 12,280,000 14,374,000 8,989,000 8,910,000 7,133,000 8,236,000 6,604,000 6,456,000 3,997,000 3,416,000 2,869,000 1,807,000 
      total operating expenses
    		                         170,317,000 164,500,000 128,745,000 112,147,000 78,119,000 70,449,000 74,373,000 70,854,000 57,480,000 56,378,000 38,064,000 35,006,000 30,714,000 28,612,000 24,082,000 25,059,000 16,897,000 12,361,000 9,470,000 6,188,000 
      weighted-average common shares outstanding—basic and diluted
    		                               37,470,912 37,361,129 37,269,148  32,975,897          
      weighted-average shares outstanding—basic and diluted
    		                                    32,062,298         
      net loss and comprehensive loss
    		                                     -30,543,000        
      weighted-average number of common shares used in net loss per share—basic and diluted
    		                                     31,643,216        
      net income and comprehensive loss
    		                                      -28,562,000 -24,035,000 -25,027,000 -16,871,000 -12,361,000 -9,468,000 -6,192,000 
      accretion of redeemable convertible preferred stock to redemption value
    		                                           -391,000 -1,577,000 
      net income attributable to common stockholders
    		                                      -28,562,000 -24,035,000 -25,027,000 -16,871,000 -12,361,000 -9,859,000 -7,769,000 
      weighted-average number of common shares used in net income per share attributable to common stockholders—basic and diluted
    		                                      27,778,288 28,737,743 27,860,332 25,655,883 21,574,347 19,581,624 1,700,517 
                                                 
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 
                                                   
        assets
      		                                             
        current assets:
      		                                             
        cash and cash equivalents
      		67,487,000 45,224,000 81,021,000 99,627,000 99,901,000 172,653,000 70,992,000 148,712,000 121,416,000 206,557,000 162,700,000 199,826,000 206,510,000 178,674,000 294,233,000 422,165,000 514,158,000 899,250,000 1,661,082,000 184,270,000 258,228,000 199,444,000 126,705,000 259,181,000 166,185,000 342,295,000 190,943,000 253,123,000 325,830,000 557,555,000 306,235,000 134,916,000 133,450,000 145,460,000 168,517,000 320,078,000 189,003,000 299,680,000 186,753,000 204,877,000 224,234,000 113,162,000 127,766,000 136,727,000 49,127,000 
        marketable securities
      		298,085,000 378,630,000 423,397,000 469,527,000 546,892,000 544,360,000 682,192,000 727,340,000 881,200,000 923,028,000 1,109,794,000 1,193,813,000 1,307,197,000 1,446,567,000 1,448,063,000 1,421,004,000 1,397,157,000 1,104,767,000 438,467,000 484,267,000 498,294,000 673,313,000 881,688,000 863,069,000 1,070,364,000 1,008,956,000 731,833,000 768,278,000 766,603,000 525,958,000 212,613,000 108,535,000 152,478,000 197,104,000 228,962,000 111,192,000 83,292,000         
        collaboration receivable - related party
      		16,270,000 10,729,000 9,134,000 14,871,000 9,943,000 10,509,000 83,009,000 22,513,000 15,090,000 15,002,000 13,660,000 18,448,000 23,722,000 19,797,000 18,506,000 24,185,000 48,438,000 24,766,000                            
        other receivable
      		8,105,000                                             
        prepaid expenses and other current assets
      		19,138,000 19,893,000 17,749,000 19,630,000 28,743,000 26,588,000 31,825,000 34,705,000 46,321,000 58,850,000 50,826,000 53,017,000 41,455,000 37,206,000 39,841,000 34,343,000 28,846,000 23,083,000 22,821,000 30,347,000 28,862,000 25,479,000 26,700,000 30,413,000 27,021,000 20,281,000 21,919,000 18,511,000 12,958,000 11,575,000 6,227,000 4,892,000 5,192,000 6,480,000 5,100,000 3,418,000 1,812,000 2,926,000 1,738,000 2,604,000 3,274,000 1,367,000 1,056,000 1,063,000 2,416,000 
        total current assets
      		409,085,000 454,476,000 531,301,000 604,987,000 686,811,000 755,442,000 869,350,000 933,270,000 1,064,027,000 1,203,437,000 1,336,980,000 1,465,104,000 1,578,884,000 1,682,244,000 1,800,643,000 1,901,697,000 1,988,599,000 2,051,866,000 2,122,370,000 698,884,000 785,384,000 898,236,000 1,035,093,000 1,152,663,000 1,263,570,000 1,371,532,000 944,695,000 1,039,912,000 1,123,769,000 1,095,088,000 525,075,000 248,343,000 291,120,000 349,044,000 402,579,000 434,688,000 274,107,000 302,606,000 188,491,000 207,481,000 227,508,000 114,529,000 128,822,000 137,790,000 51,543,000 
        property and equipment
      		674,000 778,000 890,000 1,019,000 1,274,000 1,585,000 1,921,000 2,442,000 2,480,000 2,663,000 2,898,000 2,821,000 2,938,000 2,840,000 3,016,000 2,907,000 3,280,000 4,173,000 6,755,000 7,404,000 8,077,000 8,684,000 9,126,000 9,365,000 8,363,000 6,513,000 5,643,000 5,168,000 4,445,000 4,295,000 4,013,000 1,893,000 1,443,000 1,560,000 1,388,000 1,049,000 959,000 865,000 286,000 249,000 285,000 269,000 163,000 134,000 69,000 
        restricted cash
      		1,450,000 1,450,000  1,332,000 1,332,000 1,332,000 1,332,000 1,332,000 1,332,000 1,269,000 1,269,000 1,269,000 1,269,000 1,269,000 1,269,000 1,269,000 1,269,000 1,269,000 1,716,000 2,367,000 2,367,000 2,367,000 2,367,000 2,367,000 2,367,000 2,367,000 2,367,000 1,919,000 1,269,000 1,269,000 849,000 849,000 849,000 564,000 564,000 564,000 564,000 39,000 39,000 39,000 39,000 39,000 39,000 39,000 39,000 
        right-of-use operating asset
      		9,957,000 10,357,000 10,753,000 11,251,000 1,220,000 2,857,000 4,458,000 6,026,000 7,560,000 9,062,000 10,532,000 11,970,000 13,379,000 14,759,000 16,109,000 17,432,000 18,728,000 19,998,000 25,064,000 26,546,000 27,999,000 31,992,000 33,771,000 35,514,000                      
        other long-term assets
      		1,756,000 2,608,000 2,828,000 5,175,000 7,800,000 6,216,000 6,548,000 6,593,000 6,889,000 4,255,000 4,770,000 4,909,000 4,907,000 4,591,000 4,251,000 3,875,000 3,599,000 3,392,000 3,341,000 3,427,000 3,415,000 3,694,000 3,793,000 3,818,000 4,023,000 4,378,000                    
        total assets
      		422,922,000 469,669,000 547,222,000 622,432,000 697,105,000 767,600,000 882,277,000 949,663,000 1,082,288,000 1,220,686,000 1,356,449,000 1,486,073,000 1,601,377,000 1,705,703,000 1,825,288,000 1,927,180,000 2,015,475,000 2,080,698,000 2,159,246,000 738,628,000 827,242,000 944,973,000 1,084,150,000 1,203,727,000 1,315,547,000 1,422,914,000 952,705,000 1,046,999,000 1,129,483,000 1,100,652,000 529,937,000 251,085,000 293,412,000 351,168,000 404,531,000 436,301,000 275,630,000 303,510,000 189,016,000 208,410,000 228,473,000 115,478,000 129,665,000 137,963,000 51,651,000 
        liabilities and stockholders’ equity
      		                                             
        current liabilities:
      		                                             
        accounts payable
      		692,000 5,435,000 12,699,000 7,126,000 8,650,000 6,479,000 10,318,000 11,136,000 9,283,000 12,263,000 18,950,000 7,077,000 5,410,000 7,129,000 10,450,000 4,733,000 2,917,000 3,285,000 3,691,000 4,289,000 2,387,000 7,910,000 15,266,000 5,041,000 12,431,000 13,556,000 34,036,000 5,879,000 8,338,000 8,350,000 9,350,000 13,030,000 6,042,000 8,230,000 12,817,000 5,237,000 5,957,000 4,540,000 5,159,000 3,246,000 5,195,000 2,782,000 2,429,000 2,157,000 1,862,000 
        accrued expenses
      		42,072,000 42,531,000 57,598,000 53,197,000 58,982,000 52,014,000 67,264,000 114,901,000 79,799,000 64,745,000 72,666,000 85,007,000 76,268,000 63,051,000 67,275,000 66,795,000 61,623,000 51,420,000 54,851,000 46,756,000 53,328,000 52,180,000 86,618,000 78,127,000 58,912,000 47,651,000 51,994,000 48,647,000 39,581,000 29,522,000 42,601,000 36,807,000 26,239,000 23,652,000 22,352,000 17,093,000 12,382,000 11,430,000 10,148,000 6,404,000 5,164,000 5,522,000 4,687,000 2,853,000 2,069,000 
        operating lease liability, current portion
      		1,878,000 1,812,000 1,318,000 83,000 1,411,000 3,306,000 5,165,000 6,967,000 7,725,000 7,684,000 7,643,000 7,603,000 7,563,000 7,523,000 7,468,000 7,414,000 7,358,000 7,306,000 8,662,000 8,620,000 8,577,000 10,270,000 10,244,000                       
        total current liabilities
      		44,642,000 49,778,000 71,615,000 60,406,000 69,043,000 61,799,000 82,747,000 133,004,000 96,807,000 84,692,000 99,259,000 99,687,000 89,241,000 77,703,000 85,193,000 78,942,000 71,898,000 62,011,000 67,204,000 59,665,000 64,292,000 70,360,000 112,128,000 90,956,000 78,953,000 68,376,000 86,030,000 54,526,000 47,919,000 37,872,000 51,951,000 49,837,000 32,281,000 31,882,000 35,169,000 22,330,000 18,339,000 15,970,000 15,307,000 10,291,000 11,000,000 8,945,000 7,757,000 5,010,000 3,931,000 
        operating lease liability, net of current portion
      		9,543,000 10,043,000 10,518,000 10,191,000     1,003,000 2,763,000 4,491,000 6,164,000 7,800,000 9,396,000 10,964,000 12,481,000 13,964,000 15,411,000 19,438,000 21,069,000 22,661,000 24,951,000 26,848,000                       
        total liabilities
      		54,185,000 59,821,000 82,133,000 70,597,000 69,043,000 61,799,000 82,747,000 133,004,000 97,912,000 87,557,000 103,850,000 105,951,000 97,141,000 87,201,000 96,257,000 91,526,000 85,963,000 77,422,000 86,912,000 81,047,000 87,327,000 95,767,000 139,495,000 122,656,000 112,672,000 103,380,000 89,734,000 58,494,000 51,720,000 41,376,000 54,462,000 51,033,000 33,108,000 32,722,000 36,014,000 22,564,000 18,421,000 16,010,000 15,321,000 10,306,000 11,022,000 8,968,000 7,780,000 5,044,000 3,971,000 
        commitments and contingencies
      		                                             
        stockholders’ equity:
      		                                             
        preferred stock, 0.0001 par value per share...
      		                                             
        common stock, 0.0001 par value per share...
      		6,000 6,000 6,000 6,000 6,000 6,000 6,000 6,000 6,000 6,000 6,000 6,000 6,000 6,000 6,000 6,000 6,000 6,000 6,000 5,000 5,000 5,000 5,000 5,000 5,000 5,000 5,000 5,000 5,000 5,000 5,000 4,000 4,000 4,000 4,000 4,000 3,000         
        treasury stock
      		-400,000 -400,000 -400,000 -400,000 -400,000 -400,000 -400,000 -400,000 -400,000 -400,000 -400,000 -400,000 -400,000 -400,000 -400,000 -400,000 -400,000 -400,000 -400,000 -400,000 -400,000 -400,000 -400,000 -400,000 -400,000 -400,000 -211,000 -211,000 -211,000 -211,000 -113,000 -17,000 -17,000 -17,000 -17,000           
        additional paid-in capital
      		3,451,307,000 3,442,639,000 3,435,564,000 3,425,875,000 3,410,143,000 3,385,124,000 3,370,397,000 3,357,741,000 3,325,737,000 3,313,609,000 3,291,369,000 3,276,423,000 3,262,203,000 3,247,538,000 3,227,471,000 3,207,028,000 3,170,694,000 3,137,164,000 3,109,807,000 2,669,419,000 2,645,255,000 2,620,700,000 2,587,322,000 2,554,603,000 2,496,651,000 2,446,770,000 1,827,021,000 1,793,909,000 1,760,137,000 1,724,712,000 1,066,059,000 721,105,000 707,690,000 695,645,000 688,959,000 678,194,000 483,797,000 479,380,000 335,032,000 330,879,000 326,191,000 190,223,000 188,727,000 187,400,000  
        accumulated deficit
      		-3,082,191,000 -3,032,539,000 -2,970,325,000 -2,874,547,000 -2,780,996,000 -2,678,142,000 -2,569,659,000 -2,536,953,000 -2,335,323,000 -2,174,998,000 -2,028,170,000 -1,881,024,000 -1,743,701,000 -1,617,441,000 -1,495,386,000 -1,370,674,000 -1,240,503,000 -1,133,258,000 -1,037,494,000 -2,012,389,000 -1,906,654,000 -1,770,307,000 -1,643,567,000 -1,474,914,000 -1,294,956,000 -1,126,735,000 -963,329,000 -804,941,000 -682,023,000 -665,045,000 -590,447,000 -521,025,000 -447,306,000 -377,105,000 -320,327,000 -264,426,000 -226,630,000 -191,883,000 -161,340,000 -132,778,000 -108,743,000 -83,716,000 -66,845,000 -54,484,000 -44,792,000 
        accumulated other comprehensive income
      		15,000 142,000 244,000                               -81,000 -102,000           
        total stockholders’ equity
      		368,737,000 409,848,000 465,089,000 551,835,000 628,062,000 705,801,000 799,530,000 816,659,000 984,376,000 1,133,129,000 1,252,599,000 1,380,122,000 1,504,236,000 1,618,502,000 1,729,031,000 1,835,654,000 1,929,512,000 2,003,276,000 2,072,334,000 657,581,000 739,915,000 849,206,000 944,655,000 1,081,071,000 1,202,875,000 1,319,534,000 862,971,000 988,505,000 1,077,763,000 1,059,276,000 475,475,000 200,052,000 260,304,000 318,446,000 368,517,000 413,737,000 257,209,000 287,500,000 173,695,000 198,104,000 217,451,000 106,510,000 121,885,000 132,919,000  
        total liabilities and stockholders’ equity
      		422,922,000 469,669,000 547,222,000 622,432,000 697,105,000 767,600,000 882,277,000 949,663,000 1,082,288,000 1,220,686,000 1,356,449,000 1,486,073,000 1,601,377,000 1,705,703,000 1,825,288,000 1,927,180,000 2,015,475,000 2,080,698,000 2,159,246,000 738,628,000 827,242,000 944,973,000 1,084,150,000 1,203,727,000 1,315,547,000 1,422,914,000 952,705,000 1,046,999,000 1,129,483,000 1,100,652,000 529,937,000 251,085,000 293,412,000 351,168,000 404,531,000 436,301,000 275,630,000 303,510,000 189,016,000 208,410,000 228,473,000 115,478,000    
        accumulated other comprehensive gain
      		   901,000           -2,660,000 -306,000 -285,000 -236,000 415,000 946,000 1,709,000 -792,000 1,295,000 1,777,000 1,575,000                     
        accumulated other comprehensive loss
      		    -691,000 -787,000 -814,000 -3,735,000 -5,644,000 -5,088,000 -10,206,000 -14,883,000 -13,872,000 -11,201,000            -106,000 -515,000 -257,000 -145,000 -185,000 -29,000 -15,000 -67,000             
        other liabilities
      		        102,000 102,000 100,000 100,000 100,000 102,000 100,000 103,000 101,000  270,000 313,000 374,000 456,000 519,000    3,704,000 3,968,000 3,801,000 3,504,000 2,511,000 1,196,000 827,000 840,000 845,000 234,000 82,000 40,000 14,000 15,000 22,000 23,000 23,000   
        other current liabilities
      		                       7,788,000 7,610,000 7,169,000                    
        long-term lease operating liability, net of current portion
      		                       31,360,000 33,309,000 34,528,000                    
        other long-term liabilities
      		                       340,000 410,000 476,000                    
        right of use operating asset
      		                        37,224,000 38,124,000                    
        receivable from collaborator
      		                            18,378,000                 
        deferred offering costs
      		                                      200,000       
        accumulated other comprehensive items
      		                                   -35,000 39,000         
        preferred stock, 0.0001 par value...
      		                                             
        common stock, 0.0001 par value...
      		                                     3,000 3,000 3,000 3,000 3,000 3,000 3,000  
        deferred tax assets
      		                                       641,000 641,000 641,000 641,000   
        deferred tax liabilities
      		                                       641,000 641,000 641,000 641,000   
        liabilities, redeemable convertible preferred stock and stockholders’ equity
      		                                             
        redeemable convertible preferred stock (series a, b and c), 0.0001 par value...
      		                                            92,472,000 
        stockholders’ equity
      		                                             
        total liabilities, redeemable convertible preferred stock and stockholders’ equity
      		                                          129,665,000 137,963,000  
        other liabilities:
      		                                           34,000 40,000 
        liabilities, redeemable convertible preferred stock and stockholders’ deficit
      		                                             
        stockholders’ deficit:
      		                                             
        total stockholders’ deficit
      		                                            -44,792,000 
        total liabilities, redeemable convertible preferred stock and stockholders’ deficit
      		                                            51,651,000 
        operating expenses:
      		                                             
        research and development
      		                                            4,381,000 
        general and administrative
      		                                            1,807,000 
        total operating expenses
      		                                            6,188,000 
        income from operations
      		                                            -6,188,000 
        interest income
      		                                            1,000 
        other income
      		                                            -5,000 
        net income and comprehensive loss
      		                                            -6,192,000 
        accretion of redeemable convertible preferred stock to redemption value
      		                                            -1,577,000 
        net income attributable to common stockholders
      		                                            -7,769,000 
        net income per share
      		                                            -4,570 
        weighted-average number of common shares used in net income per share attributable to common stockholders—basic and diluted
      		                                            1,700,517,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 
                                                    
          cash flows from operating activities
        		                                            
          net loss
        		-49,652,000 -62,214,000 -95,778,000 -93,551,000 -102,854,000 -108,483,000 -32,706,000 -201,630,000 -160,325,000 -146,828,000  -137,323,000 -126,260,000 -122,055,000  -130,171,000 -107,245,000 -95,764,000  -105,735,000 -136,347,000 -126,740,000 -168,653,000 -179,958,000 -168,221,000 -163,406,000 -158,388,000 -122,918,000 -16,978,000 -74,598,000 -69,422,000 -73,719,000 -70,201,000 -56,778,000 -55,901,000 -37,796,000 -34,747,000 -30,543,000       
          adjustments to reconcile net loss to net cash from operating activities:
        		                                            
          stock-based compensation expense
        		8,733,000 6,927,000 9,432,000 14,207,000 17,167,000 13,698,000 12,945,000 28,691,000 11,693,000 20,038,000 15,244,000 13,169,000 14,636,000 18,553,000 20,648,000 34,342,000 27,663,000 21,976,000 20,744,000 20,108,000 24,032,000 31,110,000 30,679,000 43,669,000 34,767,000 44,116,000 31,640,000 25,478,000 29,028,000 15,817,000 10,245,000 9,731,000 9,350,000 6,208,000 10,093,000 4,748,000 4,465,000 3,714,000 4,086,000 4,407,000 5,398,000 1,349,000 1,326,000 691,000 
          premium on marketable securities
        		-158,000 -137,000 -158,000 -51,000 -112,000 -23,000 -61,000 0 -42,000 -29,000 -36,000 -10,000 -265,000 -1,189,000 -3,849,000 -2,919,000 -7,414,000 -9,459,000 -670,000 -572,000 -254,000 -240,000 -1,022,000 -765,000 -1,148,000 -739,000 -50,000 -90,000 -71,000 -4,000 -56,000    -93,000 -394,000         
          amortization of discount on marketable securities
        		-442,000 -981,000  -2,047,000 -1,937,000 -1,554,000                -18,000 -537,000 -1,456,000 -2,651,000 -2,322,000                   
          depreciation expense
        		104,000 112,000 129,000 255,000 311,000 336,000 409,000 330,000 331,000 323,000 290,000 278,000                                 
          changes in operating assets and liabilities:
        		                                            
          collaboration receivable - related party
        		-5,541,000 -1,595,000 5,737,000 -4,928,000 566,000 72,500,000 -60,496,000 -7,423,000 -88,000 -1,342,000 4,788,000 5,274,000 -3,925,000 -1,291,000 5,679,000 24,253,000 -23,672,000 -24,766,000                           
          other receivable
        		                                            
          prepaid expenses and other current assets
        		755,000 -2,144,000 1,881,000 9,113,000 -2,155,000 5,237,000 2,880,000 11,616,000 12,529,000 -8,024,000 2,191,000 -11,562,000 -4,249,000 2,635,000 -5,498,000 -5,497,000 -5,763,000 -262,000 7,526,000 -1,485,000 -3,383,000 1,221,000 3,713,000 -3,392,000 -6,739,000 1,637,000 -3,191,000 12,820,000 -19,743,000 -5,348,000 -1,335,000 301,000 1,287,000 -1,380,000 -1,682,000 -1,606,000 1,115,000 -1,189,000 867,000 671,000 -2,085,000 -134,000 7,000 -287,000 
          other long-term assets
        		852,000 220,000 847,000 2,625,000 -84,000 332,000 45,000 296,000 -2,634,000 515,000 139,000 -2,000 -316,000 -340,000 -376,000 -276,000 -207,000 -51,000 86,000 -12,000 279,000 99,000 25,000 205,000 -2,645,000 -1,378,000                   
          right-of-use operating asset
        		400,000 396,000 623,000 1,441,000 1,637,000 1,601,000 1,568,000 1,534,000 1,502,000 1,470,000 1,438,000 1,409,000 1,380,000 1,350,000 1,323,000 1,296,000 1,269,000 1,333,000 1,483,000 1,453,000 1,683,000 1,778,000 1,744,000                      
          operating lease liabilities, current
        		66,000 494,000 1,235,000 -1,328,000 -1,895,000 -1,859,000 -1,802,000 -758,000 41,000 41,000 40,000 40,000 40,000 55,000 54,000 55,000 53,000 44,000 42,000 43,000 -74,000 25,000                       
          operating lease liabilities, non-current
        		-500,000 -475,000 -1,228,000    0 -1,003,000 -1,760,000 -1,728,000 -1,673,000 -1,636,000 -1,596,000 -1,568,000 -1,517,000 -1,482,000 -1,447,000 -1,498,000 -1,631,000 -1,592,000 -1,705,000 -1,897,000                       
          accounts payable
        		-4,743,000 -7,264,000 5,573,000 -1,524,000 2,171,000 -3,839,000 -818,000 1,889,000 -3,016,000 -6,550,000 11,790,000 1,868,000 -1,974,000 -3,251,000 5,647,000 1,816,000 -368,000 -406,000 -598,000 1,902,000 -5,508,000 -7,307,000 10,172,000 -7,149,000 -1,299,000 -20,507,000 27,914,000 -2,467,000 -26,000 -877,000 -3,914,000 6,989,000 -2,125,000 -4,643,000 7,680,000 -825,000 1,740,000 -799,000 1,882,000 -1,952,000 2,417,000 343,000 447,000 379,000 
          accrued expenses and other liabilities
        		-459,000 -15,067,000 6,090,000 -6,726,000 6,748,000 -15,778,000 -47,664,000 35,543,000 14,642,000 -8,389,000 -12,668,000 8,562,000 13,230,000 -4,507,000 443,000 5,349,000 10,106,000 -4,140,000 8,025,000 -6,100,000 1,309,000 -35,391,000 8,312,000 19,522,000 14,162,000 -8,192,000 2,925,000 9,450,000 10,215,000 -12,460,000 5,684,000 10,581,000 2,511,000 1,220,000 5,846,000 4,920,000 937,000 1,341,000 3,743,000      
          net cash from operating activities
        		-58,690,000 -81,728,000 -66,560,000 -82,365,000 -80,437,000 -37,832,000 -119,519,000 -135,866,000 -131,518,000 -153,682,000 -126,932,000 -118,865,000 -106,439,000 -107,800,000 -97,501,000 -68,826,000 -102,769,000 -109,086,000 1,010,971,000 -91,016,000 -118,984,000 -136,691,000 -116,726,000 -128,702,000 -133,344,000 -149,934,000 -101,778,000 -80,187,000 -135,000 -78,571,000 -58,899,000 -46,092,000 -59,076,000 -55,210,000 -33,776,000 -30,796,000 -26,671,000 -27,435,000 -18,117,000 -19,515,000 -18,443,000 -14,606,000 -8,667,000 -7,486,000 
          capital expenditures
        		0 0 0 0 0  112,000 -328,000 -112,000 -225,000 -199,000 -566,000 -122,000 -169,000 0 0 0  0 1,000 -70,000 -261,000 -319,000 -2,181,000 -2,007,000 -1,179,000 -776,000 -989,000 -407,000 -637,000 508,000 -235,000 -76,000 -181,000 -520,000 -66,000 0 -62,000 -38,000 21,000 -71,000 -110,000 -45,000 -78,000 
          free cash flows
        		-58,690,000 -81,728,000 -66,560,000 -82,365,000 -80,437,000  -119,407,000 -136,194,000 -131,630,000 -153,907,000 -127,131,000 -119,431,000 -106,561,000 -107,969,000 -97,501,000 -68,826,000 -102,769,000  1,010,971,000 -91,015,000 -119,054,000 -136,952,000 -117,045,000 -130,883,000 -135,351,000 -151,113,000 -102,554,000 -81,176,000 -542,000 -79,208,000 -58,391,000 -46,327,000 -59,152,000 -55,391,000 -34,296,000 -30,862,000 -26,671,000 -27,497,000 -18,155,000 -19,494,000 -18,514,000 -14,716,000 -8,712,000 -7,564,000 
          cash flows from investing activities
        		                                            
          proceeds from sales and maturities of marketable securities
        		149,620,000 133,756,000 135,278,000 183,371,000 197,932,000 201,054,000 176,905,000 230,779,000 278,470,000 351,982,000 288,591,000 362,716,000 263,561,000 292,539,000 288,863,000 338,273,000 177,969,000 182,970,000 135,410,000 170,570,000 320,572,000 275,197,000 213,430,000 369,188,000 281,389,000 307,263,000 250,625,000 460,672,000 181,500,000 81,960,000 46,789,000 104,000,000 59,683,000 50,753,000           
          purchases of marketable securities
        		-68,602,000 -87,973,000 -88,704,000 -102,317,000 -198,318,000 -61,618,000 -134,956,000 -70,059,000 -232,765,000 -156,890,000 -198,532,000 -251,400,000 -129,177,000 -301,928,000 -318,752,000 -363,256,000 -466,357,000 -841,786,000 -89,891,000 -157,058,000 -143,120,000 -68,651,000 -230,973,000 -159,469,000 -337,317,000 -580,916,000 -211,399,000 -459,622,000 -419,228,000 -394,109,000 -150,587,000 -59,894,000 -15,014,000 -18,908,000 -140,443,000 -35,653,000         
          net cash from investing activities
        		81,018,000 45,783,000 46,574,000 81,054,000 -386,000 139,436,000 42,061,000 160,392,000 45,593,000 194,867,000 89,777,000 110,952,000 134,262,000 -9,558,000 -30,261,000 -24,983,000 -288,388,000 -658,816,000 45,519,000 13,513,000 177,382,000 206,270,000 -17,916,000 207,779,000 -58,109,000 -274,910,000 38,418,000 52,000 -238,130,000 -312,801,000 -104,602,000 43,871,000 44,308,000 31,600,000 -118,463,000 -27,720,000 -84,016,000 -341,000 -38,000 21,000 -71,000 -110,000 -45,000 -78,000 
          cash flows from financing activities
        		                                            
          proceeds from stock option exercises and employee stock purchase plan issuances
        		0 242,000 -1,000 1,435,000 26,000 1,559,000 0 2,774,000 855,000 3,301,000 33,000 1,244,000 37,000 1,799,000 419,000 1,816,000 6,861,000 5,623,000 2,171,000 3,545,000 386,000 3,160,000 2,166,000 15,402,000 15,601,000 15,681,000 1,628,000 8,078,000 6,645,000 12,757,000 8,974,000 3,687,000 2,758,000 553,000 678,000 416,000 10,000 302,000       
          payments of offering costs
        		  0 0                   0 0 -258,000 -70,000 0 0 -105,000 -235,000     0 0         
          proceeds from public offerings of common stock, net of commissions and underwriting discounts
        		  0 1,000                   0 0 0 561,277,000 0 0 0 631,494,000     0 189,175,000         
          payment of employee tax obligations related to vesting of restricted stock units
        		-65,000 -94,000 -1,000 -399,000 -1,000 -2,000 -262,000 -4,000 -8,000 -629,000 -4,000 -15,000   -589,000 0       0 -1,483,000 0 -692,000 0 0 0 -904,000               
          net cash from financing activities
        		-65,000 148,000 -2,000 1,037,000 8,071,000 1,557,000 -262,000 2,770,000 847,000 2,672,000 29,000 1,229,000 13,000 1,799,000 -170,000 1,816,000 6,065,000 5,623,000 419,671,000 3,545,000 386,000 3,160,000 2,166,000 13,919,000 15,343,000 576,196,000 1,628,000 8,078,000 6,540,000 643,112,000 334,820,000 3,687,000 2,758,000 553,000 678,000 189,591,000 10,000 140,703,000 31,000 137,000 129,586,000 112,000 -249,000 95,164,000 
          net increase in cash, cash equivalents and restricted cash
        		22,263,000 -35,797,000 -19,988,000 -274,000 -72,752,000 103,161,000    43,857,000     -127,932,000 -91,993,000 -385,092,000 -762,279,000 1,476,161,000 -73,958,000 58,784,000 72,739,000 -132,476,000 92,996,000 -176,110,000 151,352,000   -231,725,000 251,740,000               
          cash, cash equivalents, and restricted cash at beginning of period
        		0 82,471,000                                           
          cash, cash equivalents, and restricted cash at end of period
        		22,263,000 46,674,000                                           
          reconciliation of cash, cash equivalents, and restricted cash reported in the consolidated balance sheets
        		                                            
          cash and cash equivalents
        		22,263,000 45,224,000                                           
          restricted cash
        		0 1,450,000                                           
          total cash, cash equivalents, and restricted cash shown in the statement of cash flows
        		22,263,000 46,674,000                                           
          adjustments to reconcile net loss to net cash used in operating activities:
        		                                            
          amortization of (discount) premium on marketable securities
        		                                            
          purchases of property and equipment
        		      112,000 -328,000 -112,000 -225,000 -282,000 -364,000 -122,000 -169,000     0 1,000 -70,000 -276,000 -373,000 -1,940,000 -2,181,000 -1,257,000 -808,000 -998,000 -402,000 -652,000 -804,000 -235,000 -76,000 -245,000 -520,000 -66,000         
          supplemental disclosure of non-cash operating activities
        		                                            
          right-of-use assets obtained in exchange for new operating lease liabilities
        		  125,000                    0                      
          purchases of property and equipment included in accounts payable
        		          83,000 -202,000          15,000 54,000 -241,000 174,000 78,000 32,000 9,000 -5,000 15,000               
          cash, cash equivalents and restricted cash at beginning of period
        		   0 0 72,324,000 0 0 0 163,969,000 0 0 0 295,502,000 0 0 0 1,662,798,000 0 0 0 129,072,000 0 0 0 193,310,000 0 0 0 307,084,000               
          cash, cash equivalents and restricted cash at end of period
        		   -274,000 -72,752,000 175,485,000 -77,720,000 27,296,000 -85,078,000 207,826,000 -37,126,000 -6,684,000 27,836,000 179,943,000 -127,932,000 -91,993,000 -385,092,000 900,519,000 1,476,161,000 -73,958,000 58,784,000 201,811,000 -132,476,000 92,996,000 -176,110,000 344,662,000 -61,732,000 -72,057,000 -231,725,000 558,824,000               
          amortization of premium (discount) on marketable securities
        		      6,181,000 -4,951,000 -4,391,000 -3,179,000        1,325,000 420,000 324,000         -2,806,000 -1,348,000               
          net decrease in cash, cash equivalents and restricted cash
        		      -77,720,000 27,296,000    -6,684,000 27,836,000 -115,559,000                               
          lease asset de-recognized upon lease cancellation
        		              0 0 0 3,733,000 0 0                         
          adjustments to reconcile net loss to net cash (used in) operating activities:
        		                                            
          net income
        		                                      -28,562,000 -24,035,000 -25,027,000 -16,871,000 -12,361,000 -9,468,000 
          adjustments to reconcile net income to net cash from (used in) operating activities:
        		                                            
          amortization of premium on marketable securities
        		          -1,329,000 1,068,000 2,581,000 3,533,000  4,034,000                -62,000 -28,000 33,000 199,000 74,000         
          proceeds from the sale of common stock under the stock purchase agreement - related party
        		                                            
          supplemental disclosure of non-cash operating and investing activities
        		                                            
          depreciation
        		             275,000 333,000 374,000 893,000 2,582,000 649,000 650,000 662,000 669,000 665,000 698,000 505,000 415,000 363,000 287,000 246,000 247,000 135,000 136,000 130,000 130,000 82,000 83,000 75,000 41,000 32,000      
          adjustments to reconcile net income to net cash from operating activities:
        		                                            
          proceeds from the sale of common stock under the stock purchase agreement
        		                                            
          landlord tenant incentive included in other current assets
        		                                            
          public offering costs included in accounts payable
        		                                            
          purchases of property and equipment financed with landlord tenant incentive
        		                              1,312,000              
          operating lease liabilities
        		                       -1,787,000 -1,846,000 -2,500,000                   
          right of use operating asset
        		                        1,771,000 2,942,000                   
          right of use assets obtained in exchange for new operating lease liabilities
        		                                            
          supplemental disclosure of non-cash investing and financing activities
        		                                            
          public offering costs included in accrued expenses
        		                         259,000    105,000               
          supplemental disclosure of non-cash operating, investing and financing activities
        		                                            
          supplemental disclosure of non-cash investing activities
        		                                            
          non-cash licensing and consulting fees
        		                                      0 0 787,000 424,000   
          increase in restricted cash
        		                              0 0   0 0         
          net increase in cash and cash equivalents
        		                              171,319,000 1,466,000 -12,010,000 -23,057,000 -151,561,000 131,075,000 -110,677,000 112,927,000 -18,124,000 -19,357,000 111,072,000 -14,604,000 -8,961,000 87,600,000 
          cash and cash equivalents at beginning of period
        		                              0 0 0 168,517,000 0 0 0 186,753,000 0 0 0 127,766,000 0 0 
          cash and cash equivalents at end of period
        		                              171,319,000 1,466,000 -12,010,000 145,460,000 -151,561,000 131,075,000 -110,677,000 299,680,000 -18,124,000 -19,357,000 111,072,000 113,162,000 -8,961,000 87,600,000 
          supplemental disclosure of non-cash financing activities
        		                                            
          public offering costs included in accounts payable or accrued expenses
        		                                      161,000 -133,000     
          purchases of property and equipment included in accounts payable or accrued expenses
        		                                 64,000    279,000       
          proceeds from the issuance of series b preferred stock, net of issuance costs
        		                                          0 0 
          proceeds from the issuance of series c preferred stock, net of issuance costs
        		                                          0 0 
          accretion of redeemable convertible preferred stock to redemption value
        		                                          0 391,000 
          conversion of preferred stock to common stock
        		                                            
          proceeds from sales of marketable securities
        		                                            
          purchase of property and equipment
        		                                     -341,000 -38,000 21,000 -71,000 -110,000 -45,000 -78,000 
          payment of offering costs
        		                                     -599,000 -36,000 -90,000 -423,000 -35,000 -250,000 -1,128,000 
          proceeds from public offering of common stock, net of commissions and underwriting discounts
        		                                     141,000,000 0 0     
          deferred offering costs
        		                                            
          proceeds from the issuance of series a preferred stock, net of issuance costs
        		                                            
          proceeds from stock option exercise and employee stock purchase plan issuances
        		                                            
          depreciation and amortization
        		                                        32,000 22,000 16,000 13,000 
          accrued expenses and other
        		                                        35,000 261,000  1,186,000 
          proceeds from stock option exercises and restricted stock
        		                                            
          proceeds from the issuance of common stock and restricted stock
        		                                         147,000 1,000 37,000 
          deferred public offering costs included in accounts payable or accrued expenses
        		                                         151,000   
          licensing or consulting fees paid in common stock
        		                                          0 0 
          accrued expenses
        		                                            
          other liabilities
        		                                            
          proceeds from initial public offering of common stock, net of commissions and underwriting discounts
        		                                          0  
          conversion of redeemable convertible preferred stock to common stock
        		                                            
          changes in operating assets and liabilities
        		                                            
          proceeds from convertible notes payable
        		                                            
          initial public offering costs included in accounts payable or accrued expenses
        		                                            
          deferred initial public offering costs included in accounts payable or accrued expenses