Quarterly
Annual
| Unit: USD | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-12-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-12-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-12-31 | 2014-09-30 | 2014-06-30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
product revenue | 442,000 | 843,000 | 600,000 | 1,690,000 | 1,985,000 | 2,716,000 | 2,460,000 | 3,294,000 | 2,865,000 | 1,739,000 | 1,501,000 | 1,582,000 | 1,642,000 | 1,440,000 | 1,643,000 | 1,583,000 | 1,686,000 | 1,639,000 | 1,089,000 | 2,286,000 | 1,960,000 | 1,478,000 | 519,000 | |||||||||||||||||||||
collaboration revenue - related party | 13,827,000 | 11,426,000 | 11,028,000 | 7,420,000 | 6,212,000 | |||||||||||||||||||||||||||||||||||||||
other revenue | 236,000 | |||||||||||||||||||||||||||||||||||||||||||
total revenues | 14,063,000 | 12,816,000 | 11,871,000 | 8,654,000 | ||||||||||||||||||||||||||||||||||||||||
operating costs and expenses: | ||||||||||||||||||||||||||||||||||||||||||||
cost of revenues | 655,000 | 1,489,000 | 5,278,000 | 1,407,000 | 1,269,000 | |||||||||||||||||||||||||||||||||||||||
research and development | 22,759,000 | 37,022,000 | 54,576,000 | 62,564,000 | 71,734,000 | 64,330,000 | 101,919,000 | 97,161,000 | 92,826,000 | 89,295,000 | 81,553,000 | 77,297,000 | 78,018,000 | 75,443,000 | 83,497,000 | 66,170,000 | 58,056,000 | 81,706,000 | 74,078,000 | 73,320,000 | 63,610,000 | 91,250,000 | 102,108,000 | 89,059,000 | 86,398,000 | 88,805,000 | 75,052,000 | 68,980,000 | 49,270,000 | 50,891,000 | 58,286,000 | 55,900,000 | 45,200,000 | 42,004,000 | 29,075,000 | 26,096,000 | 23,581,000 | 20,376,000 | 17,478,000 | 18,603,000 | 12,900,000 | 8,945,000 | 6,601,000 | 4,381,000 |
selling, general and administrative | 57,591,000 | 54,645,000 | 53,219,000 | 55,983,000 | 52,574,000 | 55,109,000 | 78,142,000 | 75,565,000 | 65,708,000 | 67,329,000 | 61,482,000 | 52,411,000 | 46,477,000 | 51,599,000 | 48,706,000 | 43,346,000 | 39,847,000 | 53,498,000 | 35,099,000 | 38,224,000 | 70,130,000 | 85,129,000 | 88,502,000 | 88,227,000 | ||||||||||||||||||||
restructuring | 513,000 | -213,000 | 33,599,000 | -130,000 | -529,000 | 28,402,000 | ||||||||||||||||||||||||||||||||||||||
total operating costs and expenses | 81,518,000 | 115,010,000 | 113,073,000 | 119,954,000 | 125,577,000 | 120,046,000 | 214,565,000 | 172,931,000 | 158,764,000 | 156,767,000 | 143,219,000 | 129,908,000 | 124,781,000 | 127,129,000 | 132,334,000 | 109,664,000 | 98,090,000 | 135,210,000 | 108,797,000 | 140,056,000 | 133,910,000 | 176,598,000 | 190,747,000 | 177,330,000 | ||||||||||||||||||||
income from operations | -67,455,000 | -102,194,000 | -101,202,000 | -111,300,000 | -117,675,000 | -42,074,000 | -211,849,000 | -170,457,000 | -155,470,000 | -153,902,000 | -141,480,000 | -128,407,000 | -123,199,000 | -125,487,000 | -130,894,000 | -108,021,000 | -96,507,000 | 973,976,000 | -107,158,000 | -138,967,000 | -131,624,000 | -174,638,000 | -187,177,000 | -176,457,000 | -169,852,000 | -164,227,000 | -128,745,000 | -22,147,000 | -78,119,000 | -70,449,000 | -74,373,000 | -70,854,000 | -57,480,000 | -56,378,000 | -38,064,000 | -35,006,000 | -30,714,000 | -28,612,000 | -24,082,000 | -25,059,000 | -16,897,000 | -12,361,000 | -9,470,000 | -6,188,000 |
yoy | -42.68% | 142.89% | -52.23% | -34.70% | -24.31% | -72.66% | 49.74% | 32.75% | 26.19% | 22.64% | 8.09% | 18.87% | 27.66% | -112.88% | 22.15% | -22.27% | -26.68% | -657.71% | -42.75% | -21.25% | -22.51% | 6.34% | 45.39% | 696.75% | 117.43% | 133.11% | 73.11% | -68.74% | 35.91% | 24.96% | 95.39% | 102.41% | 87.15% | 97.04% | 58.06% | 39.69% | 81.77% | 131.47% | 154.30% | 304.96% | ||||
qoq | -33.99% | 0.98% | -9.07% | -5.42% | 179.69% | -80.14% | 24.28% | 9.64% | 1.02% | 8.78% | 10.18% | 4.23% | -1.82% | -4.13% | 21.17% | 11.93% | -109.91% | -1008.92% | -22.89% | 5.58% | -24.63% | -6.70% | 6.08% | 3.89% | 3.43% | 27.56% | 481.32% | -71.65% | 10.89% | -5.28% | 4.97% | 23.27% | 1.95% | 48.11% | 8.74% | 13.97% | 7.35% | 18.81% | -3.90% | 48.30% | 36.70% | 30.53% | 53.04% | |
operating margin % | -1489.18% | -53.96% | -7800.04% | -6889.94% | 87.81% | -6538.01% | -12760.97% | -5757.83% | -8910.10% | -5243.05% | -20212.71% | |||||||||||||||||||||||||||||||||
interest income | 5,223,000 | 6,398,000 | 7,642,000 | 8,431,000 | 9,204,000 | 9,467,000 | 10,274,000 | 10,173,000 | 8,830,000 | 6,793,000 | 4,127,000 | 2,102,000 | 1,168,000 | 751,000 | 692,000 | 732,000 | 708,000 | 834,000 | 1,347,000 | 2,686,000 | 4,729,000 | 5,915,000 | 7,227,000 | 8,220,000 | 6,442,000 | 5,851,000 | 5,817,000 | 5,137,000 | 3,529,000 | 1,043,000 | 677,000 | 672,000 | 707,000 | 494,000 | 275,000 | 266,000 | 175,000 | 63,000 | 53,000 | 41,000 | 21,000 | 4,000 | 3,000 | 1,000 |
other income | 18,000 | 18,000 | 9,000 | 15,000 | -12,000 | -99,000 | -55,000 | -41,000 | -188,000 | -37,000 | 30,000 | 45,000 | -24,000 | 24,000 | 31,000 | 44,000 | 35,000 | 85,000 | 76,000 | -66,000 | 155,000 | 70,000 | -8,000 | 16,000 | 4,000 | -12,000 | 10,000 | 32,000 | -8,000 | -16,000 | -23,000 | -20,000 | -5,000 | -17,000 | -7,000 | -7,000 | -4,000 | -13,000 | -6,000 | -9,000 | 5,000 | -4,000 | -1,000 | -5,000 |
net income | -62,214,000 | -95,778,000 | -93,551,000 | -102,854,000 | -108,483,000 | -32,706,000 | -201,630,000 | -160,325,000 | -146,828,000 | -147,146,000 | -137,323,000 | -126,260,000 | -122,055,000 | -124,712,000 | -130,171,000 | -107,245,000 | -95,764,000 | 974,895,000 | -105,735,000 | -136,347,000 | -126,740,000 | -168,653,000 | -179,958,000 | -168,221,000 | -163,406,000 | -158,388,000 | -122,918,000 | -16,978,000 | -74,598,000 | -69,422,000 | -73,719,000 | -70,202,000 | -56,778,000 | -55,901,000 | -37,796,000 | -34,747,000 | ||||||||
yoy | -42.65% | 192.85% | -53.60% | -35.85% | -26.12% | -77.77% | 46.83% | 26.98% | 20.30% | 17.99% | 5.49% | 17.73% | 27.45% | -112.79% | 23.11% | -21.34% | -24.44% | -678.05% | -41.24% | -18.95% | -22.44% | 6.48% | 46.40% | 890.82% | 119.05% | 128.15% | 66.74% | -75.82% | 31.39% | 24.19% | 95.04% | 102.04% | ||||||||||||
qoq | -35.04% | 2.38% | -9.04% | -5.19% | 231.69% | -83.78% | 25.76% | 9.19% | -0.22% | 7.15% | 8.76% | 3.45% | -2.13% | -4.19% | 21.38% | 11.99% | -109.82% | -1022.02% | -22.45% | 7.58% | -24.85% | -6.28% | 6.98% | 2.95% | 3.17% | 28.86% | 623.98% | -77.24% | 7.46% | -5.83% | 5.01% | 23.64% | 1.57% | 47.90% | 8.77% | |||||||||
net income margin % | -1372.85% | -41.95% | -7423.78% | -6480.40% | 87.89% | -6451.19% | -12520.39% | -5544.18% | -8604.74% | -5040.84% | -19269.30% | |||||||||||||||||||||||||||||||||
net income per share | -1.01 | -1.56 | -1.53 | -1.7 | -1.8 | -0.54 | -3.37 | -2.68 | -2.46 | -2.47 | -2.31 | -2.13 | -2.07 | -2.11 | -2.21 | -1.83 | -1.64 | 18.76 | -2.03 | -2.63 | -2.44 | -3.25 | -3.48 | -3.28 | -3.37 | -3.4 | -2.63 | -0.36 | -1.68 | -1.72 | -1.97 | -1.88 | -1.52 | -1.55 | -1.15 | -1.08 | -0.97 | -1 | -0.84 | -0.9 | -0.66 | 1.41 | -0.5 | -4.57 |
weighted-average number of common shares outstanding—basic and diluted | 61,857,573 | 60,765,913 | 61,116,524 | 60,538,319 | 60,136,198 | 59,836,441 | 59,912,378 | 59,769,640 | 59,674,127 | 59,428,123 | 59,266,322 | 59,028,858 | 58,819,548 | 58,582,569 | 58,374,219 | 51,981,468 | 51,926,074 | 51,908,760 | 50,833,837 | 51,704,687 | 51,257,640 | 48,491,834 | 46,121,194 | 46,706,770 | 46,541,716 | 44,325,371 | 38,113,678 | |||||||||||||||||
comprehensive loss: | ||||||||||||||||||||||||||||||||||||||||||||
other comprehensive items: | ||||||||||||||||||||||||||||||||||||||||||||
unrealized gain on marketable securities | -102 | -657 | 1,592 | 96 | 27 | 2,921 | 1,909 | -556 | 5,118 | -49 | -651 | -531 | -763 | 2,501 | -2,087 | -482 | 202 | 1,681 | 409 | -258 | -112 | 40 | -156 | -14 | 52 | 14 | 21 | 39 | ||||||||||||||||
total comprehensive loss | -62,316 | -96,435 | -91,959 | -102,758 | -108,456 | -29,785 | -199,721 | -160,881 | -141,710 | -99,465.25 | -138,334 | -128,931 | -130,596 | -83,475.25 | -130,192 | -107,294 | -96,415 | -92,292.75 | -106,498 | -133,846 | -128,827 | -169,135 | -179,756 | -166,540 | -162,997 | -158,646 | -123,030 | -16,938 | -74,754 | -69,436 | -73,667 | -70,188 | -56,757 | -55,968 | -37,870 | -34,708 | ||||||||
consists of related-party amounts of 0.2m for the quarter ended march 31, 2025 (see note 7). | ||||||||||||||||||||||||||||||||||||||||||||
other collaboration revenue | 948,000 | 634,000 | ||||||||||||||||||||||||||||||||||||||||||
total revenue | 7,902,000 | 77,972,000 | 2,716,000 | 2,474,000 | 1,109,186,000 | 1,639,000 | 1,089,000 | 2,286,000 | 1,960,000 | 3,570,000 | 873,000 | |||||||||||||||||||||||||||||||||
yoy | 56491.12% | -54.09% | 24.74% | |||||||||||||||||||||||||||||||||||||||||
qoq | -89.87% | 2770.84% | 9.78% | 67574.56% | 50.51% | -52.36% | 16.63% | -45.10% | 308.93% | |||||||||||||||||||||||||||||||||||
collaboration revenue | 3,500 | 14,000 | 2,092,000 | 354,000 | 465,000 | 273,000 | 90,000,000 | |||||||||||||||||||||||||||||||||||||
cost of goods sold | 334,750 | 905,000 | 205,000 | 230,000 | 143,000 | 184,000 | 200,000 | 286,000 | 87,000 | 131,000 | 148,000 | 187,000 | 136,000 | 149,000 | 110,000 | 170,000 | 219,000 | 137,000 | 44,000 | |||||||||||||||||||||||||
total other comprehensive gain | 1,617.75 | 1,909 | -556 | 5,118 | -49 | -651 | -531 | -763 | 2,501 | -2,087 | -482 | 202 | 1,681 | 409 | -258 | -112 | 40 | -156 | -14 | 52 | 14 | 21 | 39 | |||||||||||||||||||||
unrealized loss on marketable securities | 4,677 | -1,011 | -2,671 | -8,541 | -180.25 | -21 | -67 | -74 | ||||||||||||||||||||||||||||||||||||
total other comprehensive loss | 4,677 | -1,011 | -2,671 | -8,541 | -180.25 | -21 | -67 | -74 | ||||||||||||||||||||||||||||||||||||
operating expenses: | ||||||||||||||||||||||||||||||||||||||||||||
general and administrative | 83,919,000 | 75,695,000 | 53,693,000 | 43,167,000 | 28,849,000 | 19,558,000 | 16,087,000 | 14,954,000 | 12,280,000 | 14,374,000 | 8,989,000 | 8,910,000 | 7,133,000 | 8,236,000 | 6,604,000 | 6,456,000 | 3,997,000 | 3,416,000 | 2,869,000 | 1,807,000 | ||||||||||||||||||||||||
total operating expenses | 170,317,000 | 164,500,000 | 128,745,000 | 112,147,000 | 78,119,000 | 70,449,000 | 74,373,000 | 70,854,000 | 57,480,000 | 56,378,000 | 38,064,000 | 35,006,000 | 30,714,000 | 28,612,000 | 24,082,000 | 25,059,000 | 16,897,000 | 12,361,000 | 9,470,000 | 6,188,000 | ||||||||||||||||||||||||
weighted-average common shares outstanding—basic and diluted | 37,470,912 | 37,361,129 | 37,269,148 | 32,975,897 | ||||||||||||||||||||||||||||||||||||||||
weighted-average shares outstanding—basic and diluted | 32,062,298 | |||||||||||||||||||||||||||||||||||||||||||
net income and comprehensive loss | -30,543,000 | -28,562,000 | -24,035,000 | -25,027,000 | -16,871,000 | -12,361,000 | -9,468,000 | -6,192,000 | ||||||||||||||||||||||||||||||||||||
weighted-average number of common shares used in net income per share—basic and diluted | 31,643,216 | |||||||||||||||||||||||||||||||||||||||||||
accretion of redeemable convertible preferred stock to redemption value | -391,000 | -1,577,000 | ||||||||||||||||||||||||||||||||||||||||||
net income attributable to common stockholders | -28,562,000 | -24,035,000 | -25,027,000 | -16,871,000 | -12,361,000 | -9,859,000 | -7,769,000 | |||||||||||||||||||||||||||||||||||||
weighted-average number of common shares used in net income per share attributable to common stockholders—basic and diluted | 33,492,795 | 27,778,288 | 28,737,743 | 27,860,332 | 25,655,883 | 21,574,347 | 19,581,624 | 1,700,517 | ||||||||||||||||||||||||||||||||||||
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