Quarterly
Annual
| Unit: USD | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
assets | |||||||||||||||||||||||||||||||
current assets: | |||||||||||||||||||||||||||||||
cash and cash equivalents | 238,000,000 | 248,000,000 | 192,000,000 | 150,000,000 | 201,000,000 | 156,000,000 | 185,000,000 | 127,000,000 | 184,000,000 | 230,000,000 | 238,000,000 | 206,000,000 | 217,647,000 | 272,629,000 | 548,783,000 | 147,914,000 | 179,432,000 | 320,482,000 | 390,260,000 | 173,415,000 | 221,849,000 | 285,185,000 | 67,326,000 | 57,937,000 | 78,992,000 | 76,068,000 | 68,499,000 | 71,064,000 | 74,889,000 | 169,998,000 | 198,116,000 |
marketable securities | 593,000,000 | 663,000,000 | 805,000,000 | 828,000,000 | 888,000,000 | 813,000,000 | 810,000,000 | 632,000,000 | 615,000,000 | 700,000,000 | 716,000,000 | 803,000,000 | |||||||||||||||||||
receivable from collaboration partners | 11,000,000 | 15,000,000 | 15,000,000 | 20,000,000 | 16,000,000 | 28,000,000 | 35,000,000 | 38,000,000 | 52,000,000 | 34,000,000 | 33,000,000 | 39,000,000 | 27,286,000 | 35,831,000 | 29,419,000 | 744,595,000 | 871,000 | 1,575,000 | 5,235,000 | 1,049,000 | 2,579,000 | 222,000 | 344,000 | 5,276,000 | |||||||
prepaid expenses and other current assets | 15,000,000 | 20,000,000 | 19,000,000 | 18,000,000 | 22,000,000 | 25,000,000 | 34,000,000 | 34,000,000 | 31,000,000 | 22,000,000 | 28,000,000 | 21,625,000 | 15,672,000 | 18,527,000 | 15,620,000 | 17,574,000 | 21,967,000 | 8,680,000 | 5,471,000 | 11,816,000 | 8,665,000 | 8,007,000 | 4,303,000 | 4,223,000 | 3,273,000 | 3,080,000 | 2,321,000 | 2,329,000 | 1,550,000 | 1,834,000 | |
total current assets | 857,000,000 | 946,000,000 | 1,031,000,000 | 1,016,000,000 | 1,127,000,000 | 1,022,000,000 | 1,064,000,000 | 831,000,000 | 882,000,000 | 986,000,000 | 1,015,000,000 | 1,067,000,000 | 1,101,116,000 | 1,227,475,000 | 1,264,226,000 | 1,261,750,000 | 545,288,000 | 745,954,000 | 841,870,000 | 735,815,000 | 797,199,000 | 471,599,000 | 166,217,000 | 192,705,000 | 200,488,000 | 227,733,000 | 245,015,000 | 258,948,000 | 265,280,000 | 267,441,000 | 282,068,000 |
long-term marketable securities | 10,000,000 | 16,000,000 | 8,000,000 | 14,000,000 | 2,000,000 | 40,000,000 | 100,000,000 | 107,000,000 | 151,000,000 | 80,000,000 | 90,000,000 | 129,000,000 | |||||||||||||||||||
property and equipment | 42,000,000 | 44,000,000 | 46,000,000 | 47,000,000 | 48,000,000 | 49,000,000 | 51,000,000 | 51,000,000 | 50,000,000 | 45,000,000 | 37,000,000 | 35,000,000 | 33,892,000 | 33,416,000 | 33,481,000 | 32,455,000 | 28,818,000 | 23,806,000 | 14,849,000 | 10,807,000 | 8,728,000 | 8,264,000 | 8,761,000 | 9,330,000 | 10,011,000 | 10,362,000 | 11,026,000 | 11,107,000 | 11,762,000 | ||
other noncurrent assets | 65,000,000 | 69,000,000 | 71,000,000 | 73,000,000 | 75,000,000 | 75,000,000 | 78,000,000 | 106,000,000 | 108,000,000 | 109,000,000 | 112,000,000 | 114,000,000 | |||||||||||||||||||
total assets | 974,000,000 | 1,075,000,000 | 1,156,000,000 | 1,150,000,000 | 1,252,000,000 | 1,186,000,000 | 1,293,000,000 | 1,095,000,000 | 1,191,000,000 | 1,220,000,000 | 1,254,000,000 | 1,345,000,000 | 1,393,822,000 | 1,476,773,000 | 1,543,427,000 | 1,591,898,000 | 839,290,000 | 898,773,000 | 935,119,000 | 772,292,000 | 811,075,000 | 481,389,000 | 176,144,000 | 203,110,000 | 216,957,000 | 238,974,000 | 258,530,000 | 274,925,000 | 286,721,000 | 293,865,000 | 305,399,000 |
liabilities and stockholders' equity | |||||||||||||||||||||||||||||||
current liabilities: | |||||||||||||||||||||||||||||||
accounts payable | 42,000,000 | 29,000,000 | 22,000,000 | 18,000,000 | 13,000,000 | 15,000,000 | 16,000,000 | 17,000,000 | 17,000,000 | 12,000,000 | 28,000,000 | 20,000,000 | 10,546,000 | 21,984,000 | 18,094,000 | 10,261,000 | 13,219,000 | 16,957,000 | 24,544,000 | 15,682,000 | 8,102,000 | 12,052,000 | 2,426,000 | 4,704,000 | 2,905,000 | 2,448,000 | 2,829,000 | 3,102,000 | 2,109,000 | 5,388,000 | 3,920,000 |
deferred revenue | 52,000,000 | 71,000,000 | 72,000,000 | 85,000,000 | 105,000,000 | 113,000,000 | 124,000,000 | 91,000,000 | 103,000,000 | 103,000,000 | 97,000,000 | 97,000,000 | |||||||||||||||||||
other current liabilities | 141,000,000 | 110,000,000 | 98,000,000 | 123,000,000 | 97,000,000 | 71,000,000 | 64,000,000 | 76,000,000 | 80,000,000 | 65,000,000 | 54,000,000 | 76,000,000 | 2,984,000 | 2,466,000 | 52,000 | 209,000 | 380,000 | 2,381,000 | 3,566,000 | 3,422,000 | 1,463,000 | 1,408,000 | 1,480,000 | 1,490,000 | 1,513,000 | 1,545,000 | 1,560,000 | 1,585,000 | 1,650,000 | 1,732,000 | |
total current liabilities | 235,000,000 | 210,000,000 | 192,000,000 | 226,000,000 | 215,000,000 | 199,000,000 | 204,000,000 | 184,000,000 | 200,000,000 | 180,000,000 | 179,000,000 | 193,000,000 | 177,176,000 | 164,024,000 | 161,254,000 | 166,084,000 | 142,866,000 | 130,370,000 | 132,055,000 | 121,669,000 | 162,871,000 | 40,025,000 | 21,004,000 | 22,706,000 | 21,057,000 | 26,513,000 | 19,003,000 | 16,935,000 | 16,611,000 | 16,380,000 | 14,262,000 |
deferred revenue, noncurrent | 53,000,000 | 60,000,000 | 219,000,000 | 234,000,000 | 289,000,000 | 214,000,000 | 242,000,000 | 307,000,000 | 326,000,000 | 330,000,000 | 330,000,000 | 355,000,000 | 382,584,000 | 429,339,000 | 456,905,000 | 462,217,000 | 94,675,000 | 103,908,000 | 113,369,000 | 122,830,000 | 91,298,000 | 8,522,000 | 10,272,000 | 12,022,000 | 13,772,000 | 10,522,000 | 12,272,000 | 16,984,000 | 18,546,000 | 16,087,000 | 17,337,000 |
long-term debt | 98,000,000 | 97,000,000 | 48,000,000 | 48,000,000 | 47,000,000 | ||||||||||||||||||||||||||
other noncurrent liabilities | 152,000,000 | 159,000,000 | 166,000,000 | 157,000,000 | 136,000,000 | 138,000,000 | 140,000,000 | 142,000,000 | 145,000,000 | 144,000,000 | 145,000,000 | 140,000,000 | |||||||||||||||||||
commitments | |||||||||||||||||||||||||||||||
stockholders’ equity: | |||||||||||||||||||||||||||||||
common shares, ... | 1,815,000,000 | 1,793,000,000 | 1,775,000,000 | 1,617,000,000 | 1,602,000,000 | 1,582,000,000 | 1,561,000,000 | 1,311,000,000 | 1,291,000,000 | 1,267,000,000 | 1,226,000,000 | 1,206,000,000 | |||||||||||||||||||
accumulated deficit | -1,379,000,000 | -1,244,000,000 | -1,244,000,000 | -1,132,000,000 | -1,038,000,000 | -946,000,000 | -853,000,000 | -849,000,000 | -768,000,000 | -697,000,000 | -622,000,000 | -542,000,000 | -474,898,000 | -409,979,000 | -343,347,000 | -275,354,000 | -554,722,000 | -476,747,000 | -400,777,000 | -328,184,000 | -276,331,000 | -278,153,000 | -233,079,000 | -205,326,000 | -188,728,000 | -166,376,000 | -138,286,000 | -122,828,000 | -110,533,000 | -99,722,000 | -86,188,000 |
total stockholders’ equity | 436,000,000 | 549,000,000 | 531,000,000 | 485,000,000 | 565,000,000 | 635,000,000 | 707,000,000 | 462,000,000 | 520,000,000 | 566,000,000 | 600,000,000 | 657,000,000 | 698,701,000 | 747,386,000 | 796,579,000 | 841,450,000 | 542,607,000 | 604,555,000 | 664,790,000 | 502,304,000 | 544,417,000 | 428,710,000 | 140,638,000 | 163,842,000 | 177,227,000 | 196,646,000 | 221,567,000 | 234,942,000 | 245,121,000 | 254,574,000 | 266,591,000 |
total liabilities and stockholders’ equity | 974,000,000 | 1,075,000,000 | 1,156,000,000 | 1,150,000,000 | 1,252,000,000 | 1,186,000,000 | 1,293,000,000 | 1,095,000,000 | 1,191,000,000 | 1,220,000,000 | 1,254,000,000 | 1,345,000,000 | 1,393,822,000 | 1,476,773,000 | 1,543,427,000 | 1,591,898,000 | 839,290,000 | 898,773,000 | 935,119,000 | 772,292,000 | 811,075,000 | 481,389,000 | 203,110,000 | ||||||||
accumulated other comprehensive loss | 1,000,000 | -1,000,000 | -1,000,000 | -3,000,000 | -4,000,000 | -4,000,000 | -7,000,000 | -9,801,000 | -7,244,000 | -4,660,000 | -107,000 | -108,000 | -83,000 | -97,000 | |||||||||||||||||
preferred stock, 0.0001 par value per share; 10.0 shares authorized; no shares issued and outstanding. | |||||||||||||||||||||||||||||||
prepaid and other current assets | 19,000,000 | ||||||||||||||||||||||||||||||
preferred stock: 0.0001 par value per share; 10.0 shares authorized; no shares issued and outstanding | |||||||||||||||||||||||||||||||
short-term investments | 831,135,000 | 900,147,000 | 664,751,000 | 351,394,000 | 345,210,000 | 400,530,000 | 436,666,000 | 555,231,000 | 560,583,000 | 177,288,000 | 90,540,000 | 130,333,000 | 111,997,000 | 148,330,000 | 173,436,000 | 185,480,000 | 182,948,000 | 95,700,000 | 82,064,000 | ||||||||||||
accrued interest receivable | 3,423,000 | 3,196,000 | 2,746,000 | 2,227,000 | 2,201,000 | 1,400,000 | 1,029,000 | 649,000 | 372,000 | 239,000 | |||||||||||||||||||||
long-term investments | 143,138,000 | 98,329,000 | 128,836,000 | 181,990,000 | 218,730,000 | 84,096,000 | 57,986,000 | 6,440,000 | 2,700,000 | 5,992,000 | 1,201,000 | 3,181,000 | 7,746,000 | 11,792,000 | 10,595,000 | ||||||||||||||||
right-of-use assets | 102,073,000 | 104,025,000 | 102,992,000 | 104,968,000 | 35,553,000 | 36,137,000 | 12,243,000 | 12,781,000 | |||||||||||||||||||||||
restricted cash | 3,005,000 | 3,005,000 | 3,005,000 | 3,005,000 | 3,005,000 | 3,005,000 | 1,988,000 | 203,000 | 203,000 | 203,000 | 203,000 | 203,000 | 203,000 | 203,000 | 203,000 | 203,000 | 203,000 | 203,000 | 203,000 | ||||||||||||
other long-term assets | 10,598,000 | 10,523,000 | 10,887,000 | 7,730,000 | 7,896,000 | 5,775,000 | 6,183,000 | 6,246,000 | 2,245,000 | 1,323,000 | 963,000 | 872,000 | 263,000 | 319,000 | 315,000 | 284,000 | 205,000 | 205,000 | 205,000 | ||||||||||||
accrued research and development | 39,827,000 | 35,019,000 | 37,654,000 | 29,587,000 | 40,470,000 | ||||||||||||||||||||||||||
other accrued liabilities | 20,528,000 | 14,438,000 | 16,196,000 | 24,181,000 | 14,625,000 | 9,706,000 | 7,536,000 | 9,543,000 | 7,496,000 | 5,611,000 | |||||||||||||||||||||
deferred revenue, current | 103,291,000 | 90,117,000 | 89,310,000 | 102,003,000 | 74,343,000 | 74,571,000 | 74,571,000 | 74,571,000 | 115,614,000 | 7,000,000 | 7,000,000 | 7,000,000 | 7,000,000 | 7,000,000 | 7,000,000 | 6,250,000 | 6,250,000 | 5,000,000 | 5,000,000 | ||||||||||||
operating lease liabilities, noncurrent | 119,195,000 | 121,343,000 | 114,815,000 | 116,887,000 | 48,943,000 | 49,741,000 | 14,706,000 | 15,243,000 | |||||||||||||||||||||||
other long-term liabilities | 16,166,000 | 14,681,000 | 13,874,000 | 5,260,000 | 10,199,000 | 10,199,000 | 10,199,000 | 10,246,000 | 8,178,000 | 693,000 | 640,000 | 806,000 | 1,026,000 | 1,283,000 | 1,543,000 | 1,792,000 | 2,047,000 | 2,308,000 | 2,554,000 | ||||||||||||
total liabilities | 695,121,000 | 729,387,000 | 746,848,000 | 750,448,000 | 296,683,000 | 294,218,000 | 270,329,000 | 269,988,000 | 266,658,000 | 52,679,000 | 35,506,000 | 39,268,000 | 39,730,000 | 42,328,000 | 36,963,000 | 39,983,000 | 41,600,000 | 39,291,000 | 38,808,000 | ||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized; no shares issued and outstanding. | |||||||||||||||||||||||||||||||
common stock | 7,000 | 7,000 | 7,000 | 7,000 | 7,000 | 7,000 | 7,000 | 6,000 | 6,000 | 6,000 | 4,000 | 4,000 | 4,000 | 4,000 | 4,000 | 4,000 | 4,000 | ||||||||||||||
additional paid-in capital | 1,183,393,000 | 1,164,602,000 | 1,144,579,000 | 1,118,058,000 | 1,097,414,000 | 1,081,341,000 | 1,065,562,000 | 830,438,000 | 820,661,000 | 706,713,000 | 373,425,000 | 369,100,000 | 365,898,000 | 362,905,000 | 359,820,000 | 357,873,000 | 355,758,000 | 354,375,000 | 352,872,000 | ||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of june 30, 2022 and december 31, 2021; no shares issued and outstanding as of june 30, 2022 and december 31, 2021 | |||||||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of march 31, 2022 and december 31, 2021; no shares issued and outstanding as of march 31, 2022 and december 31, 2021 | |||||||||||||||||||||||||||||||
liabilities | |||||||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of december 31, 2021 and 2020; no shares issued and outstanding as of december 31, 2021 and 2020 | |||||||||||||||||||||||||||||||
accumulated other comprehensive income | -1,261,000 | -92,000 | -46,000 | -2,000 | 44,000 | 81,000 | 144,000 | 288,000 | 64,000 | 53,000 | 113,000 | 29,000 | |||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of september 30, 2021 and december 31, 2020; no shares issued and outstanding as of september 30, 2021 and december 31, 2020 | |||||||||||||||||||||||||||||||
accrued research and development expenses | 28,756,000 | 23,023,000 | 18,307,000 | 28,237,000 | 13,899,000 | ||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of june 30, 2021 and december 31, 2020; no shares issued and outstanding as of june 30, 2021 and december 31, 2020 | |||||||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of march 31, 2021 and december 31, 2020; no shares issued and outstanding as of march 31, 2021 and december 31, 2020 | |||||||||||||||||||||||||||||||
deferred rent, non-current | |||||||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of december 31, 2020 and 2019; no shares issued and outstanding as of december 31, 2020 and 2019 | |||||||||||||||||||||||||||||||
current liabilities | |||||||||||||||||||||||||||||||
deferred rent, noncurrent | 4,311,000 | ||||||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of september 30, 2020 and december 31, 2019; no shares issued and outstanding as of september 30, 2020 and december 31, 2019 | |||||||||||||||||||||||||||||||
deferred rent | 3,439,000 | 3,590,000 | 3,734,000 | 3,875,000 | 4,010,000 | 4,145,000 | 4,272,000 | 4,396,000 | 4,516,000 | 4,655,000 | |||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of june 30, 2020 and december 31, 2019; no shares issued and outstanding as of june 30, 2020 and december 31, 2019 | |||||||||||||||||||||||||||||||
accrued liabilities | 10,170,000 | 9,522,000 | 9,662,000 | 15,552,000 | 7,629,000 | 6,023,000 | 6,667,000 | 4,342,000 | 3,610,000 | ||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of march 31, 2020 and december 31, 2019; no shares issued and outstanding as of march 31, 2020 and december 31, 2019 | |||||||||||||||||||||||||||||||
total liabilities, convertible preferred stock and stockholders’ equity | 176,144,000 | 216,957,000 | 238,974,000 | 258,530,000 | 274,925,000 | 286,721,000 | 293,865,000 | 305,399,000 | |||||||||||||||||||||||
receivable from collaboration partner | 132,000 | 5,000,000 | |||||||||||||||||||||||||||||
amounts owed by a related party | 62,000 | 83,000 | 114,000 | 193,000 | 54,000 | ||||||||||||||||||||||||||
equity investment in related party | 357,000 | 770,000 | 1,202,000 | 1,525,000 | 1,711,000 | 515,000 | |||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of december 31, 2019 and 2018; no shares issued and outstanding as of december 31, 2019 and 2018 | |||||||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of september 30, 2019 and december 31, 2018; no shares issued and outstanding as of september 30, 2019 and december 31, 2018 | |||||||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of june 30, 2019 and december 31, 2018; no shares issued and outstanding as of june 30, 2019 and december 31, 2018 | |||||||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of march 31, 2019 and december 31, 2018; no shares issued and outstanding as of march 31, 2019 and december 31, 2018 | |||||||||||||||||||||||||||||||
convertible preferred stock | |||||||||||||||||||||||||||||||
stockholders’ equity | |||||||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of december 31, 2018; no shares issued and outstanding | |||||||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares and no shares authorized as of september 30, 2018 and december 31, 2017, respectively; no shares issued and outstanding as of september 30, 2018 and december 31, 2017, respectively | |||||||||||||||||||||||||||||||
property, plant and equipment-net | 12,513,000 | 11,813,000 | |||||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares and no shares authorized as of june 30, 2018 and december 31, 2017, respectively; no shares issued and outstanding as of june 30, 2018 and december 31, 2017, respectively | |||||||||||||||||||||||||||||||
common stock; 0.0001 par value; 400,000,000 and 153,993,227 shares authorized as of june 30, 2018 and december 31, 2017, respectively; 44,456,659 and 4,090,898 shares issued and outstanding as of june 30, 2018 and december 31, 2017 respectively | 4,000 | ||||||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares and no shares authorized as of march 31, 2018 and december 31, 2017, respectively; no shares issued and outstanding as of march 31, 2018 and december 31, 2017, respectively | |||||||||||||||||||||||||||||||
common stock; 0.0001 par value; 400,000,000 and 153,993,227 shares authorized as of march 31, 2018 and december 31, 2017, respectively; 44,454,275 and 4,090,898 shares issued and outstanding as of march 31, 2018 and december 31, 2017 respectively | 4,000 |
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