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cash flows from operating activities
net income	26,666,000	18,987,000	143,742,000	32,765,000	33,389,000	16,555,000	45,797,000	-65,176,000	1,114,000	-43,021,000	-41,725,000	-27,183,000	-34,011,000	-113,056,000	-43,094,000	-14,457,000	-43,871,000	-66,448,000	-66,760,000	-84,660,000	-42,141,000	-88,023,000	-53,036,000	-41,978,000	-54,941,000	-85,304,000	-65,492,000	-62,138,000	-63,266,000	-54,296,000	-68,871,000	-65,248,000	-78,696,000	-71,613,000	-71,322,000	-49,762,000	-45,784,000	-38,906,000	-39,378,000	-40,375,000	-28,366,000	-24,786,000	-21,495,000	-17,828,000	-12,049,000	-10,695,000	-9,081,000	-6,123,000	-6,810,000	-2,402,000	-5,419,000	-6,218,000	-5,300,000	-5,076,000	-6,556,000	-5,833,000	29,141,000	-4,227,000	-4,288,000	-5,487,000	-8,689,000	-8,728,000	-12,727,000	-15,001,000	-13,963,000	-15,614,000	-18,287,000	-16,380,000	-17,039,000	-16,044,000	-10,753,000	-12,554,000	-12,450,000	-11,263,000	-11,868,000	-9,467,000	-10,202,900	-12,306,100	-6,036,900	-5,589,200	-7,334,800	-6,214,600
adjustments to reconcile net income to net cash from operating activities:
stock-based compensation	14,340,000	11,380,000	10,450,000	26,164,000	15,685,000	14,750,000	18,023,000	18,539,000	15,154,000	14,705,000	14,414,000	18,312,000	20,512,000	14,963,000	12,880,000	15,546,000	22,005,000	13,184,000	21,195,000	21,372,000	19,507,000	22,348,000	19,763,000	22,197,000	20,422,000	19,883,000	20,401,000	20,169,000	20,552,000	20,442,000	22,019,000	19,698,000	15,418,000	14,009,000	13,883,000	11,955,000	8,902,000	9,265,000	7,499,000	14,528,000	4,645,000	3,901,000	4,331,000	3,162,000	2,174,000	1,891,000	1,064,000	582,000	551,000	488,000	478,000	413,000	408,000	401,000	414,000	375,000	336,000	393,000	373,000	481,000	332,000	611,000	616,000	575,000	548,000	792,000	811,000	836,000	693,000	1,246,000	1,082,000	1,274,000	820,000	972,000	686,000	900,000	219,800	321,900	394,800	371,200	376,500	669,600
amortization of premiums and accretion of discounts on investment securities	-1,536,000	-2,116,000	-2,817,000	-2,747,000	-1,954,000	-1,786,000	-1,779,000	-1,996,000	-1,491,000	-2,267,000	-2,094,000	-1,189,000	100,000	447,000	638,000	590,000	487,000	689,000	649,000	340,000	394,000	87,000	-561,000	-1,057,000	-989,000	-1,006,000	-163,000				-153,000
amortization of intangible assets	2,722,000	2,722,000	4,988,000	2,344,000	2,345,000	5,286,000	1,365,000	1,364,000							0	369,000	369,000	370,000	369,000	369,000	369,000	370,000	369,000	369,000	369,000	370,000	369,000	369,000	369,000	369,000	369,000	370,000	370,000	369,000
depreciation	213,000	229,000	226,000	226,000	226,000	242,000	272,000	359,000	402,000	426,000	489,000	506,000	515,000	516,000	535,000	616,000	560,000	525,000	469,000	338,000	354,000	294,000	266,000	282,000	326,000	415,000	413,000	382,000	342,000	392,000	332,000	327,000	260,000	241,000	204,000	138,000	128,000	117,000	280,000	122,000		60,000	42,000	43,000					21,000	29,000	29,000	30,000	30,000	30,000				101,000
changes in operating assets and liabilities:
accounts receivable	-1,762,000	-7,004,000	-530,000	5,489,000	-8,997,000	3,566,000	-5,465,000	-10,950,000	-15,937,000	-3,720,000	-6,462,000	12,220,000	-5,240,000	1,653,000	-3,670,000	-9,329,000	5,465,000	-8,585,000	-1,903,000	-2,559,000	-2,149,000	-5,855,000	-4,977,000	977,000	-1,823,000	-3,868,000	-6,132,000	5,738,000	-3,251,000	-5,102,000	-3,122,000	-2,627,000	-2,064,000	-3,546,000																								1,006,000
interest and other receivables	-4,210,000	-2,015,000	6,198,000	-5,459,000	-1,317,000	-1,295,000	-2,353,000	574,000	2,031,000	-3,450,000	-482,000	533,000	-167,000	209,000	-6,000	-519,000	105,000	1,477,000	-595,000	903,000	592,000	-842,000	-628,000	-524,000	2,871,000	-2,113,000	-975,000	262,000	-83,000	184,000	-54,000	-249,000	148,000	-45,000	-557,000	855,000	-1,432,000	1,302,000	-762,000	218,000	175,000	181,000	322,000	-892,000
inventory	-4,100,000	-10,453,000	-4,424,000	-1,331,000	-27,147,000	-16,648,000	-15,067,000	-11,222,000	-3,000,000	481,000	310,000	640,000	632,000	833,000	217,000	-3,549,000	-386,000	-492,000	-1,649,000	-1,651,000	17,000	-37,000	-1,311,000	-699,000	830,000	-557,000	462,000	682,000	959,000	-177,000	633,000	282,000	198,000	-991,000
prepaid expenses	-44,000	2,978,000		-5,494,000	-3,295,000	-3,670,000		-14,055,000	-263,000	-2,234,000		-2,041,000	4,803,000	-1,863,000		1,584,000	2,309,000	-2,821,000		-5,163,000	-2,720,000	-3,520,000		-2,861,000	5,235,000	-3,015,000		-2,129,000	198,000	-4,563,000														-73,000
other assets	-721,000	-585,000	0				-1,000	83,000			0				-1,000	2,000	-1,000	10,000	132,000	-16,000	48,000	18,000	-59,000	28,000	-35,000	105,000	-347,000	47,000	33,000	31,000	15,000	153,000	190,000	136,000	129,000	-911,000	76,000	-72,000	-55,000	9,000	-109,000	-67,000	32,000	36,000	-59,000	-64,000			2,000	4,000	4,000	4,000	64,000	7,000	9,000	26,000	17,000	16,000	-15,000	8,000	29,000	20,000	47,000	-49,000	50,000	11,000	-25,000	47,000	17,000	-112,000	-91,000	159,000	-160,000				-76,100				105,400	-11,100
operating lease right-of-use assets	2,122,000	2,137,000	2,378,000	1,475,000	1,890,000	1,759,000	740,000	1,624,000	1,679,000	1,726,000	1,721,000	1,673,000	1,650,000	1,522,000	1,493,000	1,505,000	1,700,000	1,589,000	1,417,000	838,000	838,000	1,187,000	1,019,000	1,723,000	300,000	833,000
accounts payable	2,002,000	1,903,000	-2,889,000	-801,000	550,000	1,789,000	5,233,000	-6,501,000	1,389,000	4,676,000	2,738,000	-1,846,000	1,086,000	3,892,000	-846,000	-1,343,000	216,000	356,000	5,022,000	-2,995,000	-157,000	-599,000	3,778,000	-1,206,000	1,375,000	108,000	237,000	-333,000	267,000	-5,790,000	5,824,000	-626,000	1,246,000	1,642,000	-283,000	-365,000	-488,000	-756,000	492,000	408,000	906,000	6,000	-458,000	1,190,000	-748,000	-57,000	-219,000	21,000	244,000	374,000	-277,000	-926,000	699,000	123,000	-249,000	-602,000	-637,000	280,000	182,000	-815,000	404,000	-1,443,000	-212,000	1,907,000	-136,000	-726,000	1,171,000	-585,000	-362,000	632,000	-786,000	-329,000	181,000	-213,000	2,686,000	-1,340,000	343,800	-686,000	1,030,700	-768,000	-365,400	468,300
accrued liabilities	21,466,000	-116,000	30,776,000	13,242,000	14,850,000	12,193,000	38,133,000	28,162,000	2,365,000	24,510,000	6,535,000	917,000	-2,818,000	19,672,000	8,805,000	-5,929,000	-14,092,000	2,761,000	9,716,000	6,000,000	-12,204,000	24,057,000	3,157,000	4,877,000	-12,611,000	11,035,000	17,641,000	-7,053,000	2,557,000	2,849,000	7,063,000	-4,110,000	1,489,000	7,089,000	7,772,000	-771,000	4,685,000	-1,073,000
operating lease liabilities	-1,787,000	369,000	195,000	-5,704,000	-2,301,000	212,000	-855,000	-1,675,000	-1,686,000	-1,656,000	-1,957,000	-1,987,000	-1,855,000	-2,117,000	-1,389,000	-1,461,000	-1,531,000	-1,052,000	-1,182,000	275,000	-502,000	-360,000	-448,000	-993,000	-139,000	-938,000
long-term liabilities	8,585,000	1,907,000	2,734,000	2,960,000	1,089,000	-3,874,000	2,487,000	3,404,000	3,951,000	-3,769,000	2,608,000	922,000	1,171,000	-2,661,000	2,211,000	-306,000	1,516,000	-1,567,000	1,582,000	-947,000	1,308,000	376,000	687,000	761,000	401,000	-352,000	349,000	183,000	244,000	591,000	-54,000	-17,000	-20,000	-20,000	-20,000	-15,000	-7,000	-101,000	122,000	83,000	114,000	3,000	5,000	5,000	6,000
net cash from operating activities	63,956,000	20,323,000	40,381,000	63,246,000	25,013,000	29,079,000	85,389,000	-58,955,000	8,201,000	-17,933,000	-23,854,000	-727,000	-13,125,000	-76,329,000	-23,120,000	-17,064,000	-25,327,000	-60,149,000	-27,488,000	-22,793,000	-36,883,000	-49,002,000	-29,707,000	-18,851,000	-38,397,000	-64,175,000	-39,079,000	-42,280,000	-40,875,000	-45,236,000	-29,895,000	-58,401,000	-63,189,000	-49,262,000	-56,745,000	-41,212,000	-34,722,000	-31,853,000	-29,874,000	-25,346,000	-17,801,000	-17,484,000	-16,967,000	-14,182,000	-10,265,000	-9,475,000	-5,444,000	-6,585,000	-6,297,000	-5,306,000	-4,800,000	-5,230,000	-5,338,000	-4,172,000	-5,280,000	-5,107,000	4,604,000	-2,522,000	-6,333,000	-6,452,000	-8,773,000	-11,661,000	19,995,000	-13,288,000	-12,272,000	-15,843,000	-16,207,000	-20,547,000	-13,868,000	-13,142,000	-13,693,000	-14,223,000	-12,539,000	-12,109,000	-8,805,000	-7,965,000	-7,033,300	-6,264,700	-6,696,800	-267,800	-6,703,500	-5,186,100
capex	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	-45,000	-1,076,000	0	-1,721,000	-2,933,000	-934,000	-207,000	-80,000	-20,000	-822,000	-570,000	-1,015,000	-115,000	-448,000	-7,000	-56,000	-249,000	-470,000	-580,000	-207,000	-293,000	-186,000	-674,000	-988,000	-94,000	-80,000	0	-6,000	-128,000	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	-17,000	-17,000	-2,000	-5,000	-7,000	-67,000	-75,000	-77,000	-64,000	-157,000	-125,000	-70,000	-680,000	-420,000	-727,000	-199,000	-230,500	-311,300	-389,000	-91,000	-200,100	-84,800
free cash flows	63,956,000	20,323,000	40,381,000	63,246,000	25,013,000	29,079,000	85,389,000	-58,955,000	8,201,000	-17,933,000	-23,854,000	-727,000	-13,125,000	-76,329,000	-23,120,000	-17,064,000	-25,372,000	-61,225,000	-27,488,000	-24,514,000	-39,816,000	-49,936,000	-29,914,000	-18,931,000	-38,417,000	-64,997,000	-39,649,000	-43,295,000	-40,990,000	-45,684,000	-29,902,000	-58,457,000	-63,438,000	-49,732,000	-57,325,000	-41,419,000	-35,015,000	-32,039,000	-30,548,000	-26,334,000	-17,895,000	-17,564,000	-16,967,000	-14,188,000	-10,393,000	-9,475,000	-5,444,000	-6,585,000	-6,297,000	-5,306,000	-4,800,000	-5,230,000	-5,338,000	-4,172,000	-5,280,000	-5,107,000	4,604,000	-2,522,000	-6,333,000	-6,452,000	-8,790,000	-11,678,000	19,993,000	-13,293,000	-12,279,000	-15,910,000	-16,282,000	-20,624,000	-13,932,000	-13,299,000	-13,818,000	-14,293,000	-13,219,000	-12,529,000	-9,532,000	-8,164,000	-7,263,800	-6,576,000	-7,085,800	-358,800	-6,903,600	-5,270,900
cash flows from investing activities
purchases of investment securities	-174,387,000	-156,011,000	-135,762,000	-151,487,000	-137,692,000	-80,154,000	-104,107,000	-37,203,000	-161,783,000	-66,892,000	-93,548,000	-144,249,000			-38,950,000	-251,321,000	-74,662,000	-127,864,000	-239,100,000	5,000	-40,000	-100,773,000	-317,775,000	-84,182,000	-102,732,000	-73,945,000	-232,535,000	-9,617,000	-59,417,000	-26,345,000	-124,978,000	-103,833,000	-90,487,000	-266,239,000	-86,063,000	-240,566,000	-53,560,000	-90,671,000	-75,609,000	-49,646,000	-28,150,000	-18,572,000	-137,718,000	-150,921,000	-24,829,000	-24,724,000	-107,165,000	-54,867,000	-41,119,000	-5,771,000	-5,788,000	-4,050,000	-8,252,000	-6,658,000	-8,809,000	-24,347,000	-18,210,000	-11,407,000	-16,951,000	-8,106,000	-11,043,000	-4,013,000	-32,474,000	-2,735,000	-23,883,000	-8,513,000	-20,464,000	-27,112,000	-50,680,000	-57,348,000	-97,222,000	-16,981,000	-42,728,000	-30,628,000	-36,316,000	-6,924,000	-4,384,600	-6,684,400	-31,993,800	-11,459,800	-4,434,900	-3,325,500
sale and maturity of investment securities	131,390,000	130,800,000	111,850,000	69,100,000	81,500,000	66,115,000	103,760,000	59,110,000	7,500,000	259,410,000
intangible assets	0	-98,838,000					0	0																										0
purchases of property and equipment																0	-45,000	-1,076,000		-1,721,000	-2,933,000	-934,000	-207,000	-80,000	-20,000	-822,000	-570,000	-1,015,000	-115,000	-448,000	-7,000	-56,000	-249,000	-470,000	-580,000	-207,000	-293,000	-186,000	-674,000	-988,000	-94,000	-80,000	0	-6,000	-128,000																-17,000	-17,000	-2,000	-5,000	-7,000	-67,000	-75,000	-77,000	-64,000	-157,000	-125,000	-70,000	-680,000	-420,000	-727,000	-199,000	-230,500	-311,300	-389,000	-91,000	-200,100	-84,800
net cash from investing activities	-43,294,000	-124,049,000	122,150,000	-82,457,000	-56,192,000	-14,039,000	-347,000	34,110,000	-194,283,000	192,518,000	-17,748,000	15,441,000	-55,797,000	131,345,000	71,549,000	-156,321,000	-17,207,000	30,877,000	-116,958,000	152,994,000	126,865,000	29,608,000	-209,144,000	9,923,000	10,627,000	22,758,000	-188,949,000	31,784,000	-3,942,000	89,618,000	-18,093,000	19,332,000	69,140,000	-154,908,000	-7,460,000	-168,696,000	56,725,000	8,308,000	44,064,000	38,473,000	40,476,000	38,873,000	-67,510,000	-99,112,000	9,541,000	-3,943,000	-98,616,000	-33,086,000	-35,054,000	-2,744,000	8,393,000	3,877,000	3,815,000	4,478,000	6,422,000	-8,735,000	-7,761,000	2,943,000	-2,761,000	6,519,000	8,528,000	10,531,000	-20,805,000	11,190,000	11,534,000	18,169,000	15,376,000	24,635,000	7,174,000	-3,018,000	-66,029,000	19,971,000	967,000	-528,000	-23,979,000	604,000	5,949,900	13,432,300	-23,125,800	-2,907,800	9,608,000	3,089,700
cash flows from financing activities
proceeds from issuance of common stock, net of issuance costs	15,956,000	1,838,000	1,969,000	268,000	3,565,000	1,043,000	5,434,000	12,751,000	5,478,000	1,466,000	1,614,000	287,000	3,831,000	2,467,000	4,365,000	1,066,000	5,005,000	7,726,000	18,126,000	11,715,000	47,401,000	3,754,000	43,058,000	319,967,000	4,646,000	4,176,000	300,603,000	211,000	2,953,000	2,880,000	4,791,000	7,897,000		226,077,000	6,438,000	282,991,000		1,132,000	2,599,000	1,439,000		1,282,000	1,720,000	198,042,000			109,871,000	208,000																	40,000	19,000				137,000	97,054,000	923,000				9,098,000				6,956,000	256,000	134,700
net cash from financing activities	15,956,000	1,838,000	1,969,000	268,000	3,565,000	1,043,000	5,434,000	12,751,000	5,478,000	1,466,000	1,614,000	287,000	3,831,000	2,467,000	4,365,000	1,066,000	5,005,000	7,726,000	18,126,000	11,715,000	47,401,000	3,754,000	43,058,000	319,967,000	4,646,000	4,176,000	300,603,000	211,000	2,953,000	2,880,000	4,791,000	7,897,000	3,986,000	226,077,000	20,758,000	282,991,000	9,332,000	1,132,000	2,599,000	1,439,000	2,807,000	1,282,000	1,720,000	198,042,000	629,000	974,000	109,871,000	208,000	91,233,000	6,860,000	57,000	22,000	97,000	-10,000	47,000	13,810,000	359,000	318,000	-104,000	-103,000	1,077,000	390,000	-91,000	-215,000	-110,000	-218,000	115,000	-161,000	209,000	-77,000	96,998,000	1,090,000	813,000	457,000	59,872,000	8,854,000	-12,466,100	250,000	34,463,800	6,122,500	-306,300	-342,100
effect of exchange rate changes on cash	24,000	-5,000	-60,000	-42,000	3,000	5,000	-12,000	-4,000	0	-2,000	-8,000	8,000	4,000	2,000	1,000	3,000	-2,000	5,000	-4,000	-5,000	-1,000	2,000	-1,000			1,000	1,000	0	4,000	-2,000	-1,000	-1,000	4,000			-1,000	4,000	0	-1,000	4,000									1,000				-2,000	1,000	2,000	12,000	-9,000	106,000	-58,000	-19,000	-32,000	78,000	45,000	-18,000	-194,000	-180,000	-4,000	91,000	10,000	68,000	40,000	-3,000	10,000	-11,000	68,000	-25,000	-7,100	122,700	-64,700	-12,700	10,900	-25,400
net decrease in cash, cash equivalents and restricted cash				-18,985,000														-21,541,000				-15,638,000
cash, cash equivalents and restricted cash
beginning of period	0	328,359,000		0	0	194,427,000		0	0	120,616,000		0	0	153,205,000		0	0	331,798,000	0	0	0	194,467,000	0	0	0	139,584,000	0	0	0	71,893,000		0		0	0	102,138,000		0	0	61,854,000		0	0	11,707,000		0	0	57,899,000		0	0	6,889,000		0	0	6,849,000		0	0	18,122,000		0	0	21,171,000		0	0	16,987,000		0	0	15,480,000		0	0	9,796,000		0	0	8,301,700		0
end of period	36,642,000	226,466,000		-18,985,000	-27,611,000	210,515,000		-12,098,000	-180,604,000	296,665,000		15,009,000	-65,087,000	210,690,000		-172,316,000	-37,531,000	310,257,000	-126,324,000	141,911,000	137,382,000	178,829,000	-195,794,000	311,042,000	-23,125,000	102,344,000	72,576,000	-10,285,000	-41,860,000	119,153,000		-31,173,000		21,905,000	-43,446,000	175,220,000		-22,413,000	16,788,000	76,424,000		22,671,000	-82,757,000	96,455,000		-12,444,000	5,811,000	18,436,000		-1,192,000	3,650,000	5,558,000		297,000	1,191,000	6,829,000		845,000	-9,256,000	18,067,000		-662,000	-856,000	18,840,000		1,928,000	-720,000	21,005,000		-16,169,000	17,316,000	22,315,000		-12,191,000	27,156,000	11,264,000		7,540,300	4,576,500	11,235,900		-2,463,900
supplemental disclosure of noncash information:
accrued inventory purchases	3,281,000	759,000	508,000	-746,000	-7,848,000	9,354,000
accrued milestone and contingent payments in connection with asset acquisition			48,838,000	0	0	50,000,000	0	0	-40,000,000	69,583,000
stock based compensation capitalized	214,000	94,000
net increase in cash, cash equivalents and restricted cash		-101,893,000				16,088,000	90,464,000	-12,098,000	-180,604,000	176,049,000	-39,996,000			57,485,000	52,795,000	-172,316,000			-126,324,000	141,911,000			-195,794,000	311,042,000	-23,125,000	-37,240,000			-41,860,000	47,260,000
gain on sale of non-financial asset
gain on strategic investment							0			-4,845,000		-2,156,000	497,000	-339,000					-265,000
loss on sale of investment securities							0	19,000	0	505,000
prepaid expenses and other current assets																															6,100,000	-6,513,000	-1,844,000	1,736,000	-2,516,000	-2,107,000	-22,000	-842,000	152,000	-92,000	959,000	954,000																322,000																					-459,500	-140,000	106,400	-284,400
proceeds from sale of non-financial asset
proceeds from sale of strategic investment
net purchases of property and equipment
beginning of year
end of year
supplemental disclosure of cash flow information:
cash paid for income taxes
proceeds from sales of strategic investment							0
(gain) loss on strategic investment															-1,623,000	-383,000	-178,000	-145,000					-491,000
loss on disposal of assets																			0								61,000	-5,000	23,000	9,000			0	0	0	5,000
non-cash in-process research and development																			0
maturities of investment securities											75,800,000	159,690,000	69,580,000	131,345,000	110,500,000	95,000,000	57,500,000	159,817,000	124,141,000	154,710,000	129,838,000	131,315,000	108,838,000	94,185,000	113,379,000	97,525,000	44,116,000	42,411,000	58,740,000	116,411,000	106,892,000	123,221,000	159,876,000	111,801,000	87,183,000	72,077,000	110,578,000	99,165,000	120,347,000	89,107,000	68,720,000	57,525,000	70,208,000	51,815,000	34,498,000	21,196,000	8,620,000	21,773,000	6,065,000	2,878,000	14,087,000	7,918,000	12,067,000	11,139,000	15,231,000	15,612,000	10,449,000	14,350,000	14,062,000	14,625,000	19,588,000	14,561,000	11,671,000	13,930,000	35,424,000	26,749,000	35,915,000	51,824,000	57,918,000	54,487,000	31,318,000	37,022,000	44,375,000	18,000,000	13,064,000	7,727,000	10,565,000	20,428,000	9,257,000	8,643,000	14,243,000	6,500,000
property and equipment purchases in accounts payable and accrued liabilities																		45,000	-796,000	638,000	-981,000	1,269,000	-7,000	24,000	-4,000	21,000	-120,000	-21,000			0	-34,000		33,000	-102,000	356,000
value of common stock issued in connection with asset acquisition
common stock issues in connection with merger agreement
purchases of strategic investments																											1,000	0
common stock issued in connection with merger agreement
loss on strategic investment																					-437,000	1,497,000			12,000	229,000
deferred revenue																															0	0	768,000	1,363,000							-15,000	-14,000	-13,000	-13,000	-25,000	-31,000	-29,000	-294,000	168,000	-2,905,000	-13,000	-72,000	107,000	-85,000	224,000	-303,000	-25,969,000	43,000	739,000	-116,000	-1,196,000	-1,593,000	31,314,000	-347,000	269,000	0	0	-537,000				459,000					-722,400	-917,700	-1,756,200	5,521,500	-333,300	-333,400
proceeds from sale of property and equipment																											39,000
stock-based compensation capitalized in inventory																										57,000	-185,000	-292,000	-113,000	-158,000	-345,000	185,000	72,000	443,000
right-of-use assets obtained in exchange for lease obligations																										11,751,000
income tax benefit from exercise of stock options
proceeds from settlement agreement																																	0	0
loss on strategic investments																												1,720,000
(amortization of premiums) and accretion of discounts on investment securities																													-66,000	-175,000
restricted cash																															0	0	0	0
deferred offering costs
net increase in cash and cash equivalents																															-43,198,000	-31,173,000	9,941,000	21,905,000	-43,446,000	73,082,000	31,339,000	-22,413,000	16,788,000	14,570,000	25,485,000	22,671,000	-82,757,000	84,748,000	-96,000	-12,444,000			49,883,000	-1,192,000			-1,428,000	297,000							800,000	-662,000	-856,000	-2,331,000	-1,042,000	1,928,000	-720,000	4,018,000	-6,475,000	-16,169,000	17,316,000	6,835,000	-10,749,000	-12,191,000	27,156,000	1,468,000	-13,556,600	7,540,300	4,576,500	2,934,200	2,609,100	-2,463,900
cash and cash equivalents at beginning of period
cash and cash equivalents at end of period
cash and cash equivalents
amortization of premiums and accretion of discounts on investment securities, available for sale																																	-56,000	368,000	11,000	-234,000	-158,000	-787,000	-826,000	-289,000
milestone payment for license fee
proceeds from issuances of equity securities, net of issuance costs
property and equipment purchases in accrued liabilities
supplemental disclosure of noncash investing information:
gain on disposal of assets
proceeds from sales of property and equipment																																													0			8,000			94,000	9,000
supplemental schedule of noncash investing activities
accrued expenses																																								42,000	3,690,000	1,922,000	1,777,000	-123,000	-118,000	182,000	2,329,000	20,000	-547,000	-539,000	532,000	1,189,000	-898,000	389,000	-240,000	1,026,000	-542,000	-385,000	-904,000	-304,000	-967,000	-986,000	759,000	-1,088,000	17,000	-1,578,000	-698,000	-4,816,000	3,478,000	2,928,000	-1,536,000	-3,427,000	-384,000	5,854,000	787,000	645,000	2,067,000	1,033,300	-229,900	30,700	377,000	214,200
property and equipment purchases in accounts payable and accrued expenses																																								367,000
depreciation and amortization																																																								189,000				174,000	444,000	219,000	223,000	225,000	229,000	260,000	279,000	275,000	254,000	271,000	274,000	266,000	249,000	219,000	195,000	189,000	206,200	220,800	292,600	306,000	357,300	305,300
repayments of long-term debt																																																	-4,000	-9,000	-10,000	-9,000	-9,000	-12,000	-14,000	-43,000	-42,000	-60,000	-144,000	-107,000	-141,000	-184,000	-221,000	-216,000	-150,000	-237,000	-260,000	-262,000	-276,000	-276,000	-303,000	-278,000	-264,000	-266,000	-259,000	-244,000	-249,300	-238,600	-240,700	-833,500	-844,700	-850,200
amortization of premiums on investment securities																																										356,000	-322,000	311,000
other																																														-23,000	8,000	5,000		-149,000	-94,000	-9,000		22,000	68,000	151,000	202,000	-52,000	-169,000	-75,000	327,000	0	0	-4,000	4,000			-115,000	-49,000	-76,000	-51,000	21,000
non-cash charge resulting from lease termination																																																					0	0
gain on sales of property and equipment
prepaid expenses, receivables and other current assets																																													-75,000	-1,185,000	212,000	-941,000	46,000	-201,000	37,000	438,000	-288,000	40,000	230,000	-113,000				-285,000	473,000	226,000	-124,000	438,000	439,000	543,000	182,000	802,000	-397,000	-896,000	-558,000	63,000				-313,000	664,700
unrealized gain on investment securities																																													-35,000													-4,000						-142,000		-94,000	-383,000	135,000		80,000	61,000	-6,000		85,000	43,000	18,000				-32,300	-31,400	3,500
amortization of investment securities premium
proceeds from issuance of common stock and warrants, net of issuance costs																																																	91,237,000	6,869,000	67,000	31,000	106,000			13,853,000																	484,000	70,000			154,500	70,400
supplemental schedule of cash flow information
amortization of investment premium																																															328,000	145,000	28,000
proceeds from sales (purchases) of property and equipment																																																	0				0					0
net decrease in cash and cash equivalents																																																-39,463,000				-1,331,000				-20,000		845,000	-9,256,000	-55,000
other long-term liabilities																																																					-24,000	-23,000	-22,000	-23,000	-21,000	-19,000	-17,000	-33,000	-16,000	-8,000	-19,000	21,000	4,000	-52,000	9,000	38,000	4,000	14,000	8,000	-294,000	-129,000	-281,000	-300,000	641,000	83,600
amortization of investment premium/discount																																																			-77,000	-79,000									86,000	21,000	118,000	35,000	267,000	520,000	236,000	-112,000	490,000	-272,000	-654,000	139,000
interest paid
proceeds from issuance of common stock																																																										378,000	40,000	4,000		574,000	130,000	1,000				101,000
supplemental schedule of noncash investing and financing activities
unrealized loss on investment securities																																																												-2,000		-11,000																-26,400
proceeds from issuance of long-term debt																																																																					0	62,000	247,000	445,000	593,000	653,000			148,700	418,200			282,400	373,400
net property acquired under capital leases
accrued income from litigation																																																																									0	-9,131,000	194,000	227,000	360,000
decrease in restricted cash
unrealized gain on investment securities, net of tax
decrease (increase) in restricted cash
current portion of deferred revenue																																																																						-833,000				-1,125,000	-125,000	595,000
property acquired under capital leases
conversion of debt to common stock																																																																																	0	0
conversion of preferred stock to common stock upon initial public offering
loss on disposal of equipment																																																																										0	27,000	9,000
cumulative effect of change in accounting principle																																																																										0	0	-51,000
prepaid expenses, receivables and other assets																																																																										2,857,000
loss on disposal of property and equipment																																																																													23,000	61,100
other noncash expense
proceeds from issuance of preferred stock, net of issuance costs
increase in restricted cash
conversion of convertible preferred stock to common stock upon initial public offering																																																																																	0	0
adjustments to reconcile net income to cash from operating activities:
issuance of stock warrants related to note payable

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