Cytokinetics, Incorporated
(NASDAQ:CYTK)

Cytokinetics, Incorporated, a late-stage biopharmaceutical company, focuses on discovering, developing, and commercializing muscle activators and inhibitors as potential treatments for debilitating diseases. The company is developing small molecule drug candidates primarily engineered to increase mu...

Website: http://www.cytokinetics.com

Founded: 1997

Full Time Employees: 156

Sector: Healthcare

Industry: Biotechnology

Pharmaceuticals

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Unit: USD	2025-12-31	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-12-31	2014-09-30	2014-06-30	2014-03-31	2013-12-31	2013-09-30	2013-06-30	2013-03-31	2012-12-31	2012-09-30	2012-06-30	2012-03-31	2011-09-30	2011-08-05	2010-08-05	2009-08-05	2008-08-05	2008-03-31	2007-12-31	2007-09-30	2007-08-05	2007-06-30	2007-03-31	2006-12-31	2006-09-30	2006-08-05	2006-06-30	2006-03-31	2005-12-31	2005-09-30	2005-08-05	2005-06-30	2005-03-31	2004-12-31	2004-09-30	2004-08-05	2004-06-30	2004-03-31

revenues:
collaboration revenues	2,755,000	1,936,000	2,416,000	1,579,000
license and milestone revenues	15,000,000		64,353,000
total revenues	17,755,000	1,936,000	66,769,000		16,927,000	463,000	249,000	835,000	1,672,000	378,000	867,000	4,613,000	1,957,000	2,515,000	88,968,000	1,148,000	55,600,000	5,437,000	2,843,000	6,548,000	6,722,000	41,688,000	3,593,000	3,825,000	5,212,000	6,055,000	7,137,000	8,464,000	9,377,000	10,641,000	6,215,000	5,268,000	-18,000	6,180,000	3,053,000	4,153,000	33,138,000	59,047,000	5,802,000	8,421,000	9,757,000	7,945,000	6,542,000	4,414,000	21,758,000	9,415,000	7,788,000	7,979,000	24,349,000	4,469,000	1,009,000	821,000	172,260,000	1,714,000	1,841,000	1,820,000	1,427,000					3,069,000	3,110,000	4,130,000		3,177,000	3,205,000	155,000	106,000		1,446,000	1,420,000	2,144,000	1,855,000		2,341,000	2,572,000	2,804,000	2,449,000		2,900,000	5,867,000
yoy	4.89%	318.14%	26714.86%		912.38%	22.49%	-71.28%	-81.90%	-14.56%	-84.97%	-99.03%	301.83%	-96.48%	-53.74%	3029.37%	-82.47%	727.13%	-86.96%	-20.87%	71.19%	28.97%	588.49%	-49.66%	-54.81%	-44.42%	-43.10%	14.84%	60.67%	-52194.44%	72.18%	103.57%	26.85%	-100.05%	-89.53%	-47.38%	-50.68%	239.63%	643.20%	-11.31%	90.78%	-55.16%	-15.61%	-16.00%	-44.68%	-10.64%	110.67%	671.85%	871.86%	-85.86%	160.74%	-45.19%	-54.89%	11971.48%									-3.40%	-2.96%	2564.52%			121.65%	-89.08%	-95.06%			-39.34%	-16.64%	-33.84%			-11.31%	-52.21%
qoq	817.10%	-97.10%			3555.94%	85.94%	-70.18%	-50.06%	342.33%	-56.40%	-81.21%	135.72%	-22.19%	-97.17%	7649.83%	-97.94%	922.62%	91.24%	-56.58%	-2.59%	-83.88%	1060.26%	-6.07%	-26.61%	-13.92%	-15.16%	-15.68%	-9.74%	-11.88%	71.21%	17.98%	-29366.67%	-100.29%	102.42%	-26.49%	-87.47%	-43.88%	917.70%	-31.10%	-13.69%	22.81%	21.45%	48.21%	-79.71%	131.10%	20.89%	-2.39%	-67.23%	444.84%	342.91%	22.90%	-99.52%	9950.18%	-6.90%	1.15%	27.54%						-1.32%	-24.70%			-0.87%	1967.74%	46.23%			1.83%	-33.77%	15.58%			-8.98%	-8.27%	14.50%			-50.57%
operating expenses:
research and development	104,398,000	99,233,000	112,554,000	99,841,000	93,629,000	84,612,000	79,597,000	81,570,000	84,976,000	82,532,000	83,194,000	79,421,000	75,018,000	62,734,000	57,126,000	45,935,000	43,498,000	48,436,000	36,443,000	31,561,000	29,221,000	24,202,000	21,790,000	21,738,000	18,334,000	20,229,000	24,017,000	23,545,000	23,277,000	21,391,000	21,582,000	22,135,000	26,251,000	24,947,000	19,809,000	19,289,000	17,301,000	19,340,000	9,723,000	13,534,000	13,249,000	11,557,000	12,636,000	8,956,000	8,779,000	11,420,000	11,737,000	12,490,000	13,824,000	13,445,000	12,347,000	9,834,000	462,330,000	8,798,000	8,242,000	8,745,000	8,891,000					14,102,000	13,958,000	13,217,000		13,726,000	12,486,000	13,026,000	12,535,000		12,397,000	11,266,000	10,735,000	9,259,000		10,039,000	10,537,000	11,241,000	9,535,000		9,749,000	9,360,000
general and administrative	91,723,000	69,458,000	65,721,000	57,369,000	62,338,000	56,652,000	50,824,000	45,500,000	44,114,000	40,111,000	39,722,000	49,665,000	53,969,000	48,222,000	42,716,000	33,070,000	33,806,000	26,202,000	21,197,000	15,598,000	13,908,000	12,302,000	14,161,000	12,449,000	10,584,000	9,753,000	9,836,000	9,437,000	7,558,000	7,164,000	8,046,000	9,264,000	10,258,000	9,657,000	8,438,000	8,115,000	6,674,000	7,217,000	7,090,000	6,841,000	5,529,000	5,276,000	4,495,000	4,367,000	4,558,000	3,993,000	4,458,000	4,259,000	4,093,000	3,635,000	3,730,000	3,634,000	147,767,000	2,991,000	2,568,000	3,056,000	3,204,000					4,157,000	4,110,000	4,113,000		4,015,000	4,483,000	4,109,000	3,572,000		3,938,000	3,622,000	3,105,000	3,325,000		3,403,000	3,143,000	3,275,000	3,569,000		2,672,000	2,475,000
total operating expenses	196,121,000	168,691,000	178,275,000	157,210,000	155,967,000	141,264,000	130,421,000	127,070,000	129,090,000	122,643,000	122,916,000	129,086,000	128,987,000	110,956,000	99,842,000	79,005,000	77,304,000	74,638,000	57,640,000	47,159,000	43,129,000	36,504,000	35,951,000	34,187,000	28,918,000	29,982,000	33,853,000	32,982,000	30,835,000	28,555,000	29,628,000	31,399,000	36,509,000	34,604,000	28,247,000	27,404,000	23,975,000	26,557,000	16,813,000	20,375,000	18,778,000	16,833,000	17,131,000	13,323,000	13,337,000	15,413,000	16,195,000	16,749,000	17,917,000	17,080,000	16,077,000	13,468,000	613,739,000	11,787,000	10,797,000	11,760,000	12,095,000					18,259,000	18,068,000	17,330,000		17,741,000	16,969,000	17,135,000	16,107,000		16,335,000	14,888,000	13,840,000	12,584,000		13,442,000	13,680,000	9,340,000	13,104,000		12,421,000	11,835,000
operating income	-178,366,000	-166,755,000	-111,506,000	-155,631,000	-139,040,000	-140,801,000	-130,172,000	-126,235,000	-127,418,000	-122,265,000	-122,049,000	-124,473,000	-127,030,000	-108,441,000	-10,874,000	-77,857,000	-21,704,000	-69,201,000	-54,797,000	-40,611,000	-36,407,000	5,184,000	-32,358,000	-30,362,000	-23,706,000	-23,927,000	-26,716,000	-24,518,000	-21,458,000	-17,914,000	-23,413,000	-26,131,000	-36,527,000	-28,424,000	-25,194,000	-23,251,000	9,163,000	32,490,000	-11,011,000	-11,954,000	-9,021,000	-8,888,000	-10,589,000	-8,909,000	8,421,000	-5,998,000	-8,407,000	-8,770,000	6,432,000	-12,611,000	-15,068,000	-12,647,000	-441,479,000	-10,073,000	-8,956,000	-9,940,000	-10,668,000					-15,190,000	-14,958,000	-13,200,000		-14,564,000	-13,764,000	-16,980,000	-16,001,000		-14,889,000	-13,468,000	-11,696,000	-10,729,000		-11,101,000	-11,108,000	-12,290,000	-10,655,000		-9,521,000	-5,968,000
yoy	28.28%	18.43%	-14.34%	23.29%	9.12%	15.16%	6.66%	1.42%	0.31%	12.75%	1022.39%	59.87%	485.28%	56.70%	-80.16%	91.71%	-40.39%	-1434.90%	69.35%	33.76%	53.58%	-121.67%	21.12%	23.84%	10.48%	33.57%	14.11%	-6.17%	-41.25%	-36.98%	-7.07%	12.39%	-498.64%	-187.49%	128.81%	94.50%	-201.57%	-465.55%	3.99%	34.18%	-207.13%	48.18%	25.95%	1.58%	30.92%	-52.44%	-44.21%	-30.66%	-101.46%	25.20%	68.24%	27.23%	4038.35%									4.30%	8.67%	-22.26%			-7.56%	26.08%	36.81%			21.32%	5.29%	-12.70%			16.67%	105.93%
qoq	6.96%	49.55%	-28.35%	11.93%	-1.25%	8.17%	3.12%	-0.93%	4.21%	0.18%	-1.95%	-2.01%	17.14%	897.25%	-86.03%	258.72%	-68.64%	26.29%	34.93%	11.55%	-802.30%	-116.02%	6.57%	28.08%	-0.92%	-10.44%	8.96%	14.26%	19.78%	-23.49%	-10.40%	-28.46%	28.51%	12.82%	8.36%	-353.75%	-71.80%	-395.07%	-7.89%	32.51%	1.50%	-16.06%	18.86%	-205.80%	-240.40%	-28.65%	-4.14%	-236.35%	-151.00%	-16.31%	19.14%	-97.14%	4282.80%	12.47%	-9.90%	-6.82%						1.55%	13.32%			5.81%	-18.94%	6.12%			10.55%	15.15%	9.01%			-0.06%	-9.62%	15.34%			59.53%
operating margin %	-1004.60%	-8613.38%	-167.00%	-Infinity%	-821.41%	-30410.58%	-52277.91%	-15117.96%	-7620.69%	-32345.24%	-14077.16%	-2698.31%	-6491.06%	-4311.77%	-12.22%	-6781.97%	-39.04%	-1272.78%	-1927.44%	-620.20%	-541.61%	12.44%	-900.58%	-793.78%	-454.83%	-395.16%	-374.33%	-289.67%	-228.84%	-168.35%	-376.72%	-496.03%	202927.78%	-459.94%	-825.22%	-559.86%	27.65%	55.02%	-189.78%	-141.95%	-92.46%	-111.87%	-161.86%	-201.84%	38.70%	-63.71%	-107.95%	-109.91%	26.42%	-282.19%	-1493.36%	-1540.44%	-256.29%	-587.69%	-486.47%	-546.15%	-747.58%				NaN%	-494.95%	-480.96%	-319.61%	NaN%	-458.42%	-429.45%	-10954.84%	-15095.28%	NaN%	-1029.67%	-948.45%	-545.52%	-578.38%	NaN%	-474.20%	-431.88%	-438.30%	-435.08%	NaN%	-328.31%	-101.72%
interest expense	-14,274,000	-11,353,000	-11,084,000		-8,938,000	-8,928,000	-12,732,000	-7,103,000	-7,164,000	-7,136,000	-7,045,000	-6,961,000	-7,057,000	-6,804,000	-2,807,000	-2,746,000	-4,218,000	-4,161,000	-4,073,000	-3,988,000	-4,018,000	-3,976,000	-3,892,000	-4,077,000	-2,731,000	-1,345,000	-1,377,000	-1,170,000	-1,169,000	-867,000	-898,000	-863,000	-670,000	-806,000	-782,000	-3,052,000	-713,000	-714,000
non-cash interest expense on liabilities related to revenue participation right purchase agreements	-16,061,000	-14,969,000	-13,181,000	-14,078,000	-13,656,000	-13,370,000	-11,567,000	-10,218,000	-9,900,000	-6,860,000	-6,322,000	-6,280,000	-9,212,000	-8,963,000	-7,003,000	-6,564,000
interest and other income	11,470,000	10,248,000	13,001,000	13,701,000	15,014,000	17,054,000	11,553,000	7,913,000	7,586,000	6,839,000	6,779,000	6,425,000	5,919,000	4,144,000	864,000	415,000	-377,000	231,000	187,000	290,000	2,146,000	1,078,000	1,382,000	723,000	1,330,000	1,020,000			900,000	1,323,000	1,126,000	842,000	774,000	779,000	612,000	436,000	182,000	111,000	-600,000	-501,000																						1,440,000	1,874,000	2,055,000		2,122,000	2,241,000	1,174,000	1,215,000		1,228,000	1,128,000	760,000	756,000		688,000	712,000	-498,000	983,000		780,000	519,000
change in fair value of derivative liabilities	900,000	700,000	3,000,000	-400,000	1,200,000	700,000	-600,000
change in fair value of liabilities related to rpi transactions	13,300,000	-2,800,000	-14,600,000	3,900,000	-4,600,000	-15,200,000	200,000
debt conversion expense		-121,249,000
net income	-183,031,000	-306,178,000	-134,370,000	-161,376,000	-150,020,000	-160,545,000	-143,318,000	-135,643,000	-136,896,000	-129,422,000	-128,637,000	-131,289,000	-137,380,000	-142,310,000	-19,820,000	-89,445,000	-30,570,000	-76,086,000	-61,554,000	-47,104,000	-43,930,000	-3,175,000	-40,780,000	-39,405,000	-30,640,000	-29,573,000	-32,113,000	-29,366,000	-26,468,000	-22,017,000	-27,523,000	-30,281,000	-40,485,000	-32,357,000	-29,081,000	-25,867,000	8,632,000	31,887,000	-11,611,000	-12,455,000	-9,229,000	-8,849,000	-10,551,000	-8,872,000	8,443,000	-5,971,000	-8,374,000	-8,744,000	6,531,000	-12,588,000	-15,041,000	-12,619,000	-419,966,000	-10,044,000	-8,943,000	-9,928,000	-10,639,000					-13,895,000	-13,252,000	-11,321,000		-12,628,000	-11,692,000	-15,946,000	-14,920,000		-13,786,000	-12,464,000	-11,081,000	-10,101,000		-10,540,000	-10,530,000	-11,820,000	-10,216,000		-9,231,000	-5,932,000
yoy	22.00%	90.71%	-6.24%	18.97%	9.59%	24.05%	11.41%	3.32%	-0.35%	-9.06%	549.03%	46.78%	349.39%	87.04%	-67.80%	89.89%	-30.41%	2296.41%	50.94%	19.54%	43.37%	-89.26%	26.99%	34.19%	15.76%	34.32%	16.68%	-3.02%	-34.62%	-31.96%	-5.36%	17.06%	-569.01%	-201.47%	150.46%	107.68%	-193.53%	-460.35%	10.05%	40.39%	-209.31%	48.20%	26.00%	1.46%	29.28%	-52.57%	-44.33%	-30.71%	-101.56%	25.33%	68.19%	27.11%	3847.42%									10.03%	13.34%	-29.00%			-15.19%	27.94%	34.64%			18.25%	5.23%	-14.54%			14.07%	99.26%
qoq	-40.22%	127.86%	-16.73%	7.57%	-6.56%	12.02%	5.66%	-0.92%	5.77%	0.61%	-2.02%	-4.43%	-3.46%	618.01%	-77.84%	192.59%	-59.82%	23.61%	30.68%	7.23%	1283.62%	-92.21%	3.49%	28.61%	3.61%	-7.91%	9.35%	10.95%	20.22%	-20.01%	-9.11%	-25.20%	25.12%	11.27%	12.43%	-399.66%	-72.93%	-374.63%	-6.78%	34.96%	4.29%	-16.13%	18.92%	-205.08%	-241.40%	-28.70%	-4.23%	-233.88%	-151.88%	-16.31%	19.19%	-97.00%	4081.26%	12.31%	-9.92%	-6.68%						4.85%	17.06%			8.01%	-26.68%	6.88%			10.61%	12.48%	9.70%			0.09%	-10.91%	15.70%			55.61%
net income margin %	-1030.87%	-15814.98%	-201.25%	-Infinity%	-886.28%	-34674.95%	-57557.43%	-16244.67%	-8187.56%	-34238.62%	-14837.02%	-2846.07%	-7019.93%	-5658.45%	-22.28%	-7791.38%	-54.98%	-1399.41%	-2165.11%	-719.36%	-653.53%	-7.62%	-1134.98%	-1030.20%	-587.87%	-488.41%	-449.95%	-346.95%	-282.27%	-206.91%	-442.85%	-574.81%	224916.67%	-523.58%	-952.54%	-622.85%	26.05%	54.00%	-200.12%	-147.90%	-94.59%	-111.38%	-161.28%	-201.00%	38.80%	-63.42%	-107.52%	-109.59%	26.82%	-281.67%	-1490.68%	-1537.03%	-243.80%	-586.00%	-485.77%	-545.49%	-745.55%				NaN%	-452.75%	-426.11%	-274.12%	NaN%	-397.48%	-364.80%	-10287.74%	-14075.47%	NaN%	-953.39%	-877.75%	-516.84%	-544.53%	NaN%	-450.23%	-409.41%	-421.54%	-417.15%	NaN%	-318.31%	-101.11%
net income per share	-1.5	-2.55	-1.12	-1.36	-1.26	-1.36	-1.31	-1.33	-1.38	-1.35	-1.34	-1.38	-1.48	-1.52	-0.23	-1.05	-0.32	-0.95	-0.86	-0.66	-0.63	-0.05	-0.68	-0.66	-0.51	-0.5	-0.56	-0.54	-0.368	-0.4	-0.51	-0.56	-0.77	-0.6	-0.6	-0.62	0.21	0.8	-0.29	-0.31	-0.24	-0.23	-0.27	-0.23	0.24	-0.16	-0.23	-0.27	0.28	-0.43	-0.58	-0.09	-0.078	-0.07	-0.13	-0.13	-0.15
weighted-average number of shares used in computing net loss per share — basic and diluted	120,103	119,982	119,457	118,496	111,979	117,685	109,240	101,924	96,524	96,071	95,755	95,164	89,825	93,758	85,731	84,996	76,886	80,329	71,754	71,195	64,524	68,279	59,605	59,270	57,575				54,420						48,218	41,578			39,666	39,592	38,814	38,752	38,725	38,675		36,609
other comprehensive gain:
unrealized gain on available-for-sale securities	235	167			-3,327	6,535	-499	-556	884	584	187	1,945					-804	-43	-72	-99	69.75	-379	-276	934	54.75	-42	155	106	26	3	-39	146	72.25	512	-78	-145
foreign currency translation adjustments	361	25	-852	-312	338	-126	16	27
comprehensive loss	-182,435	-305,986	-136,073	-162,229	-153,009	-154,136	-143,801	-136,172	-136,032	-128,838	-128,450	-129,344	-135,411	-143,375	-20,725	-92,165	-31,374	-76,129	-61,626	-47,203	-44,739	-3,554	-41,056	-38,471	-30,680	-29,615	-31,958	-29,260	-26,415	-22,014	-27,562	-30,135			-29,159	-26,012			-11,538	-12,448	-9,095	-8,847	-10,533	-8,873	8,415	-5,960	-8,374	-8,738	6,519	-12,569	-15,051	-12,627	-419,958	-10,030	-8,942	-9,933
unrealized loss on available-for-sale securities			-851	-541									1,969	-1,065	-905	-2,720
interest and other expense				-8,868,000																																																										-145,000	-168,000	-176,000		-186,000	-169,000	-140,000	-134,000		-125,000	-124,000	-145,000	-128,000		-127,000	-134,000	968,000	-544,000		-490,000	-483,000
research and development revenues					386,750	463,000	249,000	835,000	672,000	378,000	867,000	2,113,000	1,957,000	2,515,000	968,000	1,148,000	744,000	437,000	2,843,000	6,548,000	3,922,000	5,187,000	3,593,000	3,825,000	5,212,000	6,055,000	7,137,000	8,464,000
milestone revenues									1,000,000			2,500,000			1,000,000			5,000,000
realization of revenue participation right purchase agreement															87,000,000
loss on extinguishment of debt																-2,693,000
other comprehensive income:
other comprehensive loss:
loss on settlement of debt														-22,246,000
license revenues																						36,501,000								1,915,000	1,535,000	1,683,000	2,093,000	318,000	4,942,000										2,271,000	2,734,000	2,749,000	2,082,000	2,442,000	1,410,000
non-cash interest expense on liability related to the sale of future royalties																	-2,155,250	-2,955,000	-2,871,000	-2,795,000	-4,265,500	-5,461,000	-5,912,000	-5,689,000	-3,801,000	-5,321,000	-5,064,000	-4,819,000
weighted-average shares in net loss per share — basic and diluted																										58,640	57,648	54,821		54,626	54,293
interest income																											1,044,000	1,141,000
research and development, milestone, grant and other revenues																													4,247,750	8,726,000	4,680,000
non-cash interest expense on liability related to sale of future royalties																													-4,741,000	-4,559,000	-4,338,000	-4,129,000	-4,062,000	-3,906,000	-3,717,000
research and development, grant and other revenues																																3,585,000	-2,111,000	5,862,000	-1,889,000	341,000	312,000	441,000	337,000	151,000	48,000	27,000			3,377,000	4,761,000	4,196,000	5,232,000	4,113,000	2,495,000	446,000	493,000	7,231,000	751,000	746,000	644,000	433,000														2,000	2,000	225,000	300,000		308,000	300,000
weighted-average shares used for eps calculation																																54,062																																									28,582,000					19,756,000
net income before income taxes																																	-21,826,250	-32,357,000			1,955,250	31,887,000
income tax benefit
weighted-average number of shares used in computing net income per share — basic																																	49,404	53,719			39,943	39,926
weighted-average number of shares used in computing net income per share — diluted																																	49,404	53,719			42,561	43,217
comprehensive income																																	-40,568	-31,845			8,517	31,910
research and development revenues from related parties																																				2,366,000	29,611,000	5,573,000	3,515,000	4,296,000	4,578,000	3,786,000	3,510,000	2,791,000	16,110,000	1,920,000	843,000	665,000	564,000	564,000	563,000	328,000	52,094,000	963,000	1,095,000	1,176,000	994,000
license revenues from related parties																																				1,446,000	3,215,000	53,033,000	1,950,000	3,974,000	5,131,000	4,132,000	3,032,000	1,623,000																		3,058,000	3,059,000	3,058,000		3,058,000	3,058,000
net loss before income taxes																																				-25,867,000
unrealized gains on available-for-sale securities																																					-115	23	73	7	134	2	18	-1	-28	11		6
income before income taxes																																							-11,611,000	-12,455,000	-9,229,000	-8,849,000	-10,551,000	-8,872,000	8,443,000	-5,971,000	-8,374,000	-8,744,000	6,531,000	-12,588,000	-15,041,000	-12,619,000	-419,992,000	-10,044,000	-8,943,000	-9,928,000	-10,639,000
interest and other																																									28,500	39,000	38,000	37,000	22,000	27,000	33,000	26,000	99,000	23,000	27,000	28,000	21,487,000	29,000	13,000	12,000	29,000
weighted-average number of shares used in computing net income per share — basic and diluted																																															36,443	32,985
restructuring charges																																																					3,642,000	-2,000	-13,000	-41,000
deemed dividend related to beneficial conversion feature of convertible preferred stock																																																					-2,857,000		-1,307,000
net income allocable to common stockholders																																																	6,531,000	-12,588,000	-15,041,000	-12,619,000	-422,823,000	-10,044,000	-10,250,000	-9,928,000	-10,639,000
weighted-average number of shares used in computing net income per share allocable to common stockholders — basic and diluted																																																	27,275	29,395	25,773	144,061		134,162	81,230		72,280
weighted-average number of shares used in computing net income per common share — basic and diluted																																																								76,082
research and development revenues from related party																																																														11,000	51,000	1,072,000		119,000	147,000	54,000	106,000		744,000	718,000	1,219,000	855,000		1,333,000	1,572,000	1,227,000	1,449,000		1,895,000	5,067,000
net loss per common share — basic and diluted																																																														-280	-270	-240		-270	-250	-410	-410		-380	-360	-390	-350		-370	-370
weighted-average number of shares used in computing net loss per common share — basic and diluted																																																														49,294,000	47,590,000	47,460,000		46,890,000	46,761,000	36,618,000	36,729,000		36,376,000	34,247,000		28,589,000		28,514,000	28,382,000
includes the following stock-based compensation charges:
license revenues from related party																																																																				350,000			700,000	700,000	700,000	700,000		700,000	700,000	700,000	700,000		700,000	700,000
includes the following stock-based compensation charges: - sum																																																																								938,000	272,750	343,000		345,000	402,000				515	389
research and development and grant revenues																																																																														251,250	300,000		305,000	100,000
net income per share	-1.5	-2.55	-1.12	-1.36	-1.26	-1.36	-1.31	-1.33	-1.38	-1.35	-1.34	-1.38	-1.48	-1.52	-0.23	-1.05	-0.32	-0.95	-0.86	-0.66	-0.63	-0.05	-0.68	-0.66	-0.51	-0.5	-0.56	-0.54	-0.368	-0.4	-0.51	-0.56	-0.77	-0.6	-0.6	-0.62	0.21	0.8	-0.29	-0.31	-0.24	-0.23	-0.27	-0.23	0.24	-0.16	-0.23	-0.27	0.28	-0.43	-0.58	-0.09	-0.078	-0.07	-0.13	-0.13	-0.15
basic and diluted																																																																														-0.375	-0.36		-0.46	-2.56
weighted-average number of shares used in per share calculations:
basic and diluted																																																																															28,154,119
includes the following stock based compensation charges:
includes the following stock based compensation charges: - sum																																																																														364.25	553
weighted- average number of shares used in per share calculations:
basic and diluted																																																																																	19,905	2,313

Balance Sheets:

Quarterly

Annual

Unit: USD	2025-12-31	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-12-31	2014-09-30	2014-06-30	2014-03-31	2013-12-31	2013-09-30	2013-06-30	2013-03-31	2012-12-31	2012-09-30	2012-06-30	2012-03-31	2011-12-31	2011-09-30	2011-06-30	2011-03-31	2010-09-30	2010-06-30	2010-03-31	2009-09-30	2009-06-30	2009-03-31	2008-09-30	2008-06-30	2008-03-31	2007-12-31	2007-09-30	2007-06-30	2007-03-31	2006-12-31	2006-09-30	2006-06-30	2006-03-31	2005-12-31	2005-09-30	2005-06-30	2005-03-31	2004-12-31	2004-06-30	2004-03-31

assets
current assets:
cash and cash equivalents	122,518,000	225,467,000	74,940,000	73,680,000	94,857,000	46,888,000	190,142,000	119,976,000	113,024,000	99,692,000	68,639,000	101,616,000	65,582,000	106,238,000	93,631,000	115,422,000	112,666,000	90,562,000	37,154,000	44,594,000	82,985,000	200,812,000	61,134,000	49,776,000	36,433,000	39,634,000	34,361,000	39,409,000	42,256,000	27,624,000	46,955,000	115,011,000	125,206,000	116,320,000	100,711,000	49,364,000	66,874,000	30,300,000	27,724,000	42,269,000	65,076,000	25,962,000	24,839,000	22,546,000	20,215,000	12,907,000	12,355,000	13,256,000	20,158,000	19,258,000	17,057,000	13,160,000	14,907,000	15,390,000	63,654,000	17,815,000	18,833,000	18,591,000	23,769,000	15,452,000	30,439,000	18,365,000	20,715,000	23,715,000	85,032,000	48,489,000	70,636,000	86,861,000	105,540,000	116,564,000	108,491,000	111,223,000	104,048,000	39,387,000	48,214,000	49,766,000	73,111,000	13,515,000	11,803,000	10,910,000	14,816,000	13,061,000	17,650,000	8,916,000
short-term investments	759,703,000	737,068,000	783,195,000	864,538,000	981,157,000	964,804,000	866,633,000	498,985,000	501,800,000	439,547,000	497,083,000	562,346,000	716,995,000	761,426,000	492,395,000	493,552,000	358,972,000	387,074,000	313,147,000	380,983,000	381,075,000	209,452,000	151,929,000	170,930,000	188,679,000	126,405,000	138,507,000	137,213,000	156,475,000	182,686,000	184,986,000	136,443,000	143,685,000	191,247,000	211,340,000	157,192,000	89,375,000	48,309,000	62,614,000	61,153,000	46,366,000	72,023,000	80,344,000	85,322,000	63,013,000	65,589,000	65,395,000	69,090,000	57,570,000	62,384,000	58,596,000	48,438,000	59,093,000	60,220,000	26,821,000	25,265,000	30,190,000	38,994,000	43,143,000	44,449,000	46,780,000	61,739,000	67,091,000	79,723,000	29,691,000	15,607,000				3,175,000	44,450,000	44,250,000	65,499,000	70,155,000	40,478,000	45,155,000	28,150,000	62,697,000	68,761,000	78,191,000	86,809,000	92,637,000	102,269,000	18,941,000
accounts receivable	17,764,000	1,808,000	8,410,000	2,012,000	16,650,000	244,000		834,000	1,283,000	2,499,000	985,000	1,006,000	147,000	2,294,000	1,973,000	6,056,000	51,819,000	644,000	2,701,000	4,514,000	4,420,000	4,965,000	2,254,000	2,704,000	5,163,000	6,576,000	8,993,000	4,165,000	2,231,000	9,156,000	236,000	37,000	1,112,000	10,000,000																																																	13,000
prepaid expenses and other current assets	16,990,000	13,006,000	19,997,000	15,823,000	15,276,000	6,665,000	11,035,000	18,909,000	11,944,000	19,678,000	19,868,000	15,661,000	12,462,000	14,317,000	14,251,000	8,496,000	12,215,000	16,661,000	11,227,000	3,026,000	5,741,000	3,183,000	3,637,000	2,528,000	3,477,000
total current assets	916,975,000	977,349,000	886,542,000	956,053,000	1,107,940,000	1,018,601,000	1,067,810,000	638,704,000	628,051,000	561,416,000	586,575,000	680,629,000	795,186,000	884,275,000	602,250,000	623,526,000	535,672,000	494,941,000	364,229,000	433,117,000	474,221,000	418,412,000	218,954,000	225,938,000	233,752,000	176,535,000	184,951,000	186,400,000	207,674,000	227,269,000	244,229,000	272,339,000	274,295,000	321,987,000	316,996,000	211,023,000	158,633,000	148,184,000	96,618,000	106,118,000	113,107,000	100,515,000	107,900,000	110,810,000	131,131,000	81,491,000	80,078,000	86,054,000	79,338,000	83,321,000	93,620,000	63,665,000	76,427,000	78,769,000	92,960,000	45,221,000	51,140,000	59,871,000	69,804,000	62,954,000	79,258,000	90,139,000	107,089,000	128,151,000	137,100,000	65,332,000	72,783,000	89,335,000	107,510,000	122,016,000	155,205,000	158,021,000	171,660,000	153,621,000	91,413,000	97,590,000	103,107,000	78,864,000	83,655,000	92,282,000	104,825,000		122,777,000	31,131,000
long-term investments	335,048,000	288,817,000	178,201,000	150,687,000	145,055,000	269,168,000	305,361,000	15,376,000	40,534,000	15,468,000	26,871,000	40,406,000	46,708,000	28,544,000	10,668,000	77,083,000	152,050,000	191,295,000	73,672,000	34,664,000	36,954,000	40,958,000		16,510,000	42,650,000		2,254,000					4,015,000	16,518,000	583,000	20,087,000	50,622,000	7,672,000	7,737,000	7,684,000	5,140,000	179,000		3,035,000	9,653,000		4,003,000	14,352,000	19,515,000	2,502,000	3,754,000				5,543,000													18,230,000	18,749,000	19,082,000	20,025,000												4,555,000	11,550,000	7,789,000
property and equipment	79,194,000	76,001,000	70,219,000	67,175,000	65,815,000	64,222,000	65,689,000	68,018,000	68,748,000	75,614,000	77,248,000	78,859,000	80,453,000	80,302,000	78,586,000	75,740,000	73,271,000	53,896,000	36,942,000	23,198,000	13,346,000	7,667,000	5,611,000	5,162,000	4,530,000	3,615,000	2,945,000	3,175,000	3,204,000	2,687,000	2,598,000	3,156,000	3,568,000	3,294,000	3,268,000	3,488,000	3,637,000	2,049,000	1,659,000	1,760,000	1,751,000	1,481,000	1,571,000	1,551,000	1,637,000	1,491,000	1,513,000	1,508,000	1,221,000	804,000	809,000	898,000	997,000	906,000	994,000	1,132,000	1,310,000	1,514,000	1,705,000	2,041,000	2,574,000	2,953,000	3,282,000	3,865,000	4,249,000	4,714,000	5,605,000	6,728,000	7,201,000	7,728,000	7,820,000	8,132,000	8,667,000	9,202,000	7,178,000	5,920,000	5,949,000	6,178,000	5,920,000	6,368,000	6,727,000	7,336,000	7,764,000	8,170,000
operating lease right-of-use assets	75,979,000	77,580,000	76,120,000	77,439,000	75,158,000	76,344,000	77,249,000	78,170,000	78,987,000	79,929,000	80,866,000	81,802,000	82,737,000	75,076,000	72,161,000	72,646,000	73,138,000	80,725,000	83,006,000	79,687,000
other assets	17,341,000	16,810,000	14,553,000	12,697,000	7,705,000	7,725,000	7,679,000	7,814,000	7,996,000	8,187,000	8,339,000	8,119,000	9,691,000	7,764,000	8,052,000	7,258,000	7,188,000	6,682,000	6,453,000	6,396,000						7,243,000	8,068,000	9,036,000	300,000	323,000	412,000	416,000	429,000	449,000	279,000	241,000	200,000	200,000	200,000	200,000	200,000	200,000	200,000	200,000	200,000	200,000	200,000	200,000	127,000	127,000	126,000	127,000	127,000	127,000	127,000	127,000	127,000	178,000	209,000	228,000	298,000	291,000	289,000	296,000	310,000	327,000	372,000	368,000	349,000	335,000	324,000	318,000	317,000	367,000	442,000	526,000	615,000	796,000	818,000	814,000	794,000	776,000	743,000	734,000
total assets	1,424,537,000	1,436,557,000	1,225,635,000	1,264,051,000	1,401,673,000	1,436,060,000	1,523,788,000	808,082,000	824,316,000	740,614,000	779,899,000	889,815,000	1,014,775,000	1,075,961,000	771,717,000	856,253,000	841,319,000	827,539,000	564,302,000	577,062,000	533,803,000	474,112,000	232,495,000	256,582,000	289,814,000	187,393,000	198,218,000	198,611,000	211,178,000	230,279,000	247,239,000	279,926,000	294,810,000	326,313,000	340,630,000	265,374,000	170,142,000	158,170,000	106,161,000	113,218,000	115,237,000	102,196,000	112,706,000	122,214,000	132,968,000	87,185,000	96,143,000	107,277,000	83,188,000	88,006,000	94,555,000	64,690,000	77,551,000	85,345,000	94,081,000	46,531,000	52,773,000	61,778,000	72,157,000	65,662,000	82,918,000	94,616,000	111,893,000	134,164,000	144,069,000	92,922,000	100,043,000	119,366,000	138,338,000	155,370,000	168,702,000	172,812,000	186,995,000	169,516,000	104,649,000	109,578,000	114,668,000	91,461,000	95,901,000	105,202,000	117,832,000		149,503,000	56,169,000
liabilities and stockholders’ deficit
current liabilities:
accounts payable	22,337,000	22,084,000	16,228,000	13,942,000	20,369,000	11,581,000	9,470,000	12,967,000	21,507,000	13,796,000	12,561,000	17,357,000	25,611,000	14,429,000	14,078,000	19,836,000	21,087,000	16,222,000	14,928,000	7,766,000	8,050,000	6,738,000	2,920,000	3,527,000	8,160,000	3,412,000	5,194,000	2,547,000	3,764,000	2,024,000	1,336,000	2,424,000	5,253,000	4,079,000	1,783,000	3,042,000	4,236,000	668,000	2,846,000	547,000	2,238,000	1,907,000	1,601,000	1,392,000	1,361,000	1,646,000	985,000	1,689,000	3,709,000	1,789,000	1,801,000	1,086,000	2,002,000	1,518,000	1,046,000	926,000	1,196,000	1,450,000	1,005,000	1,045,000	1,013,000	1,196,000	1,700,000	1,349,000	924,000	1,256,000	1,013,000	1,659,000	2,306,000	1,584,000	2,505,000	2,221,000	1,815,000	2,838,000	2,448,000	1,890,000	1,617,000	2,352,000	1,366,000	773,000	1,252,000	2,059,000	1,926,000	1,032,000
accrued liabilities	83,278,000	61,633,000	52,315,000	43,358,000	55,323,000	49,826,000	39,813,000	40,123,000	42,641,000	32,954,000	31,470,000	35,632,000	44,096,000	40,229,000	36,702,000	29,477,000	34,370,000	31,772,000	22,394,000	14,806,000	19,315,000	14,486,000	13,688,000	9,677,000	12,123,000	13,139,000	11,828,000	12,944,000	15,757,000	15,652,000	16,090,000	15,545,000	17,392,000	18,455,000	13,545,000	17,503,000	18,047,000	17,783,000	9,503,000	7,877,000	8,421,000	6,759,000	6,429,000	3,981,000	5,400,000	6,012,000	6,911,000	7,678,000	8,272,000	9,886,000	6,706,000	4,690,000	4,877,000	2,942,000	2,943,000	3,541,000	3,232,000	3,263,000	3,737,000	4,279,000	4,446,000	4,411,000	4,281,000	6,207,000	8,230,000	6,569,000	8,750,000	8,024,000	8,190,000	8,558,000	7,292,000	5,740,000	5,647,000	7,466,000	6,424,000	5,502,000	4,215,000	4,137,000	4,282,000	3,994,000	3,780,000	3,697,000	2,918,000	3,407,000
short-term operating lease liabilities	19,111,000	20,647,000	19,585,000	19,574,000	18,978,000	18,856,000	18,507,000	18,230,000	17,891,000	17,236,000	15,701,000	14,263,000	12,829,000	16,056,000	14,303,000	14,490,000	14,863,000
current portion of convertible and long-term debt	41,181,000
derivative liabilities measured at fair value	31,100,000	16,900,000	17,600,000	11,700,000	11,300,000	12,500,000	13,200,000
deferred revenue	1,612,000	1,612,000	1,344,000	52,370,000	52,370,000																																																						263,000	17,000			217,000								12,234,000	12,234,000	12,234,000				700,000
other current liabilities	3,833,000	1,988,000	9,592,000	5,822,000	9,814,000	5,529,000	10,267,000	6,015,000	10,559,000	13,737,000	5,885,000	7,968,000	2,081,000	5,782,000	1,760,000	3,044,000	1,540,000	2,413,000	1,004,000	2,438,000	1,049,000	2,406,000	1,013,000	2,507,000	1,124,000	389,000	399,000	75,000	66,000	38,000	28,000	235,000	227,000	424,000	474,000
total current liabilities	202,452,000	142,144,000	131,064,000	159,726,000	179,674,000	109,812,000	102,777,000	88,855,000	102,678,000	77,723,000	65,617,000	75,220,000	84,617,000	76,496,000	66,843,000	66,847,000	71,860,000	80,868,000	61,766,000	35,930,000	31,199,000	27,573,000	22,696,000	20,741,000	26,023,000	21,517,000	21,959,000	26,277,000	22,194,000	21,492,000	27,289,000	38,546,000	32,444,000	42,357,000	31,059,000	36,796,000	33,258,000	29,334,000	26,272,000	24,683,000	31,649,000	30,143,000	29,112,000	25,385,000	23,855,000	12,986,000	16,917,000	19,792,000	26,704,000	45,011,000	34,046,000	5,819,000	7,105,000	4,589,000	3,989,000	4,467,000	4,592,000	5,034,000	5,505,000	6,042,000	6,487,000	6,875,000	17,534,000	20,469,000	23,248,000	22,062,000	24,467,000	24,952,000	26,294,000	26,448,000	26,238,000	24,388,000	23,850,000	26,393,000	12,405,000	10,650,000	9,685,000	11,264,000	10,764,000	10,476,000	12,097,000		10,468,000	9,231,000
term loans	246,384,000	158,747,000	159,058,000	92,025,000	93,227,000	93,017,000	92,831,000
convertible notes	869,597,000	889,524,000	553,987,000	553,143,000	552,370,000	551,481,000	550,600,000	549,790,000	548,989,000	548,134,000	547,288,000	546,513,000	545,808,000	544,986,000	134,674,000	134,511,000	95,471,000	93,885,000	92,348,000	90,889,000	89,504,000	88,102,000	86,743,000	85,455,000	84,205,000
liabilities related to revenue participation right purchase agreements	520,559,000	504,498,000	489,503,000	476,296,000	462,192,000	448,509,000	435,112,000	390,219,000	379,975,000	370,049,000	313,163,000	306,814,000	300,501,000	291,260,000	282,266,000	275,235,000
long-term operating lease liabilities	107,970,000	110,655,000	111,028,000	113,353,000	112,582,000	114,752,000	116,718,000	118,554,000	120,427,000	122,216,000	123,829,000	125,341,000	126,895,000	114,405,000	112,732,000	112,023,000	112,229,000
liabilities related to rpi transactions measured at fair value	137,200,000	150,500,000	147,700,000	133,100,000	137,000,000	132,400,000	117,200,000
total liabilities	2,084,162,000	1,957,680,000	1,594,355,000	1,530,464,000	1,537,045,000	1,449,971,000	1,415,238,000	1,204,242,000	1,210,639,000	1,179,415,000	1,113,014,000	1,118,835,000	1,122,675,000	1,091,938,000	660,303,000	739,992,000	597,456,000	578,519,000	547,813,000	509,216,000	420,420,000	324,507,000	310,575,000	302,293,000	300,751,000	207,262,000	203,114,000	195,239,000	185,244,000	178,210,000	172,069,000	180,327,000	184,968,000	179,275,000	165,629,000	169,991,000	75,781,000	74,920,000	57,415,000	55,312,000	46,647,000	34,896,000	37,845,000	38,062,000	40,904,000	13,555,000	17,446,000	21,099,000	28,746,000	48,255,000	42,566,000	6,260,000	7,466,000	4,742,000	4,100,000	4,524,000	4,595,000	5,034,000	5,505,000	6,076,000	6,796,000	7,364,000	18,258,000	21,807,000	25,005,000	45,726,000	42,739,000	46,778,000	51,714,000	55,454,000	59,204,000	61,475,000	65,046,000	63,203,000	19,059,000	16,786,000	15,618,000	17,900,000	17,678,000	17,344,000	20,287,000		21,478,000	20,330,000
commitments and contingencies
stockholders' deficit
preferred stock, 0.001 par value:
authorized: 10,000,000 shares; issued and outstanding: none
common stock		122,000	119,000	119,000		118,000	117,000	105,000		94,000	94,000	94,000		93,000	85,000	85,000		84,000	72,000	71,000		70,000	60,000	59,000		59,000	58,000	55,000		55,000	55,000	54,000																						142,000	133,000												49,000	49,000	49,000		49,000	47,000	47,000
authorized: 326,000,000 shares
issued and outstanding: 122,943,172 shares at december 31, 2025 and 118,209,139 shares at december 31, 2024	123,000
additional paid-in capital	2,826,341,000	2,782,409,000	2,628,829,000	2,595,063,000	2,563,876,000	2,532,328,000	2,500,654,000	1,852,155,000	1,725,823,000	1,537,321,000	1,514,169,000	1,489,814,000	1,481,590,000	1,438,103,000	1,422,127,000	1,406,249,000	1,452,268,000	1,426,051,000	1,117,403,000	1,107,135,000	1,105,470,000	1,096,953,000	865,724,000	857,038,000	853,341,000	813,729,000	799,088,000	775,401,000	768,703,000	765,970,000	762,887,000	757,405,000	755,526,000	752,154,000	748,273,000	639,507,000	612,474,000	609,880,000	607,287,000	604,909,000	603,145,000	592,760,000	591,476,000	590,234,000	589,272,000	579,255,000	578,363,000	577,470,000	537,001,000	528,831,000	528,501,000	519,772,000	518,804,000	517,872,000	517,229,000	460,369,000	456,610,000	453,296,000	452,559,000	431,872,000	425,087,000	423,881,000	417,132,000	411,106,000	409,639,000	393,730,000	384,163,000	382,730,000	381,137,000	379,730,000	376,218,000	366,936,000	365,073,000	338,078,000	301,677,000	294,336,000	287,074,000	249,521,000	243,466,000	243,452,000	243,051,000	243,239,000	242,572,000	7,596,000
accumulated other comprehensive income	630,000	34,000	-158,000	1,545,000	2,398,000	5,387,000											-869,000	-65,000	-22,000	50,000	149,000	958,000	1,337,000	1,613,000	679,000	719,000	761,000	606,000	500,000	447,000	450,000	489,000	343,000	426,000	-86,000	-9,000	137,000	252,000	229,000	156,000	149,000	16,000	12,000		-4,000	24,000	12,000	12,000	7,000	19,000	-1,000	10,000	18,000	13,000	-1,000	-2,000	3,000	8,000	15,000	9,000	7,000	3,000	-7,000	24,000	-3,000	4,000																-188,000	-89,000	67,000
accumulated deficit	-3,486,719,000	-3,303,688,000	-2,997,510,000	-2,863,140,000	-2,701,764,000	-2,551,744,000	-2,391,199,000	-2,247,881,000	-2,112,238,000	-1,975,342,000	-1,845,920,000	-1,717,283,000	-1,585,994,000	-1,448,614,000	-1,306,304,000	-1,286,484,000	-1,207,620,000	-1,177,050,000	-1,100,964,000	-1,039,410,000	-992,306,000	-948,376,000	-945,201,000	-904,421,000	-865,016,000	-834,376,000	-804,803,000	-772,690,000	-743,324,000	-714,403,000	-688,222,000	-658,349,000	-646,081,000	-605,596,000	-573,239,000	-544,158,000	-518,291,000	-526,923,000	-558,810,000	-547,199,000	-534,744,000	-525,515,000	-516,666,000	-506,115,000	-497,243,000	-505,686,000	-499,715,000	-491,340,000	-482,597,000
total stockholders' deficit	-659,625,000	-521,123,000	-368,720,000	-266,413,000	-135,372,000	-13,911,000
total liabilities and stockholders' deficit	1,424,537,000	1,436,557,000	1,225,635,000	1,264,051,000	1,401,673,000	1,436,060,000
current portion of long-term debt		17,280,000	14,400,000	12,960,000	11,520,000	11,520,000	11,520,000	11,520,000	10,080,000									16,875,000	11,250,000	5,625,000								6,212,000	2,607,000	3,778,000	1,703,000			9,829,000	7,315,000	4,825,000	2,500,000
other non-current liabilities		1,612,000	2,015,000	2,821,000				2,000	186,000	408,000	625,000	837,000	1,044,000	1,247,000	1,444,000	3,211,000	4,457,000
preferred stock
authorized: 163,000,000 shares
issued and outstanding: 118,209,139 shares at december 31, 2024 and 101,637,922 shares at december 31, 2023					118,000
liabilities and stockholders’ equity
stockholders’ equity
accumulated other comprehensive loss							-1,022,000	-539,000	-10,000	-874,000	-1,458,000	-1,645,000	-3,590,000	-5,559,000	-4,494,000	-3,589,000																												-6,000																							-1,795,000	-1,276,000	-948,000	-1,000	-13,000	-60,000	-54,000	-75,000	-22,000	-56,000		-14,000	-43,000	-95,000	-181,000
total stockholders’ equity							108,550,000								111,414,000	116,261,000	243,863,000	249,020,000	16,489,000	67,846,000	113,383,000	149,605,000			-10,937,000	-19,869,000	-4,896,000	3,372,000	25,934,000	52,069,000	75,170,000	99,599,000	109,842,000	147,038,000	175,001,000	95,383,000	94,361,000	83,250,000	48,746,000	57,906,000	68,590,000	67,300,000	74,861,000	84,152,000	92,064,000	73,630,000	78,697,000	86,178,000	54,442,000	39,751,000	51,989,000	58,430,000	70,085,000	80,603,000	89,981,000	42,007,000	48,178,000	56,744,000	66,652,000	59,586,000	76,122,000	87,252,000	93,635,000	112,357,000	119,064,000	47,196,000	57,304,000	72,588,000	86,624,000	99,916,000	109,498,000	111,337,000	121,949,000	106,313,000	85,560,000	92,792,000	99,050,000	73,561,000	78,223,000	87,858,000	97,545,000		128,025,000
total liabilities and stockholders’ equity							1,523,788,000								771,717,000	856,253,000	841,319,000	827,539,000	564,302,000	577,062,000	533,803,000	474,112,000			289,814,000	187,393,000	198,218,000	198,611,000	211,178,000	230,279,000	247,239,000	279,926,000	294,810,000	326,313,000	340,630,000	265,374,000	170,142,000	158,170,000	106,161,000	113,218,000	115,237,000	102,196,000	112,706,000	122,214,000	132,968,000	87,185,000	96,143,000	107,277,000	83,188,000	88,006,000	94,555,000	64,690,000	77,551,000	85,345,000	94,081,000	46,531,000	52,773,000	61,778,000	72,157,000	65,662,000	82,918,000	94,616,000	111,893,000	134,164,000	144,069,000	92,922,000	100,043,000	119,366,000	138,338,000	155,370,000	168,702,000	172,812,000	186,995,000	169,516,000	104,649,000	109,578,000	114,668,000		95,901,000	105,202,000	117,832,000
term loan								56,822,000	58,384,000	60,885,000	62,492,000	64,110,000	63,810,000	63,544,000	62,344,000	61,165,000	47,367,000	30,203,000	35,538,000	40,874,000	46,209,000	45,920,000	45,631,000	45,340,000	45,052,000
stockholders’ deficit:
total stockholders’ deficit								-396,160,000	-386,323,000	-438,801,000	-333,115,000	-229,020,000											-78,080,000	-45,711,000																																																												-97,333,000
total liabilities and stockholders’ deficit								808,082,000	824,316,000	740,614,000	779,899,000	889,815,000											232,495,000	256,582,000
issued and outstanding: 101,637,922 shares at december 31, 2023 and 94,833,975 shares at december 31, 2022									102,000
preferred stock, 0.001 par value
liabilities and stockholders’ (deficit) equity
long-term deferred revenue																87,000,000	87,000,000	87,000,000	87,000,000	87,000,000	87,000,000
stockholders’ (deficit) equity:
issued and outstanding: 94,833,975 shares at december 31, 2022 and 84,799,542 shares at december 31, 2021													94,000
total stockholders’ (deficit) equity													-107,900,000	-15,977,000
total liabilities and stockholders’ (deficit) equity													1,014,775,000	1,075,961,000
revenues:
research and development revenues													6,588,000
license revenues
milestone revenues													1,000,000
realization of revenue participation right purchase agreement													87,000,000
total revenues													94,588,000
operating expenses:
research and development													240,813,000
general and administrative													177,977,000
total operating expenses													418,790,000
operating income													-324,202,000
interest expense													-19,414,000
loss on settlement of debt													-24,939,000
non-cash interest expense on liabilities related to revenue participation right purchase agreements													-31,742,000
interest and other income													11,342,000
net income													-388,955,000
net income per share													-4,330
weighted-average number of shares used in computing net income per share — basic and diluted													89,825,000
other comprehensive loss:
unrealized loss on available-for-sale securities													-2,721,000
comprehensive loss													-391,676,000
stockholders’ equity:
liabilities related to revenue participation right purchase agreement																	179,072,000
issued and outstanding: 84,799,542 shares at december 31, 2021 and 71,015,183 shares at december 31, 2020																	84,000
short-term lease liabilities																		13,586,000	12,190,000	5,295,000
liability related to the sale of future royalties																		174,775,000	171,790,000	168,890,000	166,068,000	160,395,000	154,914,000	148,983,000	143,276,000	137,726,000	132,388,000	127,308,000	122,473,000	117,718,000	113,144,000	108,792,000	104,650,000	100,575,000	96,657,000	92,928,000
long-term lease and other non-current liabilities																		111,788,000	99,371,000		440,000	2,517,000
long-term lease liabilities																				85,633,000
operating lease right-of-use assets and other assets																					9,282,000	7,075,000	7,930,000	8,972,000	8,882,000
short-term lease liability																					2,785,000	3,943,000	5,075,000	5,030,000	4,616,000	4,577,000	4,538,000	4,499,000
issued and outstanding: 71,015,183 shares at december 31, 2020 and 59,172,124 shares at december 31, 2019																					70,000
long-term lease liability																							591,000	1,774,000	2,195,000	3,257,000	4,294,000	5,272,000
contract assets																											575,000	2,472,000	4,554,000	5,876,000	10,375,000	18,550,000
issued and outstanding: 59,172,124 shares at december 31, 2019 and 54,717,906 shares at december 31, 2018																									59,000
prepaid and other current assets																										3,920,000	2,515,000	3,141,000	2,158,000	1,927,000	1,677,000	2,298,000	4,292,000	4,420,000	4,945,000	3,557,000	2,360,000	2,575,000	6,254,000	2,696,000	1,653,000	2,483,000	2,713,000	1,972,000	1,257,000	1,804,000	2,009,000	1,592,000	1,605,000	1,679,000	1,967,000	1,739,000	2,423,000	3,159,000	2,482,000	2,058,000	2,103,000	2,170,000	2,865,000	3,019,000	1,777,000	2,349,000	1,613,000	2,010,000	1,840,000	1,189,000	2,001,000	2,337,000	1,735,000	2,063,000	2,007,000	2,356,000	1,754,000	1,848,000	2,498,000	2,438,000	1,645,000	1,925,000	1,768,000	2,572,000	2,419,000	2,603,000
long-term debt																										44,762,000	44,473,000	36,382,000	39,806,000	38,127,000	30,662,000	31,954,000	31,777,000	20,471,000	22,844,000	25,195,000	27,381,000	29,742,000	29,604,000	29,466,000	14,639,000
other long-term liabilities																													771,000	873,000	974,000	1,035,000	1,097,000		2,000
deferred revenue, current																																4,506,000	9,572,000	9,570,000	7,942,000	10,974,000	8,060,000	10,497,000	13,559,000	15,911,000	20,858,000	21,367,000	20,993,000	19,942,000	17,042,000	5,284,000	8,984,000	10,396,000	14,701,000	33,322,000	25,529,000
deferred revenue, non-current																																	15,000,000	15,872,000	15,067,000	15,000,000	15,000,000	15,635,000	1,275,000	851,000		4,346,000	8,293,000	12,211,000	16,558,000	52,000		772,000	1,500,000	2,696,000	8,000,000
issued and outstanding: 54,717,906 shares at december 31, 2018 and 53,960,832 shares at december 31, 2017																													55,000
contract liabilities																															8,132,000	15,836,000
authorized: 163,000,000
issued and outstanding: 53,960,832 shares at december 31, 2017 and 40,646,595 shares at december 31, 2016																																	54,000
authorized: 10,000,000 shares;
issued and outstanding: series a convertible preferred stock — zero shares at september 30, 2017 and december 31, 2016
authorized: 163,000,000 shares;
issued and outstanding: 53,862,617 shares at september 30, 2017 and 40,646,595 shares at december 31, 2016																																		54,000
issued and outstanding: series a convertible preferred stock — zero shares at june 30, 2017 and december 31, 2016
issued and outstanding: 53,457,091 shares at june 30, 2017 and 40,646,595 shares at december 31, 2016																																			53,000
related party accounts receivable																																				910,000	24,000	67,000,000	26,000		12,000	47,000	4,000	970,000	46,646,000				5,000			328,000	4,000		3,000	83,000	14,000	116,000	27,000	34,000	262,000	211,000	11,000	4,544,000	522,000	7,000	69,000	60,000	58,000	87,000	130,000	65,000	133,000	42,071,000	63,000	71,000	50,000	576,000	984,000	211,000	131,000	53,000		204,000
short-term portion of deferred rent and interest payable																																				452,000	415,000	386,000	364,000	348,000
long-term portion of deferred rent																																				72,000	142,000	209,000	264,000	312,000	359,000	407,000	440,000	466,000	491,000	517,000	529,000	535,000	542,000	548,000	520,000	441,000	361,000	153,000	111,000	57,000	3,000
issued and outstanding: series a convertible preferred stock — zero shares at march 31, 2017 and december 31, 2016
issued and outstanding: 43,417,342 shares at march 31, 2017 and 40,646,595 shares at december 31, 2016																																				43,000
issued and outstanding: series a convertible preferred stock — zero shares at december 31, 2016 and december 31, 2015
authorized: 163,000,000 shares at december 31, 2016 and 81,500,000 shares at december 31, 2015;
issued and outstanding: 40,646,595 shares at december 31, 2016 and 39,581,692 shares at december 31, 2015																																					41,000
issued and outstanding: series a convertible preferred stock — zero shares at september 30, 2016 and december 31, 2015
authorized: 81,500,000 shares;
issued and outstanding: 40,516,892 shares at september 30, 2016 and 39,581,692 shares at december 31, 2015																																						41,000
issued and outstanding: series a convertible preferred stock — zero shares at june 30, 2016 and december 31, 2015
issued and outstanding: 39,697,508 shares at june 30, 2016 and 39,581,692 shares at december 31, 2015																																							40,000
issued and outstanding: series a convertible preferred stock — zero shares at march 31, 2016 and december 31, 2015
issued and outstanding: 39,607,437 shares at march 31, 2016 and 39,581,692 shares at december 31, 2015																																								40,000
short-term portion of deferred rent																																									132,000	110,000	89,000	70,000	52,000	44,000	37,000	29,000	22,000	14,000	10,000	43,000	76,000
issued and outstanding: series a convertible preferred stock — zero shares at december 31, 2015 and december 31, 2014
issued and outstanding: 39,581,692 shares at december 31, 2015 and 38,659,738 shares at december 31, 2014																																									40,000
issued and outstanding: series a convertible preferred stock — zero shares at september 30, 2015 and december 31, 2014
issued and outstanding: 38,756,313 shares at september 30, 2015 and 38,659,738 shares at december 31, 2014																																										39,000
issued and outstanding: series a convertible preferred stock — zero shares at june 30, 2015 and december 31, 2014
issued and outstanding: 38,728,921 shares at june 30, 2015 and 38,659,738 shares at december 31, 2014																																											39,000
issued and outstanding: series a convertible preferred stock — zero shares at march 31, 2015 and december 31, 2014
issued and outstanding: 38,716,905 shares at march 31, 2015 and 38,659,738 shares at december 31, 2014																																												39,000
issued and outstanding: series a convertible preferred stock — zero shares at december 31, 2014 and december 31, 2013
issued and outstanding: 38,659,738 shares at december 31, 2014 and 30,681,624 shares at december 31, 2013																																													39,000
accounts receivable and related party receivable																																														1,191,000	319,000	2,116,000
authorized: 10,000,000 shares; issued and outstanding, none
issued and outstanding: 36,608,781 shares at september 30, 2014 and 30,681,624 shares at december 31, 2013																																														37,000
issued and outstanding: 36,608,781 shares at june 30, 2014 and 30,681,624 shares at december 31, 2013																																															37,000
issued and outstanding: 36,090,071 shares at march 31, 2014 and 30,681,624 shares at december 31, 2013																																																36,000
related party payables and accrued liabilities																																																					150,000				12,000	11,000	11,000	11,000			10,000	10,000	10,000	15,000	10,000	6,000	22,000	22,000	36,000	76,000	115,000	164,000	216,000	268,000	390,000	649,000
authorized: 10,000,000 shares ; issued and outstanding:
series a convertible preferred stock — zero shares at december 31, 2013 and december 31, 2012
series b convertible preferred stock — zero shares at december 31, 2013 and 23,026 shares at december 31, 2012
issued and outstanding: 30,681,624 shares at december 31, 2013 and 23,742,911 shares at december 31, 2012																																																	31,000
issued and outstanding: series b convertible preferred stock — 0 shares at september 30, 2013 and 23,026 shares at december 31, 2012
issued and outstanding: 29,503,123 shares at september 30, 2013 and 23,742,911 shares at december 31, 2012																																																		29,000
deficit accumulated during the development stage																																																		-489,128,000	-476,540,000	-461,499,000	-448,880,000	-437,424,000	-427,380,000	-418,438,000	-408,510,000	-396,632,000	-385,994,000	-372,362,000	-349,037,000	-336,696,000	-323,552,000	-298,834,000	-290,633,000	-346,592,000	-325,051,000	-308,791,000	-293,427,000	-279,533,000	-266,280,000	-254,959,000	-242,331,000	-230,639,000	-214,693,000	-199,773,000	-185,987,000	-173,524,000	-162,443,000	-152,342,000	-141,802,000	-131,272,000	-109,237,000	-100,006,000
license fee receivable																																																			16,000,000
issued and outstanding: series b convertible preferred stock — 4,000 shares at june 30, 2013 and 23,026 shares at december 31, 2012
issued and outstanding: 28,685,215 shares at june 30, 2013 and 23,742,911 shares at december 31, 2012																																																			29,000
authorized: 10,000,000 shares; issued and outstanding:
series b convertible preferred stock — 19,026 shares at march 31, 2013 and 23,026 shares at december 31, 2012
authorized: 245,000,000 shares;
issued and outstanding: 146,463,469 shares at march 31, 2013 and 142,457,469 shares at december 31, 2012																																																				147,000
restricted cash																																																								51,000	196,000	215,000	439,000	439,000	788,000	1,233,000	1,233,000	1,674,000	2,232,000	2,232,000	2,750,000	4,147,000	4,147,000	5,167,000	5,167,000	6,125,000	6,125,000	6,034,000	5,204,000	5,100,000	4,546,000	5,172,000	4,936,000	5,136,000	5,136,000	5,980,000	5,523,000	7,199,000
short-term portion of equipment financing lines																																																									152,000	310,000	489,000	690,000	1,028,000	1,268,000	1,453,000	1,725,000	1,797,000	1,925,000	2,460,000	3,029,000	3,542,000	4,050,000	4,171,000	4,117,000	4,039,000	3,691,000	3,317,000	2,990,000	2,763,000	2,726,000	2,608,000	2,448,000	2,421,000	2,387,000	2,108,000	1,992,000
series a convertible preferred stock — zero shares at december 31, 2012 and 8,070 shares at december 31, 2011
series b convertible preferred stock — 23,026 shares at december 31, 2012 and zero shares at december 31, 2011
issued and outstanding: 142,457,469 shares at december 31, 2012 and 74,915,739 shares at december 31, 2011																																																					143,000
short-term portion of deferred revenue																																																						129,000										708,000		12,297,000	12,234,000	12,234,000	12,234,000	12,234,000				12,234,000				1,400,000	2,100,000	2,800,000	4,299,000	2,800,000	2,800,000	2,800,000
commitments and contingencies stockholders’ equity:
series a convertible preferred stock — zero shares at september 30, 2012 and 8,070 shares at december 31, 2011;
series b convertible preferred stock — 23,026 shares at september 30, 2012 and zero shares at december 31, 2011
authorized: 245,000,000 shares; issued and outstanding: 142,413,069 shares at september 30, 2012 and 74,915,739 shares at december 31, 2011
series a convertible preferred stock — 8,070 shares at june 30, 2012 and december 31, 2011;
series b convertible preferred stock — 23,026 shares at june 30, 2012 and zero shares at december 31, 2011
authorized: 245,000,000 shares; issued and outstanding: 133,478,796 shares at june 30, 2012 and 74,915,739 shares at december 31, 2011
authorized: 10,000,000 shares issued and outstanding: series a convertible preferred stock — 8,070 shares at march 31, 2012 and december 31, 2011
authorized: 245,000,000 shares issued and outstanding: 77,512,080 shares at march 31, 2012 and 74,915,739 shares at december 31, 2011																																																								78,000
long-term portion of equipment financing lines																																																												34,000	309,000	489,000	724,000	1,338,000	1,757,000	2,187,000	3,081,000	3,576,000	4,112,000	4,639,000	5,541,000	6,604,000	7,654,000	7,144,000	6,654,000	6,136,000	5,933,000	6,636,000	6,914,000	6,868,000	7,490,000	8,106,000	8,210,000	7,599,000
authorized: 10,000,000 shares in 2011 and 2010
issued and outstanding: series a convertible preferred stock — 8,070 shares in 2011 and zero shares in 2010
authorized: 245,000,000 shares in 2011 and 170,000,000 in 2010
issued and outstanding: 74,915,739 shares in 2011 and 66,907,600 shares in 2010																																																									75,000
authorized: 10,000,000 shares at september 30, 2011 and december 31, 2010
issued and outstanding: series a convertible preferred stock — 8,070 shares at september 30, 2011 and zero shares at december 31, 2010
authorized: 245,000,000 shares at september 30, 2011 and 170,000,000 shares at december 31, 2010
issued and outstanding: 72,279,751 shares at september 30, 2011 and 66,907,600 shares at december 31, 2010																																																										72,000
authorized: 10,000,000 shares at june 30, 2011 and december 31, 2010
issued and outstanding: series a convertible preferred stock — 8,070 shares at june 30, 2011 and zero shares at december 31, 2010
authorized: 170,000,000 shares at june 30, 2011 and december 31, 2010
issued and outstanding: 72,279,751 shares at june 30, 2011 and 66,907,600 shares at december 31, 2010																																																											72,000
convertible preferred stock:
authorized: 10,000,000 shares at march 31, 2011 and december 31, 2010 issued and outstanding: zero shares at march 31, 2011 and december 31, 2010
authorized: 170,000,000 shares at march 31, 2011 and december 31, 2010 issued and outstanding: 66,916,100 shares at march 31, 2011 and 66,907,600 shares at december 31, 2010																																																												67,000
investments in auction rate securities																																																														6,698,000	15,311,000	15,782,000	17,254,000	17,306,000
investment put option related to auction rate securities rights																																																														777,000	2,339,000	2,368,000	2,721,000
related party notes receivable																																																															9,000															451,000			350,000	387,000	1,146,000	1,146,000
loan with ubs																																																															9,873,000	10,470,000	12,287,000	12,355,000
authorized: 170,000,000 shares; issued and outstanding: 64,572,009 shares at september 30, 2010 and 61,275,036 shares at december 31, 2009																																																													65,000
authorized: 170,000,000 shares; issued and outstanding: 64,513,092 shares at june 30, 2010 and 61,275,036 shares at december 31, 2009																																																														64,000
authorized: 170,000,000 shares; issued and outstanding: 62,479,802 shares at march 31, 2010 and 61,275,036 shares at december 31, 2009																																																															62,000
related party notes receivable — short-term portion																																																																9,000	40,000	40,000	77,000	77,000	177,000	127,000	127,000	127,000	226,000	160,000	160,000	160,000	151,000	151,000	339,000	398,000	650,000	713,000
assets held-for-sale																																																																178,000	178,000	283,000	294,000
related party notes receivable — long-term portion																																																																		9,000	9,000	39,000	49,000	99,000	186,000	216,000	226,000	292,000	412,000	442,000	451,000
long-term portion of deferred revenue																																																																		9,122,000	15,191,000	18,250,000	21,308,000	24,367,000	27,425,000	30,483,000	33,542,000	29,666,000							700,000	1,400,000	2,800,000	3,500,000
authorized: 170,000,000 shares; issued and outstanding: 60,908,591 shares at september 30, 2009 and 49,939,069 shares at december 31, 2008																																																																61,000
authorized: 170,000,000 shares; issued and outstanding: 60,790,925 shares at june 30, 2009 and 49,939,069 shares at december 31, 2008																																																																	61,000
investment in put option																																																																		2,719,000
authorized: 170,000,000 shares; issued and outstanding:
53,560,417 shares at march 31, 2009 and 49,939,069 shares at december 31, 2008																																																																		54,000
deferred stock-based compensation																																																																			-62,000	-124,000	-187,000	-329,000	-476,000	-627,000	-786,000	-1,094,000	-1,410,000	-1,752,000	-2,073,000	-2,452,000	-2,786,000	-3,186,000	-3,552,000	-4,251,000	-5,249,000	-4,993,000
authorized: 120,000,000 shares
issued and outstanding: 49,282,362 shares in 2007 and 43,283,558 shares in 2006																																																																						49,000
commitments
issued and outstanding: 43,283,558 shares in 2006 and 29,710,895 shares in 2005																																																																										43,000
convertible preferred stock, 0.001 par value:
authorized: 120,000,000 shares; issued and outstanding: 37,793,573 shares in 2006 and 29,710,895 shares in 2005																																																																											38,000
authorized: 120,000,000 shares; issued and outstanding: 36,613,565 shares in 2006 and 29,710,895 shares in 2005																																																																												37,000
authorized: 120,000,000 shares; issued and outstanding: 35,595,682 shares in 2006 and 29,710,895 shares in 2005																																																																													36,000
liabilities, convertible preferred stock and stockholders’ equity
authorized: 10,000,000 shares
issued and outstanding: none in 2005 and 2004
issued and outstanding: 29,710,895 shares in 2005 and 28,453,173 shares in 2004																																																																														30,000
total liabilities, convertible preferred stock and stockholders’ equity																																																																														91,461,000					149,503,000
related party notes receivable— long-term portion																																																																															572,000	602,000
related party accrued liabilities																																																																															408,000	461,000	345,000	96,000	716,000
authorized: 120,000,000 shares; issued and outstanding: 28,660,743 shares in 2005 and 28,453,173 shares in 2004																																																																															29,000
authorized: 120,000,000 shares; issued and outstanding: 28,621,634 shares in 2005 and 28,453,173 shares in 2004																																																																																29,000
authorized: 120,000,000 shares; issued and outstanding: 28,509,600 shares in 2005 and 28,453,173 shares in 2004																																																																																	29,000
related party receivable																																																																																			185,000
prepaids and other current assets																																																																																			2,660,000	3,070,000
convertible preferred stock, 0.001 par value
authorized: 37,300,000 shares
issued and outstanding: none in 2004 and 34,128,308 shares in 2003
authorized: 61,500,000 shares
issued and outstanding: 28,332,339 shares in 2004 and 2,307,258 shares in 2003																																																																																			28,000
liabilities, convertible preferred stock and stockholders’ deficit
issued and outstanding: 34,128,308 shares in 2004 and in 2003
stockholders’ deficit
issued and outstanding: 2,623,199 shares in 2004 and 2,307,258 shares in 2003																																																																																				3,000
total liabilities, convertible preferred stock and stockholders’ deficit																																																																																				56,169,000

Cashflow Statements:

Quarterly

Annual

Unit: USD	2025-12-31	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-12-31	2014-09-30	2014-06-30	2014-03-31	2013-12-31	2013-08-05	2012-08-05	2011-08-05	2010-08-05	2008-08-05	2008-03-31	2007-12-31	2007-08-05	2007-06-30	2007-03-31	2006-12-31	2006-06-30	2006-03-31	2005-12-31	2005-08-05	2005-06-30	2005-03-31	2004-12-31	2004-08-05	2004-06-30	2004-03-31

cash flows from operating activities:
net loss	-183,031,000	-306,178,000	-134,370,000	-161,376,000	-150,020,000	-160,545,000	-143,318,000	-135,643,000	-136,896,000	-129,422,000	-128,637,000	-131,289,000	-137,380,000	-142,310,000	-19,820,000	-89,445,000	-30,570,000	-76,086,000	-61,554,000	-47,104,000	-43,930,000	-3,175,000	-40,780,000	-39,405,000	-30,640,000	-29,573,000	-32,113,000	-29,366,000	-26,468,000	-22,017,000	-27,523,000	-30,281,000			-29,081,000	-25,867,000			-11,611,000	-12,455,000	-9,229,000	-8,849,000	-10,551,000	-8,872,000	8,443,000										-13,895,000	-13,252,000		-12,629,000	-11,692,000	-15,946,000	-13,785,000	-12,464,000	-11,081,000		-10,540,000	-10,530,000	-11,820,000		-9,231,000	-5,932,000
adjustments to reconcile net loss to net cash from operating activities:
non-cash interest expense on liabilities related to revenue participation right purchase agreement
stock-based compensation expense	30,506,000	30,696,000	27,535,000	23,549,000	26,250,000	25,356,000	24,622,000	21,612,000	19,487,000	18,716,000	18,668,000	15,194,000	13,498,000	13,175,000
non-cash lease expense	1,610,000	1,472,000	1,336,000	1,230,000	1,162,000	1,103,000	1,054,000	995,000	942,000	937,000	936,000	935,000	1,083,000	680,000	595,000	227,000	1,954,000
loss on disposition of property and equipment
depreciation of property and equipment	2,861,000	2,679,000	2,285,000	2,300,000	2,383,000	2,411,000	2,406,000	2,331,000	6,335,000	1,854,000	1,855,000	1,848,000	1,658,000													336,000	280,000	286,000		268,000	618,000	673,000
change in fair value of derivative liabilities	-900,000	-700,000	-3,000,000	400,000	-1,200,000	-700,000
change in fair value of liabilities related to rpi transactions	-13,300,000	2,800,000	14,600,000	-3,900,000	4,600,000	15,200,000
realized gain on investment	-8,000	-1,000
interest receivable and amortization on investments	-3,075,000	-2,696,000	-4,032,000	-6,174,000	-7,701,000	-11,091,000	-8,499,000	-5,224,000	-5,101,000	-3,736,000	-3,861,000	-3,037,000	-4,218,000	-2,038,000	542,000	1,004,000	1,454,000	1,424,000	1,083,000	933,000	-792,000	-429,000	-266,000	293,000	-1,004,000	-375,000	-675,000	-533,000	-440,000	-737,000	-596,000	96,000
non-cash interest expense related to debt	8,470,000	5,648,000	5,330,000	3,453,000	3,532,000	3,486,000	2,662,000	1,879,000	-13,609,000	7,079,000	6,983,000	6,888,000	1,088,000	1,967,000	1,342,000	1,300,000	1,875,000	1,825,000	1,749,000	1,676,000	1,691,000	1,648,000	1,577,000	1,724,000	112,000	291,000	333,000	183,000
debt conversion expense	0
changes in operating assets and liabilities:
accounts receivable	-15,956,000	6,602,000	-6,398,000	14,638,000	-16,406,000	-244,000	834,000	449,000	1,216,000	-1,514,000	21,000	-859,000	2,147,000	-321,000	4,083,000	50,763,000	-51,175,000	2,057,000	1,813,000	-94,000	545,000	-2,711,000	450,000	2,459,000	1,413,000	2,417,000	-4,828,000	-1,934,000	6,925,000	-8,920,000	-199,000	1,075,000	8,888,000	-10,000,000																																		-1,000	-13,000	74,000
prepaid and other assets	-4,197,000	6,277,000	-4,637,000	-376,000	-8,444,000	4,475,000	8,161,000	-6,630,000	8,533,000	342,000	-5,652,000	-1,627,000	1,528,000	-909,000	-6,611,000	-1,422,000	3,863,000	-5,663,000	-8,258,000	2,677,000			-1,109,000	949,000	-2,117,000	-1,479,000	717,000	-983,000	-209,000	-162,000	782,000	1,406,000	147,000	355,000	-1,424,000	-1,239,000	215,000	3,678,000	-3,558,000	-1,042,000	830,000	-211,000	-299,000	-716,000	547,000	205,000	-418,000	-60,000	74,000	684,000	45,000	-1,400,000	394,000	-642,000	291,000	-91,000	121,000	-626,000	121,000	701,000	-727,000	438,000	-159,000	780,000	-198,000	142,000
accounts payable	-309,000	6,598,000	950,000	-4,576,000	5,905,000	1,717,000	-1,811,000	-10,294,000	7,711,000	1,235,000	-4,323,000	-8,106,000	13,048,000	3,406,000	-8,850,000	-3,080,000	3,857,000	-422,000	1,667,000	-4,047,000	1,312,000	3,818,000	-607,000	-4,633,000	4,748,000	-1,782,000	2,647,000	-1,217,000	1,740,000	688,000	-1,087,000	-2,831,000	-5,000	3,350,000	-1,162,000	-726,000	3,032,000	-2,175,000	2,303,000	-1,462,000	139,000	305,000	216,000	95,000	-315,000	657,000	-407,000	-2,113,000	1,759,000	-800,000	-257,000	-143,000	102,000	-586,000	970,000	-1,087,000	-490,000	443,000	-490,000	114,000	753,000	-332,000	171,000	668,000	-517,000	-513,000		-523,000	684,000	-557,000
deferred revenue	0	268,000											0	0															7,252,000	-4,165,000	-7,841,000	-1,731,000	-870,000	2,434,000	-2,966,000	2,915,000	-3,073,000	11,299,000	-1,929,000	-4,095,000	-4,854,000	-3,574,000	-2,867,000	-1,447,000	28,264,000	-3,648,000	-2,184,000	-5,033,000	-19,817,000			797,000	-534,000	-3,059,000	-3,058,000	-3,058,000	3,876,000	-3,059,000	3,876,000	41,900,000	-700,000	-700,000	-700,000	-700,000	-2,199,000	799,000		-700,000	-700,000	-700,000
accrued and other liabilities	26,368,000	7,617,000	13,985,000	-14,367,000	10,077,000	5,511,000	4,173,000	-5,579,000	32,129,000	4,155,000	-11,426,000	-7,755,000	-351,000	8,638,000	6,079,000	-3,522,000	1,239,000	10,787,000	6,154,000	-3,120,000	1,472,000	4,191,000	2,518,000	-1,064,000	-265,000	1,320,000	-757,000	-2,466,000	46,000	-512,000	-2,664,000	1,067,000	898,000	3,780,000	-4,063,000	151,000	-177,000	7,979,000	1,508,000	-365,000	1,654,000	759,000	2,000,000	-1,418,000	-636,000	-904,000	-765,000	-560,000	-1,639,000	-103,000	404,000
operating lease liabilities	-4,223,000	-2,150,000	-2,323,000	-2,143,000	-2,025,000	-1,815,000	-1,692,000	-1,712,000	-1,134,000	-78,000	-74,000	-120,000	671,000	1,114,000	522,000	-579,000	10,006,000			9,816,000	-1,235,000	-1,206,000	-1,139,000	-1,112,000	-1,022,000	-1,000,000	-938,000	-916,000
other non-current liabilities	-3,528,000	-2,681,000	-1,662,000	1,621,000	237,000	240,000	102,000	-1,935,000	-3,576,000	-2,659,000	-2,645,000	-705,000	-203,000	-197,000	-1,990,000	-1,668,000	-1,826,000
net cash from operating activities	-142,651,000	-107,505,000	-128,236,000	-131,617,000	-65,570,000	-101,500,000	-99,313,000	-129,507,000	-74,037,000	-96,205,000	-121,805,000	-122,286,000	-98,190,000	-84,040,000	-90,475,000	-26,811,000	-44,737,000	-38,770,000	-29,496,000	-29,519,000	52,150,000	14,367,000	-27,439,000	-30,135,000	-19,055,000	-20,268,000	-24,677,000	-26,907,000	-12,327,000	-32,235,000	-26,846,000	-29,807,000	-24,071,000	-25,483,000	-31,261,000	-20,944,000	77,829,000	-12,122,000	-11,218,000	-17,507,000	-9,942,000	-10,347,000	-9,187,000	34,359,000	-8,130,000	-9,515,000	-9,376,000	-17,822,000	-12,429,000	-12,222,000	-8,737,000	-13,178,000	-12,208,000	-17,856,000	-13,822,000	-14,038,000	34,729,000	-13,449,000	34,729,000	-13,172,000	-11,347,000	-10,989,000	-10,091,000	-8,747,000	-12,045,000	-8,601,000		-8,653,000	-7,278,000	-7,020,000
capital expenditures	-5,082,000	-10,096,000	-2,809,000	-4,170,000	1,593,000	-307,000	-1,686,000		-77,000	-220,000	-717,000	71,000	-4,450,000	-9,386,000	2,235,000	887,000	-16,746,000	-13,984,000	-3,297,000	-2,863,000	-6,555,000	-2,592,000	-864,000	-1,041,000	-1,306,000	-1,006,000	-50,000	-257,000	-210,000	-358,000	-60,000	-261,000	-780,000	-451,000	-258,000	-1,388,000	-854,000	-306,000	-16,000	-420,000	-204,000	-53,000	-175,000	-130,000	-247,000	-100,000	-424,000	-333,000	-252,000	-177,000	-13,000	-163,000	-154,000	-188,000	-379,000	-396,000	-1,655,000	-292,000	-1,655,000	-1,635,000	-973,000	-925,000	-206,000	-412,000	-374,000	-473,000		-780,000	-204,000	-128,000
free cash flows	-147,733,000	-117,601,000	-131,045,000	-135,787,000	-63,977,000	-101,807,000	-100,999,000		-74,114,000	-96,425,000	-122,522,000	-122,215,000	-102,640,000	-93,426,000	-88,240,000	-25,924,000	-61,483,000	-52,754,000	-32,793,000	-32,382,000	45,595,000	11,775,000	-28,303,000	-31,176,000	-20,361,000	-21,274,000	-24,727,000	-27,164,000	-12,537,000	-32,593,000	-26,906,000	-30,068,000	-24,851,000	-25,934,000	-31,519,000	-22,332,000	76,975,000	-12,428,000	-11,234,000	-17,927,000	-10,146,000	-10,400,000	-9,362,000	34,229,000	-8,377,000	-9,615,000	-9,800,000	-18,155,000	-12,681,000	-12,399,000	-8,750,000	-13,341,000	-12,362,000	-18,044,000	-14,201,000	-14,434,000	33,074,000	-13,741,000	33,074,000	-14,807,000	-12,320,000	-11,914,000	-10,297,000	-9,159,000	-12,419,000	-9,074,000		-9,433,000	-7,482,000	-7,148,000
cash flows from investing activities:
purchases of investments	-345,650,000	-335,452,000	-222,966,000	-159,105,000	-121,125,000	-214,401,000	-815,235,000	-142,655,000	-226,115,000	-117,725,000	-201,592,000	-89,779,000	-125,179,000	-467,177,000	-69,910,000	-193,127,000	-31,592,000	-321,589,000	-105,661,000	-66,200,000	-269,278,000	-138,681,000	-17,274,000	-10,592,000	-136,085,000	-41,637,000	-58,866,000	-41,295,000	-51,796,000	-56,220,000	-107,984,000	-24,224,000	-25,956,000	-12,926,000	-68,761,000	-132,770,000	-65,189,000	-9,260,000	-20,563,000	-50,146,000	-20,908,000	-29,003,000	-15,815,000	-49,840,000	-13,799,000	-5,557,000	-32,217,000	-55,470,000	-11,148,000	-7,761,000	-10,747,000	11,255,000	-36,393,000	0	-9,400,000	-6,400,000	-26,400,000	-13,400,000	-26,400,000	-56,171,000	-35,098,000	-35,800,000	-32,650,000	-25,758,000	-16,618,000	-14,300,000
investment in non-marketable equity security	0	0	0	-5,000,000
maturities of investments	280,094,000			275,725,000	233,278,000	170,049,000	165,602,000	175,296,000	144,783,000	190,984,000	284,437,000	250,701,000	157,633,000	181,136,000	136,035,000	129,790,000	96,681,000	128,572,000	133,334,000	64,250,000	99,154,000	40,250,000
sales of investments	8,000	1,000							-2,000	0	0	4,977,000					0	0	0	3,300,000
purchases of property and equipment	-5,644,000	-9,354,000	-4,145,000	-5,664,000	-1,290,000	-701,000			-77,000	-220,000	-717,000	-402,000	-3,205,000	-6,331,000	-857,000	-942,000	-17,754,000	-15,700,000	-8,792,000	-6,626,000	-6,555,000	-2,592,000	-864,000	-1,041,000	-1,306,000	-1,006,000	-50,000	-257,000	-210,000	-358,000	-60,000	-261,000	-780,000	-451,000	-258,000	-1,388,000	-854,000	-306,000	-16,000	-420,000	-204,000	-53,000	-175,000	-130,000	-247,000	-100,000	-424,000	-333,000	-252,000	-177,000	-13,000	-163,000	-154,000	-188,000	-379,000	-396,000	-1,655,000	-292,000	-1,655,000	-1,635,000	-973,000	-925,000	-206,000	-412,000	-374,000	-473,000	-288,000	-780,000	-204,000	-128,000
net cash from investing activities	-71,192,000	-70,979,000	52,881,000	105,956,000	110,863,000	-45,053,000	-651,548,000	32,641,000	-81,411,000	73,039,000	82,128,000	165,497,000	29,249,000	-292,372,000	65,268,000	-64,279,000	47,335,000	-208,717,000	18,881,000	-5,276,000	-173,618,000	-101,023,000	34,637,000	43,489,000	-105,266,000	13,682,000	-2,767,000	19,644,000	26,508,000	2,677,000			30,763,000	39,658,000	-23,949,000	-112,300,000	-41,970,000	13,971,000	-3,916,000	-20,161,000	25,411,000	11,306,000	11,439,000	-32,093,000	6,304,000	10,067,000	8,440,000	-28,860,000	5,813,000	10,470,000	5,052,000	7,539,000	4,704,000	-83,000	3,812,000	20,866,000	2,931,000	21,050,000	2,931,000	-32,161,000	-18,583,000	34,262,000	5,923,000	9,378,000	8,330,000	10,861,000		11,256,000	-85,774,000	5,217,000
cash flows from financing activities:
repayment of finance lease liabilities	0	0	-2,000	-202,000	-243,000	-236,000	-233,000	-227,000	-222,000	-217,000	-212,000	-207,000	-105,000	-424,000	-267,000	-148,000
repayment of term loans	-2,722,000	-2,709,000	-2,696,000	-2,682,000	-2,671,000	-2,658,000
repayment of convertible debt	0												0
proceeds from issuance of convertible debt	0												0
proceeds from draw on rpi multi tranche loan
proceeds from issuance of common stock related to at-the-market offering, net of issuance costs					0	0	0	93,640,000	162,921,000
proceeds from issuance of common stock related to public offering, net of issuance costs					0	0
proceeds from issuance of common stock related to private placement, net of issuance costs					0	0
proceeds from issuance of common stock under equity incentive and stock purchase plans	14,648,000	6,935,000	6,745,000	7,651,000	6,480,000	6,319,000	10,685,000	29,532,000	6,101,000	3,124,000	5,687,000	3,547,000
taxes paid related to net share settlement of equity awards	-1,221,000	-720,000	-514,000	-13,000	-1,182,000	0	0	-18,449,000	0	0	0	-10,517,000
net cash from financing activities	110,705,000	330,466,000	78,533,000	4,754,000	2,384,000	3,425,000	821,011,000	103,791,000	168,800,000	54,219,000	5,475,000	-7,177,000	29,885,000	389,019,000	3,416,000	93,846,000	19,506,000	300,895,000	3,175,000	-3,596,000	3,641,000	226,334,000	4,160,000	-11,000	121,120,000	11,859,000	22,396,000	4,416,000	451,000	10,227,000	2,978,000	-524,000	2,194,000	1,434,000	106,557,000	115,734,000	715,000	727,000	589,000	14,861,000	23,645,000	164,000	41,000	65,000	9,134,000	0	35,000	39,780,000	7,516,000	5,000	2,667,000	16,740,000	2,658,000	-740,000	-1,014,000	1,245,000	27,001,000	-426,000	27,001,000	36,506,000	6,585,000	36,323,000	5,880,000	262,000	-191,000	-505,000		-478,000	101,786,000	-272,000
effect of exchange rate changes								27,000
net increase in cash, cash equivalents, and restricted cash	-102,947,000	152,028,000	2,496,000	-21,177,000	47,969,000	-143,254,000	70,166,000	6,952,000	13,332,000	31,053,000	-34,202,000	36,034,000
cash, cash equivalents, and restricted cash, beginning of period	0	0	0	95,232,000	0	0	0	113,399,000	0	0	0	67,182,000
cash, cash equivalents, and restricted cash, end of period	-102,947,000	152,028,000	2,496,000	74,055,000	47,969,000	-143,254,000	70,166,000	120,351,000	13,332,000	31,053,000	-34,202,000	103,216,000
supplemental cash flow disclosures:
cash paid for interest	3,040,000	9,621,000	606,000	9,647,000	636,000	14,456,000	672,000	10,206,000	317,000	31,000	9,907,000	40,000	9,610,000	81,000	2,760,000	2,714,000																																																				112,000	104,000	107,000
non-cash investing and financing activities:
right-of-use assets recognized in exchange for operating lease obligations	-172,000	2,926,000	0	3,501,000	-28,000	198,000	133,000	178,000					8,592,000
amounts unpaid for purchases of property and equipment	562,000	-742,000	1,336,000	1,494,000	2,883,000	394,000	-1,686,000	1,754,000				473,000	-1,245,000	-3,055,000	3,092,000	1,829,000	1,008,000	1,716,000	5,495,000	3,763,000
issuance of common stock in connection with repurchase of convertible note	0												0
non-cash interest expense on liabilities related to revenue participation right purchase agreements		14,995,000	13,207,000	14,104,000		13,396,000	11,593,000	10,244,000		6,886,000	6,349,000	6,313,000		8,994,000	7,031,000	6,592,000
proceeds from rpi transactions		0			0	0
effect of exchange rate changes on cash		46,000	-682,000	-270,000		-126,000
maturities and paydown of investments
loss on extinguishment of debt													0	0	0	2,693,000
loss on inducement of convertible debt													0
debt extinguishment costs													0	0	0	-2,409,000
cash settlement of capped call options associated with 2026 notes
right-of-use assets recognized in exchange for finance lease obligations													0	0	352,000	703,000
repayment of term loan								-705,000					0	0	0	-47,651,000
impairment of right-of-use assets
proceeds from public offerings of common stock, net of discounts, commissions and offering cost																	0				0
proceeds from private placement																					0
proceeds from 2022 rpi transactions									0
loss on investments										0	1,000	34,000
loss on investment
claims settlement under section 16																					0	0	0	2,151,000
net increase in cash, cash equivalents, and restricted cash equivalents
cash, cash equivalents, and restricted cash equivalents, beginning of period
cash, cash equivalents, and restricted cash equivalents, end of period
proceeds from 2020 rpi transactions														0	0	149,581,000
proceeds from and payments for stock-based award activities														6,187,000	3,683,000	-5,527,000		3,990,000
net increase in cash and cash equivalents																2,756,000	22,104,000	53,408,000	-7,440,000	-38,391,000	-117,827,000	139,678,000	11,358,000	13,343,000					14,632,000	-19,331,000			8,886,000	15,609,000			36,574,000	2,576,000	-14,545,000	-22,807,000	39,114,000	1,123,000	2,293,000	2,331,000	7,308,000	552,000			900,000	-1,747,000	-1,018,000	11,101,000	-4,846,000	-18,679,000	-11,024,000	8,073,000	64,661,000	7,175,000	64,661,000	-8,827,000	-23,345,000	59,596,000	1,712,000	893,000	-3,906,000	1,755,000
cash and cash equivalents, beginning of period														0	0	112,666,000	0	0	0	82,985,000	0	0	0	36,433,000	0	0	0	42,256,000	0	0	0	125,206,000	0	0	0	66,874,000	0	0	0	65,076,000	0	0	0	20,215,000	0	0	0	20,158,000	0	14,907,000	18,833,000	-8,047,000	25,561,000	0	116,564,000	0	39,387,000	0	39,387,000	0	0	13,515,000	0	0	0	13,061,000	-713,000	0	0	10,991,000
cash and cash equivalents, end of period														12,607,000	-21,791,000	115,422,000	22,104,000	53,408,000	-7,440,000	44,594,000	-117,827,000	139,678,000	11,358,000	49,776,000	-3,201,000	5,273,000	-5,048,000	39,409,000	14,632,000	-19,331,000	-68,056,000	115,011,000	8,886,000	15,609,000	51,347,000	49,364,000	36,574,000	2,576,000	-14,545,000	42,269,000	39,114,000	1,123,000	2,293,000	22,546,000	7,308,000	552,000	-901,000	13,256,000	900,000	13,160,000	17,815,000	3,054,000	20,715,000	-18,679,000	105,540,000	8,073,000	104,048,000	7,175,000	104,048,000	-8,827,000	-23,345,000	73,111,000	1,712,000	893,000	-3,906,000	14,816,000	-6,714,000	2,125,000	8,734,000	8,916,000
depreciation and amortization of property and equipment															1,407,000	1,341,000	734,000	462,000	543,000	537,000	471,000	536,000	416,000	408,000											439,000	421,000	224,000	177,000	170,000	170,000	151,000	146,000	147,000	145,000	137,000	126,000	122,000	105,000	88,000	124,000	178,000	324,000	489,000	635,000	639,000	659,000	755,000	745,000	755,000	706,000	744,000	751,000	743,000	760,000	771,000	788,000
net decrease in cash and cash equivalents																									-3,201,000	5,273,000	-5,048,000	-2,847,000				-10,195,000				-17,510,000												-6,902,000
non-cash stock-based compensation expense																8,985,000	6,711,000	7,767,000	7,093,000	5,261,000	4,877,000	4,692,000	4,527,000	3,524,000
gain on investment
contract assets																									0	575,000	1,897,000	2,082,000	-8,383,000	4,499,000	5,826,000	3,212,000
proceeds from stock-based award activities																				-3,596,000	2,132,000
net proceeds from long-term debt, net of debt discount and issuance costs
net proceeds from convertible notes, net of debt discount and issuance costs
issuance of common stock under at-the-market offering, net of issuance costs
purchase of capped call options associated with convertible notes
non-cash interest expense on liability related to sale of future royalties																		2,985,000	2,900,000	2,822,000	5,673,000	5,481,000	5,932,000	5,706,000	5,533,000	5,321,000	5,064,000	4,819,000	4,741,000	4,559,000	4,338,000	4,129,000	4,074,000	3,918,000	3,729,000	2,307,000
right-of-use assets recognized in exchange for lease obligations																		0	5,321,000	77,887,000	0	0	0	1,106,000	0	0
operating lease right-of-use assets																			2,002,000	1,124,000			1,042,000	1,016,000	921,000	898,000	877,000	856,000
operating lease and other non-current liabilities
prepaid and other current assets																					-2,477,000
operating lease right-of-use assets and other assets																					-1,884,000
contract liabilities																													0	-8,132,000	-1,416,000	-9,202,000
sales of property and equipment
proceeds from issuance under employee stock purchase plan
net proceeds from long-term debt, net of debt discount and issuance cost																										0
proceeds from stock based award activities																										459,000
sales and maturities of investments																								55,122,000	32,125,000	56,325,000	56,149,000	61,196,000	78,500,000	59,255,000	63,856,000	44,621,000
proceeds from and payments for stock based award activities																								-2,162,000
issuance of common stock under at the market offering, net of issuance costs																									0	11,400,000
issuance of warrants in connection with long-term debt																									0	0
non-cash equity-related expense																										2,783,000	2,819,000	2,282,000		2,572,000	2,505,000	2,403,000
supplemental cash flow disclosure - non-cash investing and financing activity:
public offerings of common stock, net of issuance costs																												5,117,000
proceeds from common stock award exercise																												31,000
issuance of equity for stock-based awards and warrants																												-732,000		329,000	2,978,000	-524,000
right-of-use assets obtained in exchange for lease obligations																												10,686,000
stock-based compensation																																		2,447,000	2,219,000	1,922,000	1,880,000	1,866,000	1,789,000	1,611,000	1,348,000	1,121,000	1,202,000	896,000	886,000	891,000	859,000	694,000	656,000	966,000	943,000	498,000	994,000	1,346,000	1,527,000	1,391,000	1,160,000	1,476,000	1,160,000	1,077,000	1,417,000	938,000	336,000	343,000	346,000	402,000	419,000	553,000	515,000	389,000
net gain on disposal of equipment
non-cash interest expense related to long-term debt																															411,000	177,000	217,000	140,000	139,000	139,000
proceeds from public offerings of common stock, net of issuance costs																																	0	-8,000	94,877,000	17,355,000									9,102,000	0	0	39,869,000
proceeds from sale of future royalties, net of issuance costs																																	0	0	0	90,621,000
proceeds from issuance of common stock related to sale of future royalties, net of issuance costs																																	0	0	0	7,560,000
proceeds from stock based award activities and warrants																																	933,000	1,442,000	11,680,000	198,000	715,000	727,000	589,000	-135,000		164,000	41,000	65,000
supplemental disclosure of cash flow information
cash paid for taxes
loss on disposal of equipment
sale of future royalties, net of issuance costs
issuance of common stock related to sale of future royalties, net of issuance costs
issuance of long term debt, net of debt discount and issuance costs
net cash from in investing activities																																20,136,000
net income																																	-40,485,000				8,632,000										-8,374,000	-8,744,000	6,531,000	-12,619,000	-9,928,000	-13,155,000	-12,189,000				-11,692,000
adjustments to reconcile net income to net cash from (used in) operating activities:
non-cash stock-based compensation
gain on sale of investments																																									-2,000				0	0
net proceeds from long term debt, net of debt discount and issuance costs
adjustments to reconcile net income to net cash from operating activities:
proceeds from sales and maturities of investments																																		53,035,000	45,070,000	21,858,000	24,073,000	23,536,000	16,631,000	30,405,000	46,522,000	40,362,000	27,429,000	17,877,000	20,350,000	15,724,000	41,081,000	26,943,000	17,203,000	18,408,000	15,667,000	-3,464,000	40,810,000	5,000	12,571,000	27,662,000	31,077,000	34,643,000	31,077,000	26,442,000	18,062,000	70,361,000	38,744,000	35,239,000	25,322,000	24,690,000	31,837,000	43,775,000	43,273,000	5,345,000
proceeds from sale of property and equipment																																						1,000																						0			0
proceeds from long term debt, net of debt discount and issuance costs																																					0	0	0	14,996,000
gain on disposal of equipment																																			0	-82,000
related party accounts receivable																																				-885,000	66,976,000	-66,974,000	-26,000	12,000	36,000	-43,000	965,000	45,676,000				-2,111,000		-324,000	-69,000	-150,000	169,000	-4,000	29,000	27,000	41,938,000	68,000	41,938,000	-42,026,000	-23,000	526,000	387,000	-774,000	-79,000	-78,000				-15,000
non-cash interest expense																																					139,000	138,000	138,000	119,000														23,000	23,000	23,000	23,000	23,000	23,000	23,000	23,000	23,000	23,000	23,000	23,000	23,000	23,000	23,000	23,000	23,000
proceeds from sales of property and equipment																																																	10,000
loss on disposal of property and equipment																																																									3,000	1,000	3,000
gain on disposal of property and equipment
amortization of debt discount
related party payables and accrued liabilities																																																	0	-150,000	-12,000	1,000	10,000			-14,000	-49,000	-39,000	-49,000	-52,000	-122,000	-259,000
payments from stock based award activities and warrants																																													32,000
non-cash restructuring expenses, net of reversals																																																			-41,000
decrease in restricted cash																																																							1,020,000	0		0	-91,000	-830,000	-554,000	626,000	-236,000		0	844,000
proceeds from draw down of committed equity financing facilities and at-the-market facility, net of commission and issuance costs																																																			2,819,000
proceeds from issuance of preferred stock, net of issuance costs
repayment of equipment financing lines																																																			-152,000	-72,000	-424,000	-1,049,000	-1,036,000	-1,023,000	-885,000	-971,000	-885,000	-794,000	-678,000	-666,000	-632,000	-602,000	-595,000	-581,000
accounts receivable and related party accounts receivable																																														-871,000
license fee receivable
proceeds (payments) from stock based award activities and warrants
proceeds (payments) from stock based award activities, and warrants																																																-89,000
(gain) loss on disposal of equipment
proceeds from initial public offering, sale of common stock to related party, and public offerings, net of issuance costs																																																	0
proceeds from other issuances of common stock and warrants																																																	7,516,000	5,000
non-cash impairment charges
non-cash forgiveness of loans to officers
non-cash warrant expense
other non-cash expenses																																																								0
proceeds from sales of auction rate securities
issuance of related party notes receivable
proceeds from repayments of notes receivable
repurchase of common stock																																																												0			0	-2,000	-1,000	-22,000	-2,000
proceeds from loan with ubs
repayment of loan with ubs																																																					-328,000
proceeds from equipment financing lines																																																								-1,000	1,743,000	0	1,743,000	1,659,000			472,000
non-cash forgiveness of loan to officers
tax benefit from stock-based compensation
tax expense from stock-based compensation
increase in restricted cash																																																			145,000	-92,000	441,000				-91,000
proceeds from other issuances of common stock and warrants, net of issuance costs
accrued liabilities																																																				47,000	-1,643,000	-201,000	-348,000	1,251,000	-916,000	136,000	-916,000	235,000	1,070,000	90,000	-133,000	303,000	232,000	117,000
proceeds from draw down of committed equity financing and at-the-market facility, net of issuance costs
non-cash forgiveness of loan to officer																																																								104,000				105,000
proceeds from draw down of committed equity financing facility, net of issuance costs																																																					3,370,000			1,766,000
proceeds from other issuances of common stock																																																					40,000	309,000	22,000	493,000	141,000	545,000	141,000	717,000	511,000	52,000	493,000	58,000	405,000	98,000
non-cash restructuring expenses
proceeds from initial public offering, sale of common stock to related party and public offerings, net of issuance costs
allowance for doubtful accounts
non-cash expense related to warrants issued for equipment financing lines and facility lease
proceeds from payments of related party notes receivable																																																																89,000	0	100,000
proceeds from initial public offering, net of issuance costs
proceeds from sale of common stock to related party, net of issuance costs																																																									26,009,000	0	26,009,000
proceeds from public offerings, net of issuance costs																																																									-7,000	0	-7,000
non-cash expense for acceleration of options
proceeds from payments of notes receivable
non-cash compensation expense for acceleration of options
proceeds from sale of common stock to related party
proceeds from registered direct offering, net of issuance costs																																																													0	31,993,000
proceeds from draw down of committed equity financing facility																																																													5,645,000	4,944,000
unrealized loss on investment
related party accrued liabilities																																																																-54,000	116,000	249,000
operating activities
depreciation and amortization																																																																				827,000	815,000	819,000
gain or loss on sale of property and equipment
non-cash proceeds from sale of property and equipment
related party receivable																																																																				17,000
prepaids and other current assets
other assets																																																																				-12,000	-9,000	-9,000
investing activities
investment in restricted cash																																																																				0
issuance of notes receivable
purchases of short-term and long-term investments																																																																				-31,739,000
financing activities
repayment of equipment loan																																																																				-503,000
proceeds from issuance of common stock																																																																				34,000	101,068,000	220,000
proceeds from issuance of preferred stock
additional equipment loan taken																																																																				0
increase in cash and cash equivalents																																																																				2,125,000
supplemental disclosure of cash flow information:
supplemental disclosure of significant non-cash investing and financing activities:
deferred stock-based compensation																																																																				0	688,000	1,650,000
penalty on restructuring
gain or loss on sale of fixed assets
non-cash proceeds from sale of fixed assets
non-cash expense related to warrants issued for equipment
financing lines and facility lease
prepaid expenses and other assets																																																																					387,000	-1,468,000
accruals and other liabilities																																																																					943,000	347,000
related party accruals
proceeds from sale of fixed assets
repurchase of common stock previously subject to repurchase
loss on disposal of fixed assets																																																																						9,000
proceeds from sale of equipment
repayment of equipment lines																																																																						-492,000
proceeds from equipment lines
decrease in cash and cash equivalents																																																																						-2,075,000

Cytokinetics, Incorporated(NASDAQ:CYTK)

Cytokinetics, Incorporated
(NASDAQ:CYTK)