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Unit: USD	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-12-31	2014-09-30	2014-06-30	2014-03-31

operating activities
net income	-21,165,000	-52,400,000	-130,556,000	755,000	-23,251,000	-30,814,000	-42,715,000	-30,002,000	-32,961,000	-35,775,000	-123,873,000	-15,853,000	-48,970,000	-15,056,000	-14,715,000	10,808,000	5,794,000	4,008,000	-5,044,000	17,000,000	-9,408,000	-27,107,000	-14,867,000	2,652,000	-2,901,000	-1,512,000	-22,992,000	3,688,000	-34,246,000	-59,360,000	-32,693,000	-11,406,000	-16,034,000	-21,801,000	-23,792,000	-14,823,000	-29,815,000	-18,325,000	-20,484,000	-12,090,000	-19,586,000	-19,534,000	-21,208,000	-18,466,072	-19,899,394	-19,196,589	-21,961,945
adjustments to reconcile net income to net cash from operating activities:
depreciation and amortization expense	4,493,000	4,367,000	4,311,000	4,245,000	4,211,000	4,108,000	4,043,000	4,031,000	4,023,000	4,265,000	3,396,000	3,641,000	3,508,000	3,553,000	3,628,000	3,520,000	3,400,000	3,440,000	3,485,000	3,427,000	2,989,000	2,205,000	1,830,000	1,642,000	1,484,000	1,508,000	1,438,000	1,468,000	1,455,000	1,405,000	1,493,000	2,129,000	1,721,000	1,588,000	1,428,000	1,472,000	1,299,000	1,384,000	1,334,000	1,219,000	1,196,000	1,232,000	1,182,000	1,304,226	1,166,586	997,191	920,997
amortization of debt issuance costs	444,000	465,000	505,000	502,000	502,000	435,000	650,000	493,000	702,000	506,000	503,000		499,000	458,000	438,000				428,000
benefit from expected credit losses	3,168,000	2,146,000	1,431,000	2,677,000	3,579,000	1,525,000	2,198,000	1,474,000	1,308,000	1,372,000	1,386,000	1,827,000	965,000	1,144,000	846,000	871,000	588,000	731,000	143,000	835,000	652,000	667,000	862,000
operating lease and other impairment charges	0	0	6,697,000
amortization of discount or (accretion of premium) on short-term investments
income from equity method investments	2,724,000	3,375,000	3,542,000
stock-based compensation expense	21,141,000	25,641,000	25,489,000	28,166,000	26,281,000	24,897,000	22,039,000	22,741,000	20,741,000	23,400,000	21,194,000	24,441,000	22,236,000	20,131,000	18,110,000	17,099,000	15,729,000	14,977,000	12,947,000	13,308,000	12,837,000	16,421,000	15,865,000	18,685,000	17,230,000	12,322,000	9,834,000	10,309,000	9,537,000	2,698,000	1,192,000	2,126,000	2,392,000	5,146,000	2,964,000	2,927,000	2,905,000	3,028,000	2,800,000	3,086,000	2,977,000	3,260,000	3,773,000	3,947,027	3,745,710	3,531,206	3,771,057
loss on extinguishment of debt				0	0	0	1,268,000																					0
acquired in-process research and development expenses	0	0	75,217,000					0	0	0	78,750,000	23,000
other	617,000	-1,623,000	2,047,000	-2,637,000	1,275,000	283,000	52,000	2,284,000	-1,353,000	-396,000	-20,000	1,679,000	-806,000	-206,000	468,000	678,000	-26,000	-33,000	-73,000	1,000	1,000	17,000	19,000	-363,000	16,000	-1,000	27,000	-3,000	4,000	3,000	148,000	90,000	3,000	2,000	64,000	-41,000	-16,000	14,000	-35,000	-82,000	69,000	-3,000	-60,000
changes in operating assets and liabilities:
accounts receivable	-1,282,000	-2,673,000	-10,843,000	-12,083,000	-11,574,000	-6,903,000	9,765,000	-5,595,000	-3,681,000	-9,292,000	22,845,000	-3,034,000	-9,718,000	-10,807,000	15,729,000	-24,207,000	-7,819,000	-7,343,000	8,389,000	-31,017,000	-7,770,000	8,242,000	-8,292,000	-2,110,000	2,400,000	-15,809,000	1,821,000	-13,935,000	-8,048,000	-1,522,000	7,657,000	-10,372,000	-1,799,000	-1,452,000	3,178,000	-2,940,000	1,163,000	-562,000	4,590,000	-7,126,000	374,000	-2,178,000	2,457,000	-1,891,927	-1,484,371	-985,823	1,821,121
inventories	5,194,000	2,457,000	9,601,000	595,000	10,372,000	-8,314,000	3,157,000	-13,339,000	3,231,000	-16,029,000	-19,916,000	-5,390,000	-16,710,000	-8,389,000	-11,963,000	-3,024,000	1,035,000	119,000	-3,084,000	6,691,000	-8,871,000	-2,086,000	-11,095,000	-8,985,000	-13,536,000	-4,764,000	-3,690,000
prepaid and other current assets	-9,792,000	-84,000	-2,264,000	-2,138,000	1,355,000	-678,000	-4,104,000	-1,843,000	-4,149,000	2,061,000	-5,208,000	-1,422,000	-160,000	783,000	741,000	-1,413,000	-568,000	1,823,000	-1,412,000	-1,345,000	1,019,000	130,000	-2,231,000	-567,000	2,516,000	-1,497,000	-1,036,000	-753,000	-2,000	-76,000	-745,000	698,000	-401,000	2,002,000	-468,000	-1,058,000	-243,000	-593,000	-572,000	315,000	-461,000	-193,000	-56,000	-473,774	1,195,816	-686,371	-117,671
other long-term assets	61,000	2,806,000	718,000	453,000	347,000	329,000	-236,000	-1,971,000	443,000	-1,273,000	-386,000	-247,000	-59,000	-319,000	-582,000	1,467,000	5,000	-142,000	-17,000	96,000	27,000	389,000	-383,000	-193,000	28,000	-190,000	-225,000	13,000	4,000	-25,000	-18,000	57,000	-33,000	23,000	-43,000	6,000	7,000	-13,000	-2,000		145,000
accounts payable and accrued expenses	-9,330,000	-898,000	6,637,000	-1,440,000	-1,193,000	3,610,000	-3,369,000		-10,131,000	6,476,000	-919,000						-1,103,000
employee-related liabilities	12,846,000	1,059,000	-13,708,000	5,559,000	15,762,000	1,192,000	-1,654,000	-404,000	8,282,000	-2,501,000	-210,000	-9,284,000	12,541,000	-2,827,000	-13,299,000	4,338,000	10,743,000	3,766,000	-1,448,000	3,635,000	4,798,000	3,159,000	-6,253,000	112,000	4,313,000	6,842,000	-6,982,000	6,801,000	3,589,000	3,130,000	-3,978,000	3,076,000	-1,709,000	1,059,000	1,447,000	-353,000	-416,000	1,414,000	-2,223,000	1,907,000	1,177,000	-112,000	-933,000	1,354,294	2,869,902	-1,077,122	698,926
deferred revenue	-1,392,000	-1,114,000	-1,596,000	-31,147,000	-2,328,000	-889,000	-372,000	11,483,000	7,096,000	2,021,000	925,000	3,360,000	2,064,000	1,644,000	1,290,000	2,837,000	2,486,000	3,417,000	1,871,000	2,814,000	1,547,000	1,144,000	1,524,000	1,002,000	1,048,000	1,678,000	861,000	896,000	739,000	90,000	349,000	231,000	-2,787,000	73,000	-1,423,000	-3,918,000	8,586,000	83,000	-141,000	-130,000	913,000	235,000	-37,000	202,280	123,834	131,421	-28,535
operating leases and other current liabilities	614,000	3,405,000	4,998,000	10,699,000	2,931,000	3,084,000	883,000	-6,443,000	5,722,000	2,128,000	2,895,000	1,140,000			-1,106,000
other long-term liabilities	226,000	4,207,000	644,000	634,000	-547,000	78,000	833,000	7,550,000	-836,000	1,150,000	-114,000	890,000	1,126,000	307,000	-391,000	-1,159,000	373,000	2,579,000	-372,000	1,507,000	1,703,000	2,382,000	-1,704,000	2,214,000	1,213,000	2,541,000	1,444,000	1,334,000	430,000	238,000	365,000	356,000	-207,000	-277,000	-262,000	748,000	7,000	111,000	24,000		1,000
net cash from operating activities	8,264,000	-9,496,000	-18,278,000	10,717,000	26,779,000	-5,275,000	-7,996,000	-7,216,000	55,000	-6,323,000	-18,326,000	5,820,000	23,943,000	6,901,000	13,800,000	19,635,000				15,237,000	14,564,000	15,499,000	-20,631,000	19,442,000	23,019,000	3,568,000	-4,124,000	14,133,000	-3,457,000	-6,723,000	-12,272,000	-11,641,000	-19,018,000	-14,665,000	-20,812,000	-13,582,000	-18,154,000	-13,492,000	-15,945,000	-10,246,000	-14,338,000	-18,758,000	-15,422,000	-15,137,160	-13,580,247	-15,700,636	-16,959,957
capex	-4,092,000	-9,328,000	1,230,000	-5,199,000	-4,103,000	-8,175,000	-1,243,000	-5,477,000	-5,400,000	-8,421,000	-4,757,000	-5,709,000	-10,646,000	-12,415,000	-1,090,000	-5,746,000				-4,096,000	-6,760,000	-9,786,000	-6,766,000	-6,749,000	0	-6,761,000	-1,408,000	-888,000	-1,011,000	-573,000	-514,000	-1,419,000	-244,000	-1,412,000	-2,643,000	-2,743,000	-2,139,000	-2,103,000	-1,945,000	0	-1,743,000	-1,751,000	-600,000	853,831	-969,374	-2,670,593	-1,619,864
free cash flows	4,172,000	-18,824,000	-17,048,000	5,518,000	22,676,000	-13,450,000	-9,239,000	-12,693,000	-5,345,000	-14,744,000	-23,083,000	111,000	13,297,000	-5,514,000	12,710,000	13,889,000				11,141,000	7,804,000	5,713,000	-27,397,000	12,693,000	23,019,000	-3,193,000	-5,532,000	13,245,000	-4,468,000	-7,296,000	-12,786,000	-13,060,000	-19,262,000	-16,077,000	-23,455,000	-16,325,000	-20,293,000	-15,595,000	-17,890,000	-10,246,000	-16,081,000	-20,509,000	-16,022,000	-14,283,329	-14,549,621	-18,371,229	-18,579,821
investing activities
purchases of short-term investments	-29,508,000	-17,046,000	-9,450,000	-12,950,000	-73,637,000	-93,475,000	-84,249,000	-119,834,000	-155,500,000	-126,410,000	-109,115,000	-105,158,000	-132,775,000	-119,000,000	-110,719,000	-190,550,000	-157,258,000	-231,280,000	-154,300,000	-165,108,000	-164,984,000	-157,257,000	-9,727,000	-38,265,000	-52,143,000
proceeds from maturities and redemptions of short-term investments	54,136,000	81,382,000	65,065,000	67,433,000	58,980,000	96,401,000	83,650,000	130,733,000	112,375,000	140,000,000	163,110,000
purchases of property and equipment	-4,092,000	-6,206,000	-2,965,000	-3,069,000	-5,239,000	-6,466,000	-4,457,000	-5,199,000	-5,400,000	-7,377,000	-8,828,000	-5,627,000	-13,710,000	-12,117,000	-2,643,000	-5,746,000	-3,095,000	-1,815,000	-3,524,000	-4,096,000	-6,760,000	-9,786,000	-6,766,000	-6,749,000
acquisition of in-process research and development	0	0	-43,464,000
net cash from investing activities	20,536,000	58,130,000	9,186,000	5,010,000	-19,896,000	-3,540,000	-5,056,000	-16,584,000	-48,525,000	5,698,000	-26,329,000	35,777,000	-14,163,000	6,357,000	5,197,000	-76,818,000	-39,203,000	-64,761,000	-6,094,000	-59,626,000	-137,825,000	-131,521,000	32,916,000	-20,901,000	-22,171,000	-14,661,000	778,000	-6,591,000	-46,811,000	-27,823,000	-9,514,000	-1,419,000	-244,000	1,838,000	2,607,000	4,575,000	5,828,000	1,681,000	-1,636,000	8,860,000	11,529,000	305,000	-18,273,000	9,109,015	-15,146,491	1,193,605	-30,626,129
financing activities
proceeds from issuance of convertible senior notes due 2029, net of 9,400 debt issuance costs				0	0	0	306,850,000
repurchase of 246,740 principal amount of convertible senior notes due 2025				0	0	0	-246,123,000
principal payments on convertible senior notes due 2025	0
payment for capped call transactions related to convertible senior notes due 2029				0	0	0	-15,813,000
repurchase and retirement of common stock				0	0	0	-30,000,000
cash used to settle withholding taxes on vested restricted stock, net of proceeds from issuance of common stock under company stock plans	-1,570,000	1,047,000	-4,688,000
other financing activities				0	0	0	183,000	0				0	-405,000
net cash from financing activities	-1,570,000	-39,713,000	-4,688,000	2,302,000	-4,519,000	-3,002,000	13,586,000	2,617,000	-1,911,000	3,948,000	-541,000	6,100,000	-774,000	8,051,000	3,500,000	15,886,000	18,850,000	13,623,000	3,573,000	9,204,000	29,931,000	263,822,000	11,481,000	6,418,000	7,034,000	8,793,000	1,962,000	1,957,000	22,047,000	22,511,000	70,669,000	14,681,000	3,990,000	-156,000	13,861,000	35,729,000	32,000	1,451,000	15,103,000	1,269,000	93,000	1,825,000	65,068,000	1,646,209	76,967	1,889,075	26,749
effect of foreign exchange rate changes on cash	605,000	1,617,000	-1,880,000	2,166,000	-1,022,000	535,000	-423,000	440,000	-759,000	-334,000	441,000	1,034,000	-186,000	-24,000	3,000	103,000	6,000	30,000	14,000	317,000	332,000	194,000	-456,000	155,000	21,000
net increase in cash and cash equivalents	27,835,000	10,538,000	-15,660,000	20,195,000	1,342,000	-11,282,000	111,000	-20,743,000	-51,140,000	2,989,000	-44,755,000	48,731,000	8,820,000	21,285,000	22,500,000	-41,194,000	13,797,000	-22,213,000	26,178,000	-34,868,000	-92,998,000	147,994,000	23,310,000													26,722,000	-12,294,000	-10,360,000	-2,478,000	-117,000	-2,716,000	-16,628,000	31,373,000			-12,617,956	-47,559,337
cash and cash equivalents at beginning of period	0	0	69,234,000	0	0	0	58,868,000	0	0	0	172,517,000	0	0	0	71,181,000	0	0	0	94,613,000		0	0	51,175,000									0	0	0	44,678,000	0	0	0	43,088,000	0	0	0	31,176,000	-137	0	0	124,385,137
cash and cash equivalents at end of period	27,835,000	10,538,000	53,574,000	20,195,000	1,342,000	-11,282,000	58,979,000	-20,743,000	-51,140,000	2,989,000	127,762,000	48,731,000	8,820,000	21,285,000	93,681,000	-41,194,000	13,797,000	-22,213,000	120,791,000	-34,868,000	-92,998,000	147,994,000	74,485,000									1,621,000	-15,272,000	-12,983,000	40,334,000	26,722,000	-12,294,000	-10,360,000	40,610,000	-117,000	-2,716,000	-16,628,000	62,549,000	-4,382,073	-28,649,771	-12,617,956	76,825,800
supplemental disclosures of cash flow information
income taxes paid	47,000	3,333,000	1,559,000	1,800,000	115,000	914,000	269,000	152,000	0	1,402,000	369,000	249,000	0	-8,000	170,000	0	63,000	0	197,000	-15,000	61,000	40,000	91,000																				18,000
supplemental schedule of non-cash investing and financing activities
operating lease right-of-use assets obtained in exchange for operating lease obligations			1,820,000	-289,000	876,000	1,489,000	2,294,000					3,023,000	465,000
purchases of property and equipment included in accounts payable and accrued expenses
intangible costs in other long term-liabilities	0
accretion (amortization) of discount or premium on short-term investments		-632,000	-1,148,000	-1,726,000			-434,000
purchases of property and equipment included in accounts payable		-3,122,000	4,195,000	-2,130,000	1,136,000	-1,709,000	3,214,000	-278,000
operating lease termination and other impairment charges				0	0
losses from equity method investee
accrued expenses																			278,000	-1,577,000	1,776,000	-1,331,000	-2,124,000	31,000
acquisitions, including in-process research and development, net of cash acquired								0
purchases of equity investments, strategic investments, and intangible assets
proceeds from issuance of common stock under company stock plans, net of cash used to settle withholding taxes on vested restricted stock				2,302,000	-4,519,000	-3,002,000	-1,511,000
interest paid												2,157,000																4,964,000	1,057,000	2,405,000	2,379,000	2,005,000	1,989,000	1,956,000	1,926,000	1,196,000	1,106,000	1,090,000	1,009,000	729,000	881,000	872,000	863,000	568,583	881,667	2,968,750	-1,050,000
purchases of intangible assets and strategic investments								-22,284,000	0
accretion of discount or premium on short-term investments
intangible costs in accounts payable
operating lease termination and impairment charges
amortization of premium on short-term investments								410,000	1,422,000	1,443,000	312,000				562,000
accounts payable																			10,537,000	-2,150,000	3,592,000	-4,618,000	4,294,000	1,779,000	4,925,000	-2,170,000	4,376,000	558,000	2,816,000	-79,000	-1,654,000	-2,475,000	969,000	2,278,000	-2,725,000	2,943,000	-1,440,000	711,000	1,020,000	1,131,000	836,000	34,000	1,354,000	-1,840,963	539,188	557,820	-481,045
proceeds from issuance of common stock under company stock plans								2,617,000	-1,840,000			6,100,000	-369,000	8,254,000	3,484,000	15,887,000	18,695,000	13,623,000	3,135,000	9,189,000	29,032,000	17,171,000	11,474,000	6,418,000	7,033,000	8,531,000	1,898,000
proceeds from exercise of common stock warrants												0	0	67,000	16,000	-1,000	155,000	0	438,000	15,000	899,000	2,029,000	7,000	0	1,000	262,000	64,000
benefit from inventory obsolescence									196,000	22,000	114,000		134,000	295,000	346,000
operating lease impairment charge									0
acquisition, including in-process research and development, net of cash acquired										0	-69,496,000	-23,000
purchase of property and equipment included in accounts payable										-1,044,000	4,071,000	-82,000	3,064,000	-298,000	1,553,000
intangible costs in accounts payable and other long-term liabilities											515,000	0	0	-514,000	1,029,000				2,244,000	-104,000	0
purchase of strategic investment											-2,000,000
proceeds (payments of tax withholdings) related to issuance of common stock under company stock plans											-541,000
amortization of debt discount and issuance costs																435,000	433,000
lease termination and impairment charges
change in fair value of common stock warrants												-44,000	-12,000	-57,000	-34,000	32,000	392,000	272,000	690,000	-2,819,000	3,648,000	14,336,000	1,922,000	226,000	-2,321,000	424,000	12,746,000	-2,548,000	12,265,000	42,549,000	14,228,000
amortization of premium (discount) on short-term investments												806,000	1,582,000						209,000					-263,000	-136,000	-72,000	-94,000	-244,000							-13,000				17,000
benefit for deferred income taxes																				0	0
proceeds from issuance of convertible senior notes, net of 8,809 debt issuance costs																				0	0
payment for capped call transactions related to convertible senior notes
proceeds from maturities of short-term investments													162,200,000	127,303,000	111,559,000	118,478,000	118,650,000	168,407,000	140,200,000	98,213,000	28,000,000	23,850,000	30,859,000	18,413,000
proceeds from sales of short-term investments													4,159,000	10,686,000	7,000,000	1,000,000	2,500,000	9,258,000	11,530,000	11,365,000	6,000,000	16,477,000	18,550,000	5,700,000
acquisition of intangible assets and strategic investments
accounts payable & accrued expenses														6,461,000	13,732,000
operating leases & other current liabilities
acquisition of intangible assets and equity investments																0	0
right-of-use assets obtained in exchange for operating lease obligations															107,478,000	104,000	0	0	15,087,000	0	2,217,000	0	8,805,000	190,000	0	8,392,000	3,053,000
provision (recovery) for inventory obsolescence																			64,000	52,000	-28,000
property and equipment included in accounts payable																89,000	493,000	-472,000	924,000	-536,000	641,000	-903,000	1,880,000	-350,000	2,245,000	109,000	130,000		-35,000	-125,000	217,000		12,000	-169,000	229,000		207,000	154,000	441,000		-876,000	-128,000	1,638,000	743,090	-13,286	-90,283	149,479
benefit from (recovery of) inventory obsolescence																	68,000
amortization of discount on short-term investments																	223,000				-319,000	-1,061,000	-66,000							239,000	59,000		0				-40,000
other current liabilities																	2,391,000	76,000	1,094,000	766,000	2,595,000	1,997,000	431,000	1,881,000	3,385,000	1,070,000	-2,120,000	2,119,000	1,149,000	307,000	-356,000	861,000	249,000	-468,000	-382,000	-775,000	945,000	542,000	-139,000	1,729,000	242,000	113,000	-160,000	247,330	-579,840	34,830	-1,277,320
intangible costs in other current and other long-term liabilities																	0
adjustments to reconcile net income to net cash provided (used) by operating activities:
net cash provided (used) by operating activities																		28,895,000	28,685,000
amortization of debt discount and debt issuance costs																				3,863,000	3,776,000
acquisition of intangible assets																				0	-81,000
purchase of capped call options related to convertible senior notes																				0	0
principal payments on notes payable																												0																0	0
proceeds from public offerings, net of offering costs
cash and cash equivalents and restricted cash at beginning of period																								0	0	0	41,826,000	0	0	0	23,700,000
benefit for inventory obsolescence																							-363,000
interest expense related to amortization of debt discount and debt issuance costs																												0	334,000	695,000	692,000	545,000	521,000	523,000	294,000	80,000	52,000	64,000	78,000	29,000	38,000	36,000	35,000	43,192	42,104	40,827	92,877
payment in kind interest accrual of notes payable																																421,000	419,000	412,000	405,000	252,000	235,000	228,000	212,000
benefit from allowance for doubtful accounts																								854,000	671,000	455,000	342,000	431,000	272,000	386,000	359,000	160,000	247,000	110,000	307,000	-34,000	65,000	229,000	372,000	78,000	92,000	-69,000	-31,000	83,274	3,760	46,615	54,351
benefit from inventories reserve																								845,000	490,000	339,000	679,000
net increase in cash and cash equivalents and restricted cash																								5,114,000	7,903,000	-2,285,000	-1,384,000	9,499,000	-28,221,000	-12,035,000	48,883,000
cash and cash equivalents and restricted cash at end of period																										-2,288,000	40,445,000	9,499,000	-28,221,000	-12,035,000	72,583,000
lease incentive - lessor-paid tenant improvements																																255,000	253,000	1,011,000	1,773,000
debt discount included in other long-term liabilities																														4,137,000	827,000	21,000	21,000	1,536,000	2,559,000
common stock warrants issued in connection with term loan																																0	0	0	3,331,000
unsettled purchase of investments classified as cash equivalents in other current liabilities
deferred rent																												-214,000	-212,000	-174,000	-185,000	-267,000	-159,000	-104,000	-162,000	567,000	-113,000	-243,000	-210,000	-162,000	-161,000	-157,000	-151,000	-1,750,451	-149,382	1,506,119	-67,286
proceeds from public offering, net of offering costs																												0	108,921,000	-149,000	64,157,000	14,681,000	3,990,000	-460,000	21,595,000					0	0	11,000	64,851,000
accrued expense																										2,404,000	-553,000	-1,000	-348,000	1,080,000	366,000	296,000	1,780,000	-1,728,000	855,000		-222,000	42,000	36,000		673,000	-673,000	-260,000	1,656,082	-495,943	197,745	-384,884
proceeds from maturities and sales of short-term investments
purchase of property and equipment																										-6,761,000	-1,408,000	-888,000	-1,011,000	-573,000	-514,000	-1,419,000	-244,000	-1,412,000	-2,643,000	-2,743,000	-2,139,000	-2,103,000	-1,945,000		-1,743,000	-1,751,000	-600,000	853,831	-969,374	-2,670,593	-1,619,864
supplemental schedule of noncash investing and financing activities
purchase of short-term investments																											-42,914,000		-60,050,000	-31,500,000	-9,000,000					-4,732,000	-3,233,000	-9,216,000	-13,441,000	-12,720,000	-8,478,000	-19,894,000	-39,099,000	-5,245,016	-26,027,117	-6,995,802	-28,833,065
proceeds from sales and maturities of short-term investments																											45,100,000	17,300,000	14,250,000			0	0	3,250,000	5,250,000	12,050,000	11,200,000	13,000,000	13,750,000	23,250,000	21,750,000	21,950,000	21,500,000	13,500,000	11,850,000
effect of foreign exchange rates on cash																											3,000
public offering costs included in accounts payable																															129,000				374,000
benefit from inventory reserve																												210,000	213,000	77,000	107,000	-290,000	51,000	134,000	131,000	1,538,000				87,000	216,000			-246	0	-96,858	260,104
inventory																												4,004,000	794,000	1,616,000	342,000	3,144,000	-4,241,000	-2,182,000	-2,615,000	206,000	-3,002,000	-1,486,000	-2,622,000	-97,000	-3,095,000	-1,234,000	-1,658,000	-47,662	-764,582	-819,671	-188,085
issuance of notes payable, net of issuance costs																																				35,000,000	0	0	14,994,000					0	0
property and equipment included in accounts payable & other current liabilities
proceeds from exercise of warrants																													372,000	22,652,000	6,512,000
proceeds from common stock issued under employee benefit plans																													465,000
proceeds from exercise of common stock
amortization of (discount) premium on short-term investments
purchase of patents																																								0	0	0	-74,000	200	0	0	-173,200
restricted cash in connection with notes payable																																0	0	0	-8,000,000
proceeds from issuance of common stock																																0	0	304,000	266,000	729,000	32,000	1,451,000	109,000	1,269,000	93,000	1,814,000	217,000	1,646,209	76,967
net decrease in cash and cash equivalents																																	-15,272,000	-12,983,000	-4,344,000
restricted cash in connection with notes payable and corporate credit card																																												0	0
patent included in accrued expense
debt issuance cost included in other long-term liabilities																																					0	2,000	452,000
gain on disposal of property and equipment
change in fair value of common and preferred stock warrants
amortization of premium/discount on short-term investments																																								25,000	16,000	-19,000	-18,000	-20,287
other long term assets																																											-17,000
other long term liabilities																																											366,000		268,195	133,193	-66,905
purchase of property and equipment, net of gain on sale of property and equipment
proceeds from issuance of preferred stock for cash, net of offering costs
common and preferred stock warrants issued, including incremental value of modification of warrants
conversion of preferred stock warrants into common stock warrants
conversion of convertible preferred stock into common stock
lease incentive—lessor-paid tenant improvements																																									0
accretion of discount on notes payable and convertible notes
payments received on note receivable from employees
issuance of convertible notes payable
proceeds from initial public offering, net of offering costs
conversion of notes payable and accrued interest for series d convertible preferred stock
restricted cash
issuance of preferred stock for cash, net of offering costs
deferred initial public offering costs
unrealized gain on short-term investments																																													6,529	-1,551	13,833
deferred initial public offering costs included in accounts payable
loss on disposal of property and equipment
amortization of discount on short-term investment																																															-5,714
proceeds from issuance of common stock for cash and exercise of common stock options																																															26,749
taxes paid																																															-87,853
common warrants issued
repayment of note receivable from officer

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