7Baggers

Zymeworks Inc
(NASDAQ:ZYME) 

ZYME stock logo

Zymeworks Inc., a clinical-stage biopharmaceutical company, discovers, develops, and commercializes biotherapeutics for the treatment of cancer. The company's lead product candidates include zanidatamab, a novel bispecific antibody that is in Phase 1 and Phase 2 clinical trials for the treatment of ...

Founded: 2003
Full Time Employees: 325
Sector: Healthcare
Industry: Biotechnology

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At a glance:
Bull Thesis:
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Income Statements:
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 
                 
      revenue
                 
      yoy
                 
      qoq
                 
      research and development collaborations
    27,614,000 48,726,000 27,110,000 31,031,000 16,000,000 19,243,000 10,030,000 16,926,000 16,506,000 7,002,000 35,578,000 402,493,000 2,631,000 
      operating expenses:
                 
      research and development
    35,578,000 34,449,000 35,738,000 37,063,000 36,353,000 29,163,000 32,042,000 25,524,000 32,775,000 39,408,000 45,912,000 52,967,000 37,097,000 
      general and administrative
    14,146,000 14,951,000 16,985,000 16,185,000 13,852,000 15,679,000 15,790,000 14,823,000 16,968,000 21,708,000 16,947,000 30,131,000 15,892,000 
      impairment on acquired ipr&d
                 
      total operating expenses
    49,724,000 49,400,000 52,723,000 53,248,000 50,205,000 62,129,000 47,832,000 40,347,000 49,743,000 61,116,000 62,859,000 83,098,000 52,989,000 
      income from operations
    -22,110,000 -674,000 -25,613,000 -22,217,000 -34,205,000 -42,886,000 -37,802,000 -23,421,000 -33,237,000 -54,114,000 -27,281,000 319,395,000 -50,358,000 
      yoy
    -35.36% -98.43% -32.24% -5.14% 2.91% -20.75% 38.57% -107.33% -34.00%     
      qoq
    3180.42% -97.37% 15.29% -35.05% -20.24% 13.45% 61.40% -29.53% -38.58% 98.36% -108.54% -734.25%  
      operating margin %
    -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% 
      other income:
                 
      interest income
    3,529,000 3,426,000 3,424,000 4,082,000 4,785,000 5,154,000 5,920,000 5,049,000 5,026,000 4,825,000 4,805,000 1,733,000 1,125,000 
      other income
    315,000 -621,000 49,000 344,000 -204,000 114,000 304,000 -832,000 634,000 -209,000  -692,000 1,358,000 
      total other income
    3,844,000 2,805,000 3,473,000 4,426,000 4,581,000 5,268,000 6,224,000 4,217,000 5,660,000 4,616,000 4,318,000 1,041,000 2,483,000 
      income before income taxes
    -18,266,000 2,131,000 -22,140,000 -17,791,000 -29,624,000 -37,618,000 -31,578,000 -19,204,000 -27,577,000 -49,498,000 -22,963,000 320,436,000 -47,875,000 
      income tax expense
    -1,336,000  -496,000 -92,250 -226,000 -68,000 -75,000       
      net income
    -19,602,000 2,317,000 -22,636,000 -23,506,000 -29,850,000 -37,686,000 -31,653,000 -14,482,000 -28,687,000 -51,152,000 -24,353,000 -18,156,250  
      yoy
    -34.33% -106.15% -28.49% 62.31% 4.05% -26.33% 29.98% -20.24% NaN%     
      qoq
    -946.01% -110.24% -3.70% -21.25% -20.79% 19.06% 118.57% -49.52% -43.92% 110.04% 34.13% NaN%  
      net income margin %
    -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% 
      other comprehensive income:
                 
      unrealized income on available for sale securities, net of tax of nil
    290,000 66,000 546,000 -953,000 1,905,000  -1,121,000       
      total other comprehensive income
    290,000 66,000 546,000 -953,000 1,905,000  -1,121,000    720,000   
      comprehensive loss
    -19,312,000  -22,090,000 -24,646,250 -27,945,000 -37,866,000 -32,774,000 -26,457,750 -29,172,000 -53,026,000 -23,633,000   
      net income per common share
                 
      basic
    -260  -300 -320 -390         
      diluted
    -260  -300 -320 -390         
      weighted-average common stock outstanding
                 
      basic
    75,767,778,000 75,337,168,000 75,171,020,000 75,846,681,000 76,128,531,000 76,392,593,000 76,214,833,000 68,863,010,000 70,575,773,000 67,281,028,000 66,739,308,000 65,194,775,000 66,477,016,000 
      diluted
    75,775,214,000 77,378,449,000 75,226,387,000 75,878,738,000 76,157,101,000 76,396,217,000 76,248,158,000 68,863,010,000 70,575,773,000 67,284,511,000 66,742,080,000 65,249,184,000 66,478,157,000 
      income tax recovery
     186,000          -11,005,000 29,000 
      comprehensive income
     2,383,000            
      net earnings per common share
                 
      basic
     30            
      diluted
     30            
      impairment on acquired in-process research and development assets
       4,321,750  17,287,000        
      other comprehensive loss:
                 
      unrealized loss on available for sale securities, net of tax of nil
         -180,000  -409,750 -485,000 -1,874,000    
      total other comprehensive loss
         -180,000  -409,750 -485,000 -1,874,000    
      net loss per common share
                 
      basic
         -490 -420 -382.5 -410 -760 -360 -715 -720 
      diluted
         -490 -420 -382.5 -410 -760 -370 -715 -720 
      balance at january 1, 2024
         1,000 1,000       
      issuance of common stock on exercise of options
                 
      issuance of common stock through employee stock purchase plan
                 
      issuance of common stock upon vesting of restricted stock units
                 
      issuance of common stock for retracted exchangeable shares
           -191,911,250      
      stock-based compensation
                 
      other comprehensive loss
                 
      balance at march 31, 2024
         1,000 1,000       
      balance at june 30, 2024
         1,000        
      income tax (expense) recovery
           -1,038,500 -1,110,000 -1,654,000 -1,390,000   
      balance at january 1, 2023
           356,133,250 1,000 1,000 1,000   
      other comprehensive income
                 
      balance at march 31, 2023
           164,222,000 1,000 1,000 1,000   
      issuance of common stock upon vesting of rsus
                 
      issuance of common stock in connection with at-the-market
                 
      balance at june 30, 2023
           162,847,000 1,000 1,000    
      balance at september 30, 2023
           162,804,750 1,000     
      other expense
              -487,000   
      unrealized gain on available for sale securities, net of tax of nil
              720,000   
      net loss and comprehensive loss
               -46,272,500 -47,846,000 
      weighted-average common shares outstanding
                 
      basic
    75,767,778,000 75,337,168,000 75,171,020,000 75,846,681,000 76,128,531,000 76,392,593,000 76,214,833,000 68,863,010,000 70,575,773,000 67,281,028,000 66,739,308,000 65,194,775,000 66,477,016,000 
      diluted
    75,775,214,000 77,378,449,000 75,226,387,000 75,878,738,000 76,157,101,000 76,396,217,000 76,248,158,000 68,863,010,000 70,575,773,000 67,284,511,000 66,742,080,000 65,249,184,000 66,478,157,000 
      balance at january 1, 2022
               -170,776,000 46,633,935,000 
      issuance of common shares on exercise of options
                2,112,000 
      issuance of common shares through employee stock purchase plan
                61,801,000 
      issuance of common shares upon vesting of restricted stock units
                37,398,000 
      issuance of common shares and pre-funded warrants in connection with public offering, net of offering costs
                11,035,000,000 
      balance at march 31, 2022
               -188,932,250 57,770,246,000 
      issuance of common shares upon vesting of rsus
                958,000 
      stock-based compensation expense
                 
      balance at june 30, 2022
               -205,087,000 57,772,461,000 
      issuance of common shares upon exercise of pre-funded warrants
                3,787,675,000 
      balance at september 30, 2022
               -217,048,500 61,694,387,000 
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 
                     
        assets
                     
        current assets:
                     
        cash and cash equivalents
      244,282,000 41,157,000 64,834,000 98,253,000 76,204,000 66,103,000 122,356,000 70,963,000 114,814,000 157,557,000 94,332,000 142,100,000 181,583,000 400,912,000 96,082,000 
        short-term marketable securities
      120,445,000 187,640,000 187,099,000 183,126,000 189,083,000 159,673,000 174,844,000 259,183,000 230,233,000       
        accounts receivable
      4,674,000 4,638,000 29,352,000 2,631,000 24,594,000 55,815,000 23,704,000 32,081,000 30,949,000 19,477,000 67,273,000 48,819,000 66,916,000 33,400,000 6,728,000 
        prepaid expenses and other current assets
      16,279,000 15,332,000 10,427,000 12,120,000 16,586,000 18,860,000 22,865,000 21,268,000 17,824,000 19,122,000 11,955,000 31,428,000 18,665,000 19,074,000 17,686,000 
        total current assets
      385,680,000 248,767,000 291,712,000 296,130,000 306,467,000 300,451,000 343,769,000 383,495,000 393,820,000 412,926,000 374,634,000 420,336,000 426,372,000 544,706,000 190,656,000 
        long-term marketable securities
      39,116,000 41,787,000 47,427,000 51,996,000 56,324,000 98,428,000 77,667,000 65,794,000 75,446,000       
        long-term prepaids and other assets
      6,652,000 6,674,000 7,388,000 8,855,000 9,096,000 8,919,000 7,228,000 7,181,000 7,676,000       
        deferred tax asset
      4,707,000 4,707,000 4,862,000 4,769,000 4,849,000 4,385,000 4,206,000 3,945,000 3,704,000 3,615,000 1,315,000 1,359,000 1,405,000 1,345,000 3,028,000 
        property and equipment
      14,854,000 15,502,000 15,819,000 16,314,000 16,685,000 17,650,000 18,333,000 18,470,000 18,972,000 19,847,000 20,904,000 22,375,000 23,514,000 24,713,000 25,717,000 
        operating lease right-of-use assets
      14,016,000 15,724,000 16,648,000 16,260,000 16,723,000 16,666,000 17,355,000 17,279,000 17,067,000 17,696,000 17,857,000 20,796,000 22,300,000 22,937,000 23,564,000 
        intangible assets
      1,174,000 1,350,000 1,397,000 2,045,000 3,362,000 4,576,000 6,407,000 7,113,000 7,423,000 7,656,000 8,003,000 7,397,000 8,075,000 8,755,000 9,021,000 
        goodwill
      12,016,000 12,016,000 12,016,000 12,016,000 12,016,000 12,016,000 12,016,000 12,016,000 12,016,000 12,016,000 12,016,000 12,016,000 12,016,000 12,016,000 12,016,000 
        total assets
      478,215,000 346,527,000 397,269,000 408,385,000 425,522,000 463,091,000 487,152,000 515,634,000 553,752,000 580,880,000 556,366,000 602,054,000 600,743,000 648,725,000 300,263,000 
        liabilities and stockholders’ equity
                     
        current liabilities:
                     
        accounts payable and accrued liabilities
      30,226,000 36,346,000 34,430,000 31,003,000 38,223,000 59,838,000 51,707,000 44,420,000 47,434,000 45,032,000 67,789,000 69,919,000 59,250,000 87,468,000 52,271,000 
        income tax payable
      66,000 83,000 1,016,000 102,000 127,000 128,000 2,071,000 1,934,000 1,861,000 1,811,000 831,000 1,158,000 840,000 840,000  
        current portion of operating lease liability
      3,279,000 3,471,000 3,400,000 3,586,000 3,258,000 2,740,000 2,943,000 2,839,000 4,155,000 4,261,000 3,841,000 3,645,000 3,372,000 3,322,000 4,605,000 
        deferred revenue
      2,078,000 14,606,000 3,197,000 3,811,000 23,495,000 14,607,000 27,188,000 5,520,000 3,440,000 32,941,000 32,941,000 30,588,000 2,353,000 2,353,000 32,941,000 
        total current liabilities
      35,649,000 42,318,000 42,043,000 38,502,000 65,103,000 88,294,000 83,909,000 54,713,000 56,890,000 55,763,000 72,847,000 93,546,000 67,319,000 95,625,000 57,706,000 
        long-term portion of operating lease liability
      13,763,000 14,796,000 15,504,000 15,092,000 15,174,000 15,738,000 17,274,000 17,192,000 20,977,000 22,369,000 22,408,000 23,488,000 23,847,000 24,667,000 25,334,000 
        liability related to sale of future royalties
      246,503,000               
        other long-term liabilities
      278,000 278,000 278,000 828,000 856,000 923,000 929,000 1,229,000 1,594,000 1,701,000 1,858,000 3,597,000 3,595,000 3,101,000 2,934,000 
        deferred tax liability
      3,827,000 6,028,000 4,773,000 4,850,000 4,815,000 4,761,000 3,455,000 3,398,000 3,351,000 3,300,000 1,968,000 1,916,000 1,856,000 1,788,000 1,590,000 
        total liabilities
      314,626,000 78,026,000 77,205,000 73,879,000 100,555,000 124,323,000 120,174,000 109,473,000 115,753,000 116,074,000 132,022,000 153,135,000 127,205,000 155,769,000 120,505,000 
        stockholders’ equity:
                     
        common stock, 0.00001 par value...
      1,128,553,000  1,092,929,000 1,074,079,000 1,021,950,000  1,014,327,000 1,005,310,000 1,003,481,000  932,138,000 929,396,000 900,490,000   
        preferred shares, 0.00001 par value...
                     
        exchangeable shares, no par value, 550,884 and 553,184 issued and outstanding shares at march 31, 2026 and december 31, 2025, respectively
      7,905,000               
        additional paid-in capital
      107,530,000 114,626,000 111,489,000 109,243,000 154,216,000 152,249,000 148,296,000 147,343,000 143,144,000 142,274,000 154,114,000 152,257,000 152,677,000 151,614,000 169,262,000 
        accumulated other comprehensive loss
      -6,565,000 -6,079,000 -6,050,000 -6,340,000 -6,406,000 -6,952,000 -5,999,000 -7,904,000 -7,724,000 -6,603,000 -8,298,000 -7,813,000 -5,939,000 -6,659,000 -6,659,000 
        accumulated deficit
      -1,073,834,000 -953,160,000 -886,472,000 -850,654,000 -852,971,000 -830,335,000 -797,834,000 -746,776,000 -709,090,000 -677,437,000 -662,955,000 -634,268,000 -583,116,000 -558,763,000 -868,194,000 
        total stockholders’ equity
      163,589,000 268,501,000 320,064,000 334,506,000 324,967,000 338,768,000 366,978,000 406,161,000 437,999,000 464,806,000 424,344,000 448,919,000 473,538,000 492,956,000  
        total liabilities and stockholders’ equity
      478,215,000 346,527,000 397,269,000 408,385,000 425,522,000 463,091,000 487,152,000 515,634,000 553,752,000 580,880,000 556,366,000 602,054,000 600,743,000 648,725,000  
        deferred revenue and other consideration
       2,418,000    25,588,000    3,699,000 93,000 17,764,000    
        common shares, 0.00001 par value...
       1,105,176,000    1,015,618,000    997,227,000    886,322,000  
        exchangeable shares, no par value, 553,184 issued and outstanding shares at december 31, 2025 (december 31, 2024: 570,637) (note 10b).
       7,938,000              
        related party transactions
                     
        research collaboration and licensing agreements
                     
        commitments and contingencies
                     
        subsequent event
                     
        exchangeable shares, no par value, 569,189 and 570,637 issued and outstanding shares at september 30, 2025 and december 31, 2024, respectively
        8,168,000             
        exchangeable shares, no par value, 569,902 and 570,637 issued and outstanding shares at june 30, 2025 and december 31, 2024, respectively
         8,178,000            
        exchangeable shares, no par value, 569,902 and 570,637 issued and outstanding shares at march 31, 2025 and december 31, 2024, respectively
          8,178,000           
        acquired in-process research and development assets
                     
        exchangeable shares, no par value, 570,637 issued and outstanding shares at december 31, 2024 (december 31, 2023: 651,219) (note 10b).
           8,188,000          
        acquired in-process research and development
            171,000 341,000 17,628,000 17,628,000 17,628,000 17,628,000 17,628,000 17,628,000 17,628,000 
        exchangeable shares, no par value, 570,637 and 651,219 issued and outstanding shares at september 30, 2024 and december 31, 2023, respectively
            8,188,000         
        exchangeable shares, no par value, 570,637 and 651,219 issued and outstanding shares at june 30, 2024 and december 31, 2023, respectively
             8,188,000        
        exchangeable shares, no par value, 570,637 and 651,219 issued and outstanding shares at march 31, 2024 and december 31, 2023, respectively
              8,188,000       
        short-term investments
               216,770,000 201,074,000 197,989,000 159,208,000 91,320,000 70,160,000 
        deferred financing fees
               108,000 49,000  73,000 10,000 1,293,000 
        long-term investments
               82,148,000 95,674,000 92,235,000 72,474,000 886,000 886,000 
        long-term prepaid assets
               7,240,000 8,286,000 7,912,000 16,886,000 15,729,000 16,454,000 
        fair value of liability-classified stock options
               960,000    1,642,000  
        exchangeable shares, no par value, 651,219 issued and outstanding shares at december 31, 2023 (december 31, 2022: 1,424,533) (note 10b).
               9,345,000      
        fair value of liability classified stock options
                293,000 1,060,000 1,504,000  830,000 
        exchangeable shares, no par value, 651,219 and 1,424,533 issued and outstanding shares at september 30, 2023 and december 31, 2022, respectively
                9,345,000     
        subsequent events
                     
        exchangeable shares, no par value, 651,388 and 1,424,533 issued and outstanding shares at june 30, 2023 and december 31, 2022, respectively
                 9,347,000    
        exchangeable shares, no par value, 656,888 and 1,424,533 issued and outstanding shares at march 31, 2023 and december 31, 2022, respectively
                  9,426,000   
        exchangeable shares, no par value, 1,424,533 issued and outstanding shares at december 31, 2022 (december 31, 2021: nil) (note 10b).
                   20,442,000  
        liabilities and shareholders’ equity
                     
        other current liabilities
                     
        shareholders’ equity:
                     
        common shares, no par value; unlimited authorized shares at september 30, 2022 and december 31, 2021, respectively; 61,694,387 and 46,633,935 shares issued and outstanding at september 30, 2022 and december 31, 2021, respectively
                    885,349,000 
        total shareholders’ equity
                    179,758,000 
        total liabilities and shareholders’ equity
                    300,263,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 
                     
          cash flows from operating activities:
                     
          net loss
        -41,209,000 -19,602,000 2,317,000 -22,636,000  -29,850,000 -37,686,000 -31,653,000  -28,687,000 -51,152,000 -24,353,000  
          items not involving cash:
                     
          depreciation of property and equipment
        898,000 905,000 885,000 981,000 997,000 1,035,000 1,095,000 1,061,000 1,536,000 2,401,000 1,941,000 1,584,000 1,152,000 
          amortization of intangible assets
        185,000 648,000 1,606,000 1,617,000 2,002,000 980,000 812,000 702,000 673,000 672,000 678,000 679,000 529,000 
          stock-based compensation
                     
          amortization and impairment of operating lease right-of-use assets
                     
          impairment of acquired ipr&d
                   
          deferred income tax expense
                 95,000 106,000 9,000 1,881,000 
          change in fair value of contingent consideration liability
            -1,178,000 -700,000 299,000 -168,000 499,000 
          change in fair value of investments in equity instruments
                     
          unrealized foreign exchange loss
        305,000 -451,000         437,000 -298,000  
          changes in non-cash operating working capital:
                     
          accounts receivable
        24,713,000 -26,721,000 21,989,000 31,219,000 -31,630,000 7,880,000 -1,141,000 -11,468,000 47,795,000 -18,456,000 18,099,000 -33,516,000 -26,672,000 
          prepaid expenses and other current assets
        -5,120,000 3,267,000 5,490,000 2,872,000 1,670,000 -443,000 -3,489,000 -227,000 -7,681,000 17,979,000 -4,332,000 -1,671,000 -642,000 
          accounts payable and accrued liabilities
        1,335,000 3,341,000 -7,105,000 -21,219,000 7,338,000 6,539,000 -1,826,000 2,284,000 -22,300,000 -4,893,000 10,691,000 -28,266,000 37,567,000 
          operating lease liabilities
        -838,000 -872,000 -818,000 -814,000 -782,000 -732,000 -5,764,000 -1,035,000 -1,033,000 -949,000 -861,000 -820,000 -2,150,000 
          deferred revenue and other consideration
           -2,093,000 -1,599,000 3,333,000 2,080,000 -259,000 3,606,000 -15,318,000    
          income taxes payable
        -933,000 915,000 -26,000 -1,000 -1,943,000 137,000 74,000 50,000 979,000 -327,000    
          net cash from operating activities
          12,073,000 -3,407,000 -41,508,000 -5,877,000 -24,990,000 -37,669,000 13,954,000 -42,667,000 -6,399,000 -83,191,000 327,360,000 
          capital expenditures
          -514,000 65,000 -314,000 -899,000 -593,000 -185,000 -1,307,000 -930,000 -802,000  -348,000 
          free cash flows
          11,559,000 -3,342,000 -41,822,000 -6,776,000 -25,583,000 -37,854,000 12,647,000 -43,597,000 -7,201,000  327,012,000 
          cash flows from financing activities:
                     
          proceeds from issuance of common stock under at-the-market program and from public offerings, net of issuance costs
                   
          private placement
                     
          issuance of common stock on exercise of stock options
        6,825,000 7,923,000 1,384,000 772,000 785,000 5,196,000 1,133,000 1,743,000 770,000 1,329,000 1,391,000 1,516,000  
          issuance of common stock through employee stock purchase plan
        881,000 544,000 544,000 386,000 584,000 236,000  
          purchases of common stock for retirement
        -25,479,000    -9,427,000         
          deferred financing fees
            -92,000   -14,000 -12,000   -516,000 
          net cash from financing activities
        -18,742,000 -2,452,000 1,319,000 1,316,000 -8,644,000 -14,979,000 1,048,000 2,123,000 50,611,000 1,896,000 27,602,000 1,738,000 -377,000 
          cash flows from investing activities:
                     
          purchases of marketable securities
        -56,828,000 -35,054,000 -70,147,000 -34,032,000 -53,820,000 -52,687,000 -110,727,000 -66,509,000 -61,909,000 -125,085,000    
          proceeds from marketable securities
        62,916,000 35,832,000 79,776,000 46,552,000 47,920,000 125,946,000 91,852,000 59,847,000 62,326,000 119,200,000    
          acquisition of property and equipment
        -581,000 -410,000 -514,000 -16,000 -314,000 -899,000 -593,000 -185,000 -356,000 -930,000 -802,000 -386,000 -348,000 
          acquisition of intangible assets
        -139,000 -370,000 -322,000 -103,000 -503,000 -469,000 -1,398,000    -535,000 
          net cash from investing activities
        5,368,000 368,000 8,745,000 12,182,000 -6,214,000 72,257,000 -19,971,000 -7,316,000 -1,337,000 -7,020,000 -60,674,000 -138,222,000 -22,065,000 
          effect of exchange rate changes on cash and cash equivalents
        -44,000 77,000 -88,000 10,000 113,000 -8,000 62,000 119,000 -3,000 23,000 -12,000 346,000 -88,000 
          net change in cash and cash equivalents
        -23,677,000 -33,419,000 22,049,000 10,101,000 -56,253,000 51,393,000 -43,851,000 -42,743,000 63,225,000 -47,768,000 -39,483,000 -219,329,000 304,830,000 
          cash and cash equivalents, beginning of year
                     
          cash and cash equivalents, end of year
                     
          supplemental cash flow information:
                     
          net cash paid during the year for income taxes
                     
          supplemental disclosure of non-cash investing and finance items:
                     
          leased assets obtained in exchange for operating lease liabilities
        1,419,000 259,000 765,000    978,000 528,000   
          issuance of common stock upon exercise of pre-funded warrants
                   
          purchases of common stock not settled
        -40,000             
          acquisition of property and equipment and intangible assets in accounts payable and accrued liabilities
           81,000     -951,000     
          stock-based compensation expense
         6,911,000 5,871,000 6,402,000  4,664,000 4,555,000 3,552,000  2,040,000 367,000 2,325,000  
          amortization of operating lease right-of-use assets
         1,031,000 723,000 707,000  648,000 622,000 549,000  3,467,000 1,898,000 637,000  
          deferred income tax recovery
         -170,000 115,000 -410,000          
          deferred revenue
         -614,000            
          net cash provided used in operating activities
                     
          private placement for issuance of common stock
                     
          deferred financing costs
         -28,000            
          cash and cash equivalents, beginning of period
         66,103,000  157,557,000  400,912,000  
          cash and cash equivalents, end of period
         -33,419,000 22,049,000 76,204,000  51,393,000 -43,851,000 114,814,000  -47,768,000 -39,483,000 181,583,000  
          net cash paid during the period for income taxes
         660,000 196,000 387,000          
          supplemental disclosure of non-cash investing and financing items:
                     
          unrealized foreign exchange gain
           -32,000 -893,000   -487,000 353,000    299,000 
          net income
                     
          finance lease payments
            -2,000 -3,000 -3,000 -6,000 -7,000 -5,000 5,000 -14,000 
          deferred income tax (recovery) expense
             -204,000 -194,000 -38,000      
          deferred income tax
                     
          acquisition of property and equipment in accounts payable and accrued liabilities
                     
          proceeds from public offering, net of issuance costs
                     
          net (purchases)/redemptions of investments
                   -137,836,000  
          non-cash consideration from licensing agreement
                     
          proceeds from public offerings, net of issuance costs
                     
          net redemptions (purchases) of short-term investments
                     
          purchases of long-term investments
                     
          stock-based compensation (recovery) expense
                     
          issuance of common shares on exercise of stock options
                     
          issuance of common shares through employee stock purchase plan
                     
          net (purchases)/redemptions of short-term investments