7Baggers
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-08-05 2012-08-05 2011-08-05 2010-08-05 2008-08-05 2007-08-05 
      
    		                                                      
      cash flows from operating activities:
    		                                                      
      net income
    		-306,178,000 -134,370,000 -161,376,000 -150,020,000 -160,545,000 -143,318,000 -135,643,000 -136,896,000 -129,422,000 -128,637,000 -131,289,000 -137,380,000 -142,310,000 -19,820,000 -89,445,000 -30,570,000 -76,086,000 -61,554,000 -47,104,000 -43,930,000 -3,175,000 -40,780,000 -39,405,000 -30,640,000 -29,573,000 -32,113,000 -29,366,000 -26,468,000 -22,017,000 -27,523,000 -30,281,000 -40,485,000 -32,357,000 -29,081,000 -25,867,000 8,632,000 31,887,000 -11,611,000 -12,455,000 -9,229,000 -8,849,000 -10,551,000 -8,872,000 8,443,000 -5,971,000 -8,374,000 -8,744,000 6,531,000 -12,619,000 -9,928,000 -13,155,000 -12,189,000 -17,566,000 -11,692,000 
      adjustments to reconcile net income to net cash from operating activities:
    		                                                      
      non-cash interest expense on liabilities related to revenue participation right purchase agreements
    		14,995,000 13,207,000 14,104,000  13,396,000 11,593,000 10,244,000  6,886,000 6,349,000 6,313,000  8,994,000 7,031,000 6,592,000                                        
      stock-based compensation expense
    		30,696,000 27,535,000 23,549,000 26,250,000 25,356,000 24,622,000 21,612,000 19,487,000 18,716,000 18,668,000 15,194,000 13,498,000 13,175,000                                          
      non-cash lease expense
    		1,472,000 1,336,000 1,230,000 1,162,000 1,103,000 1,054,000 995,000 942,000 937,000 936,000 935,000 1,083,000 680,000 595,000 227,000 1,954,000                                       
      depreciation of property and equipment
    		2,679,000 2,285,000 2,300,000 2,383,000 2,411,000 2,406,000 2,331,000 6,335,000 1,854,000 1,855,000 1,848,000 1,658,000             336,000 280,000 286,000  268,000 618,000 673,000                        
      change in fair value of derivative liabilities
    		-700,000 -3,000,000 400,000 -1,200,000 -700,000                                                  
      change in fair value of liabilities related to rpi transactions
    		2,800,000 14,600,000 -3,900,000 4,600,000 15,200,000                                                  
      realized gain on investment
    		-1,000                                                      
      interest receivable and amortization on investments
    		-2,696,000 -4,032,000 -6,174,000 -7,701,000 -11,091,000 -8,499,000 -5,224,000 -5,101,000 -3,736,000 -3,861,000 -3,037,000 -4,218,000 -2,038,000 542,000 1,004,000 1,454,000 1,424,000 1,083,000 933,000 -792,000 -429,000 -266,000 293,000 -1,004,000 -375,000 -675,000 -533,000 -440,000 -737,000 -596,000 96,000                        
      non-cash interest expense related to debt
    		5,648,000 5,330,000 3,453,000 3,532,000 3,486,000 2,662,000 1,879,000 -13,609,000 7,079,000 6,983,000 6,888,000 1,088,000 1,967,000 1,342,000 1,300,000 1,875,000 1,825,000 1,749,000 1,676,000 1,691,000 1,648,000 1,577,000 1,724,000 112,000 291,000 333,000 183,000                            
      debt conversion expense
    		                                                      
      changes in operating assets and liabilities:
    		                                                      
      accounts receivable
    		6,602,000 -6,398,000 14,638,000 -16,406,000 -244,000 834,000 449,000 1,216,000 -1,514,000 21,000 -859,000 2,147,000 -321,000 4,083,000 50,763,000 -51,175,000 2,057,000 1,813,000 -94,000 545,000 -2,711,000 450,000 2,459,000 1,413,000 2,417,000 -4,828,000 -1,934,000 6,925,000 -8,920,000 -199,000 1,075,000 8,888,000 -10,000,000                      
      prepaid and other assets
    		6,277,000 -4,637,000 -376,000 -8,444,000 4,475,000 8,161,000 -6,630,000 8,533,000 342,000 -5,652,000 -1,627,000 1,528,000 -909,000 -6,611,000 -1,422,000 3,863,000 -5,663,000 -8,258,000 2,677,000   -1,109,000 949,000 -2,117,000 -1,479,000 717,000 -983,000 -209,000 -162,000 782,000 1,406,000 147,000 355,000 -1,424,000 -1,239,000 215,000 3,678,000 -3,558,000 -1,042,000 830,000 -211,000 -299,000 -716,000 547,000 205,000 -418,000 -60,000 74,000 684,000 45,000 -1,400,000 394,000 -472,000 121,000 
      accounts payable
    		6,598,000 950,000 -4,576,000 5,905,000 1,717,000 -1,811,000 -10,294,000 7,711,000 1,235,000 -4,323,000 -8,106,000 13,048,000 3,406,000 -8,850,000 -3,080,000 3,857,000 -422,000 1,667,000 -4,047,000 1,312,000 3,818,000 -607,000 -4,633,000 4,748,000 -1,782,000 2,647,000 -1,217,000 1,740,000 688,000 -1,087,000 -2,831,000 -5,000 3,350,000 -1,162,000 -726,000 3,032,000 -2,175,000 2,303,000 -1,462,000 139,000 305,000 216,000 95,000 -315,000 657,000 -407,000 -2,113,000 1,759,000 -800,000 -257,000 -143,000 102,000 874,000 -490,000 
      deferred revenue
    		268,000           0 0               7,252,000 -4,165,000 -7,841,000 -1,731,000 -870,000 2,434,000 -2,966,000 2,915,000 -3,073,000 11,299,000 -1,929,000 -4,095,000 -4,854,000 -3,574,000 -2,867,000 -1,447,000 28,264,000 -3,648,000 -2,184,000 -5,033,000 -19,817,000   797,000 -534,000 -9,993,000 3,876,000 
      accrued and other liabilities
    		7,617,000 13,985,000 -14,367,000 10,077,000 5,511,000 4,173,000 -5,579,000 32,129,000 4,155,000 -11,426,000 -7,755,000 -351,000 8,638,000 6,079,000 -3,522,000 1,239,000 10,787,000 6,154,000 -3,120,000 1,472,000 4,191,000 2,518,000 -1,064,000 -265,000 1,320,000 -757,000 -2,466,000 46,000 -512,000 -2,664,000 1,067,000 898,000 3,780,000 -4,063,000 151,000 -177,000 7,979,000 1,508,000 -365,000 1,654,000 759,000 2,000,000 -1,418,000 -636,000 -904,000 -765,000 -560,000 -1,639,000 -103,000 404,000     
      operating lease liabilities
    		-2,150,000 -2,323,000 -2,143,000 -2,025,000 -1,815,000 -1,692,000 -1,712,000 -1,134,000 -78,000 -74,000 -120,000 671,000 1,114,000 522,000 -579,000 10,006,000   9,816,000 -1,235,000 -1,206,000 -1,139,000 -1,112,000 -1,022,000 -1,000,000 -938,000 -916,000                            
      other non-current liabilities
    		-2,681,000 -1,662,000 1,621,000 237,000 240,000 102,000 -1,935,000 -3,576,000 -2,659,000 -2,645,000 -705,000 -203,000 -197,000 -1,990,000 -1,668,000 -1,826,000                                       
      net cash from operating activities
    		-107,505,000 -128,236,000 -131,617,000 -65,570,000 -101,500,000 -99,313,000 -129,507,000 -74,037,000 -96,205,000 -121,805,000 -122,286,000 -98,190,000 -84,040,000 -90,475,000 -26,811,000 -44,737,000 -38,770,000 -29,496,000 -29,519,000 52,150,000 14,367,000 -27,439,000 -30,135,000 -19,055,000 -20,268,000 -24,677,000 -26,907,000 -12,327,000 -32,235,000 -26,846,000 -29,807,000 -24,071,000 -25,483,000 -31,261,000 -20,944,000 77,829,000 -12,122,000 -11,218,000 -17,507,000 -9,942,000 -10,347,000 -9,187,000 34,359,000 -8,130,000 -9,515,000 -9,376,000 -17,822,000 -12,429,000 -12,222,000 -8,737,000 -13,178,000 -12,208,000 -66,407,000 34,729,000 
      capex
    		-10,096,000 -2,809,000 -4,170,000 1,593,000 -307,000 -1,686,000 1,754,000 -77,000 -220,000 -717,000 71,000 -4,450,000 -9,386,000 2,235,000 887,000 -16,746,000 -13,984,000 -3,297,000 -2,863,000 -6,555,000 -2,592,000 -864,000 -1,041,000 -1,306,000 -1,006,000 -50,000 -257,000 -210,000 -358,000 -60,000 -261,000 -780,000 -451,000 -258,000 -1,388,000 -854,000 -306,000 -16,000 -420,000 -204,000 -53,000 -175,000 -130,000 -247,000 -100,000 -424,000 -333,000 -252,000 -177,000 -13,000 -163,000 -154,000 1,088,000 -1,655,000 
      free cash flows
    		-117,601,000 -131,045,000 -135,787,000 -63,977,000 -101,807,000 -100,999,000 -127,753,000 -74,114,000 -96,425,000 -122,522,000 -122,215,000 -102,640,000 -93,426,000 -88,240,000 -25,924,000 -61,483,000 -52,754,000 -32,793,000 -32,382,000 45,595,000 11,775,000 -28,303,000 -31,176,000 -20,361,000 -21,274,000 -24,727,000 -27,164,000 -12,537,000 -32,593,000 -26,906,000 -30,068,000 -24,851,000 -25,934,000 -31,519,000 -22,332,000 76,975,000 -12,428,000 -11,234,000 -17,927,000 -10,146,000 -10,400,000 -9,362,000 34,229,000 -8,377,000 -9,615,000 -9,800,000 -18,155,000 -12,681,000 -12,399,000 -8,750,000 -13,341,000 -12,362,000 -65,319,000 33,074,000 
      cash flows from investing activities:
    		                                                      
      purchases of investments
    		-335,452,000 -222,966,000 -159,105,000 -121,125,000 -214,401,000 -815,235,000 -142,655,000 -226,115,000 -117,725,000 -201,592,000 -89,779,000 -125,179,000 -467,177,000 -69,910,000 -193,127,000 -31,592,000 -321,589,000 -105,661,000 -66,200,000 -269,278,000 -138,681,000 -17,274,000 -10,592,000 -136,085,000 -41,637,000 -58,866,000 -41,295,000 -51,796,000 -56,220,000 -107,984,000 -24,224,000 -25,956,000 -12,926,000 -68,761,000 -132,770,000 -65,189,000 -9,260,000 -20,563,000 -50,146,000 -20,908,000 -29,003,000 -15,815,000 -49,840,000 -13,799,000 -5,557,000 -32,217,000 -55,470,000 -11,148,000 -7,761,000 -10,747,000 11,255,000 -36,393,000 17,000,000 -26,400,000 
      investment in non-marketable equity security
    		0 0 -5,000,000                                                    
      maturities of investments
    		  275,725,000 233,278,000 170,049,000 165,602,000 175,296,000 144,783,000 190,984,000 284,437,000 250,701,000 157,633,000 181,136,000 136,035,000 129,790,000 96,681,000 128,572,000 133,334,000 64,250,000 99,154,000 40,250,000                                  
      sales of investments
    		1,000       -2,000 0 0 4,977,000     0 0 0 3,300,000                                    
      purchases of property and equipment
    		-9,354,000 -4,145,000 -5,664,000 -1,290,000 -701,000   -77,000 -220,000 -717,000 -402,000 -3,205,000 -6,331,000 -857,000 -942,000 -17,754,000 -15,700,000 -8,792,000 -6,626,000 -6,555,000 -2,592,000 -864,000 -1,041,000 -1,306,000 -1,006,000 -50,000 -257,000 -210,000 -358,000 -60,000 -261,000 -780,000 -451,000 -258,000 -1,388,000 -854,000 -306,000 -16,000 -420,000 -204,000 -53,000 -175,000 -130,000 -247,000 -100,000 -424,000 -333,000 -252,000 -177,000 -13,000 -163,000 -154,000 1,088,000 -1,655,000 
      net cash from investing activities
    		-70,979,000 52,881,000 105,956,000 110,863,000 -45,053,000 -651,548,000 32,641,000 -81,411,000 73,039,000 82,128,000 165,497,000 29,249,000 -292,372,000 65,268,000 -64,279,000 47,335,000 -208,717,000 18,881,000 -5,276,000 -173,618,000 -101,023,000 34,637,000 43,489,000 -105,266,000 13,682,000 -2,767,000 19,644,000 26,508,000 2,677,000   30,763,000 39,658,000 -23,949,000 -112,300,000 -41,970,000 13,971,000 -3,916,000 -20,161,000 25,411,000 11,306,000 11,439,000 -32,093,000 6,304,000 10,067,000 8,440,000 -28,860,000 5,813,000 10,470,000 5,052,000 7,539,000 4,704,000 798,000 2,931,000 
      cash flows from financing activities:
    		                                                      
      repayment of finance lease liabilities
    		0 -2,000 -202,000 -243,000 -236,000 -233,000 -227,000 -222,000 -217,000 -212,000 -207,000 -105,000 -424,000 -267,000 -148,000                                        
      repayment of term loans
    		-2,709,000 -2,696,000 -2,682,000 -2,671,000 -2,658,000                                                  
      repayment of convertible debt
    		           0                                           
      proceeds from issuance of convertible debt
    		           0                                           
      proceeds from rpi transactions
    		0   0 0                                                  
      proceeds from issuance of common stock related to at-the-market offering, net of issuance costs
    		   0 0 0 93,640,000 162,921,000                                               
      proceeds from issuance of common stock related to public offering, net of issuance costs
    		   0 0                                                  
      proceeds from issuance of common stock related to private placement, net of issuance costs
    		   0 0                                                  
      proceeds from issuance of common stock under equity incentive and stock purchase plans
    		6,935,000 6,745,000 7,651,000 6,480,000 6,319,000 10,685,000 29,532,000 6,101,000 3,124,000 5,687,000 3,547,000                                            
      taxes paid related to net share settlement of equity awards
    		-720,000 -514,000 -13,000 -1,182,000 0 0 -18,449,000 0 0 0 -10,517,000                                            
      net cash from financing activities
    		330,466,000 78,533,000 4,754,000 2,384,000 3,425,000 821,011,000 103,791,000 168,800,000 54,219,000 5,475,000 -7,177,000 29,885,000 389,019,000 3,416,000 93,846,000 19,506,000 300,895,000 3,175,000 -3,596,000 3,641,000 226,334,000 4,160,000 -11,000 121,120,000 11,859,000 22,396,000 4,416,000 451,000 10,227,000 2,978,000 -524,000 2,194,000 1,434,000 106,557,000 115,734,000 715,000 727,000 589,000 14,861,000 23,645,000 164,000 41,000 65,000 9,134,000 0 35,000 39,780,000 7,516,000 5,000 2,667,000 16,740,000 2,658,000 -28,755,000 27,001,000 
      effect of exchange rate changes on cash
    		46,000 -682,000 -270,000  -126,000                                                  
      net increase in cash, cash equivalents, and restricted cash
    		152,028,000 2,496,000 -21,177,000 47,969,000 -143,254,000 70,166,000 6,952,000 13,332,000 31,053,000 -34,202,000 36,034,000                                            
      cash, cash equivalents, and restricted cash, beginning of period
    		0 0 95,232,000 0 0 0 113,399,000 0 0 0 67,182,000                                            
      cash, cash equivalents, and restricted cash, end of period
    		152,028,000 2,496,000 74,055,000 47,969,000 -143,254,000 70,166,000 120,351,000 13,332,000 31,053,000 -34,202,000 103,216,000                                            
      supplemental cash flow disclosures:
    		                                                      
      cash paid for interest
    		9,621,000 606,000 9,647,000 636,000 14,456,000 672,000 10,206,000 317,000 31,000 9,907,000 40,000 9,610,000 81,000 2,760,000 2,714,000                                        
      non-cash investing and financing activities:
    		                                                      
      right-of-use assets recognized in exchange for operating lease obligations
    		2,926,000 0 3,501,000 -28,000 198,000 133,000 178,000     8,592,000                                           
      amounts unpaid for purchases of property and equipment
    		-742,000 1,336,000 1,494,000 2,883,000 394,000 -1,686,000 1,754,000    473,000 -1,245,000 -3,055,000 3,092,000 1,829,000 1,008,000 1,716,000 5,495,000 3,763,000                                    
      issuance of common stock in connection with repurchase of convertible note
    		           0                                           
      maturities and paydown of investments
    		                                                      
      non-cash interest expense on liabilities related to revenue participation right purchase agreement
    		                                                      
      loss on disposition of property and equipment
    		                                                      
      loss on extinguishment of debt
    		           0 0 0 2,693,000                                        
      loss on inducement of convertible debt
    		           0                                           
      debt extinguishment costs
    		           0 0 0 -2,409,000                                        
      cash settlement of capped call options associated with 2026 notes
    		                                                      
      effect of exchange rate changes
    		      27,000                                                
      right-of-use assets recognized in exchange for finance lease obligations
    		           0 0 352,000 703,000                                        
      repayment of term loan
    		      -705,000     0 0 0 -47,651,000                                        
      impairment of right-of-use assets
    		                                                      
      proceeds from public offerings of common stock, net of discounts, commissions and offering cost
    		               0    0                                   
      proceeds from private placement
    		                   0                                   
      proceeds from 2022 rpi transactions
    		       0                                               
      loss on investments
    		        0 1,000 34,000                                            
      gain on investment
    		                                                      
      claims settlement under section 16
    		                   0 0 0 2,151,000                                
      net increase in cash, cash equivalents, and restricted cash equivalents
    		                                                      
      cash, cash equivalents, and restricted cash equivalents, beginning of period
    		                                                      
      cash, cash equivalents, and restricted cash equivalents, end of period
    		                                                      
      proceeds from 2020 rpi transactions
    		            0 0 149,581,000                                        
      proceeds from and payments for stock-based award activities
    		            6,187,000 3,683,000 -5,527,000  3,990,000                                      
      net increase in cash and cash equivalents
    		              2,756,000 22,104,000 53,408,000 -7,440,000 -38,391,000 -117,827,000 139,678,000 11,358,000 13,343,000     14,632,000 -19,331,000   8,886,000 15,609,000   36,574,000 2,576,000 -14,545,000 -22,807,000 39,114,000 1,123,000 2,293,000 2,331,000 7,308,000 552,000   900,000 -1,747,000 -1,018,000 11,101,000 -4,846,000 -94,364,000 64,661,000 
      cash and cash equivalents, beginning of period
    		            0 0 112,666,000 0 0 0 82,985,000 0 0 0 36,433,000 0 0 0 42,256,000 0 0 0 125,206,000 0 0 0 66,874,000 0 0 0 65,076,000 0 0 0 20,215,000 0 0 0 20,158,000 0 14,907,000 18,833,000 -8,047,000 25,561,000 77,177,000 39,387,000 
      cash and cash equivalents, end of period
    		            12,607,000 -21,791,000 115,422,000 22,104,000 53,408,000 -7,440,000 44,594,000 -117,827,000 139,678,000 11,358,000 49,776,000 -3,201,000 5,273,000 -5,048,000 39,409,000 14,632,000 -19,331,000 -68,056,000 115,011,000 8,886,000 15,609,000 51,347,000 49,364,000 36,574,000 2,576,000 -14,545,000 42,269,000 39,114,000 1,123,000 2,293,000 22,546,000 7,308,000 552,000 -901,000 13,256,000 900,000 13,160,000 17,815,000 3,054,000 20,715,000 -17,187,000 104,048,000 
      depreciation and amortization of property and equipment
    		             1,407,000 1,341,000 734,000 462,000 543,000 537,000 471,000 536,000 416,000 408,000           439,000 421,000 224,000 177,000 170,000 170,000 151,000 146,000 147,000 145,000 137,000 126,000 122,000 105,000 88,000 124,000 178,000 324,000 489,000 519,000 755,000 
      net decrease in cash and cash equivalents
    		                       -3,201,000 5,273,000 -5,048,000 -2,847,000    -10,195,000    -17,510,000            -6,902,000        
      non-cash stock-based compensation expense
    		              8,985,000 6,711,000 7,767,000 7,093,000 5,261,000 4,877,000 4,692,000 4,527,000 3,524,000                                
      contract assets
    		                       0 575,000 1,897,000 2,082,000 -8,383,000 4,499,000 5,826,000 3,212,000                        
      proceeds from stock-based award activities
    		                  -3,596,000 2,132,000                                   
      net proceeds from long-term debt, net of debt discount and issuance costs
    		                                                      
      net proceeds from convertible notes, net of debt discount and issuance costs
    		                                                      
      issuance of common stock under at-the-market offering, net of issuance costs
    		                                                      
      purchase of capped call options associated with convertible notes
    		                                                      
      non-cash interest expense on liability related to sale of future royalties
    		                2,985,000 2,900,000 2,822,000 5,673,000 5,481,000 5,932,000 5,706,000 5,533,000 5,321,000 5,064,000 4,819,000 4,741,000 4,559,000 4,338,000 4,129,000 4,074,000 3,918,000 3,729,000 2,307,000                    
      right-of-use assets recognized in exchange for lease obligations
    		                0 5,321,000 77,887,000 0 0 0 1,106,000 0 0                              
      operating lease right-of-use assets
    		                 2,002,000 1,124,000   1,042,000 1,016,000 921,000 898,000 877,000 856,000                            
      operating lease and other non-current liabilities
    		                                                      
      prepaid and other current assets
    		                   -2,477,000                                   
      operating lease right-of-use assets and other assets
    		                   -1,884,000                                   
      contract liabilities
    		                           0 -8,132,000 -1,416,000 -9,202,000                        
      sales of property and equipment
    		                                                      
      proceeds from issuance under employee stock purchase plan
    		                                                      
      net proceeds from long-term debt, net of debt discount and issuance cost
    		                        0                              
      proceeds from stock based award activities
    		                        459,000                              
      sales and maturities of investments
    		                      55,122,000 32,125,000 56,325,000 56,149,000 61,196,000 78,500,000 59,255,000 63,856,000 44,621,000                        
      proceeds from and payments for stock based award activities
    		                      -2,162,000                                
      issuance of common stock under at the market offering, net of issuance costs
    		                       0 11,400,000                              
      issuance of warrants in connection with long-term debt
    		                       0 0                              
      non-cash equity-related expense
    		                        2,783,000 2,819,000 2,282,000  2,572,000 2,505,000 2,403,000                        
      supplemental cash flow disclosure - non-cash investing and financing activity:
    		                                                      
      public offerings of common stock, net of issuance costs
    		                          5,117,000                            
      proceeds from common stock award exercise
    		                          31,000                            
      issuance of equity for stock-based awards and warrants
    		                          -732,000  329,000 2,978,000 -524,000                        
      right-of-use assets obtained in exchange for lease obligations
    		                          10,686,000                            
      stock-based compensation
    		                                2,447,000 2,219,000 1,922,000 1,880,000 1,866,000 1,789,000 1,611,000 1,348,000 1,121,000 1,202,000 896,000 886,000 891,000 859,000 694,000 656,000 966,000 943,000 498,000 994,000 1,713,000 1,160,000 
      net gain on disposal of equipment
    		                                                      
      non-cash interest expense related to long-term debt
    		                             411,000 177,000 217,000 140,000 139,000 139,000                    
      proceeds from public offerings of common stock, net of issuance costs
    		                               0 -8,000 94,877,000 17,355,000         9,102,000 0 0 39,869,000        
      proceeds from sale of future royalties, net of issuance costs
    		                               0 0 0 90,621,000                    
      proceeds from issuance of common stock related to sale of future royalties, net of issuance costs
    		                               0 0 0 7,560,000                    
      proceeds from stock based award activities and warrants
    		                               933,000 1,442,000                      
      supplemental disclosure of cash flow information
    		                                                      
      cash paid for taxes
    		                                                      
      (gain) loss on disposal of equipment
    		                                                      
      sale of future royalties, net of issuance costs
    		                                                      
      issuance of common stock related to sale of future royalties, net of issuance costs
    		                                                      
      issuance of long term debt, net of debt discount and issuance costs
    		                                                      
      net cash from in investing activities
    		                              20,136,000                        
      non-cash stock-based compensation
    		                                                      
      gain on sale of investments
    		                                       -2,000    0 0          
      net proceeds from long term debt, net of debt discount and issuance costs
    		                                                      
      proceeds from sales and maturities of investments
    		                                53,035,000 45,070,000 21,858,000 24,073,000 23,536,000 16,631,000 30,405,000 46,522,000 40,362,000 27,429,000 17,877,000 20,350,000 15,724,000 41,081,000 26,943,000 17,203,000 18,408,000 15,667,000 -3,464,000 40,810,000 -18,501,000 31,077,000 
      proceeds from sale of property and equipment
    		                                    1,000                  
      proceeds from long term debt, net of debt discount and issuance costs
    		                                   0 0 0 14,996,000                
      gain on disposal of equipment
    		                                 0 -82,000                    
      related party accounts receivable
    		                                  -885,000 66,976,000 -66,974,000 -26,000 12,000 36,000 -43,000 965,000 45,676,000    -2,111,000  -324,000 -69,000 -150,000 169,000 -41,913,000 41,938,000 
      proceeds (payments) from stock based award activities and warrants
    		                                  198,000 715,000 727,000 589,000 -135,000                
      non-cash interest expense
    		                                   139,000 138,000 138,000 119,000              23,000 23,000 
      proceeds from sales of property and equipment
    		                                               10,000       
      loss on disposal of property and equipment
    		                                                     3,000 
      gain on disposal of property and equipment
    		                                                      
      amortization of debt discount
    		                                                      
      related party payables and accrued liabilities
    		                                               0 -150,000 -12,000 1,000 10,000 33,000 -49,000 
      payments from stock based award activities and warrants
    		                                           32,000           
      proceeds(payments) from stock based award activities and warrants
    		                                         41,000 65,000            
      non-cash restructuring expenses, net of reversals
    		                                                 -41,000     
      decrease in restricted cash
    		                                                      
      proceeds from draw down of committed equity financing facilities and at-the-market facility, net of commission and issuance costs
    		                                                 2,819,000     
      proceeds from issuance of preferred stock, net of issuance costs
    		                                                      
      repayment of equipment financing lines
    		                                                 -152,000 -72,000 -424,000 -1,200,000 -885,000 
      accounts receivable and related party accounts receivable
    		                                            -871,000          
      loss on disposal of equipment
    		                                                      
      license fee receivable
    		                                                      
      proceeds (payments) from stock based award activities, and warrants
    		                                              -89,000        
      proceeds from initial public offering, sale of common stock to related party, and public offerings, net of issuance costs
    		                                               0       
      proceeds from other issuances of common stock and warrants
    		                                               7,516,000 5,000      
      non-cash impairment charges
    		                                                      
      non-cash forgiveness of loans to officers
    		                                                      
      non-cash warrant expense
    		                                                      
      other non-cash expenses
    		                                                      
      proceeds from sales of auction rate securities
    		                                                      
      issuance of related party notes receivable
    		                                                      
      proceeds from repayments of notes receivable
    		                                                      
      repurchase of common stock
    		                                                      
      proceeds from loan with ubs
    		                                                      
      repayment of loan with ubs
    		                                                   -328,000   
      proceeds from equipment financing lines
    		                                                     1,743,000 
      non-cash forgiveness of loan to officers
    		                                                      
      tax benefit from stock-based compensation
    		                                                      
      tax expense from stock-based compensation
    		                                                      
      increase in restricted cash
    		                                                 145,000 -92,000 441,000 1,111,000 -91,000 
      proceeds from other issuances of common stock and warrants, net of issuance costs
    		                                                      
      accrued liabilities
    		                                                  47,000 -1,643,000 367,000 -916,000 
      proceeds from draw down of committed equity financing and at-the-market facility, net of issuance costs
    		                                                      
      non-cash forgiveness of loan to officer
    		                                                      
      proceeds from draw down of committed equity financing facility, net of issuance costs
    		                                                   3,370,000   
      proceeds from other issuances of common stock
    		                                                   40,000 190,000 141,000 
      non-cash restructuring expenses
    		                                                      
      proceeds from initial public offering, sale of common stock to related party and public offerings, net of issuance costs
    		                                                      
      allowance for doubtful accounts
    		                                                      
      non-cash expense related to warrants issued for equipment financing lines and facility lease
    		                                                      
      proceeds from payments of related party notes receivable
    		                                                      
      non-cash expense for acceleration of options
    		                                                      
      proceeds from payments of notes receivable
    		                                                      
      proceeds from initial public offering, net of issuance costs
    		                                                      
      proceeds from sale of common stock to related party, net of issuance costs
    		                                                     26,009,000 
      proceeds from public offerings, net of issuance costs
    		                                                     -7,000 
      non-cash compensation expense for acceleration of options
    		                                                      
      proceeds from sale of common stock to related party
    		                                                      
      related party accrued liabilities
    		                                                      
      operating activities
    		                                                      
      depreciation and amortization
    		                                                      
      gain or loss on sale of property and equipment
    		                                                      
      non-cash proceeds from sale of property and equipment
    		                                                      
      related party receivable
    		                                                      
      prepaids and other current assets
    		                                                      
      other assets
    		                                                      
      investing activities
    		                                                      
      investment in restricted cash
    		                                                      
      issuance of notes receivable
    		                                                      
      purchases of short-term and long-term investments
    		                                                      
      financing activities
    		                                                      
      repayment of equipment loan
    		                                                      
      proceeds from issuance of common stock
    		                                                      
      proceeds from issuance of preferred stock
    		                                                      
      additional equipment loan taken
    		                                                      
      increase in cash and cash equivalents
    		                                                      
      supplemental disclosure of cash flow information:
    		                                                      
      supplemental disclosure of significant non-cash investing and financing activities:
    		                                                      
      deferred stock-based compensation
    		                                                      
      penalty on restructuring
    		                                                      
    The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.