7Baggers
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-09-30 2010-06-30 2010-03-31 2009-09-30 2009-06-30 2009-03-31 2008-09-30 2008-06-30 2008-03-31 2007-09-30 2007-06-30 2007-03-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-06-30 2004-03-31 
      
    		                                                                                 
      assets
    		                                                                                 
      current assets:
    		                                                                                 
      cash and cash equivalents
    		225,467,000 74,940,000 73,680,000 94,857,000 46,888,000 190,142,000 119,976,000 113,024,000 99,692,000 68,639,000 101,616,000 65,582,000 106,238,000 93,631,000 115,422,000 112,666,000 90,562,000 37,154,000 44,594,000 82,985,000 200,812,000 61,134,000 49,776,000 36,433,000 39,634,000 34,361,000 39,409,000 42,256,000 27,624,000 46,955,000 115,011,000 125,206,000 116,320,000 100,711,000 49,364,000 66,874,000 30,300,000 27,724,000 42,269,000 65,076,000 25,962,000 24,839,000 22,546,000 20,215,000 12,907,000 12,355,000 13,256,000 20,158,000 19,258,000 17,057,000 13,160,000 14,907,000 15,390,000 63,654,000 17,815,000 18,833,000 18,591,000 23,769,000 15,452,000 30,439,000 18,365,000 20,715,000 23,715,000 85,032,000 48,489,000 70,636,000 86,861,000 105,540,000 108,491,000 111,223,000 104,048,000 48,214,000 49,766,000 73,111,000 13,515,000 11,803,000 10,910,000 14,816,000 13,061,000 17,650,000 8,916,000 
      short-term investments
    		737,068,000 783,195,000 864,538,000 981,157,000 964,804,000 866,633,000 498,985,000 501,800,000 439,547,000 497,083,000 562,346,000 716,995,000 761,426,000 492,395,000 493,552,000 358,972,000 387,074,000 313,147,000 380,983,000 381,075,000 209,452,000 151,929,000 170,930,000 188,679,000 126,405,000 138,507,000 137,213,000 156,475,000 182,686,000 184,986,000 136,443,000 143,685,000 191,247,000 211,340,000 157,192,000 89,375,000 48,309,000 62,614,000 61,153,000 46,366,000 72,023,000 80,344,000 85,322,000 63,013,000 65,589,000 65,395,000 69,090,000 57,570,000 62,384,000 58,596,000 48,438,000 59,093,000 60,220,000 26,821,000 25,265,000 30,190,000 38,994,000 43,143,000 44,449,000 46,780,000 61,739,000 67,091,000 79,723,000 29,691,000 15,607,000    44,450,000 44,250,000 65,499,000 40,478,000 45,155,000 28,150,000 62,697,000 68,761,000 78,191,000 86,809,000 92,637,000 102,269,000 18,941,000 
      accounts receivable
    		1,808,000 8,410,000 2,012,000 16,650,000 244,000  834,000 1,283,000 2,499,000 985,000 1,006,000 147,000 2,294,000 1,973,000 6,056,000 51,819,000 644,000 2,701,000 4,514,000 4,420,000 4,965,000 2,254,000 2,704,000 5,163,000 6,576,000 8,993,000 4,165,000 2,231,000 9,156,000 236,000 37,000 1,112,000 10,000,000                                               13,000  
      prepaid expenses and other current assets
    		13,006,000 19,997,000 15,823,000 15,276,000 6,665,000 11,035,000 18,909,000 11,944,000 19,678,000 19,868,000 15,661,000 12,462,000 14,317,000 14,251,000 8,496,000 12,215,000 16,661,000 11,227,000 3,026,000 5,741,000 3,183,000 3,637,000 2,528,000 3,477,000                                                          
      total current assets
    		977,349,000 886,542,000 956,053,000 1,107,940,000 1,018,601,000 1,067,810,000 638,704,000 628,051,000 561,416,000 586,575,000 680,629,000 795,186,000 884,275,000 602,250,000 623,526,000 535,672,000 494,941,000 364,229,000 433,117,000 474,221,000 418,412,000 218,954,000 225,938,000 233,752,000 176,535,000 184,951,000 186,400,000 207,674,000 227,269,000 244,229,000 272,339,000 274,295,000 321,987,000 316,996,000 211,023,000 158,633,000 148,184,000 96,618,000 106,118,000 113,107,000 100,515,000 107,900,000 110,810,000 131,131,000 81,491,000 80,078,000 86,054,000 79,338,000 83,321,000 93,620,000 63,665,000 76,427,000 78,769,000 92,960,000 45,221,000 51,140,000 59,871,000 69,804,000 62,954,000 79,258,000 90,139,000 107,089,000 128,151,000 137,100,000 65,332,000 72,783,000 89,335,000 107,510,000 155,205,000 158,021,000 171,660,000 91,413,000 97,590,000 103,107,000 78,864,000 83,655,000 92,282,000 104,825,000  122,777,000 31,131,000 
      long-term investments
    		288,817,000 178,201,000 150,687,000 145,055,000 269,168,000 305,361,000 15,376,000 40,534,000 15,468,000 26,871,000 40,406,000 46,708,000 28,544,000 10,668,000 77,083,000 152,050,000 191,295,000 73,672,000 34,664,000 36,954,000 40,958,000  16,510,000 42,650,000  2,254,000     4,015,000 16,518,000 583,000 20,087,000 50,622,000 7,672,000 7,737,000 7,684,000 5,140,000 179,000  3,035,000 9,653,000  4,003,000 14,352,000 19,515,000 2,502,000 3,754,000    5,543,000             18,230,000 18,749,000 19,082,000           4,555,000 11,550,000 7,789,000 
      property and equipment
    		76,001,000 70,219,000 67,175,000 65,815,000 64,222,000 65,689,000 68,018,000 68,748,000 75,614,000 77,248,000 78,859,000 80,453,000 80,302,000 78,586,000 75,740,000 73,271,000 53,896,000 36,942,000 23,198,000 13,346,000 7,667,000 5,611,000 5,162,000 4,530,000 3,615,000 2,945,000 3,175,000 3,204,000 2,687,000 2,598,000 3,156,000 3,568,000 3,294,000 3,268,000 3,488,000 3,637,000 2,049,000 1,659,000 1,760,000 1,751,000 1,481,000 1,571,000 1,551,000 1,637,000 1,491,000 1,513,000 1,508,000 1,221,000 804,000 809,000 898,000 997,000 906,000 994,000 1,132,000 1,310,000 1,514,000 1,705,000 2,041,000 2,574,000 2,953,000 3,282,000 3,865,000 4,249,000 4,714,000 5,605,000 6,728,000 7,201,000 7,820,000 8,132,000 8,667,000 7,178,000 5,920,000 5,949,000 6,178,000 5,920,000 6,368,000 6,727,000 7,336,000 7,764,000 8,170,000 
      operating lease right-of-use assets
    		77,580,000 76,120,000 77,439,000 75,158,000 76,344,000 77,249,000 78,170,000 78,987,000 79,929,000 80,866,000 81,802,000 82,737,000 75,076,000 72,161,000 72,646,000 73,138,000 80,725,000 83,006,000 79,687,000                                                               
      other assets
    		16,810,000 14,553,000 12,697,000 7,705,000 7,725,000 7,679,000 7,814,000 7,996,000 8,187,000 8,339,000 8,119,000 9,691,000 7,764,000 8,052,000 7,258,000 7,188,000 6,682,000 6,453,000 6,396,000      7,243,000 8,068,000 9,036,000 300,000 323,000 412,000 416,000 429,000 449,000 279,000 241,000 200,000 200,000 200,000 200,000 200,000 200,000 200,000 200,000 200,000 200,000 200,000 200,000 127,000 127,000 126,000 127,000 127,000 127,000 127,000 127,000 127,000 178,000 209,000 228,000 298,000 291,000 289,000 296,000 310,000 327,000 372,000 368,000 349,000 324,000 318,000 317,000 442,000 526,000 615,000 796,000 818,000 814,000 794,000 776,000 743,000 734,000 
      total assets
    		1,436,557,000 1,225,635,000 1,264,051,000 1,401,673,000 1,436,060,000 1,523,788,000 808,082,000 824,316,000 740,614,000 779,899,000 889,815,000 1,014,775,000 1,075,961,000 771,717,000 856,253,000 841,319,000 827,539,000 564,302,000 577,062,000 533,803,000 474,112,000 232,495,000 256,582,000 289,814,000 187,393,000 198,218,000 198,611,000 211,178,000 230,279,000 247,239,000 279,926,000 294,810,000 326,313,000 340,630,000 265,374,000 170,142,000 158,170,000 106,161,000 113,218,000 115,237,000 102,196,000 112,706,000 122,214,000 132,968,000 87,185,000 96,143,000 107,277,000 83,188,000 88,006,000 94,555,000 64,690,000 77,551,000 85,345,000 94,081,000 46,531,000 52,773,000 61,778,000 72,157,000 65,662,000 82,918,000 94,616,000 111,893,000 134,164,000 144,069,000 92,922,000 100,043,000 119,366,000 138,338,000 168,702,000 172,812,000 186,995,000 104,649,000 109,578,000 114,668,000 91,461,000 95,901,000 105,202,000 117,832,000  149,503,000 56,169,000 
      liabilities and stockholders’ deficit
    		                                                                                 
      current liabilities:
    		                                                                                 
      accounts payable
    		22,084,000 16,228,000 13,942,000 20,369,000 11,581,000 9,470,000 12,967,000 21,507,000 13,796,000 12,561,000 17,357,000 25,611,000 14,429,000 14,078,000 19,836,000 21,087,000 16,222,000 14,928,000 7,766,000 8,050,000 6,738,000 2,920,000 3,527,000 8,160,000 3,412,000 5,194,000 2,547,000 3,764,000 2,024,000 1,336,000 2,424,000 5,253,000 4,079,000 1,783,000 3,042,000 4,236,000 668,000 2,846,000 547,000 2,238,000 1,907,000 1,601,000 1,392,000 1,361,000 1,646,000 985,000 1,689,000 3,709,000 1,789,000 1,801,000 1,086,000 2,002,000 1,518,000 1,046,000 926,000 1,196,000 1,450,000 1,005,000 1,045,000 1,013,000 1,196,000 1,700,000 1,349,000 924,000 1,256,000 1,013,000 1,659,000 2,306,000 2,505,000 2,221,000 1,815,000 2,448,000 1,890,000 1,617,000 2,352,000 1,366,000 773,000 1,252,000 2,059,000 1,926,000 1,032,000 
      accrued liabilities
    		61,633,000 52,315,000 43,358,000 55,323,000 49,826,000 39,813,000 40,123,000 42,641,000 32,954,000 31,470,000 35,632,000 44,096,000 40,229,000 36,702,000 29,477,000 34,370,000 31,772,000 22,394,000 14,806,000 19,315,000 14,486,000 13,688,000 9,677,000 12,123,000 13,139,000 11,828,000 12,944,000 15,757,000 15,652,000 16,090,000 15,545,000 17,392,000 18,455,000 13,545,000 17,503,000 18,047,000 17,783,000 9,503,000 7,877,000 8,421,000 6,759,000 6,429,000 3,981,000 5,400,000 6,012,000 6,911,000 7,678,000 8,272,000 9,886,000 6,706,000 4,690,000 4,877,000 2,942,000 2,943,000 3,541,000 3,232,000 3,263,000 3,737,000 4,279,000 4,446,000 4,411,000 4,281,000 6,207,000 8,230,000 6,569,000 8,750,000 8,024,000 8,190,000 7,292,000 5,740,000 5,647,000 6,424,000 5,502,000 4,215,000 4,137,000 4,282,000 3,994,000 3,780,000 3,697,000 2,918,000 3,407,000 
      short-term operating lease liabilities
    		20,647,000 19,585,000 19,574,000 18,978,000 18,856,000 18,507,000 18,230,000 17,891,000 17,236,000 15,701,000 14,263,000 12,829,000 16,056,000 14,303,000 14,490,000 14,863,000                                                                  
      current portion of long-term debt
    		17,280,000 14,400,000 12,960,000 11,520,000 11,520,000 11,520,000 11,520,000 10,080,000         16,875,000 11,250,000 5,625,000        6,212,000 2,607,000 3,778,000 1,703,000   9,829,000 7,315,000 4,825,000 2,500,000                                              
      derivative liabilities measured at fair value
    		16,900,000 17,600,000 11,700,000 11,300,000 12,500,000 13,200,000                                                                            
      deferred revenue
    		1,612,000 1,344,000 52,370,000 52,370,000                                                      263,000 17,000   217,000       12,234,000 12,234,000 12,234,000   700,000        
      other current liabilities
    		1,988,000 9,592,000 5,822,000 9,814,000 5,529,000 10,267,000 6,015,000 10,559,000 13,737,000 5,885,000 7,968,000 2,081,000 5,782,000 1,760,000 3,044,000 1,540,000 2,413,000 1,004,000 2,438,000 1,049,000 2,406,000 1,013,000 2,507,000 1,124,000 389,000 399,000 75,000 66,000 38,000 28,000 235,000 227,000 424,000 474,000                                                
      total current liabilities
    		142,144,000 131,064,000 159,726,000 179,674,000 109,812,000 102,777,000 88,855,000 102,678,000 77,723,000 65,617,000 75,220,000 84,617,000 76,496,000 66,843,000 66,847,000 71,860,000 80,868,000 61,766,000 35,930,000 31,199,000 27,573,000 22,696,000 20,741,000 26,023,000 21,517,000 21,959,000 26,277,000 22,194,000 21,492,000 27,289,000 38,546,000 32,444,000 42,357,000 31,059,000 36,796,000 33,258,000 29,334,000 26,272,000 24,683,000 31,649,000 30,143,000 29,112,000 25,385,000 23,855,000 12,986,000 16,917,000 19,792,000 26,704,000 45,011,000 34,046,000 5,819,000 7,105,000 4,589,000 3,989,000 4,467,000 4,592,000 5,034,000 5,505,000 6,042,000 6,487,000 6,875,000 17,534,000 20,469,000 23,248,000 22,062,000 24,467,000 24,952,000 26,294,000 26,238,000 24,388,000 23,850,000 12,405,000 10,650,000 9,685,000 11,264,000 10,764,000 10,476,000 12,097,000  10,468,000 9,231,000 
      term loans
    		158,747,000 159,058,000 92,025,000 93,227,000 93,017,000 92,831,000                                                                            
      convertible notes
    		889,524,000 553,987,000 553,143,000 552,370,000 551,481,000 550,600,000 549,790,000 548,989,000 548,134,000 547,288,000 546,513,000 545,808,000 544,986,000 134,674,000 134,511,000 95,471,000 93,885,000 92,348,000 90,889,000 89,504,000 88,102,000 86,743,000 85,455,000 84,205,000                                                          
      liabilities related to revenue participation right purchase agreements
    		504,498,000 489,503,000 476,296,000 462,192,000 448,509,000 435,112,000 390,219,000 379,975,000 370,049,000 313,163,000 306,814,000 300,501,000 291,260,000 282,266,000 275,235,000                                                                   
      long-term operating lease liabilities
    		110,655,000 111,028,000 113,353,000 112,582,000 114,752,000 116,718,000 118,554,000 120,427,000 122,216,000 123,829,000 125,341,000 126,895,000 114,405,000 112,732,000 112,023,000 112,229,000                                                                  
      liabilities related to rpi transactions measured at fair value
    		150,500,000 147,700,000 133,100,000 137,000,000 132,400,000 117,200,000                                                                            
      other non-current liabilities
    		1,612,000 2,015,000 2,821,000    2,000 186,000 408,000 625,000 837,000 1,044,000 1,247,000 1,444,000 3,211,000 4,457,000                                                                  
      total liabilities
    		1,957,680,000 1,594,355,000 1,530,464,000 1,537,045,000 1,449,971,000 1,415,238,000 1,204,242,000 1,210,639,000 1,179,415,000 1,113,014,000 1,118,835,000 1,122,675,000 1,091,938,000 660,303,000 739,992,000 597,456,000 578,519,000 547,813,000 509,216,000 420,420,000 324,507,000 310,575,000 302,293,000 300,751,000 207,262,000 203,114,000 195,239,000 185,244,000 178,210,000 172,069,000 180,327,000 184,968,000 179,275,000 165,629,000 169,991,000 75,781,000 74,920,000 57,415,000 55,312,000 46,647,000 34,896,000 37,845,000 38,062,000 40,904,000 13,555,000 17,446,000 21,099,000 28,746,000 48,255,000 42,566,000 6,260,000 7,466,000 4,742,000 4,100,000 4,524,000 4,595,000 5,034,000 5,505,000 6,076,000 6,796,000 7,364,000 18,258,000 21,807,000 25,005,000 45,726,000 42,739,000 46,778,000 51,714,000 59,204,000 61,475,000 65,046,000 19,059,000 16,786,000 15,618,000 17,900,000 17,678,000 17,344,000 20,287,000  21,478,000 20,330,000 
      commitments and contingencies
    		                                                                                 
      stockholders' deficit
    		                                                                                 
      preferred stock
    		                                                                                 
      common stock
    		122,000 119,000 119,000  118,000 117,000 105,000  94,000 94,000 94,000  93,000 85,000 85,000  84,000 72,000 71,000  70,000 60,000 59,000  59,000 58,000 55,000  55,000 55,000 54,000                      142,000 133,000            49,000 49,000 49,000 49,000 47,000 47,000           
      additional paid-in capital
    		2,782,409,000 2,628,829,000 2,595,063,000 2,563,876,000 2,532,328,000 2,500,654,000 1,852,155,000 1,725,823,000 1,537,321,000 1,514,169,000 1,489,814,000 1,481,590,000 1,438,103,000 1,422,127,000 1,406,249,000 1,452,268,000 1,426,051,000 1,117,403,000 1,107,135,000 1,105,470,000 1,096,953,000 865,724,000 857,038,000 853,341,000 813,729,000 799,088,000 775,401,000 768,703,000 765,970,000 762,887,000 757,405,000 755,526,000 752,154,000 748,273,000 639,507,000 612,474,000 609,880,000 607,287,000 604,909,000 603,145,000 592,760,000 591,476,000 590,234,000 589,272,000 579,255,000 578,363,000 577,470,000 537,001,000 528,831,000 528,501,000 519,772,000 518,804,000 517,872,000 517,229,000 460,369,000 456,610,000 453,296,000 452,559,000 431,872,000 425,087,000 423,881,000 417,132,000 411,106,000 409,639,000 393,730,000 384,163,000 382,730,000 381,137,000 376,218,000 366,936,000 365,073,000 301,677,000 294,336,000 287,074,000 249,521,000 243,466,000 243,452,000 243,051,000 243,239,000 242,572,000 7,596,000 
      accumulated other comprehensive income
    		34,000 -158,000 1,545,000 2,398,000 5,387,000           -869,000 -65,000 -22,000 50,000 149,000 958,000 1,337,000 1,613,000 679,000 719,000 761,000 606,000 500,000 447,000 450,000 489,000 343,000 426,000 -86,000 -9,000 137,000 252,000 229,000 156,000 149,000 16,000 12,000  -4,000 24,000 12,000 12,000 7,000 19,000 -1,000 10,000 18,000 13,000 -1,000 -2,000 3,000 8,000 15,000 9,000 7,000 3,000 -7,000 24,000 -3,000 4,000              -188,000 -89,000 67,000 
      accumulated deficit
    		-3,303,688,000 -2,997,510,000 -2,863,140,000 -2,701,764,000 -2,551,744,000 -2,391,199,000 -2,247,881,000 -2,112,238,000 -1,975,342,000 -1,845,920,000 -1,717,283,000 -1,585,994,000 -1,448,614,000 -1,306,304,000 -1,286,484,000 -1,207,620,000 -1,177,050,000 -1,100,964,000 -1,039,410,000 -992,306,000 -948,376,000 -945,201,000 -904,421,000 -865,016,000 -834,376,000 -804,803,000 -772,690,000 -743,324,000 -714,403,000 -688,222,000 -658,349,000 -646,081,000 -605,596,000 -573,239,000 -544,158,000 -518,291,000 -526,923,000 -558,810,000 -547,199,000 -534,744,000 -525,515,000 -516,666,000 -506,115,000 -497,243,000 -505,686,000 -499,715,000 -491,340,000 -482,597,000                                  
      total stockholders' deficit
    		-521,123,000 -368,720,000 -266,413,000 -135,372,000 -13,911,000                                                                             
      total liabilities and stockholders' deficit
    		1,436,557,000 1,225,635,000 1,264,051,000 1,401,673,000 1,436,060,000                                                                             
      preferred stock, 0.001 par value:
    		                                                                                 
      authorized: 10,000,000 shares; issued and outstanding: none
    		                                                                                 
      authorized: 163,000,000 shares
    		                                                                                 
      issued and outstanding: 118,209,139 shares at december 31, 2024 and 101,637,922 shares at december 31, 2023
    		   118,000                                                                              
      liabilities and stockholders’ equity
    		                                                                                 
      stockholders’ equity
    		                                                                                 
      accumulated other comprehensive loss
    		     -1,022,000 -539,000 -10,000 -874,000 -1,458,000 -1,645,000 -3,590,000 -5,559,000 -4,494,000 -3,589,000                            -6,000                       -1,795,000 -1,276,000 -948,000 -13,000 -60,000 -54,000 -22,000 -56,000  -14,000 -43,000 -95,000 -181,000    
      total stockholders’ equity
    		     108,550,000        111,414,000 116,261,000 243,863,000 249,020,000 16,489,000 67,846,000 113,383,000 149,605,000   -10,937,000 -19,869,000 -4,896,000 3,372,000 25,934,000 52,069,000 75,170,000 99,599,000 109,842,000 147,038,000 175,001,000 95,383,000 94,361,000 83,250,000 48,746,000 57,906,000 68,590,000 67,300,000 74,861,000 84,152,000 92,064,000 73,630,000 78,697,000 86,178,000 54,442,000 39,751,000 51,989,000 58,430,000 70,085,000 80,603,000 89,981,000 42,007,000 48,178,000 56,744,000 66,652,000 59,586,000 76,122,000 87,252,000 93,635,000 112,357,000 119,064,000 47,196,000 57,304,000 72,588,000 86,624,000 109,498,000 111,337,000 121,949,000 85,560,000 92,792,000 99,050,000 73,561,000 78,223,000 87,858,000 97,545,000  128,025,000  
      total liabilities and stockholders’ equity
    		     1,523,788,000        771,717,000 856,253,000 841,319,000 827,539,000 564,302,000 577,062,000 533,803,000 474,112,000   289,814,000 187,393,000 198,218,000 198,611,000 211,178,000 230,279,000 247,239,000 279,926,000 294,810,000 326,313,000 340,630,000 265,374,000 170,142,000 158,170,000 106,161,000 113,218,000 115,237,000 102,196,000 112,706,000 122,214,000 132,968,000 87,185,000 96,143,000 107,277,000 83,188,000 88,006,000 94,555,000 64,690,000 77,551,000 85,345,000 94,081,000 46,531,000 52,773,000 61,778,000 72,157,000 65,662,000 82,918,000 94,616,000 111,893,000 134,164,000 144,069,000 92,922,000 100,043,000 119,366,000 138,338,000 168,702,000 172,812,000 186,995,000 104,649,000 109,578,000 114,668,000  95,901,000 105,202,000 117,832,000    
      term loan
    		      56,822,000 58,384,000 60,885,000 62,492,000 64,110,000 63,810,000 63,544,000 62,344,000 61,165,000 47,367,000 30,203,000 35,538,000 40,874,000 46,209,000 45,920,000 45,631,000 45,340,000 45,052,000                                                          
      stockholders’ deficit:
    		                                                                                 
      total stockholders’ deficit
    		      -396,160,000 -386,323,000 -438,801,000 -333,115,000 -229,020,000           -78,080,000 -45,711,000                                                          -97,333,000 
      total liabilities and stockholders’ deficit
    		      808,082,000 824,316,000 740,614,000 779,899,000 889,815,000           232,495,000 256,582,000                                                           
      issued and outstanding: 101,637,922 shares at december 31, 2023 and 94,833,975 shares at december 31, 2022
    		       102,000                                                                          
      preferred stock, 0.001 par value
    		                                                                                 
      liabilities and stockholders’ (deficit) equity
    		                                                                                 
      long-term deferred revenue
    		              87,000,000 87,000,000 87,000,000 87,000,000 87,000,000 87,000,000                                                              
      stockholders’ (deficit) equity:
    		                                                                                 
      issued and outstanding: 94,833,975 shares at december 31, 2022 and 84,799,542 shares at december 31, 2021
    		           94,000                                                                      
      total stockholders’ (deficit) equity
    		           -107,900,000 -15,977,000                                                                     
      total liabilities and stockholders’ (deficit) equity
    		           1,014,775,000 1,075,961,000                                                                     
      stockholders’ equity:
    		                                                                                 
      liabilities related to revenue participation right purchase agreement
    		               179,072,000                                                                  
      issued and outstanding: 84,799,542 shares at december 31, 2021 and 71,015,183 shares at december 31, 2020
    		               84,000                                                                  
      short-term lease liabilities
    		                13,586,000 12,190,000 5,295,000                                                               
      liability related to the sale of future royalties
    		                174,775,000 171,790,000 168,890,000 166,068,000 160,395,000 154,914,000 148,983,000 143,276,000 137,726,000 132,388,000 127,308,000 122,473,000 117,718,000 113,144,000 108,792,000 104,650,000 100,575,000 96,657,000 92,928,000                                               
      long-term lease and other non-current liabilities
    		                111,788,000 99,371,000  440,000 2,517,000                                                             
      long-term lease liabilities
    		                  85,633,000                                                               
      operating lease right-of-use assets and other assets
    		                   9,282,000 7,075,000 7,930,000 8,972,000 8,882,000                                                          
      short-term lease liability
    		                   2,785,000 3,943,000 5,075,000 5,030,000 4,616,000 4,577,000 4,538,000 4,499,000                                                       
      issued and outstanding: 71,015,183 shares at december 31, 2020 and 59,172,124 shares at december 31, 2019
    		                   70,000                                                              
      long-term lease liability
    		                     591,000 1,774,000 2,195,000 3,257,000 4,294,000 5,272,000                                                       
      revenues:
    		                                                                                 
      research and development revenues
    		                      3,825,000                                                           
      total revenues
    		                      3,825,000                                                          5,867,000 
      operating expenses:
    		                                                                                 
      research and development
    		                      21,738,000                                                          9,360,000 
      general and administrative
    		                      12,449,000                                                          2,475,000 
      total operating expenses
    		                      34,187,000                                                          11,835,000 
      operating income
    		                      -30,362,000                                                          -5,968,000 
      interest expense
    		                      -4,077,000                                                           
      non-cash interest expense on liability related to the sale of future royalties
    		                      -5,689,000                                                           
      interest and other income
    		                      723,000                                                          519,000 
      net income
    		                      -39,405,000                                                          -5,932,000 
      net income per share
    		                      -660                                                           
      weighted-average number of shares used in computing net income per share — basic and diluted
    		                      59,270,000                                                           
      other comprehensive income:
    		                                                                                 
      unrealized gain on available-for-sale securities
    		                      934,000                                                           
      comprehensive loss
    		                      -38,471,000                                                           
      contract assets
    		                         575,000 2,472,000 4,554,000 5,876,000 10,375,000 18,550,000                                                   
      issued and outstanding: 59,172,124 shares at december 31, 2019 and 54,717,906 shares at december 31, 2018
    		                       59,000                                                          
      prepaid and other current assets
    		                        3,920,000 2,515,000 3,141,000 2,158,000 1,927,000 1,677,000 2,298,000 4,292,000 4,420,000 4,945,000 3,557,000 2,360,000 2,575,000 6,254,000 2,696,000 1,653,000 2,483,000 2,713,000 1,972,000 1,257,000 1,804,000 2,009,000 1,592,000 1,605,000 1,679,000 1,967,000 1,739,000 2,423,000 3,159,000 2,482,000 2,058,000 2,103,000 2,170,000 2,865,000 3,019,000 1,777,000 2,349,000 1,613,000 2,010,000 1,840,000 1,189,000 2,001,000 2,337,000 1,735,000 2,007,000 2,356,000 1,754,000 2,498,000 2,438,000 1,645,000 1,925,000 1,768,000 2,572,000 2,419,000 2,603,000   
      long-term debt
    		                        44,762,000 44,473,000 36,382,000 39,806,000 38,127,000 30,662,000 31,954,000 31,777,000 20,471,000 22,844,000 25,195,000 27,381,000 29,742,000 29,604,000 29,466,000 14,639,000                                          
      other long-term liabilities
    		                           771,000 873,000 974,000 1,035,000 1,097,000  2,000                                                
      deferred revenue, current
    		                              4,506,000 9,572,000 9,570,000 7,942,000 10,974,000 8,060,000 10,497,000 13,559,000 15,911,000 20,858,000 21,367,000 20,993,000 19,942,000 17,042,000 5,284,000 8,984,000 10,396,000 14,701,000 33,322,000 25,529,000                                
      deferred revenue, non-current
    		                               15,000,000 15,872,000 15,067,000 15,000,000 15,000,000 15,635,000 1,275,000 851,000  4,346,000 8,293,000 12,211,000 16,558,000 52,000  772,000 1,500,000 2,696,000 8,000,000                                
      issued and outstanding: 54,717,906 shares at december 31, 2018 and 53,960,832 shares at december 31, 2017
    		                           55,000                                                      
      contract liabilities
    		                             8,132,000 15,836,000                                                   
      authorized: 163,000,000
    		                                                                                 
      issued and outstanding: 53,960,832 shares at december 31, 2017 and 40,646,595 shares at december 31, 2016
    		                               54,000                                                  
      authorized: 10,000,000 shares;
    		                                                                                 
      issued and outstanding: series a convertible preferred stock — zero shares at september 30, 2017 and december 31, 2016
    		                                                                                 
      authorized: 163,000,000 shares;
    		                                                                                 
      issued and outstanding: 53,862,617 shares at september 30, 2017 and 40,646,595 shares at december 31, 2016
    		                                54,000                                                 
      issued and outstanding: series a convertible preferred stock — zero shares at june 30, 2017 and december 31, 2016
    		                                                                                 
      issued and outstanding: 53,457,091 shares at june 30, 2017 and 40,646,595 shares at december 31, 2016
    		                                 53,000                                                
      related party accounts receivable
    		                                  910,000 24,000 67,000,000 26,000  12,000 47,000 4,000 970,000 46,646,000    5,000   328,000 4,000  3,000 83,000 14,000 116,000 27,000 34,000 262,000 211,000 11,000 4,544,000 522,000 7,000 69,000 60,000 58,000 130,000 65,000 133,000 63,000 71,000 50,000 576,000 984,000 211,000 131,000 53,000  204,000 
      short-term portion of deferred rent and interest payable
    		                                  452,000 415,000 386,000 364,000 348,000                                           
      long-term portion of deferred rent
    		                                  72,000 142,000 209,000 264,000 312,000 359,000 407,000 440,000 466,000 491,000 517,000 529,000 535,000 542,000 548,000 520,000 441,000 361,000 153,000 111,000 57,000 3,000                          
      issued and outstanding: series a convertible preferred stock — zero shares at march 31, 2017 and december 31, 2016
    		                                                                                 
      issued and outstanding: 43,417,342 shares at march 31, 2017 and 40,646,595 shares at december 31, 2016
    		                                  43,000                                               
      issued and outstanding: series a convertible preferred stock — zero shares at december 31, 2016 and december 31, 2015
    		                                                                                 
      authorized: 163,000,000 shares at december 31, 2016 and 81,500,000 shares at december 31, 2015;
    		                                                                                 
      issued and outstanding: 40,646,595 shares at december 31, 2016 and 39,581,692 shares at december 31, 2015
    		                                   41,000                                              
      issued and outstanding: series a convertible preferred stock — zero shares at september 30, 2016 and december 31, 2015
    		                                                                                 
      authorized: 81,500,000 shares;
    		                                                                                 
      issued and outstanding: 40,516,892 shares at september 30, 2016 and 39,581,692 shares at december 31, 2015
    		                                    41,000                                             
      issued and outstanding: series a convertible preferred stock — zero shares at june 30, 2016 and december 31, 2015
    		                                                                                 
      issued and outstanding: 39,697,508 shares at june 30, 2016 and 39,581,692 shares at december 31, 2015
    		                                     40,000                                            
      issued and outstanding: series a convertible preferred stock — zero shares at march 31, 2016 and december 31, 2015
    		                                                                                 
      issued and outstanding: 39,607,437 shares at march 31, 2016 and 39,581,692 shares at december 31, 2015
    		                                      40,000                                           
      short-term portion of deferred rent
    		                                       132,000 110,000 89,000 70,000 52,000 44,000 37,000 29,000 22,000 14,000 10,000 43,000 76,000                              
      issued and outstanding: series a convertible preferred stock — zero shares at december 31, 2015 and december 31, 2014
    		                                                                                 
      issued and outstanding: 39,581,692 shares at december 31, 2015 and 38,659,738 shares at december 31, 2014
    		                                       40,000                                          
      issued and outstanding: series a convertible preferred stock — zero shares at september 30, 2015 and december 31, 2014
    		                                                                                 
      issued and outstanding: 38,756,313 shares at september 30, 2015 and 38,659,738 shares at december 31, 2014
    		                                        39,000                                         
      issued and outstanding: series a convertible preferred stock — zero shares at june 30, 2015 and december 31, 2014
    		                                                                                 
      issued and outstanding: 38,728,921 shares at june 30, 2015 and 38,659,738 shares at december 31, 2014
    		                                         39,000                                        
      issued and outstanding: series a convertible preferred stock — zero shares at march 31, 2015 and december 31, 2014
    		                                                                                 
      issued and outstanding: 38,716,905 shares at march 31, 2015 and 38,659,738 shares at december 31, 2014
    		                                          39,000                                       
      issued and outstanding: series a convertible preferred stock — zero shares at december 31, 2014 and december 31, 2013
    		                                                                                 
      issued and outstanding: 38,659,738 shares at december 31, 2014 and 30,681,624 shares at december 31, 2013
    		                                           39,000                                      
      accounts receivable and related party receivable
    		                                            1,191,000 319,000 2,116,000                                   
      authorized: 10,000,000 shares; issued and outstanding, none
    		                                                                                 
      issued and outstanding: 36,608,781 shares at september 30, 2014 and 30,681,624 shares at december 31, 2013
    		                                            37,000                                     
      issued and outstanding: 36,608,781 shares at june 30, 2014 and 30,681,624 shares at december 31, 2013
    		                                             37,000                                    
      issued and outstanding: 36,090,071 shares at march 31, 2014 and 30,681,624 shares at december 31, 2013
    		                                              36,000                                   
      related party payables and accrued liabilities
    		                                                   150,000    12,000 11,000 11,000 11,000   10,000 10,000 10,000 15,000 10,000 6,000 22,000 36,000 76,000 115,000 216,000 268,000 390,000 649,000       
      authorized: 10,000,000 shares ; issued and outstanding:
    		                                                                                 
      series a convertible preferred stock — zero shares at december 31, 2013 and december 31, 2012
    		                                                                                 
      series b convertible preferred stock — zero shares at december 31, 2013 and 23,026 shares at december 31, 2012
    		                                                                                 
      issued and outstanding: 30,681,624 shares at december 31, 2013 and 23,742,911 shares at december 31, 2012
    		                                               31,000                                  
      issued and outstanding: series b convertible preferred stock — 0 shares at september 30, 2013 and 23,026 shares at december 31, 2012
    		                                                                                 
      issued and outstanding: 29,503,123 shares at september 30, 2013 and 23,742,911 shares at december 31, 2012
    		                                                29,000                                 
      deficit accumulated during the development stage
    		                                                -489,128,000 -476,540,000 -461,499,000 -448,880,000 -437,424,000 -427,380,000 -418,438,000 -408,510,000 -396,632,000 -385,994,000 -372,362,000 -349,037,000 -336,696,000 -323,552,000 -298,834,000 -290,633,000 -346,592,000 -325,051,000 -308,791,000 -293,427,000 -266,280,000 -254,959,000 -242,331,000 -214,693,000 -199,773,000 -185,987,000 -173,524,000 -162,443,000 -152,342,000 -141,802,000 -131,272,000 -109,237,000 -100,006,000 
      license fee receivable
    		                                                 16,000,000                                
      issued and outstanding: series b convertible preferred stock — 4,000 shares at june 30, 2013 and 23,026 shares at december 31, 2012
    		                                                                                 
      issued and outstanding: 28,685,215 shares at june 30, 2013 and 23,742,911 shares at december 31, 2012
    		                                                 29,000                                
      authorized: 10,000,000 shares; issued and outstanding:
    		                                                                                 
      series b convertible preferred stock — 19,026 shares at march 31, 2013 and 23,026 shares at december 31, 2012
    		                                                                                 
      authorized: 245,000,000 shares;
    		                                                                                 
      issued and outstanding: 146,463,469 shares at march 31, 2013 and 142,457,469 shares at december 31, 2012
    		                                                  147,000                               
      restricted cash
    		                                                      51,000 196,000 215,000 439,000 439,000 788,000 1,233,000 1,233,000 1,674,000 2,232,000 2,232,000 2,750,000 4,147,000 4,147,000 5,167,000 6,125,000 6,125,000 5,204,000 5,100,000 4,546,000 5,172,000 4,936,000 5,136,000 5,136,000 5,980,000 5,523,000 7,199,000 
      short-term portion of equipment financing lines
    		                                                       152,000 310,000 489,000 690,000 1,028,000 1,268,000 1,453,000 1,725,000 1,797,000 1,925,000 2,460,000 3,029,000 3,542,000 4,171,000 4,117,000 4,039,000 3,317,000 2,990,000 2,763,000 2,726,000 2,608,000 2,448,000 2,421,000 2,387,000 2,108,000 1,992,000 
      series a convertible preferred stock — zero shares at december 31, 2012 and 8,070 shares at december 31, 2011
    		                                                                                 
      series b convertible preferred stock — 23,026 shares at december 31, 2012 and zero shares at december 31, 2011
    		                                                                                 
      issued and outstanding: 142,457,469 shares at december 31, 2012 and 74,915,739 shares at december 31, 2011
    		                                                   143,000                              
      short-term portion of deferred revenue
    		                                                    129,000          708,000  12,297,000 12,234,000 12,234,000 12,234,000       1,400,000 2,100,000 2,800,000 4,299,000 2,800,000 2,800,000 2,800,000 
      commitments and contingencies stockholders’ equity:
    		                                                                                 
      series a convertible preferred stock — zero shares at september 30, 2012 and 8,070 shares at december 31, 2011;
    		                                                                                 
      series b convertible preferred stock — 23,026 shares at september 30, 2012 and zero shares at december 31, 2011
    		                                                                                 
      authorized: 245,000,000 shares; issued and outstanding: 142,413,069 shares at september 30, 2012 and 74,915,739 shares at december 31, 2011
    		                                                                                 
      series a convertible preferred stock — 8,070 shares at june 30, 2012 and december 31, 2011;
    		                                                                                 
      series b convertible preferred stock — 23,026 shares at june 30, 2012 and zero shares at december 31, 2011
    		                                                                                 
      authorized: 245,000,000 shares; issued and outstanding: 133,478,796 shares at june 30, 2012 and 74,915,739 shares at december 31, 2011
    		                                                                                 
      authorized: 10,000,000 shares issued and outstanding: series a convertible preferred stock — 8,070 shares at march 31, 2012 and december 31, 2011
    		                                                                                 
      authorized: 245,000,000 shares issued and outstanding: 77,512,080 shares at march 31, 2012 and 74,915,739 shares at december 31, 2011
    		                                                      78,000                           
      long-term portion of equipment financing lines
    		                                                          34,000 309,000 489,000 724,000 1,338,000 1,757,000 2,187,000 3,081,000 3,576,000 4,112,000 5,541,000 6,604,000 7,654,000 6,654,000 6,136,000 5,933,000 6,636,000 6,914,000 6,868,000 7,490,000 8,106,000 8,210,000 7,599,000 
      authorized: 10,000,000 shares in 2011 and 2010
    		                                                                                 
      issued and outstanding: series a convertible preferred stock — 8,070 shares in 2011 and zero shares in 2010
    		                                                                                 
      authorized: 245,000,000 shares in 2011 and 170,000,000 in 2010
    		                                                                                 
      issued and outstanding: 74,915,739 shares in 2011 and 66,907,600 shares in 2010
    		                                                       75,000                          
      authorized: 10,000,000 shares at september 30, 2011 and december 31, 2010
    		                                                                                 
      issued and outstanding: series a convertible preferred stock — 8,070 shares at september 30, 2011 and zero shares at december 31, 2010
    		                                                                                 
      authorized: 245,000,000 shares at september 30, 2011 and 170,000,000 shares at december 31, 2010
    		                                                                                 
      issued and outstanding: 72,279,751 shares at september 30, 2011 and 66,907,600 shares at december 31, 2010
    		                                                        72,000                         
      authorized: 10,000,000 shares at june 30, 2011 and december 31, 2010
    		                                                                                 
      issued and outstanding: series a convertible preferred stock — 8,070 shares at june 30, 2011 and zero shares at december 31, 2010
    		                                                                                 
      authorized: 170,000,000 shares at june 30, 2011 and december 31, 2010
    		                                                                                 
      issued and outstanding: 72,279,751 shares at june 30, 2011 and 66,907,600 shares at december 31, 2010
    		                                                         72,000                        
      convertible preferred stock:
    		                                                                                 
      authorized: 10,000,000 shares at march 31, 2011 and december 31, 2010 issued and outstanding: zero shares at march 31, 2011 and december 31, 2010
    		                                                                                 
      authorized: 170,000,000 shares at march 31, 2011 and december 31, 2010 issued and outstanding: 66,916,100 shares at march 31, 2011 and 66,907,600 shares at december 31, 2010
    		                                                          67,000                       
      investments in auction rate securities
    		                                                            6,698,000 15,311,000 15,782,000 17,254,000 17,306,000                 
      investment put option related to auction rate securities rights
    		                                                            777,000 2,339,000 2,368,000 2,721,000                  
      related party notes receivable
    		                                                             9,000             451,000   350,000 387,000 1,146,000 1,146,000 
      loan with ubs
    		                                                             9,873,000 10,470,000 12,287,000 12,355,000                 
      authorized: 170,000,000 shares; issued and outstanding: 64,572,009 shares at september 30, 2010 and 61,275,036 shares at december 31, 2009
    		                                                           65,000                      
      authorized: 170,000,000 shares; issued and outstanding: 64,513,092 shares at june 30, 2010 and 61,275,036 shares at december 31, 2009
    		                                                            64,000                     
      authorized: 170,000,000 shares; issued and outstanding: 62,479,802 shares at march 31, 2010 and 61,275,036 shares at december 31, 2009
    		                                                             62,000                    
      related party notes receivable — short-term portion
    		                                                              9,000 40,000 40,000 77,000 77,000 177,000 127,000 127,000 226,000 160,000 160,000 151,000 151,000 339,000 398,000 650,000 713,000   
      assets held-for-sale
    		                                                              178,000 178,000 283,000 294,000                
      related party notes receivable — long-term portion
    		                                                                9,000 9,000 39,000 49,000 186,000 216,000 226,000 412,000 442,000 451,000        
      long-term portion of deferred revenue
    		                                                                9,122,000 15,191,000 18,250,000 21,308,000 27,425,000 30,483,000 33,542,000       700,000 1,400,000 2,800,000 3,500,000 
      authorized: 170,000,000 shares; issued and outstanding: 60,908,591 shares at september 30, 2009 and 49,939,069 shares at december 31, 2008
    		                                                              61,000                   
      authorized: 170,000,000 shares; issued and outstanding: 60,790,925 shares at june 30, 2009 and 49,939,069 shares at december 31, 2008
    		                                                               61,000                  
      investment in put option
    		                                                                2,719,000                 
      authorized: 170,000,000 shares; issued and outstanding:
    		                                                                                 
      53,560,417 shares at march 31, 2009 and 49,939,069 shares at december 31, 2008
    		                                                                54,000                 
      deferred stock-based compensation
    		                                                                 -62,000 -124,000 -187,000 -476,000 -627,000 -786,000 -1,410,000 -1,752,000 -2,073,000 -2,452,000 -2,786,000 -3,186,000 -3,552,000 -4,251,000 -5,249,000 -4,993,000 
      convertible preferred stock, 0.001 par value:
    		                                                                                 
      authorized: 120,000,000 shares; issued and outstanding: 37,793,573 shares in 2006 and 29,710,895 shares in 2005
    		                                                                       38,000          
      authorized: 120,000,000 shares; issued and outstanding: 36,613,565 shares in 2006 and 29,710,895 shares in 2005
    		                                                                        37,000         
      authorized: 120,000,000 shares; issued and outstanding: 35,595,682 shares in 2006 and 29,710,895 shares in 2005
    		                                                                         36,000        
      liabilities, convertible preferred stock and stockholders’ equity
    		                                                                                 
      commitments
    		                                                                                 
      authorized: 10,000,000 shares
    		                                                                                 
      issued and outstanding: none in 2005 and 2004
    		                                                                                 
      authorized: 120,000,000 shares
    		                                                                                 
      issued and outstanding: 29,710,895 shares in 2005 and 28,453,173 shares in 2004
    		                                                                          30,000       
      total liabilities, convertible preferred stock and stockholders’ equity
    		                                                                          91,461,000     149,503,000  
      related party notes receivable— long-term portion
    		                                                                           572,000 602,000     
      related party accrued liabilities
    		                                                                           408,000 461,000 345,000 96,000 716,000  
      authorized: 120,000,000 shares; issued and outstanding: 28,660,743 shares in 2005 and 28,453,173 shares in 2004
    		                                                                           29,000      
      authorized: 120,000,000 shares; issued and outstanding: 28,621,634 shares in 2005 and 28,453,173 shares in 2004
    		                                                                            29,000     
      authorized: 120,000,000 shares; issued and outstanding: 28,509,600 shares in 2005 and 28,453,173 shares in 2004
    		                                                                             29,000    
      related party receivable
    		                                                                               185,000  
      prepaids and other current assets
    		                                                                               2,660,000 3,070,000 
      convertible preferred stock, 0.001 par value
    		                                                                                 
      authorized: 37,300,000 shares
    		                                                                                 
      issued and outstanding: none in 2004 and 34,128,308 shares in 2003
    		                                                                                 
      authorized: 61,500,000 shares
    		                                                                                 
      issued and outstanding: 28,332,339 shares in 2004 and 2,307,258 shares in 2003
    		                                                                               28,000  
      liabilities, convertible preferred stock and stockholders’ deficit
    		                                                                                 
      issued and outstanding: 34,128,308 shares in 2004 and in 2003
    		                                                                                 
      stockholders’ deficit
    		                                                                                 
      issued and outstanding: 2,623,199 shares in 2004 and 2,307,258 shares in 2003
    		                                                                                3,000 
      total liabilities, convertible preferred stock and stockholders’ deficit
    		                                                                                56,169,000 
      research and development revenues from related party
    		                                                                                5,067,000 
      research and development and grant revenues
    		                                                                                100,000 
      license revenues from related party
    		                                                                                700,000 
      basic and diluted
    		                                                                                -2,560 
      weighted- average number of shares used in per share calculations:
    		                                                                                 
      includes the following stock-based compensation charges:
    		                                                                                 
    The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.