7Baggers
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 
      
                                                 
      assets
                                                 
      current assets:
                                                 
      cash and cash equivalents
    104,514,000 135,381,000 116,657,000 142,712,000 87,621,000 136,734,000 58,896,000 148,643,000 99,574,000 64,552,000 69,512,000 57,242,000 103,489,000 369,987,000 116,541,000 175,688,000 87,809,000 82,930,000 87,985,000 45,009,000 15,100,000 44,199,000 60,508,000 24,755,000 37,671,000 37,075,000 52,180,000 67,754,000 87,962,000 47,435,000 17,200,000 20,486,000 14,688,000 23,090,000 20,160,000 17,095,000 54,135,000 35,210,000 56,064,000 58,651,000 65,469,000 64,346,000 65,917,000 72,026,000 33,731,000 
      marketable securities
    357,754,000 352,164,000 432,972,000 484,193,000 566,394,000 584,801,000 640,706,000 489,439,000 427,100,000 475,048,000 457,531,000 534,845,000 534,696,000 418,251,000 421,399,000 376,086,000 161,816,000 177,593,000 186,718,000 131,988,000 175,827,000 158,555,000 169,163,000 116,603,000 56,932,000 64,726,000 58,249,000 51,552,000 39,166,000 15,835,000 17,878,000 23,181,000 29,084,000 28,606,000 37,867,000 47,051,000 15,356,000 15,528,000    9,354,000 9,464,000 12,015,000 14,205,000 
      other receivables
    812,000 1,097,000                                            
      prepaid expenses and other current assets
    17,057,000 11,610,000 7,259,000 6,890,000 4,686,000 5,701,000 6,769,000 6,006,000 3,529,000 2,893,000 4,086,000 7,225,000 8,509,000 4,041,000 4,753,000 4,481,000 3,454,000 3,313,000 3,497,000 2,964,000 2,274,000 2,470,000 2,582,000 2,695,000 1,666,000 1,353,000 1,486,000 1,875,000 2,185,000 909,000 1,151,000 716,000 1,086,000 739,000 925,000 1,329,000 1,264,000 1,996,000 1,818,000 1,900,000 371,000 465,000 464,000 686,000 171,000 
      total current assets
    480,137,000 500,252,000                                           48,269,000 
      marketable securities, long-term
    92,988,000 137,297,000 141,498,000 127,496,000 149,317,000 129,062,000 185,836,000 292,792,000 112,407,000 112,592,000 160,265,000 128,682,000 113,989,000                                 
      operating lease right-of-use asset
    6,960,000 7,290,000 7,617,000 7,939,000 8,258,000 8,573,000 8,884,000 9,193,000 9,497,000 9,799,000 10,097,000 10,406,000 7,559,000 7,730,000 7,900,000 8,056,000 2,967,000 3,086,000 3,206,000 3,326,000 886,000 1,029,000 832,000 933,000 1,036,000 1,135,000 1,233,000                   
      property, plant and equipment
    8,887,000 9,205,000 9,696,000 10,278,000 10,162,000 10,138,000 9,393,000 9,653,000 10,236,000 9,563,000 7,975,000 6,500,000 4,575,000 4,536,000 4,336,000 4,466,000 4,261,000 4,326,000 3,691,000 3,554,000 2,954,000 2,347,000 2,155,000 1,660,000 1,212,000 1,316,000 1,198,000 991,000 962,000 1,086,000 1,101,000 1,070,000 1,154,000 1,308,000 1,376,000 1,404,000 1,542,000 1,663,000 1,790,000 1,989,000 2,130,000 2,174,000 2,353,000 2,476,000 1,999,000 
      deferred tax assets
    11,750,000 11,049,000 10,879,000 9,666,000 1,054,000 733,000 400,000 802,000 601,000 445,000 221,000 509,000 514,000 311,000 207,000 465,000 811,000 544,000 514,000 523,000 478,000 290,000 186,000 238,000 178,000 116,000 72,000                   
      prepaid expenses, long-term
    7,114,000 9,188,000 8,053,000 7,496,000 7,471,000 7,416,000 7,306,000 7,396,000 7,344,000 7,884,000 7,959,000 7,751,000                    230,000              
      total assets
    607,836,000 674,281,000 743,280,000 798,139,000 835,901,000 884,011,000 919,023,000 964,798,000 671,093,000 684,899,000 719,868,000 754,146,000 775,813,000 807,380,000 558,059,000 572,007,000 264,353,000 274,711,000 290,671,000 189,186,000 199,128,000 210,676,000 237,043,000 147,697,000 98,904,000 105,892,000 114,550,000 122,428,000 130,455,000 65,436,000 37,762,000 46,121,000 46,359,000 54,226,000 60,786,000 67,487,000 73,371,000 55,687,000 61,152,000 63,949,000 69,944,000 76,527,000 79,403,000 87,418,000 54,144,000 
      liabilities and shareholders’ equity
                                                 
      current liabilities:
                                                 
      accounts payable and accrued liabilities
    36,840,000 31,588,000 30,648,000 34,221,000                                          
      operating lease liability
    1,495,000 1,459,000 1,382,000 1,369,000 1,387,000 1,354,000 1,323,000 1,299,000 1,246,000 1,223,000 1,194,000 488,000    605,000 686,000 759,000 270,000 265,000 596,000 594,000 156,000 168,000 857,000 573,000 722,000                   
      total current liabilities
    38,335,000 33,047,000                                           16,343,000 
      operating lease liability, long-term
    6,832,000 7,256,000 7,293,000 7,646,000 8,399,000 8,679,000 9,102,000 9,604,000 9,757,000 10,283,000 10,433,000 9,947,000 7,157,000 7,851,000 8,224,000 7,652,000 2,558,000 2,746,000 2,902,000 3,050,000 188,000 323,000 541,000 743,000                      
      other liabilities, long-term
    3,158,000                                             
      total liabilities
    48,325,000 40,303,000 39,323,000 43,236,000 38,094,000 39,964,000 31,325,000 36,877,000 34,501,000 38,442,000 32,924,000 32,649,000 22,694,000                                19,165,000 
      shareholders’ equity:
                                                 
      common shares, without par value; unlimited shares authorized; issued and outstanding: 77,120,168
    1,475,371,000                                             
      additional paid-in capital
    223,782,000 213,892,000 208,460,000 199,149,000 188,442,000 176,796,000 163,577,000 156,764,000 137,974,000 138,683,000 140,088,000 142,108,000 136,728,000 133,295,000 119,580,000 117,495,000 69,621,000 67,255,000 65,457,000 45,357,000 43,796,000 42,218,000 41,068,000 40,646,000 39,676,000 39,391,000 38,932,000 38,515,000 37,886,000 37,718,000 36,919,000 36,471,000 35,773,000 35,182,000 34,557,000 34,326,000 34,117,000 33,752,000 33,381,000 33,083,000 32,844,000 29,314,000 30,450,000 30,346,000 30,242,000 
      accumulated deficit
    -1,140,119,000 -1,049,223,000 -964,517,000 -899,470,000 -833,785,000 -770,995,000 -713,071,000 -665,140,000 -620,397,000 -571,935,000 -524,474,000 -482,747,000 -445,352,000 -408,202,000 -377,044,000 -357,374,000 -331,810,000 -316,365,000 -294,256,000 -278,492,000 -266,169,000 -257,314,000 -257,139,000 -249,655,000 -238,279,000 -229,408,000 -219,401,000 -207,885,000 -199,327,000 -184,944,000 -177,143,000 -173,388,000 -165,323,000 -157,581,000 -150,201,000 -142,681,000 -136,704,000 -128,972,000 -122,956,000 -119,693,000 -115,754,000 -111,801,000 -107,999,000 -103,734,000 -104,958,000 
      accumulated other comprehensive income
    477,000 113,000   1,336,000                                         
      total shareholders’ equity
    559,511,000 633,978,000 703,957,000                                           
      total liabilities and shareholders’ equity
    607,836,000 674,281,000 743,280,000 798,139,000 835,901,000 884,011,000 919,023,000 964,798,000 671,093,000 684,899,000 719,868,000 754,146,000 775,813,000 807,380,000 558,059,000 572,007,000 264,353,000 274,711,000 290,671,000 189,186,000 199,128,000 210,676,000 237,043,000 147,697,000 98,904,000 105,892,000 114,550,000 122,428,000 130,455,000 65,436,000 37,762,000 46,121,000 46,359,000 54,226,000 60,786,000 67,487,000 73,371,000 55,687,000 61,152,000 63,949,000 69,944,000 76,527,000 79,403,000   
      commitments and contingencies
                                                 
      common shares, without par value; unlimited shares authorized; issued and outstanding: 76,939,811
     1,469,196,000                                            
      accounts and other receivable
      8,649,000                                           
      common shares, without par value; unlimited shares authorized; issued and outstanding: 76,586,359
      1,460,850,000                                           
      accumulated other comprehensive loss
      -836,000 -1,612,000  -2,212,000 -1,769,000 -77,000 -2,953,000 -3,299,000 -1,820,000 -3,000,000 -2,955,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000 -990,000   
      accounts receivable
       1,469,000 938,000 853,000 833,000 874,000 805,000 2,123,000 2,222,000 986,000 2,482,000 2,524,000 2,923,000 2,765,000 3,235,000 2,919,000 5,060,000 1,822,000 1,609,000 1,786,000 1,617,000 813,000 209,000 171,000 132,000 256,000 180,000 171,000 432,000 438,000 129,000 198,000 189,000 200,000 595,000 658,000 386,000 315,000 274,000 188,000 1,205,000 215,000 162,000 
      common shares, without par value; unlimited shares authorized; issued and outstanding: 76,416,086
       1,456,836,000                                          
      total shareholders' equity
       754,903,000 797,807,000 844,047,000 887,698,000 927,921,000 636,592,000 646,457,000 686,944,000 721,497,000 753,119,000                                 
      subsequent event
                                                 
      accounts payable and accrued expenses
        28,308,000 29,931,000 20,900,000 25,974,000 23,498,000 26,936,000 21,297,000 22,214,000 15,537,000 13,736,000 7,982,000 13,717,000 9,968,000 11,198,000 7,580,000 10,874,000 8,875,000 7,769,000 8,084,000 8,818,000 7,923,000 6,676,000 5,794,000 4,119,000 4,413,000 3,094,000 2,388,000 3,383,000 3,058,000 3,774,000 3,591,000 3,516,000 3,976,000 2,929,000 2,872,000 2,625,000 2,823,000 2,278,000 1,530,000 2,664,000 2,821,000 
      common shares, without par value; unlimited shares authorized; issued and outstanding: 75,794,409
        1,441,814,000                                         
      common shares, without par value; unlimited shares authorized; issued and outstanding: 75,667,550
         1,440,458,000                                        
      common shares, without par value; unlimited shares authorized; issued and outstanding: 75,459,681
          1,438,961,000                                       
      common shares, without par value; unlimited shares authorized; issued and outstanding: 75,370,977
           1,436,374,000                                      
      common shares, without par value; unlimited shares authorized; issued and outstanding: 65,002,249
            1,121,968,000                                     
      common shares, without par value; unlimited shares authorized; issued and outstanding: 63,718,350
             1,083,008,000                                    
      common shares, without par value; unlimited shares authorized; issued and outstanding: 63,107,020
              1,073,150,000                                   
      preferred shares, without par value; unlimited shares authorized; issued and outstanding: nil
                                                 
      common shares, without par value; unlimited shares authorized; issued and outstanding: 62,587,701
               1,065,136,000                                  
      collaboration agreements
                                                 
      common shares, without par value; unlimited shares authorized; issued and outstanding: 62,542,542
                1,064,698,000                                 
      common shares, without par value; unlimited shares authorized; issued and outstanding: 62,242,883
                 1,061,690,000                                
      common shares, without par value; unlimited shares authorized; issued and outstanding: 53,059,049
                  800,307,000                               
      deferred revenue
                    2,202,000 3,025,000 3,642,000 3,642,000 7,446,000 12,692,000 24,608,000 29,743,000                157,000 2,513,000 5,635,000 8,724,000 11,622,000 13,522,000 
      preferred shares, without par value; unlimited shares authorized; issued and outstanding: 1,016,000
                   7,732,000 7,732,000 7,732,000 7,732,000 7,732,000 7,732,000 7,732,000 7,732,000 7,732,000 7,732,000 7,732,000 7,732,000 7,732,000                  
      common shares, without par value; unlimited shares authorized; issued and outstanding: 51,634,752
                   783,170,000                              
      common shares, without par value; unlimited shares authorized; issued and outstanding: 41,412,875
                    504,386,000                             
      common shares, without par value; unlimited shares authorized; issued and outstanding: 41,117,568
                     499,351,000                            
      common shares, without par value; unlimited shares authorized; issued and outstanding: 40,962,715
                      498,334,000                           
      term loan
                          15,676,000 4,650,000                      
      deferred revenue, long-term
                           709,000                      
      term loan, long-term
                           10,889,000 11,786,000                     
      common shares, without par value; unlimited shares authorized; issued and outstanding: 35,012,125
                       397,748,000                          
      subsequent events
                                                 
      common shares, without par value; unlimited shares authorized; issued and outstanding: 34,994,946
                        397,654,000                         
      common shares, without par value; unlimited shares authorized; issued and outstanding: 34,994,790
                         397,652,000                        
      common shares, without par value; unlimited shares authorized; issued and outstanding: 34,956,272
                          397,307,000                       
      common shares, without par value; unlimited shares authorized; issued and outstanding: 28,139,228
                           294,244,000                      
      operating lease liability, current
                            158,000 587,000                    
      term loan, current
                            3,616,000                     
      common shares, without par value; unlimited shares authorized; issued and outstanding: 25,868,594
                            266,425,000                     
      loan payable, current
                             2,067,000                    
      loan payable, long-term
                             13,202,000 15,139,000 15,014,000 14,886,000 11,721,000 5,476,000 6,104,000              
      common shares, without par value; unlimited shares authorized; issued and outstanding: 25,775,056
                             266,062,000                    
      current portion of operating lease liability
                              582,000                   
      common shares, without par value; unlimited shares authorized; issued and outstanding: 25,771,954
                              266,040,000                   
      loan payable, current portion
                                  1,400,000 700,000              
      common shares, without par value; unlimited shares authorized; issued and outstanding: 25,750,721
                               265,923,000                  
      prepaid expenses, long term
                                    218,000 285,000 269,000 408,000 479,000 632,000 1,094,000 1,094,000 1,700,000     
      preferred shares, without par value; unlimited shares authorized; issued and outstanding: 1,568,000
                                11,932,000                 
      common shares, without par value; unlimited shares authorized; issued and outstanding: 25,187,441
                                261,655,000                 
      preferred shares, without par value; unlimited shares authorized; issued and outstanding: 2,868,000
                                 21,825,000 21,825,000               
      common shares, without par value; unlimited shares authorized; issued and outstanding: 17,640,951
                                 177,012,000                
      common shares, without par value; unlimited shares authorized; issued and outstanding: 14,171,301
                                  147,887,000               
      common shares, without par value; unlimited shares authorized; issued and outstanding: 17,998,420
                                   173,841,000 173,841,000 173,841,000            
      common shares, without par value; unlimited shares authorized; issued and outstanding: 17,996,680
                                      173,829,000           
      deferred tenant inducements
                                       70,000 86,000 101,000 117,000 133,000 149,000 164,000 180,000 196,000 219,000 
      common shares, without par value; unlimited shares authorized; issued and outstanding: 17,930,590
                                       173,246,000          
      common shares, without par value; unlimited shares authorized; issued and outstanding: 17,892,933
                                        172,886,000         
      common shares, without par value; unlimited shares authorized; issued and outstanding: 14,415,347
                                         148,867,000        
      common shares, without par value; unlimited shares authorized; issued and outstanding: 14,401,582
                                          148,728,000       
      deferred revenue, less current portion
                                               157,000 2,603,000 
      common shares, without par value; unlimited shares authorized; issued and outstanding: 14,385,336
                                           148,634,000      
      common shares, without par value; unlimited shares authorized; issued and outstanding: 14,344,267
                                            148,359,000     
      fair value of liability classified stock options
                                             4,103,000    
      common shares, without par value; unlimited shares authorized; issued and outstanding: 14,267,174
                                             147,824,000    
      common shares, without par value; unlimited shares authorized; issued and outstanding: 14,222,275
                                              147,508,000   
      deferred financing fees
                                                3,876,000 
      redeemable convertible preferred shares
                                                 
      series a convertible preferred shares, without par value; no shares authorized or outstanding at december 31, 2014; 1,205,761 authorized and 1,151,468 issued and outstanding at december 31, 2013.
                                                 
      series b convertible preferred shares, without par value; no shares authorized or outstanding at december 31, 2014; 1,028,806 authorized and 994,885 issued and outstanding at december 31, 2013.
                                                 
      series e convertible preferred shares, without par value; no shares authorized or outstanding at december 31, 2014; 4,370,920 authorized and 4,322,126 issued and outstanding at december 31, 2013.
                                                 
      shareholders’ equity
                                                 
      common shares, without par value; unlimited shares authorized; 14,181,333 and 1,344,627 issued and outstanding at december 31, 2014 and december 31, 2013, respectively.
                                               147,157,000  
      accumulated comprehensive income
                                               -990,000 1,009,000 
      total liabilities, shareholders’ equity (deficit) and redeemable convertible preferred shares
                                               87,418,000  
      liabilities and shareholders’ deficit
                                                 
      contingencies
                                                 
      redeemable convertible preferred shares:
                                                 
      series a convertible preferred shares, without par value; 1,205,761 authorized and 1,151,468 issued and outstanding at december 31, 2013 and september 30, 2014, respectively
                                                2,939,000 
      series b convertible preferred shares, without par value; 1,028,806 authorized and 994,885 issued and outstanding at december 31, 2013, and september 30, 2014, respectively
                                                8,683,000 
      series e convertible preferred shares, without par value; 4,370,920 authorized and 4,322,126 issued and outstanding at december 31, 2013, and september 30, 2014, respectively
                                                90,866,000 
      total redeemable convertible preferred shares
                                                102,488,000 
      shareholders’ deficit:
                                                 
      common shares, without par value; unlimited shares authorized; 1,344,627 and 1,349,591 issued and outstanding at december 31, 2013 and september 30, 2014, respectively
                                                6,198,000 
      total shareholders’ deficit
                                                -67,509,000 
      total liabilities, shareholders’ deficit and redeemable convertible preferred shares
                                                54,144,000 
      revenue:
                                                 
      collaboration revenue
                                                13,192,000 
      royalties
                                                1,000 
      operating expenses:
                                                 
      research and development
                                                3,216,000 
      general and administrative
                                                1,316,000 
      total operating expenses
                                                4,532,000 
      income from operations
                                                8,661,000 
      other income:
                                                 
      interest income
                                                138,000 
      interest expense
                                                 
      foreign exchange gain
                                                392,000 
      gain on write-off and disposal of assets
                                                 
      net income
                                                9,191,000 
      net income attributable to participating securities
                                                5,596,000 
      net income attributable to common shareholders
                                                3,595,000 
      net income per share
                                                 
      basic
                                                2,670 
      diluted
                                                1,690 
      weighted-average shares outstanding:
                                                 
      effects of dilutive securities:
                                                 
      stock options
                                                763,949,000 
      subscription rights
                                                10,400,000 
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