Quarterly
Annual
| Unit: USD | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-12-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-12-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-12-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 | 2013-12-31 | 2013-09-30 | 2013-06-30 | 2013-03-31 | 2012-12-31 | 2012-09-30 | 2012-06-30 | 2012-03-31 | 2011-12-31 | 2011-09-30 | 2011-06-30 | 2011-03-31 | 2010-12-31 | 2010-09-30 | 2010-06-30 | 2010-03-31 | 2009-12-31 | 2009-09-30 | 2009-06-30 | 2009-03-31 | 2008-12-31 | 2008-09-30 | 2008-06-30 | 2008-03-31 | 2007-12-31 | 2007-09-30 | 2007-06-30 | 2007-03-31 | 2006-12-31 | 2006-09-30 | 2006-06-30 | 2006-03-31 | 2005-12-31 | 2005-09-30 | 2005-06-30 | 2005-03-31 | 2004-12-31 | 2004-09-30 | 2004-06-30 | 
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
  revenues  | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  product sales  | 264,566,000 | 244,317,000 | 259,602,000 | 250,401,000 | 241,963,000 | 205,831,000 | 231,041,000 | 211,699,000 | 165,235,000 | 118,462,000 | 136,490,000 | 130,714,000 | 134,563,000 | 115,468,000 | 130,758,000 | 131,612,000 | 115,221,000 | 106,554,000 | 121,007,000 | 120,577,000 | 110,103,000 | 90,068,000 | 98,326,000 | 94,586,000 | 83,205,000 | 62,959,000 | 59,571,000 | 58,305,000 | 57,063,000 | 48,868,000 | 43,562,000 | 35,578,000 | 30,475,000 | 15,286,000 | 11,962,000 | 5,268,000 | 97,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
  total revenues  | 264,566,000 | 244,317,000 | 259,602,000 | 250,401,000 | 241,963,000 | 205,831,000 | 231,041,000 | 211,699,000 | 165,235,000 | 118,462,000 | 136,490,000 | 130,714,000 | 134,563,000 | 115,468,000 | 130,758,000 | 131,612,000 | 115,221,000 | 106,554,000 | 121,007,000 | 120,577,000 | 110,103,000 | 90,068,000 | 98,326,000 | 94,586,000 | 83,205,000 | 62,959,000 | 59,571,000 | 58,305,000 | 57,063,000 | 48,868,000 | 43,562,000 | 35,578,000 | 30,475,000 | 15,286,000 | 11,962,000 | 5,268,000 | 97,000 | 1,083,400 | 1,581,300 | 1,015,700 | |||||||||||||||||||||||||||||||||||||||||||||
  operating expenses  | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  cost of product sales  | 20,734,000 | 20,392,000 | 21,803,000 | 18,857,000 | 18,230,000 | 22,951,000 | 17,891,000 | 14,622,000 | 7,459,000 | 1,667,000 | 2,413,000 | 2,136,000 | 2,667,000 | 2,950,000 | 2,444,000 | 3,688,000 | 2,526,000 | 2,185,000 | 2,508,000 | 2,005,000 | 2,899,000 | 2,799,000 | 3,020,000 | 2,416,000 | 2,958,000 | 2,950,000 | 2,823,000 | 3,839,000 | 3,562,000 | 2,153,000 | 2,455,000 | 2,135,000 | 2,224,000 | 2,263,000 | 1,704,000 | 845,000 | 526,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
  research and development  | 77,951,000 | 78,265,000 | 100,731,000 | 66,606,000 | 76,233,000 | 59,679,000 | 66,741,000 | 156,963,000 | 58,771,000 | 69,144,000 | 75,738,000 | 81,336,000 | 75,646,000 | 128,855,000 | 66,942,000 | 58,565,000 | 56,935,000 | 56,973,000 | 62,116,000 | 120,083,000 | 64,295,000 | 72,636,000 | 57,520,000 | 62,622,000 | 67,320,000 | 52,923,000 | 48,183,000 | 53,112,000 | 46,592,000 | 39,276,000 | 43,179,000 | 36,421,000 | 34,180,000 | 35,409,000 | 30,218,000 | 25,813,000 | 20,478,000 | 22,775,000 | 20,466,000 | 18,729,000 | 18,379,000 | 16,295,000 | 18,182,000 | 16,952,000 | 13,799,000 | 11,668,000 | 7,925,000 | 7,254,000 | 7,112,000 | 4,430,000 | 4,901,000 | 4,400,000 | 4,472,000 | 5,021,000 | 4,424,000 | 4,158,000 | 4,315,000 | 4,412,000 | 4,757,000 | 4,965,000 | 5,041,000 | 5,815,000 | 7,836,000 | 9,215,000 | 11,979,000 | 12,554,000 | 12,146,000 | 13,397,000 | 16,036,000 | 15,171,000 | 17,278,000 | 16,909,000 | 11,495,000 | 12,261,000 | 10,919,000 | 16,099,000 | 12,255,000 | 10,126,000 | 10,104,300 | 8,064,900 | 6,563,100 | 6,115,600 | 6,374,900 | 5,923,200 | 5,406,600 | 
  selling, general and administrative  | 133,507,000 | 126,370,000 | 130,080,000 | 133,294,000 | 117,063,000 | 107,991,000 | 111,465,000 | 97,890,000 | 95,968,000 | 101,235,000 | 104,402,000 | 78,108,000 | 89,901,000 | 96,679,000 | 105,912,000 | 81,666,000 | 96,789,000 | 111,661,000 | 120,752,000 | 81,592,000 | 84,344,000 | 101,973,000 | 91,871,000 | 72,696,000 | 67,981,000 | 93,090,000 | 74,271,000 | 61,089,000 | 69,472,000 | 60,926,000 | 65,539,000 | 62,255,000 | 61,523,000 | 65,745,000 | 57,663,000 | 50,534,000 | 50,768,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
  total operating expenses  | 232,192,000 | 225,027,000 | 106,099,000 | 218,757,000 | 211,526,000 | 190,621,000 | 196,097,000 | 269,475,000 | 162,198,000 | 172,046,000 | 182,553,000 | 161,580,000 | 168,214,000 | 228,484,000 | 175,415,000 | 146,913,000 | 158,930,000 | 173,326,000 | 188,169,000 | 206,476,000 | 154,113,000 | 179,583,000 | 154,725,000 | 140,007,000 | 140,296,000 | 150,593,000 | 126,846,000 | 119,576,000 | 121,142,000 | 103,687,000 | 112,421,000 | 101,889,000 | 98,909,000 | 104,092,000 | 90,193,000 | 77,667,000 | 72,020,000 | 50,266,000 | 45,582,000 | 39,037,000 | 39,498,000 | 40,556,000 | 28,602,000 | 25,009,000 | 21,751,000 | 17,988,000 | 12,201,000 | 11,051,000 | 9,608,000 | 6,581,000 | 7,199,000 | 5,885,000 | 6,028,000 | 6,681,000 | 5,902,000 | 5,677,000 | 7,044,000 | 6,296,000 | 6,275,000 | 6,543,000 | 6,593,000 | 7,629,000 | 10,475,000 | 11,209,000 | 14,641,000 | 15,542,000 | 14,536,000 | 16,371,000 | 19,220,000 | 18,441,000 | 20,288,000 | 19,850,000 | 14,658,000 | 15,413,000 | 15,323,000 | 14,482,000 | 14,745,000 | 12,637,000 | 13,142,900 | 16,486,000 | 9,008,300 | 8,125,400 | 8,538,800 | 7,903,800 | 6,901,000 | 
  income from operations  | 32,374,000 | 19,290,000 | 153,503,000 | 31,644,000 | 30,437,000 | 15,210,000 | 34,944,000 | -57,776,000 | 3,037,000 | -53,584,000 | -46,063,000 | -30,866,000 | -33,651,000 | -113,016,000 | -44,657,000 | -15,301,000 | -43,709,000 | -66,772,000 | -67,162,000 | -85,899,000 | -44,010,000 | -89,515,000 | -56,399,000 | -45,421,000 | -57,091,000 | -87,634,000 | -67,275,000 | -61,271,000 | -64,079,000 | -54,819,000 | -68,859,000 | -66,311,000 | -68,434,000 | -88,806,000 | -78,231,000 | -72,399,000 | -71,923,000 | -50,262,000 | -45,565,000 | -38,998,000 | -39,497,000 | -40,552,000 | -28,554,000 | -24,994,000 | -21,723,000 | -17,958,000 | -12,164,000 | -10,811,000 | -9,157,000 | -6,164,000 | -6,819,000 | -2,407,000 | -5,429,000 | -6,231,000 | -5,314,000 | -5,093,000 | -6,584,000 | -5,861,000 | 29,129,000 | -4,242,000 | -4,296,000 | -5,496,000 | -8,706,000 | -8,774,000 | -12,821,000 | -15,168,000 | -14,211,000 | -16,089,000 | -19,043,000 | -17,635,000 | -18,705,000 | -17,893,000 | -12,603,000 | -13,453,000 | -13,550,000 | -12,539,000 | -12,864,000 | -10,100,000 | -10,699,900 | -12,812,500 | -6,493,700 | -5,800,200 | -7,455,400 | -6,322,500 | -5,885,300 | 
  yoy  | 6.36% | 26.82% | 339.28% | -154.77% | 902.21% | -128.39% | -175.86% | 87.18% | -109.02% | -52.59% | 3.15% | 101.73% | -23.01% | 69.26% | -33.51% | -82.19% | -0.68% | -25.41% | 19.08% | 89.12% | -22.91% | 2.15% | -16.17% | -25.87% | -10.91% | 59.86% | -2.30% | -7.60% | -6.36% | -38.27% | -11.98% | -8.41% | -4.85% | 76.69% | 71.69% | 85.65% | 82.10% | 23.94% | 59.57% | 56.03% | 81.82% | 125.82% | 134.74% | 131.19% | 137.23% | 191.34% | 78.38% | 349.15% | 68.67% | -1.08% | 28.32% | -52.74% | -17.54% | 6.31% | -118.24% | 20.06% | 53.26% | 6.64% | -434.59% | -51.65% | -66.49% | -63.77% | -38.74% | -45.47% | -32.67% | -13.99% | -24.03% | -10.08% | 51.10% | 31.09% | 38.04% | 42.70% | -2.03% | 33.20% | 26.64% | -2.13% | 98.10% | 74.13% | 43.52% | 102.65% | 10.34% | ||||
  qoq  | 67.83% | -87.43% | 385.09% | 3.97% | 100.11% | -56.47% | -160.48% | -2002.40% | -105.67% | 16.33% | 49.24% | -8.28% | -70.22% | 153.08% | 191.86% | -64.99% | -34.54% | -0.58% | -21.81% | 95.18% | -50.84% | 58.72% | 24.17% | -20.44% | -34.85% | 30.26% | 9.80% | -4.38% | 16.89% | -20.39% | 3.84% | -3.10% | -22.94% | 13.52% | 8.06% | 0.66% | 43.10% | 10.31% | 16.84% | -1.26% | -2.60% | 42.02% | 14.24% | 15.06% | 20.97% | 47.63% | 12.52% | 18.06% | 48.56% | -9.61% | 183.30% | -55.66% | -12.87% | 17.26% | 4.34% | -22.65% | 12.34% | -120.12% | -786.68% | -1.26% | -21.83% | -36.87% | -0.78% | -31.57% | -15.47% | 6.73% | -11.67% | -15.51% | 7.98% | -5.72% | 4.54% | 41.97% | -6.32% | -0.72% | 8.06% | -2.53% | 27.37% | -5.61% | -16.49% | 97.31% | 11.96% | -22.20% | 17.92% | 7.43% | |
  operating margin %  | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  interest income  | 7,243,000 | 7,901,000 | 7,007,000 | 6,586,000 | 6,359,000 | 5,506,000 | 4,759,000 | 4,125,000 | 4,550,000 | 3,800,000 | 3,630,000 | 2,295,000 | 580,000 | 105,000 | 129,000 | 129,000 | 133,000 | 200,000 | 554,000 | 1,242,000 | 1,825,000 | 2,989,000 | 3,272,000 | 2,432,000 | 2,527,000 | 2,934,000 | 1,670,000 | 1,229,000 | 1,279,000 | 1,170,000 | 1,107,000 | 1,063,000 | 993,000 | 963,000 | 876,000 | 786,000 | 601,000 | 500,000 | 111,000 | 92,000 | 119,000 | 177,000 | 188,000 | 208,000 | 228,000 | 130,000 | 115,000 | 116,000 | 76,000 | 41,000 | 9,000 | 5,000 | 10,000 | 13,000 | 14,000 | 17,000 | 28,000 | 28,000 | 12,000 | 15,000 | 8,000 | 21,000 | 33,000 | 67,000 | 117,000 | 191,000 | 285,000 | 521,000 | 802,000 | 1,307,000 | 1,729,000 | 1,919,000 | 1,920,000 | 964,000 | 1,160,000 | 1,327,000 | 1,041,000 | 625,000 | 549,000 | 546,700 | 494,400 | 261,300 | 198,100 | 204,400 | 117,400 | 
  other income  | 594,000 | 588,000 | 575,000 | 576,000 | 386,000 | 286,000 | 1,508,000 | -1,244,000 | 4,845,000 | 1,543,000 | 2,156,000 | -497,000 | 340,000 | 1,623,000 | 383,000 | 178,000 | 145,000 | 265,000 | -202,000 | 437,000 | -1,497,000 | 491,000 | 747,000 | -12,000 | -229,000 | 127,000 | -1,720,000 | -247,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  income before income taxes  | 40,211,000 | 27,779,000 | 161,085,000 | 38,806,000 | 37,182,000 | 21,002,000 | 39,703,000 | -52,143,000 | 6,343,000 | -44,939,000 | -40,890,000 | -26,415,000 | -33,568,000 | -112,571,000 | -42,905,000 | -14,789,000 | -43,398,000 | -66,427,000 | -66,343,000 | -84,859,000 | -41,748,000 | -88,023,000 | -52,636,000 | -42,242,000 | -54,576,000 | -84,929,000 | -65,478,000 | -61,762,000 | -63,047,000 | -53,649,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
  income tax expense  | 13,545,000 | 8,792,000 | 17,343,000 | 6,041,000 | 3,793,000 | -6,094,000 | 13,033,000 | 443,000 | 485,000 | 189,000 | -332,000 | 473,000 | 21,000 | 417,000 | -199,000 | 393,000 | 365,000 | 375,000 | 14,000 | 376,000 | 219,000 | 647,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  net income  | 26,666,000 | 18,987,000 | 143,742,000 | 32,765,000 | 33,389,000 | 16,555,000 | 45,797,000 | -65,176,000 | 1,114,000 | -43,021,000 | -41,725,000 | -27,183,000 | -34,011,000 | -113,056,000 | -43,094,000 | -14,457,000 | -43,871,000 | -66,448,000 | -66,760,000 | -84,660,000 | -42,141,000 | -88,023,000 | -53,036,000 | -41,978,000 | -54,941,000 | -85,304,000 | -65,492,000 | -62,138,000 | -63,266,000 | -54,296,000 | -68,871,000 | -65,248,000 | -67,441,000 | -87,843,000 | -78,696,000 | -71,613,000 | -71,322,000 | -49,762,000 | -45,784,000 | -38,906,000 | -39,378,000 | -40,375,000 | -28,366,000 | -24,786,000 | -21,495,000 | -17,828,000 | -12,049,000 | -10,695,000 | -9,081,000 | -6,123,000 | -6,810,000 | -2,402,000 | -5,419,000 | -6,218,000 | -5,300,000 | -5,076,000 | -6,556,000 | -5,833,000 | 29,141,000 | -4,227,000 | -4,288,000 | -5,487,000 | -8,689,000 | -8,728,000 | -12,728,000 | -15,001,000 | -13,963,000 | -15,614,000 | -18,287,000 | -16,380,000 | -17,039,000 | -16,045,000 | -10,753,000 | -12,554,000 | -12,450,000 | -11,263,000 | -11,867,000 | -9,467,000 | -10,202,900 | -12,306,100 | -6,036,900 | -5,589,200 | -7,334,800 | -6,214,500 | -5,886,500 | 
  yoy  | -20.14% | 14.69% | 213.87% | -150.27% | 2897.22% | -138.48% | -209.76% | 139.77% | -103.28% | -61.95% | -3.18% | 88.03% | -22.47% | 70.14% | -35.45% | -82.92% | 4.11% | -24.51% | 25.88% | 101.68% | -23.30% | 3.19% | -19.02% | -32.44% | -13.16% | 57.11% | -4.91% | -4.77% | -6.19% | -38.19% | -12.48% | -8.89% | -5.44% | 76.53% | 71.89% | 84.07% | 81.12% | 23.25% | 61.40% | 56.97% | 83.20% | 126.47% | 135.42% | 131.75% | 136.70% | 191.16% | 76.93% | 345.25% | 67.58% | -1.53% | 28.49% | -52.68% | -17.34% | 6.60% | -118.19% | 20.09% | 52.89% | 6.31% | -435.38% | -51.57% | -66.31% | -63.42% | -37.77% | -44.10% | -30.40% | -8.42% | -18.05% | -2.69% | 70.06% | 30.48% | 36.86% | 42.46% | -9.39% | 32.61% | 22.02% | -8.48% | 96.57% | 69.38% | 39.10% | 98.02% | 2.55% | ||||
  qoq  | 40.44% | -86.79% | 338.71% | -1.87% | 101.69% | -63.85% | -170.27% | -5950.63% | -102.59% | 3.11% | 53.50% | -20.08% | -69.92% | 162.35% | 198.08% | -67.05% | -33.98% | -0.47% | -21.14% | 100.90% | -52.13% | 65.97% | 26.34% | -23.59% | -35.59% | 30.25% | 5.40% | -1.78% | 16.52% | -21.16% | 5.55% | -3.25% | -23.23% | 11.62% | 9.89% | 0.41% | 43.33% | 8.69% | 17.68% | -1.20% | -2.47% | 42.34% | 14.44% | 15.31% | 20.57% | 47.96% | 12.66% | 17.77% | 48.31% | -10.09% | 183.51% | -55.67% | -12.85% | 17.32% | 4.41% | -22.57% | 12.39% | -120.02% | -789.40% | -1.42% | -21.85% | -36.85% | -0.45% | -31.43% | -15.15% | 7.43% | -10.57% | -14.62% | 11.64% | -3.87% | 6.20% | 49.21% | -14.35% | 0.84% | 10.54% | -5.09% | 25.35% | -7.21% | -17.09% | 103.85% | 8.01% | -23.80% | 18.03% | 5.57% | |
  net income margin %  | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  earnings per share:  | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  basic  | 0.16 | 0.11 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  diluted  | 0.16 | 0.11 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  weighted-average common shares outstanding:  | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  basic  | 167,827 | 166,808 | 165,717 | 165,974 | 165,551 | 164,798 | 163,458 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  diluted  | 168,681 | 167,668 | 166,362 | 166,178 | 166,174 | 166,623 | 165,046 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  earnings (net income) per share:  | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  basic  | 0.87 | 0.2 | 0.2 | 0.1 | 0.01 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  diluted  | 0.86 | 0.2 | 0.2 | 0.1 | 0.01 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  income tax benefit  | 4,447,000 | 424,000 | 768,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  net income per common share, basic and diluted  | 280 | -400 | -270 | -260 | -170 | -210 | -700 | -270 | -90 | -270 | -420 | -420 | -540 | -270 | -570 | -340 | -290 | -380 | -590 | -500 | -500 | -510 | -440 | -550 | -530 | -550 | -720 | -650 | -610 | -630 | -450 | -450 | -390 | -390 | -400 | -290 | -250 | -220 | -190 | -130 | -120 | -110 | -80 | -65 | -40 | 0 | -120 | -85 | -100 | -120 | -120 | -92.5 | -110 | -110 | -140 | -220 | -230 | -340 | -400 | -370 | -420 | -490 | -440 | -460 | -430 | -290 | -420 | -1,608.8 | -0.38 | -0.43 | -0.39 | -0.44 | -0.53 | -0.26 | -0.31 | -0.45 | -0.37 | -0.42 | |||||||
  weighted-average common shares outstanding, basic and diluted  | 163,819,000 | 164,234,000 | 162,263,000 | 161,683,000 | 161,852,000 | 161,654,000 | 161,231,000 | 160,493,000 | 160,663,000 | 160,421,000 | 160,011,000 | 157,331,000 | 158,129,000 | 156,535,000 | 155,368,000 | 147,199,000 | 145,906,000 | 144,314,000 | 143,981,000 | 126,583,000 | 125,009,000 | 124,910,000 | 124,727,000 | 122,600,000 | 122,484,000 | 122,122,000 | 121,651,000 | 115,858,000 | 117,497,000 | 113,308,000 | 111,346,000 | 100,630,000 | 100,756,000 | 100,349,000 | 100,197,000 | 97,248,000 | 99,497,000 | 99,048,000 | 92,968,000 | 85,715,000 | 89,504,000 | 83,410,000 | 78,748,000 | 53,911,000 | 52,961,000 | 52,903,000 | 52,800,000 | 52,677,000 | 50,367,000 | 38,383,000 | 38,347,000 | 38,333,000 | 37,476,000 | 37,383,000 | 37,220,000 | 37,179,000 | 37,113,000 | 37,137,000 | 37,102,000 | 37,053,000 | 35,211,000 | 36,946,000 | 36,894,000 | 30,016,000 | 27,923,000 | 29,732,000 | 27,792,000 | 24,308,000 | 22,014,443 | 23,343,309 | 23,274,186 | 17,903,209 | 10,353,351 | 16,628,914 | 6,552,366 | ||||||||||
  income tax (benefit) expense  | 5,229,000 | -1,918,000 | 119,000 | -264,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  weighted-average shares outstanding:  | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  basic  | 167,827 | 166,808 | 165,717 | 165,974 | 165,551 | 164,798 | 163,458 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  diluted  | 168,681 | 167,668 | 166,362 | 166,178 | 166,174 | 166,623 | 165,046 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  license fees and royalties  | 117,000 | 2,994,000 | 2,680,000 | 2,507,000 | 2,793,000 | 2,796,000 | 2,575,000 | 2,175,000 | 2,314,000 | 2,273,000 | 2,037,000 | 1,630,000 | 1,569,000 | 1,536,000 | 1,516,000 | 1,332,000 | 1,248,000 | 1,078,000 | 982,000 | 675,000 | 608,000 | 475,000 | 248,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  collaborative revenue  | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  collaborative revenues  | 4,000 | 17,000 | 39,000 | 1,000 | 4,000 | 48,000 | 15,000 | 28,000 | 30,000 | 37,000 | 240,000 | 451,000 | 417,000 | 380,000 | 3,478,000 | 599,000 | 450,000 | 588,000 | 584,000 | 460,000 | 435,000 | 35,404,000 | 2,301,000 | 2,297,000 | 2,133,000 | 1,769,000 | 2,435,000 | 1,820,000 | 374,000 | 325,000 | 282,000 | 177,000 | 806,000 | 1,583,000 | 1,957,000 | 2,055,000 | 1,960,000 | 1,773,000 | 1,943,000 | 1,881,000 | 2,537,000 | 2,443,000 | 3,673,500 | 2,514,600 | 2,325,200 | ||||||||||||||||||||||||||||||||||||||||
  general and administrative  | 27,491,000 | 22,616,000 | 20,308,000 | 21,119,000 | 24,261,000 | 10,420,000 | 8,057,000 | 7,952,000 | 6,320,000 | 4,276,000 | 3,797,000 | 2,496,000 | 2,151,000 | 2,298,000 | 1,485,000 | 1,556,000 | 1,660,000 | 1,478,000 | 1,519,000 | 2,729,000 | 1,884,000 | 1,518,000 | 1,578,000 | 1,552,000 | 1,814,000 | 2,639,000 | 1,994,000 | 2,662,000 | 2,988,000 | 2,390,000 | 2,974,000 | 3,184,000 | 3,270,000 | 3,010,000 | 2,941,000 | 3,163,000 | 3,152,000 | 4,404,000 | 2,364,000 | 2,296,000 | 2,284,000 | 2,598,800 | 2,098,300 | 2,050,300 | 1,638,600 | 1,787,400 | 1,311,000 | 879,900 | |||||||||||||||||||||||||||||||||||||
  comprehensive loss  | -3,511,000 | -2,400,000 | -5,422,000 | -6,221,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  interest expense  | -12,000 | -16,000 | -21,000 | -24,000 | -24,000 | -37,000 | -46,000 | -46,000 | -52,000 | -63,000 | -71,000 | -70,000 | -65,000 | -60,000 | -51,000 | -44,000 | -43,000 | -52,000 | -40,300 | -37,600 | -50,300 | -77,500 | -96,400 | -118,600 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  benefit from income from (settlement of) litigation  | -3,981,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  income before change in accounting principle  | -17,039,000 | -16,045,000 | -10,753,000 | -12,554,000 | -12,450,000 | -11,263,000 | -11,867,000 | -9,518,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  cumulative effect of change in accounting principle  | 51,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  before change in accounting principle  | -460 | -430 | -290 | -420 | -1,608.8 | -0.38 | -0.43 | -0.39 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  benefit from income from litigation  | 194,000 | 227,000 | 360,000 | 5,861,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  net income per common share, basic and diluted:  | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  stock-based compensation  | 79,800 | 461,800 | 394,900 | 371,200 | 376,500 | 669,600 | 614,500 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  participation of preferred stock  | -3,109,900 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  net income available to common stockholders  | -10,202,900 | -12,306,100 | -6,036,900 | -5,589,200 | -7,334,800 | -6,214,500 | -2,776,600 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  net income available to participating preferred stockholders  | -3,109,900 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  net income per participating preferred share, basic and diluted  | -0.31 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  weighted-average participating preferred shares outstanding, basic and diluted  | 9,900,913 | 9,900,913 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  excludes stock-based compensation as follows:  | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  collaborative revenues—related party  | 1,083,400 | 1,506,300 | 1,015,700 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  other collaborative research revenues  | 75,000 | 
The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.
