7Baggers
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-09-30 2016-06-30 2016-03-31 2015-09-30 2015-06-30 2015-03-31 2014-09-30 2014-06-30 2014-03-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 2004-03-31 2003-12-31 2003-09-30 2003-06-30 2003-03-31 2002-12-31 2002-09-30 2002-06-30 2002-03-31 
      
    		                                                                                           
      assets
    		                                                                                           
      current assets:
    		                                                                                           
      cash and cash equivalents
    		334,764,000 1,284,324,000 403,247,000 555,030,000 461,451,000 1,246,799,000 595,729,000 482,374,000 487,113,000 612,882,000 968,907,000 1,074,036,000 414,633,000 416,078,000 515,704,000 716,782,000 846,556,000 928,327,000 409,751,000 532,756,000 588,753,000 641,911,000 428,942,000 487,429,000 535,632,000 601,260,000 420,231,000 495,072,000 567,574,000 634,329,000 686,581,000 381,165,000 430,678,000 91,064,000 125,839,000 200,518,000 223,109,000 252,872,000 310,969,000 335,027,000 134,554,000 167,311,000 82,697,000 101,251,000 128,025,000 74,588,000 79,434,000 90,782,000 44,989,000 28,575,000 22,043,000 14,848,000 10,449,000 9,839,000 22,100,000 10,743,000 9,687,000 11,316,000 19,364,000 12,740,000 26,838,000        18,913,000 22,259,000 12,036,000 24,112,000 34,989,000 48,356,000 59,207,000 18,835,000 20,676,000 28,455,000 35,771,000 9,222,000 7,509,000 14,055,000 24,907,000 29,526,000 32,189,000 22,008,000 25,116,000 27,337,000 31,179,000 36,265,000 42,365,000 
      marketable securities
    		1,345,222,000 572,441,000 796,204,000 878,796,000 1,006,457,000   298,073,000 298,838,000 304,886,000 29,774,000 74,244,000 98,662,000 138,790,000 119,415,000 50,043,000                                                                            
      accounts receivable
    		65,259,000 55,033,000 47,746,000 52,012,000 42,317,000 40,300,000 37,162,000 41,189,000 35,579,000 30,947,000 30,523,000 29,713,000 27,401,000 29,481,000 25,722,000 24,351,000 19,317,000 18,417,000 17,628,000 16,562,000 15,196,000 15,173,000 17,154,000 19,232,000 15,346,000 11,638,000 9,347,000 5,515,000                        757,000 440,000 303,000 169,000 471,000 178,000 190,000 189,000 245,000 319,000 211,000 114,000 122,000 72,000 50,000 327,000 250,000 25,000  111,000 241,000 250,000 105,000                  
      inventory
    		120,965,000 107,605,000 100,713,000 98,578,000 98,470,000 90,063,000 82,957,000 83,248,000 77,923,000 77,349,000 71,317,000 69,922,000 66,276,000 67,017,000 64,145,000 67,009,000 67,453,000 60,385,000 52,060,000 49,592,000 43,483,000 35,473,000 30,645,000 28,313,000 23,313,000 20,160,000 12,682,000 7,032,000                                                                
      prepaid expenses and other current assets
    		65,597,000 62,177,000 54,782,000 37,245,000 41,150,000 41,022,000 42,874,000 24,179,000 27,123,000 26,360,000 28,542,000 25,468,000 25,193,000 23,360,000 31,154,000 28,898,000 25,655,000 31,066,000 21,565,000 23,982,000 19,717,000 14,755,000 15,769,000 20,220,000 21,313,000 15,856,000 12,372,000 11,327,000 9,921,000 10,929,000 9,832,000 8,279,000 6,802,000 5,470,000 5,785,000 5,778,000 6,201,000 5,618,000 8,289,000 7,062,000 5,689,000 3,532,000 4,015,000 4,958,000 1,720,000 1,783,000 1,418,000 643,000 605,000 715,000 178,000 370,000                                        
      total current assets
    		1,931,807,000 2,081,580,000 1,402,692,000 1,621,661,000 1,649,845,000 1,418,184,000 758,722,000 929,063,000 926,576,000 1,052,424,000 1,129,063,000 1,273,383,000 632,165,000 674,726,000 756,140,000 837,040,000 958,981,000 1,038,195,000 501,004,000 622,892,000 667,149,000 707,312,000 492,510,000 555,194,000 595,604,000 648,914,000 454,632,000 518,946,000 577,495,000 645,258,000 696,413,000 389,444,000 437,480,000 96,534,000 131,624,000 206,296,000 229,310,000 258,490,000 319,258,000 342,089,000 140,243,000 170,843,000 86,712,000 106,209,000 129,745,000 78,566,000 83,025,000 93,578,000 90,353,000 73,850,000 70,960,000 77,399,000 83,983,000 92,619,000 103,062,000 108,797,000 124,893,000 125,319,000 124,805,000 124,608,000 122,537,000 123,202,000 127,684,000 2,593,000 5,961,000 9,690,000 12,467,000 16,973,000 19,669,000 22,963,000 12,675,000 25,423,000 37,484,000 50,733,000 59,525,000 19,203,000 21,093,000 28,930,000 36,156,000 9,681,000 8,274,000 15,526,000 25,291,000 29,751,000 32,534,000 22,474,000 25,243,000 28,151,000 33,772,000 38,981,000 46,199,000 
      fixed assets
    		89,671,000 89,995,000 88,358,000 80,052,000 75,265,000 72,777,000 68,660,000 65,384,000 64,630,000 62,113,000 59,556,000 56,491,000 53,684,000 53,946,000 52,676,000 52,955,000 53,199,000 53,784,000 52,684,000 53,953,000 55,314,000 56,826,000 58,638,000 60,180,000 52,991,000 38,913,000 27,933,000 22,636,000 19,526,000 17,881,000 15,816,000 12,432,000 8,975,000 9,234,000 9,807,000 10,274,000 9,793,000 8,899,000 8,052,000 7,989,000 7,292,000 5,982,000 4,778,000 1,977,000 1,904,000 1,855,000 1,681,000 1,666,000 1,647,000 1,758,000 1,867,000 1,937,000 1,424,000 1,016,000 1,042,000 1,102,000                                    
      finance lease right-of-use assets
    		16,239,000 16,917,000 17,595,000 18,273,000 18,951,000 19,629,000 20,307,000 20,985,000 21,663,000 22,341,000 23,019,000 23,697,000 16,697,000 17,178,000 17,814,000 9,256,000 9,525,000 9,795,000 10,064,000 10,334,000 10,603,000 14,536,000 14,896,000 15,256,000                                                                    
      operating lease right-of-use assets
    		10,708,000 10,315,000 10,832,000 17,257,000 16,030,000 16,406,000 17,157,000 18,017,000 18,441,000 16,476,000 21,154,000 21,894,000 22,430,000 24,047,000 31,277,000 33,305,000 31,283,000 32,037,000 34,279,000 32,946,000 32,505,000 31,901,000 36,137,000 37,673,000 39,949,000 42,316,000                                                                  
      intangibles
    		84,588,000 56,126,000 57,389,000 58,652,000 59,915,000 61,178,000 62,441,000 63,704,000 64,967,000 66,230,000 67,493,000 68,756,000 70,020,000 71,283,000 72,546,000 73,809,000 75,071,000 46,735,000 47,998,000 49,261,000 49,937,000 51,185,000 52,433,000 53,682,000 54,930,000 56,179,000 57,427,000 58,675,000                                                                
      goodwill
    		136,110,000 136,110,000 136,110,000 136,110,000 136,110,000 136,110,000 136,110,000 136,110,000 136,110,000 136,110,000 136,110,000 136,110,000 136,110,000 136,110,000 136,110,000 136,110,000 136,110,000                                     6,290,000 6,290,000 6,290,000                                 15,385,000 15,385,000 15,385,000 
      other assets
    		91,613,000 88,814,000 89,759,000 93,226,000 96,856,000 85,834,000 95,698,000 96,574,000 92,486,000 83,445,000 81,322,000 76,104,000 63,711,000 66,300,000 57,201,000 50,990,000 47,602,000 49,237,000 46,362,000 26,769,000 25,207,000 23,605,000 21,911,000 20,314,000 19,643,000 16,461,000 11,314,000 4,299,000 4,551,000 2,905,000 2,724,000 1,971,000 1,551,000 1,672,000 1,028,000 1,874,000 2,374,000 2,117,000 231,000 231,000 417,000 418,000 420,000 234,000 101,000 104,000 110,000 117,000                                            
      total assets
    		2,360,736,000 2,479,857,000 1,802,735,000 2,025,231,000 2,052,972,000 1,810,118,000 1,159,095,000 1,329,837,000 1,324,873,000 1,439,139,000 1,517,717,000 1,656,435,000 994,817,000 1,053,354,000 1,153,315,000 1,243,508,000 1,311,771,000 1,229,783,000 692,391,000 796,155,000 840,715,000 885,365,000 676,525,000 742,299,000 763,117,000 802,783,000 595,915,000 604,556,000 661,513,000 724,244,000 773,153,000 462,047,000 506,206,000 165,640,000 200,659,000 276,644,000 299,677,000 327,706,000 385,741,000 408,509,000 206,152,000 235,443,000 150,110,000 166,620,000 189,950,000 138,725,000 143,016,000 153,561,000 152,457,000 136,052,000 133,253,000 139,833,000 146,069,000 180,288,000 190,470,000 196,265,000 126,978,000 127,404,000 126,890,000 126,695,000 124,629,000 125,300,000 129,820,000 4,758,000 8,148,000 11,956,000 14,812,000 19,500,000 22,582,000 25,923,000 15,708,000 28,348,000 45,081,000 56,854,000 62,640,000 22,870,000 25,741,000 33,736,000 41,125,000 13,011,000 11,607,000 18,860,000 25,338,000 29,812,000 32,610,000 22,573,000 25,370,000 28,308,000 49,345,000 55,306,000 62,638,000 
      liabilities and shareholders’ equity
    		                                                                                           
      current liabilities:
    		                                                                                           
      accounts payable and accrued liabilities
    		409,835,000 305,019,000 232,674,000 285,209,000 248,684,000 290,844,000 189,362,000 214,987,000 187,783,000 197,653,000 179,005,000 182,117,000 131,861,000                                                                               
      finance lease liabilities
    		3,246,000 3,149,000 3,054,000 2,961,000 2,871,000 2,782,000 2,695,000 2,610,000 2,527,000 2,445,000 2,158,000 1,217,000 337,000 212,000 125,000 609,000 1,198,000 1,158,000 1,119,000 1,081,000 582,000 1,305,000 1,263,000 1,221,000                                                                    
      operating lease liabilities
    		4,133,000 3,513,000 3,505,000 9,358,000 7,633,000 6,077,000 4,609,000 8,032,000 6,418,000 4,159,000 6,821,000 6,909,000 5,456,000 5,037,000 9,625,000 9,527,000 5,952,000 5,925,000 6,418,000 11,475,000 9,741,000 7,499,000 10,367,000 11,040,000                                                                    
      total current liabilities
    		417,214,000 311,681,000 239,233,000 297,528,000 259,188,000 524,151,000 420,860,000 225,629,000 196,728,000 204,257,000 187,984,000 190,243,000 137,654,000 113,816,000 125,249,000 135,166,000 112,501,000 99,656,000 81,397,000 118,807,000 83,902,000 78,754,000 71,532,000 85,240,000 85,392,000 86,030,000 94,252,000 79,732,000 57,419,000 45,642,000 34,806,000 44,656,000 28,766,000 26,272,000 23,271,000 23,458,000 32,320,000 25,543,000 46,698,000 43,067,000 41,125,000 21,278,000 21,818,000 19,998,000 19,822,000 18,101,000 20,272,000 15,747,000 6,545,000 6,486,000 4,136,000 4,477,000 3,682,000 3,492,000 4,463,000 3,339,000    2,781,000 3,584,000 4,616,000 13,384,000 4,877,000 4,377,000 5,698,000 3,870,000 3,682,000 3,828,000 3,150,000 7,010,000 9,681,000 6,226,000 6,076,000 3,405,000 4,870,000 4,019,000 3,938,000 4,147,000 5,048,000 6,030,000 5,763,000 3,307,000 2,946,000 3,221,000 3,664,000 3,213,000 3,892,000 6,465,000 7,089,000 7,413,000 
      debt, long-term
    		539,719,000 538,508,000 1,105,068,000 1,103,382,000 954,831,000 946,825,000 939,081,000 1,155,313,000 1,147,519,000 1,139,805,000 1,132,188,000 1,125,250,000 784,799,000 783,977,000 783,156,000 566,588,000 557,604,000 548,745,000 361,575,000 356,318,000 351,127,000 346,001,000 340,939,000 335,940,000 331,003,000 326,128,000 321,313,000 316,558,000    55,567,000 55,388,000 55,194,000 54,993,000 34,681,000 16,136,000 19,114,000    14,713,000 16,494,000 14,569,000 12,538,000 14,894,000 14,511,000 16,221,000 8,503,000 8,965,000                                          
      royalty financing agreement
    		163,854,000 163,534,000 162,508,000 161,067,000 160,049,000 158,377,000 156,967,000 155,034,000 153,430,000 152,020,000 150,173,000 148,015,000                                                                                
      contingent consideration
    		259,600,000 180,500,000 159,900,000 144,200,000 157,600,000 101,500,000 63,700,000 84,600,000 69,900,000 46,400,000 38,600,000 51,100,000 51,800,000 55,600,000 66,120,000 75,668,000 76,490,000                                                                           
      finance lease liabilities, long-term
    		21,595,000 22,439,000 23,266,000 24,064,000 24,841,000 25,588,000 26,320,000 27,026,000 27,712,000 28,370,000 29,015,000 29,636,000 22,679,000 23,135,000 23,509,000 14,103,000 13,805,000 14,114,000 14,417,000 14,713,000 15,003,000 18,855,000 19,196,000 19,529,000                                                                    
      operating lease liabilities, long-term
    		7,588,000 7,899,000 8,480,000 9,112,000 9,692,000 11,666,000 13,809,000 11,013,000 13,023,000 12,871,000 14,534,000 14,853,000 16,504,000 18,201,000 19,875,000 21,441,000 22,647,000 23,409,000 24,068,000 21,255,000 23,198,000 25,099,000 27,197,000 29,308,000                                                                    
      other long-term liabilities
    		5,595,000 5,561,000 5,121,000 499,000 3,356,000 3,193,000 3,166,000 3,145,000 5,918,000 11,161,000 9,876,000 9,387,000 11,340,000 14,384,000 15,526,000 20,074,000 23,882,000 12,806,000 9,298,000 9,178,000 10,424,000 11,338,000 10,960,000 10,608,000 11,264,000 522,000 504,000  826,000 805,000 785,000 765,000 747,000 729,000 711,000 676,000 660,000 586,000 44,000 102,000 162,000                                                   
      total liabilities
    		1,415,165,000 1,230,122,000 1,703,576,000 1,739,852,000 1,569,557,000 1,771,300,000 1,623,903,000 1,661,760,000 1,614,230,000 1,594,884,000 1,562,370,000 1,568,484,000 1,024,776,000 1,009,113,000 1,033,435,000 833,040,000 806,929,000 698,730,000 490,755,000 520,271,000 483,654,000 480,047,000 469,824,000 480,625,000 459,076,000 446,210,000 451,778,000 396,290,000 370,106,000 353,603,000 338,297,000 100,988,000 84,901,000 82,195,000 78,975,000 58,815,000 49,116,000 45,243,000 46,742,000 43,169,000 41,287,000 36,176,000 38,562,000 34,882,000 32,825,000 33,541,000 35,411,000 32,679,000 15,845,000 16,336,000 5,119,000 5,566,000 3,727,000 3,550,000 4,666,000 3,422,000 2,292,000 3,018,000 2,463,000 2,781,000 3,584,000 4,616,000 13,384,000 7,581,000 7,414,000 9,261,000 7,822,000 8,012,000 8,158,000 7,645,000 12,017,000 14,468,000 11,328,000 10,953,000 8,061,000 12,341,000 19,453,000 24,618,000 23,576,000 5,776,000 6,700,000 6,394,000 3,877,000 3,592,000 3,959,000 4,486,000 4,120,000  7,417,000   
      shareholders’ equity:
    		                                                                                           
      common stock
    		2,126,000 2,111,000 1,819,000 1,794,000 1,788,000 1,667,000 1,486,000 1,480,000 1,430,000 1,428,000 1,364,000 1,357,000 1,217,000 1,199,000 1,193,000 1,187,000 1,184,000 1,152,000 1,033,000 1,028,000 1,018,000 1,014,000 899,000 897,000 893,000 892,000 776,000 773,000 771,000 770,000 766,000 766,000 766,000 624,000 621,000 619,000 619,000 619,000 618,000 617,000 500,000 496,000 393,000 393,000 391,000 320,000 316,000                                 449,000 384,000 384,000 384,000 384,000 384,000 332,000 332,000 332,000 331,000 331,000 330,000 
      additional paid-in capital
    		6,249,654,000 6,184,078,000 4,714,742,000 4,645,791,000 4,605,449,000 3,943,826,000 3,138,578,000 3,113,487,000 2,971,375,000 2,945,229,000 2,809,242,000 2,782,416,000 2,506,665,000 2,449,281,000 2,428,582,000 2,673,556,000 2,655,823,000 2,569,028,000 2,122,743,000 2,105,252,000 2,084,305,000 2,069,119,000 1,808,712,000 1,797,286,000 1,786,667,000 1,778,517,000 1,499,646,000 1,489,664,000 1,481,205,000 1,472,699,000 1,460,460,000 1,318,181,000 1,313,006,000 930,185,000 923,760,000 914,049,000 909,004,000 904,342,000 896,099,000 891,479,000 662,514,000 651,904,000 540,298,000 537,264,000 532,141,000 462,944,000 455,725,000 455,325,000 455,560,000 429,545,000 428,237,000 427,743,000 427,234,000 426,795,000 426,146,000 423,877,000 350,458,000 350,372,000 350,308,000 350,243,000 350,125,000 349,622,000 343,817,000 342,378,000 341,973,000 341,771,000  341,270,000 340,773,000 340,675,000 323,728,000 323,664,000 322,120,000 321,895,000 321,663,000                 
      accumulated deficit
    		-5,308,207,000 -4,938,186,000 -4,616,500,000 -4,359,917,000 -4,124,369,000 -3,903,845,000 -3,603,236,000 -3,446,145,000 -3,260,084,000 -3,101,151,000 -2,856,342,000 -2,696,578,000 -2,536,455,000 -2,405,310,000 -2,309,665,000 -2,265,243,000 -2,152,265,000 -2,039,551,000 -1,922,230,000 -1,830,589,000 -1,728,376,000 -1,664,717,000 -1,602,863,000 -1,536,499,000 -1,483,511,000 -1,422,829,000 -1,356,315,000 -1,282,162,000 -1,190,589,000 -1,102,846,000 -1,026,409,000 -957,885,000 -892,501,000               -335,548,000 -320,095,000 -310,714,000 -301,018,000 -294,174,000 -286,011,000 -251,422,000 -241,404,000 -234,510,000 -228,666,000 -228,336,000 -227,958,000 -228,076,000 -230,382,000 -230,232,000 -228,631,000 -346,426,000 -342,462,000 -340,299,000  -330,759,000 -327,465,000 -323,551,000 -321,050,000 -310,797,000 -289,369,000 -276,996,000 -268,085,000 -254,658,000 -241,773,000 -228,017,000 -219,493,000 -213,729,000 -207,892,000 -200,296,000 -191,285,000 -186,526,000 -184,075,000 -181,677,000 -178,437,000 -176,228,000 -157,731,000 -153,025,000 -145,918,000 
      accumulated other comprehensive gain
    		1,998,000 1,732,000                                                                                          
      total shareholders’ equity
    		945,571,000 1,249,735,000 99,159,000  483,415,000 38,818,000        44,241,000 119,880,000  504,842,000 531,053,000 201,636,000  357,061,000 405,318,000 206,701,000  304,041,000 356,573,000 144,137,000  291,407,000 370,641,000 434,856,000  421,305,000 83,445,000 121,684,000 217,829,000 250,561,000 282,463,000 338,999,000 365,340,000 164,865,000 199,267,000 111,548,000 131,738,000 157,125,000 105,184,000 107,605,000                                             
      total liabilities and shareholders’ equity
    		2,360,736,000 2,479,857,000 1,802,735,000  2,052,972,000 1,810,118,000   1,324,873,000 1,439,139,000 1,517,717,000  994,817,000 1,053,354,000 1,153,315,000  1,311,771,000 1,229,783,000 692,391,000  840,715,000 885,365,000 676,525,000  763,117,000 802,783,000 595,915,000  661,513,000 724,244,000 773,153,000  506,206,000 165,640,000 200,659,000 276,644,000 299,677,000 327,706,000 385,741,000 408,509,000 206,152,000 235,443,000 150,110,000 166,620,000 189,950,000 138,725,000 143,016,000                          45,081,000                   
      accumulated other comprehensive loss
    		  -902,000 -2,289,000  -2,830,000 -1,636,000               -98,000 -47,000 -10,000 -8,000 -7,000  -9,000    -3,000                                                            
      liabilities and shareholders' equity
    		                                                                                           
      shareholders' equity:
    		                                                                                           
      total shareholders' equity
    		   285,379,000        87,951,000    410,468,000    275,884,000    261,674,000    208,266,000    361,059,000                                                            
      total liabilities and shareholders' equity
    		   2,025,231,000    1,329,837,000    1,656,435,000    1,243,508,000    796,155,000    742,299,000    604,556,000    462,047,000                                                            
      accumulated other comprehensive income
    		    547,000   -745,000 -2,078,000 -1,251,000 1,083,000 756,000 -1,386,000 -929,000 -230,000 968,000 100,000 424,000 90,000 193,000 114,000      30,000  20,000 18,000 39,000  34,000    12,000                                                       
      current portion of long-term debt
    		     224,448,000 224,194,000                              8,689,000 5,674,000 25,256,000 25,123,000                                                    
      total shareholders’ deficit
    		      -464,808,000                                                                                     
      total liabilities and shareholders’ deficit
    		      1,159,095,000                                                                                     
      total shareholders' (deficit) equity
    		       -331,923,000                                                                                    
      total shareholders’ (deficit) equity
    		        -289,357,000 -155,745,000 -44,653,000  -29,959,000                                                                               
      marketable securities, non-current
    		             9,764,000                                                                              
      accounts payable
    		             31,144,000 48,571,000 35,784,000 23,531,000 31,081,000 22,422,000 42,853,000 22,147,000 25,005,000 18,188,000 13,184,000 20,415,000 17,031,000 30,223,000 17,741,000 16,579,000 15,966,000 13,176,000 14,671,000 9,348,000 11,030,000 8,454,000 8,283,000 9,402,000 8,688,000 10,857,000 8,681,000 7,860,000 8,867,000 11,407,000 9,818,000 4,661,000 7,865,000 8,184,000 7,060,000 2,985,000 3,198,000 2,879,000 2,334,000 1,504,000 1,921,000 3,082,000 1,450,000 431,000 912,000 433,000 312,000 581,000 711,000 2,667,000 1,277,000 1,117,000 1,088,000 804,000 904,000 736,000 681,000 4,251,000 7,187,000 3,784,000 2,884,000 2,243,000 968,000 1,994,000 1,931,000 1,541,000 2,621,000 3,980,000 3,607,000 1,774,000 660,000 638,000 1,542,000 1,145,000 941,000 2,706,000 3,197,000 3,241,000 
      accrued liabilities
    		             58,770,000 53,289,000 60,665,000 62,266,000                                                                           
      accrued compensation
    		             18,653,000 13,639,000 28,581,000 19,554,000 15,939,000 10,149,000 25,591,000 16,283,000 13,021,000 8,949,000 19,140,000 13,954,000 10,218,000 16,271,000 22,208,000            2,550,000 1,584,000 3,032,000 2,071,000 1,371,000 1,953,000 1,889,000 1,359,000 2,207,000 1,581,000 849,000 510,000 795,000                                        
      marketable securities, long-term
    		              29,551,000                                                                             
      accrued expenses
    		                 45,553,000 41,289,000 37,807,000 35,149,000 31,924,000 32,687,000 40,375,000 38,908,000 49,363,000 38,317,000 38,254,000 40,368,000 29,046,000 21,074,000 29,339,000 18,802,000 14,548,000 14,143,000 14,528,000 13,513,000 10,495,000 9,903,000 6,012,000 5,976,000 3,547,000 4,546,000 3,143,000 5,652,000 3,188,000 5,329,000 2,933,000 836,000 1,882,000 193,000 800,000 1,548,000 1,162,000 915,000                                     
      other current liabilities
    		                      78,000 280,000 130,000 234,000 82,000 1,529,000 472,000 630,000 556,000 646,000 616,000 694,000 674,000 647,000 716,000 686,000 682,000 701,000 716,000                                                   
      lease liabilities
    		                        11,985,000 9,184,000 9,359,000                                                                 
      long-term lease liabilities
    		                        31,417,000 33,530,000 35,709,000                                                                 
      right-of-use assets
    		                          44,609,000                                                                 
      intangible assets
    		                            59,941,000                                                               
      long-term debt
    		                            311,861,000 307,156,000 302,706,000                                                             
      in-process research and development
    		                             58,200,000 58,200,000 58,200,000 58,200,000 58,200,000 58,200,000 58,200,000 58,200,000 58,200,000 58,200,000 58,200,000 58,200,000 58,200,000 58,200,000 58,200,000 58,200,000 58,200,000 58,200,000 58,200,000 58,200,000 58,200,000 58,200,000 58,200,000 58,200,000 77,900,000 77,900,000 77,900,000                                    
      accumulated other comprehensive
    		                                                                                           
      current portion of long term debt
    		                                        24,989,000 5,178,000 3,281,000 5,187,000 7,055,000 4,650,000 4,875,000 3,007,000                                            
      accrued lease expense, current
    		                                         317,000 314,000 310,000 303,000 301,000 298,000 295,000 291,000 288,000 285,000 278,000                                        
      deferred rent
    		                                         321,000 167,000 121,000 134,000 139,000 144,000 149,000 151,000 152,000 154,000 156,000 154,000 150,000 150,000 150,000 132,000 132,000 132,000 132,000 103,000 103,000 103,000 168,000 115,000 115,000 115,000 115,000 54,000 54,000 54,000 54,000                    
      capital lease obligations, current
    		                                         16,000 32,000 48,000 64,000 69,000 83,000 96,000 109,000 117,000 115,000 114,000 55,000 64,000 72,000 81,000                                    
      accrued lease expense, long-term
    		                                         185,000 250,000 315,000 449,000 514,000 580,000 647,000 717,000 784,000 852,000 923,000                                        
      certificate of deposit
    		                                             2,195,000 2,173,000 2,153,000 2,132,000 2,111,000 2,091,000 2,085,000 2,085,000 2,085,000 2,176,000 2,176,000 2,085,000 2,085,000 2,085,000 2,085,000 2,085,000 2,085,000 2,085,000                             
      capital lease obligations, long-term
    		                                            16,000 32,000 48,000 64,000 80,000 101,000 131,000 166,000 45,000 58,000 71,000 83,000                                    
      warrant to purchase common stock
    		                                                                                           
      warrant to purchase 329,932 shares of common stock for 2.94 per share at march 31, 2013 and december 31, 2012
    		                                              790,000                                             
      short-term investments
    		                                                44,759,000 44,560,000 48,739,000 61,424,000 72,751,000 82,123,000 80,624,000 97,306,000 114,605,000 113,472,000 103,147,000 109,441,000 95,144,000                               
      liabilities and stockholders' equity
    		                                                                                           
      commitments and contingencies
    		                                                                                           
      stockholders' equity:
    		                                                                                           
      common stock; .01 par value; 500,000,000 authorized shares, 31,488,204 and 24,833,301 issued and outstanding shares at december 31, 2012 and 2011, respectively
    		                                               315,000                                            
      warrant to purchase 329,932 shares of common stock for 2.94 per share at december 31, 2012
    		                                               790,000                                            
      accumulated other comprehensive income:
    		                                                                                           
      unrealized gain on investments, net of taxes
    		                                                                                           
      total stockholders' equity
    		                                               120,882,000 136,612,000 119,716,000 128,134,000 134,267,000 142,342,000 176,738,000                                      
      total liabilities and stockholders' equity
    		                                               153,561,000 152,457,000 136,052,000 133,253,000 139,833,000 146,069,000 180,288,000 190,470,000 196,265,000 126,978,000 127,404,000 126,890,000 126,695,000 124,629,000 125,300,000 129,820,000 4,758,000 8,148,000       28,348,000                  55,306,000  
      other
    		                                                125,000 133,000                                          
      debt, current
    		                                                592,000                                           
      common stock; .01 par value; authorized shares 500,000,000; issued and outstanding shares, 31,178,954 in 2012 and 24,833,301 in 2011
    		                                                312,000                                           
      unrealized gain on investments
    		                                                835,000 636,000 666,000 450,000 871,000 1,117,000 814,000 993,000                                    
      common stock; .01 par value; authorized shares 500,000,000; issued and outstanding shares, 24,874,852 in 2012 and 24,833,301 in 2011
    		                                                 249,000 249,000                                         
      deposits
    		                                                  135,000 212,000 377,000 378,000                                      
      deferred revenue
    		                                                    421,000 195,000 244,000 402,000 98,000 438,000 477,000 398,000 231,000 270,000 232,000                           1,583,000 1,619,000 
      common stock; .01 par value; authorized shares 500,000,000; issued and outstanding shares, 24,833,301 in 2011 and 15,653,734 in 2010
    		                                                   248,000                                        
      preferred stock; .01 par value; authorized shares 200,000,000; issued and outstanding shares, zero in 2011 and 9,174,589 in 2010
    		                                                                                           
      prepaid expenses
    		                                                    343,000 354,000 169,000 277,000 364,000 341,000 82,000 159,000 236,000 145,000 30,000 74,000 118,000 193,000 110,000 244,000                        
      common stock; .01 par value; authorized shares
    		                                                                                           
      500,000,000; issued and outstanding shares, 24,833,301 in 2011 and 15,653,734 in 2010
    		                                                    248,000 248,000                                      
      preferred stock; .01 par value; authorized shares
    		                                                                                           
      200,000,000; issued and outstanding shares, zero in 2011 and 9,174,589 in 2010
    		                                                                                           
      see accompanying notes to unaudited consolidated financial statements
    		                                                                                           
      restricted stock units compensation liability
    		                                                      132,000                                     
      500,000,000; issued and outstanding shares, 24,828,101 in 2011 and 15,653,734 in 2010
    		                                                      248,000                                     
      income tax receivable
    		                                                        59,000  2,023,000 2,023,000                                
      long-term assets:
    		                                                                                           
      deferred financing costs
    		                                                           2,000 7,000 13,000 51,000 70,000 92,000 117,000 142,000 170,000 184,000 193,000 201,000 209,000 254,000 262,000 270,000 532,000 1,510,000 1,666,000 1,827,000             
      total long-term assets
    		                                                       87,468,000 2,085,000 2,085,000 2,085,000 2,087,000 2,092,000 2,098,000 2,136,000 2,165,000 2,187,000 2,266,000 2,345,000 2,527,000 2,913,000 2,960,000 3,033,000 2,925,000 7,597,000 6,121,000 3,115,000 3,667,000 4,648,000               
      accrued project costs & other
    		                                                       139,000 1,150,000 1,150,000 1,196,000 1,150,000 1,224,000 670,000 795,000 936,000 679,000 1,035,000 515,000 503,000 601,000 413,000 568,000 1,115,000 226,000 1,353,000 4,000 1,990,000                
      payroll liabilities
    		                                                       1,117,000 481,000 386,000 225,000 580,000 421,000 1,035,000 5,048,000 453,000 633,000 1,178,000 799,000 631,000 1,284,000 1,243,000 2,114,000 1,302,000 2,152,000 1,690,000 926,000 1,574,000 1,364,000 1,034,000 1,407,000 1,183,000 949,000 538,000 359,000 205,000 196,000 227,000 237,000 358,000 323,000 442,000 458,000 
      interest payable
    		                                                           1,000 2,000 3,000 10,000 13,000 15,000 18,000 20,000 23,000 23,000 23,000 23,000 23,000 27,000 28,000 28,000 52,000 106,000 315,000 80,000             
      convertible debt
    		                                                           231,000 461,000 692,000 2,211,000 2,211,000 2,211,000 2,211,000 2,211,000 2,211,000 1,708,000 1,139,000 5,125,000 5,125,000 6,013,000 6,013,000 6,013,000 11,438,000 24,176,000 35,000,000 35,000,000             
      debt discount
    		                                                           -23,000 -64,000 -118,000 -476,000 -596,000 -584,000 -784,000 -865,000 -950,000 -578,000 -403,000 -1,891,000 -1,964,000 -2,389,000 -2,466,000 -2,539,000 -5,001,000 -9,676,000 -15,186,000 -16,369,000             
      net convertible debt
    		                                                           208,000 397,000 574,000 1,735,000 1,615,000 1,627,000 1,427,000 1,346,000 1,261,000 1,130,000 736,000 3,234,000 3,161,000 3,624,000 3,547,000 3,474,000 6,437,000 14,500,000 19,814,000 18,631,000             
      long-term liabilities:
    		                                                                                           
      500,000,000; issued and outstanding shares, 15,653,734 in 2010 and 13,020,810 in 2009
    		                                                       1,565,000                                    
      200,000,000; issued and outstanding shares, 9,174,589 in 2010 and zero in 2009
    		                                                       918,000                                    
      net stockholders' equity
    		                                                       192,843,000 124,686,000 124,386,000 124,427,000 123,914,000 121,045,000 120,684,000 116,436,000 -2,823,000 734,000       13,880,000                  46,634,000  
      500,000,000; issued and outstanding shares, 130,345,819 in 2010 and 130,208,099 in 2009
    		                                                        1,303,000                                   
      unrealized gain on investment
    		                                                        1,591,000 1,047,000 775,000 445,000                                
      500,000,000; issued and outstanding shares, 130,295,819 in 2009 and 122,494,010 in 2008
    		                                                         1,303,000                                  
      common stock; .01 par value; authorized shares 500,000,000; issued and outstanding shares, 130,208,099 in 2009 and 122,494,010 in 2008
    		                                                          1,302,000 1,302,000 1,302,000                               
      accumulated other comprehensive gain:
    		                                                                                           
      restricted cash, long-term
    		                                                                                           
      restricted stock unit liability
    		                                                               113,000  12,000                          
      net long-term convertible debt
    		                                                               487,000 820,000 1,346,000 1,735,000 2,113,000 2,261,000 2,574,000                      
      asset retirement obligation
    		                                                               2,217,000 2,217,000 2,217,000 2,217,000 2,217,000 2,069,000 1,921,000 1,773,000 1,626,000 1,478,000 1,330,000 1,182,000 1,034,000 887,000 739,000 591,000 443,000 254,000 137,000          
      stockholders' equity
    		                                                                                           
      income taxes payable
    		                                                            625,000 1,250,000 2,794,000                             
      cash, cash equivalents and short-term investments
    		                                                             122,846,000 127,540,000 2,397,000 5,771,000 9,447,000 12,030,000 16,479,000                        
      common stock; .01 par value; authorized shares 500,000,000; issued and outstanding shares, 129,433,099 in 2009 and 122,494,010 in 2008
    		                                                             1,294,000                              
      common stock; .01 par value; authorized shares 500,000,000; issued and outstanding shares, 124,972,146 in 2009 and 122,494,010 in 2008
    		                                                              1,250,000                             
      restricted cash - long term
    		                                                               2,095,000 2,095,000 2,095,000 2,095,000   2,325,000 2,325,000 2,708,000 2,830,000 2,830,000 2,830,000  3,118,000 3,118,000 3,118,000             
      investments
    		                                                                 54,000 108,000 258,000 399,000 437,000 500,000                     
      property and equipment
    		                                                                   4,000 4,000 5,000 7,000 8,000  3,029,000 15,000 17,000 20,000 22,000 24,000 27,000 30,000 37,000 47,000 61,000 76,000 99,000 127,000 157,000 188,000 940,000 1,054,000 
      deferred income
    		                                                               302,000 191,000 825,000 271,000 245,000                        
      common stock; .01 par value; authorized shares 500,000,000; issued and outstanding shares, 122,494,010 in 2008 and 121,904,312 in 2007
    		                                                               1,225,000                            
      accumulated other comprehensive loss:
    		                                                                                           
      unrealized loss on investment
    		                                                                   -242,000 -101,000 -63,000                      
      common stock; .01 par value; authorized shares 500,000,000; issued and outstanding shares, 122,315,635 in 2008 and 121,904,312 in 2007
    		                                                                1,223,000                           
      liabilities and stockholders’ equity
    		                                                                                           
      stockholders’ equity:
    		                                                                                           
      common stock; .01 par value; authorized shares 500,000,000; issued and outstanding shares, 122,305,635 in 2008 and 121,904,312 in 2007
    		                                                                 1,223,000                          
      net stockholders’ equity
    		                                                                 2,695,000  11,488,000 14,424,000 18,278,000 3,691,000   45,901,000 54,579,000 10,529,000 6,288,000 9,118,000 17,549,000 7,235,000 4,907,000 12,466,000 21,461,000 26,220,000 28,651,000 18,087,000 21,250,000  41,928,000  53,606,000 
      total liabilities and stockholders’ equity
    		                                                                 11,956,000  19,500,000 22,582,000 25,923,000 15,708,000   56,854,000 62,640,000 22,870,000 25,741,000 33,736,000 41,125,000 13,011,000 11,607,000 18,860,000 25,338,000 29,812,000 32,610,000 22,573,000 25,370,000 28,308,000 49,345,000  62,638,000 
      restricted cash
    		                                                                    492,000 493,000 493,000 407,000 285,000 285,000 285,000 285,000 285,000 285,000 285,000 285,000 285,000 285,000          
      inventories
    		                                                                       576,000 1,821,000 1,797,000                  
      restricted cash—long term
    		                                                                   2,095,000        3,118,000                
      common stock; .01 par value; authorized shares 500,000,000; issued and outstanding shares, 121,904,312 in 2007 and 101,328,118 in 2006
    		                                                                   1,219,000                        
      other current assets
    		                                                                    239,000 211,000 35,000 87,000 139,000 190,000 33,000 83,000 132,000 190,000 100,000 174,000 480,000 1,186,000 384,000 225,000 345,000 466,000 127,000 615,000 860,000 450,000 175,000 
      restricted cash —long term
    		                                                                    2,326,000                       
      common stock; .01 par value; authorized shares 500,000,000; issued and outstanding shares, 121,708,316 in 2007 and 101,328,118 in 2006
    		                                                                    1,217,000 1,217,000                      
      common stock; .01 par value; authorized shares 500,000,000; issued and outstanding shares, 101,327,502 in 2007 and 101,328,118 in 2006
    		                                                                      1,013,000                     
      common stock; .01 par value; authorized shares 500,000,000; issued and outstanding shares, 101,328,118 in 2006 and 66,525,792 in 2005
    		                                                                       1,013,000                    
      property, plant and equipment
    		                                                                        4,513,000                   
      restructuring reserve
    		                                                                        37,000 121,000 204,000 286,000 360,000 360,000 360,000 360,000 334,000 334,000 334,000 334,000 287,000 287,000 287,000 310,000 921,000   
      common stock; .01 par value; authorized shares 500,000,000; issued and outstanding shares, 100,240,903 in 2006 and 66,525,792 in 2005
    		                                                                        1,002,000                   
      net shareholders’ equity
    		                                                                        33,753,000                   
      common stock; .01 par value; authorized shares 500,000,000; issued and outstanding shares, 100,228,903 in 2006 and 66,525,792 in 2005
    		                                                                         1,002,000                  
      common stock; .01 par value; authorized shares 500,000,000; issued and outstanding shares, 100,150,700 in 2006 and 66,525,792 in 2005
    		                                                                          1,001,000                 
      restructuring reserve-long-term portion
    		                                                                            47,000 127,000 207,000    570,000 646,000 738,000 822,000 907,000  952,000   
      common stock; .01 par value; authorized share 500,000,000; issued and outstanding shares, 66,525,792 in 2005 and 44,893,496 in 2004
    		                                                                           665,000                
      additional capital
    		                                                                           264,522,000 247,526,000 236,685,000 236,592,000 220,515,000 212,415,000 212,378,000 212,362,000 212,362,000 212,342,000 199,432,000 199,355,000 199,344,000 199,328,000 199,328,000 199,194,000 
      accrued project costs
    		                                                                            195,000 298,000 759,000 884,000 767,000 1,284,000 840,000 1,747,000 2,100,000 1,608,000  2,283,000    
      common stock; .01 par value; authorized share 500,000,000; issued and outstanding shares, 53,518,863 in 2005 and 38,409,643 in 2004
    		                                                                            535,000               
      common stock; .01 par value; authorized share 500,000,000; issued and outstanding shares, 45,090,629 in 2005 and 38,403,643 in 2004
    		                                                                             450,000              
      common stock; .01 par value; authorized share 500,000,000; issued and outstanding shares, 44,987,287 in 2005 and 44,893,496 in 2004
    		                                                                              450,000             
      restricted cash—long-term portion
    		                                                                               3,303,000            
      restructuring reserve—long-term portion
    		                                                                               285,000            
      restricted cash - long-term portion
    		                                                                                3,303,000 3,297,000          
      restructuring reserve - long-term portion
    		                                                                                416,000 494,000          
      due from taisho pharmaceutical co., ltd.
    		                                                                                       199,000 1,733,000 2,266,000 3,659,000 
      accrued project costs and other
    		                                                                                      1,544,000  2,515,000 3,307,000 3,571,000 
      deferred revenue — current portion
    		                                                                                           
      restructuring reserve — long-term portion
    		                                                                                       968,000    
      total stockholders’ equity
    		                                                                                       23,448,000    
      deferred revenue - current portion
    		                                                                                         143,000  
      see accompanying notes.
    		                                                                                           
      deferred revenue—current portion
    		                                                                                          143,000 
    The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.