7Baggers

Alpine Immune Sciences, Inc
(NASDAQ:ALPN) 

ALPN stock logo

Alpine Immune Sciences, Inc., a clinical-stage biopharmaceutical company, focuses on the discovery and development of protein-based immunotherapies for the treatment of cancer, autoimmune/inflammatory disorders, and other diseases. Its product pipeline include ALPN-101, an inducible T cell costimula...

Founded: 2007
Full Time Employees: 53
Sector: Healthcare
Industry: Biotechnology
Pharmaceuticals
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At a glance:
Bull Thesis:
Bear Thesis:
Main Competitors:
Moat:
Income Statements:
Quarterly
Annual
    Unit: USD2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 
                                        
      collaboration revenue
    		7,032,000 30,853,000 10,043,000 8,593,000 9,387,000 2,776,000 8,367,000 5,292,000 13,629,000 4,530,000 8,516,000 7,193,000 3,204,000 5,643,000 1,913,000 688,000 1,091,000 884,000 289,000 567,000    390,000 315,000 128,000 128,000          
      operating expenses:
    		                                    
      research and development
    		22,457,000 22,932,000 19,150,000 19,241,000 19,581,000 18,756,000 17,589,000 17,587,000 16,311,000 15,362,000 18,309,000 14,634,000 10,437,000 9,055,000 6,156,000 7,096,000 4,878,000 5,799,000 9,532,000 10,166,000 10,350,000 8,931,000 10,529,000 5,718,000 3,792,000 3,710,000 2,750,000 359,000 2,758,000 5,656,000 5,669,000 6,424,000 5,567,000 4,293,000 4,279,000 4,465,000 
      general and administrative
    		7,271,000 6,374,000 5,443,000 5,007,000 5,398,000 4,389,000 4,610,000 4,194,000 4,775,000 4,544,000 3,470,000 3,290,000 3,256,000 3,049,000 2,728,000 3,344,000 1,778,000 2,102,000 2,467,000 2,553,000 2,345,000 2,514,000 1,857,000 1,883,000 2,108,000 1,207,000 1,932,000 2,592,000 2,781,000 2,168,000 1,879,000 2,172,000 2,367,000 2,337,000 1,822,000 1,387,000 
      total operating expenses
    		29,728,000 29,306,000 24,593,000 24,248,000 24,979,000 23,145,000 22,199,000 21,781,000 21,086,000 19,906,000 21,779,000 17,924,000 13,693,000 12,104,000 8,884,000 10,440,000 6,656,000 7,901,000 11,999,000 12,719,000 12,695,000 11,445,000 12,386,000 8,804,000 5,900,000 4,917,000 4,682,000          
      income from operations
    		-22,696,000 1,547,000 -14,550,000 -15,655,000 -15,592,000 -20,369,000 -13,832,000 -16,489,000 -7,457,000 -15,376,000 -13,263,000 -10,731,000 -10,489,000 -6,461,000 -6,971,000 -9,752,000 -5,565,000 -7,017,000 -11,710,000 -12,152,000 -12,695,000 -11,445,000 -12,386,000 -8,414,000 -5,585,000 -4,789,000 -4,554,000 -3,815,000 -9,025,000 -7,824,000 -7,548,000 -8,596,000 -7,934,000 -6,630,000 -6,101,000 -5,852,000 
      yoy
    		45.56% -107.59% 5.19% -5.06% 109.09% 32.47% 4.29% 53.66% -28.91% 137.98% 90.26% 10.04% 88.48% -7.92% -40.47% -19.75% -56.16% -38.69% -5.46% 44.43% 127.31% 138.99% 171.98% 120.55% -38.12% -38.79% -39.67% -55.62% 13.75% 18.01% 23.72% 46.89%     
      qoq
    		-1567.10% -110.63% -7.06% 0.40% -23.45% 47.26% -16.11% 121.12% -51.50% 15.93% 23.60% 2.31% 62.34% -7.32% -28.52% 75.24% -20.69% -40.08% -3.64% -4.28% 10.92% -7.60% 47.21% 50.65% 16.62% 5.16% 19.37% -57.73% 15.35% 3.66% -12.19% 8.34% 19.67% 8.67% 4.25%  
      operating margin %
    		-Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% -Infinity% NaN% NaN% NaN% -Infinity% NaN% NaN% 
      other income:
    		                                    
      interest income
    		4,781,000 4,015,000 2,891,000 2,528,000 2,418,000 2,165,000 664,000 314,000 145,000 93,000 52,000 51,000 63,000 43,000 11,000 44,000 152,000           105,000 109,000 82,000 115,000 117,000 96,000    
      interest expense
    		   -28,000 -70,000 -87,000 -105,000 -130,000 -154,000 -178,000 -203,000 -218,000 -217,000 -215,000 -214,000 -226,000 -120,000 -49,250 -66,000 -61,000 -70,000 -76,000 -82,000 -83,000 -78,000 -76,000 -75,000          
      other
    		-3,000 501,000 -63,000 -1,000 -22,000                                
      net income
    		-17,918,000 5,960,000 -11,722,000 -13,156,000 -13,266,000 -18,864,000 -13,273,000 -18,098,000 -7,527,000 -15,167,000 -13,494,000 -11,029,000 -10,643,000 -6,342,000 -6,137,000 -9,928,000 -5,533,000 -6,140,000 -11,475,000 -11,856,000 -12,381,000             -6,563,000 -6,089,000  
      yoy
    		35.07% -131.59% -11.69% -27.31% 76.25% 24.38% -1.64% 64.09% -29.28% 139.15% 119.88% 11.09% 92.35% 3.29% -46.52% -16.26% -55.31%                    
      qoq
    		-400.64% -150.84% -10.90% -0.83% -29.68% 42.12% -26.66% 140.44% -50.37% 12.40% 22.35% 3.63% 67.82% 3.34% -38.18% 79.43% -9.89% -46.49% -3.21% -4.24%              7.78%   
      net income margin %
    		-Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% -Infinity% NaN% NaN% 
      comprehensive income:
    		                                    
      unrealized gain on investments
    		-551,000 816,000 170,000 -238,000 745,000   -304,000    21,000  1,000  -1,000 -15,000 -8,000 5,000 17,000 15,000 12,000 30,000              
      unrealized loss on foreign currency translation
    		-109,000   -5,000 -31,000   -4,000 -14,000    -15,000    -113,000 11,000 -7,000  -14,000                
      comprehensive loss
    		-18,578,000 6,897,000 -11,612,000 -13,399,000 -12,552,000 -18,316,000 -13,573,000 -18,406,000 -8,315,000 -15,455,000 -13,524,000 -11,017,000 -10,663,000 -6,248,000 -6,123,000 -9,865,000 -5,661,000 -6,137,000 -11,477,000 -11,835,000 -12,380,000   -7,857,000 -5,352,000   -3,700,000 -8,913,000 -5,937,000 -7,451,000 -8,459,000  -6,575,000 -6,074,000  
      weighted-average shares used for eps calculation
    		64,033,018,000 50,000,339,000 49,222,344,000 48,049,936,000 47,568,149,000 33,435,280,000 31,574,358,000 30,324,933,000 30,267,472,000 25,476,889,000 24,724,442,000 23,908,516,000 23,869,860,000 20,826,466,000 22,277,146,000 18,588,993,000 18,587,892,000 18,358,864,000 18,586,950,000 18,576,199,000 17,671,918,000 13,849,470,000 13,851,336,000 13,848,974,000 13,844,731,000 6,481,665 10,577,772,000          
      basic and diluted net income per share
    		-0.28 0.15 -0.24 -0.27 -0.28 -0.5 -0.42 -0.6 -0.25 -0.53 -0.55 -0.46 -0.45 -0.25 -0.28 -0.53 -0.3 -0.33 -0.62 -0.64 -0.7                
      income before taxes
    		 6,063,000 -11,722,000 -13,156,000 -13,266,000 -18,316,000 -13,273,000 -16,320,000 -7,523,000 -15,465,000 -13,414,000 -10,898,000  -6,342,000 -6,137,000 -9,934,000  -6,140,000 -11,475,000 -11,856,000 -12,381,000 -11,196,000 -12,139,000 -8,160,000 -5,358,000 -4,522,000 2,126,000          
      income tax expense
    		     -445,500  -1,778,000 -4,000                52,000 -1,000 -4,000          
      unrealized gain on foreign currency translation
    		 121,000 -60,000   64,000 7,000   -51,000 -13,000 -9,000  93,000 14,000 64,000    4,000                 
      income tax benefit
    		         298,000 -80,000 -131,000    6,000      61,000  253,000             
      other income
    		     -18,000  -15,000 -57,000     291,000 1,037,000                   3,250 12,000  
      unrealized loss on investments
    		     484,000 -307,000  -774,000 -237,000 -17,000  -5,000           50,000 -46,000 -47,000 -12,000          
      loss on sale of intangible asset
    		                       1,203,000             
      interest and other income
    		                 -1,380,000 301,000 357,000 384,000 325,000 329,000 337,000 305,000 281,000 216,000          
      bargain purchase gain
    		                         62,000 6,539,000          
      basic and diluted net income attributable to common stockholders
    		                     -11,135,000 -12,139,000 -7,907,000 -5,306,000 -4,318,000 2,122,000          
      comprehensive income
    		                     -6,329,500 -12,109,000   -869,250 2,110,000          
      basic net income per share attributable to common stockholders
    		                     -0.458 -0.88   -0.218 0.2          
      diluted net income per share attributable to common stockholders
    		                     -0.458 -0.88   -0.218 0.18          
      comprehensive loss:
    		                                    
      basic and diluted net income per share attributable to common stockholders
    		                       -0.57 -0.38            
      revenue
    		                                    
      yoy
    		                           NaN% NaN%  NaN% NaN%     
      qoq
    		                           NaN%   NaN% NaN%   NaN%  
      restructuring charges
    		                           864,000 3,486,000        
      net income attributable to common stockholders
    		                           -3,710,000 -8,916,000 -5,937,500 -7,433,000 -8,479,000  -6,563,000 -6,089,000  
      unrealized gains on marketable securities
    		                           10,000 3,000 500 -18,000 20,000     
      weighted-average shares outstanding - basic and diluted
    		                           15,656,000 15,644,000  15,504,000 15,462,000 15,462,000 9,371,000 15,451,000 4,159,000 
      net income per share
    		                           -0.24 -0.57 -0.5 -0.48 -0.55 -0.51 -0.21 -0.39 -1.41 
      includes stock-based compensation expense
    		                                    
      total stock-based compensation expense
    		                           546 2,697        
      net income and comprehensive loss
    		                                -7,838,000   -5,852,000 
      gain on extinguishment of convertible debt as a capital transaction
    		                                    
      change in unrealized gains on marketable securities
    		                                 -12,000 15,000  
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 
                                          
        assets
      		                                    
        current assets:
      		                                    
        cash and cash equivalents
      		33,015,000 43,921,000 18,981,000 34,076,000 14,465,000 13,376,000 126,625,000 24,360,000 34,889,000 67,907,000 76,099,000 18,813,000 12,629,000 34,959,000 141,075,000 88,220,000 24,446,000 16,123,000 17,395,000 15,468,000 41,437,000 10,711,000 11,473,000 3,569,000 7,446,000 8,000,000 11,982,000 27,548,000 12,929,000  16,168,000 15,416,000 16,030,000 24,991,000 57,555,000 100,521,000 
        short-term investments
      		272,646,000 283,491,000 174,472,000 169,724,000 180,460,000 224,265,000 122,237,000 143,500,000 136,980,000 94,396,000 104,529,000 72,247,000 84,185,000 70,622,000  1,998,000 11,237,000 24,397,000 29,193,000 40,097,000 22,519,000 41,592,000 50,509,000 66,376,000 69,206,000 73,240,000 75,219,000          
        accounts receivable
      		42,000 167,000 219,000 284,000 668,000 392,000 382,000 1,317,000 132,000 25,000,000  45,343,000                         
        prepaid expenses and other current assets
      		2,548,000 2,455,000 3,743,000 3,237,000 3,191,000 2,960,000 3,995,000 3,112,000 4,095,000 4,710,000 3,121,000 3,333,000 3,668,000 1,520,000 1,475,000 1,018,000 2,273,000 1,650,000 5,734,000 1,657,000 939,000 1,242,000 1,098,000 1,850,000 1,335,000 1,308,000 884,000 129,000 263,000  843,000 480,000 501,000 432,000 996,000 569,000 
        total current assets
      		308,251,000 330,034,000 197,415,000 207,321,000 198,784,000 240,993,000 253,239,000 172,289,000 176,096,000 192,013,000 183,749,000 139,736,000 100,482,000 107,101,000 142,550,000 91,236,000 38,088,000 42,302,000 52,454,000 57,222,000 64,895,000 53,545,000 63,080,000 71,795,000 77,987,000 82,548,000 88,085,000 49,626,000 52,937,000  67,030,000 74,214,000 80,713,000 87,686,000 93,647,000 101,090,000 
        restricted cash, noncurrent
      		269,000 268,000 254,000 254,000 254,000 254,000 254,000 254,000 254,000 254,000 254,000 254,000 254,000 254,000 254,000 254,000 254,000 254,000 254,000                  
        property and equipment
      		1,356,000 1,484,000 1,533,000 1,672,000 1,689,000 1,584,000 1,608,000 1,596,000 1,728,000 1,716,000 1,372,000 1,527,000 1,674,000 1,785,000 1,695,000 1,531,000 1,669,000 1,552,000 1,201,000 1,176,000 1,221,000 1,196,000 1,296,000 1,197,000 1,127,000 1,089,000 1,116,000          
        operating lease, right-of-use asset
      		7,317,000 7,510,000 7,697,000 7,877,000 8,051,000 8,219,000 8,381,000 8,539,000 8,691,000 8,837,000 8,980,000 9,118,000 9,251,000 9,401,000 9,534,000 9,674,000 9,838,000 9,985,000 10,830,000 11,303,000 603,000                
        long-term investments
      		56,453,000 40,556,000 33,502,000 35,561,000 53,170,000 35,481,000 28,016,000 33,041,000 46,948,000 52,866,000 39,064,000 9,120,000 18,316,000 25,549,000                       
        total assets
      		373,646,000 379,852,000 240,547,000 252,836,000 262,100,000 286,686,000 291,599,000 215,826,000 233,938,000 255,900,000 233,480,000 159,818,000 129,977,000 144,090,000 154,033,000 102,695,000 49,849,000 54,093,000 64,739,000 70,087,000 67,105,000 54,873,000 64,508,000 73,124,000 80,699,000 85,222,000 90,786,000 49,644,000 53,009,000 61,935,000 67,342,000 74,565,000 80,937,000 87,909,000 93,842,000 101,247,000 
        liabilities and stockholders’ equity
      		                                    
        current liabilities:
      		                                    
        accounts payable
      		4,170,000 3,593,000 3,068,000 1,645,000 1,662,000 4,286,000 3,240,000 1,812,000 1,903,000 3,349,000 1,839,000 1,393,000 466,000 582,000 742,000 548,000 468,000 1,543,000 5,778,000 2,399,000 743,000 1,716,000 440,000 750,000 528,000 193,000 1,076,000 815,000 1,278,000  1,012,000 2,110,000 1,196,000 994,000 1,552,000 3,432,000 
        accrued liabilities
      		16,891,000 21,187,000 17,788,000 13,684,000 12,030,000 14,003,000 13,744,000 12,525,000 9,203,000 9,417,000 8,653,000 4,614,000 3,953,000 5,777,000 5,065,000 3,824,000 2,551,000 5,285,000 5,825,000 5,518,000 5,371,000 4,277,000 4,314,000 585,000 586,000 382,000 642,000          
        deferred revenue, current
      		10,227,000 16,288,000 30,092,000 37,252,000 40,401,000 35,571,000 46,210,000 42,917,000 51,760,000 51,773,000 48,100,000 48,957,000 34,522,000 31,627,000 28,505,000 23,688,000                     
        operating lease liability, current
      		950,000 912,000 870,000 829,000 790,000 756,000 718,000 682,000 647,000 617,000 747,000 715,000 684,000 655,000 219,000     452,000                 
        total current liabilities
      		32,238,000 41,980,000 51,818,000 53,410,000 57,089,000 57,996,000 68,459,000 62,618,000 68,165,000 69,778,000 63,933,000 60,246,000 43,367,000 41,167,000 35,849,000 28,179,000 5,105,000 8,681,000 13,672,000 12,556,000 8,848,000 8,127,000 6,867,000 3,426,000 2,928,000 1,895,000 2,724,000 3,578,000 3,789,000  5,238,000 5,873,000 4,578,000 4,419,000 4,465,000 6,123,000 
        deferred revenue, noncurrent
      		 929,000 17,812,000 20,475,000 25,636,000 39,185,000 30,803,000 42,083,000 37,346,000 50,830,000 30,961,000 38,621,000 15,250,000 21,348,000 29,988,000 36,468,000                     
        operating lease liability, noncurrent
      		8,705,000 9,002,000 9,286,000 9,563,000 9,832,000 10,085,000 10,328,000 10,564,000 10,794,000 11,009,000 11,214,000 11,413,000 11,608,000 11,815,000 11,987,000 11,947,000 11,716,000 11,429,000 11,350,000 10,919,000                 
        total liabilities
      		40,943,000 51,911,000 78,916,000 83,448,000 92,557,000 107,266,000 109,590,000 116,290,000 118,511,000 134,997,000 110,655,000 115,987,000 76,683,000 81,932,000 86,565,000 86,467,000 24,990,000 24,619,000 29,908,000 24,666,000 10,522,000 10,282,000 9,524,000 6,577,000 6,818,000 6,305,000 7,814,000   6,499,000       
        commitments and contingencies
      		                                    
        stockholders’ equity:
      		                                    
        preferred stock, 0.001 par value per share...
      		                                    
        common stock, 0.001 par value per share...
      		66,000 60,000 49,000 49,000 48,000 46,000 44,000 30,000 30,000 30,000 29,000 24,000 24,000 24,000 24,000 19,000 19,000 19,000 19,000 19,000 19,000 14,000 14,000 14,000 14,000            
        additional paid-in capital
      		606,963,000 583,629,000 424,227,000 420,372,000 407,129,000 404,456,000 388,731,000 292,699,000 290,184,000 287,345,000 273,813,000 181,300,000 179,746,000 177,947,000 177,009,000 119,651,000 118,417,000 117,371,000 116,591,000 115,704,000 115,031,000 90,664,000 89,933,000 89,387,000 88,864,000 88,346,000 88,049,000 238,980,000 238,434,000  234,670,000 233,808,000 233,016,000 232,309,000 231,621,000 231,294,000 
        accumulated other comprehensive income
      		-263,000                            -14,000  5,000 23,000 3,000 3,000 15,000  
        accumulated deficit
      		-274,063,000 -256,145,000 -262,105,000 -250,383,000 -237,227,000 -223,961,000 -205,097,000 -191,824,000 -173,726,000 -166,199,000 -151,032,000 -137,538,000 -126,509,000 -115,866,000 -109,524,000 -103,387,000 -93,459,000 -87,926,000 -81,786,000 -70,311,000 -58,455,000 -46,074,000 -34,938,000 -22,799,000 -14,892,000 -9,384,000 -5,066,000 -192,926,000 -189,216,000 -180,300,000 -172,587,000 -165,154,000 -156,675,000 -148,837,000 -142,274,000 -136,185,000 
        total stockholders’ equity
      		332,703,000 327,941,000 161,631,000 169,388,000 169,543,000 179,420,000 182,009,000 99,536,000 115,427,000 120,903,000 122,825,000 43,831,000 53,294,000 62,158,000 67,468,000 16,228,000 24,859,000 29,474,000 34,831,000 45,421,000 56,583,000 44,591,000 54,984,000 66,547,000 73,881,000  82,972,000 46,066,000 49,220,000  62,104,000 68,692,000 76,359,000 83,490,000 89,377,000 95,124,000 
        total liabilities and stockholders’ equity
      		373,646,000 379,852,000 240,547,000 252,836,000 262,100,000 286,686,000 291,599,000 215,826,000 233,938,000 255,900,000 233,480,000 159,818,000 129,977,000 144,090,000 154,033,000 102,695,000 49,849,000 54,093,000 64,739,000 70,087,000 67,105,000       49,644,000 53,009,000  67,342,000 74,565,000 80,937,000 87,909,000 93,842,000 101,247,000 
        deferred tax asset
      		  146,000 151,000 152,000 155,000 101,000 107,000 221,000 214,000 61,000 63,000                         
        current portion of long-term debt
      		    2,206,000 3,380,000 4,547,000 4,682,000 4,652,000 4,622,000 4,594,000 4,567,000 3,742,000 2,526,000 1,318,000 119,000 1,742,000 418,000  2,079,000 2,064,000 2,048,000 2,034,000 2,018,000 1,508,000 995,000 490,000          
        treasury stock
      		                                    
        accumulated other comprehensive gain
      		 397,000        -273,000 15,000 45,000 33,000 53,000 -41,000 -55,000 -118,000 10,000 7,000 9,000                 
        accumulated other comprehensive loss
      		  -540,000 -650,000 -407,000 -1,121,000 -1,669,000 -1,369,000 -1,061,000            -12,000 -13,000 -25,000 -55,000 -105,000 -59,000 -12,000          
        long-term debt
      		       1,025,000 2,206,000 3,380,000 4,547,000 5,707,000 6,458,000 7,602,000 8,741,000 9,873,000 8,169,000 4,509,000 4,886,000 1,191,000 1,674,000 2,155,000 2,631,000 3,104,000 3,570,000 4,039,000 4,500,000          
        convertible preferred stock, 0.001 par value per share...
      		                                    
        restricted cash, current
      		                132,000 132,000 132,000                  
        deferred revenue
      		                344,000 1,435,000 2,069,000 2,108,000     240,000 277,000 405,000          
        restricted cash
      		                   386,000 386,000 132,000 132,000 132,000 132,000 132,000 132,000          
        deferred rent, current portion
      		                     86,000 79,000 73,000 66,000 48,000 44,000          
        operating lease liability
      		                    670,000                
        intangible assets
      		                        1,453,000 1,453,000 1,453,000          
        liabilities, convertible preferred stock, and stockholders’ equity
      		                                    
        deferred rent, long-term portion
      		                      26,000 47,000 67,000 66,000 81,000          
        deferred tax liability
      		                        253,000 305,000 509,000          
        total liabilities, convertible preferred stock, and stockholders’ equity
      		                     54,873,000 64,508,000 73,124,000 80,699,000  90,786,000          
        liabilities, convertible preferred stock and stockholders' equity
      		                                    
        income taxes payable
      		                          67,000          
        convertible preferred stock, 0.001 par value...
      		                                    
        stockholders' equity
      		                                    
        common stock, 0.001 par value...
      		                         14,000  16,000 16,000  16,000 15,000 15,000 15,000 15,000 15,000 
        total stockholders' equity
      		                         78,917,000    55,436,000       
        total liabilities, redeemable convertible preferred stock and stockholders' equity
      		                         85,222,000           
        liabilities, convertible preferred stock, and stockholders’ deficit
      		                                    
        convertible preferred stock, 0.0001 par value per share...
      		                                    
        stockholders’ deficit:
      		                                    
        common stock, 0.0001 par value per share...
      		                          1,000          
        marketable securities
      		                           21,949,000 39,745,000  50,019,000 58,318,000 64,182,000 62,263,000 35,096,000  
        property and equipment and other assets
      		                           18,000 72,000  312,000 351,000 224,000 223,000 195,000 157,000 
        accrued direct program expenses
      		                           8,000 87,000  2,837,000 2,742,000 2,609,000 1,555,000 1,457,000 1,682,000 
        accrued restructuring charges
      		                           2,584,000 2,251,000        
        accrued employee benefits
      		                           146,000 119,000  1,345,000 985,000 712,000 1,675,000 1,336,000 977,000 
        accrued other liabilities
      		                           25,000 54,000  44,000 36,000 61,000 195,000 120,000 32,000 
        preferred stock, 0.001 par value...
      		                                    
        cash, cash equivalents and marketable securities
      		                             61,035,000       
        working capital
      		                             55,164,000       
        convertible preferred stock
      		                                    
        convertible preferred stock with liquidation preference; 0.001 par value...
      		                                    
        stockholders’ equity
      		                                    
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 
                                         
          operating activities
        		                                 
          net income
        		-17,918,000 5,960,000 -11,722,000 -13,156,000 -13,266,000 -18,864,000 -13,273,000 -18,098,000 -7,527,000 -15,167,000 -13,494,000 -11,029,000 -10,643,000 -6,342,000 -6,137,000 -9,928,000 -5,533,000 -6,140,000 -11,475,000 -11,856,000 -12,381,000 -11,135,000 -12,139,000 -7,907,000 -5,306,000 -4,318,000 9,161,000  -7,433,000 -8,479,000 -7,838,000 -6,563,000 -6,089,000 
          adjustments to reconcile net income to net cash from operating activities:
        		                                 
          stock-based compensation expense
        		3,989,000 2,803,000 2,654,000 2,621,000 2,552,000 2,469,000 2,555,000 2,335,000 2,289,000 1,460,000 1,638,000 1,545,000 1,597,000 949,000 973,000 1,232,000 986,000 780,000           852,000 700,000 707,000 625,000 348,000 
          amortization of premium/discount on investments
        		-2,734,000 -2,561,000 -2,093,000 -1,674,000 -1,723,000 -1,334,000 43,000 259,000 332,000 304,000 192,000 192,000 218,000 163,000 -2,000 -17,000 -41,000 -86,000 -89,000 -53,000 -132,000 -216,000 -85,000           
          depreciation expense
        		147,000 148,000 146,000 142,000 140,000 145,000 148,000 156,000 148,000 138,000 155,000 162,000 165,000 159,000 140,000 144,000 135,000 124,000 115,000 -76,000 305,000 109,000 109,000 90,000 80,000         
          non-cash interest expense and other
        		                                 
          realized gain on investments
        		-18,000 0 0                               
          changes in operating assets and liabilities:
        		                                 
          accounts receivable
        		123,000 57,000 62,000 383,000 -277,000 -16,000 935,000 -1,185,000 24,868,000                         
          prepaid expenses and other current assets
        		-405,000 1,180,000 -465,000 228,000 -90,000 1,143,000 -790,000 1,035,000 613,000 -1,563,000 596,000 98,000 -2,194,000 -17,000 -360,000 1,255,000 -623,000 4,084,000 -4,077,000 -718,000 303,000 -144,000 752,000           
          operating lease, right-of-use asset
        		193,000 187,000 180,000 174,000 168,000 162,000 158,000                           
          accounts payable and accrued liabilities
        		-3,818,000 4,029,000 5,490,000 1,745,000 -4,745,000 1,980,000 2,019,000 3,409,000 -1,851,000 1,837,000 4,485,000 1,603,000 -1,955,000 785,000 1,191,000 1,538,000 -4,005,000 -4,780,000 3,767,000               
          deferred revenue
        		-6,990,000 -30,687,000 -9,823,000 -8,310,000 -8,719,000 -2,257,000 -7,987,000 -4,106,000 -13,497,000 -1,458,000 36,483,000 -7,194,000 -3,203,000 -5,518,000 -1,663,000 59,812,000 -1,091,000 -634,000 -39,000   -1,000 0 -240,000 -239,000 -128,000        
          operating lease liability
        		-259,000 -242,000 -236,000 -230,000 -220,000 -205,000 -200,000                           
          net cash from operating activities
        		-27,690,000 -18,971,000 -15,798,000 -18,091,000 -26,152,000 -16,786,000 -16,348,000 -16,069,000 5,449,000 -14,729,000 30,134,000 -14,682,000 -15,971,000 -9,349,000 -5,392,000 54,519,000 -9,694,000 -5,671,000 -10,575,000 -7,877,000 -11,223,000 -9,398,000 -7,372,000 -7,215,000 -4,431,000 -5,837,000 891,000 -5,177,000 -7,524,000 -6,547,000 -7,011,000 -5,401,000 -5,726,000 
          capital expenditures
        		-19,000 -114,000 -1,000 -279,000 -93,000 -116,000 -55,000 -215,000 -26,000 -49,000 0 -30,000 -39,000 -488,000 -60,000 -198,000 -56,000 -486,000 -135,000 -79,000 -121,000 -9,000 -208,000 -160,000 -118,000 0 0 0 -16,000 -43,000 -31,000 -46,000 -55,000 
          free cash flows
        		-27,709,000 -19,085,000 -15,799,000 -18,370,000 -26,245,000 -16,902,000 -16,403,000 -16,284,000 5,423,000 -14,778,000 30,134,000 -14,712,000 -16,010,000 -9,837,000 -5,452,000 54,321,000 -9,750,000 -6,157,000 -10,710,000 -7,956,000 -11,344,000 -9,407,000 -7,580,000 -7,375,000 -4,549,000 -5,837,000 891,000 -5,177,000 -7,540,000 -6,590,000 -7,042,000 -5,447,000 -5,781,000 
          investing activities
        		                                 
          purchase of investments
        		-75,393,000 -162,088,000 -85,538,000 -69,368,000 -34,353,000 -146,649,000 -37,955,000 -36,103,000 -46,277,000 -33,561,000 -84,446,000 -5,604,000 -9,907,000                     
          maturities of investments
        		72,850,000 49,500,000 85,004,000 98,975,000 62,796,000 38,866,000 63,800,000 42,882,000 8,500,000 29,325,000 21,931,000 26,500,000 3,400,000                     
          purchases of property and equipment
        		-19,000 -114,000 -1,000 -279,000 -93,000 -116,000 -55,000 -215,000 -26,000 -49,000 0 -30,000 -39,000 -488,000 -60,000 -198,000 -56,000 -486,000 -135,000 -79,000 -121,000 -9,000 -208,000 -160,000 -118,000    -16,000 -43,000 -31,000 -46,000 -55,000 
          net cash from investing activities
        		-2,562,000 -112,702,000 -535,000 29,328,000 28,350,000 -107,899,000 25,790,000 6,564,000 -37,803,000 -4,285,000 -62,515,000 20,866,000 -6,546,000 -96,849,000 1,843,000 9,057,000 13,130,000 4,388,000 10,863,000 -17,587,000 19,099,000 9,136,000 15,774,000 3,338,000 3,870,000 1,855,000 -46,629,000 13,149,000 8,265,000 5,841,000 -1,950,000 -27,225,000 -35,136,000 
          financing activities
        		                                 
          adjustments to offering costs
        		-8,000                                 
          repayment of debt
        		 0 0 -2,225,000 -1,200,000 -1,200,000 -1,200,000 -1,200,000 -1,200,000 -1,200,000        0 -333,000 -500,000 -500,000 -500,000            
          proceeds from exercise of stock options, net of taxes paid on vested rsus
        		1,780,000                                 
          proceeds from exercise of warrants
        		17,579,000                                 
          net cash from financing activities
        		19,351,000 156,610,000 1,201,000 8,398,000 -1,087,000 11,543,000 92,816,000 -1,020,000 -650,000 10,873,000 89,680,000 9,000 202,000 -11,000 56,390,000 2,000 5,000,000 0 1,646,000 -509,000 23,118,000 -500,000 -498,000 0 7,000 0  63,000 11,000   62,000 -2,104,000 
          effect of exchange rate on cash and cash equivalents
        		-4,000 17,000 37,000 -24,000 -22,000 -107,000 7,000                           
          net increase in cash and cash equivalents and restricted cash
        		-10,905,000 24,954,000 -15,095,000 19,611,000 1,089,000 -113,249,000    -8,192,000 57,286,000 6,184,000 -22,330,000 -106,116,000 52,855,000 63,642,000 8,323,000 -1,272,000 1,927,000 -25,969,000 30,980,000 -762,000 7,904,000 -3,877,000 -554,000 -3,982,000        
          cash and cash equivalents and restricted cash, beginning of period
        		44,189,000 0 0 0 13,630,000 0 0 0 68,161,000 0 0 0 35,213,000 0 0 0 16,509,000 0 0 0 10,843,000 0 0 0 8,132,000         
          cash and cash equivalents and restricted cash, end of period
        		33,284,000 24,954,000 -15,095,000 19,611,000 14,719,000 -113,249,000 102,265,000 -10,529,000 35,143,000 -8,192,000 57,286,000 6,184,000 12,883,000 -106,116,000 52,855,000 63,642,000 24,832,000 -1,272,000 1,927,000 -25,969,000 41,823,000 -762,000 7,904,000 -3,877,000 7,578,000         
          supplemental information
        		                                 
          cash paid for interest
        		    47,000 60,000 70,000 88,000 104,000 122,000 141,000 147,000 144,000 145,000 147,000 125,000 73,000 73,000 30,000 32,000 35,000 38,000 39,000 38,000 34,000         
          non-cash interest expense
        		 0 0 19,000 26,000 33,000 40,000 49,000 56,000 61,000 67,000 74,000 72,000 69,000 67,000 81,000 44,000 41,000 32,000 32,000 35,000 38,000 43,000 44,000 44,000 44,000        
          loss on sale of property and equipment
        		 0 9,000 0 2,000 25,000 -2,000 13,000 57,000                         
          deferred income tax
        		     -67,000 6,000   -153,000            0 0 -253,000 -52,000         
          proceeds from sale of common stock and warrants, net of offering costs
        		     12,712,000    -79,000    -13,000                    
          proceeds from issuance of common stock to amgen
        		                                 
          cash paid for income taxes
        		                                 
          proceeds from sale of common stock, net of offering costs
        		  -1,000               0 0 -20,000 23,618,000             
          proceeds from exercise of stock options
        		  1,202,000 928,000 113,000 31,000 12,000 180,000 550,000 223,000 68,000 9,000 202,000 2,000 119,000   0 2,000               
          proceeds from issuance of common stock to horizon
        		                                 
          proceeds from borrowings, net of issuance costs
        		             0 0 0 5,000,000 0                
          discount in connection with issuance of debt
        		             -1,000 0 0 335,000         0        
          net decrease in cash and cash equivalents and restricted cash
        		       -10,529,000 -33,018,000                         
          right-of-use asset
        		        146,000 143,000 138,000 133,000 150,000 134,000 140,000 171,000 147,000                 
          lease liabilities
        		        -185,000 -335,000 -167,000 -164,000 -178,000 264,000 259,000 231,000 287,000 70,000 121,000               
          effect of exchange rate on cash, cash equivalents and restricted cash
        		        -14,000 -51,000 -13,000 -9,000 -15,000 93,000 14,000 64,000 -113,000                 
          proceeds from the sale of investments
        		                                 
          recognition of right-of-use asset
        		                 -494,000 -90,000 10,874,000 883,000             
          deferred tax asset
        		                                 
          gain on sale of property and equipment
        		                                 
          loss on sale of intangible asset
        		                     0 0           
          proceeds from sale of intangible asset
        		                     0 0           
          purchase of short-term investments
        		              -96,000 43,000 -4,914,000 -5,076,000 -14,502,000 -26,508,000 -13,296,000 -9,655,000 -21,818,000 -4,353,000 -37,037,000 -16,068,000        
          maturities of short-term investments
        		              1,999,000 9,212,000 18,100,000 9,950,000 25,500,000 9,000,000 31,125,000 18,800,000 37,800,000           
          proceeds from the sale of short-term investments
        		                 0 0 0 1,391,000    41,025,000         
          bargain purchase gain
        		                         -62,000        
          cash and cash equivalents acquired in connection with merger
        		                         0        
          proceeds from sale of preferred stock
        		                         0        
          convertible preferred stock exchanged for common stock
        		                         0        
          amortization of right-of-use asset
        		                  245,000               
          deferred rent and other
        		                    -213,000 -19,000 -15,000 -13,000 19,000 -11,000        
          effect of exchange rate changes on cash, cash equivalents and restricted cash
        		                  -7,000 4,000 -14,000             
          stock-based compensation and warrant expense
        		                   682,000 754,000 731,000 544,000 523,000 511,000         
          accounts payable
        		                    -973,000 1,276,000 -310,000 222,000 335,000 -858,000 2,030,000  -1,098,000 914,000 202,000 -558,000 204,000 
          accrued liabilities
        		                    1,079,000 -37,000 3,729,000 -1,000 204,000 -341,000        
          proceeds from borrowings
        		                         0        
          proceeds from exercise of stock options and common stock warrants
        		                     0 2,000 0 7,000 0        
          reclass of preferred stock warrant liability to equity
        		                         0        
          prepaid expenses
        		                        -27,000 -345,000        
          operating activities:
        		                                 
          common stock issued for intellectual property
        		                                 
          investing activities:
        		                                 
          purchase of property and equipment
        		                                 
          proceeds from sale short-term investments
        		                                 
          financing activities:
        		                                 
          cash and cash equivalents and restricted cash at beginning of period
        		                                 
          cash and cash equivalents and restricted cash at end of period
        		                                 
          depreciation and amortization
        		                                 
          depreciation
        		                            38,000 36,000 30,000  16,000 
          gain on sales of property and equipment
        		                                 
          prepaid expenses and other
        		                            -346,000 -99,000 -69,000 564,000 -427,000 
          accrued direct program expenses
        		                            95,000 133,000 1,054,000 98,000 -225,000 
          accrued restructuring charges
        		                                 
          accrued employee benefits
        		                            360,000 273,000 -963,000 339,000 359,000 
          accrued other liabilities
        		                            8,000 -25,000 -134,000 75,000  
          proceeds from sales of property and equipment
        		                                 
          purchases of marketable securities
        		                            -13,919,000 -22,766,000 -29,469,000 -41,179,000  
          proceeds from sales and maturities of marketable securities
        		                            22,200,000 28,650,000 27,550,000   
          proceeds from employee stock purchases and stock options exercised
        		                            11,000     
          net increase in cash and cash equivalents
        		                           8,035,000 752,000   -32,564,000 -42,966,000 
          cash and cash equivalents, beginning of period
        		                            0 0 24,991,000 0 0 
          cash and cash equivalents, end of period
        		                            752,000 -614,000 16,030,000 -32,564,000 -42,966,000 
          proceeds from issuance of common stock, net of offering costs
        		                               -1,000 -2,104,000 
          supplemental disclosures of cash flow information
        		                                 
          conversion of convertible preferred stock to common stock
        		                               0 0 
          net decrease in cash and cash equivalents
        		                              -8,961,000   
          description
        		                              2,016,000   
          assets measured at fair value:
        		                                 
          money market investments
        		                              7,592,000   
          u.s. treasury securities, obligations of u.s. government agencies, corporate debt securities and reverse repurchase agreements
        		                              70,182,000   
          depreciation and loss on disposal of assets
        		                                 
          change in value of preferred stock warrant liabilities and derivative
        		                                 
          amortization of deferred financing costs and noncash interest
        		                                 
          proceeds from issuance of convertible preferred stock
        		                                 
          decrease in restricted cash
        		                                 
          proceeds from notes payable
        		                                 
          principal payment on debt
        		                                 
          conversion of convertible debt and accrued interest to convertible preferred stock
        		                                 
          loss on disposal of assets