7Baggers
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-05-13 2011-05-13 2010-05-13 2010-03-31 2009-06-30 2009-05-13 2008-12-31 2008-09-30 2008-05-13 2008-03-31 2007-03-31 2006-12-31 2006-09-30 2004-12-31 2004-09-30 2004-05-13 2004-03-31 
      
    		                                                                     
      cash flows from operating activities:
    		                                                                     
      net income
    		19,668,000 35,149,000 20,547,000 30,746,000 47,213,000 35,488,000 27,762,000 31,355,000 31,378,000 27,528,000 15,879,000 16,601,000 34,608,000 27,412,000 22,797,000 32,053,000 30,471,000 26,523,000 23,465,000 25,994,000 21,625,000 28,327,000 30,065,000 29,381,000 26,340,000 20,186,000 18,274,000 22,008,000 17,747,000 18,196,000 17,459,000 98,330,000 13,757,000 4,597,000 2,585,000 977,000 -19,000 959,000 -601,000 -1,936,000 -4,830,000 -3,895,000 -6,007,000 -7,551,000 -13,930,000 -11,124,000 -10,906,000 -11,897,000 -12,084,000 -11,124,000 -8,294,000 -7,596,000 -11,034,000 -183,305,000 -5,695,000 -156,311,000 -4,878,000 -135,522,000 -6,171,000 -5,565,000 -4,395,000 -113,941,000 -100,973,000 -3,877,000 -6,402,000 32,626,380 -4,088,765 -3,583,741 -40,488,355 
      adjustments to reconcile net income to net cash from operations:
    		                                                                     
      stock-based compensation
    		22,879,000 19,023,000 21,830,000 16,796,000 16,102,000 15,207,000 13,249,000 13,065,000 12,876,000 11,858,000 11,141,000 10,521,000 10,554,000 10,606,000 10,761,000 10,810,000 10,952,000 11,068,000 10,101,000 8,430,000 8,702,000 8,489,000 7,918,000 7,610,000 7,271,000 7,736,000 6,696,000 6,266,000 6,510,000 6,017,000 4,954,000 3,832,000 3,623,000 1,957,000 1,831,000 1,657,000 1,613,000 1,493,000 1,543,000 1,568,000 1,409,000 1,387,000 1,211,000 1,225,000 1,378,000 1,313,000 1,308,000 1,265,000 1,310,000                     
      accretion of marketable securities
    		-1,005,000 -1,312,000 -1,693,000                                                                   
      depreciation and amortization
    		289,000 286,000 285,000 281,000 318,000                                                                 
      deferred income taxes
    		9,114,000 -17,764,000 -13,705,000 -3,858,000 -15,207,000 -13,964,000 -7,162,000 -3,672,000 -8,857,000 -10,238,000 -6,726,000 -4,467,000 -8,873,000 -10,630,000 -9,935,000 2,299,000 4,108,000 3,299,000 -5,360,000 2,311,000 1,761,000 4,922,000 5,095,000 5,146,000 5,897,000 4,908,000 926,000 3,465,000 4,960,000 2,473,000 3,169,000                                       
      non-cash amortization of right-of-use asset
    		188,000 183,000 177,000    59,000 58,000 57,000 637,000 568,000 564,000 557,000 552,000 514,000 508,000 502,000 496,000 489,000 484,000 479,000 385,000 364,000                                               
      changes in operating assets and liabilities:
    		                                                                     
      trade receivables
    		-5,062,000 -2,748,000 -7,843,000 5,741,000 -5,880,000 7,681,000 -20,395,000 -6,497,000 -2,073,000 4,000 -1,500,000 -1,643,000 -1,250,000 -986,000 447,000 -1,117,000 1,112,000 -5,420,000 3,998,000 -4,241,000 768,000 3,959,000 -6,756,000 2,477,000 -2,631,000 -556,000 -1,630,000 1,772,000 9,344,000 -11,443,000 -1,961,000 -3,428,000 -2,368,000 -1,624,000 1,065,000 -2,549,000 -531,000 -276,000 -994,000 -650,000 -967,000 -588,000 -521,000 -303,000 -494,000 -409,000 -164,000 288,000 -586,000 -203,000 1,000                   
      insurance recovery receivable related to melucci litigation
    		   0 0 0 14,000,000                                                               
      inventory
    		-3,943,000 -4,626,000 605,000 -78,000 1,081,000 -1,681,000 983,000 329,000 -544,000 922,000 558,000 125,000 419,000 818,000 -163,000 789,000 797,000 992,000 866,000 -4,208,000 -720,000 86,000 1,328,000 -390,000 889,000 -2,453,000 910,000 -3,433,000 -2,275,000 -2,661,000 590,000 -1,918,000 791,000 143,000 -1,213,000 98,000 290,000 112,000 277,000 169,000 257,000 211,000 132,000 -183,000 89,000 9,000 -11,000 -868,000 -13,000 -2,186,000 -40,000 -2,381,000 -56,000                 
      prepaid expenses and other current assets
    		-13,461,000 11,293,000 -13,525,000 -3,040,000 6,594,000 -1,744,000 3,612,000     4,285,000 -5,322,000 -5,034,000 -9,000 -1,309,000 -241,000   1,229,000 -2,603,000 370,000 351,000 1,754,000 -1,596,000 -461,000 1,999,000 -3,465,000 -696,000 -275,000 -635,000 417,000 -559,000 -643,000 105,000 -320,000 -464,000 538,000 61,000 -619,000 819,000 328,000 397,000 -713,000 -543,000 94,000 -203,000 -229,000 48,000 180,000 -192,000 -506,000 38,000 -604,000 -40,000 -581,000 -646,000 -328,000 420,000 -52,000 -1,077,000 -561,000 -368,000 157,000 98,000  205,830 -530,749 -347,940 
      other assets
    		254,000   363,000 -34,000 -551,000 153,000     23,000 -3,247,000   1,023,000 34,000   10,000 -474,000 -1,095,000 7,000 -3,298,000 0 -75,000 -25,000  0 20,000 -23,000 12,939,000 -12,940,000        -10,000 1,000 -3,000 3,000 9,000  0 0 -3,000 8,000 231,000 -188,000 -40,000 -28,000 -6,000 -80,000 6,000 -180,000 -6,000 -106,000 -1,000 -63,000 -61,000 5,000 -3,000  -4,644 -178 -51,678 
      accounts payable
    		10,921,000 -4,780,000 12,929,000 -3,864,000 -113,000 6,590,000 -4,861,000 995,000 8,585,000 -3,153,000 -649,000 4,242,000 -165,000 -1,576,000 2,256,000 364,000 -2,657,000 2,189,000 -3,493,000 4,149,000 263,000 1,349,000 -2,600,000 1,689,000 -1,125,000 -2,252,000 953,000 -5,732,000 7,557,000 -1,455,000 -759,000 2,367,000 4,138,000 -2,019,000 2,228,000 -1,000 757,000 -415,000 -620,000 1,324,000 -850,000 -74,000 -635,000 -1,071,000 1,285,000 44,000 -696,000 770,000 -1,541,000 2,230,000 -2,661,000 2,151,000 -1,527,000 1,865,000 150,000 1,023,000 -901,000 1,571,000 301,000 -95,000 220,000 878,000 809,000 -1,702,000 1,353,000  350,714 136,742 493,023 
      accrued research and development expenses
    		-727,000 3,789,000 -8,608,000 6,132,000 5,764,000 -2,852,000 3,494,000 25,000 2,698,000 4,626,000 -592,000 802,000 -32,000 752,000 609,000                                                       
      accrued and other liabilities
    		17,158,000 5,945,000 -5,939,000 10,711,000 19,624,000 -1,207,000 9,114,000 -19,046,000 17,416,000 11,252,000 8,027,000 1,180,000 4,668,000 -7,916,000 4,995,000 3,341,000 2,805,000 3,550,000 -3,217,000 2,232,000 -3,687,000 3,048,000 -3,676,000 1,690,000 5,142,000                                             
      accrued settlement related to melucci litigation
    		   0 0 0 -14,000,000                                                               
      long-term accrued income taxes
    		-1,545,000 1,424,000 169,000 1,237,000 910,000 1,068,000 562,000 -163,000 518,000 553,000 302,000 2,274,000 1,842,000 2,465,000 2,107,000    597,000                                                   
      operating lease liability
    		-247,000 -230,000 -101,000 145,000 142,000 -29,000 -75,000 -74,000 -72,000 -575,000 -568,000 -564,000 -557,000 -552,000 -526,000 -520,000 -513,000 -508,000 -484,000     -344,000 -378,000 -373,000 -357,000                                           
      net cash from operating activities
    		54,481,000 43,939,000 5,128,000 59,300,000 73,829,000 41,182,000 23,756,000 5,887,000 52,909,000 42,286,000 25,957,000 33,388,000 33,648,000 18,040,000 35,247,000 49,427,000 48,704,000 44,339,000 25,422,000 35,071,000 30,444,000 53,186,000 33,269,000 48,454,000 38,427,000 25,555,000 23,681,000 21,519,000 44,505,000 15,211,000 34,430,000 24,883,000 10,925,000 4,569,000 8,935,000 1,590,000 3,297,000 4,163,000 883,000 -139,000 -1,777,000 -1,403,000 -5,929,000 -8,984,000 -11,060,000 -7,666,000 -8,602,000 -9,236,000 -11,554,000 -8,742,000 -9,229,000 -7,892,000 -10,157,000 -161,464,000 -4,517,000 -137,771,000 -6,195,000 -117,580,000 -4,494,000 -3,952,000 -5,448,000 -100,022,000 -88,211,000 -5,543,000 -5,460,000 25,498,489 -3,439,828 -3,151,331 -32,625,253 
      capex
    		0 -57,000 -104,000 -121,000 -1,635,000 0 0 0 -37,000 0 0 -31,000 -351,000 -19,000 -12,000 -65,000 -159,000 -119,000 -126,000 -431,000 -718,000 -47,000 -42,000 -135,000 -286,000 -410,000 -257,000 -113,000 -45,000 -63,000 -77,000 -29,000 -82,000 -75,000 -90,000 -7,000 -22,000 17,000 0 0 -34,000 0 -16,000 -48,000 -110,000 -40,000 -65,000 -4,000 -18,000 -58,000 -52,000 -34,000 -7,000 -61,000 0 -61,000 0 -61,000 -7,000 0 0 -54,000 -54,000 0 0 0 0 0 -53,966 
      free cash flows
    		54,481,000 43,882,000 5,024,000 59,179,000 72,194,000 41,182,000 23,756,000 5,887,000 52,872,000 42,286,000 25,957,000 33,357,000 33,297,000 18,021,000 35,235,000 49,362,000 48,545,000 44,220,000 25,296,000 34,640,000 29,726,000 53,139,000 33,227,000 48,319,000 38,141,000 25,145,000 23,424,000 21,406,000 44,460,000 15,148,000 34,353,000 24,854,000 10,843,000 4,494,000 8,845,000 1,583,000 3,275,000 4,180,000 883,000 -139,000 -1,811,000 -1,403,000 -5,945,000 -9,032,000 -11,170,000 -7,706,000 -8,667,000 -9,240,000 -11,572,000 -8,800,000 -9,281,000 -7,926,000 -10,164,000 -161,525,000 -4,517,000 -137,832,000 -6,195,000 -117,641,000 -4,501,000 -3,952,000 -5,448,000 -100,076,000 -88,265,000 -5,543,000 -5,460,000 25,498,489 -3,439,828 -3,151,331 -32,679,219 
      cash flows from investing activities:
    		                                                                     
      purchases of property and equipment
    		0 -57,000 -104,000 -121,000 -1,635,000   0 -37,000   -31,000 -351,000 -19,000 -12,000 -65,000 -159,000 -119,000 -126,000 -431,000 -718,000 -47,000 -42,000 -135,000 -286,000 -410,000 -257,000 -113,000 -45,000 -63,000 -77,000 -29,000 -82,000 -75,000 -90,000 -7,000 -22,000 17,000 0 0 -34,000 0 -16,000 -48,000 -110,000 -40,000 -65,000 -4,000 -18,000 -58,000 -52,000 -34,000 -7,000 -61,000 0 -61,000 0 -61,000 -7,000 0 0 -54,000 -54,000 0 0  0 0 -53,966 
      proceeds from sales and maturities of marketable securities
    		52,000,000 93,458,000 112,078,000                                                                   
      purchases of marketable securities
    		-37,355,000 -23,274,000 -115,145,000 -144,572,000 -223,134,000 -142,728,000 -77,876,000 -29,902,000 -210,031,000   -96,644,000 -78,851,000 -86,960,000 -92,611,000 0 -89,537,000 -95,880,000 -127,388,000 -97,020,000 -103,780,000 -170,845,000 -48,469,000 -75,704,000 -92,330,000 -60,066,000 -70,935,000 -55,799,000 -81,661,000 -44,798,000 -50,866,000 -27,419,000 -11,565,000                                     
      net cash from investing activities
    		14,645,000 70,127,000 -3,171,000 -64,360,000 -44,036,000 -60,194,000 -9,014,000  -109,570,000 -24,097,000 207,475,000 -17,241,000 -4,790,000 -41,800,000 -50,496,000 140,471,000 -25,803,000 24,742,000 -3,284,000 11,220,000 -64,273,000 -85,944,000 19,734,000 -61,989,000 -54,316,000                         -58,000 -52,000 -34,000 -7,000 -61,000 0 -61,000 1,450,000 -1,511,000 2,931,000 -6,532,000 0 -54,000 -54,000 8,196,000 4,939,000 -9,695,616 -9,771,752 -19,992,116 -53,966 
      cash flows from financing activities:
    		                                                                     
      proceeds from stock option exercises, net of issuance costs
    		2,033,000 9,235,000 1,740,000 889,000                                                                  
      proceeds from purchases under the employee stock purchase program
    		2,170,000 3,275,000 1,715,000 1,532,000 1,289,000 1,698,000 940,000                                                               
      repurchases of common stock in connection with stock repurchase program
    		-42,464,000 -103,018,000 -27,433,000                                                                   
      cash paid to satisfy statutory withholding requirement for net settlement of cashless option exercises and vesting of restricted stock grants
    		-8,152,000 -12,426,000 -15,825,000 -6,985,000 -11,651,000 -1,909,000 -1,756,000 -995,000 -5,059,000 -1,824,000 -1,228,000 -846,000                                                          
      net cash from financing activities
    		-46,413,000 -102,934,000 -39,803,000 -4,564,000 -21,092,000 -2,150,000 -543,000 766,000 -3,916,000 -145,754,000 181,000 -61,000 -13,961,000 -2,756,000 -506,000 -206,969,000 -23,643,000 -26,032,000 -45,947,000 -661,000 5,866,000 6,804,000 205,000 -144,000 2,696,000 -15,908,000 -15,289,000 -12,031,000 -8,270,000 4,044,000 1,922,000 2,567,000 -1,841,000 -823,000 -2,769,000 -538,000 -2,966,000 -195,000 -1,481,000   -1,129,000 -1,249,000 -612,000 -89,000 -592,000    204,000 76,010,000 198,000 13,156,000 220,726,000 21,354,000 156,380,000 -2,000 138,285,000 -41,000 681,000 -220,000 131,867,000 103,009,000 2,957,000 -2,000 -41,969,421 0 49,385,252 41,672,556 
      net effect of exchange rate changes on cash and cash equivalents
    		-320,000                                                                     
      net increase in cash and cash equivalents
    		  -37,846,000 -9,624,000 8,701,000 -21,162,000 14,199,000 23,751,000 -60,577,000 -127,565,000 233,613,000 16,086,000 14,897,000   -17,071,000 -742,000 43,049,000 -23,809,000 45,630,000 -27,963,000 -25,954,000 53,208,000 -13,679,000 -13,193,000 8,491,000 8,025,000 7,731,000 2,729,000 -1,956,000 2,059,000 2,000 -2,563,000 3,671,000 6,076,000 1,045,000 309,000 3,985,000 -598,000 -905,000 13,705,000     -8,298,000 -9,045,000 -9,240,000 -11,572,000 -8,596,000 66,729,000 -7,728,000 2,992,000 59,201,000 16,837,000 18,548,000 -4,747,000 19,194,000 -1,604,000 -9,803,000 -5,668,000 31,791,000 14,744,000 5,610,000 -523,000 -26,166,548 -13,211,580 26,241,805 8,993,337 
      cash and cash equivalents, at beginning of period
    		0 0 127,665,000 0 0 0 135,551,000 0 0 0 66,329,000 0 0 0 77,617,000 0 0 0 76,190,000 0 0 0 31,269,000 0 0 0 41,625,000 0 0 0 31,062,000 0 0 0 0 0 40,435,000  0 0 24,248,000  0 0 54,877,000  0 0 93,032,000  0 0 39,635,000                 
      cash and cash equivalents, at end of period
    		22,393,000 12,926,000 89,819,000 -9,624,000 8,701,000 -21,162,000 149,750,000 23,751,000 -60,577,000 -127,565,000 299,942,000 16,086,000 14,897,000 -26,516,000 61,862,000 -17,071,000 -742,000 43,049,000 52,381,000 45,630,000 -27,963,000 -25,954,000 84,477,000 -13,679,000 -13,193,000 8,491,000 49,650,000 7,731,000 2,729,000 -1,956,000 33,121,000 2,000 -2,563,000 3,671,000 6,076,000 1,045,000 40,744,000  -598,000 -905,000 37,953,000  -7,194,000 -9,644,000 43,618,000  -9,045,000 -9,240,000 81,460,000  66,729,000 -7,728,000 42,627,000 59,201,000 16,837,000 18,548,000 -4,747,000 19,194,000  -9,803,000 -5,668,000 31,791,000 14,744,000  -523,000     
      net decrease in cash and cash equivalents
    		              -15,755,000                            -7,194,000 -9,644,000 -11,259,000                         
      supplemental disclosure:
    		                                                                     
      exercise cost of shares repurchased for net settlement of cashless option exercises
    		  5,261,000    1,798,000  13,667,000 3,286,000 5,246,000 2,413,000                                                          
      adjustments to reconcile net income to net cash from operating activities:
    		                                                                     
      (accretion) of discount and amortization of premium on marketable securities
    		                                                                     
      amortization of right-of-use asset
    		   179,000 181,000                   332,000 364,000 359,000 413,000                                           
      proceeds from maturities of marketable securities
    		   80,333,000 180,733,000 82,950,000 68,862,000 47,000,000 100,498,000 64,820,000 207,475,000 79,434,000 74,412,000 45,179,000 42,127,000 90,073,000 63,893,000 120,741,000 124,230,000 108,671,000 40,225,000 84,948,000 68,245,000 13,850,000 38,300,000 59,320,000 70,825,000 54,155,000 48,200,000 23,650,000 16,650,000                                       
      repurchase of common stock in connection with tender offer
    		       0 0                                                             
      income taxes paid
    		                                                                     
      accretion of discount on marketable securities
    		    -2,866,000                                                                 
      repurchase of common stock in connection with stock repurchase program
    		    -11,710,000 -3,478,000 -476,000                                                               
      proceeds from issuance of common stock under our incentive award plan, net of issuance costs
    		     1,539,000 749,000 1,761,000 1,143,000 1,498,000 1,409,000 785,000                                                          
      (accretion) of discount on marketable securities
    		      -2,859,000                                                               
      amortization of cloud computing arrangements
    		      52,000                                                               
      depreciation and amortization of property and equipment
    		      68,000 107,000 112,000 186,000 172,000 183,000 195,000 116,000 288,000 289,000 269,000 260,000 254,000 78,000 85,000 124,000 238,000 229,000 211,000 167,000 96,000 73,000 58,000 57,000 48,000 48,000 36,000 15,000 21,000 24,000 27,000 28,000 30,000 57,000 40,000 37,000 39,000 37,000 28,000 21,000 20,000 19,000 14,000   5,000 3,000 116,000 2,000 113,000 2,000 103,000 2,000 3,000 4,000 91,000 78,000 4,000 3,000     
      other
    		                                                                     
      proceeds from sales of marketable securities
    		                                                                     
      net cash provided (used in) by investing activities
    		                                                                     
      amortization of interest income
    		        -2,753,000 -1,677,000 -1,503,000 -738,000 251,000 764,000 1,106,000                                                       
      prepaid expenses and other assets
    		        -6,432,000 363,000 848,000        -2,850,000                                                   
      recognition of right-of-use asset and lease liability
    		        0   0 0 0 2,816,000     0 0   3,035,000 0 0 1,878,000                                           
      excise tax payable
    		                                                                     
      repurchase of common stock
    		                -25,774,000 -29,170,000 -33,541,000 -9,670,000 0 0 -275,000 0 0 -17,420,000 -13,555,000 -14,753,000                                          
      proceeds from exercise of stock options, net of issuance costs
    		             550,000 1,382,000 3,047,000 4,396,000 4,748,000 4,038,000                                                   
      cash paid to satisfy statutory withholding requirement for net settlement of cashless option exercises
    		             -3,306,000 -1,888,000  -2,265,000 -1,610,000 -16,444,000                                                   
      cost of shares repurchased for net settlement of cashless option exercises
    		             6,060,000 5,149,000  2,001,000 1,659,000 6,045,000                                                   
      amortization (accretion) of interest income
    		                 1,277,000 1,194,000 899,000                                                  
      others
    		                   0 0                                                 
      accrued clinical expenses
    		               -402,000 -269,000 -453,000 -138,000 -1,828,000 4,243,000 3,351,000 1,461,000 2,356,000 -1,597,000 1,181,000 1,016,000 -1,871,000 -5,000 1,911,000 1,239,000 355,000 381,000 -308,000 812,000 -131,000 -77,000 562,000 117,000 -866,000 1,022,000 60,000 -1,367,000 -1,737,000 92,000 1,325,000 919,000 461,000 -260,000 238,000 -35,000 -141,000 137,000 694,000           -1,009,000     
      cash paid to satisfy statutory withholding requirement for the net settlement of cashless option exercises
    		                                                                     
      cost of shares repurchased for net settlement of cashless option exercise
    		                                                                     
      other receivable
    		                           0 0 20,000 12,876,000                                       
      cash paid to satisfy statutory withholding requirement for the net settlement of cashless option exercise
    		                                                                     
      adjustments to reconcile net income to net cash generated from operations:
    		                                                                     
      operating lease liabilities
    		                    -474,000 -382,000 -349,000                                               
      proceeds from issuance of common stock upon exercise of options, net of issuance costs
    		                    5,893,000 6,867,000 480,000  2,696,000 1,512,000 2,435,000  634,000 4,044,000 1,922,000                                       
      cash paid to satisfy statutory withholding requirement for net settlement of cashless option exercise
    		                    -27,000    0 0 -4,169,000                                           
      exercise price of shares tendered in net settlement of cashless option exercise
    		                    128,000    0 0 931,000                                           
      accretion of interest income
    		                     105,000 -177,000 -325,000 -360,000 -419,000 -634,000 -701,000 -474,000 -348,000 -198,000                                       
      amortization of debt financing costs
    		                               0 3,000 5,000 5,000 6,000 5,000 2,000 9,000 5,000 6,000 6,000 9,000 6,000 8,000 8,000 8,000 8,000 11,000                     
      excess tax benefits from stock option activity
    		                              54,000                                       
      payments related to debt obligation
    		                                                                     
      other accrued liabilities
    		                          -4,956,000 2,895,000 1,779,000 2,753,000 -2,383,000 1,247,000 4,026,000 2,079,000 1,041,000 1,306,000 1,270,000 425,000 325,000 88,000 543,000 337,000 -85,000 353,000 -30,000                         
      cash from investing activities
    		                          -367,000  -33,506,000 -21,211,000 -34,293,000 -27,448,000 -11,647,000 -75,000 -90,000 -7,000 -22,000 17,000 0 0 -34,000 0 -16,000 -48,000 -110,000 -40,000 -65,000 -4,000 -18,000                     
      deferred revenue
    		                                 0 0 0 -158,000 79,000 42,000 -18,000 22,000 -17,000 6,000 15,000 4,000 -30,000 18,000 -39,000 60,000 -5,000 -5,000                   
      accretion of interest expense
    		                               0 37,000 367,000 455,000 523,000 584,000 652,000 697,000 737,000 762,000 804,000 895,000 935,000 1,044,000 1,070,000 1,133,000 1,092,000 1,115,000 1,105,000                    
      deferred taxes
    		                                                                     
      proceeds from exercise of warrants, net of issuance costs
    		                                                                     
      proceeds from issuance of common stock upon exercise of options and warrants, net of issuance costs
    		                                2,772,000  1,267,000 2,731,000 75,000  1,009,000 1,322,000 17,381,000                             
      payments related to long-term obligation
    		                                -4,613,000 -4,433,000 -4,036,000 -3,269,000 -3,041,000 -2,764,000 -2,490,000 -2,088,000 -1,865,000 -1,568,000 -1,276,000 -1,017,000 -995,000                         
      adjustments to reconcile net income to net cash generated from (used in) operations:
    		                                                                     
      operating activities
    		                                                                     
      investing activities
    		                                                                     
      financing activities
    		                                                                     
      cash and cash equivalents at beginning of period
    		                                                                     
      cash and cash equivalents at end of period
    		                                                                 -16,093,445 -13,211,580 26,241,805 8,993,337 
      net cash provided (used) in financing activities
    		                                        15,516,000                             
      proceeds from issuance of common stock and warrants, net of issuance costs
    		                                           405,000 906,000                         
      proceeds from issuance of long-term obligation, net of issuance costs
    		                                                                     
      accrued compensation and other liabilities
    		                                             14,000 -28,000 -106,000 375,000                     
      proceeds from issuance of common stock and warrants, including collection of stockholder notes receivable, net of cash paid for issuance costs
    		                                                                     
      proceeds from issuance of long-term obligation, net of cash paid for issuance costs
    		                                                                     
      payment related to long-term obligation
    		                                                                     
      principal payments of obligations under capital leases
    		                                                     -59,000 -4,000 -55,000 -2,000 -45,000 -3,000 -4,000 -3,000 -33,000 -20,000 -3,000 -3,000     
      non-cash expense related to stock options
    		                                                                     
      other liabilities
    		                                                  183,000 210,000 -66,000 637,000 139,000 424,000 102,000 377,000 -933,000 1,098,000 -141,000 535,000 454,000 -104,000 123,000     
      proceeds from issuance of common stock and warrants, including collection of notes receivable, net of issuance costs
    		                                                  46,150,000 198,000 13,156,000 178,864,000 21,358,000 114,514,000 0 96,409,000            
      expense related to stock options
    		                                                                     
      expense related to stock options, net of recoveries
    		                                                    2,388,000                 
      expense related to stock issued for services or in conjunction with license agreement
    		                                                     95,000 0 95,000 0 79,000  0 4,000 75,000 75,000  0     
      expense related to stock issued below fair value
    		                                                     522,000 0 522,000 0 522,000 0 0 0 522,000 522,000 0 0  17,000 17,000 380,487 
      interest accrued on convertible promissory note
    		                                                     104,000 0 104,000 0 104,000  0 0 104,000 104,000  0     
      settlement of liquidated damages in stock
    		                                                     1,281,000 0 1,281,000 0 1,281,000            
      purchases of investments
    		                                                     -118,320,000                
      maturities of investments
    		                                                     118,320,000                
      proceeds from issuance of convertible preferred stock, net of cash paid for issuance costs
    		                                                     40,378,000 0 40,378,000 0 40,378,000 0 0 0 40,378,000 40,378,000 0 0  0 0 40,378,669 
      proceeds from issuance of convertible notes
    		                                                     1,543,000 0 1,543,000 0 1,543,000  0 0 1,543,000 1,543,000  0     
      expense related to stock options, net of reversals
    		                                                     17,159,000 502,000 14,947,000 467,000 13,088,000  398,000 408,000 11,454,000 10,230,000  377,000     
      stock-based compensation, net of recoveries
    		                                                                     
      expense related to stock issued for services
    		                                                                  0 0 45,696 
      expense related to stock issued in conjunction with license agreement
    		                                                                  0 0 14,570 
      interest accrued on convertible promissory notes
    		                                                                  0 5,208 98,561 
      purchases of short-term and long-term investments
    		                                                       -118,320,000 6,000 -118,326,000 2,938,000 -6,532,000 0 -114,726,000 -108,346,000 -4,000 -1,000     
      maturities of short-term investments
    		                                                       118,320,000 1,444,000 116,876,000          0 14,809,823 
      supplemental disclosure of cash flow information
    		                                                                     
      interest paid
    		                                                                     
      supplemental disclosure of non-cash financing activities
    		                                                                     
      conversion of convertible promissory notes and accrued interest
    		                                                                     
      —to convertible preferred stock
    		                                                                     
      —to common stock
    		                                                                     
      issuance of warrant in connection with financing agreement
    		                                                                     
      issuance of common stock in settlement of liquidated damages
    		                                                                     
      purchase of equipment under capital leases
    		                                                                     
      accrued clinical expense
    		                                                                     
      accrued clinical
    		                                                       692,000 -347,000 1,325,000 208,000 367,000 -470,000 884,000 919,000       
      proceeds from issuance of common stock and warrants, including collection of note receivable, net of cash paid for issuance costs
    		                                                                     
      proceeds from issuance of common stock, net of cash paid for issuance costs
    		                                                              60,935,000 2,917,000 1,000 -73,190 0   
      proceeds from issuance of convertible note payable
    		                                                                  0 0 462,929 
      proceeds from convertible promissory notes
    		                                                                     
      proceeds from repayment of stockholder notes
    		                                                          0 0 6,000 177,000 173,000 43,000 0     
      issuance of note receivable pursuant to sale of common stock and warrant
    		                                                                     
      sales and maturities of short-term investments
    		                                                           0 0 114,726,000        
      proceeds from issuance of common stock and warrants, net of note receivable and cash paid for issuance costs
    		                                                           685,000 -223,000 89,802,000        
      - to convertible preferred stock
    		                                                           0 0 1,111,000        
      - to common stock
    		                                                           0 0 534,000        
      issuance of note receivable for sale of common stock and warrants
    		                                                           0 0 6,000,000        
      maturities of short-term and long-term investments
    		                                                              108,346,000  4,940,000     
      depreciation
    		                                                                  0 0 53,966 
      amortization of deferred compensation, net of reversals
    		                                                                  197,322 540,132 6,662,569 
      accrued liabilities
    		                                                                  -117,285 264,255 513,848 
      proceeds from issuance of convertible notes payable
    		                                                                     
      proceeds from issuance of capital leases, net of short-term portion
    		                                                                     
      proceeds from repayment of stockholder note
    		                                                                 25,117 0 0 37,300 
      purchases of short-term investments
    		                                                                   -19,992,116 -14,809,823 
      payment to repurchase common stock
    		                                                                  0 0 -250 
      supplemental disclosure of noncash financing activities:
    		                                                                     
      issuance of preferred stock for services
    		                                                                     
      supplemental disclosure of cash flow information:
    		                                                                     
      proceeds from issuance of convertible promissory notes
    		                                                                  0 0 1,080,000 
      supplemental disclosure of non-cash financing activities:
    		                                                                     
      to common stock
    		                                                                     
      to convertible preferred stock
    		                                                                     
      payment of issuance costs related to initial public offering
    		                                                                    -360,000 
      proceeds from issuance of common stock
    		                                                                    73,908 
    The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.