7Baggers

Tandem Diabetes Care, Inc
(NASDAQ:TNDM) 

TNDM stock logo

Tandem Diabetes Care, Inc., a medical device company, designs, develops, and commercializes various products for people with insulin-dependent diabetes in the United States. The company's flagship product is the t:slim X2 insulin delivery system, a pump platform that comprises t:slim X2 pump, its 30...

Founded: 2006
Full Time Employees: 1,043
CEO: John Sheridan  
Sector: Healthcare
Industry: Medical Devices

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Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 
                                                      
      sales
    247,221,000 290,383,000 249,253,000 240,678,000 234,422,000 282,648,000 243,971,000 221,910,000 191,674,000 196,796,000 185,622,000 195,917,000 169,383,000 220,501,000 204,547,000 200,262,000 175,907,000 209,996,000 179,627,000 172,139,000 141,037,000 168,065,000 123,603,000 109,236,000 97,926,000 108,398,000 94,657,000 93,255,000 65,995,000 76,199,000 46,264,000 34,126,000 27,277,000 40,295,000 27,003,000 21,327,000 18,977,000 28,912,000 12,293,000 22,985,000 20,058,000 29,120,000 15,716,000 15,706,000 12,308,000 17,888,176 13,513,716 10,254,640 8,065,468  
      yoy
    5.46% 2.74% 2.17% 8.46% 22.30% 43.62% 31.43% 13.27% 13.16% -10.75% -9.25% -2.17% -3.71% 5.00% 13.87% 16.34% 24.72% 24.95% 45.33% 57.58% 44.02% 55.04% 30.58% 17.14% 48.38% 42.26% 104.60% 173.27% 141.94% 89.10% 71.33% 60.01% 43.74% 39.37% 119.66% -7.21% -5.39% -0.71% -21.78% 46.35% 62.97% 62.79% 16.30% 53.16% 52.60%      
      qoq
    -14.86% 16.50% 3.56% 2.67% -17.06% 15.85% 9.94% 15.77% -2.60% 6.02% -5.25% 15.67% -23.18% 7.80% 2.14% 13.85% -16.23% 16.91% 4.35% 22.05% -16.08% 35.97% 13.15% 11.55% -9.66% 14.52% 1.50% 41.31% -13.39% 64.70% 35.57% 25.11% -32.31% 49.22% 26.61% 12.38% -34.36% 135.19% -46.52% 14.59% -31.12% 85.29% 0.06% 27.61% -31.19% 32.37% 31.78% 27.14%   
      cost of sales
    110,433,000 122,923,000 114,961,000 114,823,000 116,015,000 125,193,000 119,318,000 109,116,000 97,002,000 103,501,000 95,869,000 94,182,000 86,476,000 104,979,000 100,122,000 98,316,000 84,814,000 96,267,000 82,882,000 79,685,000 67,750,000 77,509,000 58,290,000 54,846,000 47,665,000 48,126,000 43,974,000 43,351,000 32,642,000 34,663,000 24,468,000 19,039,000 15,873,000 22,827,000 15,131,000 13,325,000 12,224,000 18,847,000 13,870,000 14,809,000 13,130,000 15,661,000 10,203,000 10,905,000 9,500,000 11,352,731 9,116,570 6,805,890 7,198,810  
      gross profit
    136,788,000 167,460,000 134,292,000 125,855,000 118,407,000 157,455,000 124,653,000 112,794,000 94,672,000 93,295,000 89,753,000 101,735,000 82,907,000 115,522,000 104,425,000 101,946,000 91,093,000 113,729,000 96,745,000 92,454,000 73,287,000 90,556,000 65,313,000 54,390,000 50,261,000 60,272,000 50,683,000 49,904,000 33,353,000 41,536,000 21,796,000 15,087,000 11,404,000 17,468,000 11,872,000 8,002,000 6,753,000 10,065,000 -1,577,000 8,176,000 6,928,000 13,459,000 5,513,000 4,801,000 2,808,000 6,535,445 4,397,146 3,448,750 866,658  
      yoy
    15.52% 6.35% 7.73% 11.58% 25.07% 68.77% 38.88% 10.87% 14.19% -19.24% -14.05% -0.21% -8.99% 1.58% 7.94% 10.27% 24.30% 25.59% 48.13% 69.98% 45.81% 50.25% 28.87% 8.99% 50.69% 45.11% 132.53% 230.77% 192.47% 137.78% 83.59% 88.54% 68.87% 73.55% -852.82% -2.13% -2.53% -25.22% -128.61% 70.30% 146.72% 105.94% 25.38% 39.21% 224.00%      
      qoq
    -18.32% 24.70% 6.70% 6.29% -24.80% 26.31% 10.51% 19.14% 1.48% 3.95% -11.78% 22.71% -28.23% 10.63% 2.43% 11.91% -19.90% 17.56% 4.64% 26.15% -19.07% 38.65% 20.08% 8.22% -16.61% 18.92% 1.56% 49.62% -19.70% 90.57% 44.47% 32.30% -34.71% 47.14% 48.36% 18.50% -32.91% -738.24% -119.29% 18.01% -48.53% 144.13% 14.83% 70.98% -57.03% 48.63% 27.50% 297.94%   
      gross margin %
    55.33% 57.67% 53.88% 52.29% 50.51% 55.71% 51.09% 50.83% 49.39% 47.41% 48.35% 51.93% 48.95% 52.39% 51.05% 50.91% 51.78% 54.16% 53.86% 53.71% 51.96% 53.88% 52.84% 49.79% 51.33% 55.60% 53.54% 53.51% 50.54% 54.51% 47.11% 44.21% 41.81% 43.35% 43.97% 37.52% 35.59% 34.81% -12.83% 35.57% 34.54% 46.22% 35.08% 30.57% 22.81% 36.53% 32.54% 33.63% 10.75%  
      operating expenses:
                                                      
      selling, general and administrative
    108,187,000 113,100,000 108,440,000 109,596,000 113,853,000 105,837,000 99,639,000 94,242,000 90,106,000 85,751,000 79,328,000 97,610,000 89,814,000 97,692,000 84,104,000 80,614,000 73,271,000 71,499,000 64,923,000 66,523,000 58,563,000 54,518,000 50,228,000 50,440,000 49,717,000 45,562,000 44,649,000 40,565,000 34,961,000 32,178,000 29,506,000 22,628,000 20,914,000 21,300,000 20,125,000 22,104,000 22,849,000 19,066,000 20,683,000 21,087,000 21,997,000 20,544,000 19,123,000 19,599,000 19,355,000 20,117,034 18,894,758 18,068,303 18,040,905  
      research and development
    46,035,000 46,066,000 48,715,000 48,118,000 50,215,000 52,200,000 51,107,000 49,326,000 46,244,000 42,604,000 41,970,000 42,933,000 42,160,000 35,585,000 36,798,000 33,571,000 33,160,000 29,492,000 24,102,000 20,499,000 17,961,000 17,376,000 16,094,000 15,987,000 14,117,000 12,567,000 12,038,000 11,204,000 9,389,000 8,797,000 7,999,000 6,456,000 5,975,000 5,751,000 4,914,000 4,866,000 5,130,000 4,345,000 6,154,000 4,142,000 4,169,000 4,135,000 5,093,000 3,873,000 3,863,000 3,921,433 4,508,004 3,698,245 3,663,320  
      acquired in-process research and development expenses
        75,217,000        78,750,000 23,000 31,016,000                                    
      total operating expenses
    154,222,000 159,166,000 157,155,000 177,665,000 239,285,000 158,037,000 150,746,000 143,568,000 136,350,000 128,355,000 121,298,000 140,543,000 210,724,000 133,300,000 151,918,000 114,185,000 106,431,000 100,991,000 89,025,000 87,022,000 76,524,000 71,894,000 66,322,000 66,427,000 63,834,000 58,129,000 56,687,000 51,769,000 44,350,000 40,975,000 37,505,000 29,084,000 26,889,000 27,051,000 25,039,000 26,970,000 27,979,000 23,411,000 26,837,000 25,229,000 26,166,000 24,679,000 24,216,000 23,472,000 23,218,000 24,038,467 23,402,762 21,766,548 21,704,225  
      operating income
    -17,434,000 8,294,000 -22,863,000 -51,810,000 -120,878,000 -582,000 -26,093,000 -30,774,000 -41,678,000 -35,060,000 -31,545,000 -38,808,000 -127,817,000 -17,778,000 -47,493,000 -12,239,000 -15,338,000 12,738,000 7,720,000 5,432,000 -3,237,000 18,662,000 -1,009,000 -12,037,000 -13,573,000 2,143,000 -6,004,000 -1,865,000 -10,997,000 561,000 -15,709,000 -13,997,000 -15,485,000 -9,583,000 -13,167,000 -18,968,000 -21,226,000 -13,346,000 -28,414,000 -17,053,000 -19,238,000 -11,220,000 -18,703,000 -18,671,000 -20,410,000 -17,503,022 -19,005,616 -18,317,798 -20,837,567  
      yoy
    -85.58% -1525.09% -12.38% 68.36% 190.03% -98.34% -17.28% -20.70% -67.39% 97.21% -33.58% 217.08% 733.34% -239.57% -715.19% -325.31% 373.83% -31.74% -865.11% -145.13% -76.15% 770.84% -83.19% 545.42% 23.42% 282.00% -61.78% -86.68% -28.98% -105.85% 19.31% -26.21% -27.05% -28.20% -53.66% 11.23% 10.33% 18.95% 51.92% -8.67% -5.74% -35.90% -1.59% 1.93% -2.05%      
      qoq
    -310.20% -136.28% -55.87% -57.14% 20669.42% -97.77% -15.21% -26.16% 18.88% 11.14% -18.72% -69.64% 618.96% -62.57% 288.05% -20.20% -220.41% 65.00% 42.12% -267.81% -117.35% -1949.55% -91.62% -11.32% -733.36% -135.69% 221.93% -83.04% -2060.25% -103.57% 12.23% -9.61% 61.59% -27.22% -30.58% -10.64% 59.04% -53.03% 66.62% -11.36% 71.46% -40.01% 0.17% -8.52% 16.61% -7.91% 3.75% -12.09%   
      operating margin %
    -7.05% 2.86% -9.17% -21.53% -51.56% -0.21% -10.70% -13.87% -21.74% -17.82% -16.99% -19.81% -75.46% -8.06% -23.22% -6.11% -8.72% 6.07% 4.30% 3.16% -2.30% 11.10% -0.82% -11.02% -13.86% 1.98% -6.34% -2.00% -16.66% 0.74% -33.96% -41.02% -56.77% -23.78% -48.76% -88.94% -111.85% -46.16% -231.14% -74.19% -95.91% -38.53% -119.01% -118.88% -165.83% -97.85% -140.64% -178.63% -258.36%  
      other income, net:
                                                      
      interest income and other income
    3,626,000 3,016,000 2,509,000 -632,000                                               
      interest expense
    -2,204,000 -2,075,000 -2,065,000 -1,905,000 -1,862,000 -1,860,000 -1,865,000 -1,793,000 -1,897,000 -1,803,000 -4,840,000 -1,605,000 -1,634,000 -1,579,000 -1,576,000 -1,537,000 -1,516,000 -1,514,000 -1,511,000 -1,509,000 -1,506,000 -4,775,000 -4,855,000                            
      loss from equity method investments
    -3,865,000 -4,553,000 -2,724,000 -3,375,000 -3,542,000                                              
      total other income
    -2,443,000 -3,612,000 -2,280,000 -5,912,000 -1,211,000 598,000 3,479,000 1,031,000 2,149,000 3,750,000 816,000 4,179,000 4,231,000 -417,000 144,000       -6,675,250 -8,360,000 -17,145,000  -2,117,000 3,175,000 353,000                -862,000 -798,000      
      income before income taxes
    -19,877,000 4,682,000 -25,143,000 -57,722,000 -122,089,000 16,000 -22,614,000 -29,743,000 -39,529,000 -31,310,000 -30,729,000 -34,629,000 -123,586,000 -16,114,000 -47,349,000 -12,950,000 -16,439,000 11,145,000 5,848,000 4,069,000 -5,161,000 17,038,000 -9,369,000 -29,182,000 -14,769,000 2,729,000 -2,829,000                        
      income tax expense
    516,000 5,271,000 -3,978,000 -5,322,000 8,467,000 -739,000 637,000 1,071,000 3,186,000 -1,308,000 2,232,000 1,146,000 287,000 -261,000 1,621,000 2,106,000  337,000 54,000 61,000 -117,000 38,000 39,000  98,000 77,000 72,000                        
      net income
    -20,393,000 -589,000 -21,165,000 -52,400,000 -130,556,000 755,000 -23,251,000 -30,814,000 -42,715,000 -30,002,000 -32,961,000 -35,775,000 -123,873,000 -15,853,000 -48,970,000 -15,056,000 -14,715,000 10,808,000 5,794,000 4,008,000 -5,044,000 17,000,000 -9,408,000 -27,107,000 -14,867,000 2,652,000 -2,901,000 -1,512,000 -22,992,000 3,688,000 -34,245,000 -59,359,000 -32,693,000 -11,406,000 -16,035,000 -21,800,000 -23,792,000 -14,823,000 -29,814,000 -18,325,000 -20,484,000 -12,090,000 -19,585,000 -19,533,000 -21,208,000 -18,466,072 -19,899,396 -19,196,591 -21,961,945  
      yoy
    -84.38% -178.01% -8.97% 70.05% 205.64% -102.52% -29.46% -13.87% -65.52% 89.25% -32.69% 137.61% 741.81% -246.68% -945.18% -475.65% 191.73% -36.42% -161.59% -114.79% -66.07% 541.03% 224.30% 1692.79% -35.34% -28.09% -91.53% -97.45% -29.67% -132.33% 113.56% 172.29% 37.41% -23.05% -46.22% 18.96% 16.15% 22.61% 52.23% -6.18% -3.41% -34.53% -1.58% 1.75% -3.43%      
      qoq
    3362.31% -97.22% -59.61% -59.86% -17392.19% -103.25% -24.54% -27.86% 42.37% -8.98% -7.87% -71.12% 681.39% -67.63% 225.25% 2.32% -236.15% 86.54% 44.56% -179.46% -129.67% -280.70% -65.29% 82.33% -660.60% -191.42% 91.87% -93.42% -723.43% -110.77% -42.31% 81.56% 186.63% -28.87% -26.44% -8.37% 60.51% -50.28% 62.70% -10.54% 69.43% -38.27% 0.27% -7.90% 14.85% -7.20% 3.66% -12.59%   
      net income margin %
    -8.25% -0.20% -8.49% -21.77% -55.69% 0.27% -9.53% -13.89% -22.29% -15.25% -17.76% -18.26% -73.13% -7.19% -23.94% -7.52% -8.37% 5.15% 3.23% 2.33% -3.58% 10.12% -7.61% -24.82% -15.18% 2.45% -3.06% -1.62% -34.84% 4.84% -74.02% -173.94% -119.86% -28.31% -59.38% -102.22% -125.37% -51.27% -242.53% -79.73% -102.12% -41.52% -124.62% -124.37% -172.31% -103.23% -147.25% -187.20% -272.30%  
      other comprehensive income:
                                                      
      unrealized gain on short-term investments
    -1,027,000 -49,000 241,000 -98,000 423,000 -2,500,000 3,948,000 -463,000 -1,296,000 1,806,000 349,000 -298,000 1,749,000 -974,750 -258,000   -612,000 8,000 -51,000 -38,000 -98,000 -69,000 105,000 42,000 -14,000 -60,000 101,000 50,000  -19,000 6,000     1,000 2,000 -6,000 -37,000 20,000 -12,000 -5,000 -39,000 39,000 -10,811 6,529 -1,551 13,833  
      unrealized gain on cash flow hedges
    1,702,000 -19,500 534,000                                                
      foreign currency translation gains
    -1,224,000 708,000 648,000 4,380,000 1,599,000 -3,317,000 1,175,000 145,000     -25,000                                      
      comprehensive loss
    -20,942,000 -164,000 -19,742,000 -48,730,000 -128,534,000 -5,062,000 -18,128,000 -31,132,000 -45,019,000 -48,249,500 -33,974,000 -36,875,000 -122,149,000    -17,160,000    -5,158,000 17,030,000 -9,261,000 -26,819,000 -15,234,000 2,683,000 -2,972,000 -1,391,000 -22,938,000 3,688,000 -34,264,000 -59,353,000 -32,693,000 -11,406,000 -16,035,000 -21,800,000 -23,791,000 -14,821,000 -29,820,000 -18,362,000 -20,464,000 -12,102,000 -19,590,000 -19,572,000 -21,169,000 -18,476,883 -19,892,867 -19,198,142 -21,948,112  
      net income per share
    -0.3  -0.31 -0.78 -1.97 0.01 -0.35 -0.47 -0.65 -0.46 -0.51 -0.55 -1.92 -0.24 -0.76 -0.23 -0.23 0.17 0.09 0.06 -0.08 0.29 -0.15 -0.45 -0.25 0.05 -0.05 -0.03 -0.4 0.26 -0.62 -1.17 -1.82 0.92 -3.09 -0.44 -0.75 -0.48 -0.97 -0.6 -0.68 -0.38 -0.65 -0.65 -0.83 -0.78 -0.85 -0.83 -0.96  
      weighted-average shares used for eps calculation
    68,397 67,285 67,652 67,050 66,404 65,451 65,538 64,994 65,326 64,969 65,117 64,830 64,549 64,146 64,236 64,077 63,880 63,000 63,167 62,717 62,448 60,990 61,529 60,424 59,740 58,507 58,801 58,219 57,771 48,129 55,615 50,948 17,993 5,677 5,190 50,036 31,889 30,570 30,627 30,489 30,294 28,923 30,040 29,902 25,522 23,272 23,472,150 23,097,760 22,936,195  
      litigation and settlement expense
       19,951,000                                               
      loss on extinguishment of debt
            -1,268,000                      -5,313,000                    
      unrealized loss on cash flow hedges
       -612,000                                               
      interest income and other
        4,193,000 4,511,000 5,344,000 2,824,000 5,314,000 5,553,000 5,656,000 5,784,000 5,865,000 3,199,000 1,708,000 769,000 381,000 -47,000 31,000 418,000 272,000 332,000 143,000                            
      foreign currency translation losses
            -1,008,000 -547,250 -1,362,000 -802,000                                       
      change in fair value of common stock warrants
                 44,000 12,000 57,000 34,000 -32,000 -392,000 -272,000 -690,000 2,819,000 -3,648,000 -14,336,000 -1,922,000                          
      foreign currency translation loss
                 -137,250 -524,000 -97,000     -76,000                              
      comprehensive income
                 -12,606,000 -49,752,000 -16,277,000  10,178,000 5,779,000 3,931,000                               
      total other expense
                   -711,000 -1,101,000 -1,593,000 -1,872,000 -1,363,000 -1,924,000    -1,196,000    -11,995,000 3,178,000 -18,536,000 -45,362,000 -17,208,000 -1,815,000 -2,868,000 -2,832,000 -2,566,000 -1,492,000 -1,400,000 -1,272,000 -1,246,000 -860,000 -882,000   -724,237.5 -893,780 -878,793 -1,124,378  
      unrealized loss on short-term investments
                   -1,124,000 -2,517,000                                  
      income tax benefit
                    -1,724,000       -2,075,000                           
      other comprehensive loss:
                                                      
      foreign currency translation gain
                    72,000 -18,000 -23,000 -26,000  128,000 216,000 183,000 -409,000 45,000 -11,000                        
      interest and other income
                           412,000 726,000 814,000 914,000 786,000 757,000 629,000 443,000 299,000 91,000 60,000 60,000 60,000 59,000 38,000 34,000 107,000 118,000 90,000 87,000 61,000 99,000 32,725 29,991 30,784 18,499  
      interest and other expense
                           -3,221,000  -2,000 -60,000 -9,000 -6,000 1,000 -1,401,000 -3,112,000 -3,071,000 -2,896,000 -2,928,000 -2,892,000 -2,625,000 -1,530,000 -1,434,000 -1,379,000 -1,364,000 -950,000 -969,000 -923,000 -897,000 -924,775 -923,771 -909,577 -1,142,877  
      change in fair value of stock warrants
                             -2,712,250 2,321,000 -424,000 -12,746,000 2,548,000 -12,265,000 -42,549,000 -14,228,000                  
      foreign currency translation
                               20,000 4,000                      
      other income
                                                      
      other comprehensive gain or loss:
                                                      
      other comprehensive gain:
                                                      
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 
                                                        
        assets
                                                        
        current assets:
                                                        
        cash and cash equivalents
      179,325,000 90,634,000 91,947,000 64,112,000 53,574,000 69,234,000 49,039,000 47,697,000 58,979,000 58,868,000 79,611,000 130,751,000 127,762,000 172,517,000 123,786,000 114,966,000 93,681,000 71,181,000 112,375,000 98,578,000 120,791,000 94,613,000 129,481,000 222,479,000 74,485,000 51,175,000 46,060,000 38,157,000 40,445,000 41,826,000 32,327,000 50,548,000 62,583,000 13,700,000 12,079,000 27,351,000 40,334,000 44,678,000 17,956,000 30,250,000 40,610,000 43,088,000 43,205,000 45,921,000 62,549,000 31,176,000 35,558,073 64,207,844 76,825,800 124,385,137 
        short-term investments
      390,931,000 202,032,000 227,164,000 251,249,000 315,051,000 369,095,000 424,266,000 404,718,000 408,831,000 409,044,000 418,547,000 376,495,000 391,826,000 444,384,000 484,941,000 520,365,000 541,710,000 552,630,000 482,618,000 446,724,000 392,646,000 390,323,000 335,041,000 203,806,000 85,723,000 125,283,000 110,887,000 93,231,000 85,159,000 87,201,000 81,254,000 35,957,000 9,295,000 479,000 459,000 443,000 3,676,000 8,860,000 16,122,000 24,068,000 27,816,000 28,018,000 38,546,000 51,825,000 53,834,000 36,106,000 44,318,806 30,097,363 33,947,943 5,095,331 
        accounts receivable
      140,672,000 165,491,000 125,940,000 128,443,000 126,561,000 114,585,000 107,188,000 98,117,000 92,965,000 105,555,000 100,318,000 98,714,000 91,393,000 114,717,000 112,805,000 103,763,000 94,133,000 110,725,000 87,462,000 80,212,000 73,673,000 82,195,000 52,104,000 45,031,000 53,962,000 46,585,000 45,325,000 48,438,000 33,027,000 35,193,000 21,689,000 13,914,000 13,043,000 20,793,000 10,582,000 9,029,000 7,687,000 11,172,000 8,198,000 9,426,000 9,093,000 14,055,000 7,006,000 7,473,000 5,226,000 7,652,000 5,842,849 4,362,238 3,423,030 5,298,502 
        inventories
      126,400,000 128,769,000 137,284,000 142,573,000 141,165,000 149,612,000 152,441,000 161,661,000 153,893,000 157,937,000 143,492,000 147,599,000 131,557,000 111,117,000 104,774,000 88,098,000 79,987,000 68,551,000 65,734,000 66,705,000 66,816,000 63,721,000 70,644,000 62,263,000 60,469,000 49,073,000 40,732,000 27,341,000 22,826,000                      
        prepaid and other current assets
      49,772,000 31,217,000 34,609,000 28,440,000 27,084,000 21,965,000 19,892,000 21,195,000 20,525,000 16,585,000 16,176,000 10,745,000 15,381,000 7,241,000 7,997,000 7,852,000 8,953,000 8,433,000 6,758,000 6,066,000 7,770,000 6,383,000 5,023,000 6,100,000 6,234,000 4,025,000 3,594,000 5,989,000 4,571,000 3,769,000 3,035,000 3,012,000 2,936,000 2,191,000 2,887,000 2,487,000 4,489,000 4,187,000 3,814,000 3,445,000 2,852,000 2,280,000 2,614,000 2,170,000 1,960,000 1,904,000 1,438,282 2,634,098 1,947,727 1,830,056 
        total current assets
      887,100,000 618,143,000 616,944,000 614,817,000 663,435,000 724,491,000 752,826,000 733,388,000 735,193,000 747,989,000 758,144,000 764,304,000 757,919,000 849,976,000 834,303,000 835,044,000 818,464,000 811,520,000 754,947,000 698,285,000 661,696,000 637,235,000 592,293,000 539,679,000 280,873,000 276,141,000 246,598,000 213,156,000 186,028,000 187,885,000 162,671,000 128,343,000 114,343,000 64,156,000 55,992,000 65,133,000 79,934,000 92,092,000 70,986,000 90,881,000 102,567,000 106,984,000 110,923,000 124,059,000 139,150,000 90,751,000 101,049,596 114,422,564 128,359,223 148,989,182 
        property and equipment
      83,250,000 83,580,000 77,920,000 77,513,000 79,222,000 78,150,000 81,064,000 78,626,000 77,530,000 76,542,000 75,760,000 73,752,000 74,578,000 68,552,000 72,905,000 58,901,000 49,987,000 50,386,000 49,621,000 48,890,000 50,445,000 50,022,000 49,320,000 44,385,000 37,626,000 32,923,000 28,072,000 22,750,000 17,182,000 17,151,000 17,582,000 18,212,000 18,860,000 19,631,000 20,286,000 21,664,000 20,927,000 18,409,000 17,370,000 16,242,000 15,939,000 15,526,000 14,888,000 14,325,000 12,928,000 12,581,000 12,344,942 12,476,109 10,813,661 9,885,985 
        operating lease right-of-use assets
      95,740,000 96,172,000 98,364,000 98,436,000 101,017,000 85,306,000 87,393,000 88,243,000 88,286,000 87,791,000 89,434,000 91,054,000 104,743,000 110,626,000 116,474,000 126,672,000 131,058,000 27,503,000 29,683,000 31,499,000 33,273,000 19,773,000 21,325,000 21,553,000 23,014,000 15,561,000 16,577,000 17,665,000 10,087,000                      
        equity method investments
      56,486,000 60,351,000 64,904,000 67,628,000 71,005,000 74,545,000                                             
        other long-term assets
      30,818,000 22,866,000 16,521,000 17,342,000 7,464,000 5,166,000 36,447,000 37,246,000 40,036,000 40,336,000 16,571,000 17,566,000 16,905,000 23,631,000 23,838,000 15,958,000 15,768,000 15,728,000 16,028,000 16,576,000 8,859,000 9,385,000 10,050,000 10,622,000 1,814,000 1,485,000 515,000 543,000 353,000 128,000 141,000 145,000 121,000 102,000 160,000 126,000 149,000 107,000 113,000 120,000 107,000 499,000 515,000 676,000  691,000     
        total assets
      1,153,394,000 881,112,000 874,653,000 875,736,000 922,143,000 967,658,000 957,730,000 937,503,000 941,045,000 952,658,000 939,909,000 946,676,000 954,145,000 1,052,785,000 1,047,520,000 1,036,575,000 1,015,277,000 905,137,000 850,279,000 795,250,000 754,273,000 716,415,000 672,988,000 616,239,000 343,327,000 326,110,000 292,647,000 255,081,000 214,698,000 206,294,000 181,606,000 157,994,000 144,699,000 95,346,000 87,977,000 98,543,000 112,714,000 112,392,000 90,334,000 109,190,000 120,642,000 125,119,000 128,518,000 141,334,000 155,125,000 106,464,000 116,564,699 130,017,056 142,388,917 162,215,133 
        liabilities and stockholders’ equity
                                                        
        current liabilities:
                                                        
        accounts payable
      59,860,000 47,067,000 47,481,000 55,838,000 59,801,000 44,730,000 48,754,000 47,776,000 48,143,000 49,586,000 46,142,000 57,080,000 55,231,000 55,730,000 61,531,000 50,661,000 45,341,000 28,032,000 26,973,000 27,504,000 28,184,000 17,805,000 20,499,000 16,371,000 21,783,000 17,745,000 16,314,000 9,268,000 11,206,000 6,824,000 6,198,000 3,646,000 3,751,000 5,150,000 7,605,000 6,624,000 4,890,000 7,513,000 5,607,000 6,841,000 5,974,000 5,234,000 4,018,000 3,999,000 4,087,000 1,949,000 3,046,800 2,520,912 2,053,359 2,352,037 
        accrued expenses
      19,238,000 21,012,000 12,539,000 13,764,000 13,689,000 18,170,000 12,280,000 13,225,000 10,932,000 12,726,000 14,073,000 13,120,000 10,477,000 9,595,000 7,898,000 7,610,000 6,362,000 9,419,000 6,330,000 6,405,000 5,058,000 4,783,000 6,349,000 4,563,000 5,896,000 8,014,000 7,978,000               2,121,000         
        employee-related liabilities
      55,695,000 70,409,000 64,455,000 51,691,000 50,447,000 64,128,000 58,718,000 42,871,000 41,676,000 43,430,000 43,735,000 35,473,000 38,697,000 38,682,000 47,967,000 35,429,000 38,258,000 51,556,000 47,219,000 36,476,000 32,711,000 34,159,000 30,526,000 25,731,000 22,059,000 28,320,000 28,207,000 23,896,000 17,047,000 24,030,000 17,229,000 13,641,000 10,510,000 14,488,000 11,413,000 13,121,000 11,630,000 10,183,000 10,536,000 10,952,000 9,538,000 11,761,000 9,854,000 8,677,000 8,789,000 9,722,000 8,367,716 5,497,815 6,574,937 5,876,011 
        operating lease liabilities
      20,109,000 19,472,000 21,341,000 19,888,000 20,713,000 18,208,000 18,033,000 17,790,000 17,320,000 17,060,000 17,618,000 17,757,000 15,849,000 13,121,000 12,120,000 9,925,000 8,080,000 9,279,000 9,261,000 9,260,000 9,446,000 9,421,000 9,365,000 9,306,000 8,320,000 6,320,000 5,951,000 5,341,000 3,703,000                      
        deferred revenue
      8,954,000 9,527,000 9,844,000 10,516,000 10,977,000 11,831,000 42,567,000 44,200,000 44,562,000 43,994,000 31,610,000 23,401,000 20,764,000 18,837,000 12,974,000 11,713,000 10,881,000 10,182,000 9,022,000 7,953,000 6,670,000 6,082,000 5,210,000 4,642,000 4,377,000 3,869,000 8,187,000 7,139,000 5,460,000 4,600,000 3,703,000 2,964,000 2,875,000 2,526,000 2,295,000 3,821,000 3,746,000 5,208,000 9,436,000 1,763,000 1,681,000 1,822,000 1,952,000 1,038,000 803,000 840,000 638,143 514,309 382,888 411,423 
        other current liabilities
      84,103,000 75,237,000 96,882,000 99,993,000 91,812,000 49,312,000 38,319,000 34,208,000 30,338,000 28,462,000 33,932,000 27,824,000 30,139,000 29,325,000 31,140,000 23,921,000 22,893,000 23,241,000 20,729,000 18,336,000 18,824,000 17,341,000 16,153,000 14,069,000 11,922,000 11,619,000 10,346,000 7,168,000 6,126,000 8,978,000 6,846,000 5,687,000 5,315,000 5,657,000 5,562,000 6,517,000 6,465,000 6,943,000 7,219,000 5,332,000 5,458,000 5,582,000 3,893,000 2,857,000 2,505,000 2,663,000 2,412,812 2,991,219 2,266,892 3,717,412 
        total current liabilities
      247,959,000 242,724,000 252,542,000 251,690,000 288,175,000 247,049,000 259,276,000 240,610,000 192,971,000 195,258,000 187,110,000 174,655,000 171,157,000 165,290,000 173,630,000 139,259,000 131,815,000 131,856,000 119,650,000 108,723,000 103,410,000 103,852,000 105,506,000 114,307,000 99,647,000 99,396,000 100,266,000 84,214,000 76,680,000 66,288,000 58,550,000 42,507,000 43,711,000 36,085,000 29,411,000 30,839,000 29,215,000 31,476,000 34,820,000 27,065,000 24,824,000 26,520,000 22,320,000 18,485,000 18,770,000 18,094,000 15,655,954 13,210,680 13,135,541 14,599,232 
        convertible senior notes, net - long-term
      601,768,000 310,036,000 309,590,000 309,146,000 308,705,000 308,266,000 307,829,000 307,392,000 347,497,000 285,035,000 284,580,000 284,128,000 283,679,000 283,232,000 282,787,000 282,345,000 281,905,000 281,467,000 281,032,000 280,599,000 280,168,000 202,984,000 199,120,000 195,344,000                           
        operating lease liabilities - long-term
      112,858,000 114,967,000 118,353,000 119,974,000 123,048,000 106,421,000 109,479,000 111,392,000 112,732,000 113,572,000 116,012,000 118,400,000 120,867,000 123,524,000 127,109,000 129,802,000 129,195,000 23,922,000 25,680,000 27,376,000 29,011,000 15,914,000 17,893,000 17,632,000 19,547,000 14,063,000 15,258,000 16,608,000 10,685,000                      
        deferred revenue - long-term
      7,994,000 8,474,000 8,823,000 9,575,000 9,858,000 10,455,000 11,196,000 11,736,000 12,299,000 13,331,000 14,089,000 15,305,000 15,886,000 16,874,000 19,143,000 18,343,000 17,531,000                                  
        other long-term liabilities
      50,412,000 49,741,000 52,380,000 52,068,000 37,065,000 32,369,000 32,240,000 32,498,000 32,482,000 31,830,000 24,118,000 24,954,000 23,803,000 23,918,000 23,029,000 17,242,000 17,449,000 34,780,000 34,263,000 32,467,000 28,270,000 27,360,000 23,925,000 21,252,000 16,957,000 17,672,000 10,129,000 8,914,000 6,371,000 4,932,000 3,599,000 8,132,000 8,247,000 7,181,000 6,786,000 6,955,000 7,628,000 5,274,000 3,445,000 3,447,000 3,299,000 2,719,000 2,550,000 2,534,000 2,102,000 1,658,000 1,156,092 861,928 728,735 795,640 
        total liabilities
      1,020,991,000 725,942,000 741,688,000 742,453,000 766,851,000 704,560,000 720,020,000 703,628,000 697,981,000 639,026,000 625,909,000 617,442,000 615,392,000 612,838,000 625,698,000 586,991,000 577,895,000 472,025,000 460,625,000 449,165,000 440,859,000 350,110,000 346,444,000 348,535,000 136,151,000 131,131,000 125,653,000 109,736,000 93,736,000 75,019,000 66,177,000 131,989,000 132,851,000 124,494,000 115,935,000 116,822,000 114,582,000 118,319,000 85,137,000 77,117,000 74,698,000 61,651,000 57,284,000 53,582,000 52,877,000 51,892,000 49,081,423 46,469,589 45,128,344  
        commitments and contingencies
                                                        
        stockholders’ equity:
                                                        
        common stock, 0.001 par value...
      69,000 68,000 68,000 68,000 67,000 66,000 66,000 65,000 65,000 66,000 65,000 65,000 65,000 65,000 64,000 64,000 64,000 64,000 63,000 63,000 63,000 62,000 62,000 61,000 60,000 59,000 59,000 58,000 58,000 57,000 57,000 53,000 47,000 10,000 55,000 50,000 50,000 31,000 31,000 31,000 30,000 30,000 30,000 30,000 30,000 24,000 23,492 23,455 22,978  
        additional paid-in capital
      1,400,218,000 1,402,044,000 1,379,675,000 1,360,251,000 1,333,531,000 1,312,804,000 1,282,354,000 1,260,392,000 1,238,449,000 1,263,997,000 1,237,939,000 1,219,199,000 1,191,843,000 1,170,888,000 1,140,158,000 1,118,168,000 1,089,689,000 1,068,259,000 1,034,980,000 997,190,000 968,450,000 1,025,233,000 1,002,502,000 934,402,000 847,056,000 819,626,000 794,324,000 769,704,000 743,930,000 731,306,000 719,148,000 595,463,000 521,958,000 448,455,000 438,194,000 431,844,000 426,454,000 398,623,000 394,926,000 391,981,000 387,491,000 384,551,000 380,215,000 377,142,000 372,102,000 303,255,000 297,689,896 293,861,259 288,376,702  
        accumulated other comprehensive income
      5,044,000 5,593,000 5,168,000 3,745,000 75,000 -1,947,000 3,870,000 -1,253,000 -935,000 1,369,000        -616,000 14,000 29,000 106,000 220,000 190,000 43,000 -245,000 122,000 91,000 162,000 41,000   6,000      -1,000 -3,000 3,000 40,000 20,000 32,000 37,000 39,000 8,000 18,811 12,282 13,833  
        accumulated deficit
      -1,272,928,000 -1,252,535,000 -1,251,946,000 -1,230,781,000 -1,178,381,000 -1,047,825,000 -1,048,580,000 -1,025,329,000 -994,515,000 -951,800,000 -921,798,000 -888,837,000 -853,062,000 -729,189,000 -713,336,000 -664,366,000 -649,310,000 -634,595,000 -645,403,000 -651,197,000 -655,205,000 -659,210,000 -676,210,000 -666,802,000 -639,695,000 -624,828,000 -627,480,000 -624,579,000 -623,067,000 -600,075,000 -603,763,000 -569,517,000 -510,157,000 -477,613,000 -466,207,000 -450,173,000 -428,372,000 -404,580,000 -389,757,000 -359,942,000 -341,617,000 -321,133,000 -309,043,000 -289,457,000 -269,923,000 -248,715,000 -230,248,923 -210,349,529 -191,152,940  
        total stockholders’ equity
      132,403,000 155,170,000 132,965,000 133,283,000 155,292,000 263,098,000 237,710,000 233,875,000 243,064,000 313,632,000 314,000,000 329,234,000 338,753,000 439,947,000 421,822,000 449,584,000 437,382,000 433,112,000 389,654,000 346,085,000 313,414,000 366,305,000 326,544,000 267,704,000 207,176,000 194,979,000 166,994,000 145,345,000 120,962,000 131,275,000 115,429,000 26,005,000 11,848,000     -5,927,000 5,197,000 32,073,000 45,944,000 63,468,000 71,234,000 87,752,000 102,248,000 54,572,000 67,483,276 83,547,467 97,260,573  
        total liabilities and stockholders’ equity
      1,153,394,000 881,112,000 874,653,000 875,736,000 922,143,000 967,658,000 957,730,000 937,503,000 941,045,000 952,658,000 939,909,000 946,676,000 954,145,000 1,052,785,000 1,047,520,000 1,036,575,000 1,015,277,000 905,137,000 850,279,000 795,250,000 754,273,000 716,415,000 672,988,000 616,239,000 343,327,000 326,110,000 292,647,000 255,081,000 214,698,000 206,294,000 181,606,000 157,994,000 144,699,000     112,392,000 90,334,000 109,190,000 120,642,000 125,119,000 128,518,000 141,334,000 155,125,000 106,464,000 116,564,699 130,017,056 142,388,917  
        current portion of convertible senior notes
          40,736,000 40,670,000 40,605,000 40,540,000                                           
        accumulated other comprehensive loss
                -2,206,000 -1,193,000 -93,000 -1,817,000 -5,064,000 -4,282,000 -3,061,000             -13,000 -13,000                    
        common stock warrants
                       147,000 116,000 2,789,000 2,517,000 14,261,000 17,404,000 39,625,000 25,290,000 23,509,000 23,283,000 25,616,000 29,762,000 17,926,000 20,643,000 12,291,000 18,061,000 5,432,000                 
        patents
                                885,000 967,000 1,048,000 1,130,000 1,212,000 1,294,000 1,375,000 1,457,000 1,539,000 1,620,000 1,704,000 1,784,000 1,865,000 1,947,000 2,029,000 2,110,000 2,192,000 2,274,000 2,355,000 2,441,000 2,459,230 2,538,560 2,617,890 2,697,220 
        deferred rent - long-term
                                                        
        accrued expense
                                 5,786,000 3,376,000 3,930,000 3,931,000 4,278,000 3,199,000 2,832,000 2,536,000 756,000 2,484,000 1,629,000 2,022,000 2,177,000 2,173,000  2,603,000 1,914,000 2,586,000 2,920,000 1,190,483 1,686,425 1,488,681 1,873,565 
        deferred rent—long-term
                                   3,799,000 4,028,000 4,250,000 4,488,000 4,687,000 4,142,000 4,351,000 3,976,000 2,609,000 2,191,000 2,207,000 2,469,000 2,743,000 2,915,000 3,084,000 2,546,000 2,700,000 2,853,814 3,004,629 1,819,222 1,886,508 
        inventory
                                   19,896,000 24,366,000 24,912,000 26,486,000 26,993,000 29,985,000 25,823,000 23,748,000 21,195,000 22,896,000 21,692,000 20,196,000 17,543,000 17,552,000 14,670,000 13,581,000 11,913,000 11,891,586 11,121,021 10,164,723 10,330,156 
        restricted cash - long-term
                                                        
        notes payable—long-term
                                     77,100,000 76,405,000 76,541,000 75,596,000 74,677,000 73,763,000 78,960,000 44,681,000 44,398,000 44,106,000 29,669,000 29,499,000 29,479,000 29,459,000 29,440,000 29,415,563 29,392,352 29,444,846 29,396,571 
        stockholders’ equity
                                                        
        restricted cash—long term
                                                        
        restricted cash - long term
                                     10,000,000 10,000,000 10,000,000                 
        restricted cash
                                           2,000,000 2,000,000 2,000,000 2,000,000 2,000,000 2,000,000 2,000,000 2,000,000 2,000,000 2,000,000 2,000,000 2,050,000 2,050,000 
        liabilities and stockholders’ deficit
                                                        
        stockholders’ deficit:
                                                        
        total stockholders’ deficit
                                       -29,148,000 -27,958,000 -18,279,000 -1,868,000              
        total liabilities and stockholders’ deficit
                                       95,346,000 87,977,000 98,543,000 112,714,000              
        restricted cash—long-term
                                        10,000,000 10,000,000 10,000,000              
        commitments and contingencies:
                                                        
        other long term assets
                                                  692,000  710,931 579,823 598,143 642,746 
        preferred stock, 0.001 par value...
                                                        
        deferred rent—current
                                                      368,784 368,784 
        employee note receivable
                                                        
        liabilities, convertible preferred stock and stockholders’ equity
                                                        
        notes payable—current, net of discounts
                                                        
        preferred stock warrant liability
                                                        
        common stock subject to repurchase
                                                        
        convertible preferred stock:
                                                        
        series a convertible preferred stock, no shares authorized, issued and outstanding at december 31, 2013 and 0.001 par value...
                                                        
        series b convertible preferred stock, no shares authorized, issued and outstanding at december 31, 2013 and 0.001 par value...
                                                        
        series c convertible preferred stock, no shares authorized, issued and outstanding at december 31, 2013 and 0.001 par value...
                                                        
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 
                                                         
          operating activities
                                                         
          net loss
        -20,393,000 -589,000 -21,165,000 -52,400,000 -130,556,000 755,000 -23,251,000 -30,814,000 -42,715,000  -32,961,000 -35,775,000 -123,873,000   -15,056,000 -14,715,000   4,008,000 -5,044,000 17,000,000 -9,408,000 -27,107,000 -14,867,000 2,652,000 -2,901,000 -1,512,000 -22,992,000 3,688,000 -34,246,000 -59,360,000 -32,693,000 -11,406,000 -16,034,000 -21,801,000 -23,792,000 -14,823,000 -29,815,000 -18,325,000 -20,484,000 -12,090,000 -19,586,000 -19,534,000 -21,208,000 -18,466,072 -19,899,394 -19,196,589 -21,961,945 
          adjustments to reconcile net loss to net cash from operating activities:
                                                         
          depreciation and amortization expense
        4,504,000 4,495,000 4,493,000 4,367,000 4,311,000 4,245,000 4,211,000 4,108,000 4,043,000 4,031,000 4,023,000 4,265,000 3,396,000 3,641,000 3,508,000 3,553,000 3,628,000 3,520,000 3,400,000 3,440,000 3,485,000 3,427,000 2,989,000 2,205,000 1,830,000 1,642,000 1,484,000 1,508,000 1,438,000 1,468,000 1,455,000 1,405,000 1,493,000 2,129,000 1,721,000 1,588,000 1,428,000 1,472,000 1,299,000 1,384,000 1,334,000 1,219,000 1,196,000 1,232,000 1,182,000 1,304,226 1,166,586 997,191 920,997 
          amortization of debt issuance costs
        576,000 446,000 444,000 465,000 505,000 502,000 502,000 435,000 650,000 493,000 702,000 506,000 503,000  499,000 458,000 438,000    428,000                             
          provision for expected credit losses
        2,109,000 2,733,000 3,168,000 2,146,000 1,431,000 2,677,000 3,579,000 1,525,000 2,198,000 1,474,000 1,308,000 1,372,000 1,386,000 1,827,000 965,000 1,144,000 846,000 871,000 588,000 731,000 143,000 835,000 652,000 667,000 862,000                         
          operating lease and other impairment charges
         6,697,000                                             
          amortization of discount or (accretion of premium) on short-term investments
        -747,000 -1,745,000                                                
          loss from equity method investments
        3,865,000 4,553,000 2,724,000 3,375,000 3,542,000                                             
          stock-based compensation expense
        15,660,000 20,110,000 21,141,000 25,641,000 25,489,000 28,166,000 26,281,000 24,897,000 22,039,000 22,741,000 20,741,000 23,400,000 21,194,000 24,441,000 22,236,000 20,131,000 18,110,000 17,099,000 15,729,000 14,977,000 12,947,000 13,308,000 12,837,000 16,421,000 15,865,000 18,685,000 17,230,000 12,322,000 9,834,000 10,309,000 9,537,000 2,698,000 1,192,000 2,126,000 2,392,000 5,146,000 2,964,000 2,927,000 2,905,000 3,028,000 2,800,000 3,086,000 2,977,000 3,260,000 3,773,000 3,947,027 3,745,710 3,531,206 3,771,057 
          acquired in-process research and development expenses
         75,217,000     78,750,000 23,000                                    
          other
        1,804,000 3,322,000 617,000 -1,623,000 2,047,000 -2,637,000 1,275,000 283,000 52,000 2,284,000 -1,353,000 -396,000 -20,000 1,679,000 -806,000 -206,000 468,000 678,000 -26,000 -33,000 -73,000 1,000 1,000 17,000 19,000 -363,000 16,000 -1,000 27,000 -3,000 4,000 3,000 148,000 90,000 3,000 2,000 64,000 -41,000 -16,000 14,000 -35,000 -82,000 69,000 -3,000 -60,000     
          changes in operating assets and liabilities:
                                                         
          accounts receivable
        22,680,000 -42,014,000 -1,282,000 -2,673,000 -10,843,000 -12,083,000 -11,574,000 -6,903,000 9,765,000 -5,595,000 -3,681,000 -9,292,000 22,845,000 -3,034,000 -9,718,000 -10,807,000 15,729,000 -24,207,000 -7,819,000 -7,343,000 8,389,000 -31,017,000 -7,770,000 8,242,000 -8,292,000 -2,110,000 2,400,000 -15,809,000 1,821,000 -13,935,000 -8,048,000 -1,522,000 7,657,000 -10,372,000 -1,799,000 -1,452,000 3,178,000 -2,940,000 1,163,000 -562,000 4,590,000 -7,126,000 374,000 -2,178,000 2,457,000 -1,891,927 -1,484,371 -985,823 1,821,121 
          inventories
        1,927,000 7,564,000 5,194,000 2,457,000 9,601,000 595,000 10,372,000 -8,314,000 3,157,000 -13,339,000 3,231,000 -16,029,000 -19,916,000 -5,390,000 -16,710,000 -8,389,000 -11,963,000 -3,024,000 1,035,000 119,000 -3,084,000 6,691,000 -8,871,000 -2,086,000 -11,095,000 -8,985,000 -13,536,000 -4,764,000 -3,690,000                     
          prepaid and other current assets
        -18,997,000 3,052,000 -9,792,000 -84,000 -2,264,000 -2,138,000 1,355,000 -678,000 -4,104,000 -1,843,000 -4,149,000 2,061,000 -5,208,000 -1,422,000 -160,000 783,000 741,000 -1,413,000 -568,000 1,823,000 -1,412,000 -1,345,000 1,019,000 130,000 -2,231,000 -567,000 2,516,000 -1,497,000 -1,036,000 -753,000 -2,000 -76,000 -745,000 698,000 -401,000 2,002,000 -468,000 -1,058,000 -243,000 -593,000 -572,000 315,000 -461,000 -193,000 -56,000 -473,774 1,195,816 -686,371 -117,671 
          other long-term assets
        -8,521,000 -10,473,000 61,000 2,806,000 718,000 453,000 347,000 329,000 -236,000 -1,971,000 443,000 -1,273,000 -386,000 -247,000 -59,000 -319,000 -582,000 1,467,000 5,000 -142,000 -17,000 96,000 27,000 389,000 -383,000 -193,000 28,000 -190,000 -225,000 13,000 4,000 -25,000 -18,000 57,000 -33,000 23,000 -43,000 6,000 7,000 -13,000 -2,000  145,000       
          accounts payable
        13,754,000                    10,537,000 -2,150,000 3,592,000 -4,618,000 4,294,000 1,779,000 4,925,000 -2,170,000 4,376,000 558,000 2,816,000 -79,000 -1,654,000 -2,475,000 969,000 2,278,000 -2,725,000 2,943,000 -1,440,000 711,000 1,020,000 1,131,000 836,000 34,000 1,354,000 -1,840,963 539,188 557,820 -481,045 
          employee-related liabilities
        -14,743,000 5,798,000 12,846,000 1,059,000 -13,708,000 5,559,000 15,762,000 1,192,000 -1,654,000 -404,000 8,282,000 -2,501,000 -210,000 -9,284,000 12,541,000 -2,827,000 -13,299,000 4,338,000 10,743,000 3,766,000 -1,448,000 3,635,000 4,798,000 3,159,000 -6,253,000 112,000 4,313,000 6,842,000 -6,982,000 6,801,000 3,589,000 3,130,000 -3,978,000 3,076,000 -1,709,000 1,059,000 1,447,000 -353,000 -416,000 1,414,000 -2,223,000 1,907,000 1,177,000 -112,000 -933,000 1,354,294 2,869,902 -1,077,122 698,926 
          deferred revenue
        -1,078,000 -686,000 -1,392,000 -1,114,000 -1,596,000 -31,147,000 -2,328,000 -889,000 -372,000 11,483,000 7,096,000 2,021,000 925,000 3,360,000 2,064,000 1,644,000 1,290,000 2,837,000 2,486,000 3,417,000 1,871,000 2,814,000 1,547,000 1,144,000 1,524,000 1,002,000 1,048,000 1,678,000 861,000 896,000 739,000 90,000 349,000 231,000 -2,787,000 73,000 -1,423,000 -3,918,000 8,586,000 83,000 -141,000 -130,000 913,000 235,000 -37,000 202,280 123,834 131,421 -28,535 
          operating leases and other current liabilities
        7,892,000 10,208,000 614,000 3,405,000 4,998,000 10,699,000 2,931,000 3,084,000 883,000 -6,443,000 5,722,000 2,128,000 2,895,000 1,140,000   -1,106,000                                 
          other long-term liabilities
        762,000 -2,139,000 226,000 4,207,000 644,000 634,000 -547,000 78,000 833,000 7,550,000 -836,000 1,150,000 -114,000 890,000 1,126,000 307,000 -391,000 -1,159,000 373,000 2,579,000 -372,000 1,507,000 1,703,000 2,382,000 -1,704,000 2,214,000 1,213,000 2,541,000 1,444,000 1,334,000 430,000 238,000 365,000 356,000 -207,000 -277,000 -262,000 748,000 7,000 111,000 24,000  1,000       
          net cash from operating activities
        11,054,000 9,789,000 8,264,000 -9,496,000 -18,278,000 10,717,000 26,779,000 -5,275,000 -7,996,000 -7,216,000 55,000 -6,323,000 -18,326,000 5,820,000 23,943,000 6,901,000 13,800,000 19,635,000    15,237,000 14,564,000 15,499,000 -20,631,000 19,442,000 23,019,000 3,568,000 -4,124,000 14,133,000 -3,457,000 -6,723,000 -12,272,000 -11,641,000 -19,018,000 -14,665,000 -20,812,000 -13,582,000 -18,154,000 -13,492,000 -15,945,000 -10,246,000 -14,338,000 -18,758,000 -15,422,000 -15,137,160 -13,580,247 -15,700,636 -16,959,957 
          capital expenditures
        -5,426,000 -3,816,000 -4,092,000 -9,328,000 1,230,000 -5,199,000 -4,103,000 -8,175,000 -1,243,000 -5,477,000 -5,400,000 -8,421,000 -4,757,000 -5,709,000 -10,646,000 -12,415,000 -1,090,000 -5,746,000    -4,096,000 -6,760,000 -9,786,000 -6,766,000 -6,749,000 -6,761,000 -1,408,000 -888,000 -1,011,000 -573,000 -514,000 -1,419,000 -244,000 -1,412,000 -2,643,000 -2,743,000 -2,139,000 -2,103,000 -1,945,000 -1,743,000 -1,751,000 -600,000 853,831 -969,374 -2,670,593 -1,619,864 
          free cash flows
        5,628,000 5,973,000 4,172,000 -18,824,000 -17,048,000 5,518,000 22,676,000 -13,450,000 -9,239,000 -12,693,000 -5,345,000 -14,744,000 -23,083,000 111,000 13,297,000 -5,514,000 12,710,000 13,889,000    11,141,000 7,804,000 5,713,000 -27,397,000 12,693,000 23,019,000 -3,193,000 -5,532,000 13,245,000 -4,468,000 -7,296,000 -12,786,000 -13,060,000 -19,262,000 -16,077,000 -23,455,000 -16,325,000 -20,293,000 -15,595,000 -17,890,000 -10,246,000 -16,081,000 -20,509,000 -16,022,000 -14,283,329 -14,549,621 -18,371,229 -18,579,821 
          investing activities
                                                         
          purchases of short-term investments
        -216,130,000 -29,656,000 -29,508,000 -17,046,000 -9,450,000 -12,950,000 -73,637,000 -93,475,000 -84,249,000 -119,834,000 -155,500,000 -126,410,000 -109,115,000 -105,158,000 -132,775,000 -119,000,000 -110,719,000 -190,550,000 -157,258,000 -231,280,000 -154,300,000 -165,108,000 -164,984,000 -157,257,000 -9,727,000 -38,265,000 -52,143,000                       
          proceeds from maturities and redemptions of short-term investments
        26,950,000 56,489,000 54,136,000 81,382,000 65,065,000 67,433,000 58,980,000 96,401,000 83,650,000 130,733,000 112,375,000 140,000,000 163,110,000                                     
          purchases of property and equipment
        -6,268,000 -6,685,000 -4,092,000 -6,206,000 -2,965,000 -3,069,000 -5,239,000 -6,466,000 -4,457,000 -5,199,000 -5,400,000 -7,377,000 -8,828,000 -5,627,000 -13,710,000 -12,117,000 -2,643,000 -5,746,000 -3,095,000 -1,815,000 -3,524,000 -4,096,000 -6,760,000 -9,786,000 -6,766,000 -6,749,000                        
          acquisition of in-process research and development
         -35,124,000 -43,464,000                                             
          net cash from investing activities
        -195,448,000 -14,976,000 20,536,000 58,130,000 9,186,000 5,010,000 -19,896,000 -3,540,000 -5,056,000 -16,584,000 -48,525,000 5,698,000 -26,329,000 35,777,000 -14,163,000 6,357,000 5,197,000 -76,818,000 -39,203,000 -64,761,000 -6,094,000 -59,626,000 -137,825,000 -131,521,000 32,916,000 -20,901,000 -22,171,000 -14,661,000 778,000 -6,591,000 -46,811,000 -27,823,000 -9,514,000 -1,419,000 -244,000 1,838,000 2,607,000 4,575,000 5,828,000 1,681,000 -1,636,000 8,860,000 11,529,000 305,000 -18,273,000 9,109,015 -15,146,491 1,193,605 -30,626,129 
          financing activities
                                                         
          proceeds from issuance of convertible senior notes due 2032, net of 8,843 debt issuance costs
        291,157,000                                                 
          payment for capped call transactions related to convertible senior notes due 2032
        -15,300,000                                                 
          cash used to settle withholding taxes on vested restricted stock, net of proceeds from issuance of common stock under company stock plans
        -1,696,000 2,604,000 -1,570,000 1,047,000 -4,688,000                                             
          net cash from financing activities
        274,161,000 2,604,000 -1,570,000 -39,713,000 -4,688,000 2,302,000 -4,519,000 -3,002,000 13,586,000 2,617,000 -1,911,000 3,948,000 -541,000 6,100,000 -774,000 8,051,000 3,500,000 15,886,000 18,850,000 13,623,000 3,573,000 9,204,000 29,931,000 263,822,000 11,481,000 6,418,000 7,034,000 8,793,000 1,962,000 1,957,000 22,047,000 22,511,000 70,669,000 14,681,000 3,990,000 -156,000 13,861,000 35,729,000 32,000 1,451,000 15,103,000 1,269,000 93,000 1,825,000 65,068,000 1,646,209 76,967 1,889,075 26,749 
          effect of foreign exchange rate changes on cash
        -1,076,000 1,270,000 605,000 1,617,000 -1,880,000 2,166,000 -1,022,000 535,000 -423,000 440,000 -759,000 -334,000 441,000 1,034,000 -186,000 -24,000 3,000 103,000 6,000 30,000 14,000 317,000 332,000 194,000 -456,000 155,000 21,000                       
          net increase in cash and cash equivalents
        88,691,000 -1,313,000 27,835,000 10,538,000 -15,660,000 20,195,000 1,342,000 -11,282,000 111,000 -20,743,000 -51,140,000 2,989,000 -44,755,000 48,731,000 8,820,000 21,285,000 22,500,000 -41,194,000 13,797,000 -22,213,000 26,178,000 -34,868,000 -92,998,000 147,994,000 23,310,000             26,722,000 -12,294,000 -10,360,000 -2,478,000 -117,000 -2,716,000 -16,628,000 31,373,000   -12,617,956 -47,559,337 
          cash and cash equivalents at beginning of period
        90,634,000 69,234,000 58,868,000 172,517,000 71,181,000 94,613,000  51,175,000         44,678,000 43,088,000 31,176,000 -137 124,385,137 
          cash and cash equivalents at end of period
        179,325,000 -1,313,000 27,835,000 10,538,000 53,574,000 20,195,000 1,342,000 -11,282,000 58,979,000 -20,743,000 -51,140,000 2,989,000 127,762,000 48,731,000 8,820,000 21,285,000 93,681,000 -41,194,000 13,797,000 -22,213,000 120,791,000 -34,868,000 -92,998,000 147,994,000 74,485,000         1,621,000 -15,272,000 -12,983,000 40,334,000 26,722,000 -12,294,000 -10,360,000 40,610,000 -117,000 -2,716,000 -16,628,000 62,549,000 -4,382,073 -28,649,771 -12,617,956 76,825,800 
          supplemental disclosures of cash flow information
                                                         
          income taxes (refunded) paid
        -290,000                                                 
          supplemental schedule of non-cash investing and financing activities
                                                         
          operating lease right-of-use assets obtained in exchange for operating lease obligations
        1,853,000   1,820,000 -289,000 876,000 1,489,000 2,294,000     3,023,000 465,000                                   
          purchases of property and equipment included in accounts payable and accrued expenses
        842,000 2,869,000                                                
          intangible costs in other long-term liabilities
        13,300,000                                                 
          loss on extinguishment of debt
             1,268,000                                        
          accrued expenses
                            278,000 -1,577,000 1,776,000 -1,331,000 -2,124,000 31,000                        
          purchases of equity investments, strategic investments, and intangible assets
                                                         
          proceeds from issuance of convertible senior notes due 2029, net of 9,400 debt issuance costs
             306,850,000                                         
          repurchase of 246,740 principal amount of convertible senior notes due 2025
             -246,123,000                                         
          principal payments on convertible senior notes due 2025
                                                       
          payment for capped call transactions related to convertible senior notes due 2029
             -15,813,000                                         
          repurchase and retirement of common stock
             -30,000,000                                         
          other financing activities
             183,000    -405,000                                   
          interest paid
                     2,157,000                4,964,000 1,057,000 2,405,000 2,379,000 2,005,000 1,989,000 1,956,000 1,926,000 1,196,000 1,106,000 1,090,000 1,009,000 729,000 881,000 872,000 863,000 568,583 881,667 2,968,750 -1,050,000 
          income taxes paid
         117,000 47,000 3,333,000 1,559,000 1,800,000 115,000 914,000 269,000 152,000 1,402,000 369,000 249,000 -8,000 170,000 63,000 197,000 -15,000 61,000 40,000 91,000                    18,000     
          accounts payable and accrued expenses
          -9,330,000 -898,000 6,637,000 -1,440,000 -1,193,000 3,610,000 -3,369,000  -10,131,000 6,476,000 -919,000      -1,103,000                               
          intangible costs in other long term-liabilities
                                                        
          accretion (amortization) of discount or premium on short-term investments
           -632,000 -1,148,000 -1,726,000   -434,000                                         
          purchases of property and equipment included in accounts payable
           -3,122,000 4,195,000 -2,130,000 1,136,000 -1,709,000 3,214,000 -278,000                                        
          operating lease termination and other impairment charges
                                                       
          losses from equity method investee
                                                         
          acquisitions, including in-process research and development, net of cash acquired
                                                        
          proceeds from issuance of common stock under company stock plans, net of cash used to settle withholding taxes on vested restricted stock
             2,302,000 -4,519,000 -3,002,000 -1,511,000                                         
          purchases of intangible assets and strategic investments
                 -22,284,000                                       
          accretion of discount or premium on short-term investments
                                                         
          adjustments to reconcile net income to net cash from operating activities:
                                                         
          intangible costs in accounts payable
                                                         
          net income
                     -15,853,000    10,808,000                                
          operating lease termination and impairment charges
                                                         
          amortization of premium on short-term investments
                 410,000 1,422,000 1,443,000 312,000    562,000                                 
          proceeds from issuance of common stock under company stock plans
                 2,617,000 -1,840,000   6,100,000 -369,000 8,254,000 3,484,000 15,887,000 18,695,000 13,623,000 3,135,000 9,189,000 29,032,000 17,171,000 11,474,000 6,418,000 7,033,000 8,531,000 1,898,000                     
          proceeds from exercise of common stock warrants
                     67,000 16,000 -1,000 155,000 438,000 15,000 899,000 2,029,000 7,000 1,000 262,000 64,000                     
          provision for inventory obsolescence
                  196,000 22,000 114,000  134,000 295,000 346,000        -363,000                         
          operating lease impairment charge
                                                        
          acquisition, including in-process research and development, net of cash acquired
                   -69,496,000 -23,000                                    
          purchase of property and equipment included in accounts payable
                   -1,044,000 4,071,000 -82,000 3,064,000 -298,000 1,553,000                                 
          intangible costs in accounts payable and other long-term liabilities
                    515,000 -514,000 1,029,000    2,244,000 -104,000                           
          purchase of strategic investment
                    -2,000,000                                     
          proceeds (payments of tax withholdings) related to issuance of common stock under company stock plans
                    -541,000                                     
          amortization of debt discount and issuance costs
                         435,000 433,000                               
          lease termination and impairment charges
                                                         
          change in fair value of common stock warrants
                     -44,000 -12,000 -57,000 -34,000 32,000 392,000 272,000 690,000 -2,819,000 3,648,000 14,336,000 1,922,000 226,000 -2,321,000 424,000 12,746,000 -2,548,000 12,265,000 42,549,000 14,228,000                 
          amortization of premium (discount) on short-term investments
                     806,000 1,582,000      209,000     -263,000 -136,000 -72,000 -94,000 -244,000       -13,000    17,000         
          benefit for deferred income taxes
                                                       
          proceeds from issuance of convertible senior notes, net of 8,809 debt issuance costs
                                                       
          payment for capped call transactions related to convertible senior notes
                                                         
          proceeds from maturities of short-term investments
                      162,200,000 127,303,000 111,559,000 118,478,000 118,650,000 168,407,000 140,200,000 98,213,000 28,000,000 23,850,000 30,859,000 18,413,000                        
          proceeds from sales of short-term investments
                      4,159,000 10,686,000 7,000,000 1,000,000 2,500,000 9,258,000 11,530,000 11,365,000 6,000,000 16,477,000 18,550,000 5,700,000                        
          acquisition of intangible assets and strategic investments
                                                         
          accounts payable & accrued expenses
                       6,461,000 13,732,000                                 
          operating leases & other current liabilities
                                                         
          acquisition of intangible assets and equity investments
                                                       
          right-of-use assets obtained in exchange for operating lease obligations
                        107,478,000 104,000 15,087,000 2,217,000 8,805,000 190,000 8,392,000 3,053,000                     
          provision (recovery) for inventory obsolescence
                            64,000 52,000 -28,000                           
          property and equipment included in accounts payable
                         89,000 493,000 -472,000 924,000 -536,000 641,000 -903,000 1,880,000 -350,000 2,245,000 109,000 130,000  -35,000 -125,000 217,000  12,000 -169,000 229,000  207,000 154,000 441,000  -876,000 -128,000 1,638,000 743,090 -13,286 -90,283 149,479 
          provision for (recovery of) inventory obsolescence
                          68,000                               
          amortization of discount on short-term investments
                          223,000    -319,000 -1,061,000 -66,000       239,000 59,000     -40,000           
          other current liabilities
                          2,391,000 76,000 1,094,000 766,000 2,595,000 1,997,000 431,000 1,881,000 3,385,000 1,070,000 -2,120,000 2,119,000 1,149,000 307,000 -356,000 861,000 249,000 -468,000 -382,000 -775,000 945,000 542,000 -139,000 1,729,000 242,000 113,000 -160,000 247,330 -579,840 34,830 -1,277,320 
          intangible costs in other current and other long-term liabilities
                                                        
          adjustments to reconcile net loss to net cash provided (used) by operating activities:
                                                         
          net cash provided (used) by operating activities
                           28,895,000 28,685,000                             
          amortization of debt discount and debt issuance costs
                             3,863,000 3,776,000                           
          acquisition of intangible assets
                             -81,000                           
          purchase of capped call options related to convertible senior notes
                                                       
          principal payments on notes payable
                                                      
          proceeds from public offerings, net of offering costs
                                                         
          cash and cash equivalents and restricted cash at beginning of period
                                 41,826,000 23,700,000                 
          interest expense related to amortization of debt discount and debt issuance costs
                                     334,000 695,000 692,000 545,000 521,000 523,000 294,000 80,000 52,000 64,000 78,000 29,000 38,000 36,000 35,000 43,192 42,104 40,827 92,877 
          payment in kind interest accrual of notes payable
                                         421,000 419,000 412,000 405,000 252,000 235,000 228,000 212,000         
          provision for allowance for doubtful accounts
                                 854,000 671,000 455,000 342,000 431,000 272,000 386,000 359,000 160,000 247,000 110,000 307,000 -34,000 65,000 229,000 372,000 78,000 92,000 -69,000 -31,000 83,274 3,760 46,615 54,351 
          provision for inventories reserve
                                 845,000 490,000 339,000 679,000                     
          net increase in cash and cash equivalents and restricted cash
                                 5,114,000 7,903,000 -2,285,000 -1,384,000 9,499,000 -28,221,000 -12,035,000 48,883,000                 
          cash and cash equivalents and restricted cash at end of period
                                   -2,288,000 40,445,000 9,499,000 -28,221,000 -12,035,000 72,583,000                 
          lease incentive - lessor-paid tenant improvements
                                         255,000 253,000 1,011,000 1,773,000             
          debt discount included in other long-term liabilities
                                       4,137,000 827,000 21,000 21,000 1,536,000 2,559,000             
          common stock warrants issued in connection with term loan
                                         3,331,000             
          unsettled purchase of investments classified as cash equivalents in other current liabilities
                                                         
          deferred rent
                                     -214,000 -212,000 -174,000 -185,000 -267,000 -159,000 -104,000 -162,000 567,000 -113,000 -243,000 -210,000 -162,000 -161,000 -157,000 -151,000 -1,750,451 -149,382 1,506,119 -67,286 
          proceeds from public offering, net of offering costs
                                     108,921,000 -149,000 64,157,000 14,681,000 3,990,000 -460,000 21,595,000     11,000 64,851,000     
          accrued expense
                                   2,404,000 -553,000 -1,000 -348,000 1,080,000 366,000 296,000 1,780,000 -1,728,000 855,000  -222,000 42,000 36,000  673,000 -673,000 -260,000 1,656,082 -495,943 197,745 -384,884 
          proceeds from maturities and sales of short-term investments
                                                         
          purchase of property and equipment
                                   -6,761,000 -1,408,000 -888,000 -1,011,000 -573,000 -514,000 -1,419,000 -244,000 -1,412,000 -2,643,000 -2,743,000 -2,139,000 -2,103,000 -1,945,000  -1,743,000 -1,751,000 -600,000 853,831 -969,374 -2,670,593 -1,619,864 
          supplemental schedule of noncash investing and financing activities
                                                         
          purchase of short-term investments
                                    -42,914,000  -60,050,000 -31,500,000 -9,000,000     -4,732,000 -3,233,000 -9,216,000 -13,441,000 -12,720,000 -8,478,000 -19,894,000 -39,099,000 -5,245,016 -26,027,117 -6,995,802 -28,833,065 
          proceeds from sales and maturities of short-term investments
                                    45,100,000 17,300,000 14,250,000   3,250,000 5,250,000 12,050,000 11,200,000 13,000,000 13,750,000 23,250,000 21,750,000 21,950,000 21,500,000 13,500,000 11,850,000   
          effect of foreign exchange rates on cash
                                    3,000                     
          public offering costs included in accounts payable
                                        129,000    374,000             
          provision for inventory reserve
                                     210,000 213,000 77,000 107,000 -290,000 51,000 134,000 131,000 1,538,000    87,000 216,000   -246 -96,858 260,104 
          inventory
                                     4,004,000 794,000 1,616,000 342,000 3,144,000 -4,241,000 -2,182,000 -2,615,000 206,000 -3,002,000 -1,486,000 -2,622,000 -97,000 -3,095,000 -1,234,000 -1,658,000 -47,662 -764,582 -819,671 -188,085 
          issuance of notes payable, net of issuance costs
                                             35,000,000 14,994,000       
          property and equipment included in accounts payable & other current liabilities
                                                         
          proceeds from exercise of warrants
                                      372,000 22,652,000 6,512,000                 
          proceeds from common stock issued under employee benefit plans
                                      465,000                   
          proceeds from exercise of common stock
                                                         
          amortization of (discount) premium on short-term investments
                                                         
          purchase of patents
                                                 -74,000 200 -173,200 
          restricted cash in connection with notes payable
                                         -8,000,000             
          proceeds from issuance of common stock
                                         304,000 266,000 729,000 32,000 1,451,000 109,000 1,269,000 93,000 1,814,000 217,000 1,646,209 76,967   
          net decrease in cash and cash equivalents
                                          -15,272,000 -12,983,000 -4,344,000             
          restricted cash in connection with notes payable and corporate credit card
                                                       
          patent included in accrued expense
                                                         
          debt issuance cost included in other long-term liabilities
                                              2,000 452,000         
          gain on disposal of property and equipment
                                                         
          change in fair value of common and preferred stock warrants
                                                         
          amortization of premium/discount on short-term investments
                                                 25,000 16,000 -19,000 -18,000 -20,287    
          other long term assets
                                                    -17,000     
          other long term liabilities
                                                    366,000  268,195 133,193 -66,905 
          purchase of property and equipment, net of gain on sale of property and equipment
                                                         
          proceeds from issuance of preferred stock for cash, net of offering costs
                                                         
          common and preferred stock warrants issued, including incremental value of modification of warrants
                                                         
          conversion of preferred stock warrants into common stock warrants
                                                         
          conversion of convertible preferred stock into common stock
                                                         
          lease incentive—lessor-paid tenant improvements
                                                        
          accretion of discount on notes payable and convertible notes
                                                         
          payments received on note receivable from employees
                                                         
          issuance of convertible notes payable
                                                         
          proceeds from initial public offering, net of offering costs
                                                         
          conversion of notes payable and accrued interest for series d convertible preferred stock
                                                         
          restricted cash
                                                         
          issuance of preferred stock for cash, net of offering costs
                                                         
          deferred initial public offering costs
                                                         
          unrealized gain on short-term investments
                                                      6,529 -1,551 13,833 
          deferred initial public offering costs included in accounts payable
                                                         
          loss on disposal of property and equipment
                                                         
          amortization of discount on short-term investment
                                                        -5,714 
          proceeds from issuance of common stock for cash and exercise of common stock options
                                                        26,749 
          taxes paid
                                                        -87,853 
          common warrants issued
                                                         
          repayment of note receivable from officer