7Baggers
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-09-30 2016-06-30 2016-03-31 2015-09-30 2015-06-30 2015-03-31 2014-09-30 2014-06-30 2014-03-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 2004-03-31 2003-12-31 2003-09-30 2003-06-30 2003-03-31 2002-12-31 2002-09-30 2002-06-30 2002-03-31 
      
    		                                                                                           
      operating activities
    		                                                                                           
      net income
    		-370,021,000 -321,686,000 -256,583,000 -235,548,000 -220,524,000 -300,609,000 -157,091,000 -186,061,000 -158,933,000 -244,809,000 -159,764,000 -160,123,000 -131,145,000 -95,645,000 -94,621,000 -112,978,000 -112,714,000 -117,321,000 -91,641,000 -102,213,000 -63,659,000 -61,854,000 -66,364,000 -52,988,000 -60,682,000 -66,514,000 -74,153,000 -91,573,000 -87,743,000 -76,437,000 -68,524,000 -65,384,000 -45,179,000 -44,672,000 -37,414,000 -37,760,000 -36,579,000 -33,532,000 -30,962,000 -28,607,000 -27,369,000 -23,990,000 -23,224,000 -14,298,000 -17,327,000 -8,854,000 -13,678,000 -15,451,000 -9,382,000 -9,696,000 -6,845,000 -8,162,000 -34,590,000 -10,018,000 -6,894,000 -5,844,000 -330,000 -378,000 118,000 2,306,000 -150,000 -1,601,000 117,795,000 -3,964,000 -2,163,000 -4,667,000 -4,873,000 -3,297,000 -3,912,000 -2,500,000 -10,253,000 -21,428,000 -12,372,000 -8,912,000 -13,427,000 -12,885,000 -13,756,000 -8,524,000 -5,764,000 -5,837,000 -7,596,000 -9,011,000 -4,759,000 -2,451,000 -2,398,000 -3,240,000 -2,209,000 -18,497,000   -6,107,000 
      adjustments to reconcile net income to net cash from operating activities:
    		                                                                                           
      depreciation
    		2,458,000 2,484,000 1,883,000 1,478,000 1,459,000 1,436,000 1,588,000 1,475,000 1,493,000 1,311,000 1,248,000 2,183,000 851,000 958,000 1,286,000 2,119,000 2,238,000 2,385,000 2,388,000 2,318,000 2,295,000 2,268,000 2,266,000 1,939,000 1,004,000 1,176,000 1,069,000 925,000 954,000 929,000 769,000  714,000 738,000 716,000 674,000 568,000 514,000 463,000 447,000 432,000                                       3,000 7,000 10,000 14,000 15,000 23,000 28,000 30,000 22,000 92,000 114,000 118,000 
      amortization of intangible assets
    		1,538,000 1,263,000 1,263,000 1,263,000 1,263,000 1,263,000 1,263,000 1,263,000 1,263,000 1,263,000 1,263,000 1,264,000 1,263,000 1,263,000 1,263,000 1,262,000 1,264,000 1,263,000 1,263,000 1,258,000 1,248,000 1,248,000 1,249,000 1,248,000 1,249,000 1,248,000 1,248,000                                                                 
      stock-based compensation expense
    		31,433,000 42,976,000 39,262,000 26,554,000 25,545,000 23,286,000 21,450,000 19,983,000 19,993,000 18,359,000 16,443,000 14,950,000 15,654,000 14,259,000 12,823,000 11,520,000 12,231,000 11,735,000 10,535,000 8,779,000 8,909,000 9,468,000 9,002,000 5,888,000 6,794,000 7,353,000 6,936,000 6,035,000 7,902,000 6,629,000 5,674,000 4,741,000 4,741,000                                                           
      amortization of debt issuance costs
    		1,342,000 1,676,000 1,822,000 1,748,000 1,485,000 1,800,000 1,851,000 1,752,000 1,840,000 2,004,000 1,724,000      541,000 457,000 350,000 349,000 350,000 349,000 349,000 350,000 349,000 349,000 349,000 350,000 415,000 286,000 299,000 27,000                                                            
      paid-in-kind interest capitalized
    		   0 6,662,000 6,329,000 6,242,000 6,170,000 6,001,000 5,745,000 5,456,000                                                                                 
      royalty financing non-cash interest expense
    		5,129,000 5,192,000 5,023,000 5,065,000 5,264,000 4,893,000 4,822,000 4,830,000 10,170,000 1,231,000 2,615,000                                                                                 
      accretion of discount on marketable securities
    		-12,041,000 -7,578,000 -8,332,000 -11,027,000 -6,170,000 0 -1,963,000 -3,092,000                                                                                    
      finance lease amortization expense
    		678,000 678,000 678,000 678,000 678,000 678,000 678,000 678,000 678,000 678,000 678,000 114,000 481,000 636,000 729,000 269,000 270,000 269,000 270,000 269,000 89,000 360,000 360,000                                                                     
      non-cash operating lease expense
    		1,174,000 888,000 686,000 1,358,000 619,000 -4,905,000 6,516,000 783,000 1,124,000 4,808,000 2,491,000                                                                                 
      change in fair value of deferred and contingent consideration liabilities
    		104,653,000 59,000,000 18,300,000 -14,800,000 14,682,000 103,700,000 -11,900,000 15,700,000 8,997,000 13,500,000 -9,500,000 -1,800,000 5,238,000 -12,622,000 -11,618,000 -966,000                                                                            
      change in fair value of interest rate swap
    		   -870,000 3,852,000 -384,000 -2,362,000 -1,970,000 1,301,000 -1,184,000 1,533,000                                                                                 
      changes in operating assets and liabilities:
    		                                                                                           
      accounts receivable
    		-10,226,000 -6,142,000 5,361,000 -11,817,000 -35,000 -4,035,000 2,955,000 -4,535,000 -5,137,000 -1,431,000 -860,000 -983,000 1,344,000 -4,986,000 -1,798,000 -5,243,000 -1,020,000 -789,000 -1,066,000 -1,366,000 -23,000 1,981,000 2,078,000 -3,886,000 -3,708,000 -2,291,000 -3,832,000                     0 0 0 757,000 -317,000 -137,000 -134,000 302,000 -48,000 12,000 -1,000 56,000 74,000 -108,000 -97,000 8,000 -50,000 -22,000 277,000 -77,000 -225,000 -25,000 111,000 130,000 9,000 -145,000                   
      inventory
    		-13,758,000 -4,976,000 -1,021,000 -2,122,000 -6,569,000 -7,755,000 -598,000 -4,434,000 -1,098,000 -6,894,000 -1,187,000 -2,338,000 -100,000 -1,516,000 2,240,000 1,132,000 -7,031,000 -8,803,000 -2,754,000 -6,064,000 -7,956,000 -4,828,000 -2,332,000 -5,000,000 -3,153,000 -7,478,000 -5,650,000                                         0 0 0 576,000  -24,000                   
      prepaid expenses and other current assets
    		-3,732,000 -6,534,000 -16,941,000 2,799,000 842,000 1,507,000 -19,330,000 3,461,000 -1,041,000 3,044,000 -3,199,000 722,000 -2,295,000 6,853,000 -2,752,000 -3,452,000 5,387,000 -9,540,000 2,056,000 -3,745,000 -4,793,000 1,083,000 4,341,000 1,438,000 -5,568,000 -3,527,000 -1,061,000                                                                 
      other assets
    		-2,851,000 2,347,000 10,168,000 2,710,000 -10,074,000 15,366,000 333,000 -3,169,000 -9,447,000 -2,227,000 -5,231,000 -12,220,000 2,508,000 -9,242,000 -6,289,000 -3,441,000 1,629,000 -2,892,000 -19,731,000 -1,475,000 -1,535,000 -1,683,000 -1,568,000 -703,000 -3,218,000 -5,043,000 -7,044,000                                  -91,000 -115,000 44,000 44,000 75,000 -83,000 134,000 -5,000 -28,000 -176,000 52,000 52,000 51,000 -157,000 50,000 49,000 58,000 -90,000 74,000 306,000 706,000 -802,000 -159,000 120,000 121,000 -339,000 488,000    103,000 
      accounts payable and accrued liabilities
    		45,559,000 25,658,000 -61,490,000 41,130,000 725,000 35,082,000 -32,345,000 21,709,000 -6,778,000 9,065,000 -8,841,000 34,874,000                                                                                
      other liabilities
    		-1,096,000 -815,000 -2,167,000 -4,578,000 -620,000 -604,000 -6,144,000 -5,362,000 -468,000 -3,736,000 -1,422,000 8,768,000                                                                       154,000 9,000 -31,000 -10,000 -121,000    -297,000 
      net cash from operating activities
    		-219,761,000 -205,569,000 -262,088,000 -195,979,000 -180,916,000 -122,952,000 -184,035,000 -130,819,000 -136,333,000 -122,792,000 -146,303,000 -103,149,000 -89,828,000 -102,301,000 -105,161,000 -84,132,000 -75,445,000 -75,444,000 -128,281,000 -66,792,000 -58,668,000 -35,953,000 -57,935,000 -44,404,000 -52,368,000 -80,030,000 -73,847,000 -69,538,000 -65,488,000 -54,912,000 -68,039,000 -48,221,000                -8,926,000 -9,188,000 -7,286,000 -5,612,000 -6,065,000 -8,008,000 -11,023,000 -5,109,000 -8,917,000 -1,040,000 2,004,000 231,000 775,000 -1,139,000 -8,554,000 -2,094,000 -2,880,000 -3,119,000 -2,097,000 -3,896,000 -3,212,000 -3,346,000 -6,824,000 -11,873,000 -10,803,000 -11,886,000 -7,837,000 -11,678,000 -6,209,000 -7,867,000 -7,394,000 -6,295,000 -6,452,000 -6,544,000 -7,286,000 -4,619,000 -2,683,000 -2,781,000 -3,066,000 -2,232,000 -3,859,000   -8,903,000 
      capex
    		0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0                0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0   0 
      free cash flows
    		-219,761,000 -205,569,000 -262,088,000 -195,979,000 -180,916,000 -122,952,000 -184,035,000 -130,819,000 -136,333,000 -122,792,000 -146,303,000 -103,149,000 -89,828,000 -102,301,000 -105,161,000 -84,132,000 -75,445,000 -75,444,000 -128,281,000 -66,792,000 -58,668,000 -35,953,000 -57,935,000 -44,404,000 -52,368,000 -80,030,000 -73,847,000 -69,538,000 -65,488,000 -54,912,000 -68,039,000 -48,221,000                -8,926,000 -9,188,000 -7,286,000 -5,612,000 -6,065,000 -8,008,000 -11,023,000 -5,109,000 -8,917,000 -1,040,000 2,004,000 231,000 775,000 -1,139,000 -8,554,000 -2,094,000 -2,880,000 -3,119,000 -2,097,000 -3,896,000 -3,212,000 -3,346,000 -6,824,000 -11,873,000 -10,803,000 -11,886,000 -7,837,000 -11,678,000 -6,209,000 -7,867,000 -7,394,000 -6,295,000 -6,452,000 -6,544,000 -7,286,000 -4,619,000 -2,683,000 -2,781,000 -3,066,000 -2,232,000 -3,859,000   -8,903,000 
      investing activities
    		                                                                                           
      purchase of fixed assets
    		-2,418,000 -3,484,000 -10,070,000 -6,772,000 -3,689,000 -6,783,000 -4,679,000 -2,153,000 -2,854,000 -4,883,000 -3,398,000 -4,691,000 -582,000 -2,904,000 -1,701,000 -1,142,000 -1,481,000 -3,485,000 -1,181,000 -933,000 -747,000 -1,881,000 -2,679,000 -13,038,000 -14,592,000 -10,610,000 -4,028,000 -3,027,000 -1,851,000 -2,847,000 -5,365,000 -1,700,000                -168,000 -27,000 -29,000 -66,000 -424,000 -487,000 -54,000 -14,000                                     
      purchase of marketable securities
    		-1,184,815,000 -276,681,000 -630,518,000 -577,470,000    -296,044,000 1,000   0 0 0 -99,706,000                                                                             
      maturities of marketable securities
    		425,000,000 508,000,000 721,000,000 716,000,000 0 0 300,000,000 300,000,000 10,000,000 20,000,000 45,000,000 25,000,000                                                                                
      net cash from investing activities
    		-762,233,000 227,835,000 80,412,000 131,758,000 -1,003,471,000 -6,783,000 295,321,000 1,803,000 7,147,000 -274,156,000 41,602,000 20,309,000 49,418,000 -2,904,000 -101,407,000 -51,218,000 -8,401,000 -3,485,000 -1,181,000 -1,515,000 -747,000 -1,881,000 -2,679,000 -13,038,000 -14,592,000 -10,610,000 -4,028,000 -4,751,000 -1,851,000 -2,847,000 -5,365,000 -1,700,000                44,589,000 -28,000 4,120,000 12,841,000 10,482,000 8,640,000 -1,249,000 16,487,000 9,976,000 -589,000 -10,053,000 6,624,000 -14,392,000 -6,873,000 -87,750,000 127,755,000 3,245,000 4,571,000 -744,000 5,601,000 9,066,000 0 0 -500,000 -517,000 -1,487,000                   
      financing activities
    		                                                                                           
      proceeds from exercise of stock options and espp
    		34,413,000 36,965,000 29,704,000 13,740,000 26,880,000 68,571,000 4,052,000 7,636,000 2,341,000 7,283,000 1,139,000               10,455,000 3,049,000                                                                 
      proceeds from issuance of common stock
    		-256,000   -12,000 370,978,000   114,461,000 0   258,770,000    0 0   1,000 -47,000   0 -104,000       -47,000       0         -1,000    0 0       0 0               4,368,000 88,000 78,000 87,000 8,165,000 4,000   20,000 12,962,000 -42,000 11,000 17,000 0 135,000 18,000 
      payments of principal of 0.75% convertible senior notes due 2028
    		0                                                                                           
      payments of finance lease principal
    		-747,000 -732,000 -706,000 -686,000 -658,000 -645,000 -621,000 1,166,000 -1,092,000 -971,000 -320,000  -336,000 -135,000 -359,000  -269,000 -264,000 -258,000  -179,000 -298,000 -292,000                                                                     
      net cash from financing activities
    		33,410,000 857,806,000 28,998,000 159,305,000 397,200,000 781,493,000 3,022,000 123,263,000 1,249,000 44,326,000 -399,000 743,387,000 37,116,000 6,311,000 6,459,000 5,710,000 2,536,000 597,597,000 6,703,000 12,011,000 6,102,000 250,756,000 2,134,000 9,238,000 1,358,000 271,633,000 3,049,000 1,797,000 605,000 5,549,000 378,792,000 433,000 378,222,000 1,869,000 565,000 9,692,000 47,000 81,000 825,000 225,643,000 1,475,000 108,438,000 -60,000 337,000 67,790,000 596,000 22,000 10,130,000 25,630,000 9,698,000 -34,000 -18,000 -22,000 11,000 -21,000 -3,000 0 1,000 -231,000 -229,000 -233,000 3,847,000 -518,000 -494,000 -557,000 -486,000 -553,000 778,000 0 17,047,000 297,000 443,000 6,000 2,000 52,050,000 4,368,000 88,000 78,000 32,844,000 8,165,000    20,000 12,962,000 -42,000 11,000 17,000 0 135,000 18,000 
      effect of exchange rates on cash and cash equivalents
    		-976,000 1,005,000 895,000 -1,505,000 1,839,000 -688,000 -953,000 1,014,000 2,168,000 -3,403,000 -29,000 -1,144,000 1,849,000 -732,000 -969,000 -134,000 -461,000 -92,000 -246,000 299,000 155,000 47,000 -7,000 1,000 -26,000 36,000 -15,000 -10,000 -21,000 -42,000 28,000 -25,000 77,000 39,000 12,000   31,000                                                      
      net decrease in cash and cash equivalents
    		        -125,769,000 -356,025,000 -105,129,000    -201,078,000    -123,005,000    -58,487,000                                                                     
      cash and cash equivalents at beginning of period
    		0 0 555,030,000 0 0 0 482,374,000 0 0 0 1,074,036,000 0 0 0 716,782,000 0 0 0 532,756,000 0 0 0 487,429,000 0 0 0 495,072,000 0 0 0 381,165,000 0 0 0 162,591,000 0 0 282,876,000 0 0 159,226,000 0 0 113,894,000 0 0 90,782,000 0 0 0 14,848,000 0 0 0 10,743,000 0 0 0 12,740,000 -252,000 0 0 2,397,000 0 0 0 3,554,000  0 0 24,112,000  0 0 18,835,000 0 0 0 9,222,000 0 0 0 29,526,000 0 0 0 27,337,000  0 0 51,250,000 
      cash and cash equivalents at end of period
    		-949,560,000 881,077,000 403,247,000 93,579,000 -785,348,000 651,070,000 595,729,000 -4,739,000 -125,769,000 -356,025,000 968,907,000 659,403,000 -1,445,000 -99,626,000 515,704,000 -129,774,000 -81,771,000 518,576,000 409,751,000 -55,997,000 -53,158,000 212,969,000 428,942,000 -48,203,000 -65,628,000 181,029,000 420,231,000 -72,502,000 -66,755,000 -52,252,000 686,581,000 -49,513,000 339,614,000 -34,775,000 125,839,000 -22,591,000 -29,763,000 252,872,000 -24,058,000 200,473,000 134,554,000 84,614,000 -18,554,000 101,251,000 53,437,000 -4,846,000 79,434,000 45,793,000 16,414,000 6,532,000 22,043,000 4,399,000 610,000 -12,261,000 22,100,000 1,056,000 -1,629,000 -8,048,000 19,364,000 -14,098,000 -8,245,000 -92,457,000 127,540,000 -129,000 895,000 -3,327,000 4,706,000  -3,346,000 10,223,000 12,036,000  -13,367,000 -10,851,000 59,207,000 -1,841,000 -7,779,000 -7,316,000 35,771,000 1,713,000 -6,546,000 -10,852,000 24,907,000 -2,663,000 10,181,000 -3,108,000 25,116,000  -5,086,000 -6,100,000 42,365,000 
      supplemental disclosures of cash flow information:
    		                                                                                           
      cash paid for interest
    		15,452,000 13,269,000 13,122,000 15,240,000 8,632,000 8,485,000 8,210,000 8,326,000 7,970,000 7,902,000 11,589,000 2,715,000 2,438,000 2,629,000 2,375,000 2,688,000 2,291,000 1,640,000 4,271,000 339,000 4,028,000 438,000 4,381,000 3,000 3,939,000 2,000 3,939,000 1,314,000 3,699,000 1,000 1,275,000 1,289,000 1,302,000 1,301,000 1,273,000 899,000 597,000 975,000 724,000 843,000 663,000 473,000 467,000 463,000 472,000 468,000 476,000 234,000 161,000 1,000 2,000 1,000 2,000      3,000 72,000 -52,000 24,000 38,000 52,000 53,000 61,000 68,000 68,000 70,000 70,000 71,000 71,000 83,000 82,000 83,000 281,000                
      cash paid for income taxes
    		1,177,000 677,000 2,176,000 248,000 689,000 354,000 1,208,000 75,000 518,000 358,000 1,004,000 91,000 432,000 559,000 635,000 107,000 454,000 325,000 672,000 34,000 308,000 58,000 414,000 19,000 120,000 22,000 178,000  34,000 39,000 54,000  21,000 24,000 17,000                                                         
      net increase in cash and cash equivalents
    		 881,077,000 -151,783,000   651,070,000 113,355,000     659,403,000 -1,445,000   -129,774,000 -81,771,000   -55,997,000 -53,158,000   -48,203,000 -65,628,000 181,029,000 -74,841,000 -72,502,000 -66,755,000 -52,252,000 305,416,000 -49,513,000       -24,058,000                                                     
      payments of equity issuance costs
    		      -409,000                                                                                     
      vertuis acquisition
    		       0 0 0 10,250,000                                                                                 
      adrestia acquisition
    		       0 0                                                                                   
      cash acquired in asset acquisition
    		       0 0                                                                                   
      proceeds from issuance of term loans
    		                                                                                           
      proceeds from issuance royalty financing agreement
    		                                                                                           
      payment of debt issuance costs
    		       0 0 0 -1,218,000     -16,000 311,000           -2,000 0 -94,000 -14,141,000                                                             
      loss on extinguishment of debt
    		               0 0           4,418,000 0 0 -2,209,000                                                             
      accretion of debt discount
    		                8,318,000 7,482,000 4,907,000  4,776,000      4,406,000 4,348,000 4,289,000 4,231,000 3,021,000                                                             
      cash paid for business acquisition
    		               216,000                                                                            
      payment on extinguishment of 1.75% convertible senior notes due 2025
    		               0 0                                                                           
      payment of principal of 1.75% convertible senior notes due 2025
    		                                                                                           
      proceeds from issuance of 0.75% convertible senior notes due 2028
    		               0 0                                                                           
      proceeds from issuance of term loan
    		                                                                                           
      noncash operating lease expense
    		           536,000 1,675,000 7,396,000 2,369,000 1,371,000 1,668,000 4,342,000 5,208,000 764,000 -604,000 4,236,000 1,536,000                                                                     
      pari milestone upon regulatory approvals
    		                                                                                           
      other financing activities
    		                                                                                           
      amortization of debt issuance costs and accretion of debt discount
    		            822,000 821,000 822,000                                                                             
      cash from business acquisition
    		                                                                                           
      proceeds from exercise of stock options, espp, and rsu vestings
    		            4,069,000 6,446,000 6,818,000                                                                             
      payment of principal on 1.75% convertible senior notes due 2025
    		                0                                                                           
      accounts payable
    		             -16,921,000 13,363,000 11,279,000 -7,696,000 9,115,000 -20,273,000 20,705,000 -3,055,000 8,006,000 4,169,000 -6,376,000 2,694,000 -10,783,000 9,499,000 1,334,000 555,000 2,809,000 -828,000 4,525,000 -1,688,000   -861,000 695,000 527,000    -1,096,000 -247,000 3,889,000  -319,000 1,124,000 4,075,000 -213,000 319,000 545,000 830,000 -417,000 -1,161,000 1,632,000 -2,869,000 -481,000 479,000 121,000 -269,000 -130,000 -1,956,000 1,390,000 160,000 29,000 284,000 -100,000 172,000 53,000 -3,571,000 -2,936,000 3,403,000 900,000 641,000 1,275,000 -1,026,000 63,000 390,000 -1,080,000 -1,359,000 373,000 1,833,000 1,114,000 22,000 -904,000 397,000 204,000 -1,765,000   -1,186,000 
      accrued liabilities, accrued compensation and other
    		             6,445,000 -22,978,000                                                                             
      proceeds from exercise of stock options, espp, and rsu vesting
    		                 6,566,000 6,961,000 12,177,000 6,328,000 5,142,000 2,426,000 4,735,000                                                                    
      accrued liabilities and other
    		                                                                                           
      accrued compensation
    		                3,760,000 5,780,000 -15,107,000 8,849,000 3,051,000 4,072,000 -10,191,000 5,186,000 3,736,000 -6,053,000 -5,937,000                     626,000 732,000 339,000 -285,000                                         
      accrued expenses and other
    		                 3,384,000 -4,686,000 -62,000 2,239,000 -5,372,000 -7,480,000 -6,210,000 3,609,000 7,067,000 323,000 9,320,000 8,802,000 8,077,000 -6,283,000 8,716,000    800,000                                                        
      accretion of debt discount and back-end fee on debt
    		                      4,650,000                                                                     
      proceeds from issuance of 1.75% convertible senior notes due 2025
    		                           0 0 0 450,000,000                                                             
      payment of debt principal and extinguishment costs
    		                                                                                           
      payment of financing lease principal
    		                                                                                           
      proceeds from tenant improvement allowance
    		                                                                                           
      pari milestone upon fda approval
    		                                                                                           
      payment on extinguishment of debt
    		                                                                                           
      payment of debt
    		                           0 0 0 -55,000,000                                                             
      accretion of debt discount and back-end fee
    		                        4,526,000                                                                   
      accretion of back-end fee on debt
    		                           0 0 0 50,000                                                             
      prepaid expenses and other assets
    		                           -1,199,000 -662,000 -1,436,000 -2,217,000 -1,731,000 -1,180,000 -224,000 352,000             -5,000 88,000 -526,000 263,000 138,000 12,000                                       
      proceeds from issuance of debt
    		                                                                                           
      cash paid for taxes
    		                                                0 2,000 2,000  0    136,000                                   
      proceeds from exercise of stock options
    		                            605,000 5,643,000 142,000 480,000 519,000 1,869,000 565,000 0 47,000 81,000 825,000 2,701,000 1,475,000 438,000 56,000 353,000 794,000 626,000 51,000                                             
      depreciation and amortization
    		                                         355,000 175,000 167,000 171,000 156,000 148,000 149,000 138,000 138,000 136,000 110,000 79,000 79,000 75,000 29,000 0 0 25,000 46,000 60,000 396,000 205,000 230,000 251,000 270,000 292,000 147,000 91,000 86,000 82,000 472,000 88,000 83,000 2,726,000 5,656,000 5,668,000 1,347,000 226,000             
      accrual of the end of term charge on the debt
    		                                      19,000 11,000 27,000 24,000 29,000 33,000 29,000 48,000 49,000                                             
      cash paid (received) for income taxes
    		                                                                                           
      amortization of debt discount and debt issuance costs
    		                                 30,000 31,000 175,000 37,000 38,000 114,000 123,000 106,000 91,000 90,000 102,000 20,000 118,000 118,000                                             
      accretion of backend fee on debt
    		                                                                                           
      stock based compensation expense
    		                                  4,032,000 5,045,000 4,615,000 4,219,000 3,796,000 3,439,000 4,522,000 3,256,000 2,978,000 2,358,000 1,457,000 3,999,000 954,000 1,463,000 505,000 518,000 495,000 508,000 439,000 485,000 167,000 151,000 86,000 64,000 65,000 117,000 503,000 483,000 1,439,000 345,000 207,000 165,000 133,000 294,000 98,000 73,000 56,000 204,000 200,000 211,000 270,000                 
      accrual of backend fee on debt
    		                                  171,000                                                         
      net (decrease) / increase in cash and cash equivalents
    		                                                                                           
      cash paid / (received) for income taxes
    		                                   23,000                                                        
      cash received for taxes
    		                                      0 0 994,000 0 0 4,389,000                                                
      accrued expenses and other current liabilities
    		                                      -321,000 160,000 1,723,000                                                   
      payments on capital lease obligations
    		                                               -29,000 -29,000 -28,000 -34,000 -18,000 -22,000 -21,000 -21,000                                     
      decrease in cash and cash equivalents
    		                                                    610,000                             -10,852,000 -4,619,000   -3,108,000 -2,221,000     
      gain on sale of asset
    		                                               0 0 0 -5,000         294,000 0 -13,000 -127,755,000                             
      accrued expenses and deferred rent
    		                                            2,459,000 -338,000 1,787,000 891,000                                            
      accrued lease expenses
    		                                               -66,000 -64,000 -65,000 -64,000                                         
      purchases of fixed assets
    		                                                                                           
      proceeds from sale of asset
    		                                            0 0 2,000 0 0                                           
      maturity of certificate of deposit
    		                                                                                           
      net cash (used in) / provided by investing activities
    		                                                                                           
      net proceeds from issuances of common stock
    		                                                                                           
      increase in cash and cash equivalents
    		                                               45,793,000 16,414,000 6,532,000 7,195,000    11,357,000 1,056,000 -1,629,000 -8,048,000 6,624,000 -13,846,000 -8,245,000 -92,457,000 125,143,000   -3,327,000 1,152,000 6,632,000 -3,346,000 10,223,000 -12,076,000 -10,877,000 -13,367,000 -10,851,000 40,372,000 -1,841,000 -7,779,000 -7,316,000 26,549,000 1,713,000    -2,663,000       -8,885,000 
      supplemental disclosures of non-cash investing and financing activities:
    		                                                                                           
      value of warrant exercised by converting the warrant into shares of common stock
    		                                            0                                               
      gain on sale of assets
    		                                                                                           
      accrued lease expense
    		                                                                                           
      maturity of a certifcate of deposit
    		                                                                                           
      sales of short-term investments
    		                                               64,414,000 -1,000 4,144,000 12,907,000 10,482,000 9,249,000 181,000 16,588,000 24,414,000 21,500,000 42,846,000 26,393,000                                 
      borrowings of long-term debt, net of issuance costs
    		                                                                                           
      net proceeds from issuance of common stock
    		                                                                                           
      unrealized gain on investments
    		                                                199,000 -30,000 216,000 -421,000 -246,000 303,000 -179,000                                     
      value of warrant granted in connection with debt financing
    		                                                                                           
      gain on sale of short-term investments
    		                                                                                           
      impairment loss
    		                                                   0                                        
      income tax receivable
    		                                                       59,000 -59,000                                   
      deferred revenue
    		                                                   -421,000 226,000 -49,000 -158,000 304,000 -340,000 -39,000 79,000                                 
      cash consideration for merger, net of cash acquired
    		                                                                                           
      purchases of short-term investments
    		                                                   424,000 -122,000 -1,376,000 -87,000 -7,705,000 -22,089,000 -52,899,000 -19,769,000 -14,098,000                                
      repayment of convertible notes
    		                                                       0 0 0 -231,000 -230,000 -231,000 -232,000 -553,000 -553,000 -552,000 -553,000 -553,000                         
      other
    		                                                       3,000 0   3,000 8,000 6,000 25,000 59,000 -5,000   55,000 0   184,000 6,000 107,000 28,000                 
      capital lease obligations incurred
    		                                                                                           
      unrealized (gain) loss on investments
    		                                                                                           
      accretion of beneficial conversion charge
    		                                                                                           
      fair value of warrant granted in connection with debt financing
    		                                                                                           
      conversion of series b preferred stock into common stock
    		                                                                                           
      issuance of common stock upon merger
    		                                                                                           
      issuance of preferred stock upon merger
    		                                                                                           
      amortization of financing costs
    		                                                                                           
      proceeds from issuance of debt, net of issuance and financing costs
    		                                                                                           
      supplemental disclosures of cash flow information
    		                                                                                           
      supplemental disclosures of non-cash investing and financing activities
    		                                                                                           
      fair value of warrants in connection with debt
    		                                                0                                           
      accrued expenses
    		                                                 1,687,000 -609,000 371,000 390,000 247,000 -341,000                                     
      proceeds from issuance of debt net of issuance and financing costs
    		                                                                                           
      restricted stock unit liability
    		                                                           0 0 0 -113,000                             
      asset retirement obligation
    		                                                           0 0 0 -2,217,000     148,000 148,000 148,000 147,000 148,000 148,000 148,000 148,000 147,000    189,000 117,000           
      interest payable
    		                                                       0 0 0 -1,000 -1,000 -1,000 -7,000 -3,000 -2,000 -3,000 -2,000 -3,000     -4,000 -1,000 0 -24,000 -54,000 -209,000 235,000 80,000             
      cash received from asset sale
    		                                                           -294,000 0 13,000 127,755,000                             
      warrants converted into shares
    		                                                           -2,000 0           259,000 0 0 8,810,000                 
      cash paid (received) for taxes
    		                                                                                           
      purchase of capital leases
    		                                                                                           
      adjustments to reconcile net income to net cash
    		                                                                                           
      provided by operating activities:
    		                                                                                           
      accretion of beneficial conversion feature
    		                                                    0 0 -9,175,000                                     
      see accompanying notes to unaudited consolidated financial statements
    		                                                                                           
      adjustments to reconcile net
    		                                                                                           
      prepaid expenses
    		                                                      108,000 127,000 -23,000 -259,000 77,000                                 
      used in provided by operating activities:
    		                                                                                           
      change in trading securities
    		                                                                                           
      realized loss on investments
    		                                                               0   392,000                         
      accrued project costs & other
    		                                                          46,000 -74,000 554,000 -125,000 -141,000                             
      payroll liabilities
    		                                                       300,000 95,000 161,000 -355,000 159,000 -614,000 -4,013,000 4,595,000 -180,000 -545,000 379,000 168,000 -653,000 41,000 -871,000 812,000 -850,000 462,000 764,000 -648,000 210,000 330,000 -373,000 224,000 234,000 411,000           
      income tax liability
    		                                                            -625,000 -1,544,000 2,794,000                             
      deferred rent
    		                                                           29,000 0 0 -65,000                             
      certificate of deposits
    		                                                             0 10,000                             
      supplemental information
    		                                                                                           
      used in operating activities:
    		                                                                                           
      stock options issued for services
    		                                                                0   -1,000 0 31,000 8,000 20,000 19,000 20,000 20,000 20,000                
      change in certificate of deposits
    		                                                           0                                
      decreases in short-term investments
    		                                                                                           
      deferred income
    		                                                            -39,000 38,000 -70,000 111,000 -634,000 554,000 26,000                         
      (increases) decreases in short-term investments
    		                                                                                           
      stock and stock options issued for services
    		                                                                                           
      impairment of property, plant & equipment
    		                                                                                           
      purchases of investments
    		                                                                   0 0 0 -500,000                     
      purchases of property, plant and equipment
    		                                                                                           
      public offering
    		                                                                   0 0                       
      issuance costs
    		                                                                   0 0   0 0 -105,000 -316,000                 
      total proceeds from issuance of common stock
    		                                                               59,000 -5,000   55,000 0   443,000 6,000 2,000 51,762,000                 
      accrued project costs
    		                                                                -356,000 520,000 12,000  188,000 -155,000 -547,000   1,350,000 -1,986,000 1,795,000 -103,000 -461,000 -125,000 117,000 -517,000 444,000 -907,000         
      decreases of short-term investments
    		                                                                4,571,000 -744,000 5,601,000                         
      loss on investments
    		                                                                                           
      costs incurred in conjunction with issuance of debt
    		                                                                           0 0 0 -2,428,000             
      cash restricted to restricted letters of credit
    		                                                                      297,000 0 0   0 0 0 185,000             
      non-cash stock acceleration
    		                                                                           0 1,000               
      impairment of property, plant and equipment
    		                                                                                           
      decreases (increases) of short-term investments
    		                                                                                           
      proceeds from issuance of convertible debt with detachable stock warrants
    		                                                                           0   35,000,000             
      changes in cash restricted to restricted letters of credit
    		                                                                   723,000 0                       
      cash and cash equivalents at beginning of year
    		                                                                                           
      cash and cash equivalents at end of year
    		                                                                                           
      public offering - issuance of 23 million shares
    		                                                                       0 0 0 43,240,000                 
      inventories
    		                                                                                           
      accrued project costs and other
    		                                                                       889,000            -353,000   -739,000    -1,396,000 
      restructuring reserve
    		                                                                        -84,000 -83,000 -82,000 -121,000 -80,000 -80,000 -78,000 -105,000 -78,000 -76,000 -76,000 -45,000 -84,000 -85,000 -84,000     
      purchases of property, plant & equipment
    		                                                                                           
      purchase of property, plant and equipment
    		                                                                                           
      decrease in cash restricted to restricted letters of credit
    		                                                                          288,000                 
      net income per share
    		                                                                          -130  -100 -60 -130    -120         
      pro-forma fair value stock compensation expense
    		                                                                          -560,000  426,000 -57,000 -560,000    -480,000         
      pro-forma net income
    		                                                                          -6,324,000  -4,806,000 -2,817,000 -6,324,000    -5,239,000         
      pro-forma net income per share
    		                                                                          -140  -90 -60 -140    -140         
      due from taisho pharmaceutical co., ltd.
    		                                                                                   0 0 0 199,000 1,534,000 533,000 1,393,000 -138,000 
      furniture and office equipment
    		                                                                                           
      accumulated depreciation
    		                                                                                           
      property and equipment
    		                                                                                           
      stock based employee compensation cost
    		                                                                                           
      asset retirement obligations
    		                                                                             148,000 148,000             
      proceeds from issuance of convertible debt
    		                                                                                           
      stock issued for services
    		                                                                               0     0       
      cash restricted to support letters of credit
    		                                                                                           
      cash in restricted letters of credit
    		                                                                                -6,000           
      amortization of goodwill
    		                                                                                           
      goodwill impairment charge
    		                                                                                           
      operational restructuring—non-cash
    		                                                                                           
      recognition of deferred revenues
    		                                                                                       0    
      (gain) loss on sale of marketable securities
    		                                                                                           
      issuance of stock for services
    		                                                                                           
      changes in operating assets and liabilities
    		                                                                                           
      proceeds from marketable securities matured and sold
    		                                                                                           
      purchases of property and equipment
    		                                                                                           
      operational restructuring
    		                                                                                       -586,000    
      initial license fee — taisho
    		                                                                                           
      non-cash stock compensation
    		                                                                                           
      purchased research and development
    		                                                                                           
      other current assets
    		                                                                                           
      purchases of marketable securities
    		                                                                                           
      acquisition of celtrix pharmaceuticals, inc., net of cash acquired
    		                                                                                           
      repayment of notes receivable from stock sales
    		                                                                                           
      decrease (increase) in cash and cash equivalents
    		                                                                                       -3,842,000    
      see accompanying notes.
    		                                                                                           
      gain on sale of marketable securities
    		                                                                                           
    The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.