7Baggers

ACADIA Pharmaceuticals Inc
(NASDAQ:ACAD) 

ACAD stock logo

ACADIA Pharmaceuticals Inc., a biopharmaceutical company, focuses on the development and commercialization of small molecule drugs that address unmet medical needs in central nervous system disorders. The company offers NUPLAZID (pimavanserin) for the treatment of hallucinations and delusions associ...

Founded: 1993
Full Time Employees: 580
CEO: Catherine Owen Adams  
Sector: Healthcare
Industry: Biotechnology
Pharmaceuticals
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Quarterly
Annual
    Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 
                                                                                           
      revenues
    		                                                                                       
      product sales
    		283,989,000 278,633,000 264,566,000 244,317,000 259,602,000 250,401,000 241,963,000 205,831,000 231,041,000 211,699,000 165,235,000 118,462,000 136,490,000 130,714,000 134,563,000 115,468,000 130,758,000 131,612,000 115,221,000 106,554,000 121,007,000 120,577,000 110,103,000 90,068,000 98,326,000 94,586,000 83,205,000 62,959,000 59,571,000 58,305,000 57,063,000 48,868,000 43,562,000 35,578,000 30,475,000 15,286,000 11,962,000 5,268,000 97,000                                                 
      total revenues
    		283,989,000 278,633,000 264,566,000 244,317,000 259,602,000 250,401,000 241,963,000 205,831,000 231,041,000 211,699,000 165,235,000 118,462,000 136,490,000 130,714,000 134,563,000 115,468,000 130,758,000 131,612,000 115,221,000 106,554,000 121,007,000 120,577,000 110,103,000 90,068,000 98,326,000 94,586,000 83,205,000 62,959,000 59,571,000 58,305,000 57,063,000 48,868,000 43,562,000 35,578,000 30,475,000 15,286,000 11,962,000 5,268,000 97,000                                              1,083,400 1,581,300 1,015,700 
      yoy
    		9.39% 11.27% 9.34% 18.70% 12.36% 18.28% 46.44% 73.75% 69.27% 61.96% 22.79% 2.59% 4.38% -0.68% 16.79% 8.37% 8.06% 9.15% 4.65% 18.30% 23.07% 27.48% 32.33% 43.06% 65.06% 62.23% 45.81% 28.83% 36.75% 63.88% 87.25% 219.69% 264.17% 575.36% 31317.53%                                                     
      qoq
    		1.92% 5.32% 8.29% -5.89% 3.67% 3.49% 17.55% -10.91% 9.14% 28.12% 39.48% -13.21% 4.42% -2.86% 16.54% -11.69% -0.65% 14.23% 8.13% -11.94% 0.36% 9.51% 22.24% -8.40% 3.95% 13.68% 32.16% 5.69% 2.17% 2.18% 16.77% 12.18% 22.44% 16.74% 99.37% 27.79% 127.07% 5330.93%                                               -31.49% 55.69%  
      operating expenses
    		                                                                                       
      cost of product sales
    		26,225,000 21,647,000 20,734,000 20,392,000 21,803,000 18,857,000 18,230,000 22,951,000 17,891,000 14,622,000 7,459,000 1,667,000 2,413,000 2,136,000 2,667,000 2,950,000 2,444,000 3,688,000 2,526,000 2,185,000 2,508,000 2,005,000 2,899,000 2,799,000 3,020,000 2,416,000 2,958,000 2,950,000 2,823,000 3,839,000 3,562,000 2,153,000 2,455,000 2,135,000 2,224,000 2,263,000 1,704,000 845,000 526,000                                                 
      research and development
    		84,757,000 87,829,000 77,951,000 78,265,000 100,731,000 66,606,000 76,233,000 59,679,000 66,741,000 156,963,000 58,771,000 69,144,000 75,738,000 81,336,000 75,646,000 128,855,000 66,942,000 58,565,000 56,935,000 56,973,000 62,116,000 120,083,000 64,295,000 72,636,000 57,520,000 62,622,000 67,320,000 52,923,000 48,183,000 53,112,000 46,592,000 39,276,000 43,179,000 36,421,000 34,180,000 35,409,000 30,218,000 25,813,000 20,478,000 22,775,000 20,466,000 18,729,000 18,379,000 16,295,000 18,182,000 16,952,000 13,799,000 11,668,000 7,925,000 7,254,000 7,112,000 4,430,000 4,901,000 4,400,000 4,472,000 5,021,000 4,424,000 4,158,000 4,315,000 4,412,000 4,757,000 4,965,000 5,041,000 5,815,000 7,836,000 9,215,000 11,979,000 12,554,000 12,146,000 13,397,000 16,036,000 15,171,000 17,278,000 16,909,000 11,495,000 12,261,000 10,919,000 16,099,000 12,255,000 10,126,000 10,104,300 8,064,900 6,563,100 6,115,600 6,374,900 5,923,200 5,406,600 
      selling, general and administrative
    		155,616,000 133,401,000 133,507,000 126,370,000 130,080,000 133,294,000 117,063,000 107,991,000 111,465,000 97,890,000 95,968,000 101,235,000 104,402,000 78,108,000 89,901,000 96,679,000 105,912,000 81,666,000 96,789,000 111,661,000 120,752,000 81,592,000 84,344,000 101,973,000 91,871,000 72,696,000 67,981,000 93,090,000 74,271,000 61,089,000 69,472,000 60,926,000 65,539,000 62,255,000 61,523,000 65,745,000 57,663,000 50,534,000 50,768,000                                                 
      total operating expenses
    		266,598,000 242,877,000 232,192,000 225,027,000 106,099,000 218,757,000 211,526,000 190,621,000 196,097,000 269,475,000 162,198,000 172,046,000 182,553,000 161,580,000 168,214,000 228,484,000 175,415,000 146,913,000 158,930,000 173,326,000 188,169,000 206,476,000 154,113,000 179,583,000 154,725,000 140,007,000 140,296,000 150,593,000 126,846,000 119,576,000 121,142,000 103,687,000 112,421,000 101,889,000 98,909,000 104,092,000 90,193,000 77,667,000 72,020,000 50,266,000 45,582,000 39,037,000 39,498,000 40,556,000 28,602,000 25,009,000 21,751,000 17,988,000 12,201,000 11,051,000 9,608,000 6,581,000 7,199,000 5,885,000 6,028,000 6,681,000 5,902,000 5,677,000 7,044,000 6,296,000 6,275,000 6,543,000 6,593,000 7,629,000 10,475,000 11,209,000 14,641,000 15,542,000 14,536,000 16,371,000 19,220,000 18,441,000 20,288,000 19,850,000 14,658,000 15,413,000 15,323,000 14,482,000 14,745,000 12,637,000 13,142,900 16,486,000 9,008,300 8,125,400 8,538,800 7,903,800 6,901,000 
      income from operations
    		17,391,000 35,756,000 32,374,000 19,290,000 153,503,000 31,644,000 30,437,000 15,210,000 34,944,000 -57,776,000 3,037,000 -53,584,000 -46,063,000 -30,866,000 -33,651,000 -113,016,000 -44,657,000 -15,301,000 -43,709,000 -66,772,000 -67,162,000 -85,899,000 -44,010,000 -89,515,000 -56,399,000 -45,421,000 -57,091,000 -87,634,000 -67,275,000 -61,271,000 -64,079,000 -54,819,000 -68,859,000 -66,311,000 -68,434,000 -88,806,000 -78,231,000 -72,399,000 -71,923,000 -50,262,000 -45,565,000 -38,998,000 -39,497,000 -40,552,000 -28,554,000 -24,994,000 -21,723,000 -17,958,000 -12,164,000 -10,811,000 -9,157,000 -6,164,000 -6,819,000 -2,407,000 -5,429,000 -6,231,000 -5,314,000 -5,093,000 -6,584,000 -5,861,000 29,129,000 -4,242,000 -4,296,000 -5,496,000 -8,706,000 -8,774,000 -12,821,000 -15,168,000 -14,211,000 -16,089,000 -19,043,000 -17,635,000 -18,705,000 -17,893,000 -12,603,000 -13,453,000 -13,550,000 -12,539,000 -12,864,000 -10,100,000 -10,699,900 -12,812,500 -6,493,700 -5,800,200 -7,455,400 -6,322,500 -5,885,300 
      yoy
    		-88.67% 12.99% 6.36% 26.82% 339.28% -154.77% 902.21% -128.39% -175.86% 87.18% -109.02% -52.59% 3.15% 101.73% -23.01% 69.26% -33.51% -82.19% -0.68% -25.41% 19.08% 89.12% -22.91% 2.15% -16.17% -25.87% -10.91% 59.86% -2.30% -7.60% -6.36% -38.27% -11.98% -8.41% -4.85% 76.69% 71.69% 85.65% 82.10% 23.94% 59.57% 56.03% 81.82% 125.82% 134.74% 131.19% 137.23% 191.34% 78.38% 349.15% 68.67% -1.08% 28.32% -52.74% -17.54% 6.31% -118.24% 20.06% 53.26% 6.64% -434.59% -51.65% -66.49% -63.77% -38.74% -45.47% -32.67% -13.99% -24.03% -10.08% 51.10% 31.09% 38.04% 42.70% -2.03% 33.20% 26.64% -2.13% 98.10% 74.13% 43.52% 102.65% 10.34%     
      qoq
    		-51.36% 10.45% 67.83% -87.43% 385.09% 3.97% 100.11% -56.47% -160.48% -2002.40% -105.67% 16.33% 49.24% -8.28% -70.22% 153.08% 191.86% -64.99% -34.54% -0.58% -21.81% 95.18% -50.84% 58.72% 24.17% -20.44% -34.85% 30.26% 9.80% -4.38% 16.89% -20.39% 3.84% -3.10% -22.94% 13.52% 8.06% 0.66% 43.10% 10.31% 16.84% -1.26% -2.60% 42.02% 14.24% 15.06% 20.97% 47.63% 12.52% 18.06% 48.56% -9.61% 183.30% -55.66% -12.87% 17.26% 4.34% -22.65% 12.34% -120.12% -786.68% -1.26% -21.83% -36.87% -0.78% -31.57% -15.47% 6.73% -11.67% -15.51% 7.98% -5.72% 4.54% 41.97% -6.32% -0.72% 8.06% -2.53% 27.37% -5.61% -16.49% 97.31% 11.96% -22.20% 17.92% 7.43%  
      operating margin %
    		6.12% 12.83% 12.24% 7.90% 59.13% 12.64% 12.58% 7.39% 15.12% -27.29% 1.84% -45.23% -33.75% -23.61% -25.01% -97.88% -34.15% -11.63% -37.93% -62.66% -55.50% -71.24% -39.97% -99.39% -57.36% -48.02% -68.61% -139.19% -112.93% -105.09% -112.30% -112.18% -158.07% -186.38% -224.56% -580.96% -654.00% -1374.32% -74147.42% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -688.15% -399.83% -579.43% 
      interest income
    		8,332,000 8,246,000 7,243,000 7,901,000 7,007,000 6,586,000 6,359,000 5,506,000 4,759,000 4,125,000 4,550,000 3,800,000 3,630,000 2,295,000 580,000 105,000 129,000 129,000 133,000 200,000 554,000 1,242,000 1,825,000 2,989,000 3,272,000 2,432,000 2,527,000 2,934,000 1,670,000 1,229,000 1,279,000 1,170,000 1,107,000 1,063,000 993,000 963,000 876,000 786,000 601,000 500,000 111,000 92,000 119,000 177,000 188,000 208,000 228,000 130,000 115,000 116,000 76,000 41,000 9,000 5,000 10,000 13,000 14,000 17,000 28,000 28,000 12,000 15,000 8,000 21,000 33,000 67,000 117,000 191,000 285,000 521,000 802,000 1,307,000 1,729,000 1,919,000 1,920,000 964,000 1,160,000 1,327,000 1,041,000 625,000 549,000 546,700 494,400 261,300 198,100 204,400 117,400 
      other income
    		596,000 593,000 594,000 588,000 575,000 576,000 386,000 286,000  1,508,000 -1,244,000 4,845,000 1,543,000 2,156,000 -497,000 340,000 1,623,000 383,000 178,000 145,000 265,000 -202,000 437,000 -1,497,000 491,000 747,000 -12,000 -229,000                                                            
      income before income taxes
    		26,319,000 44,595,000 40,211,000 27,779,000 161,085,000 38,806,000 37,182,000 21,002,000 39,703,000 -52,143,000 6,343,000 -44,939,000 -40,890,000 -26,415,000 -33,568,000 -112,571,000 -42,905,000 -14,789,000 -43,398,000 -66,427,000 -66,343,000 -84,859,000 -41,748,000 -88,023,000 -52,636,000 -42,242,000 -54,576,000 -84,929,000 -65,478,000 -61,762,000 -63,047,000 -53,649,000                                                        
      income tax expense
    		-247,249,000 -27,184,000 13,545,000 8,792,000 17,343,000 6,041,000 3,793,000 4,447,000 -6,094,000 13,033,000 5,229,000 -1,918,000 835,000 768,000 443,000 485,000 189,000 -332,000 473,000 21,000 417,000 -199,000 393,000    365,000 375,000 14,000 376,000 219,000 647,000                                                        
      net income
    		273,568,000 71,779,000 26,666,000 18,987,000 143,742,000 32,765,000 33,389,000 16,555,000 45,797,000 -65,176,000 1,114,000 -43,021,000 -41,725,000 -27,183,000 -34,011,000 -113,056,000 -43,094,000 -14,457,000 -43,871,000 -66,448,000 -66,760,000 -84,660,000 -42,141,000 -88,023,000 -53,036,000 -41,978,000 -54,941,000 -85,304,000 -65,492,000 -62,138,000 -63,266,000 -54,296,000 -68,871,000 -65,248,000 -67,441,000 -87,843,000 -78,696,000 -71,613,000 -71,322,000 -49,762,000 -45,784,000 -38,906,000 -39,378,000 -40,375,000 -28,366,000 -24,786,000 -21,495,000 -17,828,000 -12,049,000 -10,695,000 -9,081,000 -6,123,000 -6,810,000 -2,402,000 -5,419,000 -6,218,000 -5,300,000 -5,076,000 -6,556,000 -5,833,000 29,141,000 -4,227,000 -4,288,000 -5,487,000 -8,689,000 -8,728,000 -12,728,000 -15,001,000 -13,963,000 -15,614,000 -18,287,000 -16,380,000 -17,039,000 -16,045,000 -10,753,000 -12,554,000 -12,450,000 -11,263,000 -11,867,000 -9,467,000 -10,202,900 -12,306,100 -6,036,900 -5,589,200 -7,334,800 -6,214,500 -5,886,500 
      yoy
    		90.32% 119.07% -20.14% 14.69% 213.87% -150.27% 2897.22% -138.48% -209.76% 139.77% -103.28% -61.95% -3.18% 88.03% -22.47% 70.14% -35.45% -82.92% 4.11% -24.51% 25.88% 101.68% -23.30% 3.19% -19.02% -32.44% -13.16% 57.11% -4.91% -4.77% -6.19% -38.19% -12.48% -8.89% -5.44% 76.53% 71.89% 84.07% 81.12% 23.25% 61.40% 56.97% 83.20% 126.47% 135.42% 131.75% 136.70% 191.16% 76.93% 345.25% 67.58% -1.53% 28.49% -52.68% -17.34% 6.60% -118.19% 20.09% 52.89% 6.31% -435.38% -51.57% -66.31% -63.42% -37.77% -44.10% -30.40% -8.42% -18.05% -2.69% 70.06% 30.48% 36.86% 42.46% -9.39% 32.61% 22.02% -8.48% 96.57% 69.38% 39.10% 98.02% 2.55%     
      qoq
    		281.13% 169.18% 40.44% -86.79% 338.71% -1.87% 101.69% -63.85% -170.27% -5950.63% -102.59% 3.11% 53.50% -20.08% -69.92% 162.35% 198.08% -67.05% -33.98% -0.47% -21.14% 100.90% -52.13% 65.97% 26.34% -23.59% -35.59% 30.25% 5.40% -1.78% 16.52% -21.16% 5.55% -3.25% -23.23% 11.62% 9.89% 0.41% 43.33% 8.69% 17.68% -1.20% -2.47% 42.34% 14.44% 15.31% 20.57% 47.96% 12.66% 17.77% 48.31% -10.09% 183.51% -55.67% -12.85% 17.32% 4.41% -22.57% 12.39% -120.02% -789.40% -1.42% -21.85% -36.85% -0.45% -31.43% -15.15% 7.43% -10.57% -14.62% 11.64% -3.87% 6.20% 49.21% -14.35% 0.84% 10.54% -5.09% 25.35% -7.21% -17.09% 103.85% 8.01% -23.80% 18.03% 5.57%  
      net income margin %
    		96.33% 25.76% 10.08% 7.77% 55.37% 13.09% 13.80% 8.04% 19.82% -30.79% 0.67% -36.32% -30.57% -20.80% -25.28% -97.91% -32.96% -10.98% -38.08% -62.36% -55.17% -70.21% -38.27% -97.73% -53.94% -44.38% -66.03% -135.49% -109.94% -106.57% -110.87% -111.11% -158.10% -183.39% -221.30% -574.66% -657.88% -1359.40% -73527.84% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -677.02% -393.00% -579.55% 
      earnings per share:
    		                                                                                       
      basic
    		0.175 0.43 0.16 0.11                                                                                    
      diluted
    		0.173 0.42 0.16 0.11                                                                                    
      weighted-average common shares outstanding:
    		                                                                                       
      basic
    		168,356 168,836 167,827 166,808 165,717 165,974 165,551 164,798   163,458                                                                             
      diluted
    		169,919 170,650 168,681 167,668 166,362 166,178 166,174 166,623   165,046                                                                             
      earnings (net loss) per share:
    		                                                                                       
      basic
    		    0.87 0.2 0.2 0.1   0.01                                                                             
      diluted
    		    0.86 0.2 0.2 0.1   0.01                                                                             
      net loss per common share, basic and diluted
    		        280 -400  -270 -260 -170 -210 -700 -270 -90 -270 -420         -360 -500 -510 -440                    -80 -65 -40  -120                                
      weighted-average common shares outstanding, basic and diluted
    		        163,819,000 164,234,000  162,263,000 161,683,000 161,852,000 161,654,000 161,231,000 160,493,000 160,663,000 160,421,000 160,011,000 157,331,000 158,129,000 156,535,000 155,368,000 147,199,000 145,906,000 144,314,000 143,981,000 126,583,000 125,009,000 124,910,000 124,727,000 122,600,000 122,484,000 122,122,000 121,651,000 115,858,000 117,497,000 113,308,000 111,346,000 100,630,000 100,756,000 100,349,000 100,197,000 97,248,000 99,497,000 99,048,000 92,968,000 85,715,000 89,504,000 83,410,000 78,748,000  53,911,000 52,961,000 52,903,000  52,800,000 52,677,000 50,367,000  38,383,000 38,347,000 38,333,000 37,476,000 37,383,000 37,220,000 37,179,000 37,113,000 37,137,000 37,102,000 37,053,000 35,211,000 36,946,000 36,894,000 30,016,000 27,923,000 29,732,000 27,792,000 24,308,000 22,014,443 23,343,309 23,274,186 17,903,209 10,353,351 16,628,914 6,552,366 
      weighted-average shares outstanding:
    		                                                                                       
      basic
    		168,356 168,836 167,827 166,808 165,717 165,974 165,551 164,798   163,458                                                                             
      diluted
    		169,919 170,650 168,681 167,668 166,362 166,178 166,174 166,623   165,046                                                                             
      license fees and royalties
    		                117,000 2,994,000 2,680,000 2,507,000 2,793,000 2,796,000 2,575,000 2,175,000 2,314,000 2,273,000 2,037,000 1,630,000 1,569,000 1,536,000 1,516,000 1,332,000 1,248,000 1,078,000 982,000 675,000 608,000 475,000 248,000                                                 
      net income per common share, basic and diluted
    		                    -342.5 -540 -270 -570 -340 -290 -380 -590     -452.5 -530 -550 -720 -650 -610 -630 -450 -450 -390 -390 -400 -290 -250 -220 -190 -130 -120 -110      -85 -100 -120 -120 -92.5 -110 -110 -140 -220 -230 -340 -400 -370 -420 -490 -440 -460 -430 -290 -420 -1,608.8 -0.38 -0.43 -0.39 -0.44 -0.53 -0.26 -0.31 -0.45 -0.37 -0.42 
      income tax (benefit) expense
    		                        119,000 -264,000                                                              
      other expense
    		                            -491,750 -1,720,000 -247,000                                                         
      collaborative revenue
    		                                                                                       
      collaborative revenues
    		                                       4,000 17,000 39,000 1,000 4,000 48,000 15,000 28,000 30,000 37,000 240,000 451,000 417,000 380,000 3,478,000 599,000 450,000 588,000 584,000 460,000 435,000 35,404,000 2,301,000 2,297,000 2,133,000 1,769,000 2,435,000 1,820,000 374,000 325,000 282,000 177,000 806,000 1,583,000 1,957,000 2,055,000 1,960,000 1,773,000 1,943,000 1,881,000 2,537,000 2,443,000 3,673,500 2,514,600 2,325,200    
      general and administrative
    		                                       27,491,000 22,616,000 20,308,000 21,119,000 24,261,000 10,420,000 8,057,000 7,952,000 6,320,000 4,276,000 3,797,000 2,496,000 2,151,000 2,298,000 1,485,000 1,556,000 1,660,000 1,478,000 1,519,000 2,729,000 1,884,000 1,518,000 1,578,000 1,552,000 1,814,000 2,639,000 1,994,000 2,662,000 2,988,000 2,390,000 2,974,000 3,184,000 3,270,000 3,010,000 2,941,000 3,163,000 3,152,000 4,404,000 2,364,000 2,296,000 2,284,000 2,598,800 2,098,300 2,050,300 1,638,600 1,787,400 1,311,000 879,900 
      comprehensive loss
    		                                                    -3,511,000 -2,400,000 -5,422,000 -6,221,000                                
      interest expense
    		                                                               -12,000 -16,000 -21,000 -24,000 -24,000 -37,000 -46,000 -46,000 -52,000 -63,000 -71,000 -70,000 -65,000 -60,000 -51,000 -44,000 -43,000 -52,000 -40,300 -37,600 -50,300 -77,500 -96,400 -118,600 
      benefit from income from (settlement of) litigation
    		                                                                             -3,981,000          
      income before change in accounting principle
    		                                                                        -17,039,000 -16,045,000 -10,753,000 -12,554,000 -12,450,000 -11,263,000 -11,867,000 -9,518,000        
      cumulative effect of change in accounting principle
    		                                                                               51,000        
      before change in accounting principle
    		                                                                        -460 -430 -290 -420 -1,608.8 -0.38 -0.43 -0.39        
      benefit from income from litigation
    		                                                                              194,000 227,000 360,000 5,861,000      
      net income per common share, basic and diluted:
    		                                                                                       
      stock-based compensation
    		                                                                                79,800 461,800 394,900 371,200 376,500 669,600 614,500 
      participation of preferred stock
    		                                                                                      -3,109,900 
      net income available to common stockholders
    		                                                                                -10,202,900 -12,306,100 -6,036,900 -5,589,200 -7,334,800 -6,214,500 -2,776,600 
      net income available to participating preferred stockholders
    		                                                                                      -3,109,900 
      net income per participating preferred share, basic and diluted
    		                                                                                      -0.31 
      weighted-average participating preferred shares outstanding, basic and diluted
    		                                                                                    9,900,913  9,900,913 
      excludes stock-based compensation as follows:
    		                                                                                       
      collaborative revenues—related party
    		                                                                                    1,083,400 1,506,300 1,015,700 
      other collaborative research revenues
    		                                                                                     75,000  
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 
                                                                                             
        assets
      		                                                                                       
        cash and cash equivalents
      		177,695,000 257,996,000 253,637,000 217,696,000 319,589,000 155,149,000 177,134,000 204,745,000 188,657,000 98,193,000 107,941,000 290,895,000 114,846,000 154,842,000 139,833,000 204,920,000 147,435,000 94,640,000 266,956,000 304,487,000 326,028,000 452,352,000 310,441,000 173,059,000 189,680,000 385,474,000 74,432,000 97,557,000 134,758,000 63,897,000 74,182,000 116,328,000 69,418,000 112,616,000 143,789,000 157,383,000 163,620,000 153,679,000 131,774,000 175,220,000 102,138,000 70,799,000 93,212,000 76,424,000 61,854,000 36,369,000 13,698,000 96,455,000 11,707,000 11,803,000 24,247,000 18,436,000 57,899,000 8,016,000 9,208,000 5,558,000 6,889,000 8,317,000 8,020,000 6,829,000 6,849,000 9,656,000 8,811,000 18,067,000 18,122,000 17,322,000 17,984,000 18,840,000 21,171,000 22,213,000 20,285,000 21,005,000 16,987,000 23,462,000 39,631,000 22,315,000 15,480,000 26,229,000 38,420,000 11,264,000 9,796,100 23,352,700 15,812,400 11,235,900 8,301,700 5,692,600 8,156,500 
        investment securities, available-for-sale
      		641,991,000 589,023,000 508,359,000 463,881,000 436,404,000 410,181,000 323,808,000 265,775,000 250,208,000 247,727,000 267,437,000 111,978,000 301,977,000 281,737,000 296,518,000 241,057,000 373,271,000 445,651,000 289,962,000 273,281,000 305,930,000 192,089,000 348,110,000 478,347,000 507,749,000 298,373,000 307,455,000 316,767,000 338,762,000 150,239,000 182,673,000 181,735,000 271,924,000 254,009,000 273,531,000 312,098,000 365,416,000 435,180,000 280,781,000 282,023,000 112,994,000 169,892,000 177,565,000 221,469,000 260,632,000 301,430,000 340,755,000 272,830,000 174,083,000 184,377,000 181,204,000 83,027,000 50,068,000 15,042,000 12,141,000 20,366,000 24,159,000 27,833,000 32,341,000 38,835,000 30,238,000 22,570,000 25,464,000 22,509,000 28,938,000 37,587,000 48,168,000 27,544,000 38,912,000 50,485,000 69,336,000 85,494,000 109,871,000 117,500,000 114,238,000 47,584,000 67,775,000 68,428,000 55,715,000 32,420,000 33,204,900 39,378,400 53,148,400 30,410,200 27,625,700 37,465,200 40,636,200 
        accounts receivable
      		121,457,000 115,850,000 107,505,000 105,743,000 98,739,000 98,209,000 103,698,000 94,701,000 98,267,000 92,802,000 81,852,000 65,915,000 62,195,000 55,733,000 67,953,000 62,713,000 64,366,000 60,696,000 51,367,000 56,832,000 48,247,000 46,344,000 43,785,000 41,636,000 35,781,000 30,804,000 31,781,000 29,958,000 26,090,000 19,958,000 25,696,000 22,445,000 17,343,000 14,221,000 11,594,000 7,660,000 5,903,000 3,839,000 293,000                       1,934,000 2,930,000                         
        interest and other receivables
      		26,774,000 23,588,000 12,181,000 7,971,000 5,956,000 12,154,000 6,695,000 5,378,000 4,083,000 1,730,000 2,304,000 4,335,000 885,000 403,000 936,000 769,000 978,000 972,000 453,000 558,000 2,035,000 1,440,000 2,343,000 2,935,000 2,093,000 1,465,000 941,000 3,812,000 1,699,000 724,000 986,000 903,000 1,087,000 1,033,000 784,000 1,859,000 1,237,000 1,385,000 1,340,000 783,000 1,638,000 206,000 1,508,000 746,000 964,000 1,139,000 1,320,000 1,642,000                                        
        inventory
      		34,670,000 29,097,000 26,124,000 22,948,000 21,949,000 61,041,000 71,525,000 61,936,000 35,819,000 20,768,000 9,199,000 6,095,000 6,636,000 5,844,000 6,327,000 7,009,000 7,881,000 14,336,000 10,786,000 10,311,000 9,682,000 7,979,000 6,210,000 6,318,000 6,341,000 4,846,000 3,824,000 4,570,000 4,070,000 4,347,000 4,737,000 5,583,000 5,248,000 5,536,000 6,003,000 3,881,000 4,175,000 4,301,000 2,867,000                                                 
        prepaid expenses
      		59,526,000 60,868,000 52,747,000 52,703,000 55,681,000 51,550,000 46,056,000 42,761,000 39,091,000 37,950,000 23,895,000 23,632,000 21,398,000 22,993,000 20,952,000 25,755,000 23,892,000 24,622,000 26,206,000 28,515,000 25,694,000 30,009,000 24,846,000 22,126,000 18,606,000 21,368,000 18,507,000 23,742,000 20,727,000 14,951,000 12,822,000 13,020,000 8,457,000 14,557,000 8,044,000 6,872,000            1,893,000                                        
        total current assets
      		1,062,113,000 1,076,422,000 960,553,000 870,942,000 938,318,000 788,284,000 728,916,000 675,296,000 616,125,000 499,170,000 492,628,000 502,850,000 507,937,000 521,552,000 532,519,000 542,223,000 617,823,000 640,917,000 645,730,000 673,984,000 717,616,000 730,213,000 735,735,000 724,421,000 760,250,000 742,330,000 436,940,000 476,406,000 526,106,000 254,116,000 301,096,000 340,014,000 373,477,000 401,972,000 443,745,000 489,753,000 547,897,000 603,490,000 423,897,000 462,352,000 218,989,000 242,847,000 273,393,000 299,899,000 324,618,000 341,065,000 358,854,000 372,820,000 188,360,000 198,675,000 206,761,000 102,985,000 108,548,000 23,685,000 21,775,000 26,387,000 31,949,000 36,763,000 41,015,000 46,548,000 37,849,000 34,992,000 38,318,000 42,267,000 48,473,000 56,804,000 68,214,000 48,287,000 62,382,000 75,535,000 93,107,000 110,170,000 131,253,000 144,951,000 156,893,000 72,365,000 85,783,000 97,804,000 112,661,000 61,121,000 60,124 67,999,500 71,398,200 43,652,600 37,818,100 44,905,400 50,258,100 
        property and equipment
      		7,511,000 3,708,000 3,547,000 3,498,000 4,215,000 3,988,000 4,144,000 4,370,000 4,612,000 4,884,000 5,193,000 5,595,000 6,021,000 6,510,000 7,016,000 7,531,000 8,047,000 8,581,000 9,197,000 9,757,000 9,161,000 8,427,000 6,687,000 5,089,000 3,180,000 3,249,000 3,427,000 3,737,000 3,309,000 3,372,000 2,760,000 2,709,000 2,662,000 2,991,000 3,296,000 3,471,000 3,081,000 3,159,000 2,897,000 2,623,000 2,203,000 2,068,000 1,813,000 1,786,000 553,000 520,000 500,000 543,000 579,000 490,000 92,000 30,000 42,000 63,000 92,000 121,000 151,000 181,000 208,000 244,000 426,000 622,000 698,000 870,000 1,062,000 1,498,000 1,657,000 1,846,000 2,103,000 2,420,000 2,712,000 2,919,000 3,048,000 3,095,000 3,141,000 3,287,000 3,505,000 3,014,000 2,811,000 2,299,000 2,283,100 2,249,300 2,232,300 2,271,700 2,546,900 2,549,000 2,760,700 
        operating lease right-of-use assets
      		47,354,000 49,673,000 50,991,000 50,614,000 46,571,000 44,253,000 52,390,000 54,280,000 51,855,000 50,758,000 52,382,000 54,151,000 55,573,000 56,624,000 57,417,000 58,186,000 58,268,000 60,032,000 61,371,000 63,111,000 47,283,000 48,232,000 7,880,000 8,613,000 9,524,000 9,959,000 10,818,000 10,918,000                                                            
        intangible assets
      		108,893,000 111,615,000 114,338,000 117,060,000 119,782,000 105,515,000 107,859,000 110,204,000 65,490,000 66,855,000 68,219,000 69,583,000       369,000 738,000 1,108,000 1,477,000 1,846,000 2,215,000 2,585,000 2,954,000 3,323,000 3,692,000 4,062,000 4,431,000 4,800,000 5,169,000 5,538,000 5,907,000 6,277,000 6,646,000 7,015,000 7,385,000 7,754,000                                                 
        restricted cash
      		7,845,000 9,471,000 9,471,000 8,770,000 8,770,000 8,770,000 5,770,000 5,770,000 5,770,000 5,770,000 8,120,000 5,770,000 5,770,000 5,770,000 5,770,000 5,770,000 5,770,000 5,770,000 5,770,000 5,770,000 5,770,000 5,770,000 5,770,000 5,770,000 4,787,000 4,787,000 4,787,000 4,787,000 4,826,000 3,111,000 3,111,000 2,825,000 2,475,000 2,475,000 2,475,000 2,475,000 2,375,000 2,375,000 2,375,000 375,000 375,000                                      12,520,000 12,520,000 12,520,000       
        long-term inventory
      		76,704,000 76,888,000 84,402,000 80,025,000 69,741,000 25,699,000 14,544,000 4,707,000 4,628,000 4,628,000 4,924,000 4,924,000 4,924,000 5,992,000 6,205,000 6,205,000 6,217,000                                                                       
        deferred tax assets
      		249,879,000                                                                                       
        other assets
      		3,896,000 2,994,000 2,253,000 1,455,000 359,000 359,000 476,000 476,000 476,000 475,000 11,303,000 12,432,000 7,587,000 6,043,000 3,839,000 4,336,000 3,997,000 2,373,000 1,992,000 1,813,000 1,678,000 1,545,000 1,731,000 1,342,000 2,857,000 2,307,000 1,588,000 1,565,000 1,899,000 1,426,000 3,193,000 323,000 354,000 369,000 522,000 668,000 785,000 975,000 1,111,000 1,240,000 329,000 405,000 333,000 278,000 287,000 178,000 111,000 143,000 179,000 120,000 56,000   2,000 7,000 11,000 14,000 78,000 86,000 95,000 119,000 136,000 150,000 136,000 145,000 173,000 192,000 238,000 192,000 248,000 261,000 236,000 283,000 300,000 187,000 96,000 256,000 96,000 96,000 98,000 98,000 21,800    295,100 284,700 
        total assets
      		1,564,195,000 1,330,771,000 1,225,555,000 1,132,364,000 1,187,756,000 976,868,000 914,099,000 855,103,000 748,956,000 632,540,000 642,769,000 655,305,000 587,812,000 602,491,000 612,766,000 624,251,000 700,122,000 717,673,000 724,429,000 755,173,000 782,616,000 795,664,000 759,649,000 747,450,000 783,183,000 765,586,000 460,883,000 501,105,000 540,202,000 266,456,000 314,960,000 351,040,000 384,506,000 413,714,000 456,315,000 503,013,000 561,153,000 617,384,000 438,034,000 466,590,000 221,896,000 245,320,000 275,539,000 301,963,000 325,458,000 341,763,000 359,465,000 373,506,000 189,118,000 199,285,000 206,909,000 103,015,000 108,590,000 23,750,000 21,874,000 26,519,000 32,114,000 37,022,000 41,309,000 46,887,000 38,394,000 35,750,000 39,166,000 43,273,000 49,680,000 58,475,000 70,063,000 50,371,000 64,677,000 78,203,000 96,080,000 113,325,000 134,584,000 148,346,000 160,221,000 75,748,000 89,544,000           
        liabilities and stockholders’ equity
      		                                                                                       
        accounts payable
      		10,903,000 21,747,000 20,097,000 18,095,000 16,192,000 19,081,000 19,882,000 19,332,000 17,543,000 12,310,000 18,811,000 17,422,000 12,746,000 10,008,000 11,854,000 10,768,000 6,876,000 7,722,000 9,065,000 8,849,000 8,493,000 3,471,000 6,466,000 6,623,000 7,222,000 3,444,000 4,650,000 3,275,000 3,167,000 2,955,000 3,333,000 2,996,000 8,786,000 2,962,000 3,588,000 2,166,000 3,912,000 2,828,000 1,024,000 1,307,000 1,672,000 2,204,000 2,916,000 2,518,000 2,016,000 1,110,000 1,104,000 1,562,000 372,000 1,120,000 1,177,000 1,396,000 1,375,000 1,131,000 757,000 1,035,000 1,960,000 1,262,000 1,139,000 1,380,000 1,972,000 2,617,000 2,300,000 2,122,000 2,947,000 2,554,000 3,981,000 4,185,000 2,283,000 2,450,000 3,217,000 2,047,000 2,590,000 2,950,000 2,273,000 3,058,000 3,387,000 3,206,000 3,419,000 733,000 2,073,300 1,729,500 2,317,200 1,356,500 2,152,800 2,450,300 1,984,600 
        accrued liabilities
      		266,211,000 334,837,000 309,927,000 284,435,000 378,678,000 324,864,000 317,969,000 311,265,000 236,711,000 197,293,000 169,131,000 206,879,000 112,884,000 106,562,000 105,827,000 108,835,000 89,192,000 80,496,000 86,263,000 100,524,000 97,474,000 88,385,000 79,956,000 93,118,000 67,604,000 64,300,000 59,164,000 71,708,000 56,398,000 38,852,000 45,881,000 43,093,000 40,244,000 33,181,000 37,325,000 38,967,000 36,029,000 34,445,000 27,485,000 19,815,000 20,230,000 15,531,000 16,462,000                                             
        total current liabilities
      		277,114,000 356,584,000 330,024,000 302,530,000 394,870,000 343,945,000 337,851,000 330,597,000 254,254,000 209,603,000 187,942,000 224,301,000 125,630,000 116,570,000 117,681,000 119,603,000 96,068,000 88,218,000 95,328,000 109,373,000 105,967,000 91,856,000 86,422,000 99,741,000 74,826,000 67,744,000 63,814,000 74,983,000 59,565,000 41,807,000 49,214,000 46,089,000 49,030,000 36,143,000 40,913,000 45,265,000 42,585,000 39,149,000 29,022,000 21,122,000 21,902,000 17,735,000 19,378,000 16,651,000 15,834,000 11,253,000 9,339,000 8,033,000 6,979,000 7,870,000 7,776,000 5,695,000 5,948,000 6,086,000 6,760,000 6,433,000 6,165,000 6,409,000 5,947,000 6,139,000 5,959,000 13,168,000 12,984,000 13,550,000 14,707,000 15,248,000 20,936,000 11,436,000 11,051,000 11,202,000 13,889,000 13,472,000 19,287,000 17,155,000 14,326,000 17,272,000 20,534,000 20,767,000 25,306,000 21,743,000 21,701,400 19,689,100 11,077,800 11,692,500 8,640,600 9,364,000 9,565,400 
        operating lease liabilities
      		40,554,000 43,026,000 44,601,000 44,634,000 42,037,000 40,421,000 47,186,000 49,189,000 47,800,000 48,103,000 49,778,000 51,441,000 52,695,000 53,769,000 54,693,000 55,478,000 56,126,000 57,677,000 59,134,000 60,581,000 44,460,000 45,343,000 5,669,000 6,090,000 6,361,000 6,379,000 6,742,000 6,754,000                                                            
        other long-term liabilities
      		19,137,000 13,889,000 28,548,000 19,963,000 18,056,000 15,322,000 12,362,000 11,273,000 15,147,000 12,660,000 9,256,000 5,305,000 9,074,000 6,466,000 5,544,000 4,373,000 7,034,000 4,823,000 5,129,000 3,613,000 5,180,000 3,598,000 4,545,000 3,237,000 2,861,000 2,174,000 1,413,000 1,012,000                              28,000 60,000 92,000 92,000 113,000 131,000 225,000 182,000 197,000 206,000 225,000 204,000 199,000 257,000 247,000 207,000 202,000 186,000 178,000 472,000 602,000 883,000 1,183,000 541,700 458,000      
        total liabilities
      		336,805,000 413,499,000 403,173,000 367,127,000 454,963,000 399,688,000 397,399,000 391,059,000 317,201,000 270,366,000 246,976,000 281,047,000 187,399,000 176,805,000 177,918,000 179,454,000 159,228,000 150,718,000 159,591,000 173,567,000 155,607,000 140,797,000 96,636,000 109,068,000 84,048,000 76,297,000 71,969,000 82,749,000 61,123,000 43,016,000 50,240,000 46,871,000 49,221,000 36,388,000 41,175,000 45,489,000 42,742,000 39,326,000 29,219,000 21,339,000 22,134,000 17,974,000 19,718,000 16,869,000 15,969,000 11,274,000 9,357,000 8,046,000 6,987,000 7,872,000   5,948,000 6,086,000 9,166,000 8,934,000 8,752,000 8,878,000 8,488,000 8,779,000 8,706,000 35,924,000 36,010,000 36,175,000 37,566,000 39,508,000 43,650,000 11,985,000 11,685,000 11,961,000 14,876,000 14,658,000 20,650,000 18,612,000 15,951,000 18,953,000 22,385,000 22,513,000 27,022,000 23,659,000 23,134,700 21,073,800      
        commitments and contingencies
      		                                                                                       
        stockholders’ equity:
      		                                                                                       
        preferred stock, 0.0001 par value...
      		                                                                                       
        common stock, 0.0001 par value...
      		16,000 16,000 16,000 16,000 16,000 16,000 16,000 16,000 16,000 16,000 16,000 16,000 16,000 16,000 16,000 16,000 16,000 16,000 16,000 16,000 16,000 16,000 15,000 15,000 15,000 15,000 14,000 14,000 14,000 12,000 12,000 12,000 12,000 12,000 12,000 12,000 12,000 12,000 11,000 11,000 10,000 10,000 10,000 10,000 10,000 10,000 10,000 10,000 9,000 9,000 8,000 7,000 7,000 6,000 5,000 5,000 5,000 5,000 5,000 5,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 4,000 3,000 3,000 3,000 3,000 2,000 2,400 2,300 2,300 1,800 1,700 1,700 1,700 
        additional paid-in capital
      		3,039,315,000 3,003,221,000 2,980,693,000 2,950,183,000 2,936,871,000 2,924,434,000 2,897,916,000 2,878,539,000 2,862,552,000 2,839,111,000 2,807,770,000 2,787,034,000 2,770,923,000 2,754,861,000 2,736,318,000 2,712,025,000 2,694,646,000 2,677,422,000 2,660,809,000 2,633,710,000 2,612,663,000 2,573,288,000 2,495,804,000 2,428,987,000 2,402,945,000 2,339,940,000 1,997,454,000 1,972,302,000 1,948,300,000 1,627,113,000 1,606,441,000 1,582,823,000 1,559,343,000 1,532,188,000 1,504,778,000 1,479,530,000 1,452,272,000 1,432,796,000 1,192,268,000 1,157,272,000 862,327,000 844,093,000 833,696,000 823,598,000 807,631,000 800,179,000 794,995,000 788,946,000 587,742,000 574,280,000 564,417,000 453,483,000 452,693,000 378,564,000 371,208,000 370,663,000 370,219,000 369,704,000 369,301,000 367,505,000 353,278,000 352,541,000 351,771,000 351,357,000 350,872,000 349,322,000 348,137,000 347,391,000 346,815,000 346,227,000 345,416,000 344,231,000 343,293,000 342,115,000 340,742,000 242,625,000 240,446,000 239,220,000 238,254,000 177,910,000 168,426,100 168,345,300 168,244,100 133,685,700 126,755,100 126,772,500 126,626,000 
        accumulated deficit
      		-1,813,386,000 -2,086,954,000 -2,158,733,000 -2,185,399,000 -2,204,386,000 -2,348,128,000 -2,380,893,000 -2,414,282,000 -2,430,837,000 -2,476,634,000 -2,411,458,000 -2,412,572,000 -2,369,551,000 -2,327,826,000 -2,300,643,000 -2,266,632,000 -2,153,576,000 -2,110,482,000 -2,096,025,000 -2,052,154,000 -1,985,706,000 -1,918,946,000 -1,834,286,000 -1,792,145,000 -1,704,122,000 -1,651,086,000 -1,609,108,000 -1,554,167,000 -1,468,863,000 -1,403,371,000 -1,341,233,000 -1,277,967,000 -1,223,671,000 -1,154,801,000 -1,089,553,000 -1,022,112,000 -933,979,000 -855,283,000 -783,670,000 -712,348,000 -662,586,000 -616,802,000 -577,896,000 -538,518,000 -498,143,000 -469,777,000 -444,991,000 -423,496,000 -405,668,000 -393,619,000 -382,924,000 -373,843,000 -367,720,000 -360,910,000 -358,508,000 -353,089,000 -346,871,000 -341,571,000 -336,495,000 -329,939,000 -324,106,000 -353,247,000 -349,020,000 -344,732,000 -339,245,000 -330,556,000 -321,828,000 -309,101,000 -294,100,000 -280,137,000 -264,523,000 -246,236,000 -229,856,000 -212,818,000 -196,773,000 -186,020,000 -173,466,000 -161,016,000 -149,753,000 -137,885,000 -128,418,100 -118,215,200 -105,909,100 -99,872,200 -94,283,000 -86,948,200 -80,733,600 
        accumulated other comprehensive income
      		1,445,000 989,000 406,000 437,000 292,000 858,000 -339,000 -229,000 24,000        -192,000 -1,000 38,000 34,000 36,000 509,000 1,480,000 1,525,000 297,000        -399,000 -73,000 -97,000 94,000 106,000 533,000 206,000 316,000 11,000 45,000 11,000 4,000 -9,000 77,000 94,000  48,000 84,000 -26,000 15,000 4,000 4,000 3,000 6,000 9,000 6,000 10,000 537,000 512,000 528,000 401,000 469,000 483,000 197,000 100,000 92,000 273,000 148,000 307,000 668,000 493,000 433,000 313,000 226,000 240,000 336,000 259,000 142,000 133,500 159,800 198,600 266,700 314,400 298,300 320,600 
        total stockholders’ equity
      		1,227,390,000 917,272,000 822,382,000 765,237,000 732,793,000 577,180,000 516,700,000 464,044,000 431,755,000 362,174,000 395,793,000 374,258,000 400,413,000 425,686,000 434,848,000 444,797,000 540,894,000 566,955,000 564,838,000 581,606,000 627,009,000 654,867,000 663,013,000 638,382,000 699,135,000 689,289,000 388,914,000 418,356,000 479,079,000 223,440,000 264,720,000 304,169,000 335,285,000 377,326,000 415,140,000 457,524,000 518,411,000 578,058,000 408,815,000 445,251,000 199,762,000 227,346,000 255,821,000 285,094,000 309,489,000 330,489,000 350,108,000 365,460,000 182,131,000 180,754,000 181,475,000 79,662,000 84,984,000 17,664,000 12,708,000 17,585,000 23,362,000 28,144,000 32,821,000 38,108,000 29,688,000 -174,000 3,156,000 7,098,000 12,114,000 18,967,000 26,413,000 38,386,000 52,992,000 66,242,000 81,204,000 98,667,000 113,934,000 129,734,000 144,270,000 56,795,000 67,159,000 78,401,000 88,546,000 39,859,000 39,371,100 49,196,800 61,149,500 32,370,600 30,680,400 37,359,200 42,791,800 
        total liabilities and stockholders’ equity
      		1,564,195,000 1,330,771,000 1,225,555,000 1,132,364,000 1,187,756,000 976,868,000 914,099,000 855,103,000 748,956,000 632,540,000 642,769,000 655,305,000 587,812,000 602,491,000 612,766,000 624,251,000 700,122,000 717,673,000 724,429,000 755,173,000 782,616,000 795,664,000 759,649,000 747,450,000 783,183,000 765,586,000 460,883,000 501,105,000 540,202,000 266,456,000 314,960,000 351,040,000 384,506,000 413,714,000 456,315,000 503,013,000 561,153,000 617,384,000 438,034,000 466,590,000 221,896,000 245,320,000 275,539,000 301,963,000 325,458,000 341,763,000 359,465,000 373,506,000      23,750,000 21,874,000 26,519,000  37,022,000 41,309,000 46,887,000  35,750,000 39,166,000 43,273,000  58,475,000 70,063,000 50,371,000  78,203,000 96,080,000 113,325,000  148,346,000 160,221,000 75,748,000            
        accumulated other comprehensive loss
      		         -319,000 -535,000 -220,000 -975,000 -1,365,000 -843,000 -612,000             -372,000 -314,000 -500,000 -699,000                                                        
        accumulated other comprehensive gain
      		                         420,000 554,000 207,000                                                            
        long-term liabilities
      		                            1,558,000 1,209,000 1,026,000 782,000 191,000 245,000 262,000 224,000 157,000 177,000 197,000 217,000 232,000 239,000 340,000 218,000 135,000 21,000 18,000 13,000 8,000 2,000                                      
        deferred revenue
      		                                   4,132,000 2,644,000 1,876,000 513,000       15,000 29,000 42,000 55,000 80,000 111,000 140,000                92,000  170,000 170,000 170,000             1,320,300 1,653,600 1,986,900 
        prepaid expenses and other current assets
      		                                    7,546,000 5,106,000 6,842,000 4,326,000 2,219,000 1,950,000 1,108,000 1,260,000 1,168,000 2,127,000 3,081,000               832,000 1,113,000                    2,437,400 2,006,500 1,890,700 1,747,600 1,465,400 
        accrued expenses
      		                                           14,133,000 13,818,000 10,128,000 8,206,000 6,429,000 6,552,000 6,670,000 6,488,000 4,159,000 4,139,000 4,686,000 5,225,000 4,693,000 3,504,000 4,402,000 4,015,000 4,253,000 3,219,000 3,760,000 4,128,000 5,048,000 5,358,000 6,340,000 7,270,000 6,474,000 7,535,000 7,767,000 9,620,000 10,321,000 15,012,000 11,524,000 8,510,000 10,050,000 13,485,000 13,868,000 8,014,000 7,227,000 6,582,200 4,515,300 3,404,700 3,656,600 3,681,100 3,200,700 2,989,800 
        stockholders’ equity
      		                                                                                       
        prepaid expenses, receivables and other current assets
      		                                                2,570,000 2,495,000 1,310,000 1,522,000 581,000 627,000 426,000 463,000 901,000 613,000 654,000 884,000 762,000   1,691,000 1,413,000 1,895,000 2,062,000 1,903,000 2,299,000 2,837,000 3,486,000 3,671,000 4,395,000 3,989,000 3,024,000 2,466,000 2,528,000 3,147,000 6,006,000 4,917,000 4,603,700 5,268,400      
        liabilities, redeemable common stock and stockholders’ equity
      		                                                                                       
        redeemable common stock, 0.0001 par value...
      		                                                 10,659,000 17,658,000 17,658,000 17,658,000                                   
        total liabilities, redeemable common stock and stockholders’ equity
      		                                                189,118,000 199,285,000 206,909,000 103,015,000 108,590,000                                   
        current portion of deferred revenue
      		                                                    434,000 266,000 765,000 683,000 669,000 708,000 753,000 462,000 690,000 6,680,000 6,395,000 6,089,000 6,037,000 5,904,000 9,125,000  438,000    707,000 1,664,000 2,496,000 3,125,000 2,666,000 2,791,000 3,916,000 4,041,000 3,445,500 4,167,900 4,501,300 5,834,600    
        current portion of long-term debt
      		                                                     3,000 13,000 22,000 32,000 37,000 40,000 44,000 78,000 111,000 161,000 291,000 365,000 450,000 560,000 685,000 795,000 815,000 882,000 934,000 978,000 1,017,000 1,047,000 1,039,000 996,000 902,000 826,000 805,000 890,400 926,400 854,600 844,800 1,486,400 2,059,400 2,604,100 
        long-term portion of deferred revenue
      		                                                      2,406,000 2,501,000 2,587,000 2,441,000 2,481,000 2,548,000 2,623,000 22,602,000 22,844,000 22,335,000 22,579,000 23,909,000 22,280,000                     
        commitments
      		                                                                                       
        long-term debt, less current portion
      		                                                            32,000 41,000 51,000 65,000 98,000 154,000 228,000 324,000 430,000 560,000 730,000 939,000 1,156,000 1,255,000 1,439,000 1,503,000 1,379,000 1,144,000 833,000 733,000 891,600 926,700 818,900 854,000 1,044,000 1,026,300 946,300 
        unearned stock-based compensation
      		                                                                          -16,000 -39,000 -64,000 -142,000 -217,000 -310,000 -772,800 -1,095,400 -1,386,400 -1,711,400 -2,107,800 -2,765,100 -3,422,900 
        accrued income from litigation
      		                                                                              9,131,000 8,937,000 8,710,000 8,350,000      
        deferred revenue, less current portion
      		                                                                                  584,300 1,007,200    
        convertible preferred stock, 0.01 par value...
      		                                                                                       
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 
                                                                                              
          cash flows from operating activities
        		                                                                                      
          net income
        		273,568,000 71,779,000 26,666,000 18,987,000 143,742,000 32,765,000 33,389,000 16,555,000              -84,660,000 -42,141,000 -88,023,000 -53,036,000 -41,978,000 -54,941,000 -85,304,000      -65,248,000 -67,441,000 -87,843,000 -78,696,000 -71,613,000 -71,322,000 -49,762,000 -45,784,000 -38,906,000 -39,378,000 -40,375,000 -28,366,000 -24,786,000 -21,495,000 -17,828,000 -12,049,000 -10,695,000       -5,300,000 -5,076,000 -6,556,000 -5,833,000 29,141,000 -4,227,000 -4,288,000 -5,487,000 -8,689,000 -8,728,000 -12,727,000 -15,001,000 -13,963,000 -15,614,000 -18,287,000 -16,380,000 -17,039,000 -16,044,000 -10,753,000 -12,554,000 -12,450,000 -11,263,000 -11,868,000 -9,467,000 -10,202,900 -12,306,100 -6,036,900 -5,589,200 -7,334,800 -6,214,600 
          adjustments to reconcile net income to net cash from operating activities:
        		                                                                                      
          stock-based compensation
        		13,235,000 13,180,000 14,340,000 11,380,000 10,450,000 26,164,000 15,685,000 14,750,000 18,023,000 18,539,000 15,154,000 14,705,000 14,414,000 18,312,000 20,512,000 14,963,000 12,880,000 15,546,000 22,005,000 13,184,000 21,195,000 21,372,000 19,507,000 22,348,000 19,763,000 22,197,000 20,422,000 19,883,000 20,401,000 20,169,000 20,552,000 20,442,000 22,019,000 19,698,000 18,244,000 15,571,000 15,418,000 14,009,000 13,883,000 11,955,000 8,902,000 9,265,000 7,499,000 14,528,000 4,645,000 3,901,000 4,331,000 3,162,000 2,174,000 1,891,000 1,064,000 582,000 551,000 488,000 478,000 413,000 408,000 401,000 414,000 375,000 336,000 393,000 373,000 481,000 332,000 611,000 616,000 575,000 548,000 792,000 811,000 836,000 693,000 1,246,000 1,082,000 1,274,000 820,000 972,000 686,000 900,000 219,800 321,900 394,800 371,200 376,500 669,600 
          amortization of premiums and accretion of discounts on investment securities
        		-670,000 -1,102,000 -1,536,000 -2,116,000 -2,817,000 -2,747,000 -1,954,000 -1,786,000 -1,779,000 -1,996,000 -1,491,000 -2,267,000 -2,094,000 -1,189,000 100,000 447,000 638,000 590,000 487,000 689,000 649,000 340,000 394,000 87,000 -561,000 -1,057,000 -989,000 -1,006,000 -163,000    -153,000                                                      
          amortization of intangible assets
        		2,722,000 2,723,000 2,722,000 2,722,000 4,988,000 2,344,000 2,345,000 5,286,000 1,365,000 1,364,000       0 369,000 369,000 370,000 369,000 369,000 369,000 370,000 369,000 369,000 369,000 370,000 369,000 369,000 369,000 369,000 369,000 370,000 369,000 369,000 370,000 369,000                                                 
          gain on sale of non-financial asset
        		                                                                                      
          gain on strategic investment
        		        0   -4,845,000    -339,000                                                                       
          depreciation
        		202,000 227,000 213,000 229,000 226,000 226,000 226,000 242,000 272,000 359,000 402,000 426,000 489,000 506,000 515,000 516,000 535,000 616,000 560,000 525,000 469,000 338,000 354,000 294,000 266,000 282,000 326,000 415,000 413,000 382,000 342,000 392,000 332,000 327,000 307,000 270,000 260,000 241,000 204,000 138,000 128,000 117,000 280,000 122,000  60,000 42,000 43,000     21,000 29,000 29,000 30,000 30,000 30,000    101,000                         
          loss on sale of investment securities
        		        0 19,000 0 505,000                                                                           
          deferred income taxes
        		                                                                                      
          changes in operating assets and liabilities:
        		                                                                                      
          accounts receivable
        		-5,607,000 -8,345,000 -1,762,000 -7,004,000 -530,000 5,489,000 -8,997,000 3,566,000 -5,465,000 -10,950,000 -15,937,000 -3,720,000 -6,462,000 12,220,000 -5,240,000 1,653,000 -3,670,000 -9,329,000 5,465,000 -8,585,000 -1,903,000 -2,559,000 -2,149,000 -5,855,000 -4,977,000 977,000 -1,823,000 -3,868,000 -6,132,000 5,738,000 -3,251,000 -5,102,000 -3,122,000 -2,627,000 -3,934,000 -1,757,000 -2,064,000 -3,546,000                        1,006,000                         
          interest and other receivables
        		-3,192,000 -11,401,000 -4,210,000 -2,015,000 6,198,000 -5,459,000 -1,317,000 -1,295,000 -2,353,000 574,000 2,031,000 -3,450,000 -482,000 533,000 -167,000 209,000 -6,000 -519,000 105,000 1,477,000 -595,000 903,000 592,000 -842,000 -628,000 -524,000 2,871,000 -2,113,000 -975,000 262,000 -83,000 184,000 -54,000 -249,000 1,075,000 -622,000 148,000 -45,000 -557,000 855,000 -1,432,000 1,302,000 -762,000 218,000 175,000 181,000 322,000 -892,000                                       
          inventory
        		-4,892,000 1,248,000 -4,100,000 -10,453,000 -4,424,000 -1,331,000 -27,147,000 -16,648,000 -15,067,000 -11,222,000 -3,000,000 481,000 310,000 640,000 632,000 833,000 217,000 -3,549,000 -386,000 -492,000 -1,649,000 -1,651,000 17,000 -37,000 -1,311,000 -699,000 830,000 -557,000 462,000 682,000 959,000 -177,000 633,000 282,000 -2,128,000 201,000 198,000 -991,000                                                 
          prepaid expenses and other current assets
        		                                6,100,000 -6,513,000   -1,844,000 1,736,000 -2,516,000 -2,107,000 -22,000 -842,000 152,000 -92,000 959,000 954,000                322,000                     -459,500 -140,000 106,400 -284,400 
          operating lease right-of-use assets
        		2,196,000 2,212,000 2,122,000 2,137,000 2,378,000 1,475,000 1,890,000 1,759,000 740,000 1,624,000 1,679,000 1,726,000 1,721,000 1,673,000 1,650,000 1,522,000 1,493,000 1,505,000 1,700,000 1,589,000 1,417,000 838,000 838,000 1,187,000 1,019,000 1,723,000 300,000 833,000                                                           
          other assets
        		-850,000 -700,000 -721,000 -585,000 0    -1,000 83,000   0    -1,000 2,000 -1,000 10,000 132,000 -16,000 48,000 18,000 -59,000 28,000 -35,000 105,000 -347,000 47,000 33,000 31,000 15,000 153,000 146,000 117,000 190,000 136,000 129,000 -911,000 76,000 -72,000 -55,000 9,000 -109,000 -67,000 32,000 36,000 -59,000 -64,000   2,000 4,000 4,000 4,000 64,000 7,000 9,000 26,000 17,000 16,000 -15,000 8,000 29,000 20,000 47,000 -49,000 50,000 11,000 -25,000 47,000 17,000 -112,000 -91,000 159,000 -160,000    -76,100    105,400 -11,100 
          accounts payable
        		-10,844,000 1,650,000 2,002,000 1,903,000 -2,889,000 -801,000 550,000 1,789,000 5,233,000 -6,501,000 1,389,000 4,676,000 2,738,000 -1,846,000 1,086,000 3,892,000 -846,000 -1,343,000 216,000 356,000 5,022,000 -2,995,000 -157,000 -599,000 3,778,000 -1,206,000 1,375,000 108,000 237,000 -333,000 267,000 -5,790,000 5,824,000 -626,000 1,575,000 -1,899,000 1,246,000 1,642,000 -283,000 -365,000 -488,000 -756,000 492,000 408,000 906,000 6,000 -458,000 1,190,000 -748,000 -57,000 -219,000 21,000 244,000 374,000 -277,000 -926,000 699,000 123,000 -249,000 -602,000 -637,000 280,000 182,000 -815,000 404,000 -1,443,000 -212,000 1,907,000 -136,000 -726,000 1,171,000 -585,000 -362,000 632,000 -786,000 -329,000 181,000 -213,000 2,686,000 -1,340,000 343,800 -686,000 1,030,700 -768,000 -365,400 468,300 
          accrued liabilities
        		-68,391,000 27,776,000 21,466,000 -116,000 30,776,000 13,242,000 14,850,000 12,193,000 38,133,000 28,162,000 2,365,000 24,510,000 6,535,000 917,000 -2,818,000 19,672,000 8,805,000 -5,929,000 -14,092,000 2,761,000 9,716,000 6,000,000 -12,204,000 24,057,000 3,157,000 4,877,000 -12,611,000 11,035,000 17,641,000 -7,053,000 2,557,000 2,849,000 7,063,000 -4,110,000 -1,663,000 2,916,000 1,489,000 7,089,000 7,772,000 -771,000 4,685,000 -1,073,000                                             
          operating lease liabilities
        		-2,919,000 -2,179,000 -1,787,000 369,000 195,000 -5,704,000 -2,301,000 212,000 -855,000 -1,675,000 -1,686,000 -1,656,000 -1,957,000 -1,987,000 -1,855,000 -2,117,000 -1,389,000 -1,461,000 -1,531,000 -1,052,000 -1,182,000 275,000 -502,000 -360,000 -448,000 -993,000 -139,000 -938,000                                                           
          long-term liabilities
        		5,248,000 -14,659,000 8,585,000 1,907,000 2,734,000 2,960,000 1,089,000 -3,874,000 2,487,000 3,404,000 3,951,000 -3,769,000 2,608,000 922,000 1,171,000 -2,661,000 2,211,000 -306,000 1,516,000 -1,567,000 1,582,000 -947,000 1,308,000 376,000 687,000 761,000 401,000 -352,000 349,000 183,000 244,000 591,000 -54,000 -17,000 38,000 67,000 -20,000 -20,000 -20,000 -15,000 -7,000 -101,000 122,000 83,000 114,000 3,000 5,000 5,000 6,000                                      
          net cash from operating activities
        		-48,731,000 74,288,000 63,956,000 20,323,000 40,381,000 63,246,000 25,013,000 29,079,000 85,389,000 -58,955,000 8,201,000 -17,933,000 -23,854,000 -727,000 -13,125,000 -76,329,000 -23,120,000 -17,064,000 -25,327,000 -60,149,000 -27,488,000 -22,793,000 -36,883,000 -49,002,000 -29,707,000 -18,851,000 -38,397,000 -64,175,000 -39,079,000 -42,280,000 -40,875,000 -45,236,000 -29,895,000 -58,401,000 -58,900,000 -70,661,000 -63,189,000 -49,262,000 -56,745,000 -41,212,000 -34,722,000 -31,853,000 -29,874,000 -25,346,000 -17,801,000 -17,484,000 -16,967,000 -14,182,000 -10,265,000 -9,475,000 -5,444,000 -6,585,000 -6,297,000 -5,306,000 -4,800,000 -5,230,000 -5,338,000 -4,172,000 -5,280,000 -5,107,000 4,604,000 -2,522,000 -6,333,000 -6,452,000 -8,773,000 -11,661,000 19,995,000 -13,288,000 -12,272,000 -15,843,000 -16,207,000 -20,547,000 -13,868,000 -13,142,000 -13,693,000 -14,223,000 -12,539,000 -12,109,000 -8,805,000 -7,965,000 -7,033,300 -6,264,700 -6,696,800 -267,800 -6,703,500 -5,186,100 
          capital expenditures
        		0 -388,000 0 0 0 0 0 0 0 0 0 0 0 0 0  0 0 -45,000 -1,076,000 0 -1,721,000 -2,933,000 -934,000 -207,000 -80,000 -20,000 -822,000 -570,000 -1,015,000 -115,000 -448,000 -7,000 -56,000 -264,000 -485,000 -249,000 -470,000 -580,000 -207,000 -293,000 -186,000 -674,000 -988,000 -94,000 -80,000 0 -6,000 -128,000 0 0 0 0 0 0 0 0 0 0 0 0 0 0  -17,000 -17,000 -2,000 -5,000 -7,000 -67,000 -75,000 -77,000 -64,000 -157,000 -125,000 -70,000 -680,000 -420,000 -727,000 -199,000 -230,500 -311,300 -389,000 -91,000 -200,100 -84,800 
          free cash flows
        		-48,731,000 73,900,000 63,956,000 20,323,000 40,381,000 63,246,000 25,013,000 29,079,000 85,389,000 -58,955,000 8,201,000 -17,933,000 -23,854,000 -727,000 -13,125,000  -23,120,000 -17,064,000 -25,372,000 -61,225,000 -27,488,000 -24,514,000 -39,816,000 -49,936,000 -29,914,000 -18,931,000 -38,417,000 -64,997,000 -39,649,000 -43,295,000 -40,990,000 -45,684,000 -29,902,000 -58,457,000 -59,164,000 -71,146,000 -63,438,000 -49,732,000 -57,325,000 -41,419,000 -35,015,000 -32,039,000 -30,548,000 -26,334,000 -17,895,000 -17,564,000 -16,967,000 -14,188,000 -10,393,000 -9,475,000 -5,444,000 -6,585,000 -6,297,000 -5,306,000 -4,800,000 -5,230,000 -5,338,000 -4,172,000 -5,280,000 -5,107,000 4,604,000 -2,522,000 -6,333,000  -8,790,000 -11,678,000 19,993,000 -13,293,000 -12,279,000 -15,910,000 -16,282,000 -20,624,000 -13,932,000 -13,299,000 -13,818,000 -14,293,000 -13,219,000 -12,529,000 -9,532,000 -8,164,000 -7,263,800 -6,576,000 -7,085,800 -358,800 -6,903,600 -5,270,900 
          cash flows from investing activities
        		                                                                                      
          purchases of investment securities
        		-157,614,000 -204,553,000 -174,387,000 -156,011,000 -135,762,000 -151,487,000 -137,692,000 -80,154,000 -104,107,000 -37,203,000 -161,783,000 -66,892,000 -93,548,000 -144,249,000   -38,950,000 -251,321,000 -74,662,000 -127,864,000 -239,100,000 5,000 -40,000 -100,773,000 -317,775,000 -84,182,000 -102,732,000 -73,945,000 -232,535,000 -9,617,000 -59,417,000 -26,345,000 -124,978,000 -103,833,000 -109,261,000 -140,746,000 -90,487,000 -266,239,000 -86,063,000 -240,566,000 -53,560,000 -90,671,000 -75,609,000 -49,646,000 -28,150,000 -18,572,000 -137,718,000 -150,921,000 -24,829,000 -24,724,000 -107,165,000 -54,867,000 -41,119,000 -5,771,000 -5,788,000 -4,050,000 -8,252,000 -6,658,000 -8,809,000 -24,347,000 -18,210,000 -11,407,000 -16,951,000 -8,106,000 -11,043,000 -4,013,000 -32,474,000 -2,735,000 -23,883,000 -8,513,000 -20,464,000 -27,112,000 -50,680,000 -57,348,000 -97,222,000 -16,981,000 -42,728,000 -30,628,000 -36,316,000 -6,924,000 -4,384,600 -6,684,400 -31,993,800 -11,459,800 -4,434,900 -3,325,500 
          sale and maturity of investment securities
        		105,750,000 125,589,000 131,390,000 130,800,000 111,850,000 69,100,000 81,500,000 66,115,000 103,760,000 59,110,000 7,500,000 259,410,000                                                                           
          proceeds from sale of non-financial asset
        		                                                                                      
          proceeds from sale of strategic investment
        		                                                                                      
          net purchases of property and equipment
        		                                                                                      
          payment of milestone and contingent payments in connection with asset acquisition
        		                                                                                      
          net cash from investing activities
        		-55,869,000 -79,352,000 -43,294,000 -124,049,000 122,150,000 -82,457,000 -56,192,000 -14,039,000 -347,000 34,110,000 -194,283,000 192,518,000 -17,748,000 15,441,000 -55,797,000 131,345,000 71,549,000 -156,321,000 -17,207,000 30,877,000 -116,958,000 152,994,000 126,865,000 29,608,000 -209,144,000 9,923,000 10,627,000 22,758,000 -188,949,000 31,784,000 -3,942,000 89,618,000 -18,093,000 19,332,000 38,299,000 52,935,000 69,140,000 -154,908,000 -7,460,000 -168,696,000 56,725,000 8,308,000 44,064,000 38,473,000 40,476,000 38,873,000 -67,510,000 -99,112,000 9,541,000 -3,943,000 -98,616,000 -33,086,000 -35,054,000 -2,744,000 8,393,000 3,877,000 3,815,000 4,478,000 6,422,000 -8,735,000 -7,761,000 2,943,000 -2,761,000 6,519,000 8,528,000 10,531,000 -20,805,000 11,190,000 11,534,000 18,169,000 15,376,000 24,635,000 7,174,000 -3,018,000 -66,029,000 19,971,000 967,000 -528,000 -23,979,000 604,000 5,949,900 13,432,300 -23,125,800 -2,907,800 9,608,000 3,089,700 
          cash flows from financing activities
        		                                                                                      
          proceeds from issuance of common stock, net of issuance costs
        		22,666,000 9,423,000 15,956,000 1,838,000 1,969,000 268,000 3,565,000 1,043,000 5,434,000 12,751,000 5,478,000 1,466,000 1,614,000 287,000 3,831,000 2,467,000 4,365,000 1,066,000 5,005,000 7,726,000 18,126,000 11,715,000 47,401,000 3,754,000 43,058,000 319,967,000 4,646,000 4,176,000 300,603,000 211,000 2,953,000 2,880,000 4,791,000 7,897,000 7,010,000 11,490,000  226,077,000 6,438,000 282,991,000  1,132,000 2,599,000 1,439,000  1,282,000 1,720,000 198,042,000   109,871,000 208,000                 40,000 19,000    137,000 97,054,000 923,000    9,098,000    6,956,000 256,000 134,700 
          net cash from financing activities
        		22,666,000 9,423,000 15,956,000 1,838,000 1,969,000 268,000 3,565,000 1,043,000 5,434,000 12,751,000 5,478,000 1,466,000 1,614,000 287,000 3,831,000 2,467,000 4,365,000 1,066,000 5,005,000 7,726,000 18,126,000 11,715,000 47,401,000 3,754,000 43,058,000 319,967,000 4,646,000 4,176,000 300,603,000 211,000 2,953,000 2,880,000 4,791,000 7,897,000 7,010,000 11,490,000 3,986,000 226,077,000 20,758,000 282,991,000 9,332,000 1,132,000 2,599,000 1,439,000 2,807,000 1,282,000 1,720,000 198,042,000 629,000 974,000 109,871,000 208,000 91,233,000 6,860,000 57,000 22,000 97,000 -10,000 47,000 13,810,000 359,000 318,000 -104,000 -103,000 1,077,000 390,000 -91,000 -215,000 -110,000 -218,000 115,000 -161,000 209,000 -77,000 96,998,000 1,090,000 813,000 457,000 59,872,000 8,854,000 -12,466,100 250,000 34,463,800 6,122,500 -306,300 -342,100 
          effect of exchange rate changes on cash
        		7,000 0 24,000 -5,000 -60,000 -42,000 3,000 5,000 -12,000 -4,000 0 -2,000 -8,000 8,000 4,000 2,000 1,000 3,000 -2,000 5,000 -4,000 -5,000 -1,000 2,000 -1,000   1,000 1,000 0 4,000 -2,000 -1,000 -1,000 -3,000 -1,000 4,000   -1,000 4,000 0 -1,000 4,000         1,000    -2,000 1,000 2,000 12,000 -9,000 106,000 -58,000 -19,000 -32,000 78,000 45,000 -18,000 -194,000 -180,000 -4,000 91,000 10,000 68,000 40,000 -3,000 10,000 -11,000 68,000 -25,000 -7,100 122,700 -64,700 -12,700 10,900 -25,400 
          net increase in cash, cash equivalents and restricted cash
        		   -101,893,000    16,088,000 90,464,000 -12,098,000 -180,604,000 176,049,000 -39,996,000   57,485,000 52,795,000 -172,316,000   -126,324,000 141,911,000   -195,794,000 311,042,000 -23,125,000 -37,240,000   -41,860,000 47,260,000                                                       
          cash, cash equivalents and restricted cash
        		                                                                                      
          beginning of year
        		                                                                                      
          end of year
        		                                                                                      
          supplemental disclosure of cash flow information:
        		                                                                                      
          cash paid for income taxes
        		                                                                                      
          supplemental disclosure of noncash information:
        		                                                                                      
          accrued inventory purchases
        		356,000 -3,177,000 3,281,000 759,000 508,000 -746,000 -7,848,000 9,354,000                                                                               
          stock based compensation capitalized
        		193,000 -75,000 214,000 94,000                                                                                   
          accrued milestone and contingent payments in connection with asset acquisition
        		    48,838,000 0 0 50,000,000 0 0 -40,000,000 69,583,000                                                                           
          prepaid expenses
        		 -8,121,000 -44,000 2,978,000  -5,494,000 -3,295,000 -3,670,000  -14,055,000 -263,000 -2,234,000  -2,041,000 4,803,000 -1,863,000  1,584,000 2,309,000 -2,821,000  -5,163,000 -2,720,000 -3,520,000  -2,861,000 5,235,000 -3,015,000  -2,129,000 198,000 -4,563,000    674,000            -73,000                                       
          intangible assets
        		 0 0 -98,838,000     0 0                            0                                                 
          purchases of property and equipment
        		 -388,000                0 -45,000 -1,076,000  -1,721,000 -2,933,000 -934,000 -207,000 -80,000 -20,000 -822,000 -570,000 -1,015,000 -115,000 -448,000 -7,000 -56,000 -264,000 -485,000 -249,000 -470,000 -580,000 -207,000 -293,000 -186,000 -674,000 -988,000 -94,000 -80,000 0 -6,000 -128,000                -17,000 -17,000 -2,000 -5,000 -7,000 -67,000 -75,000 -77,000 -64,000 -157,000 -125,000 -70,000 -680,000 -420,000 -727,000 -199,000 -230,500 -311,300 -389,000 -91,000 -200,100 -84,800 
          net decrease in cash, cash equivalents and restricted cash
        		 4,359,000    -18,985,000              -21,541,000    -15,638,000                                                               
          beginning of period
        		 0 0 328,359,000  0 0 194,427,000  0 0 120,616,000  0 0 153,205,000  0 0 331,798,000 0 0 0 194,467,000 0 0 0 139,584,000 0 0 0 71,893,000  0 0 163,620,000  0 0 102,138,000  0 0 61,854,000  0 0 11,707,000  0 0 57,899,000  0 0 6,889,000  0 0 6,849,000  0 0 18,122,000  0 0 21,171,000  0 0 16,987,000  0 0 15,480,000  0 0 9,796,000  0 0 8,301,700  0 
          end of period
        		 4,359,000 36,642,000 226,466,000  -18,985,000 -27,611,000 210,515,000  -12,098,000 -180,604,000 296,665,000  15,009,000 -65,087,000 210,690,000  -172,316,000 -37,531,000 310,257,000 -126,324,000 141,911,000 137,382,000 178,829,000 -195,794,000 311,042,000 -23,125,000 102,344,000 72,576,000 -10,285,000 -41,860,000 119,153,000  -31,173,000 -13,594,000 157,383,000  21,905,000 -43,446,000 175,220,000  -22,413,000 16,788,000 76,424,000  22,671,000 -82,757,000 96,455,000  -12,444,000 5,811,000 18,436,000  -1,192,000 3,650,000 5,558,000  297,000 1,191,000 6,829,000  845,000 -9,256,000 18,067,000  -662,000 -856,000 18,840,000  1,928,000 -720,000 21,005,000  -16,169,000 17,316,000 22,315,000  -12,191,000 27,156,000 11,264,000  7,540,300 4,576,500 11,235,900  -2,463,900 
          proceeds from sales of strategic investment
        		        0                                                                              
          net loss
        		        45,797,000 -65,176,000 1,114,000 -43,021,000 -41,725,000 -27,183,000 -34,011,000 -113,056,000 -43,094,000 -14,457,000 -43,871,000 -66,448,000          -62,138,000 -63,266,000 -54,296,000                    -6,123,000  -2,402,000 -5,419,000 -6,218,000                               
          adjustments to reconcile net loss to net cash from operating activities:
        		                                                                                      
          loss on strategic investment
        		                -1,623,000 -383,000 -178,000 -145,000   -437,000 1,497,000   12,000 229,000                                                           
          loss on disposal of assets
        		                    0        61,000 -5,000 23,000 9,000     0 0 0 5,000                                               
          non-cash in-process research and development
        		                    0                                                                  
          maturities of investment securities
        		            75,800,000 159,690,000 69,580,000 131,345,000 110,500,000 95,000,000 57,500,000 159,817,000 124,141,000 154,710,000 129,838,000 131,315,000 108,838,000 94,185,000 113,379,000 97,525,000 44,116,000 42,411,000 58,740,000 116,411,000 106,892,000 123,221,000 147,824,000 194,166,000 159,876,000 111,801,000 87,183,000 72,077,000 110,578,000 99,165,000 120,347,000 89,107,000 68,720,000 57,525,000 70,208,000 51,815,000 34,498,000 21,196,000 8,620,000 21,773,000 6,065,000 2,878,000 14,087,000 7,918,000 12,067,000 11,139,000 15,231,000 15,612,000 10,449,000 14,350,000 14,062,000 14,625,000 19,588,000 14,561,000 11,671,000 13,930,000 35,424,000 26,749,000 35,915,000 51,824,000 57,918,000 54,487,000 31,318,000 37,022,000 44,375,000 18,000,000 13,064,000 7,727,000 10,565,000 20,428,000 9,257,000 8,643,000 14,243,000 6,500,000 
          property and equipment purchases in accounts payable and accrued liabilities
        		                   45,000 -796,000 638,000 -981,000 1,269,000 -7,000 24,000 -4,000 21,000 -120,000 -21,000   0 -34,000 -132,000 175,000  33,000 -102,000 356,000                                               
          value of common stock issued in connection with asset acquisition
        		                                                                                      
          common stock issues in connection with merger agreement
        		                                                                                      
          purchases of strategic investments
        		                            1,000 0                                                         
          common stock issued in connection with merger agreement
        		                                                                                      
          (gain) loss on strategic investment
        		                        -491,000                                                              
          deferred revenue
        		                                0 0 -4,132,000 1,488,000 768,000 1,363,000       -15,000 -14,000 -13,000 -13,000 -25,000 -31,000 -29,000 -294,000 168,000 -2,905,000 -13,000 -72,000 107,000 -85,000 224,000 -303,000 -25,969,000 43,000 739,000 -116,000 -1,196,000 -1,593,000 31,314,000 -347,000 269,000 0 0 -537,000    459,000     -722,400 -917,700 -1,756,200 5,521,500 -333,300 -333,400 
          proceeds from sale of property and equipment
        		                            39,000                                                          
          stock-based compensation capitalized in inventory
        		                           57,000 -185,000 -292,000 -113,000 -158,000 -345,000 185,000   72,000 443,000                                                 
          right-of-use assets obtained in exchange for lease obligations
        		                           11,751,000                                                           
          income tax benefit from exercise of stock options
        		                                                                                      
          proceeds from settlement agreement
        		                                    0 0                                                 
          loss on strategic investments
        		                             1,720,000                                                         
          (amortization of premiums) and accretion of discounts on investment securities
        		                              -66,000 -175,000                                                       
          restricted cash
        		                                0 0 0 -100,000 0 0                                                 
          deferred offering costs
        		                                                                                      
          net increase in cash and cash equivalents
        		                                -43,198,000 -31,173,000 -13,594,000 -6,237,000 9,941,000 21,905,000 -43,446,000 73,082,000 31,339,000 -22,413,000 16,788,000 14,570,000 25,485,000 22,671,000 -82,757,000 84,748,000 -96,000 -12,444,000   49,883,000 -1,192,000   -1,428,000 297,000       800,000 -662,000 -856,000 -2,331,000 -1,042,000 1,928,000 -720,000 4,018,000 -6,475,000 -16,169,000 17,316,000 6,835,000 -10,749,000 -12,191,000 27,156,000 1,468,000 -13,556,600 7,540,300 4,576,500 2,934,200 2,609,100 -2,463,900 
          cash and cash equivalents at beginning of period
        		                                                                                      
          cash and cash equivalents at end of period
        		                                                                                      
          cash and cash equivalents
        		                                                                                      
          amortization of premiums and accretion of discounts on investment securities, available for sale
        		                                  -184,000 -113,000 -56,000 368,000 11,000 -234,000 -158,000 -787,000 -826,000 -289,000                                           
          milestone payment for license fee
        		                                                                                      
          proceeds from issuances of equity securities, net of issuance costs
        		                                                                                      
          property and equipment purchases in accrued liabilities
        		                                                                                      
          supplemental disclosure of noncash investing information:
        		                                                                                      
          gain on disposal of assets
        		                                                                                      
          proceeds from sales of property and equipment
        		                                                0   8,000   94,000 9,000                               
          supplemental schedule of noncash investing activities
        		                                                                                      
          accrued expenses
        		                                           42,000 3,690,000 1,922,000 1,777,000 -123,000 -118,000 182,000 2,329,000 20,000 -547,000 -539,000 532,000 1,189,000 -898,000 389,000 -240,000 1,026,000 -542,000 -385,000 -904,000 -304,000 -967,000 -986,000 759,000 -1,088,000 17,000 -1,578,000 -698,000 -4,816,000 3,478,000 2,928,000 -1,536,000 -3,427,000 -384,000 5,854,000 787,000 645,000 2,067,000 1,033,300 -229,900 30,700 377,000 214,200 
          property and equipment purchases in accounts payable and accrued expenses
        		                                           367,000                                           
          depreciation and amortization
        		                                                           189,000    174,000 444,000 219,000 223,000 225,000 229,000 260,000 279,000 275,000 254,000 271,000 274,000 266,000 249,000 219,000 195,000 189,000 206,200 220,800 292,600 306,000 357,300 305,300 
          repayments of long-term debt
        		                                                    -4,000 -9,000 -10,000 -9,000 -9,000 -12,000 -14,000 -43,000 -42,000 -60,000 -144,000 -107,000 -141,000 -184,000 -221,000 -216,000 -150,000 -237,000 -260,000 -262,000 -276,000 -276,000 -303,000 -278,000 -264,000 -266,000 -259,000 -244,000 -249,300 -238,600 -240,700 -833,500 -844,700 -850,200 
          amortization of premiums on investment securities
        		                                             356,000 -322,000 311,000                                       
          other
        		                                                 -23,000 8,000 5,000  -149,000 -94,000 -9,000  22,000 68,000 151,000 202,000 -52,000 -169,000 -75,000 327,000 0 0 -4,000 4,000   -115,000 -49,000 -76,000 -51,000 21,000           
          non-cash charge resulting from lease termination
        		                                                        0 0                             
          gain on sales of property and equipment
        		                                                                                      
          prepaid expenses, receivables and other current assets
        		                                                -75,000 -1,185,000 212,000 -941,000 46,000 -201,000 37,000 438,000 -288,000 40,000 230,000 -113,000    -285,000 473,000 226,000 -124,000 438,000 439,000 543,000 182,000 802,000 -397,000 -896,000 -558,000 63,000    -313,000 664,700      
          unrealized gain on investment securities
        		                                                -35,000             -4,000      -142,000  -94,000 -383,000 135,000  80,000 61,000 -6,000  85,000 43,000 18,000    -32,300 -31,400 3,500 
          amortization of investment securities premium
        		                                                                                      
          proceeds from issuance of common stock and warrants, net of issuance costs
        		                                                    91,237,000 6,869,000 67,000 31,000 106,000   13,853,000                 484,000 70,000   154,500 70,400     
          supplemental schedule of cash flow information
        		                                                                                      
          amortization of investment premium
        		                                                  328,000 145,000 28,000                                  
          proceeds from sales (purchases) of property and equipment
        		                                                    0    0     0                         
          net decrease in cash and cash equivalents
        		                                                   -39,463,000    -1,331,000    -20,000  845,000 -9,256,000 -55,000                       
          other long-term liabilities
        		                                                        -24,000 -23,000 -22,000 -23,000 -21,000 -19,000 -17,000 -33,000 -16,000 -8,000 -19,000 21,000 4,000 -52,000 9,000 38,000 4,000 14,000 8,000 -294,000 -129,000 -281,000 -300,000 641,000 83,600      
          amortization of investment premium/discount
        		                                                      -77,000 -79,000         86,000 21,000 118,000 35,000 267,000 520,000 236,000 -112,000 490,000 -272,000 -654,000 139,000           
          interest paid
        		                                                                                      
          proceeds from issuance of common stock
        		                                                             378,000 40,000 4,000  574,000 130,000 1,000    101,000               
          supplemental schedule of noncash investing and financing activities
        		                                                                                      
          unrealized loss on investment securities
        		                                                               -2,000  -11,000                -26,400     
          proceeds from issuance of long-term debt
        		                                                                        0 62,000 247,000 445,000 593,000 653,000   148,700 418,200   282,400 373,400 
          net property acquired under capital leases
        		                                                                                      
          accrued income from litigation
        		                                                                            0 -9,131,000 194,000 227,000 360,000      
          decrease in restricted cash
        		                                                                                      
          unrealized gain on investment securities, net of tax
        		                                                                                      
          decrease (increase) in restricted cash
        		                                                                                      
          current portion of deferred revenue
        		                                                                         -833,000    -1,125,000 -125,000 595,000       
          property acquired under capital leases
        		                                                                                      
          conversion of debt to common stock
        		                                                                                    0 0 
          conversion of preferred stock to common stock upon initial public offering
        		                                                                                      
          loss on disposal of equipment
        		                                                                             0 27,000 9,000       
          cumulative effect of change in accounting principle
        		                                                                             0 0 -51,000       
          prepaid expenses, receivables and other assets
        		                                                                             2,857,000         
          loss on disposal of property and equipment
        		                                                                                23,000 61,100     
          other noncash expense
        		                                                                                      
          proceeds from issuance of preferred stock, net of issuance costs
        		                                                                                      
          increase in restricted cash
        		                                                                                      
          conversion of convertible preferred stock to common stock upon initial public offering
        		                                                                                    0 0 
          adjustments to reconcile net income to cash from operating activities:
        		                                                                                      
          issuance of stock warrants related to note payable