7Baggers
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-09-30 2019-06-30 2019-03-31 2018-09-30 2018-06-30 2018-03-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 
      
    		                                                                    
      operating activities
    		                                                                    
      net income
    		283,800,000 179,800,000 105,400,000 151,700,000 134,600,000 143,500,000 146,400,000 256,300,000 120,700,000 115,900,000 48,600,000 91,800,000 101,200,000 50,900,000 97,300,000 -19,400,000 70,900,000 62,900,000 40,300,000 355,200,000 72,200,000 46,300,000 19,900,000 45,800,000 -10,500,000 -26,900,000 46,600,000 30,200,000 -24,200,000 -2,000,000 2,900,000 -41,700,000 -7,400,000 -18,800,000 -20,200,000 -19,200,000 1,500,000 -42,500,000 -3,700,000 -12,900,000 -5,200,000 -6,000,000 -12,500,000 -2,600,000 -6,000,000 -10,100,000 -11,100,000 -8,482,000 -17,263,000 -14,691,000 -14,064,000 -12,251,000 -13,278,000 -7,367,000 -11,850,000 -9,812,000 -13,398,000 -11,687,000 -20,273,000 -11,529,000 -13,523,000 -15,330,000 -13,142,000 -13,450,000 -14,688,000 -14,074,000 -12,972,000 -12,229,000 
      adjustments to reconcile net income to cash from operating activities:
    		                                                                    
      depreciation and amortization
    		63,600,000 63,000,000 60,000,000 57,800,000 55,300,000 52,100,000 52,500,000 52,500,000 48,200,000 43,700,000 41,600,000 36,300,000 39,200,000 43,600,000 36,800,000 32,100,000 25,500,000 23,500,000 20,900,000 20,400,000 18,400,000 15,300,000 13,000,000 12,900,000 11,600,000 9,900,000 7,800,000 6,700,000 6,000,000 4,300,000 3,900,000 3,700,000 3,600,000 4,100,000 3,900,000 3,400,000 3,100,000 2,700,000 2,600,000 2,400,000 2,200,000 1,900,000 1,900,000 1,900,000 1,700,000 1,600,000 1,800,000 1,751,000 2,199,000 1,468,000 1,182,000 1,063,000 998,000 892,000 806,000 721,000 628,000 588,000 500,000 470,000 589,000 662,000 652,000 768,000 710,000 703,000 855,000 1,004,000 
      share-based compensation
    		45,100,000 45,300,000 34,200,000 43,300,000 43,400,000 44,700,000 39,000,000 36,900,000 39,000,000 39,700,000 35,200,000 34,000,000 30,800,000 32,600,000 29,100,000 26,300,000 27,500,000 31,600,000 28,000,000 34,100,000 30,700,000 30,700,000 23,900,000 24,400,000 29,700,000 25,000,000 27,100,000 25,600,000 24,600,000 25,400,000 25,300,000 30,600,000 29,100,000 29,000,000 27,600,000 25,100,000 23,500,000 22,600,000 20,700,000 15,900,000 13,800,000 13,200,000 8,700,000 6,600,000 6,600,000 6,400,000 5,000,000 4,542,000 4,879,000 4,833,000 4,146,000 3,580,000 3,728,000 3,657,000 2,548,000 2,078,000 2,317,000 2,771,000 2,275,000 2,154,000 2,130,000 2,041,000 2,041,000  1,787,000 1,972,000 1,948,000  
      non-cash interest expense
    		1,900,000 1,800,000 1,900,000 1,900,000 1,900,000 1,800,000 1,900,000 2,000,000 2,200,000 2,100,000 1,500,000 1,600,000 1,500,000 1,600,000 1,600,000 22,000,000 22,000,000 22,500,000 22,200,000 22,000,000 21,700,000 17,600,000 12,700,000 12,500,000 12,300,000 12,200,000 3,800,000 3,800,000 3,700,000 3,600,000                                       
      deferred income taxes
    		118,000,000 -8,900,000 -5,800,000 24,300,000 -11,600,000 -14,700,000 -41,800,000 81,500,000 -85,000,000 -42,200,000 -9,300,000 32,000,000 -33,800,000 -19,900,000 100,000 -5,100,000 100,000 400,000 -300,000                                                  
      net (gains) losses on equity investments
    		                                                                    
      other non-cash income and expenses
    		-6,000,000 -400,000 -12,300,000 16,000,000 -39,900,000 -15,600,000 -7,800,000 -36,600,000 -17,900,000 -15,700,000 -13,700,000 2,800,000 15,900,000 12,200,000 3,800,000 13,100,000 14,500,000 8,000,000 8,000,000 9,600,000 600,000 3,400,000 100,000 2,500,000 -2,200,000 300,000 300,000 5,600,000 -900,000                                        
      changes in operating assets and liabilities:
    		                                                                    
      accounts receivable
    		237,800,000 -184,600,000 -148,900,000 -7,400,000 -55,600,000 33,800,000 -5,800,000 -187,200,000 -35,800,000 -113,700,000 76,600,000 -148,300,000 -4,500,000 -17,000,000 -30,100,000 15,100,000 -35,700,000 -40,000,000 -14,900,000 -58,500,000 -73,400,000 4,300,000 -14,700,000 -18,400,000 -12,300,000 21,500,000 -8,100,000 -38,800,000 10,700,000 -8,700,000 -15,300,000 15,800,000 -25,000,000 -3,000,000 -6,000,000 6,800,000 -18,300,000 -10,300,000 -5,300,000 2,200,000 -2,800,000 -4,700,000 2,200,000 -4,500,000 -3,800,000 -1,400,000 3,200,000 -7,190,000 543,000 -357,000 4,000 -3,544,000 -309,000 -1,536,000 -487,000 -1,569,000 -441,000 -860,000 -311,000 -1,003,000 -420,000 -722,000 -227,000 -689,000 139,000 -247,000 -106,000  
      inventory
    		-33,600,000 -18,500,000 6,200,000 32,700,000 -1,900,000 18,300,000 -36,700,000 -59,000,000 -78,600,000 -55,400,000 -59,600,000 5,700,000 26,900,000 1,100,000 15,600,000 -6,000,000 -21,700,000 -29,500,000 -55,000,000 -33,600,000 -35,400,000 -23,300,000 -22,200,000 -2,500,000 -16,800,000 -30,400,000 -9,000,000 5,400,000 -6,400,000 -600,000 3,800,000 -1,000,000 -900,000 -1,700,000 3,700,000 -10,900,000 -4,600,000 -8,200,000 -4,000,000 -2,400,000 -2,700,000 -2,800,000 200,000 900,000 -2,700,000 300,000 -100,000 -330,000 237,000 666,000 127,000 -1,716,000 -197,000 167,000 1,687,000 -1,759,000 -2,266,000 -236,000 -1,210,000 -709,000 -569,000 1,002,000 81,000 144,000 181,000 -947,000 -685,000 -104,000 
      prepaid and other assets
    		-2,400,000 -22,000,000 16,500,000 8,000,000 31,600,000 -56,800,000 11,400,000 6,100,000 16,600,000 10,000,000 -13,400,000 -50,400,000 1,300,000 15,400,000 -97,900,000 -3,100,000 8,900,000 -6,900,000 -20,200,000 9,400,000 14,800,000 -19,000,000 -7,600,000 800,000 2,000,000 -5,400,000 1,600,000 -2,300,000 -2,700,000 2,500,000 1,500,000 -7,700,000 200,000 -1,400,000 -1,700,000 -1,000,000   -1,200,000 200,000 1,300,000   -900,000 300,000 -700,000 -100,000 -18,000 -139,000 -412,000 -231,000 720,000 689,000 -560,000 389,000 -1,133,000 162,000 -136,000 2,395,000 -1,539,000 696,000 -563,000 402,000 -133,000 337,000 -478,000 422,000 -36,000 
      operating lease right-of-use assets and liabilities
    		-1,500,000 -2,100,000 -900,000 -3,500,000 600,000 -1,600,000 -2,000,000 -100,000 -2,300,000 -1,400,000 -700,000 300,000 -2,700,000 -2,500,000 -900,000 0 -1,200,000 400,000 700,000 500,000 -100,000 -800,000 -400,000                                              
      accounts payable and accrued liabilities
    		-2,300,000 234,000,000 125,400,000 -20,000,000 49,800,000 72,300,000 109,600,000 -30,000,000 219,500,000 190,300,000 86,700,000 123,800,000 75,300,000 42,500,000 53,500,000 -57,300,000   30,000,000 67,900,000 69,800,000 51,500,000 5,300,000 24,300,000 28,400,000 25,500,000 17,300,000 30,700,000 2,200,000 10,700,000 -300,000 2,100,000 2,500,000 9,300,000 5,600,000 3,700,000 5,000,000 9,100,000 2,100,000 1,600,000 1,700,000 4,500,000 -100,000 -500,000 2,100,000 1,300,000 -500,000 -2,066,000 2,817,000 180,000 -631,000 301,000 1,080,000 731,000 -1,116,000 -1,728,000 1,387,000 572,000 -663,000 1,372,000 255,000 344,000 -463,000 1,581,000 -1,060,000 491,000 -1,303,000  
      accrued payroll and related expenses
    		41,300,000 15,900,000 -600,000 4,300,000 -9,100,000 5,500,000 -60,700,000 20,600,000 42,100,000 13,800,000 -39,300,000 22,500,000 17,100,000 9,400,000 -40,500,000 9,900,000 16,700,000 16,800,000 -33,000,000 21,800,000 25,100,000 8,300,000 -29,100,000 -2,800,000 22,700,000 -21,100,000 8,200,000 12,400,000 -14,400,000 3,700,000 1,200,000 -3,300,000 6,500,000 3,700,000 6,500,000 -8,200,000 4,600,000 3,300,000 4,900,000 -5,100,000 3,700,000 2,000,000 -4,000,000 2,700,000 2,300,000 2,800,000 -2,000,000 542,000 732,000 1,679,000 -553,000 -157,000 558,000 1,700,000 -1,027,000 107,000 740,000 835,000 -358,000 846,000 402,000 971,000 72,000 -607,000 291,000 21,000 -127,000 -107,000 
      deferred revenue and other liabilities
    		-7,700,000 -300,000 2,700,000 -7,700,000 400,000 -3,900,000 3,200,000 -8,500,000 1,500,000 3,200,000 1,200,000 -19,600,000 25,000,000 2,900,000 2,800,000 2,000,000 3,700,000 1,900,000 1,100,000 1,900,000 1,300,000 14,400,000 1,000,000 -5,000,000                                             
      net cash from operating activities
    		659,900,000 303,000,000 183,800,000 301,400,000 199,500,000 279,400,000 209,200,000 133,600,000 269,200,000 190,300,000 155,400,000 132,500,000 293,200,000 172,800,000 71,000,000 105,800,000 247,300,000 61,600,000 27,800,000 172,000,000 147,600,000 154,100,000 1,900,000 94,500,000 64,500,000 11,800,000 56,800,000 41,400,000 -8,700,000 36,200,000 14,300,000 300,000 13,300,000 23,000,000 20,100,000 -200,000 11,300,000 17,900,000 16,400,000 3,400,000 11,400,000 6,200,000 -2,400,000 4,400,000 1,600,000 900,000 -4,500,000 -10,557,000 -6,050,000 -6,329,000 -10,164,000 -11,570,000 -6,741,000 -2,526,000 -9,289,000 -13,464,000 -9,470,000 -9,305,000 -10,437,000 -9,173,000 -9,808,000 -11,036,000 -9,372,000 2,526,000 -11,617,000 -11,901,000 -16,459,000  
      capex
    		-85,800,000 -100,000,000 -29,400,000 -124,600,000 -124,300,000 -16,100,000 -16,200,000 -52,500,000 -56,800,000 -61,400,000 -18,900,000 -63,500,000 -108,200,000 -91,500,000 -75,000,000 -80,200,000 -121,100,000 -93,000,000 -64,700,000 -60,200,000 -36,600,000 -60,800,000 -13,600,000 15,200,000 -49,900,000 -29,200,000 -27,100,000 -8,300,000 -11,000,000 -11,900,000 -12,700,000 -17,300,000 -17,600,000 -16,100,000 -10,500,000 -11,500,000 -11,600,000 -7,400,000 -6,300,000 -8,000,000 -3,700,000 -4,000,000 -3,900,000 -2,300,000 -2,200,000 -2,000,000 -1,400,000 -1,404,000 -2,894,000 -2,882,000 -2,320,000 -3,549,000 -1,506,000 -1,160,000 -1,791,000 -2,326,000 -2,093,000 -1,483,000 -958,000 -463,000 -825,000 -754,000 -950,000 -431,000 -609,000 -392,000 -1,060,000  
      free cash flows
    		574,100,000 203,000,000 154,400,000 176,800,000 75,200,000 263,300,000 193,000,000 81,100,000 212,400,000 128,900,000 136,500,000 69,000,000 185,000,000 81,300,000 -4,000,000 25,600,000 126,200,000 -31,400,000 -36,900,000 111,800,000 111,000,000 93,300,000 -11,700,000 109,700,000 14,600,000 -17,400,000 29,700,000 33,100,000 -19,700,000 24,300,000 1,600,000 -17,000,000 -4,300,000 6,900,000 9,600,000 -11,700,000 -300,000 10,500,000 10,100,000 -4,600,000 7,700,000 2,200,000 -6,300,000 2,100,000 -600,000 -1,100,000 -5,900,000 -11,961,000 -8,944,000 -9,211,000 -12,484,000 -15,119,000 -8,247,000 -3,686,000 -11,080,000 -15,790,000 -11,563,000 -10,788,000 -11,395,000 -9,636,000 -10,633,000 -11,790,000 -10,322,000 2,095,000 -12,226,000 -12,293,000 -17,519,000  
      investing activities
    		                                                                    
      purchases of marketable securities
    		-175,900,000 -608,200,000 -462,500,000  -306,900,000 -784,200,000 -992,400,000  -798,000,000 -1,340,300,000 -809,600,000  -254,000,000 -597,200,000 -546,500,000  -368,300,000 -369,900,000 -802,000,000  -403,100,000 -1,374,200,000 -365,800,000                                              
      proceeds from sale and maturity of marketable securities
    		466,200,000 638,700,000 650,200,000 405,200,000 630,600,000 666,800,000 1,121,800,000 719,000,000 671,400,000 859,400,000 697,600,000 740,000,000 602,200,000 543,800,000 241,800,000 501,000,000 537,000,000 838,300,000 790,000,000 952,000,000 449,000,000 319,500,000 530,000,000 259,200,000 291,300,000 222,500,000                                           
      purchases of property and equipment
    		-80,500,000 -94,100,000 -87,000,000 -124,600,000 -111,200,000 -66,100,000 -56,900,000 -52,500,000 -50,400,000 -59,000,000 -74,700,000 -63,500,000 -108,200,000 -91,500,000 -101,600,000 -80,200,000 -108,100,000 -101,200,000 -99,700,000 -60,200,000 -47,400,000 -58,200,000 -33,200,000                                              
      purchases of non-marketable equity securities
    		                                                                    
      other investing activities
    		1,000,000 0 -500,000 -10,200,000 -2,200,000 -5,400,000 2,300,000 900,000 -2,500,000   -2,000,000 -10,000,000 0 -2,300,000 14,600,000 0 -4,000,000 -500,000 -700,000 -7,800,000 -2,400,000 -400,000                                              
      net cash from investing activities
    		192,800,000 -63,600,000 100,200,000 -303,700,000 210,300,000 -188,900,000 74,800,000 414,900,000 -179,500,000 -555,900,000 -186,700,000 -194,100,000 229,300,000 -144,900,000 -411,800,000 -496,100,000 29,000,000 363,200,000 -112,200,000 -24,000,000 -9,300,000 -1,115,300,000 130,600,000 -412,800,000 -639,400,000 131,300,000 4,600,000 -159,900,000 -15,400,000 -36,600,000 -85,300,000 -21,400,000 -17,300,000 -17,800,000 -9,600,000 -11,200,000 -12,700,000 -5,700,000 -7,200,000 -25,900,000 -3,800,000 -4,000,000 -4,300,000 500,000 1,700,000 6,100,000 12,600,000 6,553,000 3,494,000 6,722,000 11,631,000 -3,446,000 -10,602,000 -39,099,000 6,776,000 -20,429,000 7,327,000 3,513,000 -16,021,000          
      financing activities
    		                                                                    
      net proceeds from issuance of common stock
    		13,900,000 0 14,200,000 0 14,800,000 0 13,400,000 0 14,300,000 0 12,300,000 0 12,400,000 0 10,100,000 0 11,600,000 0 8,700,000 0 8,600,000 0 6,700,000 6,800,000 100,000 5,000,000 5,400,000 1,000,000 4,200,000 4,300,000 400,000 5,300,000 500,000 5,100,000 1,000,000 3,800,000 2,800,000 5,900,000 4,900,000 5,500,000 6,600,000 2,200,000 9,700,000 5,100,000 1,900,000 2,300,000 2,700,000 694,000 1,334,000 452,000 1,120,000 47,000 1,033,000 71,941,000 1,688,000 33,485,000 1,850,000 1,397,000 33,814,000 79,000 343,000 78,000 45,810,000 66,000 384,000 259,000 1,053,000 207,000 
      purchases of treasury stock
    		   0    -500,000,000 0   0                                                         
      other financing activities
    		-1,700,000 -1,700,000 -1,700,000 -1,600,000 -1,300,000 -1,400,000 -8,700,000 4,900,000 -1,200,000 -1,100,000 -1,100,000 -1,000,000 -7,200,000 -4,300,000 -4,800,000 -800,000 -800,000 -400,000 -7,900,000 -4,900,000 -4,100,000 -200,000 -200,000 -100,000 -200,000 -100,000                                           
      net cash from financing activities
    		-175,000,000 -1,700,000 12,500,000 -1,600,000 -736,500,000 -1,400,000 4,700,000 -631,900,000 -637,400,000 939,500,000 11,200,000 -1,000,000 -552,500,000 -4,300,000 5,300,000 -800,000 10,800,000 -400,000 800,000 -4,900,000 4,500,000 906,000,000 6,500,000 6,000,000 -100,000 4,900,000 5,400,000 -800,000 4,200,000 4,300,000 314,400,000 80,300,000 500,000 5,100,000 -700,000 3,200,000 2,200,000 5,400,000 4,300,000 4,900,000 6,100,000 1,600,000 9,200,000 4,900,000 1,900,000 2,300,000 2,700,000 7,294,000 1,334,000 452,000 1,120,000 47,000 958,000 71,716,000 1,463,000 33,260,000 1,625,000 1,172,000 33,589,000 -146,000 -226,000 -491,000 45,242,000 -503,000 -185,000 -310,000 3,710,000 -204,000 
      effect of exchange rate changes on cash, cash equivalents and restricted cash
    		-1,100,000 16,500,000 2,300,000 -11,200,000 8,600,000 -1,000,000 -3,800,000 6,100,000 -3,500,000 -2,200,000 1,100,000 6,800,000 -7,300,000 -4,300,000 -1,000,000 -500,000 -1,000,000 500,000 -400,000 1,300,000 1,000,000 300,000 -500,000 -1,400,000 -900,000 600,000 400,000 -900,000 -900,000                                        
      increase in cash, cash equivalents and restricted cash
    		676,600,000 254,200,000 298,800,000 -15,100,000 -318,100,000 88,100,000 284,900,000 -77,300,000 -551,200,000   -55,800,000 -37,300,000   -391,600,000 286,100,000 424,900,000 -84,000,000 144,400,000 143,800,000 -54,900,000 138,500,000   148,600,000 67,200,000 -120,200,000 -20,800,000                                        
      cash, cash equivalents and restricted cash, beginning of period
    		0 0 607,300,000 0 0 0 567,500,000 0 0 0 643,300,000 0 0 0 1,053,600,000 0 0 0 818,200,000 0 0 0 446,400,000 0 0 1,137,100,000 0 0 441,500,000                                        
      cash, cash equivalents and restricted cash, end of period
    		676,600,000 254,200,000 906,100,000 -15,100,000 -318,100,000 88,100,000 852,400,000 -77,300,000 -551,200,000 571,700,000 624,300,000 -55,800,000 -37,300,000 19,300,000 717,100,000 -391,600,000 286,100,000 424,900,000 734,200,000 144,400,000 143,800,000 -54,900,000 584,900,000 -313,700,000 -575,900,000 1,285,700,000 67,200,000 -120,200,000 420,700,000                                        
      reconciliation of cash, cash equivalents and restricted cash, end of period:
    		                                                                    
      cash and cash equivalents
    		676,700,000 254,100,000 904,900,000 -15,100,000 -318,000,000 88,000,000 851,200,000 -77,400,000 -551,200,000 571,700,000 623,200,000 -55,800,000 -37,300,000 19,400,000 716,000,000 -391,700,000 285,500,000 425,000,000 733,800,000 144,100,000 143,500,000 -54,600,000 584,600,000 -313,600,000 -575,900,000 1,285,100,000                                           
      restricted cash
    		-100,000 100,000 1,200,000 0 -100,000 100,000 1,200,000 100,000 0 0 1,100,000 0 0 -100,000 1,100,000 100,000 600,000 -100,000 400,000 300,000   300,000 -100,000 0 600,000 0 0 300,000        0 700,000          0 0 0 -100,000 0 325,000 225,000 225,000 225,000 225,000 25,000 225,000 225,000 569,000 494,000 568,000 569,000 569,000 569,000 -5,063,000  
      total cash, cash equivalents and restricted cash
    		676,600,000 254,200,000 906,100,000 -15,100,000 -318,100,000 88,100,000 852,400,000 -77,300,000 -551,200,000 571,700,000 624,300,000 -55,800,000 -37,300,000 19,300,000 717,100,000 -391,600,000 286,100,000 424,900,000 734,200,000 144,400,000 143,800,000 -54,900,000 584,900,000 -313,700,000 -575,900,000 1,285,700,000                                           
      supplemental disclosure of non-cash investing and financing transactions:
    		                                                                    
      acquisition of property and equipment included in accounts payable and accrued liabilities
    		-5,300,000 -5,900,000 57,600,000  -13,100,000 50,000,000 40,700,000  -6,400,000 -2,400,000 55,800,000    26,600,000  -13,000,000 8,200,000 35,000,000  10,800,000 -2,600,000 19,600,000 15,200,000 -3,000,000 10,100,000 -3,300,000 2,000,000 4,300,000 1,600,000 -700,000 5,600,000                                     
      right-of-use assets obtained in exchange for operating lease liabilities
    		2,200,000    -500,000 7,600,000 1,100,000  1,900,000 2,200,000 1,900,000    -1,300,000  1,800,000 500,000 9,900,000                                                  
      right-of-use assets obtained in exchange for finance lease liabilities
    		0 300,000 1,100,000  2,000,000 2,400,000 7,400,000  300,000 500,000 1,000,000    5,200,000  1,700,000                                                    
      purchase of marketable securities
    		                        -883,800,000 -50,700,000                                           
      acquisitions, net of cash acquired
    		           0 -700,000 0 -3,200,000 1,400,000                 -100,000 0   0 0                               
      proceeds from issuance of convertible notes, net of issuance costs
    		                   0 0                                                
      purchases of capped call transactions
    		       0 0                                                            
      payments for conversions of senior convertible notes
    		       -136,800,000                                                             
      proceeds from issuance of senior convertible notes, net of issuance costs
    		        0                                                            
      shares issued for conversions of 2023 notes
    		              35,900,000                                                      
      shares received under note hedge upon conversion of 2023 notes
    		                                                                    
      collaborative research and development fee
    		                                                                    
      loss on extinguishment of debt
    		               700,000    0 500,000                                                
      realized (gain) loss on equity investment
    		       -900,000    0 0 0 -200,000                                                      
      decrease in cash, cash equivalents and restricted cash
    		          -19,000,000    -336,500,000         -313,700,000                                             
      repurchase of convertible notes
    		                   0 0                                                
      shares received under note hedge upon conversions of 2023 notes
    		              -33,500,000                                                      
      * we adjusted our 2021 amounts to reflect the simplified convertible instruments accounting guidance, which we adopted on a full retrospective basis. refer to note 1 “organization and significant accounting policies” for further information.
    		                                                                    
      shares issued for repurchase and conversions of senior convertible notes
    		                                                                    
      common stock issued for repurchase and conversions of senior convertible notes
    		                    160,900,000                                                
      non-cash collaborative research and development fee through issuance of common stock
    		                                                                    
      unrealized gain on equity investment
    		                            -7,400,000                                        
      proceeds from sale of warrants
    		                                                                    
      purchase of convertible note hedge
    		                                                                    
      realized loss on equity investment
    		                                                                    
      cash flows from investing activities:
    		                                                                    
      cash flows from financing activities:
    		                                                                    
      right-of-use assets obtained in exchange for lease liabilities
    		                     0 5,300,000 1,400,000 10,600,000 45,200,000                                           
      purchases of other equity investments
    		                                                                    
      cash flows from operating activities:
    		                                                                    
      unrealized (gain) loss on equity investment
    		                                                                    
      payments on acquisition related contingent consideration liability
    		                          0                                          
      (income) income from equity investments
    		                        0 4,200,000                                           
      purchase of other equity investments
    		                        0 -1,200,000 0 0 -1,000,000                                        
      purchase of property and equipment
    		                        -46,900,000 -39,300,000 -23,800,000 -10,300,000 -15,300,000 -13,500,000 -12,000,000 -22,900,000 -17,600,000 -16,100,000 -10,500,000 -11,500,000 -11,600,000 -7,400,000 -6,300,000 -8,000,000 -3,700,000 -4,000,000 -3,900,000 -2,300,000 -2,200,000 -2,000,000 -1,400,000 -1,404,000 -2,894,000 -2,882,000 -2,320,000 -3,549,000 -1,506,000 -1,160,000 -1,791,000 -2,326,000 -2,093,000 -1,483,000 -958,000 -463,000 -825,000 -754,000 -950,000 -431,000 -609,000 -392,000 -1,060,000  
      deferred revenue, deferred rent, and other liabilities
    		                         -3,000,000                                           
      unrealized income on equity investment
    		                          9,300,000                                          
      realized income on equity investment
    		                                                                    
      deferred tax
    		                             -1,100,000                                       
      deferred revenue
    		                          -3,300,000 3,900,000 -300,000 900,000 300,000 200,000 400,000 -100,000 0 -200,000 -800,000 800,000 -500,000 600,000 300,000 -300,000 -100,000 200,000 -100,000 -200,000 -1,100,000 181,000 -410,000 -478,000 807,000 135,000 -596,000 -596,000 -595,000 -917,000 394,000 -1,721,000 -1,977,000 -957,000 -1,355,000 -1,564,000 -399,000 11,641,000 -42,000 -42,000 463,000  
      deferred rent and other liabilities
    		                          -700,000 900,000 400,000 400,000 300,000 1,200,000 2,700,000 1,300,000 700,000 200,000 -400,000 1,900,000 400,000 500,000 -100,000 -100,000 -100,000 -200,000 0   501,000 -88,000 -32,000 119,000 -22,000 -33,000 -9,000 -15,000 70,000 222,000 -41,000 -49,000 2,000 -42,000 -36,000 27,000 210,000 0 6,000 7,000  
      proceeds from issuance of convertible debt, net of issuance costs
    		                             0                                       
      proceeds from short-term borrowings
    		                             0 0 75,000,000                                     
      repayment of short-term borrowings
    		                             0                                       
      reconciliation of cash, cash equivalents and restricted cash:
    		                                                                    
      purchase of available-for-sale marketable securities
    		                           -192,100,000 -32,000,000 -50,500,000 -84,000,000 -7,400,000 -9,100,000 -9,200,000 -10,100,000 -10,800,000 -9,800,000 -7,900,000 -4,900,000 -22,600,000 -3,900,000 -3,400,000 -3,000,000 -3,900,000 -3,500,000 -4,000,000 -4,900,000 -10,118,000 -13,999,000 -15,665,000 -26,618,000 -24,611,000 -28,614,000 -45,439,000 -3,991,000 -29,759,000 -4,033,000 -7,390,000 -32,265,000 -11,673,000 -5,192,000 -3,044,000 -45,361,000 -4,036,000 -8,000 -15,378,000 -17,564,000  
      proceeds from the maturity of available-for-sale marketable securities
    		                           42,500,000 32,900,000 27,400,000 10,700,000 8,900,000 9,500,000 7,500,000 10,600,000 11,100,000 8,700,000 9,600,000 4,500,000 4,700,000 3,800,000 3,400,000 2,600,000 6,700,000 7,400,000 12,100,000 18,900,000 18,075,000 20,387,000 25,269,000 40,569,000 24,710,000 19,518,000 7,500,000 12,558,000 11,650,000 13,453,000 12,386,000 17,202,000 18,373,000 18,200,000 10,283,000 7,000,000 10,501,000 12,099,000 8,992,000 32,210,000 31,540,000 
      reconciliation of cash and restricted cash:
    		                                                                    
      cash
    		                           -120,200,000 420,400,000                                        
      total cash and restricted cash
    		                           -120,200,000 420,700,000                                        
      other non-cash expenses
    		                             -2,900,000 5,700,000 400,000           100,000                          
      repayment of long-term debt
    		                                0 0 -1,700,000 -600,000 -600,000 -500,000 -600,000 -600,000 -500,000 -600,000 -500,000                          
      effect of exchange rate changes on cash and cash equivalents
    		                             2,300,000 -1,000,000 -200,000  -100,000              19,000 -19,000 21,000 -21,000 -1,000 19,000 -7,000 -34,000 -7,000 -43,000 10,000 -8,000 -5,000 5,000 -26,000 17,000      
      increase in cash and cash equivalents
    		                             6,200,000 242,400,000 59,000,000 -3,200,000 10,200,000   800,000 17,600,000 13,500,000 -17,600,000 13,700,000 3,800,000 2,500,000 9,800,000 5,200,000 9,300,000 10,800,000 3,309,000 -1,241,000 866,000 2,566,000 -14,970,000 -16,366,000 30,084,000 -1,084,000 -640,000 -561,000 -4,610,000 7,123,000    -3,424,000 8,058,000 -321,000 -18,989,000 837,000  
      cash and cash equivalents, beginning of period
    		                             0 0 94,500,000 0 0 0 86,100,000 0 0 0 71,800,000 0 0 43,200,000 0 0 0 8,100,000  0 0 2,553,000  0 0 4,889,000  0 0 3,577,000  0 0 12,700,000  0 0 23,115,000  
      cash and cash equivalents, end of period
    		                             6,200,000 242,400,000 153,500,000  10,200,000 9,600,000 77,900,000  17,600,000 13,500,000 54,200,000             -16,366,000                
      issuance of common stock in connection with acquisition
    		                                0 0                                   
      acquisition-related holdback liability
    		                                0 0                                   
      assets acquired and financing obligation under build-to-suit leasing arrangement
    		                                0 0                                   
      non-cash research and development charge through issuance of common stock
    		                                    0                                
      impairment of intangible assets
    		                                                                    
      cash and cash equivalents, ending of period
    		                                         3,800,000 45,700,000 9,800,000 5,200,000 9,300,000 18,900,000  -1,241,000 866,000 5,119,000    3,805,000  -561,000 -4,610,000 10,700,000  2,154,000 -5,068,000 9,276,000  -321,000 -18,989,000 23,952,000  
      supplemental disclosure of cash flow information
    		                                                                    
      cash paid during the year for interest
    		                                                                    
      cash paid during the year for taxes
    		                                                                    
      issuance of common stock in connection with contingent consideration settlement
    		                                                                    
      accretion and amortization related to marketable securities
    		                                 100,000 0 100,000 0 100,000 100,000 100,000 0   0 100,000                        
      amortization of debt issuance costs
    		                                    0 100,000 0 100,000 100,000 100,000 100,000 100,000 100,000       0 0   0 6,000 24,000 6,000 68,000 -19,000 145,000 52,000 134,000 138,000 135,000 139,000 139,000 
      loss on disposal of equipment
    		                                     100,000 0 200,000                             
      decrease in cash and cash equivalents
    		                                   -8,200,000                         2,154,000        
      change in fair value of contingent consideration
    		                                        -900,000 -1,000,000 1,200,000 500,000 1,000,000 700,000 300,000 -240,000 278,000                    
      adjustments to reconcile net income to cash from in operating activities:
    		                                                                    
      release of valuation allowance against deferred tax assets
    		                                               16,000 0 0 -1,316,000                  
      net proceeds from issuance of long-term debt
    		                                                                    
      repayment of equipment loan
    		                                               0 0 0 0 0 -75,000 -225,000 -225,000 -225,000 -225,000 -225,000 -225,000 -225,000 -569,000 -569,000 -568,000 -912,000 -569,000 -226,000 -343,000  
      supplemental disclosure of non-cash transactions
    		                                                                    
      issuance of common stock in connection with acquisition and contingent consideration
    		                                                0 0 6,063,000                  
      accretion and amortization related to investments
    		                                              100,000 136,000 166,000 213,000 285,000 299,000 294,000 170,000 146,000 149,000 191,000 227,000 154,000 128,000 238,000 334,000 191,000 27,000 21,000 -10,000 -37,000  
      accretion of non-cash interest expense related to convertible notes
    		                                                   0 0                
      loss on debt extinguishment upon conversion of convertible debt
    		                                                   0 0   3,000 312,000 245,000 7,930,000          
      cash and cash equivalents, beginning of year
    		                                                                    
      cash and cash equivalents, ending of year
    		                                                                    
      supplemental disclosure of cash flow information:
    		                                                                    
      non-cash investing and financing transactions:
    		                                                                    
      conversion of convertible notes to common stock
    		                                                   0 0   -763,000 4,001,000 1,549,000 41,483,000          
      other non-cash
    		                                                 -60,000 61,000                  
      non-cash restructuring charge
    		                                                                    
      proceeds from the sale of equipment
    		                                                                    
      unrealized gain on marketable securities
    		                                                                    
      accretion related to convertible debt discount
    		                                                        51,000 89,000 919,000  1,241,000 1,186,000 1,135,000      
      compensation expense associated with stock options issued to consultants
    		                                                                    
      proceeds from equipment loan
    		                                                               343,000 0 -343,000 3,000,000 0 
      non-cash restructuring benefit
    		                                                            0 0 -362,000      
      proceeds from issuance of senior convertible notes
    		                                                                   0 
      payment of senior convertible notes issuance costs
    		                                                                    
      purchase of senior convertible notes call spread options
    		                                                                    
      net cash provided by/(used in) investing activities
    		                                                            12,183,000 6,485,000 -39,311,000  11,482,000    
      common shares received as settlement for a call spread option
    		                                                                0 0 869,000  
      stock-based compensation
    		                                                                    
      net cash provided/(used) in investing activities
    		                                                                  13,586,000  
      conversion of series a, b, c, and d preferred stock
    		                                                                    
      accretion to redemption value of series b, series c, and series d redeemable convertible preferred stock
    		                                                                    
      other assets
    		                                                                    
      other liabilities
    		                                                                    
      non-cash investing and financing activities
    		                                                                    
      deferred rent
    		                                                                    
      net proceeds from issuance of preferred stock
    		                                                                    
      interest on converted notes
    		                                                                    
      prepaid and other current assets
    		                                                                    
      proceeds on sale of equipment
    		                                                                    
      proceeds from convertible notes payable
    		                                                                    
      purchase of technology in exchange for common stock
    		                                                                    
      conversion of notes payable into series b preferred stock
    		                                                                    
      unrealized loss on marketable securities
    		                                                                    
    The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.