7Baggers

Xenon Pharmaceuticals Inc
(NASDAQ:XENE) 

XENE stock logo

Xenon Pharmaceuticals Inc., a clinical-stage biopharmaceutical company, engages in developing therapeutics to treat patients with neurological disorders in Canada. Its clinical development pipeline includes XEN496, A Kv7 potassium channel modulator that is Phase III clinical trials for the treatment...

Founded: 1996
Full Time Employees: 100
Sector: Healthcare
Industry: Biotechnology
PharmaceuticalsHealthcare
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Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 
                                                   
      collaboration revenue
    		    7,500,000                             15,000 264,000 15,000 15,000  412,000 412,000 569,000 3,226,000 4,293,000 4,044,000 4,010,000 4,877,000 13,192,000 
      operating expenses:
    		                                               
      research and development
    		88,508,000 87,699,000 77,054,000 74,985,000 61,200,000 59,472,000 56,970,000 49,702,000 44,250,000 41,076,000 42,880,000 44,040,000 39,516,000 34,830,000 29,431,000 22,146,000 19,360,000 21,887,000 18,891,000 18,377,000 16,308,000 14,967,000 13,045,000 10,720,000 11,791,000 11,752,000 9,751,000 8,205,000 9,137,000 6,406,000 6,240,000 5,408,000 5,580,000 6,397,000 7,164,000 6,109,000 5,903,000  5,965,000 5,103,000 4,364,000 4,263,000 3,793,000 3,669,000 3,427,000 3,453,000 3,216,000 
      general and administrative
    		23,820,000 22,068,000 19,282,000 19,244,000 19,038,000 18,005,000 16,706,000 19,402,000 14,791,000 12,619,000 12,804,000 11,584,000 9,535,000 8,501,000 8,829,000 8,705,000 6,775,000 6,688,000 4,831,000 6,339,000 4,109,000 3,106,000 3,208,000 3,310,000 3,320,000 3,175,000 2,700,000 2,307,000 2,621,000 2,028,000 1,938,000 2,178,000 2,238,000 1,670,000 1,744,000 1,799,000 2,100,000  1,779,000 1,676,000 1,895,000 1,567,000 1,321,000 2,058,000 1,789,000 1,390,000 1,316,000 
      total operating expenses
    		112,328,000 109,767,000 96,336,000 94,229,000                                          3,105,250 4,532,000 
      income from operations
    		-112,328,000 -109,767,000 -96,336,000 -94,229,000 -72,738,000 -77,477,000 -73,676,000 -69,104,000 -59,041,000 -53,695,000 -55,684,000 -55,624,000 -49,051,000 -43,331,000 -38,128,000 -30,315,000 -17,369,000 -24,838,000 -15,598,000 -22,498,000 -16,059,000 -12,923,000 -9,699,000 -646,000 -8,033,000 -11,598,000 -8,951,000 -10,512,000 -11,758,000 -8,434,000 -14,178,000 -7,586,000 -7,818,000 -8,051,000 -8,644,000 -7,893,000 -7,987,000  -7,331,000 -6,366,000 -5,658,000 -2,603,000 -820,000 199,000 -1,206,000 35,000 8,661,000 
      yoy
    		54.43% 41.68% 30.76% 36.36% 23.20% 44.29% 32.31% 24.23% 20.37% 23.92% 46.04% 83.49% 182.41% 74.45% 144.44% 34.75% 8.16% 92.20% 60.82% 3382.66% 99.91% 11.42% 8.36% -93.85% -31.68% 37.51% -36.87% 38.57% 50.40% 4.76% 64.02% -3.89% -2.12%  17.91% 23.99% 41.16%  794.02% -3298.99% 369.15% -7537.14% -109.47%     
      qoq
    		2.33% 13.94% 2.24% 29.55% -6.12% 5.16% 6.62% 17.04% 9.96% -3.57% 0.11% 13.40% 13.20% 13.65% 25.77% 74.54% -30.07% 59.24% -30.67% 40.10% 24.27% 33.24% 1401.39% -91.96% -30.74% 29.57% -14.85% -10.60% 39.41% -40.51% 86.90% -2.97% -2.89% -6.86% 9.51% -1.18%   15.16% 12.51% 117.36% 217.44% -512.06% -116.50% -3545.71% -99.60%  
      operating margin %
    		-Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% -Infinity% -28884.85% -5655.78% -198.14% -664.65% -192.00% -1014.34% -368.49% -250.93% -147.99% -4.83% -113.49% -348.39% -255.74% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% Infinity% Infinity% 
      other income:
    		                                               
      interest income
    		6,907,000 5,340,000 6,206,000 7,199,000 8,083,000 9,422,000 10,329,000 10,837,000 11,355,000 8,691,000 6,982,000 6,524,000 5,423,000 4,463,000 3,066,000 816,000 368,000 263,000 76,000 55,000 72,000 89,000 166,000 912,000 1,116,000 437,000 528,000 706,000 682,000 658,000 325,000 125,000 108,000 95,000 124,000 109,000 149,000  114,000 123,000 99,000 97,000 130,000 163,000 152,000 152,000 138,000 
      foreign exchange gain
    		548,000 -296,000 -89,000 1,698,000 35,000 -1,478,000 237,000 10,000 167,000 -90,000 -407,000 383,000 313,000 602,000 -2,381,000 -411,000 299,000 214,000 -128,000 117,000 155,000 497,000 475,000 662,000 -238,000 97,000 -80,000 135,000 130,000 -425,000 148,000 -140,000 -284,000 -109,000 778,000 404,000 321,000  -497,000 227,000 2,296,000 -1,431,000 -3,137,000 806,000 -3,171,000 1,037,000 392,000 
      total other income
    		7,455,000 5,044,000 6,117,000 8,897,000                                            
      income before income taxes
    		-104,873,000 -104,723,000 -90,219,000 -85,332,000 -64,620,000 -69,533,000 -63,110,000 -58,257,000 -47,519,000 -44,948,000 -48,619,000 -47,681,000 -41,437,000 -36,256,000 -37,737,000 -31,198,000 -20,064,000 -25,080,000 -15,650,000 -22,326,000 -15,832,000 -12,337,000 -9,058,000 -214,000 -7,485,000 -11,412,000 -8,866,000 -10,036,000 -11,304,000                   
      income tax recovery
    		2,571,000 -538,000 -677,000 626,000  3,848,000 320,000 333,000  205,000 157,000 220,000  255,250 587,000 40,000 394,000 -484,000 205,000 217,000 68,000                           
      net income
    		-102,302,000 -105,261,000 -90,896,000 -84,706,000 -65,047,000 -65,685,000 -62,790,000 -57,924,000 -47,931,000 -44,743,000 -48,462,000 -47,461,000 -41,727,000 -37,395,000 -37,150,000                           -3,937,000 -3,827,000 1,168,000 -4,225,000 1,224,000 9,191,000 
      yoy
    		57.27% 60.25% 44.76% 46.24% 35.71% 46.81% 29.57% 22.05% 14.87% 19.65% 30.45%                               -421.65% -141.64%     
      qoq
    		-2.81% 15.80% 7.31% 30.22% -0.97% 4.61% 8.40% 20.85% 7.13% -7.67% 2.11% 13.74% 11.58% 0.66%                            2.87% -427.65% -127.64% -445.18% -86.68%  
      net income margin %
    		-Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% -Infinity% -28143.94% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% NaN% -Infinity% -Infinity% Infinity% -Infinity% Infinity% Infinity% 
      other comprehensive income:
    		                                               
      unrealized gain on available-for-sale securities
    		-1,546,000 -142,000 364,000 949,000 776,000 -2,948,000 3,548,000  -1,692,000 2,876,000 346,000  1,180,000                                   
      comprehensive loss
    		-103,848,000 -105,403,000 -90,532,000 -83,757,000 -64,271,000 -68,633,000 -59,242,000 -58,367,000 -49,623,000 -41,867,000 -48,116,000 -48,940,000 -40,547,000 -37,440,000 -39,115,000                                 
      net loss per common share
    		                                               
      basic and diluted
    		-1,170 -1,310 -1,150 -1,070 -830 -840 -810 -750 -620 -640 -730 -720 -630 -570 -570 -550 -350 -480 -360 -510 -420 -340 -250  -220 -410 -330 -370           -510  -230    -300   
      weighted-average common shares outstanding
    		                                               
      basic and diluted
    		87,345,717,000 79,253,751,000 79,247,976,000 78,953,445,000 78,687,503,000 77,894,643,000 77,926,205,000 77,671,128,000 77,594,599,000 66,889,005,000 66,002,163,000 65,861,138,000 65,724,681,000 60,542,142,000 65,465,069,000 56,192,922,000 54,852,792,000 43,627,452,000 41,193,267,000 43,106,207,000 36,824,619,000 34,542,213,000 34,994,944,000  33,189,733,000 25,939,405,000 25,793,482,000            15,268,964,000  14,394,000,000    14,212,579,000   
      operating expenses: - sum
    		    80,238,000 77,477,000 73,676,000 69,104,000 59,041,000 53,695,000 55,684,000 55,624,000 49,051,000 43,331,000 38,260,000 30,851,000 26,135,000 28,575,000 23,722,000 24,716,000 20,417,000 18,073,000 16,253,000 14,030,000 15,111,000 14,927,000 12,451,000 10,512,000 11,758,000 8,434,000 14,178,000 7,586,000 7,818,000 8,067,000 8,908,000 7,908,000 8,003,000  7,744,000 6,779,000 6,259,000       
      other income: - sum
    		    8,118,000 7,944,000 10,566,000 10,847,000 11,522,000 8,747,000 7,065,000 7,943,000 7,614,000 7,075,000 391,000                                 
      income tax expense
    		    -427,000    -412,000                    -37,000                   
      unrealized fair value gain on trading securities
    		         146,000 490,000 1,036,000 1,878,000 2,010,000 -294,000                                 
      other comprehensive loss:
    		                                               
      unrealized loss on available-for-sale securities
    		       -443,000    -1,479,000                                    
      revenue
    		              132,000 536,000 8,766,000 3,737,000 8,124,000 2,218,000 4,358,000 5,150,000 6,554,000 13,384,000 7,078,000 3,329,000 3,500,000                     
      yoy
    		          NaN% NaN% NaN%  -98.38% -75.83% 101.15% -27.44% 23.95% -83.43% -38.43% 54.70% 87.26%                         
      qoq
    		          NaN% NaN%   -75.37% -93.89% 134.57% -54.00% 266.28% -49.11% -15.38% -21.42% -51.03% 89.09% 112.62% -4.89%                      
      net loss attributable to preferred shareholders
    		             -17,000   -299,000 -487,000 -362,000 -521,000 -423,000 -350,000 -250,000 -5,000 -222,000 -422,000 -336,000 -380,000 -430,000 -375,000 -1,621,000 -1,303,000 -33,000               
      net loss attributable to common shareholders
    		         -44,743,000 -48,462,000 -47,461,000 -41,727,000 -37,378,000 -37,150,000 -31,158,000 -19,371,000 -25,077,000 -15,083,000 -21,588,000 -15,341,000 -11,973,000 -8,605,000 -170,000 -7,262,000 -10,954,000 -8,535,000 -9,627,000 -10,911,000 -8,183,000 -12,762,000 -6,498,000 -3,722,000            -4,225,000   
      income tax (expense) recovery
    		            -290,000                                   
      unrealized losses on available-for-sale securities
    		             -491,250 -1,965,000                                 
      unrealized fair value loss on marketable securities
    		               -1,288,000 -3,362,000                               
      net loss and comprehensive loss
    		               -31,158,000 -19,670,000 -25,564,000 -15,445,000 -22,109,000 -15,764,000 -12,323,000 -8,855,000 -175,000 -7,484,000 -11,376,000 -8,871,000 -10,007,000 -11,341,000 -8,558,000 -14,383,000 -7,801,000 -3,755,000 -8,065,000 -7,742,000 -7,380,000 -7,517,000  -7,714,000  -3,263,000       
      interest expense
    		                       -154,000 -330,000 -348,000 -363,000 -365,000 -358,000 -357,000 -678,000 -200,000 -159,000               
      loss on repayment of term loan
    		                       -988,000                        
      income tax
    		                     60,750 203,000 39,000 1,000 -3,250 -5,000 29,000                    
      weighted-average common shares outstanding
    		                                               
      basic
    		                       34,979,282,000    25,773,879,000 25,753,836,000 19,425,711,000 20,306,298,000 14,306,491,000 17,804,421,000 17,985,061,000 17,998,420,000 17,997,194,000 17,946,209,000 15,493,474,000  14,408,108,000  14,281,837,000 14,298,612,000 14,241,827,000  3,165,572,000 1,348,417 
      diluted
    		                       34,979,282,000    25,775,559,000 25,753,836,000 19,425,711,000 20,306,298,000 14,306,491,000 17,804,421,000 18,001,759,000 18,009,979,000 18,015,748,000 17,974,469,000   14,434,602,000    15,129,978,000    
      buy-out of future milestones and royalties
    		                              6,000,000                 
      gain on termination of collaboration agreement
    		                                4,398,000               
      net loss per common share
    		                                               
      basic
    		                            -420 -290 -630 -450 -210 -450 -430 -410 -420           
      diluted
    		                            -420 -290 -630 -450 -210 -450 -430 -410 -430           
      revenue:
    		                                               
      royalties
    		                                 1,000   1,000  1,000 1,000 32,000 1,000 1,000 2,000  1,000 1,000 
      revenue: - sum
    		                                 16,000 264,000 15,000 16,000  413,000 413,000 601,000       
      net income and comprehensive income
    		                                       -6,016,000        
      net income per common share
    		                                               
      basic
    		                                       -420  -270 -270 80  4,107.33 2.67 
      diluted
    		                                       -420  -270 -270 -70  3,278.29 1.69 
      weighted-average shares outstanding
    		                                               
      basic and diluted
    		87,345,717,000 79,253,751,000 79,247,976,000 78,953,445,000 78,687,503,000 77,894,643,000 77,926,205,000 77,671,128,000 77,594,599,000 66,889,005,000 66,002,163,000 65,861,138,000 65,724,681,000 60,542,142,000 65,465,069,000 56,192,922,000 54,852,792,000 43,627,452,000 41,193,267,000 43,106,207,000 36,824,619,000 34,542,213,000 34,994,944,000  33,189,733,000 25,939,405,000 25,793,482,000            15,268,964,000  14,394,000,000    14,212,579,000   
      net income attributable to participating securities
    		                                             2,049,750 5,596,000 
      net income attributable to common shareholders
    		                                         -3,937,000 -3,827,000 1,168,000  9,423,000 3,595,000 
      weighted-average shares outstanding
    		                                               
      basic
    		                       34,979,282,000    25,773,879,000 25,753,836,000 19,425,711,000 20,306,298,000 14,306,491,000 17,804,421,000 17,985,061,000 17,998,420,000 17,997,194,000 17,946,209,000 15,493,474,000  14,408,108,000  14,281,837,000 14,298,612,000 14,241,827,000  3,165,572,000 1,348,417 
      effects of dilutive securities
    		                                               
      stock options
    		                                             797,475,033 763,949 
      subscription rights
    		                                             2,861.75 10,400 
      diluted
    		                                         30,831,000 14,298,612,000   3,961,688,597 2,122,766 
      foreign currency translation adjustment
    		                                               
      comprehensive income
    		                                         -3,937,000 -3,827,000 1,168,000 -4,225,000   
      general and administrative - stock based compensation
    		                                           -1,880,000    
      weighted-average shares outstanding
    		                                               
      basic
    		                       34,979,282,000    25,773,879,000 25,753,836,000 19,425,711,000 20,306,298,000 14,306,491,000 17,804,421,000 17,985,061,000 17,998,420,000 17,997,194,000 17,946,209,000 15,493,474,000  14,408,108,000  14,281,837,000 14,298,612,000 14,241,827,000  3,165,572,000 1,348,417 
      diluted
    		                       34,979,282,000    25,775,559,000 25,753,836,000 19,425,711,000 20,306,298,000 14,306,491,000 17,804,421,000 18,001,759,000 18,009,979,000 18,015,748,000 17,974,469,000   14,434,602,000    15,129,978,000    
      net loss per common share:
    		                                               
      basic and diluted
    		-1,170 -1,310 -1,150 -1,070 -830 -840 -810 -750 -620 -640 -730 -720 -630 -570 -570 -550 -350 -480 -360 -510 -420 -340 -250  -220 -410 -330 -370           -510  -230    -300   
      weighted-average shares outstanding:
    		                                               
      basic and diluted
    		87,345,717,000 79,253,751,000 79,247,976,000 78,953,445,000 78,687,503,000 77,894,643,000 77,926,205,000 77,671,128,000 77,594,599,000 66,889,005,000 66,002,163,000 65,861,138,000 65,724,681,000 60,542,142,000 65,465,069,000 56,192,922,000 54,852,792,000 43,627,452,000 41,193,267,000 43,106,207,000 36,824,619,000 34,542,213,000 34,994,944,000  33,189,733,000 25,939,405,000 25,793,482,000            15,268,964,000  14,394,000,000    14,212,579,000   
      gain on write-off and disposal of assets
    		                                               
      net income per share
    		                                               
      basic
    		                                       -420  -270 -270 80  4,107.33 2.67 
      diluted
    		                                       -420  -270 -270 -70  3,278.29 1.69 
      weighted-average shares outstanding:
    		                                               
      basic
    		                       34,979,282,000    25,773,879,000 25,753,836,000 19,425,711,000 20,306,298,000 14,306,491,000 17,804,421,000 17,985,061,000 17,998,420,000 17,997,194,000 17,946,209,000 15,493,474,000  14,408,108,000  14,281,837,000 14,298,612,000 14,241,827,000  3,165,572,000 1,348,417 
      effects of dilutive securities:
    		                                               
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 
                                                     
        assets
      		                                               
        current assets:
      		                                               
        cash and cash equivalents
      		545,867,000 199,163,000 104,514,000 135,381,000 116,657,000 142,712,000 87,621,000 136,734,000 58,896,000 148,643,000 99,574,000 64,552,000 69,512,000 57,242,000 103,489,000 369,987,000 116,541,000 175,688,000 87,809,000 82,930,000 87,985,000 45,009,000 15,100,000 44,199,000 60,508,000 24,755,000 37,671,000 37,075,000 52,180,000 67,754,000 87,962,000 47,435,000 17,200,000 20,486,000 14,688,000 23,090,000 20,160,000 17,095,000 54,135,000 35,210,000 56,064,000 58,651,000 65,469,000 64,346,000 65,917,000 72,026,000 33,731,000 
        marketable securities
      		548,880,000 349,723,000 357,754,000 352,164,000 432,972,000 484,193,000 566,394,000 584,801,000 640,706,000 489,439,000 427,100,000 475,048,000 457,531,000 534,845,000 534,696,000 418,251,000 421,399,000 376,086,000 161,816,000 177,593,000 186,718,000 131,988,000 175,827,000 158,555,000 169,163,000 116,603,000 56,932,000 64,726,000 58,249,000 51,552,000 39,166,000 15,835,000 17,878,000 23,181,000 29,084,000 28,606,000 37,867,000 47,051,000 15,356,000 15,528,000    9,354,000 9,464,000 12,015,000 14,205,000 
        other receivables
      		1,165,000 1,371,000 812,000 1,097,000                                            
        prepaid expenses and other current assets
      		10,720,000 10,392,000 17,057,000 11,610,000 7,259,000 6,890,000 4,686,000 5,701,000 6,769,000 6,006,000 3,529,000 2,893,000 4,086,000 7,225,000 8,509,000 4,041,000 4,753,000 4,481,000 3,454,000 3,313,000 3,497,000 2,964,000 2,274,000 2,470,000 2,582,000 2,695,000 1,666,000 1,353,000 1,486,000 1,875,000 2,185,000 909,000 1,151,000 716,000 1,086,000 739,000 925,000 1,329,000 1,264,000 1,996,000 1,818,000 1,900,000 371,000 465,000 464,000 686,000 171,000 
        total current assets
      		1,106,632,000 560,649,000 480,137,000 500,252,000                                           48,269,000 
        marketable securities, long-term
      		244,874,000 37,152,000 92,988,000 137,297,000 141,498,000 127,496,000 149,317,000 129,062,000 185,836,000 292,792,000 112,407,000 112,592,000 160,265,000 128,682,000 113,989,000                                 
        operating lease right-of-use asset
      		6,288,000 6,626,000 6,960,000 7,290,000 7,617,000 7,939,000 8,258,000 8,573,000 8,884,000 9,193,000 9,497,000 9,799,000 10,097,000 10,406,000 7,559,000 7,730,000 7,900,000 8,056,000 2,967,000 3,086,000 3,206,000 3,326,000 886,000 1,029,000 832,000 933,000 1,036,000 1,135,000 1,233,000                   
        property, plant and equipment
      		8,294,000 8,721,000 8,887,000 9,205,000 9,696,000 10,278,000 10,162,000 10,138,000 9,393,000 9,653,000 10,236,000 9,563,000 7,975,000 6,500,000 4,575,000 4,536,000 4,336,000 4,466,000 4,261,000 4,326,000 3,691,000 3,554,000 2,954,000 2,347,000 2,155,000 1,660,000 1,212,000 1,316,000 1,198,000 991,000 962,000 1,086,000 1,101,000 1,070,000 1,154,000 1,308,000 1,376,000 1,404,000 1,542,000 1,663,000 1,790,000 1,989,000 2,130,000 2,174,000 2,353,000 2,476,000 1,999,000 
        deferred tax assets
      		12,417,000 12,864,000 11,750,000 11,049,000 10,879,000 9,666,000 1,054,000 733,000 400,000 802,000 601,000 445,000 221,000 509,000 514,000 311,000 207,000 465,000 811,000 544,000 514,000 523,000 478,000 290,000 186,000 238,000 178,000 116,000 72,000                   
        prepaid expenses, long-term
      		8,305,000 7,151,000 7,114,000 9,188,000 8,053,000 7,496,000 7,471,000 7,416,000 7,306,000 7,396,000 7,344,000 7,884,000 7,959,000 7,751,000                    230,000              
        total assets
      		1,386,810,000 633,163,000 607,836,000 674,281,000 743,280,000 798,139,000 835,901,000 884,011,000 919,023,000 964,798,000 671,093,000 684,899,000 719,868,000 754,146,000 775,813,000 807,380,000 558,059,000 572,007,000 264,353,000 274,711,000 290,671,000 189,186,000 199,128,000 210,676,000 237,043,000 147,697,000 98,904,000 105,892,000 114,550,000 122,428,000 130,455,000 65,436,000 37,762,000 46,121,000 46,359,000 54,226,000 60,786,000 67,487,000 73,371,000 55,687,000 61,152,000 63,949,000 69,944,000 76,527,000 79,403,000 87,418,000 54,144,000 
        liabilities and shareholders’ equity
      		                                               
        current liabilities:
      		                                               
        accounts payable and accrued liabilities
      		38,254,000 40,260,000 36,840,000 31,588,000 30,648,000 34,221,000                                          
        operating lease liability
      		1,561,000 1,532,000 1,495,000 1,459,000 1,382,000 1,369,000 1,387,000 1,354,000 1,323,000 1,299,000 1,246,000 1,223,000 1,194,000 488,000    605,000 686,000 759,000 270,000 265,000 596,000 594,000 156,000 168,000 857,000 573,000 722,000                   
        total current liabilities
      		39,815,000 41,792,000 38,335,000 33,047,000                                           16,343,000 
        operating lease liability, long-term
      		5,930,000 6,412,000 6,832,000 7,256,000 7,293,000 7,646,000 8,399,000 8,679,000 9,102,000 9,604,000 9,757,000 10,283,000 10,433,000 9,947,000 7,157,000 7,851,000 8,224,000 7,652,000 2,558,000 2,746,000 2,902,000 3,050,000 188,000 323,000 541,000 743,000                      
        other liabilities, long-term
      		3,246,000 3,199,000 3,158,000                                             
        total liabilities
      		48,991,000 51,403,000 48,325,000 40,303,000 39,323,000 43,236,000 38,094,000 39,964,000 31,325,000 36,877,000 34,501,000 38,442,000 32,924,000 32,649,000 22,694,000                                19,165,000 
        shareholders’ equity:
      		                                               
        common shares, without par value; unlimited shares authorized; issued and outstanding: 96,624,123
      		2,421,833,000                                               
        additional paid-in capital
      		264,879,000 228,234,000 223,782,000 213,892,000 208,460,000 199,149,000 188,442,000 176,796,000 163,577,000 156,764,000 137,974,000 138,683,000 140,088,000 142,108,000 136,728,000 133,295,000 119,580,000 117,495,000 69,621,000 67,255,000 65,457,000 45,357,000 43,796,000 42,218,000 41,068,000 40,646,000 39,676,000 39,391,000 38,932,000 38,515,000 37,886,000 37,718,000 36,919,000 36,471,000 35,773,000 35,182,000 34,557,000 34,326,000 34,117,000 33,752,000 33,381,000 33,083,000 32,844,000 29,314,000 30,450,000 30,346,000 30,242,000 
        accumulated deficit
      		-1,347,682,000 -1,245,380,000 -1,140,119,000 -1,049,223,000 -964,517,000 -899,470,000 -833,785,000 -770,995,000 -713,071,000 -665,140,000 -620,397,000 -571,935,000 -524,474,000 -482,747,000 -445,352,000 -408,202,000 -377,044,000 -357,374,000 -331,810,000 -316,365,000 -294,256,000 -278,492,000 -266,169,000 -257,314,000 -257,139,000 -249,655,000 -238,279,000 -229,408,000 -219,401,000 -207,885,000 -199,327,000 -184,944,000 -177,143,000 -173,388,000 -165,323,000 -157,581,000 -150,201,000 -142,681,000 -136,704,000 -128,972,000 -122,956,000 -119,693,000 -115,754,000 -111,801,000 -107,999,000 -103,734,000 -104,958,000 
        accumulated other comprehensive income
      		-1,211,000 335,000 477,000 113,000   1,336,000                                         
        total shareholders’ equity
      		1,337,819,000  559,511,000 633,978,000 703,957,000                                           
        total liabilities and shareholders’ equity
      		1,386,810,000 633,163,000 607,836,000 674,281,000 743,280,000 798,139,000 835,901,000 884,011,000 919,023,000 964,798,000 671,093,000 684,899,000 719,868,000 754,146,000 775,813,000 807,380,000 558,059,000 572,007,000 264,353,000 274,711,000 290,671,000 189,186,000 199,128,000 210,676,000 237,043,000 147,697,000 98,904,000 105,892,000 114,550,000 122,428,000 130,455,000 65,436,000 37,762,000 46,121,000 46,359,000 54,226,000 60,786,000 67,487,000 73,371,000 55,687,000 61,152,000 63,949,000 69,944,000 76,527,000 79,403,000   
        commitments and contingencies
      		                                               
        common shares, without par value; unlimited shares authorized; issued and outstanding: 80,010,790
      		 1,598,571,000                                              
        total shareholders' equity
      		 581,760,000    754,903,000 797,807,000 844,047,000 887,698,000 927,921,000 636,592,000 646,457,000 686,944,000 721,497,000 753,119,000                                 
        subsequent event
      		                                               
        common shares, without par value; unlimited shares authorized; issued and outstanding: 77,120,168
      		  1,475,371,000                                             
        common shares, without par value; unlimited shares authorized; issued and outstanding: 76,939,811
      		   1,469,196,000                                            
        accounts and other receivable
      		    8,649,000                                           
        current assets: - sum
      		    565,537,000 635,264,000 659,639,000 728,089,000 707,204,000 644,962,000 531,008,000 544,616,000 533,351,000 600,298,000 649,176,000 794,803,000 545,616,000 559,020,000 256,314,000 266,755,000 283,260,000 181,783,000 194,810,000 207,010,000 233,870,000 144,866,000 96,478,000 103,325,000 112,047,000 121,437,000 129,493,000 64,350,000 36,661,000 44,821,000 44,987,000 52,633,000 59,141,000 65,675,000 71,350,000 53,392,000 58,268,000 60,866,000      
        current liabilities: - sum
      		    32,030,000 35,590,000 29,695,000 31,285,000 22,223,000 27,273,000 24,744,000 28,159,000 22,491,000 22,702,000 15,537,000 13,736,000 7,982,000 14,322,000 12,856,000 14,982,000 11,492,000 14,781,000 16,917,000 21,055,000 48,524,000 43,379,000 11,697,000 9,330,000 6,376,000 4,119,000 4,413,000 3,094,000 3,788,000 4,083,000 3,058,000 3,774,000 3,591,000 3,516,000 3,976,000 2,929,000 2,872,000 2,782,000      
        common shares, without par value; unlimited shares authorized; issued and outstanding: 76,586,359
      		    1,460,850,000                                           
        accumulated other comprehensive loss
      		    -836,000 -1,612,000  -2,212,000 -1,769,000 -77,000 -2,953,000 -3,299,000 -1,820,000 -3,000,000 -2,955,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000   
        accounts receivable
      		     1,469,000 938,000 853,000 833,000 874,000 805,000 2,123,000 2,222,000 986,000 2,482,000 2,524,000 2,923,000 2,765,000 3,235,000 2,919,000 5,060,000 1,822,000 1,609,000 1,786,000 1,617,000 813,000 209,000 171,000 132,000 256,000 180,000 171,000 432,000 438,000 129,000 198,000 189,000 200,000 595,000 658,000 386,000 315,000 274,000 188,000 1,205,000 215,000 162,000 
        common shares, without par value; unlimited shares authorized; issued and outstanding: 76,416,086
      		     1,456,836,000                                          
        accounts payable and accrued expenses
      		      28,308,000 29,931,000 20,900,000 25,974,000 23,498,000 26,936,000 21,297,000 22,214,000 15,537,000 13,736,000 7,982,000 13,717,000 9,968,000 11,198,000 7,580,000 10,874,000 8,875,000 7,769,000 8,084,000 8,818,000 7,923,000 6,676,000 5,794,000 4,119,000 4,413,000 3,094,000 2,388,000 3,383,000 3,058,000 3,774,000 3,591,000 3,516,000 3,976,000 2,929,000 2,872,000 2,625,000 2,823,000 2,278,000 1,530,000 2,664,000 2,821,000 
        common shares, without par value; unlimited shares authorized; issued and outstanding: 75,794,409
      		      1,441,814,000                                         
        common shares, without par value; unlimited shares authorized; issued and outstanding: 75,667,550
      		       1,440,458,000                                        
        common shares, without par value; unlimited shares authorized; issued and outstanding: 75,459,681
      		        1,438,961,000                                       
        common shares, without par value; unlimited shares authorized; issued and outstanding: 75,370,977
      		         1,436,374,000                                      
        common shares, without par value; unlimited shares authorized; issued and outstanding: 65,002,249
      		          1,121,968,000                                     
        common shares, without par value; unlimited shares authorized; issued and outstanding: 63,718,350
      		           1,083,008,000                                    
        common shares, without par value; unlimited shares authorized; issued and outstanding: 63,107,020
      		            1,073,150,000                                   
        preferred shares, without par value; unlimited shares authorized; issued and outstanding: nil
      		                                               
        common shares, without par value; unlimited shares authorized; issued and outstanding: 62,587,701
      		             1,065,136,000                                  
        collaboration agreements
      		                                               
        common shares, without par value; unlimited shares authorized; issued and outstanding: 62,542,542
      		              1,064,698,000                                 
        common shares, without par value; unlimited shares authorized; issued and outstanding: 62,242,883
      		               1,061,690,000                                
        shareholders’ equity: - sum
      		               785,793,000 541,853,000 550,033,000 248,939,000 256,983,000 276,277,000 171,355,000 182,023,000 189,298,000 187,978,000 91,977,000 74,564,000 82,787,000 92,313,000 103,295,000 111,156,000 50,621,000 28,498,000 35,934,000 43,301,000 50,452,000 57,195,000 63,901,000 69,309,000 52,657,000 58,163,000 61,034,000      
        common shares, without par value; unlimited shares authorized; issued and outstanding: 53,059,049
      		                800,307,000                               
        deferred revenue
      		                  2,202,000 3,025,000 3,642,000 3,642,000 7,446,000 12,692,000 24,608,000 29,743,000                157,000 2,513,000 5,635,000 8,724,000 11,622,000 13,522,000 
        preferred shares, without par value; unlimited shares authorized; issued and outstanding: 1,016,000
      		                 7,732,000 7,732,000 7,732,000 7,732,000 7,732,000 7,732,000 7,732,000 7,732,000 7,732,000 7,732,000 7,732,000 7,732,000 7,732,000                  
        common shares, without par value; unlimited shares authorized; issued and outstanding: 51,634,752
      		                 783,170,000                              
        common shares, without par value; unlimited shares authorized; issued and outstanding: 41,412,875
      		                  504,386,000                             
        common shares, without par value; unlimited shares authorized; issued and outstanding: 41,117,568
      		                   499,351,000                            
        common shares, without par value; unlimited shares authorized; issued and outstanding: 40,962,715
      		                    498,334,000                           
        term loan
      		                        15,676,000 4,650,000                      
        deferred revenue, long-term
      		                         709,000                      
        term loan, long-term
      		                         10,889,000 11,786,000                     
        common shares, without par value; unlimited shares authorized; issued and outstanding: 35,012,125
      		                     397,748,000                          
        subsequent events
      		                                               
        common shares, without par value; unlimited shares authorized; issued and outstanding: 34,994,946
      		                      397,654,000                         
        common shares, without par value; unlimited shares authorized; issued and outstanding: 34,994,790
      		                       397,652,000                        
        common shares, without par value; unlimited shares authorized; issued and outstanding: 34,956,272
      		                        397,307,000                       
        common shares, without par value; unlimited shares authorized; issued and outstanding: 28,139,228
      		                         294,244,000                      
        operating lease liability, current
      		                          158,000 587,000                    
        term loan, current
      		                          3,616,000                     
        common shares, without par value; unlimited shares authorized; issued and outstanding: 25,868,594
      		                          266,425,000                     
        loan payable, current
      		                           2,067,000                    
        loan payable, long-term
      		                           13,202,000 15,139,000 15,014,000 14,886,000 11,721,000 5,476,000 6,104,000              
        common shares, without par value; unlimited shares authorized; issued and outstanding: 25,775,056
      		                           266,062,000                    
        current portion of operating lease liability
      		                            582,000                   
        common shares, without par value; unlimited shares authorized; issued and outstanding: 25,771,954
      		                            266,040,000                   
        loan payable, current portion
      		                                1,400,000 700,000              
        common shares, without par value; unlimited shares authorized; issued and outstanding: 25,750,721
      		                             265,923,000                  
        prepaid expenses, long term
      		                                  218,000 285,000 269,000 408,000 479,000 632,000 1,094,000 1,094,000 1,700,000     
        preferred shares, without par value; unlimited shares authorized; issued and outstanding: 1,568,000
      		                              11,932,000                 
        common shares, without par value; unlimited shares authorized; issued and outstanding: 25,187,441
      		                              261,655,000                 
        preferred shares, without par value; unlimited shares authorized; issued and outstanding: 2,868,000
      		                               21,825,000 21,825,000               
        common shares, without par value; unlimited shares authorized; issued and outstanding: 17,640,951
      		                               177,012,000                
        common shares, without par value; unlimited shares authorized; issued and outstanding: 14,171,301
      		                                147,887,000               
        common shares, without par value; unlimited shares authorized; issued and outstanding: 17,998,420
      		                                 173,841,000 173,841,000 173,841,000            
        common shares, without par value; unlimited shares authorized; issued and outstanding: 17,996,680
      		                                    173,829,000           
        deferred tenant inducements
      		                                     70,000 86,000 101,000 117,000 133,000 149,000 164,000 180,000 196,000 219,000 
        common shares, without par value; unlimited shares authorized; issued and outstanding: 17,930,590
      		                                     173,246,000          
        common shares, without par value; unlimited shares authorized; issued and outstanding: 17,892,933
      		                                      172,886,000         
        common shares, without par value; unlimited shares authorized; issued and outstanding: 14,415,347
      		                                       148,867,000        
        common shares, without par value; unlimited shares authorized; issued and outstanding: 14,401,582
      		                                        148,728,000       
        deferred revenue, less current portion
      		                                             157,000 2,603,000 
        common shares, without par value; unlimited shares authorized; issued and outstanding: 14,385,336
      		                                         148,634,000      
        common shares, without par value; unlimited shares authorized; issued and outstanding: 14,344,267
      		                                          148,359,000     
        fair value of liability classified stock options
      		                                           4,103,000    
        common shares, without par value; unlimited shares authorized; issued and outstanding: 14,267,174
      		                                           147,824,000    
        common shares, without par value; unlimited shares authorized; issued and outstanding: 14,222,275
      		                                            147,508,000   
        deferred financing fees
      		                                              3,876,000 
        redeemable convertible preferred shares
      		                                               
        series a convertible preferred shares, without par value; no shares authorized or outstanding at december 31, 2014; 1,205,761 authorized and 1,151,468 issued and outstanding at december 31, 2013.
      		                                               
        series b convertible preferred shares, without par value; no shares authorized or outstanding at december 31, 2014; 1,028,806 authorized and 994,885 issued and outstanding at december 31, 2013.
      		                                               
        series e convertible preferred shares, without par value; no shares authorized or outstanding at december 31, 2014; 4,370,920 authorized and 4,322,126 issued and outstanding at december 31, 2013.
      		                                               
        shareholders’ equity
      		                                               
        common shares, without par value; unlimited shares authorized; 14,181,333 and 1,344,627 issued and outstanding at december 31, 2014 and december 31, 2013, respectively.
      		                                             147,157,000  
        accumulated comprehensive income
      		                                             -990,000 1,009,000 
        total liabilities, shareholders’ equity (deficit) and redeemable convertible preferred shares
      		                                             87,418,000  
        liabilities and shareholders’ deficit
      		                                               
        contingencies
      		                                               
        redeemable convertible preferred shares:
      		                                               
        series a convertible preferred shares, without par value; 1,205,761 authorized and 1,151,468 issued and outstanding at december 31, 2013 and september 30, 2014, respectively
      		                                              2,939,000 
        series b convertible preferred shares, without par value; 1,028,806 authorized and 994,885 issued and outstanding at december 31, 2013, and september 30, 2014, respectively
      		                                              8,683,000 
        series e convertible preferred shares, without par value; 4,370,920 authorized and 4,322,126 issued and outstanding at december 31, 2013, and september 30, 2014, respectively
      		                                              90,866,000 
        total redeemable convertible preferred shares
      		                                              102,488,000 
        shareholders’ deficit:
      		                                               
        common shares, without par value; unlimited shares authorized; 1,344,627 and 1,349,591 issued and outstanding at december 31, 2013 and september 30, 2014, respectively
      		                                              6,198,000 
        total shareholders’ deficit
      		                                              -67,509,000 
        total liabilities, shareholders’ deficit and redeemable convertible preferred shares
      		                                              54,144,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 
                                                      
          operating activities:
        		                                              
          net loss
        		-102,302,000 -105,261,000 -90,896,000 -84,706,000 -65,047,000 -65,685,000    -44,743,000 -48,462,000 -47,461,000 -41,727,000 -37,395,000 -37,150,000 -31,158,000 -19,670,000 -25,564,000 -15,445,000 -22,109,000 -15,764,000 -12,323,000 -8,855,000 -175,000 -7,484,000 -11,376,000 -8,871,000 -10,007,000 -11,341,000 -8,558,000 -14,383,000 -7,801,000 -3,755,000 -8,065,000 -7,742,000 -7,380,000 -7,517,000  -7,714,000 -6,016,000 -3,263,000      
          adjustments to reconcile net loss to net cash from operating activities:
        		                                              
          interest receivable and accretion of discounts on marketable securities
        		-877,000 687,000 177,000 3,558,000 2,947,000                                          
          depreciation of property plant and equipment
        		587,000   632,000 659,000                                          
          non-cash operating lease expense
        		338,000 334,000 330,000 327,000 322,000                                          
          deferred income tax expense
        		447,000   -170,000 -1,213,000   -333,000 403,000   -224,000 288,000        9,000    52,000                      
          stock-based compensation expense
        		16,894,000  13,705,000 13,713,000 12,174,000                                          
          unrealized foreign exchange loss
        		-204,000 161,000 -60,000 -210,000 182,000 563,000    113,000 -301,000   -725,000 2,962,000   -124,000 440,000 215,000 -204,000   -499,000 522,000 -141,000 64,000 -202,000 -23,000 377,000 -137,000 139,000 267,000     711,000 497,000 -248,000 -2,260,000 1,416,000 3,133,000 -787,000 3,140,000  
          realized loss on marketable securities
        		-400,000 18,000 89,000 0 518,000                                          
          changes in operating assets and liabilities:
        		                                              
          other receivables
        		205,000 -559,000 283,000                                            
          prepaid expenses and other current assets
        		-1,482,000  -3,373,000 -5,486,000 -926,000 -2,229,000 960,000 958,000 -673,000 -2,529,000 -96,000 1,268,000 2,931,000 -6,467,000 -4,467,000 711,000 -272,000 -1,027,000 -141,000 184,000 -533,000 -690,000 196,000 112,000 113,000 -1,028,000                     
          accounts payable and accrued liabilities
        		-1,801,000 3,193,000 5,232,000 869,000 -3,783,000                                          
          operating lease liability
        		-349,000 -335,000 -337,000 -318,000 -307,000                                          
          other liabilities
        		47,000 41,000                                             
          net cash from operating activities
        		-88,897,000 -81,481,000 -71,752,000 -64,233,000 -61,652,000 -54,385,000 -51,147,000 -32,679,000 -43,178,000 -35,465,000 -42,230,000 -33,221,000 -34,411,000 -32,732,000 -30,402,000 -16,868,000 -18,428,000 -20,710,000 -15,007,000 -13,077,000 -20,708,000 -13,114,000 -11,154,000 -10,789,000 -13,067,000 19,735,000 -7,067,000 -8,633,000 -8,667,000 -7,242,000 -13,725,000 -5,538,000 -8,219,000 -6,838,000 -8,626,000 -6,802,000 -6,460,000 -4,670,000 -4,524,000 -5,429,000 -4,944,000 -5,247,000 -4,885,000 -2,424,000 -5,547,000 -2,951,000 
          capital expenditures
        		-133,000 -318,000 -281,000 -157,000 -43,000 -783,000 -590,000 -1,514,000 -188,000 -78,000 -1,200,000 -2,133,000 -2,206,000 -1,752,000 -386,000 -544,000 -212,000 -514,000 -223,000 -909,000 -404,000 -828,000 -793,000 -369,000 -647,000 -595,000 -45,000 -265,000 -335,000 -170,000 -19,000 -137,000 -181,000 -63,000 -14,000 -101,000 -137,000 -28,000 -46,000 -122,000 -83,000 -143,000 -218,000 -106,000 -84,000 -776,000 
          free cash flows
        		-89,030,000 -81,799,000 -72,033,000 -64,390,000 -61,695,000 -55,168,000 -51,737,000 -34,193,000 -43,366,000 -35,543,000 -43,430,000 -35,354,000 -36,617,000 -34,484,000 -30,788,000 -17,412,000 -18,640,000 -21,224,000 -15,230,000 -13,986,000 -21,112,000 -13,942,000 -11,947,000 -11,158,000 -13,714,000 19,140,000 -7,112,000 -8,898,000 -9,002,000 -7,412,000 -13,744,000 -5,675,000 -8,400,000 -6,901,000 -8,640,000 -6,903,000 -6,597,000 -4,698,000 -4,570,000 -5,551,000 -5,027,000 -5,390,000 -5,103,000 -2,530,000 -5,631,000 -3,727,000 
          investing activities:
        		                                              
          purchases of property, plant and equipment
        		-133,000 -318,000 -281,000 -157,000 -43,000 -783,000 -590,000 -1,514,000 -188,000 -78,000 -1,200,000 -2,133,000 -2,206,000 -1,752,000 -386,000 -544,000 -212,000 -514,000 -223,000 -909,000 -404,000 -828,000 -793,000 -369,000 -647,000 -595,000 -45,000 -265,000 -335,000 -170,000 -19,000 -137,000 -181,000 -63,000 -14,000 -101,000 -137,000 -28,000 -46,000 -122,000 -83,000 -143,000 -218,000 -106,000 -84,000 -776,000 
          purchases of marketable securities
        		-505,652,000  -74,702,000 -88,816,000 -131,239,000  -164,088,000 -124,978,000 -176,848,000  -146,765,000 -162,272,000 -108,282,000  -294,755,000 -72,682,000 -68,956,000  -10,001,000 -21,624,000 -100,655,000  -66,787,000 -39,291,000 -107,482,000  -11,888,000                    
          proceeds from marketable securities
        		98,503,000 123,915,000 113,514,000 171,233,000 165,792,000 165,640,000 166,658,000 237,211,000 130,834,000 136,940,000 195,997,000 192,307,000 157,110,000 102,161,000 61,044,000 74,543,000 20,280,000 42,275,000 25,799,000 30,725,000 45,955,000 59,364,000 49,548,000 50,594,000 55,204,000 4,759,000 19,682,000 23,374,000 27,628,000 14,486,000 8,890,000 11,840,000 13,306,000 11,592,000 -75,000 31,715,000 9,384,000     0 8,927,000 243,000 1,575,000 1,736,000 
          net cash from investing activities
        		-407,282,000 62,697,000 38,531,000 82,260,000 34,510,000 98,503,000 1,980,000 110,719,000 -46,202,000 -239,726,000 48,032,000 27,902,000 46,622,000 -14,335,000 -234,097,000 1,317,000 -48,888,000 -215,433,000 15,575,000 8,192,000 -55,104,000 43,199,000 -18,032,000 10,934,000 -52,925,000 -60,266,000 7,749,000 -6,742,000 -7,032,000 -12,556,000 -23,348,000 1,940,000 4,977,000 5,803,000 -89,000 9,333,000 9,247,000 -32,226,000 -111,000 -15,422,000 -83,000 -143,000 8,709,000 137,000 1,491,000 1,040,000 
          financing activities:
        		                                              
          proceeds from offerings
        		837,526,000                                              
          proceeds from exercise of stock options
        		5,487,000 1,386,000 2,360,000 65,000 1,151,000                                          
          net cash from financing activities
        		843,013,000 113,537,000 2,360,000 65,000 1,151,000     324,014,000    6,000 699,000 269,890,000 7,876,000 323,953,000 4,758,000 111,000 118,721,000 45,000 0 -16,720,000 102,470,000 27,431,000 18,000 11,000 58,000 34,000 77,429,000 34,009,000 119,000 6,893,000 0 3,000 174,000 48,000 23,834,000 38,000 44,000 38,000 27,000 86,000 127,000 42,419,000 
          effect of exchange rate changes on cash and cash equivalents
        		-130,000 -104,000 -6,000 632,000 -64,000 -1,157,000 54,000 -202,000 -367,000 246,000 -288,000 359,000 59,000 814,000 -2,698,000 -893,000 293,000 69,000 -447,000 -281,000 67,000 -221,000 87,000 266,000 -725,000 184,000 -104,000 259,000 67,000 -444,000 171,000 -176,000 -163,000 -60,000 313,000 396,000 104,000 -192,000 -274,000 -41,000 2,396,000 -1,466,000 -2,728,000 630,000 -2,180,000 -2,213,000 
          increase in cash and cash equivalents
        		346,704,000     55,091,000 -49,113,000 77,838,000 -89,747,000 49,069,000 35,022,000 -4,960,000 12,270,000 -46,247,000 -266,498,000 253,446,000 -59,147,000 87,879,000 4,879,000 -5,055,000 42,976,000   -16,309,000 35,753,000 -12,916,000 596,000   -20,208,000 40,527,000 30,235,000 -3,286,000   2,930,000 3,065,000          
          cash and cash equivalents, beginning of period
        		199,163,000  0 0 142,712,000  0 0 148,643,000  0 0 57,242,000  0 0 175,688,000  0 0 45,009,000  0 0 24,755,000  0 0 67,754,000  0 0 20,486,000  0 0 17,095,000  0 0 58,651,000  0 0 72,026,000  
          cash and cash equivalents, end of period
        		545,867,000  -30,867,000 18,724,000 116,657,000  -49,113,000 77,838,000 58,896,000  35,022,000 -4,960,000 69,512,000  -266,498,000 253,446,000 116,541,000  4,879,000 -5,055,000 87,985,000  -29,099,000 -16,309,000 60,508,000  596,000 -15,105,000 52,180,000  40,527,000 30,235,000 17,200,000  -8,402,000 2,930,000 20,160,000  18,925,000 -20,854,000 56,064,000  1,123,000 -1,571,000 65,917,000  
          supplemental disclosure of cash paid:
        		                                              
          operating lease
        		439,000  435,000                                            
          supplemental disclosures of non-cash transactions:
        		                                              
          fair value of stock options and pre-funded warrants exercised on a cashless basis
        		17,644,000                                              
          depreciation of property, plant and equipment
        		 611,000                                             
          deferred income tax recovery
        		 -1,114,000    -8,612,000           258,000 346,000 -267,000   -45,000 -188,000   -60,000 -62,000                    
          stock-based compensation
        		     13,599,000 13,002,000 14,716,000 9,400,000 9,182,000 8,743,000 8,453,000 5,994,000 5,812,000 5,742,000 5,208,000 3,614,000 2,705,000 2,643,000 2,704,000 1,965,000 1,610,000 1,580,000 1,472,000 1,015,000 1,357,000 612,000 464,000 491,000 575,000 687,000 700,000 663,000 593,000 567,000 598,000 478,000 519,000 636,000 414,000 592,000 474,000 -191,000 3,158,000 288,000 199,000 
          unrealized fair value gain on trading securities
        		                                              
          prepaid expenses and other assets
        		                                              
          purchase of marketable securities
        		                            -34,325,000 -26,872,000 -32,219,000 -9,763,000 -8,148,000 -5,726,000 0   -32,198,000 -65,000       80,000 
          cash and cash equivalents, beginning of year
        		                                              
          cash and cash equivalents, end of year
        		                                              
          supplemental cash flow disclosure:
        		                                              
          cash paid for operating lease
        		    420,000 427,000 426,000 408,000 411,000 405,000 510,000 303,000 406,000 281,000 228,000 207,000 203,000 205,000 207,000 210,000 202,000 165,000 158,000 152,000 159,000 165,000 155,000 156,000 158,000                  
          cash received for lease incentives
        		         224,000                                     
          supplemental disclosure of non-cash transactions:
        		                                              
          fair value of stock options and warrants exercised on a cashless basis
        		                             13,000                 
          fair value of warrant and pre-funded warrants exercised
        		                                              
          decrease in cash and cash equivalents
        		  -30,867,000 18,724,000 -26,055,000                        -15,574,000          18,925,000 -20,854,000 -2,587,000  1,123,000 -1,571,000 -6,109,000  
          income taxes
        		  1,645,000                                            
          fair value of stock options exercised on a cashless basis
        		  2,243,000 8,239,000 2,085,000 2,865,000 1,356,000 1,497,000 2,587,000 2,067,000 69,000 2,479,000 635,000 406,000 1,676,000 880,000 1,529,000 1,766,000 259,000 876,000 448,000 9,000 2,000 293,000 583,000  345,000 2,000 7,000   36,000 176,000              
          accounts and other receivable
        		    -7,178,000                                          
          supplemental disclosure:
        		                                              
          unrealized fair value loss on trading securities
        		         -146,000 -490,000 -1,036,000 -1,878,000 -2,010,000                                 
          accounts receivable
        		     -547,000 -83,000 -22,000 38,000 -294,000 155,000 43,000 226,000 1,515,000 7,000 390,000 -155,000 481,000 -332,000 2,630,000 -3,238,000 -205,000 182,000 -185,000 -824,000 -599,000 -39,000 -35,000 20,000 -80,000 -8,000 260,000 3,000 -309,000 72,000 -6,000 11,000 393,000 61,000 -273,000 -60,000 -46,000 -92,000 1,027,000 -996,000 -58,000 
          proceeds from public offerings
        		                                              
          supplemental disclosures:
        		                                              
          fair value of pre-funded warrants exercised
        		         11,772,000 9,383,000 7,379,000 7,379,000                                  
          purchases of property, plant and equipment included in accounts payable and accrued liabilities
        		                                              
          right-of-use asset obtained in exchange for new operating lease liability
        		                                              
          items not involving cash:
        		                                              
          accretion of discounts on marketable securities
        		                                              
          depreciation
        		      669,000 659,000 599,000 851,000 1,734,000 602,000 354,000 515,000 358,000 375,000 376,000 270,000 209,000 231,000 196,000 202,000 171,000 167,000 104,000 146,000 104,000 100,000 79,000 141,000 143,000 152,000 150,000              
          accounts payable and accrued expenses
        		      -1,788,000 9,153,000 -5,018,000 2,301,000 -3,357,000 5,581,000 -594,000 6,018,000 2,055,000 5,788,000 -5,799,000 3,758,000 -1,271,000 3,697,000 -3,213,000 1,900,000 1,176,000 -477,000 -577,000 847,000 1,306,000 828,000 1,560,000 -136,000 1,257,000 678,000 -1,016,000 316,000 -645,000 140,000 186,000 -445,000 959,000 177,000 -144,000 -143,000 573,000 760,000 -1,110,000 -96,000 
          issuance of common shares, net of issuance costs
        		                     0 0 0 102,456,000     8,000 73,885,000       0         
          increase in operating lease liability and accounts receivable related to lease incentives claimed in the period
        		          -1,154,000 -102,000 1,482,000     0 0                            
          net income
        		       -57,924,000 -47,931,000                                 -3,937,000 -3,827,000 -3,763,000 -4,225,000 1,224,000 
          unrealized foreign exchange (gain) loss
        		       114,000 4,000                                      
          deferred income tax (recovery) expense
        		                            33,000                  
          deferred revenue
        		                 -2,202,000 -823,000   -3,804,000 -5,246,000 -11,916,000 -5,844,000             0 0 0 -157,000 -2,356,000 -3,122,000 -3,089,000 -3,055,000 -3,883,000 
          issuance of common shares and pre-funded warrants, net of issuance costs
        		         323,979,000    0 0 269,890,000 7,876,000                              
          issuance of common shares pursuant to exercise of stock options
        		             6,000    15,000 28,000 111,000 106,000 45,000 0 23,000 14,000 35,000 18,000 11,000 58,000 26,000 80,000 63,000 119,000 0 0 3,000 174,000 48,000         
          purchases of property, plant and equipment included in accounts payable and accrued expenses
        		                                              
          increase in operating lease right-of-use asset and operating lease liability related to lease amendments
        		                                              
          interest received
        		           3,268,000 3,098,000 2,488,000 2,697,000 1,827,000 1,682,000 1,089,000 891,000 886,000 651,000 1,057,000 867,000 1,019,000 1,172,000 278,000 669,000 560,000 709,000 549,000 229,000 148,000 141,000 196,000 87,000 402,000 55,000 80,000 57,000 92,000 112,000 109,000 282,000 147,000 121,000  
          unrealized foreign exchange gain
        		            -5,000    -142,000     17,000             -766,000 -493,000 -326,000          
          amortization of discount on term loan
        		                     0 0 79,000 137,000 137,000 133,000 130,000 125,000 128,000 -8,000 92,000 72,000              
          loss on repayment of term loan
        		                     0 0                        
          repayment of term loan and repayment fees
        		                     0 0                        
          interest paid
        		                     0 0 133,000 206,000 215,000 234,000 238,000 230,000 223,000 174,000 93,000 71,000              
          unrealized fair value loss on marketable securities
        		               1,288,000 3,362,000                              
          unrealized fair value gain on marketable securities
        		                                              
          unrealized loss on marketable securities
        		                  -20,000 18,000 74,000                          
          proceeds from issuance of common shares and pre-funded warrants, net of issuance costs
        		                  4,730,000 0 118,615,000                          
          unrealized gain on marketable securities
        		                     224,000 304,000 -251,000 -281,000                      
          increase in operating lease right-of-use asset and operating lease liability related to lease amendment
        		                                              
          gain on termination of collaboration agreement
        		                             0 0 0 -4,398,000              
          proceeds from issuance of refinanced term loan, net of issuance costs
        		                             0                 
          issuance of preferred shares in exchange for common shares
        		                             0 0 0 21,825,000              
          conversion of preferred shares to common shares
        		                             4,200,000                 
          termination of teva agreement through cancellation of common shares
        		                             0 0 0 4,470,000              
          proceeds from issuance of second tranche under term loan, net of issuance costs
        		                                              
          prepaid expenses, and other current assets
        		                           133,000 389,000 541,000 -1,276,000 242,000 -435,000 370,000 -347,000 186,000 404,000 -680,000 885,000 284,000 82,000 -1,529,000 94,000 1,000 220,000 -546,000 
          prepaid expenses, long term
        		                              0 0 230,000 -12,000 67,000 -16,000 139,000     606,000     
          proceeds from issuance of term loan, net of issuance costs
        		                                              
          fair value of options exercised on a cashless basis
        		                                 0 0 6,000 19,000 236,000 164,000   200,000 355,000 120,000 69,000  
          depreciation and amortization
        		                                  168,000 169,000 165,000 166,000 167,000 249,000 282,000 284,000 262,000 285,000 207,000 205,000 
          deferred tenant inducements
        		                                     -16,000 -15,000 -16,000 -16,000 -16,000 -15,000 -16,000 -16,000 -16,000 
          deferred financing fees
        		                                              
          issuance of common shares on conversion of subscription rights
        		                                             92,000 
          financing fees included in accounts payable and accrued liabilities
        		                                              
          conversion of convertible preferred shares into common shares
        		                                              
          proceeds from issuance of common shares
        		                                       38,000 44,000 38,000 27,000 86,000 127,000  
          gain on write-off of assets
        		                                              
          non-cash compensation on issuance of subscription rights
        		                                              
          sale of property, plant and equipment
        		                                              
          note payable
        		                                              
          adjustments to reconcile net income to net cash from operating activities:
        		                                              
          adjustments to reconcile net income to net cash provided by (used in) operating activities:
        		                                              
          loss on write-off of assets
        		                                              
          interest accrued on note payable
        		                                              
          foreign exchange loss
        		                                             20,000 
          proceeds from issuance of common shares, net of issuance costs
        		                                              
          gain on write-off and disposal of assets
        		                                              
          deferred financing costs
        		                                              
          supplemental information:
        		                                              
          non-cash transactions:
        		                                              
          fair value of stock options transferred from additional paid-in capital to share capital on exercise