7Baggers

Exact Sciences Quarterly Balance Sheets Chart

Quarterly
 | 
Annual
 
 Goodwill  
 Account Receivables  
 Cash and Cash Eq  
 Account Payables  
 Long-Term Debt  
 Short-Term Debt  
 Inventory  
20200930 20201231 20210331 20210630 20210930 20211231 20220331 20220630 20220930 20221231 20230331 20230630 20230930 20231231 20240331 20240630 20240930 20241231 20250331 20250630 00.340.681.011.351.692.032.37Billion

Exact Sciences Quarterly Balance Sheets Table

Quarterly
 | 
Annual
 
Unit: USD2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-09-30 2013-06-30 2013-03-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-09-30 2010-06-30 2010-03-31 2009-09-30 2009-06-30 2009-03-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 2004-03-31 2003-12-31 2003-09-30 2003-06-30 2003-03-31 2002-12-31 2002-09-30 2002-06-30 2002-03-31 2001-12-31 2001-09-30 2001-06-30 
                                                                                              
  assets                                                                                            
  current assets:                                                                                            
  cash and cash equivalents657,099,000 347,127,000 600,889,000 588,830,000 530,180,000 347,487,000 605,378,000 594,612,000 604,363,000 421,365,000 242,493,000 235,306,000 213,421,000 189,776,000 315,471,000 273,779,000 363,715,000 1,103,816,000 1,491,288,000 806,678,000 703,926,000 701,054,000 177,254,000 1,034,334,000 205,058,000 285,200,000 160,430,000 161,705,000 225,662,000 148,695,000 77,491,000 50,837,000 180,407,000 39,206,000 48,921,000 63,445,000 49,010,000 52,151,000 41,135,000 31,522,000 33,765,000 40,679,000 58,131,000 27,829,000 20,708,000 17,806,000 9,710,000 21,518,000 8,053,000 12,660,000 6,026,000 12,292,000  4,995,000 38,264,000 72,073,000 20,815,000 24,232,000 18,171,000 22,779,000 12,288,000 3,595,000 6,069,000 5,504,000 3,999,000  7,164,000 3,835,000 3,851,000 4,831,000 7,991,000 13,832,000 10,391,000 13,007 17,124,000 17,625,000 9,333,000 24,179,000 16,553,000 13,845,000 24,179,000  16,105,000 14,736,000 11,783,000  24,415,727 57,959,942 50,195,303  62,636,543 67,232,921 
  marketable securities201,336,000 439,048,000 437,137,000 432,301,000 416,602,000 304,606,000 172,266,000 139,794,000 171,349,000 277,282,000 389,564,000 433,808,000 514,623,000 627,204,000 715,005,000 944,688,000 943,864,000 274,151,000 348,699,000 476,324,000 518,731,000 530,062,000 146,401,000 126,211,000 1,034,364,000 997,506,000 963,752,000 1,023,512,000 996,500,000 893,474,000 347,224,000 411,684,000 303,853,000 235,464,000 262,179,000 274,385,000 175,067,000 210,441,000 265,744,000 311,987,000 177,053,000 204,472,000 224,625,000 183,315,000 214,089,000 98,204,000 138,131,000 136,211,000 87,429,000 105,912,000 64,839,000 71,244,000  70,436,000 45,204,000 17,660,000 14,026,000 13,092,000 4,221,000 4,165,000 15,510,000 17,018,000  2,244,000 5,488,000  7,611,000 13,108,000 14,708,000 16,244,000 16,384,000 13,208,000 19,395,000 21,112 20,101,000 22,916,000 35,001,000 41,190,000 38,604,000 46,253,000 41,190,000  19,221,000 12,386,000 23,302,000        
  accounts receivable353,335,000 279,800,000 248,968,000 264,819,000 263,865,000 240,584,000 203,623,000 199,403,000 178,317,000 183,371,000 158,043,000 189,206,000 186,542,000 205,625,000 216,645,000 249,572,000 226,539,000 256,135,000 233,185,000 206,606,000 163,608,000 140,046,000 130,667,000 82,200,000 63,903,000 56,095,000 44,239,000 41,916,000 36,268,000 34,575,000 26,419,000 24,553,000 22,591,000 16,214,000 8,526,000 7,863,000 7,441,000 5,621,000 4,933,000 4,209,000 2,151,000 1,581,000 1,376,000                                                  
  inventory171,499,000 176,574,000 162,383,000 136,987,000 127,373,000 128,534,000 127,475,000 132,841,000 130,770,000 124,092,000 118,259,000 114,699,000 115,172,000 112,958,000 104,994,000 95,167,000 89,809,000 89,033,000 92,265,000 80,427,000 82,215,000 69,424,000 61,724,000 53,673,000 47,781,000 44,269,000 39,148,000 38,617,000 35,409,000 32,380,000 26,027,000 18,064,000 12,410,000 7,859,000 6,833,000 7,666,000 8,404,000 8,157,000 6,677,000 6,032,000 6,275,000 5,423,000 4,017,000 2,719,000                                                 
  prepaid expenses and other current assets124,590,000 127,792,000 122,046,000 110,180,000 114,467,000 99,059,000 85,627,000 81,536,000 89,129,000 85,274,000 73,898,000 75,487,000 71,875,000 79,575,000 74,122,000 52,385,000 45,284,000 52,167,000 33,157,000 36,592,000 36,378,000 43,732,000 40,913,000 23,560,000 23,690,000 24,050,000 20,498,000 23,832,000 16,465,000 12,867,000 10,055,000 8,551,000 6,872,000 7,443,000 7,114,000 5,673,000 7,295,000 7,722,000 7,641,000 5,602,000 4,019,000 3,892,000 3,528,000 2,377,000 3,987,000 2,842,000 904,000 1,087,000 1,067,000 1,252,000 2,347,000 1,918,000  867,000 611,000 468,000 339,000 533,000 606,000 405,000 426,000 690,000 255,000 402,000 453,000  281,000 356,000 540,000 386,000 517,000 895,000 1,213,000 1,158 1,216,000 1,945,000 2,112,000                
  total current assets1,507,859,000 1,370,341,000 1,571,423,000 1,533,117,000 1,452,487,000 1,120,270,000 1,194,369,000 1,148,186,000 1,173,928,000 1,091,384,000 982,257,000 1,048,506,000 1,101,633,000 1,215,138,000 1,426,237,000 1,615,591,000 1,669,211,000 1,775,302,000 2,198,594,000 1,606,627,000 1,504,858,000 1,484,318,000 556,959,000 1,319,978,000 1,374,796,000 1,407,120,000 1,228,067,000 1,289,582,000 1,310,304,000 1,121,991,000 487,216,000 513,689,000 526,133,000 306,186,000 333,573,000 359,032,000 247,217,000 284,092,000 326,130,000 359,352,000 223,263,000 256,047,000 291,677,000 216,240,000 238,784,000 118,852,000 148,745,000 158,816,000 96,549,000 119,824,000 73,212,000 85,454,000  76,298,000 84,079,000 90,201,000 35,180,000 38,357,000 23,498,000 27,349,000 28,224,000 21,303,000 6,324,000 8,150,000 9,940,000  15,056,000 17,299,000 19,099,000 21,461,000 24,892,000 27,935,000 30,999,000 35,277 38,441,000 42,486,000 46,446,000 67,233,000 56,918,000 62,121,000 67,233,000  36,763,000 28,576,000 36,890,000  52,328,977 59,143,088 51,465,636  63,844,356 67,658,848 
  long-term assets:                                                                                            
  property, plant and equipment705,105,000 697,907,000 693,673,000 690,332,000 703,083,000 702,041,000 698,354,000 692,404,000 686,602,000 684,574,000 684,756,000 670,506,000 663,653,000 622,613,000 580,248,000 524,200,000 501,908,000 482,736,000 450,683,000 456,455,000 463,437,000 465,476,000 455,325,000 370,532,000 335,499,000 291,629,000 245,259,000 188,486,000 140,467,000 103,448,000                                                               
  operating lease right-of-use assets126,106,000 126,659,000 116,952,000 122,452,000 139,807,000 142,017,000 143,708,000 149,671,000 148,690,000 156,782,000 167,003,000 175,945,000 182,494,000 170,373,000 174,225,000 167,911,000 166,914,000 161,687,000 125,947,000 129,837,000 132,751,000 124,369,000 126,444,000                                                                      
  goodwill2,368,021,000 2,367,111,000 2,366,676,000 2,367,450,000 2,366,972,000 2,367,052,000 2,367,120,000 2,366,514,000 2,346,248,000 2,346,235,000 2,346,040,000 2,345,180,000 2,345,922,000 2,335,172,000 2,335,172,000 2,242,535,000 2,242,535,000 2,183,915,000 1,237,672,000 1,237,672,000 1,237,672,000 1,237,161,000 1,203,197,000                                                                      
  intangible assets965,370,000 988,873,000 1,009,693,000 1,864,399,000 1,843,478,000 1,866,856,000 1,890,396,000 1,913,307,000 1,910,559,000 1,933,481,000 1,956,240,000 1,977,690,000 2,046,773,000 2,069,757,000 2,094,411,000 2,044,958,000 2,089,108,000 2,073,932,000 848,426,000 871,660,000 1,105,115,000 1,128,261,000                                                                       
  other long-term assets124,904,000 160,182,000 169,722,000 170,821,000 167,468,000 178,085,000 177,387,000 150,748,000 89,536,000 91,872,000 90,577,000 88,739,000 96,680,000 77,484,000 74,591,000 59,241,000 54,658,000 56,945,000 63,770,000 52,119,000 23,902,000 21,540,000 20,293,000 24,373,000 26,602,000 26,189,000 4,415,000 9,015,000 8,773,000 9,919,000 9,198,000 17,784,000 14,420,000 5,680,000 5,325,000 5,706,000 5,079,000 4,650,000 4,070,000 2,562,000 2,442,000 1,200,000                                                   
  total assets5,797,365,000 5,711,073,000 5,928,139,000 6,748,571,000 6,673,295,000 6,376,321,000 6,471,334,000 6,420,830,000 6,355,563,000 6,304,328,000 6,226,873,000 6,306,566,000 6,437,155,000 6,490,537,000 6,684,884,000 6,654,436,000 6,724,334,000 6,734,517,000 4,925,092,000 4,354,370,000 4,467,735,000 4,461,125,000 3,505,768,000 1,759,268,000 1,781,943,000 1,770,548,000 1,524,022,000 1,509,576,000 1,482,652,000 1,256,916,000 598,560,000 587,179,000 582,601,000 350,261,000 377,040,000 403,211,000 288,529,000 323,788,000 364,296,000 393,989,000 253,017,000 278,814,000 311,624,000                                                  
  liabilities and stockholders’ equity                                                                                            
  current liabilities:                                                                                            
  accounts payable157,324,000 142,175,000 89,572,000 97,653,000 52,980,000 60,498,000 78,816,000 73,558,000 75,080,000 86,713,000 74,916,000 63,583,000 84,167,000 66,471,000 67,829,000 41,717,000 36,592,000 34,704,000 35,709,000 26,061,000 30,998,000 38,048,000 25,973,000 19,158,000 19,896,000 17,552,000 28,141,000 32,738,000 10,992,000 12,274,000 16,135,000 8,774,000 2,237,000 891,000 710,000 2,335,000 3,135,000 2,841,000 3,308,000 1,503,000 1,345,000 2,001,000 2,647,000 4,635,000 357,000 1,331,000 605,000 1,084,000 2,081,000 1,030,000 767,000 949,000  977,000 1,086,000 820,000 379,000 561,000 289,000 203,000 284,000 34,000 236,000 350,000 275,000  266,000 163,000 139,000 158,000 330,000 233,000 266,000 468 273,000 339,000 99,000 786,000 176,000 579,000 786,000  757,000 688,000 1,387,000  1,047,060 1,427,851 1,531,212  771,133 479,691 
  accrued liabilities317,154,000 295,137,000 328,292,000 313,997,000 302,540,000 265,121,000 341,683,000 309,872,000 299,586,000 241,844,000 299,216,000 307,990,000 308,219,000 365,916,000 398,556,000 304,714,000 265,997,000 214,143,000 233,604,000 182,945,000 139,505,000 166,596,000 193,329,000 134,832,000 151,009,000 143,129,000 100,644,000 68,938,000 60,046,000 56,716,000 49,126,000 38,390,000 26,935,000 27,077,000 28,106,000 26,104,000 23,808,000 20,477,000 22,253,000 20,929,000 16,306,000 11,652,000 13,960,000                                                  
  operating lease liabilities, current portion31,338,000 29,808,000 27,405,000 27,170,000 27,096,000 27,225,000 29,379,000 30,389,000 29,872,000 30,014,000 28,366,000 27,054,000 25,813,000 19,711,000 19,710,000 19,220,000 16,599,000 15,290,000 11,483,000 10,746,000 9,871,000 8,663,000 7,891,000                                                                      
  convertible notes, net, current portion  249,153,000 249,038,000 248,923,000 248,810,000          313,104,000 312,961,000 312,832,000 255,464,000     315,643,000 311,598,000                                                                    
  other current liabilities16,117,000 35,345,000 37,765,000 35,804,000 37,103,000 33,455,000 14,823,000 12,694,000 33,519,000 8,783,000 10,249,000 25,049,000 25,132,000 28,854,000 30,973,000 30,157,000 42,230,000 50,626,000 38,265,000 31,761,000 40,581,000 5,709,000 8,467,000                                                                      
  total current liabilities521,933,000 502,465,000 732,187,000 723,662,000 668,642,000 685,109,000 514,701,000 476,513,000 488,057,000 367,354,000 412,747,000 423,676,000 443,331,000 480,952,000 517,068,000 710,231,000 675,698,000 628,914,000 575,844,000 252,832,000 222,274,000 243,581,000 236,494,000 480,692,000 492,463,000 167,657,000 136,590,000 106,735,000 82,962,000 73,330,000 68,124,000 49,689,000 31,293,000 29,937,000 30,692,000 30,061,000 28,395,000 24,678,000 26,723,000 23,514,000 18,730,000 14,476,000 17,521,000 16,752,000 9,818,000 9,033,000 8,502,000 8,019,000 9,165,000 9,612,000 8,639,000 7,692,000  7,386,000 7,066,000 6,383,000 7,538,000 7,584,000 7,410,000 7,347,000 7,355,000 7,254,000 6,106,000 5,268,000 5,230,000  3,842,000 3,464,000 6,273,000 6,365,000 6,086,000 6,257,000 5,977,000 6,316 6,083,000 6,127,000 5,919,000 7,197,000 6,711,000 7,050,000 7,197,000  7,806,000 4,698,000 4,908,000  5,979,145 6,033,899 4,721,732  2,917,084 1,811,019 
  long-term liabilities:                                                                                            
  convertible notes, net, less current portion2,324,097,000 2,322,574,000 2,321,067,000 2,319,490,000 2,317,948,000 2,066,805,000         2,180,232,000 1,865,647,000 1,864,312,000 1,862,992,000 1,320,760,000                                                                          
  other long-term liabilities315,899,000 320,225,000 315,503,000 332,213,000 326,678,000 329,384,000 335,982,000 341,771,000 330,816,000 344,380,000 352,459,000 354,998,000 364,107,000 389,062,000 417,782,000 436,580,000 439,175,000 414,195,000 61,582,000 62,821,000 50,311,000 47,252,000 34,911,000 29,511,000 29,924,000 6,821,000 9,475,000 12,691,000 6,501,000 5,643,000 5,633,000 5,611,000 5,684,000 5,680,000 5,734,000 5,308,000 5,054,000 4,893,000 4,804,000 4,455,000 4,620,000 3,541,000 2,399,000                                                  
  operating lease liabilities, less current portion166,022,000 168,902,000 157,133,000 162,695,000 167,665,000 162,405,000 161,070,000 168,398,000 168,501,000 174,690,000 182,399,000 184,633,000 187,226,000 180,632,000 182,166,000 162,950,000 164,308,000 157,380,000 121,075,000 124,007,000 126,630,000 118,333,000 118,665,000                                                                      
  total liabilities3,327,951,000 3,314,166,000 3,525,890,000 3,538,060,000 3,480,933,000 3,243,703,000 3,326,029,000 3,299,603,000 3,298,941,000 3,246,620,000 3,183,711,000 3,197,932,000 3,227,809,000 3,232,326,000 3,297,248,000 3,196,846,000 3,165,233,000 3,085,522,000 2,101,603,000 2,017,270,000 1,956,542,000 1,923,472,000 1,217,707,000 1,010,984,000 1,016,411,000 993,608,000 843,081,000 792,847,000 738,264,000 569,898,000 78,142,000 60,035,000 41,907,000 40,741,000 41,745,000 40,882,000 39,141,000 35,455,000 37,440,000 32,703,000 28,176,000 20,605,000 22,640,000                                                  
  commitments and contingencies                                                                                            
  stockholders’ equity:                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000; shares issued and outstanding—no shares at june 30, 2025 and december 31, 2024                                                                                            
  common stock1,893,000 1,887,000 1,857,000 1,852,000 1,848,000 1,839,000 1,815,000 1,809,000 1,806,000 1,799,000 1,780,000 1,774,000 1,769,000 1,757,000 1,738,000 1,723,000 1,720,000 1,714,000 1,595,000 1,505,000 1,501,000 1,495,000 1,477,000 1,299,000 1,295,000 1,292,000 1,232,000 1,229,000 1,226,000 1,219,000 1,205,000 1,196,000 1,190,000 1,112,000 1,102,000 1,084,000 983,000 978,000 968,000 964,000 891,000 889,000 887,000 832,000 829,000 713,000 709,000 707,000 641,000      525,000     355,000 353,000 308,000 273,000 273,000             263,000 262,000 263,000 262,000 262,000  193,000 191,000 191,000  190,617 190,272 188,173  187,808 186,914 
  additional paid-in capital7,064,867,000 6,993,254,000 6,899,368,000 6,837,476,000 6,786,668,000 6,710,681,000 6,611,237,000 6,540,362,000 6,475,742,000 6,396,805,000 6,311,644,000 6,255,211,000 6,204,742,000 6,085,558,000 6,028,861,000 5,876,644,000 5,811,286,000 5,723,977,000 4,789,657,000 3,865,990,000 3,819,798,000 3,763,328,000 3,406,440,000 1,945,046,000 1,919,719,000 1,894,116,000 1,716,894,000 1,698,695,000 1,681,465,000 1,588,173,000 1,380,577,000 1,365,112,000 1,351,836,000 1,090,002,000 1,080,432,000 1,070,083,000 919,270,000 913,455,000 904,931,000 898,786,000 719,635,000 713,858,000 709,019,000 602,642,000 598,255,000 457,776,000 452,836,000 450,269,000 373,520,000 370,184,000 310,703,000 307,740,000  276,033,000 274,525,000 273,275,000 206,993,000 206,330,000 188,096,000 186,725,000 185,372,000 174,878,000 169,673,000 169,407,000 169,083,000  168,263,000 166,877,000 166,079,000 165,545,000 165,013,000 164,096,000 163,418,000 162,349 162,310,000 162,340,000 161,679,000 161,244,000 161,352,000 161,191,000 161,244,000  118,415,000 117,549,000 117,405,000  117,443,162 117,167,748 110,598,051  110,270,897 110,966,428 
  accumulated other comprehensive income3,086,000 1,013,000 -944,000 4,630,000 -943,000 -499,000 1,428,000        -1,443,000 133,000 67,000 364,000 526,000 1,084,000 1,489,000    1,760,000 354,000              155,000 -11,000 70,000 -115,000  89,000 133,000               38,000                                
  accumulated deficit-4,600,432,000 -4,599,247,000 -4,498,032,000 -3,633,447,000 -3,595,211,000 -3,579,403,000 -3,469,175,000 -3,419,409,000 -3,420,203,000 -3,339,177,000 -3,265,026,000 -3,137,281,000 -2,988,520,000 -2,822,457,000 -2,641,520,000 -2,420,910,000 -2,253,972,000 -2,077,060,000 -1,968,289,000 -1,531,479,000 -1,311,595,000 -1,225,453,000 -1,119,756,000 -1,197,701,000 -1,157,242,000 -1,118,822,000 -1,035,763,000 -981,789,000 -936,425,000 -900,038,000 -860,614,000 -838,850,000 -811,953,000 -781,163,000 -745,821,000 -708,651,000 -670,848,000 -626,083,000 -578,610,000 -538,619,000 -495,674,000 -456,608,000 -420,807,000                           -150,765,000    -137,850                   
  total stockholders’ equity2,469,414,000 2,396,907,000 2,402,249,000 3,210,511,000 3,192,362,000 3,132,618,000 3,145,305,000 3,121,227,000 3,056,622,000 3,057,708,000 3,043,162,000 3,108,634,000 3,209,346,000 3,258,211,000 3,387,636,000 3,457,590,000 3,559,101,000 3,648,995,000 2,823,489,000 2,337,100,000 2,511,193,000 2,537,653,000 2,288,061,000 748,284,000 765,532,000 776,940,000 680,941,000 716,729,000 744,388,000 687,018,000 520,418,000 527,144,000 540,694,000 309,520,000 335,295,000 362,329,000 249,388,000 288,333,000 326,856,000 361,286,000 224,841,000 258,209,000 288,984,000 215,105,000 242,870,000 121,756,000 145,090,000 153,580,000 89,133,000 110,657,000 64,024,000 75,863,000  64,592,000 70,891,000 76,278,000 17,801,000 20,535,000 4,737,000     2,242,000 4,041,000  9,746,000 12,552,000 13,571,000 14,958,000 16,850,000 18,990,000 21,540,000 24,621 27,264,000 30,552,000 33,754,000 50,556,000 42,429,000 46,504,000 50,556,000  17,817,000 23,588,000 30,994,000  44,832,530 51,435,184 52,200,181  64,541,394 69,264,905 
  total liabilities and stockholders’ equity5,797,365,000 5,711,073,000 5,928,139,000 6,748,571,000 6,673,295,000 6,376,321,000 6,471,334,000 6,420,830,000 6,355,563,000 6,304,328,000 6,226,873,000 6,306,566,000 6,437,155,000 6,490,537,000 6,684,884,000 6,654,436,000 6,724,334,000 6,734,517,000 4,925,092,000 4,354,370,000 4,467,735,000 4,461,125,000 3,505,768,000 1,759,268,000 1,781,943,000 1,770,548,000 1,524,022,000 1,509,576,000 1,482,652,000 1,256,916,000 598,560,000 587,179,000 582,601,000 350,261,000 377,040,000 403,211,000 288,529,000 323,788,000 364,296,000 393,989,000 253,017,000 278,814,000 311,624,000                                                  
  preferred stock, 0.01 par value authorized—5,000,000; shares issued and outstanding—no shares at march 31, 2025 and december 31, 2024                                                                                            
  debt, current portion     50,000,000 50,000,000 50,000,000 50,000,000       1,319,000 1,319,000 1,319,000 1,319,000 1,319,000 1,319,000 24,565,000 834,000 601,000 415,000 21,000 8,000  4,588,000 183,000 182,000 180,000 178,000 176,000                                                           
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at december 31, 2024 and december 31, 2023                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000; shares issued and outstanding—no shares at september 30, 2024 and december 31, 2023                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000; shares issued and outstanding—no shares at june 30, 2024 and december 31, 2023                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000; shares issued and outstanding—no shares at march 31, 2024 and december 31, 2023                                                                                            
  convertible notes      2,314,276,000 2,312,921,000 2,311,567,000 2,310,196,000 2,186,106,000 2,184,625,000 2,183,145,000 2,181,680,000      1,554,967,000 1,534,383,000 1,514,306,000 803,605,000   770,510,000 664,749,000 656,341,000 647,923,000 486,688,000                                                               
  long-term debt, less current portion               21,438,000 21,740,000 22,041,000 22,342,000 22,643,000 22,944,000  24,032,000 24,254,000 24,429,000 24,787,000 24,073,000 17,080,000 878,000                                                                
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at december 31, 2023 and december 31, 2022                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000; shares issued and outstanding—no shares at september 30, 2023 and december 31, 2022                                                                                            
  accumulated other comprehensive loss       -1,535,000 -723,000 -1,719,000 -5,236,000 -11,070,000 -8,645,000 -6,647,000        -1,717,000 -100,000 -360,000   -1,422,000 -1,406,000 -1,878,000 -2,336,000 -750,000 -314,000 -379,000 -431,000 -418,000 -187,000 -17,000 -17,000 -433,000                                                      
  preferred stock, 0.01 par value authorized—5,000,000; shares issued and outstanding—no shares at june 30, 2023 and december 31, 2022                                                                                            
  long-term debt         50,000,000 50,000,000 50,000,000 50,000,000                 4,237,000 4,269,000 4,511,000 4,552,000 4,592,000 4,633,000 4,673,000 4,711,000 4,750,000 4,852,000 3,535,000 3,488,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000  1,000,000                                       
  preferred stock, 0.01 par value authorized—5,000,000; shares issued and outstanding—no shares at march 31, 2023 and december 31, 2022                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at december 31, 2022 and december 31, 2021                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at september 30, 2022 and december 31, 2021                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at june 30, 2022 and december 31, 2021                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at march 31, 2022 and december 31, 2021                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at december 31, 2021 and december 31, 2020                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at september 30, 2021 and december 31, 2020                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at june 30, 2021 and december 31, 2020                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at march 31, 2021 and december 31, 2020                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at december 31, 2020 and december 31, 2019                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at september 30, 2020 and december 31, 2019                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at june 30, 2020 and december 31, 2019                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at march 31, 2020 and december 31, 2019                                                                                            
  intangibles                      1,143,550,000     22,493,000 23,108,000 21,558,000 22,160,000                                                              
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at december 31, 2019 and december 31, 2018                                                                                            
  goodwill and intangibles                       44,385,000 45,046,000 45,610,000 46,281,000                                                                  
  accrued interest                       1,168,000 2,870,000 1,066,000 4,593,000 1,901,000 4,154,000 1,407,000                                                               
  other short-term liabilities                       9,290,000 6,675,000 5,889,000 3,204,000 3,158,000 3,182,000 2,750,000 2,681,000 2,345,000 1,943,000 1,793,000 1,702,000 1,450,000 1,281,000 1,191,000 996,000 861,000 734,000                                                    
  long-term convertible notes, net, less current portion                       476,527,000 469,595,000                                                                    
  ​                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at september 30, 2019 and december 31, 2018                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at june 30, 2019 and december 31, 2018                                                                                            
  long-term obligations                         23,833,000                                                                   
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at march 31, 2019 and december 31, 2018                                                                                            
  lease incentive obligation, less current portion                          8,194,000    116,000 224,000 378,000 532,000 686,000 840,000 981,000 1,134,000 1,061,000 1,199,000 1,338,000 1,476,000 1,614,000 1,710,000 1,845,000 1,980,000 376,000                                              
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at december 31, 2018 and december 31, 2017                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at september 30, 2018 and december 31, 2017                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at june 30, 2018 and december 31, 2017                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at march 31, 2018 and december 31, 2017                                                                                            
  property and equipment, at cost:                                                                                            
  computer equipment and computer software                              30,148,000 27,374,000 24,802,000 22,485,000 20,767,000 19,053,000 17,514,000 15,827,000 14,025,000 12,662,000 10,807,000 8,818,000 7,577,000                                                  
  laboratory equipment                              23,296,000 20,352,000 18,258,000 15,837,000 14,749,000 14,249,000 13,758,000 13,496,000 12,786,000 11,929,000 11,279,000 10,932,000 10,381,000 10,439,000 8,127,000 7,508,000 4,546,000 5,042,000 4,324,000 3,955,000 2,943,000 2,459,000  2,189,000 1,456,000 1,076,000 826,000 729,000 556,000 184,000 174,000 174,000 3,730,000 3,730,000 3,730,000  3,730,000 3,824,000 3,824,000 3,832,000 3,801,000 3,795,000 4,014,000 4,123 4,123,000 4,122,000 4,071,000 4,042,000 4,256,000 4,252,000 4,042,000  4,179,000 3,931,000 3,842,000  3,214,150 3,112,331 2,622,405  2,108,200 1,815,343 
  leasehold and building improvements                              17,629,000                                                              
  assets under construction                              28,655,000 20,868,000 9,095,000 7,200,000 6,711,000 6,536,000 6,360,000 4,735,000 8,038,000 7,066,000 7,664,000 2,946,000 1,552,000 1,048,000 6,694,000 4,926,000 3,668,000                                              
  land                              4,466,000                                                              
  land improvements                              1,419,000                                                              
  buildings                              7,928,000 4,792,000 4,792,000 4,792,000 4,792,000 4,792,000 4,792,000 4,792,000 4,777,000 4,777,000                                                     
  furniture and fixtures                              4,531,000 3,156,000 2,897,000 2,581,000 2,515,000 2,515,000 2,037,000 1,825,000 1,265,000 1,038,000 933,000 933,000 939,000 268,000 268,000 268,000 28,000 28,000 28,000 28,000 28,000 23,000  23,000 23,000 23,000 20,000 20,000 20,000 16,000 10,000  299,000 299,000 299,000  299,000 299,000 299,000 299,000 299,000 299,000 299,000 299 299,000 299,000 299,000 299,000 299,000 299,000 299,000  299,000 299,000 281,000  206,226 206,226 211,530  202,193 194,113 
  less—accumulated depreciation                              -38,086,000 -35,036,000 -31,478,000 -28,153,000 -24,941,000 -21,980,000 -19,151,000 -16,386,000 -13,913,000 -11,851,000 -9,817,000 -8,027,000 -6,439,000                                                  
  net property and equipment                              79,986,000 55,706,000 42,048,000 38,395,000 38,142,000 38,473,000 36,233,000 35,046,000 34,096,000 32,075,000 27,312,000 21,567,000 19,947,000                                                  
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at december 31, 2017 and december 31, 2016                                                                                            
  leasehold improvements                               14,200,000 13,682,000 13,653,000 13,549,000 13,308,000 10,923,000 10,757,000 7,118,000 6,454,000 6,446,000 5,965,000 5,937,000 5,108,000 5,055,000 5,050,000 339,000 283,000 283,000 283,000 288,000 288,000  99,000 89,000 89,000 89,000 89,000 74,000 13,000 13,000  55,000 1,161,000 1,161,000  1,259,000 1,259,000 1,259,000 1,259,000 1,259,000 1,259,000 1,259,000 1,259 1,254,000 1,254,000 1,133,000 1,463,000 1,475,000 1,463,000 1,463,000  2,239,000 1,549,000 823,000  810,437 795,794 754,049  457,128 345,082 
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at september 30, 2017 and december 31, 2016                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at june 30, 2017 and december 31, 2016                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at march 31, 2017 and december 31, 2016                                                                                            
  debt and capital lease obligation, current portion                                  174,000 172,000 171,000 169,000 166,000 221,000 345,000                                                    
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at december 31, 2016 and december 31, 2015                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at september 30, 2016 and december 31, 2015                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at june 30, 2016 and december 31, 2015                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at march 31, 2016 and december 31, 2015                                                                                            
  long-term accrued interest                                         112,000 106,000 100,000 95,000 90,000 79,000 73,000 68,000 57,000 52,000 47,000  36,000                                       
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at december 31, 2015 and december 31, 2014                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at september 30, 2015 and december 31, 2014                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at june 30, 2015 and december 31, 2014                                                                                            
  capital lease obligation, current portion                                         269,000 360,000 449,000 361,000 356,000 347,000 342,000 337,000 355,000                                           
  lease incentive obligation, current portion                                         554,000 554,000 540,000 540,000 540,000 495,000                                              
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at march 31, 2015 and december 31, 2014                                                                                            
  deferred license fees, current portion                                              1,330,000 2,366,000 3,402,000 4,143,000 4,143,000 4,143,000  4,143,000 4,143,000 4,143,000 4,481,000 4,552,000 4,889,000   4,986,000 1,350,000 1,350,000 1,350,000  1,350,000 1,350,000 4,363,000 4,363,000 4,363,000 4,363,000 4,363,000 4,363 4,363,000 4,383,000 4,421,000                
  capital lease obligation, less current portion                                            177,000 269,000 449,000 538,000 625,000 796,000                                           
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at december 31, 2014 and december 31, 2013                                                                                            
  computer software and computer equipment                                           6,866,000                                                 
  accrued expenses                                           11,128,000 8,560,000 6,806,000 5,725,000 4,227,000 3,345,000 4,084,000 3,729,000 2,600,000  2,266,000 1,837,000 1,420,000 1,690,000 1,483,000 1,244,000 1,158,000 1,085,000 1,234,000 1,520,000 1,568,000 2,105,000  2,226,000 1,951,000 1,771,000 1,844,000 1,393,000 1,661,000 1,348,000 1,485 1,447,000 1,405,000 1,399,000 1,897,000 2,021,000 1,957,000 1,897,000  2,428,000 2,389,000 1,900,000  3,311,405 2,985,355 2,678,676  2,145,951 1,331,328 
  preferred stock, 0.01 par value authorized—5,000,000 shares, issued and outstanding—no shares at september 30, 2014 and december 31, 2013                                                                                            
  office and computer equipment                                            1,260,000 1,218,000 855,000 1,396,000 855,000 825,000 824,000 779,000  528,000 382,000 297,000 181,000 160,000 143,000 62,000 57,000 22,000 1,420,000 1,420,000 1,420,000  1,415,000 1,415,000 1,415,000 1,413,000 1,407,000 1,407,000 1,407,000 1,407 1,401,000 1,400,000 1,400,000 1,374,000 1,384,000 1,379,000 1,374,000  1,346,000 1,323,000 1,297,000  1,266,124 1,223,329 1,211,675  1,158,329 1,139,746 
  preferred stock, 0.01 par value authorized—5,000,000 shares, issued and outstanding—no shares at june 30, 2014 and december 31, 2013                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at march 31, 2014 and december 31, 2013                                                                                            
  deferred license fees, less current portion                                                 1,331,000 2,367,000 3,403,000  5,475,000 6,510,000 7,546,000 9,618,000 9,964,000 10,934,000   14,901,000 1,688,000 2,025,000 2,363,000  3,038,000 3,376,000 1,454,000 2,545,000 3,636,000 4,726,000 5,817,000 6,908 7,998,000 9,089,000 10,180,000                
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at september 30, 2013 and december 31, 2012                                                                                            
  other comprehensive income                                              118,000 17,000 71,000 92,000 53,000 21,000    3,000    5,000  71,000  1,000 24,000  14,000 12,000 5,000 6,000 9,000                      
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at june 30, 2013 and december 31, 2012                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at march 31, 2013 and december 31, 2012                                                                                            
  preferred stock, 0.01 par value                                                                                            
  authorized—5,000,000 shares                                                                                            
  issued and outstanding—no shares at september 30, 2012 and december 31, 2011                                                                                            
  authorized—100,000,000 shares                                                                                            
  issued and outstanding—63,753,363 and 56,624,763 shares at september 30, 2012 and december 31, 2011                                                 638,000                                           
  issued and outstanding—no shares at june 30, 2012 and december 31, 2011                                                                                            
  issued and outstanding—57,339,933 and 56,624,763 shares at june 30, 2012 and december 31, 2011                                                  573,000                                          
  issued and outstanding—no shares at march 31, 2012 and december 31, 2011                                                                                            
  issued and outstanding—57,109,496 and 56,624,763 shares at march 31, 2012 and december 31, 2011                                                   571,000                                         
  cash equivalents                                                    35,385,000                                        
  available-for-sale                                                                                            
  u.s. government agency securities                                                    27,994,000                                        
  certificates of deposit                                                    9,465,000                                        
  corporate bonds                                                    19,122,000                                        
  commercial paper                                                    999,000                                        
  total                                                    92,965,000                                        
  issued and outstanding—no shares at september 30, 2011 and december 31, 2010                                                                                            
  issued and outstanding—52,910,773 and 52,163,629 shares at september 30, 2011 and december 31, 2010                                                     529,000                                       
  long term debt                                                      1,000,000 1,000,000 1,000,000 1,000,000 1,000,000                                  
  long term accrued interest                                                      31,000 26,000 16,000 11,000 6,000                                  
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—no shares at june 30, 2011 and december 31, 2010                                                                                            
  less—accumulated depreciation and amortization                                                                     -5,959,000    -5,939                   
  issued and outstanding—no shares at march 31, 2011 and december 31, 2010                                                                                            
  issued and outstanding—52,191,956 and 52,163,629 shares at march 31, 2011 and december 31, 2010                                                       522,000                                     
  restricted cash                                                         500,000 500,000 500,000 600,000 600,000 600,000 700,000 700,000  700,000 800,000 800,000 800,000                       
  third party royalty obligation, current portion                                                        988,000 988,000 988,000   1,000,000                               
  third party royalty obligation, less current portion                                                           965,000 965,000 965,000                               
  issued and outstanding—no shares at september 30, 2010 and december 31, 2009                                                                                            
  issued and outstanding—40,480,084 and 35,523,140 shares at september 30, 2010 and december 31, 2009                                                        405,000                                    
  other comprehensive loss                                                                         -45                   
  issued and outstanding—no shares at june 30, 2010 and december 31, 2009                                                                                            
  issued and outstanding—40,201,552 and 35,523,140 shares at june 30, 2010 and december 31, 2009                                                         402,000                                   
  issued and outstanding—no shares at march 31, 2010 and december 31, 2009                                                                                            
  issued and outstanding—35,832,021 and 35,523,140 shares at march 31, 2010 and december 31, 2009                                                          358,000                                  
  patent costs, net of accumulated amortization of 2,820 at december 31, 2008                                                                                            
  liabilities and stockholders’ (deficit) equity                                                                                            
  third party royalty obligation                                                           1,000,000 1,000,000  3,000,000 2,000,000 1,500,000  250,000                          
  deferred revenue                                                           4,986,000 4,986,000                                
  stockholders’ (deficit) equity:                                                                                            
  preferred stock, 0.01 par value; 5,000,000 shares authorized; no shares issued and outstanding at june 30, 2009 and december 31, 2008                                                                                            
  treasury stock                                                                     -97,000    -97                   
  total stockholders’ (deficit) equity                                                           7,249,000 6,968,000                                
  liabilities and stockholders’ deficit                                                                                            
  stockholders’ deficit:                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—0 shares at march 31, 2009 and december 31, 2008, respectively                                                                                            
  total stockholders’ deficit                                                                                            
  revenue:                                                                                            
  product royalty fees                                                             7,000                               
  license fees                                                             993,000                               
  product                                                                                            
  cost of revenue:                                                                                            
  gross profit                                                             1,000,000                               
  operating expenses:                                                                                            
  research and development                                                             108,000                               
  general and administrative                                                             4,768,000                               
  restructuring                                                                                            
  income from operations                                                                                            
  interest income                                                             34,000                               
  net income                                                             -3,839,000                               
  net income per share                                                             -130                               
  weighted-average common shares outstanding—basic and diluted                                                             30,230,000                               
  patent costs, net of accumulated amortization of 2,843 and 3,019 at september 30, 2008 and december 31, 2007, respectively                                                              213,000                              
  stockholders’ equity                                                                                            
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—0 shares at september 30, 2008 and and december 31, 2007                                                                                            
  patent costs, net of accumulated amortization of 2,837 and 3,019 at june 30, 2008 and december 31, 2007, respectively                                                               200,000                             
  preferred stock, 0.01 par value authorized—5,000,000 shares issued and outstanding—0 shares at june 30, 2008 and and december 31, 2007                                                                                            
  patent costs, net of accumulated amortization of 3,053 and 3,019 at march 31, 2008 and december 31, 2007, respectively                                                                452,000                            
  issued and outstanding—0 shares at march 31, 2008 and and december 31, 2007                                                                                            
  issued and outstanding—27,233,957 and 27,225,541 shares at march 31, 2008 and december 31, 2007, respectively                                                                273,000                            
  patent costs, net of accumulated amortization of 2,983 and 2,871 at september 30, 2007 and december 31, 2006, respectively                                                                  450,000                          
  issued and outstanding—0 shares at september 30, 2007 and december 31, 2006                                                                                            
  issued and outstanding— 27,134,193 and 26,863,363 shares at september 30, 2007 and december 31, 2006, respectively                                                                  271,000                          
  patent costs, net of accumulated amortization of 2,947 and 2,871 at june 30, 2007 and december 31, 2006, respectively                                                                   557,000                         
  issued and outstanding—0 shares at june 30, 2007 and december 31, 2006                                                                                            
  issued and outstanding— 27,063,123 and 26,863,363 shares at june 30, 2007 and december 31, 2006, respectively                                                                   270,000                         
  patent costs, net of accumulated amortization of 2,911 and 2,871 at march 31, 2007 and december 31, 2006, respectively                                                                    609,000                        
  issued and outstanding—26,929,093 and 26,863,363 shares at march 31, 2007 and december 31, 2006, respectively                                                                    269,000                        
  patent costs, net of accumulated amortization of 2,279 and 2,871 at december 31, 2005 and 2006, respectively                                                                     763,000                       
  issued and outstanding—26,436,498 and 26,863,363 shares at december 31, 2005 and 2006, respectively                                                                     269,000                       
  patent costs and other assets, net of accumulated amortization of 2,279 and 2,740 at december 31, 2005 and september 30, 2006, respectively                                                                      839,000                      
  issued and outstanding—26,436,498 and 26,690,863 shares at december 31, 2005 and september 30, 2006, respectively                                                                      267,000                      
  patent costs and other assets, net of accumulated amortization of 2,279 and 2,577 at december 31, 2005 and june 30, 2006, respectively                                                                       1,115,000                     
  issued and outstanding—26,436,498 and 26,533,153 shares at                                                                                            
  december 31, 2005 and june 30, 2006, respectively                                                                       265,000                     
  patent costs and cther assets, net of accumulated amortization of 2,279 and 2,410 at december 31, 2005 and march 31, 2006, respectively                                                                        1,322,000                    
  issued and outstanding—26,436,498 and 26,472,091 shares at december 31, 2005 and march 31, 2006, respectively                                                                        265,000                    
  patent costs and other assets, net of accumulated amortization of 1,718 and 2,279 at december 31, 2004 and 2005, respectively                                                                         1,419                   
  issued and outstanding—26,285,067 and 26,436,498 shares at                                                                                            
  december 31, 2004 and 2005, respectively                                                                         264                   
  notes receivable                                                                                            
  deferred compensation                                                                                            
  patent costs and cther assets, net of accumulated amortization of approximately 1,718 and 2,085 at december 31, 2004 and september 30, 2005, respectively                                                                          1,614,000                  
  issued and outstanding—26,285,067 and 26,398,466 shares at december 31, 2004 and september 30, 2005, respectively                                                                          264,000                  
  patent costs and other assets, net of accumulated amortization of approximately 1,718 and 1,948 at december 31, 2004 and june 30, 2005, respectively                                                                           1,830,000                 
  issued and outstanding—26,285,067 and 26,350,613 shares at december 31, 2004 and june 30, 2005, respectively                                                                           264,000                 
  patent costs and other assets, net of accumulated amortization of approximately 1,718 and 1,833 at december 31, 2004 and march 31, 2005, respectively                                                                            1,922,000                
  prepaid expenses                                                                             1,864,000 1,761,000 2,023,000 1,864,000  1,437,000 1,454,000 1,805,000  761,150 1,183,146 1,270,333  1,207,813 425,927 
  patent costs and other assets                                                                             2,577,000 2,361,000 2,445,000 2,577,000  2,641,000 2,738,000 2,870,000        
  deferred licensing fees, current portion                                                                             4,514,000 4,514,000 4,514,000 4,514,000  4,621,000 1,621,000 1,621,000  1,620,680 1,620,693     
  deferred licensing fees, less current portion                                                                             14,601,000 12,344,000 13,472,000 14,601,000  16,778,000 5,683,000 6,088,000  6,898,213 7,303,370     
  less–accumulated depreciation and amortization                                                                                            
  unrealized gain on marketable securities                                                                                  14,000 49,000 75,000        
  short-term investments                                                                                      26,617,855      
  interest receivable                                                                                      534,245      
  patent costs, net and other assets                                                                                      2,888,731 2,831,098 2,865,450  1,300,133 1,252,032 
  subscriptions receivable                                                                                            
  unrealized losses on investments                                                                                            
  deficit accumulated during the development stage                                                                                            
  deferred licensing fees                                                                                        511,844    
  series a convertible preferred stock, 0.01 par value                                                                                            
  series b convertible preferred stock, 0.01 par value                                                                                            
  series c convertible preferred stock, 0.01 par value                                                                                            
  series d convertible preferred stock, 0.01 par value                                                                                            
  1,852,499                                                                                           3,494,284 
  863,532                                                                                           2,165,044 

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