Quarterly
Annual
| Unit: USD | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-12-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-12-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-12-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 | 2013-12-31 | 2013-09-30 | 2013-06-30 | 2013-03-31 | 2012-12-31 | 2012-09-30 | 2012-06-30 | 2012-03-31 | 2011-09-30 | 2011-06-30 | 2011-03-31 | 2010-12-31 | 2010-09-30 | 2010-06-30 | 2010-03-31 | 2009-09-30 | 2008-12-31 | 2006-12-31 | 2005-12-31 | 2005-09-30 | 2005-06-30 | 2005-03-31 | 2004-12-31 | 2004-03-31 |
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assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current assets: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents | 125,138,000 | 102,745,000 | 89,819,000 | 127,665,000 | 137,289,000 | 128,588,000 | 149,750,000 | 135,551,000 | 111,800,000 | 172,377,000 | 299,942,000 | 66,329,000 | 50,243,000 | 35,346,000 | 61,862,000 | 77,617,000 | 94,688,000 | 95,430,000 | 52,381,000 | 76,190,000 | 30,560,000 | 58,523,000 | 84,477,000 | 31,269,000 | 44,948,000 | 58,141,000 | 49,650,000 | 41,625,000 | 33,894,000 | 31,165,000 | 33,121,000 | 31,062,000 | 31,060,000 | 33,623,000 | 37,976,000 | 51,536,000 | 47,865,000 | 41,789,000 | 40,744,000 | 40,435,000 | 36,450,000 | 37,048,000 | 37,953,000 | 24,248,000 | 26,780,000 | 33,974,000 | 43,618,000 | 54,877,000 | 63,175,000 | 72,220,000 | 81,460,000 | 93,032,000 | 101,628,000 | 34,899,000 | 42,627,000 | 45,909,000 | 52,230,000 | 59,201,000 | 24,578,000 | 28,976,000 | 35,385,000 | 18,548,000 | 10,716,000 | 14,716,000 | 8,906,000 | 3,816,000 | 1,412,000 | 2,826,000 | 3,501,000 | 5,930,117 | 8,993,337 |
short-term marketable securities | 296,545,000 | 239,481,000 | 232,944,000 | 255,669,000 | 243,047,000 | 344,568,000 | 261,011,000 | 232,670,000 | 243,425,000 | 190,885,000 | 165,115,000 | 365,343,000 | 346,019,000 | 334,740,000 | 283,665,000 | 145,918,000 | 266,643,000 | 274,552,000 | 320,578,000 | 364,506,000 | 398,233,000 | 346,835,000 | 222,838,000 | 244,693,000 | 186,697,000 | 143,396,000 | 137,255,000 | 165,135,000 | 161,300,000 | 128,780,000 | 92,241,000 | 57,682,000 | 44,096,000 | 32,542,000 | 14,798,000 | ||||||||||||||||||||||||||||||||||||
trade receivables, net of allowance | 69,629,000 | 64,567,000 | 61,819,000 | 53,976,000 | 59,717,000 | 53,837,000 | 61,518,000 | 41,123,000 | 34,626,000 | 32,553,000 | 32,557,000 | 31,057,000 | 29,414,000 | 28,164,000 | 27,178,000 | 27,625,000 | 26,508,000 | 27,620,000 | 22,200,000 | 26,198,000 | 21,957,000 | 22,725,000 | 26,684,000 | 19,928,000 | 22,405,000 | 19,774,000 | 19,218,000 | 17,588,000 | 19,360,000 | 28,704,000 | 17,261,000 | 15,300,000 | 11,872,000 | 9,504,000 | 9,214,000 | 9,860,000 | |||||||||||||||||||||||||||||||||||
inventory | 12,349,000 | 12,276,000 | 14,368,000 | 12,412,000 | 8,050,000 | 8,350,000 | 7,190,000 | 7,730,000 | 7,513,000 | 6,915,000 | 6,409,000 | 6,100,000 | 6,046,000 | 5,437,000 | 5,079,000 | 4,988,000 | 4,994,000 | 4,669,000 | 4,948,000 | 4,910,000 | 4,817,000 | 4,927,000 | 5,084,000 | 5,424,000 | 5,462,000 | 5,142,000 | 5,000,000 | 4,732,000 | 5,362,000 | 4,947,000 | 4,876,000 | 4,576,000 | 3,828,000 | 3,089,000 | 2,888,000 | 2,329,000 | 2,327,000 | 2,134,000 | 1,912,000 | 1,682,000 | 1,604,000 | 1,451,000 | 1,310,000 | 1,207,000 | 1,080,000 | 1,072,000 | 1,127,000 | 1,096,000 | 1,025,000 | 694,000 | 1,026,000 | 853,000 | 1,837,000 | 2,437,000 | 56,000 | ||||||||||||||||
prepaid expenses and other current assets | 37,469,000 | 24,043,000 | 39,553,000 | 21,880,000 | 18,875,000 | 25,503,000 | 23,898,000 | 27,562,000 | 20,163,000 | 15,858,000 | 15,870,000 | 16,424,000 | 20,680,000 | 15,358,000 | 10,436,000 | 10,315,000 | 9,067,000 | 8,999,000 | 9,517,000 | 6,697,000 | 7,926,000 | 5,323,000 | 5,693,000 | 6,044,000 | 7,798,000 | 6,202,000 | 5,741,000 | 7,740,000 | 4,275,000 | 3,579,000 | 3,324,000 | 2,669,000 | 3,086,000 | 2,527,000 | 1,799,000 | 1,964,000 | 1,353,000 | 1,554,000 | 1,106,000 | 642,000 | 1,180,000 | 1,241,000 | 622,000 | 1,441,000 | 1,769,000 | 2,166,000 | 1,453,000 | 910,000 | 1,004,000 | 801,000 | 572,000 | 620,000 | 800,000 | 608,000 | 102,000 | 427,000 | 455,000 | 604,000 | 418,000 | 613,000 | 621,000 | 581,000 | 686,000 | 1,270,000 | 343,000 | 425,000 | 830,000 | 1,317,000 | 797,000 | 838,114 | 347,940 |
total current assets | 541,130,000 | 443,112,000 | 438,503,000 | 471,602,000 | 466,978,000 | 560,846,000 | 503,367,000 | 458,636,000 | 431,527,000 | 432,588,000 | 533,893,000 | 499,253,000 | 452,402,000 | 419,045,000 | 388,220,000 | 266,463,000 | 401,900,000 | 411,270,000 | 409,624,000 | 478,501,000 | 463,493,000 | 438,333,000 | 344,776,000 | 307,358,000 | 267,310,000 | 232,655,000 | 216,864,000 | 236,820,000 | 224,191,000 | 197,175,000 | 150,823,000 | 124,185,000 | 93,942,000 | 81,285,000 | 66,675,000 | 65,689,000 | 59,781,000 | 54,778,000 | 50,514,000 | 48,980,000 | 45,179,000 | 44,691,000 | 44,186,000 | 30,230,000 | 32,375,000 | 39,437,000 | 48,120,000 | 58,311,000 | 66,223,000 | 74,570,000 | 84,201,000 | 95,062,000 | 104,619,000 | 38,299,000 | 42,785,000 | 46,336,000 | 52,685,000 | 59,805,000 | 24,996,000 | 29,589,000 | 36,006,000 | 19,129,000 | 11,402,000 | 19,579,000 | 9,799,000 | 29,505,000 | 30,641,000 | 33,655,000 | 33,077,000 | 38,239,247 | 9,341,277 |
strategic inventory | 12,002,000 | 7,991,000 | 1,166,000 | 3,583,000 | 7,764,000 | 8,451,000 | 7,846,000 | 8,244,000 | 8,752,000 | 8,762,000 | 10,156,000 | 10,931,000 | 11,027,000 | 11,978,000 | 13,098,000 | 12,962,000 | 13,659,000 | 14,734,000 | 15,384,000 | 16,247,000 | 12,075,000 | 11,193,000 | 11,063,000 | 11,981,000 | 11,539,000 | 12,726,000 | 10,360,000 | 11,510,000 | 7,360,000 | 5,500,000 | 2,910,000 | 3,800,000 | 1,680,000 | 3,210,000 | 3,820,000 | 2,835,000 | 2,980,000 | 1,960,000 | 2,280,000 | 2,800,000 | 2,990,000 | 3,420,000 | 3,730,000 | 4,090,000 | 4,430,000 | 4,570,000 | 4,330,000 | 4,450,000 | 4,530,000 | 4,850,000 | 3,650,000 | 3,810,000 | 640,000 | ||||||||||||||||||
operating lease right-of-use asset | 4,776,000 | 4,964,000 | 5,147,000 | 5,324,000 | 5,503,000 | 5,684,000 | 61,000 | 120,000 | 178,000 | 235,000 | 575,000 | 1,143,000 | 1,707,000 | 2,264,000 | 2,816,000 | 514,000 | 1,022,000 | 1,524,000 | 2,020,000 | 2,509,000 | 2,993,000 | 3,472,000 | 3,082,000 | 3,446,000 | 742,000 | 1,106,000 | 1,465,000 | ||||||||||||||||||||||||||||||||||||||||||||
property and equipment | 2,094,000 | 2,348,000 | 2,543,000 | 2,689,000 | 2,930,000 | 1,472,000 | 127,000 | 195,000 | 302,000 | 413,000 | 461,000 | 633,000 | 801,000 | 862,000 | 726,000 | 1,002,000 | 1,226,000 | 1,414,000 | 1,481,000 | 1,675,000 | 1,311,000 | 619,000 | 880,000 | 1,050,000 | 1,227,000 | 1,177,000 | 925,000 | 655,000 | 540,000 | 552,000 | 577,000 | 518,000 | 553,000 | 499,000 | 302,000 | 205,000 | 145,000 | 76,000 | 93,000 | 98,000 | 143,000 | 173,000 | 230,000 | 236,000 | 273,000 | 296,000 | 285,000 | 203,000 | 184,000 | 139,000 | 154,000 | 150,000 | 105,000 | 59,000 | 30,000 | 3,000 | 3,000 | 4,000 | 4,000 | 4,000 | 5,000 | 7,000 | 12,000 | 20,000 | 38,000 | 52,000 | 55,000 | 50,000 | |||
long-term marketable securities | 102,557,000 | 172,775,000 | 248,041,000 | 219,831,000 | 167,310,000 | 19,315,000 | 40,276,000 | 57,176,000 | 59,621,000 | 4,947,000 | 4,895,000 | 11,890,000 | 22,566,000 | 112,277,000 | 133,845,000 | 101,657,000 | 81,834,000 | 36,196,000 | 15,425,000 | 4,200,000 | 41,690,000 | 39,352,000 | 35,250,000 | 24,165,000 | 28,842,000 | 1,481,000 | 15,010,000 | 15,281,000 | 1,508,000 | 1,494,000 | 4,493,000 | ||||||||||||||||||||||||||||||||||||||||
other assets | 8,049,000 | 8,303,000 | 6,610,000 | 6,610,000 | 6,973,000 | 6,939,000 | 6,388,000 | 6,541,000 | 6,540,000 | 4,413,000 | 4,764,000 | 5,058,000 | 5,081,000 | 1,834,000 | 2,984,000 | 3,083,000 | 4,106,000 | 4,140,000 | 5,030,000 | 5,000,000 | 5,010,000 | 4,536,000 | 3,441,000 | 3,448,000 | 150,000 | 150,000 | 75,000 | 50,000 | 53,000 | 53,000 | 73,000 | 50,000 | 12,989,000 | 49,000 | 49,000 | 24,000 | 24,000 | 24,000 | 25,000 | 59,000 | 65,000 | 71,000 | 78,000 | 74,000 | 81,000 | 87,000 | 96,000 | 113,000 | 120,000 | 128,000 | 136,000 | 144,000 | 160,000 | 260,000 | 72,000 | 40,000 | 32,000 | 28,000 | 104,000 | 95,000 | 86,000 | 80,000 | 206,000 | 176,000 | 65,000 | 60,000 | 76,000 | 83,000 | 51,000 | 46,858 | 941,678 |
deferred tax assets | 152,999,000 | 162,229,000 | 144,445,000 | 130,914,000 | 126,799,000 | 111,848,000 | 97,870,000 | 90,605,000 | 87,102,000 | 78,214,000 | 67,999,000 | 61,465,000 | 57,342,000 | 48,491,000 | 37,713,000 | 27,455,000 | 29,641,000 | 33,741,000 | 37,025,000 | 31,603,000 | 33,818,000 | 35,470,000 | 40,562,000 | 45,677,000 | 50,804,000 | 56,700,000 | 61,681,000 | 62,659,000 | 66,126,000 | 71,102,000 | 73,583,000 | 76,703,000 | |||||||||||||||||||||||||||||||||||||||
total assets | 823,607,000 | 801,722,000 | 846,455,000 | 840,553,000 | 784,257,000 | 714,555,000 | 655,935,000 | 621,517,000 | 594,022,000 | 524,625,000 | 617,848,000 | 583,430,000 | 533,255,000 | 496,364,000 | 468,123,000 | 423,756,000 | 585,399,000 | 568,480,000 | 552,398,000 | 571,731,000 | 534,125,000 | 497,823,000 | 445,494,000 | 412,312,000 | 367,022,000 | 328,679,000 | 320,212,000 | 311,694,000 | 299,751,000 | 274,382,000 | 242,976,000 | 220,537,000 | 110,672,000 | 86,537,000 | 75,339,000 | 68,753,000 | 62,930,000 | 56,838,000 | 52,912,000 | 51,937,000 | 48,377,000 | 48,355,000 | 48,224,000 | 34,630,000 | 37,159,000 | 44,390,000 | 52,831,000 | 63,077,000 | 71,057,000 | 79,687,000 | 88,141,000 | 99,166,000 | 105,524,000 | 38,618,000 | 42,887,000 | 46,379,000 | 52,720,000 | 59,837,000 | 25,104,000 | 29,688,000 | 36,097,000 | 19,216,000 | 11,620,000 | 19,775,000 | 9,902,000 | 30,156,000 | 34,321,000 | 38,135,000 | 41,929,000 | 47,771,628 | 10,282,955 |
liabilities and stockholders’ equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current liabilities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts payable | 34,446,000 | 23,525,000 | 27,947,000 | 15,376,000 | 18,584,000 | 19,484,000 | 12,557,000 | 17,396,000 | 16,710,000 | 7,976,000 | 11,216,000 | 11,976,000 | 8,178,000 | 8,246,000 | 9,269,000 | 6,908,000 | 6,558,000 | 9,216,000 | 6,969,000 | 10,554,000 | 6,510,000 | 6,304,000 | 4,976,000 | 7,537,000 | 5,937,000 | 7,026,000 | 9,330,000 | 8,266,000 | 13,922,000 | 6,365,000 | 7,850,000 | 8,579,000 | 6,226,000 | 2,082,000 | 4,253,000 | 2,290,000 | 4,309,000 | 2,081,000 | 2,082,000 | 1,325,000 | 1,740,000 | 2,360,000 | 1,036,000 | 1,886,000 | 1,960,000 | 2,595,000 | 3,666,000 | 2,381,000 | 2,337,000 | 3,033,000 | 2,263,000 | 3,804,000 | 1,574,000 | 4,235,000 | 2,084,000 | 1,066,000 | 2,291,000 | 1,865,000 | 817,000 | 1,677,000 | 1,173,000 | 1,023,000 | 892,000 | 1,304,000 | 916,000 | 549,000 | 833,000 | 125,000 | 285,000 | 549,516 | 935,788 |
accrued research and development expenses | 28,322,000 | 29,049,000 | 25,260,000 | 33,868,000 | 27,736,000 | 21,972,000 | 24,825,000 | 21,330,000 | 21,305,000 | 18,607,000 | 13,981,000 | 14,573,000 | 13,771,000 | 13,803,000 | 13,051,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued and other liabilities | 108,447,000 | 91,073,000 | 88,875,000 | 90,700,000 | 79,464,000 | 59,250,000 | 59,744,000 | 51,628,000 | 69,633,000 | 52,179,000 | 39,093,000 | 30,799,000 | 29,412,000 | 24,744,000 | 32,660,000 | 27,665,000 | 24,309,000 | 21,514,000 | 17,999,000 | 21,186,000 | 18,972,000 | 22,631,000 | 19,590,000 | 23,269,000 | 21,568,000 | 16,437,000 | |||||||||||||||||||||||||||||||||||||||||||||
short-term operating lease liability | 1,050,000 | 1,017,000 | 984,000 | 829,000 | 432,000 | 44,000 | 76,000 | 151,000 | 225,000 | 297,000 | 575,000 | 1,143,000 | 1,707,000 | 2,264,000 | 2,264,000 | 526,000 | 1,046,000 | 1,559,000 | 2,067,000 | 2,050,000 | 2,034,000 | 2,019,000 | 1,571,000 | 1,558,000 | |||||||||||||||||||||||||||||||||||||||||||||||
total current liabilities | 172,265,000 | 144,664,000 | 143,066,000 | 140,773,000 | 126,216,000 | 100,750,000 | 97,202,000 | 104,505,000 | 121,873,000 | 93,059,000 | 78,865,000 | 72,491,000 | 53,068,000 | 49,057,000 | 57,244,000 | 47,541,000 | 44,757,000 | 45,402,000 | 40,601,000 | 47,494,000 | 43,048,000 | 42,243,000 | 34,075,000 | 38,841,000 | 32,396,000 | 30,381,000 | 34,218,000 | 35,573,000 | 40,206,000 | 30,873,000 | 27,749,000 | 29,569,000 | 24,370,000 | 20,392,000 | 25,759,000 | 27,374,000 | 31,683,000 | 27,434,000 | 24,025,000 | 20,876,000 | 18,767,000 | 17,430,000 | 15,526,000 | 13,555,000 | 12,486,000 | 13,302,000 | 15,242,000 | 12,738,000 | 10,142,000 | 9,079,000 | 8,243,000 | 8,359,000 | 5,548,000 | 5,816,000 | 3,570,000 | 2,713,000 | 3,856,000 | 3,196,000 | 3,860,000 | 2,993,000 | 2,859,000 | 2,143,000 | 2,358,000 | 2,862,000 | 3,513,000 | 3,521,000 | 2,656,000 | 1,503,000 | 1,261,000 | 1,824,041 | 1,529,567 |
long-term operating lease liability | 5,308,000 | 5,588,000 | 5,851,000 | 6,107,000 | 6,359,000 | 5,625,000 | 552,000 | 501,000 | 997,000 | 1,486,000 | 1,541,000 | 1,903,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term accrued income taxes payable | 14,132,000 | 15,677,000 | 14,253,000 | 14,084,000 | 12,847,000 | 11,937,000 | 10,869,000 | 10,307,000 | 10,470,000 | 9,952,000 | 9,399,000 | 9,097,000 | 6,823,000 | 4,981,000 | 2,516,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities | 191,705,000 | 165,929,000 | 163,170,000 | 160,964,000 | 145,422,000 | 118,312,000 | 108,071,000 | 114,812,000 | 132,343,000 | 103,011,000 | 88,264,000 | 81,588,000 | 59,891,000 | 54,038,000 | 60,312,000 | 47,950,000 | 45,170,000 | 45,805,000 | 41,596,000 | 48,393,000 | 44,445,000 | 44,125,000 | 36,005,000 | 41,130,000 | 32,646,000 | 30,626,000 | 34,457,000 | 35,812,000 | 2,868,000 | 3,542,000 | 3,563,000 | 2,701,000 | 1,513,000 | 1,824,041 | 2,058,464 | ||||||||||||||||||||||||||||||||||||
commitments and contingencies | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ equity: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
common stock | 139,000 | 138,000 | 137,000 | 136,000 | 135,000 | 134,000 | 133,000 | 133,000 | 133,000 | 132,000 | 131,000 | 131,000 | 130,000 | 128,000 | 128,000 | 127,000 | 126,000 | 125,000 | 124,000 | 122,000 | 121,000 | 121,000 | 120,000 | 120,000 | 119,000 | 118,000 | 118,000 | 117,000 | 116,000 | 116,000 | 115,000 | 115,000 | 114,000 | 113,000 | 113,000 | 113,000 | 111,000 | 110,000 | 110,000 | 110,000 | 109,000 | 108,000 | 108,000 | 101,000 | 101,000 | 101,000 | 101,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 89,000 | 89,000 | 84,000 | 84,000 | 84,000 | 72,000 | 72,000 | 72,000 | 63,000 | 50,000 | 50,000 | 26,000 | 23,000 | 23,000 | 23,000 | 23,000 | 9,335 | |
treasury stock | -923,290,000 | -866,931,000 | -744,692,000 | -696,173,000 | -682,177,000 | -650,763,000 | -641,059,000 | -635,078,000 | -631,788,000 | -614,074,000 | -462,507,000 | -456,148,000 | -453,001,000 | -426,814,000 | -417,448,000 | -410,411,000 | -194,304,000 | -164,263,000 | -131,855,000 | -75,795,000 | -63,969,000 | -63,814,000 | -62,979,000 | -62,704,000 | -59,732,000 | -59,732,000 | -42,312,000 | -23,657,000 | -8,904,000 | ||||||||||||||||||||||||||||||||||||||||||
additional paid-in capital | 933,613,000 | 900,864,000 | 862,866,000 | 832,108,000 | 806,317,000 | 781,012,000 | 758,244,000 | 738,515,000 | 722,397,000 | 695,718,000 | 679,848,000 | 662,342,000 | 648,831,000 | 625,976,000 | 608,717,000 | 591,349,000 | 571,377,000 | 554,154,000 | 536,363,000 | 516,140,000 | 496,489,000 | 481,714,000 | 465,528,000 | 457,060,000 | 446,611,000 | 436,622,000 | 427,317,000 | 417,228,000 | 408,154,000 | 401,011,000 | 390,951,000 | 384,074,000 | 377,678,000 | 371,282,000 | 367,359,000 | 363,534,000 | 358,001,000 | 355,000,000 | 350,485,000 | 348,796,000 | 344,735,000 | 342,184,000 | 339,294,000 | 320,511,000 | 318,687,000 | 317,449,000 | 315,817,000 | 313,534,000 | 312,166,000 | 310,858,000 | 309,593,000 | 308,283,000 | 307,033,000 | 259,901,000 | 258,820,000 | 242,209,000 | 240,973,000 | 239,921,000 | 197,473,000 | 195,831,000 | 195,269,000 | 173,418,000 | 154,381,000 | 153,031,000 | 105,125,000 | 101,014,000 | 101,027,000 | 101,006,000 | 101,334,000 | 101,360,621 | 10,428,765 |
accumulated other comprehensive income | 2,341,000 | 2,291,000 | 692,000 | -217,000 | 1,571,000 | 84,000 | 258,000 | 609,000 | 45,000 | 115,000 | 215,000 | 249,000 | 577,000 | 840,000 | 310,000 | -1,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
retained earnings | 619,099,000 | 599,431,000 | 564,282,000 | 543,735,000 | 512,989,000 | 465,776,000 | 430,288,000 | 402,526,000 | 371,171,000 | 339,793,000 | 312,265,000 | 296,386,000 | 279,785,000 | 245,177,000 | 217,765,000 | 194,968,000 | 162,915,000 | 132,444,000 | 105,921,000 | 82,456,000 | 56,462,000 | 34,837,000 | 6,510,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
total stockholders’ equity | 631,902,000 | 635,793,000 | 683,285,000 | 679,589,000 | 638,835,000 | 596,243,000 | 547,864,000 | 506,705,000 | 461,679,000 | 421,614,000 | 529,584,000 | 501,842,000 | 473,364,000 | 442,326,000 | 407,811,000 | 375,806,000 | 540,229,000 | 522,675,000 | 510,802,000 | 523,338,000 | 489,680,000 | 453,698,000 | 409,489,000 | 371,182,000 | 334,376,000 | 298,053,000 | 285,755,000 | 275,882,000 | 259,545,000 | 243,509,000 | 215,227,000 | 190,968,000 | 86,302,000 | 66,145,000 | 49,580,000 | 41,379,000 | 31,247,000 | 25,660,000 | 20,168,000 | 18,498,000 | 13,477,000 | 11,526,000 | 10,572,000 | -3,388,000 | -1,317,000 | 3,452,000 | 9,371,000 | 21,017,000 | 30,773,000 | 40,371,000 | 51,003,000 | 61,777,000 | 71,651,000 | 32,802,000 | 39,317,000 | 43,666,000 | 48,864,000 | 56,641,000 | 21,244,000 | 26,695,000 | 33,238,000 | 17,073,000 | 9,262,000 | 16,907,000 | 6,360,000 | 26,593,000 | 31,620,000 | 36,622,000 | 40,668,000 | 45,947,587 | -33,491,483 |
total liabilities and stockholders’ equity | 823,607,000 | 801,722,000 | 846,455,000 | 840,553,000 | 784,257,000 | 714,555,000 | 655,935,000 | 621,517,000 | 594,022,000 | 524,625,000 | 617,848,000 | 583,430,000 | 533,255,000 | 496,364,000 | 468,123,000 | 423,756,000 | 585,399,000 | 568,480,000 | 552,398,000 | 571,731,000 | 534,125,000 | 497,823,000 | 445,494,000 | 412,312,000 | 367,022,000 | 328,679,000 | 320,212,000 | 311,694,000 | 299,751,000 | 274,382,000 | 242,976,000 | 220,537,000 | 110,672,000 | 86,537,000 | 75,339,000 | 68,753,000 | 62,930,000 | 56,838,000 | 52,912,000 | 51,937,000 | 48,377,000 | 48,355,000 | 48,224,000 | 34,630,000 | 37,159,000 | 44,390,000 | 52,831,000 | 63,077,000 | 71,057,000 | 79,687,000 | 88,141,000 | 99,166,000 | 105,524,000 | 38,618,000 | 42,887,000 | 46,379,000 | 52,720,000 | 59,837,000 | 25,104,000 | 29,688,000 | 36,097,000 | 19,216,000 | 11,620,000 | 19,775,000 | 9,902,000 | 30,156,000 | 34,321,000 | 38,135,000 | 41,929,000 | 47,771,628 | 10,282,955 |
insurance recovery receivable related to melucci litigation | 14,000,000 | 14,000,000 | 14,000,000 | 14,000,000 | 14,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued settlement related to melucci litigation | 14,000,000 | 14,000,000 | 14,000,000 | 14,000,000 | 14,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, par value 0.001 per share, 10,000 shares authorized and no shares outstanding as of december 31, 2024 and december 31, 2023 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities and stockholders' equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, par value 0.001 per share, 10,000 shares authorized and no shares outstanding as of december 31, 2023 and december 31, 2022 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive loss | -234,000 | -153,000 | -869,000 | -2,381,000 | -2,141,000 | -1,351,000 | -70,000 | -77,000 | -127,000 | -152,000 | -75,000 | -14,000 | -17,000 | -12,000 | -108,000 | -120,000 | -106,000 | -152,000 | -61,734 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, par value 0.001 per share, 10,000 shares authorized and no shares outstanding as of december 31, 2022 and december 31, 2021 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued clinical expenses | 12,442,000 | 12,844,000 | 13,113,000 | 13,566,000 | 13,704,000 | 15,532,000 | 11,289,000 | 7,938,000 | 6,477,000 | 4,121,000 | 5,770,000 | 4,537,000 | 3,521,000 | 5,392,000 | 5,397,000 | 3,486,000 | 2,247,000 | 1,892,000 | 1,511,000 | 1,461,000 | 1,467,000 | 1,775,000 | 963,000 | 1,094,000 | 1,171,000 | 609,000 | 492,000 | 1,358,000 | 336,000 | 276,000 | 1,643,000 | 3,380,000 | 3,288,000 | 1,963,000 | 1,044,000 | 583,000 | 843,000 | 605,000 | 640,000 | 781,000 | 755,000 | 799,000 | 694,000 | 815,000 | 851,000 | 1,123,000 | 692,000 | 955,000 | 989,000 | 2,224,000 | 2,521,000 | 1,426,000 | 961,000 | 596,000 | 655,488 | 209,127 | |||||||||||||||
long-term accrued income taxes | 409,000 | 413,000 | 403,000 | 995,000 | 398,000 | 400,000 | 396,000 | 389,000 | 386,000 | 250,000 | 245,000 | 239,000 | 239,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, par value 0.001 per share, 10,000 shares authorized and no shares outstanding at december 31, 2021 and december 31, 2020 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive gain | -227,000 | 415,000 | 261,000 | 314,000 | 321,000 | 94,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, par value 0.001 per share, 10,000 shares authorized and no shares outstanding at december 31, 2020 and december 31, 2019 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, par value 0.001 per share, 10,000 shares authorized and no shares outstanding at december 31, 2019 and december 31, 2018 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated deficit | -23,555,000 | -52,936,000 | -79,276,000 | -99,462,000 | -117,736,000 | -139,744,000 | -157,491,000 | -175,687,000 | -193,146,000 | -291,476,000 | -305,233,000 | -317,880,000 | -322,268,000 | -326,865,000 | -329,450,000 | -330,427,000 | -330,408,000 | -331,367,000 | -330,766,000 | -328,830,000 | -324,000,000 | -320,105,000 | -314,098,000 | -306,547,000 | -292,617,000 | -281,493,000 | -270,587,000 | -258,690,000 | -246,606,000 | ||||||||||||||||||||||||||||||||||||||||||
operating lease liability | 770,000 | 1,148,000 | 1,521,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other accrued liabilities | 18,830,000 | 23,786,000 | 20,892,000 | 19,111,000 | 16,413,000 | 18,743,000 | 16,252,000 | 12,226,000 | 9,938,000 | 8,953,000 | 6,874,000 | 5,833,000 | 4,527,000 | 3,257,000 | 2,832,000 | 2,507,000 | 2,419,000 | 1,876,000 | 1,539,000 | 1,624,000 | 1,271,000 | 1,301,000 | 777,000 | 812,000 | 958,000 | 695,000 | 786,000 | 621,000 | 441,000 | 660,000 | 552,000 | 410,000 | 252,000 | 344,000 | 199,000 | 288,000 | 397,000 | 417,000 | 380,000 | 619,037 | 384,652 | ||||||||||||||||||||||||||||||
other receivable | 12,896,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, par value 0.001 per share, 10,000 shares authorized and no shares outstanding at december 31, 2018 and december 31, 2017 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
debt obligation - current portion | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, par value 0.001 per share, 10,000 shares authorized and no shares outstanding at december 31, 2017 and december 31, 2016 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term obligation - current portion | 4,573,000 | 10,107,000 | 14,664,000 | 18,725,000 | 18,557,000 | 16,322,000 | 13,507,000 | 12,034,000 | 10,658,000 | 9,424,000 | 8,661,000 | 7,396,000 | 6,896,000 | 5,743,000 | 2,250,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, par value 0.001 per share, 10,000 shares authorized and no shares outstanding at september 30, 2017 and december 31, 2016 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
commitments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, par value 0.001 per share, 10,000 shares authorized and no shares outstanding at june 30, 2017 and december 31, 2016 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, par value 0.001 per share, 10,000 shares authorized and no shares outstanding at march 31, 2017 and december 31, 2016 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenue | 158,000 | 79,000 | 37,000 | 55,000 | 33,000 | 50,000 | 44,000 | 29,000 | 25,000 | 55,000 | 37,000 | 76,000 | 16,000 | 21,000 | 26,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term obligation, net of current portion | 3,744,000 | 8,719,000 | 12,563,000 | 16,133,000 | 19,399,000 | 22,126,000 | 24,463,000 | 25,990,000 | 27,636,000 | 28,218,000 | 29,322,000 | 30,142,000 | 30,237,000 | 28,895,000 | 29,030,000 | 28,325,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, par value 0.001 per share, 10,000 shares authorized and no shares outstanding at december 31, 2016 and december 31, 2015 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
trade receivables | 8,236,000 | 9,301,000 | 6,752,000 | 6,221,000 | 5,945,000 | 4,951,000 | 4,301,000 | 3,334,000 | 2,746,000 | 2,225,000 | 1,922,000 | 1,428,000 | 1,019,000 | 855,000 | 1,143,000 | 557,000 | 354,000 | 355,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term obligation – current portion | 14,965,000 | 3,650,000 | 3,900,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders' equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value, 10,000 shares authorized and no shares outstanding at december 31, 2015 and 2014 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value, 10,000 shares authorized and no shares outstanding at december 31, 2014 and 2013 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, par value 0.001 per share, 10,000 shares authorized and no shares outstanding at september 30, 2014 and december 31, 2013 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, par value 0.001 per share, 10,000 shares authorized and no shares outstanding at june 30, 2014 and december 31, 2013 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, par value 0.001 per share, 10,000 shares authorized and no shares outstanding at march 31, 2014 and december 31, 2013 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value, 10,000 shares authorized and no shares outstanding at december 31, 2013 or 2012 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued compensation | 510,000 | 503,000 | 463,000 | 351,000 | 312,000 | 294,000 | 264,000 | 232,000 | 214,000 | 227,000 | 1,806,000 | 213,000 | 219,000 | 225,000 | 214,000 | 243,000 | 138,000 | 144,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term obligation—current portion | 4,500,000 | 2,650,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, par value 0.001 per share, 10,000 shares authorized and no shares outstanding at september 30, 2013 and december 31, 2012 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, par value 0.001 per share, 10,000 shares authorized and no shares outstanding at june 30, 2013 and december 31, 2012 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, par value 0.001 per share, 10,000 shares authorized and no shares outstanding at march 31, 2013 and december 31, 2012 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value, 10,000 shares authorized and no shares outstanding at december 31, 2012 or 2011 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated deficit and comprehensive loss | -235,482,000 | -227,188,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deficit accumulated during the development stage | -219,592,000 | -198,622,000 | -192,187,000 | -183,305,000 | -176,204,000 | -169,111,000 | -162,006,000 | -156,311,000 | -145,068,000 | -130,072,000 | -98,438,000 | -73,565,000 | -68,318,000 | -63,095,000 | -58,984,000 | -53,471,907 | -40,488,355 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
notes receivable from stockholders | -5,000 | -6,000 | -59,000 | -97,000 | -97,000 | -97,000 | -97,000 | -101,000 | -6,101,000 | -125,000 | -168,000 | -184,000 | -184,000 | -184,000 | -183,841 | -246,258 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
obligations under capital lease | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other liabilities | 422,000 | 316,000 | 222,000 | 295,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value, 10,000 shares authorized and no shares outstanding at december 31, 2010 or 2009 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
obligations under capital lease, short-term | 4,000 | 9,000 | 10,000 | 13,000 | 12,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
short-term investments | 3,593,000 | 550,000 | 25,264,000 | 28,399,000 | 29,512,000 | 28,779,000 | 31,471,016 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
obligations under capital lease, long-term | 6,000 | 29,000 | 42,000 | 45,000 | 10,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value, 10,000 shares authorized and no shares outstanding at december 31, 2008 or 2007 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred compensation | -228,000 | -603,000 | -808,000 | -1,022,000 | -1,369,000 | -1,718,246 | -3,194,970 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term investments | 539,000 | 3,549,000 | 4,347,000 | 8,801,000 | 9,485,523 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value, 10,000 shares authorized and no shares outstanding at december 31, 2006 or 2005 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value, 10,000 shares authorized and no shares outstanding at december 31, 2005 or 2004 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value, undesignated: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
10,000,000 shares authorized; no shares outstanding at december 31, 2004 or march 31, 2005 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible note payable | 528,897 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible preferred stock, 0.001 par value, issuable in series; 10,000,000 shares authorized; 6,768,558 shares issued and outstanding at december 31, 2003; no shares outstanding at december 31, 2004 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible preferred stock, 0.001 par value, issuable in series; 10,000,000 shares authorized and 6,768,558 shares issued and outstanding at december 31, 2003 and march 31, 2004; aggregate liquidation preference of 41,702,203 at march 31, 2004 | 41,715,974 |
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