7Baggers

DexCom, Inc
(NASDAQ:DXCM) 

DXCM stock logo

DexCom, Inc., a medical device company, focuses on the design, development, and commercialization of continuous glucose monitoring (CGM) systems in the United States and internationally. The company offers its systems for use by people with diabetes, as well as for use by healthcare providers. Its p...

Founded: 1999
Full Time Employees: 3,900
CEO: Kevin R. Sayer  
Sector: Healthcare
Industry: Diagnostics & Research

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Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2006-12-31 2005-12-31 
                                                                                 
      revenue
    1,191,900,000 1,259,600,000 1,209,300,000 1,157,100,000 1,036,000,000 1,113,500,000 994,200,000 1,004,300,000 921,000,000 1,034,500,000 975,000,000 871,300,000 741,500,000 815,200,000 769,600,000 696,200,000 628,800,000 698,200,000 650,200,000 595,100,000 505,000,000 568,900,000 500,900,000 451,800,000 405,100,000 462,800,000 396,300,000 336,400,000 280,500,000 338,000,000 266,700,000 242,500,000 184,400,000 124,375,000 184,600,000 170,600,000 142,300,000    116,200,000                                 1,528,000 1,224,000   
      yoy
    15.05% 13.12% 21.64% 15.21% 12.49% 7.64% 1.97% 15.26% 24.21% 26.90% 26.69% 25.15% 17.92% 16.76% 18.36% 16.99% 24.51% 22.73% 29.81% 31.72% 24.66% 22.93% 26.39% 34.30% 44.42% 36.92% 48.59% 38.72% 52.11% 171.76% 44.47% 42.15% 29.59%    22.46%                                         
      qoq
    -5.37% 4.16% 4.51% 11.69% -6.96% 12.00% -1.01% 9.04% -10.97% 6.10% 11.90% 17.51% -9.04% 5.93% 10.54% 10.72% -9.94% 7.38% 9.26% 17.84% -11.23% 13.58% 10.87% 11.53% -12.47% 16.78% 17.81% 19.93% -17.01% 26.73% 9.98% 31.51% 48.26% -32.62% 8.21% 19.89%                                      24.84%    
      cost of sales
    441,600,000 466,900,000 477,900,000 468,300,000 447,000,000 457,700,000 400,400,000 377,600,000 359,100,000 377,900,000 351,700,000 324,900,000 278,900,000 273,900,000 275,400,000 246,700,000 230,700,000 225,600,000 203,300,000 178,000,000 161,100,000 169,800,000 160,500,000 167,700,000 148,600,000 153,500,000 149,400,000 129,900,000 111,700,000 115,200,000 98,100,000 88,900,000 65,500,000 67,500,000 57,600,000 53,100,000 48,200,000 35,100,000 47,500,000 51,800,000 41,100,000                                 3,655,000 3,113,000   
      gross profit
    750,300,000 792,700,000 731,400,000 688,800,000 589,000,000 655,800,000 593,800,000 626,700,000 561,900,000 656,600,000 623,300,000 546,400,000 462,600,000 541,300,000 494,200,000 449,500,000 398,100,000 472,600,000 446,900,000 417,100,000 343,900,000 399,100,000 340,400,000 284,100,000 256,500,000 309,300,000 246,900,000 206,500,000 168,800,000 222,800,000 168,600,000 153,600,000 118,900,000 153,500,000 127,000,000 117,500,000 94,100,000 116,700,000 101,100,000 85,500,000 75,100,000 91,200,000 74,700,000 66,000,000 46,500,000 59,400,000 47,200,000 39,900,000 29,800,000 34,100,000 27,600,000 21,900,000 16,500,000 17,568,000 8,402,000 11,243,000 9,387,000 10,693,000 8,164,000                   
      yoy
    27.39% 20.88% 23.17% 9.91% 4.82% -0.12% -4.73% 14.70% 21.47% 21.30% 26.12% 21.56% 16.20% 14.54% 10.58% 7.77% 15.76% 18.42% 31.29% 46.81% 34.07% 29.03% 37.87% 37.58% 51.95% 38.82% 46.44% 34.44% 41.97% 45.15% 32.76% 30.72% 26.35% 31.53% 25.62% 37.43% 25.30% 27.96% 35.34% 29.55% 61.51% 53.54% 58.26% 65.41% 56.04% 74.19% 71.01% 82.19% 80.61% 94.10% 228.49% 94.79% 75.78% 64.29% 2.92%                       
      qoq
    -5.35% 8.38% 6.18% 16.94% -10.19% 10.44% -5.25% 11.53% -14.42% 5.34% 14.07% 18.12% -14.54% 9.53% 9.94% 12.91% -15.76% 5.75% 7.14% 21.29% -13.83% 17.24% 19.82% 10.76% -17.07% 25.27% 19.56% 22.33% -24.24% 32.15% 9.77% 29.18% -22.54% 20.87% 8.09% 24.87% -19.37% 15.43% 18.25% 13.85% -17.65% 22.09% 13.18% 41.94% -21.72% 25.85% 18.30% 33.89% -12.61% 23.55% 26.03% 32.73% -6.08% 109.09% -25.27% 19.77% -12.21% 30.98%                    
      gross margin %
    62.95% 62.93% 60.48% 59.53% 56.85% 58.90% 59.73% 62.40% 61.01% 63.47% 63.93% 62.71% 62.39% 66.40% 64.22% 64.56% 63.31% 67.69% 68.73% 70.09% 68.10% 70.15% 67.96% 62.88% 63.32% 66.83% 62.30% 61.39% 60.18% 65.92% 63.22% 63.34% 64.48% 123.42% 68.80% 68.87% 66.13% Infinity% Infinity% Infinity% 64.63% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% Infinity% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% 0% 0%   
      operating expenses:
                                                                                 
      research and development
    145,300,000 148,200,000 157,500,000 148,200,000 145,200,000 139,500,000 135,400,000 136,000,000 141,500,000 136,100,000 131,400,000 119,300,000 119,000,000 116,300,000 110,300,000 121,700,000 135,900,000 149,800,000 128,800,000 129,100,000 109,400,000 119,200,000 87,700,000 79,900,000 73,100,000 78,800,000 66,700,000 69,000,000 59,000,000 57,600,000 50,100,000 47,200,000 44,800,000 48,700,000 43,300,000 45,300,000 48,100,000 43,700,000 43,900,000 36,300,000 32,200,000 28,500,000 64,800,000 24,400,000 19,800,000 21,600,000 18,500,000 14,800,000 14,500,000 12,600,000 11,800,000 11,100,000 9,300,000 8,705,000 10,582,000 10,498,000 9,715,000 9,232,000 8,231,000 7,016,000 6,268,000 6,902,000 6,161,000 5,425,000 4,739,000 4,172,000 3,496,000 3,455,000 3,171,000 4,571,000 5,418,000 4,797,000 4,843,000 4,397,000 3,671,000   
      selling, general and administrative
    349,700,000 321,500,000 331,400,000 328,000,000 310,100,000 327,400,000 306,400,000 332,700,000 319,300,000 308,800,000 284,700,000 297,300,000 294,600,000 297,800,000 234,600,000 248,900,000 220,900,000 235,100,000 199,800,000 187,000,000 188,600,000 175,900,000 158,600,000 136,400,000 149,800,000 129,000,000 124,200,000 138,300,000 124,200,000 112,100,000 104,600,000 111,300,000 104,800,000 92,800,000 84,200,000 85,800,000 86,400,000 79,100,000 75,700,000 69,300,000 62,100,000 61,100,000 52,300,000 45,200,000 39,400,000 36,200,000 33,700,000 30,900,000 27,600,000 23,800,000 21,600,000 20,700,000 18,100,000 17,195,000 15,142,000 15,394,000 15,069,000 13,737,000 13,241,000 12,244,000 10,718,000 9,973,000 10,377,000 10,362,000 9,794,000 9,397,000 8,948,000 8,952,000 7,903,000 7,349,000 6,652,000 7,247,000 6,421,000 5,653,000 5,943,000   
      total operating expenses
    495,000,000 469,700,000 488,900,000 476,200,000 455,300,000 466,900,000 441,800,000 468,700,000 460,800,000 439,700,000 417,800,000 418,300,000 415,400,000 415,900,000 346,700,000 372,500,000 356,800,000 472,000,000 328,600,000 316,100,000 298,000,000 295,100,000 246,300,000 216,300,000 222,900,000 207,800,000 190,900,000 207,300,000 183,200,000 387,400,000 154,700,000 158,500,000 149,600,000 141,500,000 127,500,000 131,100,000 134,500,000 122,800,000 119,600,000 105,600,000 94,300,000 89,600,000 117,100,000 69,600,000 59,200,000 57,800,000 52,200,000 45,700,000 42,100,000 36,400,000 33,400,000 31,800,000 27,400,000 25,900,000 25,724,000 25,892,000 24,784,000 22,969,000 21,472,000 19,260,000 16,986,000 16,875,000 16,538,000 15,787,000 14,533,000 13,569,000 12,444,000 12,407,000 11,074,000 11,920,000 12,070,000 12,044,000 11,264,000 10,050,000 9,614,000   
      operating income
    255,300,000 323,000,000 242,500,000 212,600,000 133,700,000 188,900,000 152,000,000 158,000,000 101,100,000 216,900,000 205,500,000 128,100,000 47,200,000 125,400,000 147,500,000 77,000,000 41,300,000 600,000 118,300,000 101,000,000 45,900,000 104,000,000 94,100,000 67,800,000 33,600,000 101,500,000 56,000,000 -800,000 -14,400,000 -164,600,000 13,900,000 -4,900,000 -30,700,000 12,000,000 -500,000 -13,600,000 -40,400,000 -6,100,000 -18,500,000 -20,100,000 -19,200,000 1,600,000 -42,400,000 -3,600,000 -12,700,000 1,600,000 -5,000,000 -5,800,000 -12,300,000 -2,300,000 -5,800,000 -9,900,000 -10,900,000 -8,332,000 -17,322,000 -14,649,000 -15,397,000 -12,276,000 -13,308,000 -7,389,000 -11,870,000 -9,886,000 -13,062,000 -11,268,000 -11,074,000 -9,462,000 -11,579,000 -13,455,000 -11,337,000 -12,738,000 -13,990,000 -13,455,000 -12,644,000     
      yoy
    90.95% 70.99% 59.54% 34.56% 32.25% -12.91% -26.03% 23.34% 114.19% 72.97% 39.32% 66.36% 14.29% 20800.00% 24.68% -23.76% -10.02% -99.42% 25.72% 48.97% 36.61% 2.46% 68.04% -8575.00% -333.33% -161.66% 302.88% -83.67% -53.09% -1471.67% -2880.00% -63.97% -24.01% -296.72% -97.30% -32.34% 110.42% -481.25% -56.37% 458.33% 51.18% 0.00% 748.00% -37.93% 3.25% -169.57% -13.79% -41.41% 12.84% -72.40% -66.52% -32.42% -29.21% -32.13% 30.16% 98.25% 29.71% 24.18% 1.88% -34.42% 7.19% 4.48% 12.81% -16.25% -2.32% -25.72% -17.23% 0.00% -10.34%         
      qoq
    -20.96% 33.20% 14.06% 59.01% -29.22% 24.28% -3.80% 56.28% -53.39% 5.55% 60.42% 171.40% -62.36% -14.98% 91.56% 86.44% 6783.33% -99.49% 17.13% 120.04% -55.87% 10.52% 38.79% 101.79% -66.90% 81.25% -7100.00% -94.44% -91.25% -1284.17% -383.67% -84.04% -355.83% -2500.00% -96.32% -66.34% 562.30% -67.03% -7.96% 4.69% -1300.00% -103.77% 1077.78% -71.65% -893.75% -132.00% -13.79% -52.85% 434.78% -60.34% -41.41% -9.17% 30.82% -51.90% 18.25% -4.86% 25.42% -7.75% 80.11% -37.75% 20.07% -24.31% 15.92% 1.75% 17.04% -18.28% -13.94% 18.68% -11.00% -8.95% 3.98% 6.41%      
      operating margin %
    21.42% 25.64% 20.05% 18.37% 12.91% 16.96% 15.29% 15.73% 10.98% 20.97% 21.08% 14.70% 6.37% 15.38% 19.17% 11.06% 6.57% 0.09% 18.19% 16.97% 9.09% 18.28% 18.79% 15.01% 8.29% 21.93% 14.13% -0.24% -5.13% -48.70% 5.21% -2.02% -16.65% 9.65% -0.27% -7.97% -28.39% -Infinity% -Infinity% -Infinity% -16.52% Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 0% 0%   
      other income
    14,200,000 17,700,000 109,800,000 28,500,000 20,600,000 22,400,000 25,400,000 29,800,000 31,400,000 30,300,000 33,900,000                   -1,150,000 -1,600,000 -5,600,000 2,600,000 -100,000 1,300,000 1,800,000 400,000                                         
      income before income taxes
    269,500,000 340,700,000 352,300,000 241,100,000 154,300,000 211,300,000 177,400,000 187,800,000 132,500,000 246,200,000 240,400,000 159,300,000 64,500,000 133,200,000 146,200,000 75,300,000 36,100,000 -14,700,000 90,700,000 76,700,000 21,200,000 81,300,000 75,100,000 46,200,000 22,400,000 94,300,000 45,800,000 -9,300,000 -26,600,000 -176,900,000 44,800,000 29,600,000 -24,000,000 8,600,000 -2,500,000 -14,400,000 -40,300,000 -7,000,000 -18,600,000 -20,100,000          -2,600,000 -6,000,000 -10,100,000 -11,100,000 -8,495,000 -17,306,000 -14,627,000 -15,372,000                     
      income tax expense
    70,000,000 73,400,000 68,500,000 61,300,000 48,900,000 59,600,000 42,800,000 44,300,000 -13,900,000 -10,100,000 119,700,000 43,400,000 15,900,000 2,050,000 45,000,000   3,625,000 19,800,000 13,800,000 -19,100,000 -273,900,000 2,900,000 -100,000 2,500,000 1,600,000   300,000    200,000    1,400,000 400,000 200,000 100,000              -13,000 -43,000 64,000 -1,308,000                     
      net income
    199,500,000 267,300,000 283,800,000 179,800,000 105,400,000 151,700,000 134,600,000 143,500,000 146,400,000 256,300,000 120,700,000 115,900,000 48,600,000 91,800,000 101,200,000 50,900,000 97,300,000 -19,400,000 70,900,000 62,900,000 40,300,000 355,200,000 72,200,000 46,300,000 19,900,000 92,700,000 45,800,000 -10,500,000 -26,900,000 -179,700,000 46,600,000 30,200,000 -24,200,000 -9,400,000 -2,000,000 2,900,000 -41,700,000 -7,400,000 -18,800,000 -20,200,000 -19,200,000 1,500,000 -42,500,000 -3,700,000 -12,900,000 1,300,000 -5,200,000 -6,000,000 -12,500,000 -2,600,000 -6,000,000 -10,100,000 -11,100,000 -8,482,000 -17,263,000 -14,691,000 -14,064,000 -12,251,000 -13,278,000 -7,367,000 -11,850,000 -9,812,000 -13,398,000 -11,687,000 -20,273,000 -11,529,000 -13,523,000 -15,330,000 -13,142,000 -13,450,000 -14,688,000 -14,074,000 -12,972,000 -12,229,000 -11,384,000   
      yoy
    89.28% 76.20% 110.85% 25.30% -28.01% -40.81% 11.52% 23.81% 201.23% 179.19% 19.27% 127.70% -50.05% -573.20% 42.74% -19.08% 141.44% -105.46% -1.80% 35.85% 102.51% 283.17% 57.64% -540.95% -173.98% -151.59% -1.72% -134.77% 11.16% 1811.70% -2430.00% 941.38% -41.97% 27.03% -89.36% -114.36% 117.19% -593.33% -55.76% 445.95% 48.84% 15.38% 717.31% -38.33% 3.20% -150.00% -13.33% -40.59% 12.61% -69.35% -65.24% -31.25% -21.08% -30.76% 30.01% 99.42% 18.68% 24.86% -0.90% -36.96% -41.55% -14.89% -0.92% -23.76% 54.26% -14.28% -7.93% 8.92% 1.31% 9.98% 29.02%       
      qoq
    -25.36% -5.81% 57.84% 70.59% -30.52% 12.70% -6.20% -1.98% -42.88% 112.34% 4.14% 138.48% -47.06% -9.29% 98.82% -47.69% -601.55% -127.36% 12.72% 56.08% -88.65% 391.97% 55.94% 132.66% -78.53% 102.40% -536.19% -60.97% -85.03% -485.62% 54.30% -224.79% 157.45% 370.00% -168.97% -106.95% 463.51% -60.64% -6.93% 5.21% -1380.00% -103.53% 1048.65% -71.32% -1092.31% -125.00% -13.33% -52.00% 380.77% -56.67% -40.59% -9.01% 30.87% -50.87% 17.51% 4.46% 14.80% -7.73% 80.24% -37.83% 20.77% -26.77% 14.64% -42.35% 75.84% -14.75% -11.79% 16.65% -2.29% -8.43% 4.36% 8.50% 6.08% 7.42%    
      net income margin %
    16.74% 21.22% 23.47% 15.54% 10.17% 13.62% 13.54% 14.29% 15.90% 24.78% 12.38% 13.30% 6.55% 11.26% 13.15% 7.31% 15.47% -2.78% 10.90% 10.57% 7.98% 62.44% 14.41% 10.25% 4.91% 20.03% 11.56% -3.12% -9.59% -53.17% 17.47% 12.45% -13.12% -7.56% -1.08% 1.70% -29.30% -Infinity% -Infinity% -Infinity% -16.52% Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -800.33% -930.07%   
      basic net income per share
    0.52 0.69 0.73 0.46 0.27 0.38 0.34 0.36 0.38 0.66 0.31 0.3 0.13 0.24 0.26 0.13 -0.2 0.73 0.65 0.42 3.75 0.75 0.49 0.22 1.02 0.5 -0.12  0.15 0.53 0.34          -0.188 -0.53 -0.05    -0.08                              
      shares used to compute basic net income per share
    385.1 -1.2 391.1 392.1 391.1 -1 394.2 399.2 390.2 -0.7 386.6 386.7 386.7 -1 389.8 392.5 97.2 0.1 96.9 96.7 96.3 0.6 95.8 93.8 91.8 0.2 91.3 91.1  22 88.5 88.2    86.4      19.8 80.5 79.6    75                              
      diluted net income per share
    0.51 0.67 0.7 0.45 0.27 0.38 0.34 0.35 0.36 0.61 0.29 0.28 0.12 0.22 0.24 0.12 0.93 -0.19 0.71 0.63 0.41 3.63 0.73 0.48 0.21 1.01 0.5 -0.12  0.148 0.52 0.34          -0.188 -0.53 -0.05    -0.09                              
      shares used to compute diluted net income per share
    393.6 -2.2 407.4 408.2 407.5 -2 410.2 416.8 416.7 -2.8 426.8 431.5 418.5 -0.5 425.8 421.4 107.2 0.3 100.5 99.6 99.4 0.6 99.5 97 94.1 0.1 92.5 91.1  22.325 90.3 89.4          19.8 80.5 79.6    75.3                              
      amortization of intangible assets
             1,300,000 1,700,000 1,700,000 1,800,000 1,800,000 1,800,000 1,900,000                                                              
      income from equity investments
             250,000 1,000,000      200,000            -4,200,000 -4,900,000 34,900,000 42,700,000 7,400,000                                             
      interest expense
               -5,900,000 -4,600,000 -4,700,000 -4,600,000 -4,700,000 -4,600,000 -25,200,000 -25,100,000 -25,200,000 -24,800,000 -24,600,000 -24,400,000 -20,300,000 -15,400,000 -15,300,000 -15,100,000 -15,000,000 -14,900,000 -8,200,000 -4,900,000 -4,800,000 -4,800,000 -4,700,000 -4,500,000 -3,100,000 -500,000 -300,000 -200,000 -100,000 -100,000  -100,000 -100,000 -200,000 -200,000 -200,000 -200,000 -200,000 -300,000 -200,000 -200,000 -200,000 -198,000 -1,000 -1,000  -1,000 -1,000 -3,000 -6,000 -8,000 -44,000 -197,000 -1,299,000 -2,098,000 -2,037,000 -1,982,000 -1,928,000 -879,000 -913,000 -926,000 -893,000     
      interest and other income
               37,100,000 21,900,000 12,500,000 3,300,000 3,000,000 -800,000 -1,000,000 -1,700,000 900,000 100,000 1,900,000 5,900,000 4,100,000 4,200,000 8,100,000 4,900,000 6,500,000 6,900,000                         35,000 17,000 23,000 25,000         80,750 93,000           
      * we adjusted our 2021 amounts to reflect the simplified convertible instruments accounting guidance, which we adopted on a full retrospective basis. all periods presented have also been adjusted to reflect the four-for-one stock split. refer to note 1, “organization and significant accounting policies,” for further information.
                                                                                 
      income tax benefit
                   24,400,000 -61,200,000           1,200,000  -550,000 -1,800,000 -600,000  -4,100,000 -500,000 -17,300,000                                          
      * we adjusted our 2021 amounts to reflect the simplified convertible instruments accounting guidance, which we adopted on a full retrospective basis. refer to note 1 “organization and significant accounting policies” for further information.
                                                                                 
      loss on extinguishment of debt
                     -700,000 -800,000    -500,000 -5,400,000                                                      
      loss from equity investments
                                                                                 
      basic and diluted net income per share
                                -0.3    -0.28 -0.11 -0.02 0.03 -0.49 -0.08 -0.22 -0.24     -0.17    -0.17   -0.14 -0.16     -0.125 -0.2 -0.11 -0.19 -0.203 -0.23 -0.2 -0.4 -0.24 -0.29 -0.33 -0.33 -0.355 -0.5 -0.48 -0.44 -0.298 -0.4   
      shares used to compute basic and diluted net income per share
                                90.3    87.3 0.2 86.7  85.2 0.3 84.1 83.6     77.8    73.3   70.9 69.8     16,227.5 67,397 65,096 62,179 13,926.75 58,200 57,554 51,291 10,949.25 45,919 45,832 39,569 7,353.75 29,627 29,387 29,228 7,070,663.25 28,324,661   
      operating expenses
                                                                                 
      interest income
                                 1,550,000 2,500,000 2,200,000 1,500,000 1,400,000 1,200,000 500,000 200,000 100,000 100,000 100,000 100,000                 25,000 31,000 25,000 26,000 22,000 20,000 23,000 30,000   107,000 123,000 133,000 215,000 307,000 565,000 -52,000 119,000   
      shares used to compute dilutive net income per share
                                       87.4                                          
      product revenue
                                         171,200,000 148,600,000 137,300,000  130,800,000 104,200,000 92,900,000 72,800,000 84,300,000 67,900,000 58,200,000 46,700,000 51,300,000 42,500,000 35,500,000 27,800,000 31,777,000 21,081,000 21,524,000 18,618,000 20,936,000 16,656,000 15,179,000 13,139,000 13,592,000 10,776,000 9,043,000 6,764,000 6,632,000 4,620,000 4,112,000 2,672,000 2,465,000 1,878,000 1,940,000      
      development grant and other revenue
                                              1,000,000 300,000   1,100,000 600,000 400,000 400,000 400,000 300,000 1,800,000 1,489,000 2,008,000 1,926,000 1,477,000 1,485,000 1,598,000 6,238,000 1,035,000 2,044,000 888,000 2,743,000 2,781,000             
      total revenue
                                         171,200,000 148,600,000 137,300,000  130,800,000 105,200,000 93,200,000 72,800,000 84,300,000 69,000,000 58,800,000 47,100,000 51,700,000 42,900,000 35,800,000 29,600,000 33,266,000 23,089,000 23,450,000 20,095,000 22,421,000 18,254,000 21,417,000 14,174,000 15,636,000 11,664,000 11,786,000 9,545,000 10,471,000 7,259,000 6,751,000 5,212,000 4,073,000 1,920,000 1,982,000      
      basic and diluted net loss per share
                                            -0.23         -0.095 -0.08   -0.168 -0.25 -0.21 -0.21                     
      shares used to compute basic and diluted net loss per share
                                            82.1         17.675 71.4   17,123.5 69,052 68,635 67,790                     
      product cost of sales
                                             39,600,000 30,500,000 27,200,000 26,300,000 24,900,000 21,800,000 18,700,000 16,900,000 17,200,000 14,800,000 13,700,000 12,400,000 14,433,000 13,391,000 10,889,000 9,587,000 10,695,000 9,230,000 8,351,000 8,352,000 7,664,000 6,982,000 6,318,000 5,140,000 5,478,000 4,589,000 4,627,000 3,522,000 3,550,000 3,577,000 3,144,000 3,112,000     
      development and other cost of sales
                                                   200,000 400,000 400,000 500,000 200,000 700,000 1,265,000 1,296,000 1,318,000 1,121,000 1,033,000 860,000 1,195,000 706,000 983,000 1,206,000 949,000 946,000             
      total cost of sales
                                             39,600,000 30,500,000 27,200,000 26,300,000 24,900,000 21,800,000 18,900,000 17,300,000 17,600,000 15,300,000 13,900,000 13,100,000 15,698,000 14,687,000 12,207,000 10,708,000 11,728,000 10,090,000 9,546,000 9,058,000 8,647,000 8,188,000 7,267,000 6,086,000 6,364,000 6,394,000 7,799,000 5,475,000 4,891,000 3,840,000 3,393,000 3,242,000     
      basic net loss per share
                                                 -0.08 -0.07                               
      shares used to compute basic net loss per share
                                                 18.675 75.8                               
      diluted net loss per share
                                                 -0.083 -0.08                               
      shares used to compute diluted net loss per share
                                                 18.75 76.1                               
      loss on debt extinguishment upon conversion of convertible debt
                                                                 -3,000 -312,000 -245,000 -7,930,000             
      gross margin
                                                               11,871,000 5,116,000 6,989,000 3,476,000 4,519,000 3,459,000 4,107,000 865,000  -263,000 -818,000 -1,920,000 -1,411,000 -1,380,000     
      development grant revenue
                                                                     1,954,500 2,639,000 2,639,000 2,540,000 1,608,000 42,000 42,000 38,000     
      development cost of sales
                                                                     1,732,500 1,805,000 3,172,000 1,953,000 1,341,000 263,000 249,000 130,000     
      gross deficit
                                                                       -1,048,000          
      product revenues
                                                                            1,824,000     
      total revenues
                                                                            1,862,000     
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2006-12-31 2005-12-31 
                                                                                   
        assets
                                                                                   
        current assets:
                                                                                   
        cash and cash equivalents
      1,118,200,000 917,700,000 1,835,700,000 1,159,000,000 904,900,000 606,100,000 621,200,000 939,200,000 851,200,000 566,300,000 643,700,000 1,194,900,000 623,200,000 642,300,000 698,100,000 735,400,000 716,000,000 1,052,600,000 1,444,300,000 1,158,800,000 733,800,000 817,600,000 673,500,000 530,000,000 584,600,000 446,200,000 395,600,000 709,200,000 1,285,100,000 1,137,000,000 367,400,000 300,200,000 420,400,000 441,500,000 402,100,000 395,900,000 153,500,000 94,500,000 97,700,000 87,500,000 77,900,000 86,100,000 85,300,000 67,700,000 54,200,000 71,800,000 63,200,000 49,500,000 45,700,000 43,200,000 33,400,000 28,200,000 18,900,000 8,100,000 4,744,000 5,985,000 5,119,000 2,553,000 17,523,000 33,889,000 3,805,000 4,889,000 5,529,000 6,090,000 10,700,000 3,577,000 6,362,000 4,208,000 9,276,000 12,700,000 4,642,000 4,963,000 23,952,000 23,115,000 15,176,000 18,167,066 37,247,064 
        short-term marketable securities
      1,297,000,000 1,081,000,000 1,486,400,000 1,770,300,000 1,796,500,000 1,973,300,000 1,871,100,000 2,181,500,000 2,045,800,000 2,157,800,000 2,596,600,000 2,441,300,000 1,943,800,000 1,813,900,000 1,673,800,000 2,019,400,000 1,972,200,000 1,678,600,000 1,253,600,000 1,426,100,000 1,898,800,000 1,890,100,000 1,930,300,000 1,978,800,000 925,900,000 1,087,100,000 1,034,300,000 668,300,000 72,900,000 248,600,000 301,300,000 305,900,000 113,500,000                                             
        accounts receivable
      1,088,600,000 1,216,100,000 1,109,600,000 1,348,800,000 1,155,200,000 1,005,700,000 1,002,000,000 945,200,000 978,600,000 973,900,000 785,700,000 750,600,000 636,800,000 713,300,000 564,100,000 560,800,000 544,500,000 514,300,000 529,100,000 483,500,000 443,400,000 428,500,000 370,000,000 296,500,000 300,700,000 286,300,000 234,900,000 217,300,000 204,700,000 226,700,000 169,800,000 162,000,000 123,900,000 134,300,000 110,500,000 101,700,000 85,900,000 101,700,000 76,800,000 73,800,000 67,300,000 74,100,000 55,800,000 45,500,000 40,200,000 42,400,000 31,400,000 28,600,000 23,800,000 26,100,000 21,600,000 17,700,000 16,300,000 19,500,000 12,357,000 12,900,000 12,543,000 12,547,000 9,003,000 8,694,000 7,158,000 6,671,000 5,102,000 4,661,000 3,801,000 3,490,000 2,487,000 2,067,000 1,345,000 1,118,000 429,000 568,000 321,000 215,000 171,000 120,477  
        inventory
      693,600,000 629,100,000 604,100,000 570,700,000 538,200,000 542,600,000 586,300,000 570,300,000 589,100,000 559,600,000 498,600,000 421,100,000 366,000,000 306,700,000 311,000,000 339,500,000 342,200,000 357,300,000 351,300,000 319,300,000 289,700,000 234,700,000 200,700,000 165,300,000 141,900,000 119,800,000 120,400,000 117,900,000 101,100,000 70,700,000 55,200,000 46,200,000 51,600,000 45,200,000 43,300,000 42,800,000 46,500,000 45,400,000 44,700,000 42,900,000 46,100,000 35,200,000 30,600,000 22,400,000 18,400,000 16,000,000 14,300,000 11,600,000 8,900,000 9,000,000 10,000,000 7,300,000 7,500,000 7,400,000 7,141,000 7,378,000 8,044,000 8,171,000 6,455,000 6,258,000 6,425,000 8,112,000 6,353,000 4,087,000 3,851,000 2,641,000 1,932,000 1,363,000 2,365,000 2,446,000 2,590,000 2,771,000 1,824,000 1,139,000 1,035,000 1,413,024  
        prepaid and other current assets
      134,300,000 189,400,000 183,700,000 181,400,000 159,000,000 173,700,000 182,200,000 212,200,000 156,000,000 168,300,000 173,800,000 195,000,000 197,600,000 192,600,000 151,500,000 153,600,000 171,700,000 81,600,000 77,900,000 86,500,000 79,400,000 53,900,000 62,600,000 62,400,000 42,600,000 30,000,000 30,500,000 31,500,000 27,000,000 16,500,000 20,400,000 21,700,000 19,900,000 16,600,000 13,300,000 15,700,000 17,000,000 9,200,000 9,800,000 8,700,000 7,500,000 6,800,000 4,000,000 5,000,000 3,800,000 3,900,000 2,800,000 4,000,000 3,500,000 3,400,000 2,500,000 2,800,000 2,200,000 2,000,000 2,688,000 2,527,000 2,051,000 1,781,000 2,457,000 3,011,000 2,304,000 2,690,000 1,460,000 1,614,000 1,436,000 2,773,000 1,239,000 1,819,000 1,344,000 1,426,000 1,382,000 1,757,000 1,118,000 1,614,000 1,598,000 1,313,907 488,015 
        total current assets
      4,331,700,000 4,033,300,000 5,219,500,000 5,030,200,000 4,553,800,000 4,301,400,000 4,262,800,000 4,848,400,000 4,620,700,000 4,425,900,000 4,698,400,000 5,002,900,000 3,767,400,000 3,668,800,000 3,398,500,000 3,808,700,000 3,746,600,000 3,684,400,000 3,656,200,000 3,474,200,000 3,445,100,000 3,424,800,000 3,237,100,000 3,033,000,000 1,995,700,000 1,969,400,000 1,815,700,000 1,744,200,000 1,690,800,000 1,699,500,000 914,100,000 836,000,000 729,300,000 744,700,000 692,900,000 656,800,000 330,500,000 280,000,000 258,600,000 241,000,000 227,400,000 231,300,000 203,700,000 170,400,000 146,200,000 145,900,000 123,400,000 105,500,000 93,600,000 93,100,000 81,700,000 74,200,000 71,300,000 77,600,000 75,571,000 83,993,000 92,822,000 104,410,000 115,232,000 123,980,000 54,432,000 66,025,000 44,488,000 50,443,000 59,009,000 36,920,000 43,376,000 54,123,000 66,506,000 32,058,000 29,784,000 42,955,000 53,847,000 67,291,000 77,083,000 57,355,923 51,012,767 
        property and equipment
      1,559,700,000 1,559,900,000 1,471,300,000 1,457,300,000 1,364,700,000 1,339,900,000 1,318,800,000 1,183,100,000 1,108,600,000 1,113,100,000 1,078,900,000 1,077,600,000 1,075,500,000 1,055,600,000 1,002,500,000 942,900,000 856,500,000 801,800,000 742,200,000 676,000,000 589,900,000 515,300,000 461,800,000 384,300,000 346,100,000 321,300,000 301,000,000 253,200,000 221,400,000 183,100,000 169,600,000 156,800,000 152,400,000 145,600,000 136,100,000 125,000,000 123,400,000 109,400,000 88,400,000 77,000,000 65,900,000 54,700,000 46,600,000 40,600,000 35,700,000 31,200,000 28,000,000 26,000,000 22,900,000 20,700,000 19,700,000 19,100,000 18,300,000 18,900,000 18,613,000 17,768,000 16,206,000 15,019,000 12,524,000 12,016,000 11,748,000 10,763,000 9,240,000 7,775,000 6,880,000 6,422,000 6,731,000 6,495,000 6,403,000 6,105,000 6,442,000 6,543,000 6,854,000 6,649,000 5,058,000 6,117,685 5,463,491 
        operating lease right-of-use assets
      73,100,000 77,400,000 54,000,000 56,400,000 59,100,000 62,800,000 67,500,000 71,200,000 68,000,000 71,400,000 73,400,000 76,300,000 78,000,000 80,000,000 73,100,000 77,900,000 82,300,000 88,100,000 91,300,000 94,800,000 98,800,000 93,300,000 94,300,000 71,600,000 73,800,000 71,500,000 34,600,000 35,800,000 27,700,000                                                 
        goodwill
      24,200,000 24,200,000 24,100,000 24,100,000 23,100,000 22,800,000 23,800,000 23,300,000 23,200,000 25,200,000 25,300,000 25,800,000 25,700,000 25,700,000 24,700,000 25,600,000 26,600,000 26,500,000 23,900,000 19,100,000 18,900,000 19,300,000 19,000,000 18,700,000 18,600,000 18,600,000 18,400,000 18,700,000 18,600,000 18,700,000 18,400,000 11,900,000 12,300,000 12,100,000 12,000,000 11,900,000 11,400,000 11,300,000 11,800,000 11,800,000 3,700,000 3,700,000 3,700,000 3,700,000 3,200,000 3,200,000 3,200,000 3,200,000 3,200,000 3,200,000 3,200,000 3,200,000 3,200,000 3,200,000 3,162,000 3,162,000 3,162,000                     
        intangibles
      62,600,000 70,800,000 79,000,000 87,200,000 95,200,000 103,400,000 106,200,000 114,500,000 123,300,000 134,500,000 144,500,000 154,200,000 163,600,000 173,300,000 24,400,000 28,000,000 31,400,000                                                             
        deferred tax assets
      296,100,000 295,600,000 375,600,000 496,300,000 487,300,000 481,200,000 486,500,000 475,800,000 460,700,000 419,400,000 501,300,000 417,000,000 349,100,000 341,200,000 342,300,000 309,500,000 290,800,000 220,800,000 216,300,000 216,400,000 216,700,000 216,400,000                                                        
        other assets
      285,900,000 278,700,000 276,500,000 175,500,000 168,500,000 173,000,000 88,200,000 82,900,000 77,700,000 75,000,000 74,400,000 66,900,000 56,600,000 47,100,000 33,700,000 24,800,000 22,800,000   23,300,000 20,400,000 21,400,000 21,000,000 14,200,000 13,700,000 14,200,000 16,000,000 14,000,000 15,500,000 14,700,000 12,200,000 2,800,000 2,800,000 1,700,000 1,900,000 1,900,000 1,900,000 1,900,000 1,500,000 1,200,000 400,000 100,000 300,000 500,000 600,000 600,000 700,000 700,000 800,000 900,000 800,000 900,000 1,000,000 1,100,000 98,000 98,000 123,000 107,000 98,000 98,000 100,000 101,000 102,000 183,000 236,000 1,192,000 1,210,000 1,275,000 1,335,000 1,933,000 2,010,000 2,147,000 2,284,000 2,405,000 3,348,000   
        total assets
      6,633,300,000 6,339,900,000 7,500,000,000 7,327,000,000 6,751,700,000 6,484,500,000 6,353,800,000 6,799,200,000 6,482,200,000 6,264,500,000 6,596,200,000 6,820,700,000 5,515,900,000 5,391,700,000 4,899,200,000 5,217,400,000 5,057,000,000 4,863,600,000 4,775,900,000 4,503,800,000 4,389,800,000 4,290,500,000 3,833,200,000 3,521,800,000 2,447,900,000 2,395,000,000 2,185,700,000 2,065,900,000 1,974,000,000 1,916,000,000 1,114,300,000 1,007,500,000 896,800,000 904,100,000 842,900,000 795,600,000 467,200,000 402,800,000 361,900,000 332,800,000 299,400,000 292,000,000 256,700,000 218,400,000 189,300,000 184,600,000 159,400,000 139,700,000 124,900,000 122,500,000 110,100,000 102,300,000 98,800,000 106,000,000 102,796,000 110,522,000 117,962,000 120,475,000 128,793,000 136,369,000 66,555,000 77,164,000 54,105,000 60,565,000 68,314,000 46,948,000 53,956,000 65,101,000 77,946,000 44,366,000 43,075,000 57,053,000 68,962,000 77,259,000 85,489,000 64,552,608 56,726,258 
        liabilities and stockholders’ equity
                                                                                   
        current liabilities:
                                                                                   
        accounts payable and accrued liabilities
      2,073,900,000 1,944,000,000 1,932,400,000 1,943,800,000 1,690,600,000 1,585,100,000 1,592,500,000 1,569,800,000 1,446,600,000 1,345,500,000 1,373,100,000 1,156,500,000 965,200,000 901,800,000 764,200,000 688,300,000 603,100,000 573,000,000 598,000,000 482,000,000 502,600,000 481,100,000 397,000,000 315,900,000 267,500,000 256,400,000 232,400,000 196,700,000 169,100,000 147,100,000 135,400,000 117,900,000 88,000,000 87,200,000 80,600,000 72,200,000 65,400,000 68,100,000 58,600,000 49,900,000 45,100,000 38,900,000 34,300,000 24,000,000 21,200,000 20,400,000 20,900,000 20,000,000 15,900,000 14,100,000 12,600,000 9,100,000 7,500,000 8,700,000 10,520,000 7,532,000 7,980,000 6,346,000 6,045,000 4,965,000 4,234,000 5,350,000 7,075,000 5,684,000 5,112,000 5,745,000 4,373,000 4,118,000 3,774,000 4,599,000 2,663,000 3,736,000 3,245,000 4,535,000 2,088,000 2,763,300 6,008,194 
        accrued payroll and related expenses
      121,800,000 169,200,000 170,200,000 129,300,000 110,800,000 112,000,000 105,800,000 116,100,000 110,500,000 171,000,000 151,300,000 108,600,000 94,800,000 134,300,000 112,700,000 94,800,000 84,700,000 125,200,000 115,300,000 98,100,000 81,400,000 114,300,000 92,100,000 67,400,000 59,000,000 88,500,000 70,900,000 73,900,000 51,300,000 72,400,000 55,000,000 46,100,000 34,200,000 48,500,000 35,300,000 31,400,000 30,100,000 33,400,000 27,000,000 23,300,000 16,700,000 24,900,000 20,400,000 17,000,000 12,100,000 17,200,000 16,800,000 13,000,000 11,000,000 15,100,000 12,400,000 10,100,000 7,200,000 9,200,000 8,662,000 7,930,000 6,251,000 6,804,000 6,961,000 6,403,000 4,703,000 5,730,000 5,623,000 4,883,000 4,048,000 4,406,000 3,560,000 3,158,000 2,187,000 2,115,000 2,722,000 2,431,000 2,410,000 2,537,000 2,644,000 1,557,578 889,362 
        short-term operating lease liabilities
      20,500,000 21,600,000 23,600,000 23,400,000 22,600,000 22,500,000 22,300,000 21,600,000 20,700,000 21,100,000 21,000,000 21,800,000 22,200,000 20,500,000 20,900,000 21,200,000 20,900,000 20,500,000 19,300,000 18,800,000 18,200,000 16,500,000 15,800,000                                                       
        other current liabilities
      7,600,000 7,700,000                                                                            
        total current liabilities
      2,223,800,000 2,142,500,000 3,336,000,000 3,308,700,000 3,037,100,000 2,932,000,000 1,734,500,000 1,722,200,000 1,594,200,000 1,556,000,000 1,678,600,000 2,069,700,000 1,865,000,000 1,839,300,000 900,500,000 807,000,000 711,400,000 720,800,000 734,900,000 600,700,000 604,100,000 614,100,000 506,400,000 400,100,000 342,800,000 360,200,000 322,400,000 288,200,000 235,400,000 222,400,000 193,900,000 170,800,000 125,100,000 138,900,000 118,200,000 105,100,000 171,700,000 102,400,000 86,100,000 73,900,000 64,100,000 66,900,000 58,800,000 44,200,000 37,000,000 40,600,000 40,600,000 35,600,000 29,700,000 32,100,000 27,400,000 21,100,000 16,200,000 19,500,000 20,404,000 16,961,000 16,076,000 14,741,000 14,743,000 13,776,000 11,595,000 15,129,000 17,008,000 15,514,000 15,828,000 18,796,000 17,535,000 16,624,000 14,997,000 14,996,000 7,827,000 8,609,000 8,097,000 8,447,000 6,107,000 5,228,678 7,074,096 
        long-term senior convertible notes
      1,241,800,000 1,240,900,000 1,239,900,000 1,238,900,000 1,238,000,000 1,237,000,000 2,439,600,000 2,437,800,000 2,436,000,000 2,434,200,000 2,432,400,000 2,430,600,000 1,198,500,000 1,197,700,000 1,968,800,000 1,967,300,000 1,965,900,000 1,702,700,000 1,703,500,000 1,710,700,000 1,688,800,000 1,667,200,000 1,645,800,000 1,658,800,000 1,072,400,000 1,059,700,000 1,047,100,000 1,034,700,000 1,022,400,000 1,010,300,000                                                
        long-term operating lease liabilities
      69,000,000 73,400,000 50,600,000 54,700,000 59,700,000 65,000,000 71,100,000 76,800,000 75,800,000 80,100,000 83,400,000 86,900,000 89,700,000 94,600,000 82,100,000 87,700,000 93,300,000 98,600,000 102,900,000 107,100,000 111,300,000 101,800,000 103,200,000                                                       
        other long-term liabilities
      141,800,000 137,100,000 147,400,000 151,600,000 150,300,000 147,900,000 129,600,000 128,100,000 129,400,000 125,600,000 133,900,000 133,100,000 129,700,000 128,300,000 123,300,000 99,500,000 97,100,000 90,000,000 98,500,000 87,700,000 82,400,000 80,900,000 78,500,000 35,300,000 20,900,000 20,100,000 17,600,000 17,500,000 18,100,000                                              683,000   
        total liabilities
      3,676,400,000 3,593,900,000 4,773,900,000 4,753,900,000 4,485,100,000 4,381,900,000 4,374,800,000 4,364,900,000 4,235,400,000 4,195,900,000 4,328,300,000 4,720,300,000 3,282,900,000 3,259,900,000 3,074,700,000 2,961,500,000 2,867,700,000 2,612,100,000 2,639,800,000 2,506,200,000 2,486,600,000 2,464,000,000 2,333,900,000 2,167,900,000 1,513,400,000 1,512,400,000 1,421,400,000 1,377,600,000 1,305,400,000 1,252,700,000 552,100,000 525,400,000 475,100,000 484,700,000 458,900,000 441,900,000 189,400,000 119,000,000 100,100,000 86,400,000 68,200,000 70,800,000 63,400,000 47,700,000 40,700,000 44,400,000 44,400,000 40,100,000 34,900,000 38,400,000 35,400,000 30,000,000 25,200,000 29,000,000 22,543,000 19,214,000 18,411,000 15,985,000 15,728,000 14,794,000 13,193,000 16,171,000 18,861,000 19,547,000 21,587,000 65,393,000 63,057,000 63,124,000 62,792,000 82,979,000 70,368,000 71,761,000 71,854,000     
        commitments and contingencies
                                                                                   
        stockholders’ equity:
                                                                                   
        preferred stock, 0.001 par value...
                                                                                   
        common stock, 0.001 par value...
      400,000 400,000 400,000 400,000 400,000 400,000 400,000 400,000 400,000 400,000 400,000 400,000 400,000 400,000 400,000 400,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000  70,000 69,000 69,000  68,000 68,000 63,000  60,000 58,000 58,000  46,000 46,000 46,000  30,000 30,000 30,000 29,000 28,000 28,164 25,417 
        additional paid-in capital
      2,337,500,000 2,281,500,000 2,246,500,000 2,187,500,000 2,142,200,000 2,093,800,000 2,050,500,000 1,992,300,000 2,510,600,000 3,514,600,000 3,618,000,000 2,269,000,000 2,305,600,000 2,258,100,000 2,072,100,000 2,028,900,000 1,996,600,000 2,504,500,000 2,322,100,000 2,193,600,000 2,162,000,000 2,125,300,000 2,153,700,000 2,079,800,000 1,706,500,000 1,675,900,000 1,651,600,000 1,620,400,000 1,590,600,000 1,560,600,000 1,181,600,000 1,149,100,000 1,122,500,000 1,093,700,000 1,048,500,000 1,015,600,000 942,300,000 905,700,000 876,000,000 841,800,000 806,000,000 776,800,000 750,400,000 685,300,000 659,500,000 638,000,000 614,100,000 593,600,000 577,900,000 559,500,000 547,500,000 539,100,000 530,300,000 522,600,000 517,418,000 511,206,000 504,773,000 495,626,000 491,964,000 487,203,000 411,610,000 407,375,000 371,789,000 364,133,000 358,190,000 272,730,000 270,496,000 268,024,000 265,921,000 192,743,000 190,744,000 188,605,000 186,249,000 183,325,000 181,285,000 187,162,062 134,257,379 
        accumulated other comprehensive income
      106,200,000 115,000,000 81,500,000 83,600,000 2,200,000  63,400,000       -11,600,000 -41,100,000 -23,000,000 -6,100,000 500,000 1,400,000 2,800,000 2,900,000 3,200,000 2,800,000 3,500,000 3,700,000 2,300,000 1,000,000 2,000,000 1,600,000 1,500,000                                    -13,000 36,000 63,000 13,000 50,000 -81,000 -45,000 53,000 13,000 34,000 11,923  
        retained earnings
      2,633,400,000 2,433,900,000 2,166,600,000 1,882,800,000 1,703,000,000 1,597,600,000 1,445,900,000 1,311,300,000 1,167,800,000 1,021,400,000 765,100,000 644,400,000 528,500,000 479,900,000 388,100,000 286,900,000 236,000,000                                                             
        treasury stock
      -2,120,600,000 -2,084,800,000 -1,768,900,000 -1,581,200,000 -1,581,200,000 -1,581,200,000 -1,581,200,000 -831,700,000 -1,394,700,000 -2,451,100,000 -2,080,000,000 -784,100,000 -595,000,000 -595,000,000 -595,000,000 -37,300,000 -37,300,000 -206,200,000 -159,500,000 -100,000,000 -100,000,000 -100,000,000 -100,000,000 -100,000,000 -100,000,000 -100,000,000 -100,000,000 -100,000,000 -100,000,000 -100,000,000                                                
        total stockholders’ equity
      2,956,900,000 2,746,000,000 2,726,100,000 2,573,100,000 2,266,600,000 2,102,600,000 1,979,000,000 2,434,300,000 2,246,800,000 2,068,600,000 2,267,900,000 2,100,400,000 2,233,000,000 2,131,800,000 1,824,500,000 2,255,900,000 2,189,300,000 2,251,500,000 2,136,100,000 1,997,600,000 1,903,200,000 1,826,500,000 1,499,300,000 1,353,900,000 934,500,000 882,600,000 764,300,000 688,300,000 668,600,000 663,300,000 562,200,000 482,100,000 421,700,000 419,400,000 384,000,000 353,700,000 277,800,000 283,800,000 261,800,000 246,400,000 231,200,000 221,200,000 193,300,000 170,700,000 148,600,000 140,200,000 115,000,000 99,600,000 90,000,000 84,100,000 74,700,000 72,300,000 73,600,000 77,000,000 80,253,000 91,308,000 99,551,000 104,490,000 113,065,000 121,575,000 53,362,000 60,993,000 35,244,000 41,018,000 46,727,000   1,977,000 15,154,000     7,115,000 17,324,000 56,828,267 49,412,063 
        total liabilities and stockholders’ equity
      6,633,300,000 6,339,900,000 7,500,000,000 7,327,000,000 6,751,700,000 6,484,500,000 6,353,800,000 6,799,200,000 6,482,200,000 6,264,500,000 6,596,200,000 6,820,700,000 5,515,900,000 5,391,700,000 4,899,200,000 5,217,400,000 5,057,000,000 4,863,600,000 4,775,900,000 4,503,800,000 4,389,800,000 4,290,500,000 3,833,200,000 3,521,800,000 2,447,900,000 2,395,000,000 2,185,700,000 2,065,900,000 1,974,000,000 1,916,000,000 1,114,300,000 1,007,500,000 896,800,000 904,100,000 842,900,000 795,600,000 467,200,000 402,800,000 361,900,000 332,800,000 299,400,000 292,000,000 256,700,000 218,400,000 189,300,000 184,600,000 159,400,000 139,700,000 124,900,000 122,500,000 110,100,000 102,300,000 98,800,000 106,000,000 102,796,000 110,522,000 117,962,000 120,475,000 128,793,000 136,369,000 66,555,000 77,164,000 54,105,000 60,565,000 68,314,000   65,101,000 77,946,000   57,053,000 68,962,000 77,259,000 85,489,000 64,552,608  
        current portion of long-term senior convertible notes
        1,206,900,000 1,206,100,000 1,205,300,000 1,204,400,000     124,200,000 773,800,000 773,200,000 772,600,000                                                                
        deferred revenue
        2,900,000 6,100,000 7,800,000 8,000,000 13,900,000 14,700,000 16,400,000 18,400,000 9,000,000 9,000,000 9,600,000 10,100,000 2,700,000 2,700,000 2,700,000 2,100,000 2,300,000 1,800,000 1,900,000 2,200,000 1,500,000 1,700,000 1,800,000 1,700,000 4,300,000 3,500,000 2,700,000 2,900,000 3,500,000 6,800,000 2,900,000 3,200,000                                            
        accumulated other comprehensive loss
           -8,000,000  -38,000,000 -37,300,000 -16,700,000 -35,600,000 -29,300,000 -6,500,000                  -300,000 -1,300,000 -4,900,000 -2,600,000 -2,200,000 -1,600,000 -1,300,000 -1,000,000 -700,000 -700,000 -300,000 -300,000 -300,000 -300,000 -300,000 -100,000 -100,000 -200,000 -100,000 -100,000 -100,000 -100,000 -100,000 -100,000 -93,000 -88,000 -103,000 -80,000 -94,000 -101,000 -83,000 -66,000 -39,000 -5,000 -40,000             
        * we adjusted our 2021 amounts to reflect the simplified convertible instruments accounting guidance, which we adopted on a full retrospective basis. all periods presented have also been adjusted to reflect the four-for-one stock split. refer to note 1, “organization and significant accounting policies,” to the consolidated financial statements for further information.
                                                                                   
        * we adjusted our 2021 amounts to reflect the simplified convertible instruments accounting guidance, which we adopted on a full retrospective basis. all periods presented have also been adjusted to reflect the four-for-one stock split. refer to note 1, “organization and significant accounting policies,” for further information.
                                                                                   
        * we adjusted our 2021 amounts to reflect the simplified convertible instruments accounting guidance, which we adopted on a full retrospective basis. refer to note 1 “organization and significant accounting policies” for further information.
                                                                                   
        intangibles and other assets
                       42,000,000 46,000,000                                                           
        accumulated deficit
                       -47,400,000 -28,000,000 -98,900,000 -161,800,000 -202,100,000 -557,300,000 -629,500,000 -675,800,000 -695,700,000 -788,400,000 -834,200,000 -823,700,000 -798,900,000 -619,200,000 -665,800,000 -696,000,000 -671,800,000 -662,400,000 -660,400,000 -663,300,000 -621,000,000 -613,600,000 -594,800,000 -574,600,000 -555,400,000 -556,900,000 -514,400,000 -510,700,000 -497,800,000 -499,100,000 -493,900,000 -487,900,000 -475,400,000 -472,800,000 -466,800,000 -456,700,000 -445,600,000 -437,142,000 -419,879,000 -405,188,000 -391,124,000 -378,873,000 -365,595,000 -358,228,000 -346,378,000 -336,566,000 -323,168,000 -311,481,000 -291,208,000 -279,679,000 -266,156,000 -250,826,000 -231,436,000 -217,986,000 -203,298,000 -189,224,000 -176,252,000    
        operating lease liabilities, current portion
                             15,100,000 14,500,000 13,600,000 14,800,000 14,100,000 12,300,000                                                 
        operating lease liabilities, net of current portion
                             73,700,000 77,300,000 72,400,000 34,300,000 37,200,000 29,500,000                                                 
        other liabilities
                                   20,000,000 19,400,000 19,600,000 18,700,000 18,200,000 16,700,000 16,300,000 17,700,000 16,600,000 14,000,000 12,500,000 4,100,000 3,900,000 4,200,000 2,400,000 2,000,000 1,500,000 900,000 1,000,000 1,100,000 1,700,000 2,800,000 3,100,000 2,700,000 2,100,000 1,570,000 1,551,000 1,501,000 963,000 985,000 1,018,000 1,027,000 1,042,000 972,000 750,000 791,000 840,000 839,000 880,000 916,000 889,000 679,000 679,000 673,000 666,000    
        long term senior convertible notes
                                    338,800,000 335,000,000 331,300,000 327,600,000 324,000,000 320,500,000                                          
        short-term marketable securities, available-for-sale
                                       107,100,000 123,700,000 100,700,000 27,600,000 29,200,000 29,600,000 28,100,000 28,600,000 29,100,000 28,000,000 29,800,000 29,600,000 11,800,000 11,700,000 11,800,000 11,700,000 11,400,000 14,200,000 18,200,000 26,400,000 40,600,000 48,641,000 55,203,000 65,065,000 79,358,000 79,794,000 71,139,000 33,526,000 42,224,000 24,380,000 33,991,000 39,221,000 24,439,000 31,356,000 44,666,000 52,176,000 14,368,000 20,741,000 32,896,000 26,632,000 41,208,000 59,103,000 36,341,449 13,277,688 
        current portion of deferred revenue
                                        2,300,000 1,500,000 1,200,000 900,000 500,000 700,000 600,000 800,000 1,600,000 800,000 1,300,000 700,000 600,000 300,000 600,000 700,000 600,000 700,000 800,000 1,400,000 1,222,000 1,499,000 1,845,000 1,591,000 1,737,000 2,333,000 2,358,000 3,524,000 3,560,000 4,047,000 5,768,000 7,745,000 8,702,000 8,104,000 7,448,000 6,351,000 167,000 167,000 167,000     
        short-term borrowings
                                          75,000,000                                         
        intangible assets
                                           200,000 1,600,000 1,800,000 2,000,000 2,200,000 2,400,000 2,500,000 2,600,000 2,700,000 3,100,000 3,300,000 3,400,000 3,600,000 3,700,000 3,900,000 4,000,000 4,200,000 4,313,000 4,462,000 4,610,000                     
        current portion of long-term debt
                                              1,700,000 2,300,000 2,500,000 2,400,000 2,400,000 2,300,000 2,300,000 2,300,000 2,200,000 2,200,000 1,800,000 1,200,000 700,000 200,000      75,000 300,000 525,000 750,000 900,000 900,000 900,000 900,000 1,244,000 1,588,000 1,931,000 2,275,000 2,275,000 2,275,000 1,375,000 1,375,000 907,800  
        restricted cash
                                                 700,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,039,000 1,039,000 1,039,000 939,000 939,000 989,000 1,214,000 1,439,000 1,664,000 2,164,000 2,189,000 2,414,000 2,639,000 3,208,000 3,702,000 4,270,000 4,839,000 5,408,000 5,977,000 914,000  1,079,000 250,000 
        long-term debt
                                                400,000 1,100,000 1,700,000 2,300,000 2,900,000 3,500,000 4,100,000 4,600,000 5,200,000 5,800,000 6,300,000 6,800,000          3,283,000 4,968,000 45,757,000 44,683,000 43,667,000 42,706,000 61,425,000 61,650,000 62,219,000 62,788,000 61,031,000 61,375,000 2,118,200  
        long-term portion of deferred revenue
                                                           600,000 569,000 702,000 834,000 281,000   571,000  881,000     1,953,000 4,173,000 5,669,000 212,000 254,000 296,000     
        preferred stock, 0.001 par value per share...
                                                                                   
        common stock, 0.001 par value per share...
                                                           100,000    68,000    62,000    46,000    30,000        
        stockholders’ equity
                                                                                   
        stockholders’ deficit:
                                                                                   
        total stockholders’ deficit
                                                                       -18,445,000 -9,101,000           
        total liabilities and stockholders’ deficit
                                                                       46,948,000 53,956,000           
        stockholders’ (deficit) equity:
                                                                                   
        total stockholders’ (deficit) equity
                                                                           -38,613,000 -27,293,000 -14,708,000 -2,892,000     
        total liabilities and stockholders’ (deficit) equity
                                                                           44,366,000 43,075,000       
        deferred rent
                                                                                 377,463 240,099 
        deferred stock-based compensation
                                                                                   
        deferred offering costs and other assets
                                                                                   
        liabilities, redeemable convertible preferred stock and stockholders’ equity
                                                                                   
        accrued clinical trials
                                                                                  176,540 
        redeemable convertible series b preferred stock, 0.001 par value...
                                                                                   
        redeemable convertible series c preferred stock, 0.001 par value...
                                                                                   
        redeemable convertible series d preferred stock, 0.001 par value...
                                                                                   
        convertible series a preferred stock, 0.001 par value...
                                                                                   
        deficit accumulated during the development stage
                                                                                   
        total liabilities, redeemable convertible preferred stock and stockholders’ equity
                                                                                  56,726,258 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 
                                                                                
          operating activities
                                                                                
          net income
        199,500,000 267,300,000 283,800,000 179,800,000 105,400,000 151,700,000 134,600,000 143,500,000 146,400,000 256,300,000 120,700,000 115,900,000 48,600,000 91,800,000 101,200,000 50,900,000 97,300,000 -19,400,000 70,900,000 62,900,000 40,300,000 355,200,000 72,200,000 46,300,000 19,900,000 92,700,000 45,800,000 -10,500,000 -26,900,000 -179,700,000 46,600,000 30,200,000 -24,200,000 -2,000,000 2,900,000 -41,700,000 -7,400,000 -18,800,000 -20,200,000 -19,200,000 1,500,000 -42,500,000 -3,700,000 -12,900,000 -5,200,000 -6,000,000 -12,500,000 -2,600,000 -6,000,000 -10,100,000 -11,100,000 -8,482,000 -17,263,000 -14,691,000 -14,064,000 -12,251,000 -13,278,000 -7,367,000 -11,850,000 -9,812,000 -13,398,000 -11,687,000 -20,273,000 -11,529,000 -13,523,000 -15,330,000 -13,142,000 -13,450,000 -14,688,000 -14,074,000 -12,972,000 -12,229,000 
          adjustments to reconcile net income to cash from operating activities:
                                                                                
          depreciation and amortization
        67,100,000 65,200,000 63,600,000 63,000,000 60,000,000 57,800,000 55,300,000 52,100,000 52,500,000 52,500,000 48,200,000 43,700,000 41,600,000 36,300,000 39,200,000 43,600,000 36,800,000 32,100,000 25,500,000 23,500,000 20,900,000 20,400,000 18,400,000 15,300,000 13,000,000 14,300,000 12,900,000 11,600,000 9,900,000 8,600,000 7,800,000 6,700,000 6,000,000 4,300,000 3,900,000 3,700,000 3,600,000 4,100,000 3,900,000 3,400,000 3,100,000 2,700,000 2,600,000 2,400,000 2,200,000 1,900,000 1,900,000 1,900,000 1,700,000 1,600,000 1,800,000 1,751,000 2,199,000 1,468,000 1,182,000 1,063,000 998,000 892,000 806,000 721,000 628,000 588,000 500,000 470,000 589,000 662,000 652,000 768,000 710,000 703,000 855,000 1,004,000 
          share-based compensation
        43,300,000 35,000,000 45,100,000 45,300,000 34,200,000 43,300,000 43,400,000 44,700,000 39,000,000 36,900,000 39,000,000 39,700,000 35,200,000 34,000,000 30,800,000 32,600,000 29,100,000 26,300,000 27,500,000 31,600,000 28,000,000 34,100,000 30,700,000 30,700,000 23,900,000 23,600,000 24,400,000 29,700,000 25,000,000 24,600,000 27,100,000 25,600,000 24,600,000 25,400,000 25,300,000 30,600,000 29,100,000 29,000,000 27,600,000 25,100,000 23,500,000 22,600,000 20,700,000 15,900,000 13,800,000 13,200,000 8,700,000 6,600,000 6,600,000 6,400,000 5,000,000 4,542,000 4,879,000 4,833,000 4,146,000 3,580,000 3,728,000 3,657,000 2,548,000 2,078,000 2,317,000 2,771,000 2,275,000 2,154,000 2,130,000 2,041,000 2,041,000  1,787,000 1,972,000 1,948,000  
          non-cash interest expense
        1,000,000 1,700,000 1,900,000 1,800,000 1,900,000 1,900,000 1,900,000 1,800,000 1,900,000 2,000,000 2,200,000 2,100,000 1,500,000 1,600,000 1,500,000 1,600,000 1,600,000 22,000,000 22,000,000 22,500,000 22,200,000 22,000,000 21,700,000 17,600,000 12,700,000 12,600,000 12,500,000 12,300,000 12,200,000 6,600,000 3,800,000 3,800,000 3,700,000 3,600,000                                       
          deferred income taxes
        300,000 78,900,000 118,000,000 -8,900,000 -5,800,000 24,300,000 -11,600,000 -14,700,000 -41,800,000 81,500,000 -85,000,000 -42,200,000 -9,300,000 32,000,000 -33,800,000 -19,900,000 100,000 -5,100,000 100,000 400,000 -300,000                                                    
          net losses on equity investments
                                                                               
          other non-cash income and expenses
         -3,100,000 -6,000,000 -400,000 -12,300,000 16,000,000 -39,900,000 -15,600,000 -7,800,000 -36,600,000 -17,900,000 -15,700,000 -13,700,000 2,800,000 15,900,000 12,200,000 3,800,000 13,100,000 14,500,000 8,000,000 8,000,000 9,600,000 600,000 3,400,000 100,000 1,500,000 2,500,000 -2,200,000 300,000 -300,000 300,000 5,600,000 -900,000                                        
          changes in operating assets and liabilities:
                                                                                
          accounts receivable
        124,600,000 -106,200,000 237,800,000 -184,600,000 -148,900,000 -7,400,000 -55,600,000 33,800,000 -5,800,000 -187,200,000 -35,800,000 -113,700,000 76,600,000 -148,300,000 -4,500,000 -17,000,000 -30,100,000 15,100,000 -35,700,000 -40,000,000 -14,900,000 -58,500,000 -73,400,000 4,300,000 -14,700,000 -50,800,000 -18,400,000 -12,300,000 21,500,000 -57,000,000 -8,100,000 -38,800,000 10,700,000 -8,700,000 -15,300,000 15,800,000 -25,000,000 -3,000,000 -6,000,000 6,800,000 -18,300,000 -10,300,000 -5,300,000 2,200,000 -2,800,000 -4,700,000 2,200,000 -4,500,000 -3,800,000 -1,400,000 3,200,000 -7,190,000 543,000 -357,000 4,000 -3,544,000 -309,000 -1,536,000 -487,000 -1,569,000 -441,000 -860,000 -311,000 -1,003,000 -420,000 -722,000 -227,000 -689,000 139,000 -247,000 -106,000  
          inventory
        -65,200,000 -17,800,000 -33,600,000 -18,500,000 6,200,000 32,700,000 -1,900,000 18,300,000 -36,700,000 -59,000,000 -78,600,000 -55,400,000 -59,600,000 5,700,000 26,900,000 1,100,000 15,600,000 -6,000,000 -21,700,000 -29,500,000 -55,000,000 -33,600,000 -35,400,000 -23,300,000 -22,200,000 600,000 -2,500,000 -16,800,000 -30,400,000 -15,500,000 -9,000,000 5,400,000 -6,400,000 -600,000 3,800,000 -1,000,000 -900,000 -1,700,000 3,700,000 -10,900,000 -4,600,000 -8,200,000 -4,000,000 -2,400,000 -2,700,000 -2,800,000 200,000 900,000 -2,700,000 300,000 -100,000 -330,000 237,000 666,000 127,000 -1,716,000 -197,000 167,000 1,687,000 -1,759,000 -2,266,000 -236,000 -1,210,000 -709,000 -569,000 1,002,000 81,000 144,000 181,000 -947,000 -685,000 -104,000 
          prepaid and other assets
        51,000,000 -6,900,000 -2,400,000 -22,000,000 16,500,000 8,000,000 31,600,000 -56,800,000 11,400,000 6,100,000 16,600,000 10,000,000 -13,400,000 -50,400,000 1,300,000 15,400,000 -97,900,000 -3,100,000 8,900,000 -6,900,000 -20,200,000 9,400,000 14,800,000 -19,000,000 -7,600,000 -4,600,000 800,000 2,000,000 -5,400,000 400,000 1,600,000 -2,300,000 -2,700,000 2,500,000 1,500,000 -7,700,000 200,000 -1,400,000 -1,700,000 -1,000,000   -1,200,000 200,000 1,300,000   -900,000 300,000 -700,000 -100,000 -18,000 -139,000 -412,000 -231,000 720,000 689,000 -560,000 389,000 -1,133,000 162,000 -136,000 2,395,000 -1,539,000 696,000 -563,000 402,000 -133,000 337,000 -478,000 422,000 -36,000 
          operating lease right-of-use assets and liabilities
        -1,300,000 -2,600,000 -1,500,000 -2,100,000 -900,000 -3,500,000 600,000 -1,600,000 -2,000,000 -100,000 -2,300,000 -1,400,000 -700,000 300,000 -2,700,000 -2,500,000 -900,000 -1,200,000 400,000 700,000 500,000 -100,000 -800,000 -400,000                                                
          accounts payable and accrued liabilities
        145,100,000 -10,100,000 -2,300,000 234,000,000 125,400,000 -20,000,000 49,800,000 72,300,000 109,600,000 -30,000,000 219,500,000 190,300,000 86,700,000 123,800,000 75,300,000 42,500,000 53,500,000 -57,300,000   30,000,000 67,900,000 69,800,000 51,500,000 5,300,000 30,800,000 24,300,000 28,400,000 25,500,000 6,000,000 17,300,000 30,700,000 2,200,000 10,700,000 -300,000 2,100,000 2,500,000 9,300,000 5,600,000 3,700,000 5,000,000 9,100,000 2,100,000 1,600,000 1,700,000 4,500,000 -100,000 -500,000 2,100,000 1,300,000 -500,000 -2,066,000 2,817,000 180,000 -631,000 301,000 1,080,000 731,000 -1,116,000 -1,728,000 1,387,000 572,000 -663,000 1,372,000 255,000 344,000 -463,000 1,581,000 -1,060,000 491,000 -1,303,000  
          accrued payroll and related expenses
        -47,100,000 -1,200,000 41,300,000 15,900,000 -600,000 4,300,000 -9,100,000 5,500,000 -60,700,000 20,600,000 42,100,000 13,800,000 -39,300,000 22,500,000 17,100,000 9,400,000 -40,500,000 9,900,000 16,700,000 16,800,000 -33,000,000 21,800,000 25,100,000 8,300,000 -29,100,000 17,200,000 -2,800,000 22,700,000 -21,100,000 17,600,000 8,200,000 12,400,000 -14,400,000 3,700,000 1,200,000 -3,300,000 6,500,000 3,700,000 6,500,000 -8,200,000 4,600,000 3,300,000 4,900,000 -5,100,000 3,700,000 2,000,000 -4,000,000 2,700,000 2,300,000 2,800,000 -2,000,000 542,000 732,000 1,679,000 -553,000 -157,000 558,000 1,700,000 -1,027,000 107,000 740,000 835,000 -358,000 846,000 402,000 971,000 72,000 -607,000 291,000 21,000 -127,000 -107,000 
          deferred revenue and other liabilities
        7,300,000 -6,200,000 -7,700,000 -300,000 2,700,000 -7,700,000 400,000 -3,900,000 3,200,000 -8,500,000 1,500,000 3,200,000 1,200,000 -19,600,000 25,000,000 2,900,000 2,800,000 2,000,000 3,700,000 1,900,000 1,100,000 1,900,000 1,300,000 14,400,000 1,000,000  -5,000,000                                              
          net cash from operating activities
        525,600,000 294,000,000 659,900,000 303,000,000 183,800,000 301,400,000 199,500,000 279,400,000 209,200,000 133,600,000 269,200,000 190,300,000 155,400,000 132,500,000 293,200,000 172,800,000 71,000,000 105,800,000 247,300,000 61,600,000 27,800,000 172,000,000 147,600,000 154,100,000 1,900,000 143,700,000 94,500,000 64,500,000 11,800,000 33,700,000 56,800,000 41,400,000 -8,700,000 36,200,000 14,300,000 300,000 13,300,000 23,000,000 20,100,000 -200,000 11,300,000 17,900,000 16,400,000 3,400,000 11,400,000 6,200,000 -2,400,000 4,400,000 1,600,000 900,000 -4,500,000 -10,557,000 -6,050,000 -6,329,000 -10,164,000 -11,570,000 -6,741,000 -2,526,000 -9,289,000 -13,464,000 -9,470,000 -9,305,000 -10,437,000 -9,173,000 -9,808,000 -11,036,000 -9,372,000 2,526,000 -11,617,000 -11,901,000 -16,459,000  
          capital expenditures
        -26,200,000 -101,900,000 -85,800,000 -100,000,000 -29,400,000 -124,600,000 -124,300,000 -16,100,000 -16,200,000 -52,500,000 -56,800,000 -61,400,000 -18,900,000 -63,500,000 -108,200,000 -91,500,000 -75,000,000 -80,200,000 -121,100,000 -93,000,000 -64,700,000 -60,200,000 -36,600,000 -60,800,000 -13,600,000 15,200,000 -49,900,000 -29,200,000 -17,700,000 -27,100,000 -8,300,000 -11,000,000 -11,900,000 -12,700,000 -17,300,000 -17,600,000 -16,100,000 -10,500,000 -11,500,000 -11,600,000 -7,400,000 -6,300,000 -8,000,000 -3,700,000 -4,000,000 -3,900,000 -2,300,000 -2,200,000 -2,000,000 -1,400,000 -1,404,000 -2,894,000 -2,882,000 -2,320,000 -3,549,000 -1,506,000 -1,160,000 -1,791,000 -2,326,000 -2,093,000 -1,483,000 -958,000 -463,000 -825,000 -754,000 -950,000 -431,000 -609,000 -392,000 -1,060,000  
          free cash flows
        499,400,000 192,100,000 574,100,000 203,000,000 154,400,000 176,800,000 75,200,000 263,300,000 193,000,000 81,100,000 212,400,000 128,900,000 136,500,000 69,000,000 185,000,000 81,300,000 -4,000,000 25,600,000 126,200,000 -31,400,000 -36,900,000 111,800,000 111,000,000 93,300,000 -11,700,000 143,700,000 109,700,000 14,600,000 -17,400,000 16,000,000 29,700,000 33,100,000 -19,700,000 24,300,000 1,600,000 -17,000,000 -4,300,000 6,900,000 9,600,000 -11,700,000 -300,000 10,500,000 10,100,000 -4,600,000 7,700,000 2,200,000 -6,300,000 2,100,000 -600,000 -1,100,000 -5,900,000 -11,961,000 -8,944,000 -9,211,000 -12,484,000 -15,119,000 -8,247,000 -3,686,000 -11,080,000 -15,790,000 -11,563,000 -10,788,000 -11,395,000 -9,636,000 -10,633,000 -11,790,000 -10,322,000 2,095,000 -12,226,000 -12,293,000 -17,519,000  
          investing activities
                                                                                
          purchases of marketable securities
        -688,600,000 -175,900,000 -608,200,000 -462,500,000  -306,900,000 -784,200,000 -992,400,000  -798,000,000 -1,340,300,000 -809,600,000  -254,000,000 -597,200,000 -546,500,000  -368,300,000 -369,900,000 -802,000,000  -403,100,000 -1,374,200,000 -365,800,000                                                
          proceeds from sale and maturity of marketable securities
        468,200,000 409,600,000 466,200,000 638,700,000 650,200,000 405,200,000 630,600,000 666,800,000 1,121,800,000 719,000,000 671,400,000 859,400,000 697,600,000 740,000,000 602,200,000 543,800,000 241,800,000 501,000,000 537,000,000 838,300,000 790,000,000 952,000,000 449,000,000 319,500,000 530,000,000 423,400,000 259,200,000 291,300,000 222,500,000 161,100,000                                           
          purchases of property and equipment
        -76,600,000 -101,900,000 -80,500,000 -94,100,000 -87,000,000 -124,600,000 -111,200,000 -66,100,000 -56,900,000 -52,500,000 -50,400,000 -59,000,000 -74,700,000 -63,500,000 -108,200,000 -91,500,000 -101,600,000 -80,200,000 -108,100,000 -101,200,000 -99,700,000 -60,200,000 -47,400,000 -58,200,000 -33,200,000                                                
          purchases of non-marketable equity securities
        -1,500,000 -1,200,000                                                                       
          other investing activities
         100,000 1,000,000 -500,000 -10,200,000 -2,200,000 -5,400,000 2,300,000 900,000 -2,500,000   -2,000,000 -10,000,000 -2,300,000 14,600,000 -4,000,000 -500,000 -700,000 -7,800,000 -2,400,000 -400,000                                                
          net cash from investing activities
        -298,500,000 306,600,000 192,800,000 -63,600,000 100,200,000 -303,700,000 210,300,000 -188,900,000 74,800,000 414,900,000 -179,500,000 -555,900,000 -186,700,000 -194,100,000 229,300,000 -144,900,000 -411,800,000 -496,100,000 29,000,000 363,200,000 -112,200,000 -24,000,000 -9,300,000 -1,115,300,000 130,600,000 -94,300,000 -412,800,000 -639,400,000 131,300,000 30,900,000 4,600,000 -159,900,000 -15,400,000 -36,600,000 -85,300,000 -21,400,000 -17,300,000 -17,800,000 -9,600,000 -11,200,000 -12,700,000 -5,700,000 -7,200,000 -25,900,000 -3,800,000 -4,000,000 -4,300,000 500,000 1,700,000 6,100,000 12,600,000 6,553,000 3,494,000 6,722,000 11,631,000 -3,446,000 -10,602,000 -39,099,000 6,776,000 -20,429,000 7,327,000 3,513,000 -16,021,000          
          financing activities
                                                                                
          net proceeds from issuance of common stock
        12,700,000 13,900,000 14,200,000 14,800,000 13,400,000 14,300,000 12,300,000 12,400,000 10,100,000 11,600,000 8,700,000 8,600,000 6,700,000 6,800,000 100,000 5,000,000 200,000 5,400,000 1,000,000 4,200,000 4,300,000 400,000 5,300,000 500,000 5,100,000 1,000,000 3,800,000 2,800,000 5,900,000 4,900,000 5,500,000 6,600,000 2,200,000 9,700,000 5,100,000 1,900,000 2,300,000 2,700,000 694,000 1,334,000 452,000 1,120,000 47,000 1,033,000 71,941,000 1,688,000 33,485,000 1,850,000 1,397,000 33,814,000 79,000 343,000 78,000 45,810,000 66,000 384,000 259,000 1,053,000 207,000 
          payments for taxes related to net share settlement of equity awards
        -35,800,000                                                                        
          other financing activities
        -1,900,000 -1,900,000 -1,700,000 -1,700,000 -1,700,000 -1,600,000 -1,300,000 -1,400,000 -8,700,000 4,900,000 -1,200,000 -1,100,000 -1,100,000 -1,000,000 -7,200,000 -4,300,000 -4,800,000 -800,000 -800,000 -400,000 -7,900,000 -4,900,000 -4,100,000 -200,000 -200,000 -800,000 -100,000 -200,000 -100,000                                            
          net cash from financing activities
        -25,000,000 -1,522,200,000 -175,000,000 -1,700,000 12,500,000 -1,600,000 -736,500,000 -1,400,000 4,700,000 -631,900,000 -637,400,000 939,500,000 11,200,000 -1,000,000 -552,500,000 -4,300,000 5,300,000 -800,000 10,800,000 -400,000 800,000 -4,900,000 4,500,000 906,000,000 6,500,000 -100,000 6,000,000 -100,000 4,900,000 701,600,000 5,400,000 -800,000 4,200,000 4,300,000 314,400,000 80,300,000 500,000 5,100,000 -700,000 3,200,000 2,200,000 5,400,000 4,300,000 4,900,000 6,100,000 1,600,000 9,200,000 4,900,000 1,900,000 2,300,000 2,700,000 7,294,000 1,334,000 452,000 1,120,000 47,000 958,000 71,716,000 1,463,000 33,260,000 1,625,000 1,172,000 33,589,000 -146,000 -226,000 -491,000 45,242,000 -503,000 -185,000 -310,000 3,710,000 -204,000 
          effect of exchange rate changes on cash, cash equivalents and restricted cash
        -2,800,000 3,800,000 -1,100,000 16,500,000 2,300,000 -11,200,000 8,600,000 -1,000,000 -3,800,000 6,100,000 -3,500,000 -2,200,000 1,100,000 6,800,000 -7,300,000 -4,300,000 -1,000,000 -500,000 -1,000,000 500,000 -400,000 1,300,000 1,000,000 300,000 -500,000 1,000,000 -1,400,000 -900,000 600,000 3,200,000 400,000 -900,000 -900,000                                        
          increase in cash, cash equivalents and restricted cash
        199,300,000 -917,800,000 676,600,000 254,200,000 298,800,000 -15,100,000 -318,100,000 88,100,000 284,900,000 -77,300,000 -551,200,000   -55,800,000 -37,300,000   -391,600,000 286,100,000 424,900,000 -84,000,000 144,400,000 143,800,000 -54,900,000 138,500,000    148,600,000 769,400,000 67,200,000 -120,200,000 -20,800,000                                        
          cash, cash equivalents and restricted cash, beginning of period
        919,100,000 607,300,000 567,500,000 643,300,000 1,053,600,000 818,200,000 446,400,000 1,137,100,000 441,500,000                                        
          cash, cash equivalents and restricted cash, end of period
        1,118,400,000 -917,800,000 676,600,000 254,200,000 906,100,000 -15,100,000 -318,100,000 88,100,000 852,400,000 -77,300,000 -551,200,000 571,700,000 624,300,000 -55,800,000 -37,300,000 19,300,000 717,100,000 -391,600,000 286,100,000 424,900,000 734,200,000 144,400,000 143,800,000 -54,900,000 584,900,000 50,300,000 -313,700,000 -575,900,000 1,285,700,000 769,400,000 67,200,000 -120,200,000 420,700,000                                        
          reconciliation of cash, cash equivalents and restricted cash, end of period:
                                                                                
          cash and cash equivalents
        1,118,200,000 -918,000,000 676,700,000 254,100,000 904,900,000 -15,100,000 -318,000,000 88,000,000 851,200,000 -77,400,000 -551,200,000 571,700,000 623,200,000 -55,800,000 -37,300,000 19,400,000 716,000,000 -391,700,000 285,500,000 425,000,000 733,800,000 144,100,000 143,500,000 -54,600,000 584,600,000 50,600,000 -313,600,000 -575,900,000 1,285,100,000 769,600,000                                           
          restricted cash
        200,000 200,000 -100,000 100,000 1,200,000 -100,000 100,000 1,200,000 100,000 1,100,000 -100,000 1,100,000 100,000 600,000 -100,000 400,000 300,000   300,000 -300,000 -100,000 600,000 -200,000 300,000        700,000          -100,000 325,000 225,000 225,000 225,000 225,000 25,000 225,000 225,000 569,000 494,000 568,000 569,000 569,000 569,000 -5,063,000  
          total cash, cash equivalents and restricted cash
        1,118,400,000 -917,800,000 676,600,000 254,200,000 906,100,000 -15,100,000 -318,100,000 88,100,000 852,400,000 -77,300,000 -551,200,000 571,700,000 624,300,000 -55,800,000 -37,300,000 19,300,000 717,100,000 -391,600,000 286,100,000 424,900,000 734,200,000 144,400,000 143,800,000 -54,900,000 584,900,000 50,300,000 -313,700,000 -575,900,000 1,285,700,000 769,400,000                                           
          supplemental disclosure of non-cash investing and financing transactions:
                                                                                
          acquisition of property and equipment included in accounts payable and accrued liabilities
        50,400,000  -5,300,000 -5,900,000 57,600,000  -13,100,000 50,000,000 40,700,000  -6,400,000 -2,400,000 55,800,000    26,600,000  -13,000,000 8,200,000 35,000,000  10,800,000 -2,600,000 19,600,000  15,200,000 -3,000,000 10,100,000  -3,300,000 2,000,000 4,300,000 1,600,000 -700,000 5,600,000                                     
          right-of-use assets obtained in exchange for operating lease liabilities
        400,000  2,200,000    -500,000 7,600,000 1,100,000  1,900,000 2,200,000 1,900,000    -1,300,000  1,800,000 500,000 9,900,000                                                    
          right-of-use assets obtained in exchange for finance lease liabilities
        2,000,000  300,000 1,100,000  2,000,000 2,400,000 7,400,000  300,000 500,000 1,000,000    5,200,000  1,700,000                                                      
          purchases of treasury stock
         -312,800,000       -500,000,000                                                             
          proceeds from issuance of convertible notes, net of issuance costs
                                                                              
          purchases of capped call transactions
                                                                              
          payments for conversions of senior convertible notes
                 -136,800,000                                                               
          repayments for maturity of senior convertible notes
                                                                                
          purchase of marketable securities
                                   -883,800,000 -50,700,000 -112,500,000                                           
          acquisitions, net of cash acquired
                     -700,000 -3,200,000 1,400,000                  -100,000                                 
          proceeds from issuance of senior convertible notes, net of issuance costs
                                                                               
          shares issued for conversions of 2023 notes
                        35,900,000                                                        
          shares received under note hedge upon conversion of 2023 notes
                                                                                
          collaborative research and development fee
                                                                                
          loss on extinguishment of debt
                         700,000    500,000                                                  
          realized loss on equity investment
                 -900,000       -200,000                                                        
          decrease in cash, cash equivalents and restricted cash
                    -19,000,000    -336,500,000          -313,700,000                                              
          realized (gain) loss on equity investment
                                                                              
          repurchase of convertible notes
                                                                              
          shares received under note hedge upon conversions of 2023 notes
                        -33,500,000                                                        
          * we adjusted our 2021 amounts to reflect the simplified convertible instruments accounting guidance, which we adopted on a full retrospective basis. refer to note 1 “organization and significant accounting policies” for further information.
                                                                                
          shares issued for repurchase and conversions of senior convertible notes
                                                                                
          common stock issued for repurchase and conversions of senior convertible notes
                              160,900,000                                                  
          non-cash collaborative research and development fee through issuance of common stock
                                                                                
          unrealized gain on equity investment
                                        -7,400,000                                        
          proceeds from sale of warrants
                                                                                
          purchase of convertible note hedge
                                                                                
          cash flows from investing activities:
                                                                                
          cash flows from financing activities:
                                                                                
          right-of-use assets obtained in exchange for lease liabilities
                               5,300,000  1,400,000 10,600,000 45,200,000                                            
          purchases of other equity investments
                                                                                
          deferred revenue, deferred rent and other liabilities
                                                                                
          purchase of other equity investments
                                   -1,200,000 -1,000,000                                        
          purchase of property and equipment
                                   -46,900,000 -39,300,000 -17,700,000 -23,800,000 -10,300,000 -15,300,000 -13,500,000 -12,000,000 -22,900,000 -17,600,000 -16,100,000 -10,500,000 -11,500,000 -11,600,000 -7,400,000 -6,300,000 -8,000,000 -3,700,000 -4,000,000 -3,900,000 -2,300,000 -2,200,000 -2,000,000 -1,400,000 -1,404,000 -2,894,000 -2,882,000 -2,320,000 -3,549,000 -1,506,000 -1,160,000 -1,791,000 -2,326,000 -2,093,000 -1,483,000 -958,000 -463,000 -825,000 -754,000 -950,000 -431,000 -609,000 -392,000 -1,060,000  
          proceeds from issuance of convertible debt, net of issuance costs
                                                                               
          proceeds from short-term borrowings
                                         75,000,000                                     
          repayment of short-term borrowings
                                                                               
          cash flows from operating activities:
                                                                                
          unrealized loss on equity investment
                                                                                
          payments on acquisition related contingent consideration liability
                                                                               
          (income) income from equity investments
                                   4,200,000                                            
          deferred revenue, deferred rent, and other liabilities
                                    -3,000,000                                            
          unrealized income on equity investment
                                     4,800,000 9,300,000                                          
          realized income on equity investment
                                                                               
          deferred tax
                                         -1,100,000                                       
          deferred revenue
                                      -3,300,000 3,900,000 -300,000 900,000 300,000 200,000 400,000 -100,000 -200,000 -800,000 800,000 -500,000 600,000 300,000 -300,000 -100,000 200,000 -100,000 -200,000 -1,100,000 181,000 -410,000 -478,000 807,000 135,000 -596,000 -596,000 -595,000 -917,000 394,000 -1,721,000 -1,977,000 -957,000 -1,355,000 -1,564,000 -399,000 11,641,000 -42,000 -42,000 463,000  
          deferred rent and other liabilities
                                      -700,000 900,000 400,000 400,000 300,000 1,200,000 2,700,000 1,300,000 700,000 200,000 -400,000 1,900,000 400,000 500,000 -100,000 -100,000 -100,000 -200,000   501,000 -88,000 -32,000 119,000 -22,000 -33,000 -9,000 -15,000 70,000 222,000 -41,000 -49,000 2,000 -42,000 -36,000 27,000 210,000 6,000 7,000  
          reconciliation of cash, cash equivalents and restricted cash:
                                                                                
          purchase of available-for-sale marketable securities
                                       -192,100,000 -32,000,000 -50,500,000 -84,000,000 -7,400,000 -9,100,000 -9,200,000 -10,100,000 -10,800,000 -9,800,000 -7,900,000 -4,900,000 -22,600,000 -3,900,000 -3,400,000 -3,000,000 -3,900,000 -3,500,000 -4,000,000 -4,900,000 -10,118,000 -13,999,000 -15,665,000 -26,618,000 -24,611,000 -28,614,000 -45,439,000 -3,991,000 -29,759,000 -4,033,000 -7,390,000 -32,265,000 -11,673,000 -5,192,000 -3,044,000 -45,361,000 -4,036,000 -8,000 -15,378,000 -17,564,000  
          proceeds from the maturity of available-for-sale marketable securities
                                       42,500,000 32,900,000 27,400,000 10,700,000 8,900,000 9,500,000 7,500,000 10,600,000 11,100,000 8,700,000 9,600,000 4,500,000 4,700,000 3,800,000 3,400,000 2,600,000 6,700,000 7,400,000 12,100,000 18,900,000 18,075,000 20,387,000 25,269,000 40,569,000 24,710,000 19,518,000 7,500,000 12,558,000 11,650,000 13,453,000 12,386,000 17,202,000 18,373,000 18,200,000 10,283,000 7,000,000 10,501,000 12,099,000 8,992,000 32,210,000 31,540,000 
          reconciliation of cash and restricted cash:
                                                                                
          cash
                                       -120,200,000 420,400,000                                        
          total cash and restricted cash
                                       -120,200,000 420,700,000                                        
          other non-cash expenses
                                         -2,900,000 5,700,000 400,000           100,000                          
          repayment of long-term debt
                                            -1,700,000 -600,000 -600,000 -500,000 -600,000 -600,000 -500,000 -600,000 -500,000                          
          effect of exchange rate changes on cash and cash equivalents
                                         2,300,000 -1,000,000 -200,000  -100,000                 -21,000 -1,000 19,000 -7,000 -34,000 -7,000 -43,000 10,000 -8,000 -5,000 5,000 -26,000 17,000      
          increase in cash and cash equivalents
                                         6,200,000 242,400,000 59,000,000 -3,200,000 10,200,000   800,000 17,600,000 13,500,000 -17,600,000 13,700,000 3,800,000 2,500,000 9,800,000 5,200,000 9,300,000 10,800,000 3,309,000 -1,241,000 866,000 2,566,000 -14,970,000 -16,366,000 30,084,000 -1,084,000 -640,000 -561,000 -4,610,000 7,123,000    -3,424,000 8,058,000 -321,000 -18,989,000 837,000  
          cash and cash equivalents, beginning of period
                                         94,500,000 86,100,000 71,800,000 43,200,000 8,100,000  2,553,000  4,889,000  3,577,000  12,700,000  23,115,000  
          cash and cash equivalents, end of period
                                         6,200,000 242,400,000 153,500,000  10,200,000 9,600,000 77,900,000  17,600,000 13,500,000 54,200,000             -16,366,000                
          issuance of common stock in connection with acquisition
                                                                              
          acquisition-related holdback liability
                                                                              
          assets acquired and financing obligation under build-to-suit leasing arrangement
                                                                              
          non-cash research and development charge through issuance of common stock
                                                                               
          impairment of intangible assets
                                                                                
          cash and cash equivalents, ending of period
                                                     3,800,000 45,700,000 9,800,000 5,200,000 9,300,000 18,900,000  -1,241,000 866,000 5,119,000    3,805,000  -561,000 -4,610,000 10,700,000  2,154,000 -5,068,000 9,276,000  -321,000 -18,989,000 23,952,000  
          supplemental disclosure of cash flow information
                                                                                
          cash paid during the year for interest
                                                                                
          cash paid during the year for taxes
                                                                                
          issuance of common stock in connection with contingent consideration settlement
                                                                                
          accretion and amortization related to marketable securities
                                             100,000 100,000 100,000 100,000 100,000   100,000                        
          amortization of debt issuance costs
                                                100,000 100,000 100,000 100,000 100,000 100,000 100,000           6,000 24,000 6,000 68,000 -19,000 145,000 52,000 134,000 138,000 135,000 139,000 139,000 
          loss on disposal of equipment
                                                 100,000 200,000                             
          decrease in cash and cash equivalents
                                               -8,200,000                         2,154,000        
          change in fair value of contingent consideration
                                                    -900,000 -1,000,000 1,200,000 500,000 1,000,000 700,000 300,000 -240,000 278,000                    
          adjustments to reconcile net income to cash from in operating activities:
                                                                                
          release of valuation allowance against deferred tax assets
                                                           16,000 -1,316,000                  
          net proceeds from issuance of long-term debt
                                                                                
          repayment of equipment loan
                                                               -75,000 -225,000 -225,000 -225,000 -225,000 -225,000 -225,000 -225,000 -569,000 -569,000 -568,000 -912,000 -569,000 -226,000 -343,000  
          supplemental disclosure of non-cash transactions
                                                                                
          issuance of common stock in connection with acquisition and contingent consideration
                                                            6,063,000                  
          accretion and amortization related to investments
                                                          100,000 136,000 166,000 213,000 285,000 299,000 294,000 170,000 146,000 149,000 191,000 227,000 154,000 128,000 238,000 334,000 191,000 27,000 21,000 -10,000 -37,000  
          accretion of non-cash interest expense related to convertible notes
                                                                                
          loss on debt extinguishment upon conversion of convertible debt
                                                                   3,000 312,000 245,000 7,930,000          
          cash and cash equivalents, beginning of year
                                                                                
          cash and cash equivalents, ending of year
                                                                                
          supplemental disclosure of cash flow information:
                                                                                
          non-cash investing and financing transactions:
                                                                                
          conversion of convertible notes to common stock
                                                                   -763,000 4,001,000 1,549,000 41,483,000          
          other non-cash
                                                             -60,000 61,000                  
          non-cash restructuring charge
                                                                                
          proceeds from the sale of equipment
                                                                                
          unrealized gain on marketable securities
                                                                                
          accretion related to convertible debt discount
                                                                    51,000 89,000 919,000  1,241,000 1,186,000 1,135,000      
          compensation expense associated with stock options issued to consultants
                                                                                
          proceeds from equipment loan
                                                                           343,000 -343,000 3,000,000 
          non-cash restructuring benefit
                                                                        -362,000      
          proceeds from issuance of senior convertible notes
                                                                               
          payment of senior convertible notes issuance costs
                                                                                
          purchase of senior convertible notes call spread options
                                                                                
          net cash provided by/(used in) investing activities
                                                                        12,183,000 6,485,000 -39,311,000  11,482,000    
          common shares received as settlement for a call spread option
                                                                            869,000  
          stock-based compensation
                                                                                
          net cash provided/(used) in investing activities
                                                                              13,586,000  
          conversion of series a, b, c, and d preferred stock
                                                                                
          accretion to redemption value of series b, series c, and series d redeemable convertible preferred stock
                                                                                
          other assets
                                                                                
          other liabilities
                                                                                
          non-cash investing and financing activities
                                                                                
          deferred rent
                                                                                
          net proceeds from issuance of preferred stock
                                                                                
          interest on converted notes
                                                                                
          prepaid and other current assets
                                                                                
          proceeds on sale of equipment
                                                                                
          proceeds from convertible notes payable
                                                                                
          purchase of technology in exchange for common stock
                                                                                
          conversion of notes payable into series b preferred stock
                                                                                
          unrealized loss on marketable securities