Theravance Biopharma, Inc(NASDAQ:TBPH)
Theravance Biopharma, Inc., a diversified biopharmaceutical company, discovers, develops, and commercializes organ-selective medicines in the United States, Europe, and Asia. The company offers YUPELRI, a once-daily, nebulized long-acting muscarinic antagonist used for the treatment of chronic obstr...
Website: http://www.theravance.com
Founded: 2013
Full Time Employees: 316
Sector: Healthcare
Industry: Biotechnology
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At a glance:
Bull Thesis:
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Quarterly
Annual
| Unit: USD | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 |
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revenues: | |||||||||||||||||||||||||||||||||||||||||||||
viatris collaboration agreement | 17,699,000 | 20,891,000 | 19,990,000 | 18,695,000 | 15,388,000 | 18,754,000 | 16,868,000 | 14,256,000 | 14,503,000 | 17,360,000 | 15,687,000 | 13,743,000 | 10,411,000 | 14,614,000 | 12,445,000 | 10,878,000 | 10,687,000 | 12,132,000 | 10,397,000 | 10,934,000 | 10,385,000 | ||||||||||||||||||||||||
total revenues | 17,699,000 | 45,891,000 | 19,990,000 | 26,195,000 | 15,388,000 | 18,754,000 | 16,868,000 | ||||||||||||||||||||||||||||||||||||||
yoy | 15.02% | 144.70% | 18.51% | ||||||||||||||||||||||||||||||||||||||||||
qoq | -61.43% | 129.57% | -23.69% | 70.23% | -17.95% | 11.18% | |||||||||||||||||||||||||||||||||||||||
expenses: | |||||||||||||||||||||||||||||||||||||||||||||
research and development | 5,829,000 | 7,360,000 | 8,112,000 | 10,490,000 | 11,452,000 | 9,453,000 | 9,268,000 | 9,954,000 | 8,968,000 | 8,313,000 | 8,311,000 | 9,425,000 | 14,572,000 | 14,701,000 | 9,867,000 | 15,571,000 | 23,253,000 | 31,226,000 | 43,739,000 | 51,093,000 | 67,599,000 | 65,165,000 | 67,371,000 | 62,404,000 | 66,013,000 | 67,025,000 | 52,006,000 | 46,399,000 | 53,818,000 | 52,269,000 | 52,693,000 | 48,621,000 | 47,765,000 | 39,343,000 | 42,927,000 | 40,565,000 | 31,951,000 | 32,069,000 | 35,678,000 | 30,367,000 | 30,377,000 | 36,019,000 | 38,324,000 | 46,283,000 | 41,723,000 |
selling, general and administrative | 17,720,000 | 18,520,000 | 18,333,000 | 18,430,000 | 18,370,000 | 18,501,000 | 16,875,000 | 17,056,000 | 16,742,000 | 15,492,000 | 16,142,000 | 19,278,000 | 19,183,000 | 15,968,000 | 16,277,000 | 16,986,000 | 19,121,000 | 21,516,000 | 21,299,000 | 25,931,000 | 30,550,000 | 30,055,000 | 27,501,000 | 24,780,000 | 26,325,000 | 33,046,000 | 25,622,000 | 22,227,000 | 25,186,000 | 25,457,000 | 21,890,000 | 25,007,000 | 24,704,000 | 20,944,000 | 24,339,000 | 20,786,000 | 20,286,000 | 20,261,000 | 23,596,000 | 22,845,000 | 21,545,000 | 21,748,000 | 17,705,000 | 13,118,000 | 19,052,000 |
restructuring expenses | 3,633,000 | ||||||||||||||||||||||||||||||||||||||||||||
total expenses | 27,182,000 | 25,880,000 | 26,445,000 | 28,920,000 | 29,822,000 | 27,954,000 | 27,705,000 | 29,961,000 | 25,710,000 | 23,805,000 | 24,453,000 | 29,872,000 | 35,329,000 | 32,080,000 | 26,653,000 | 37,929,000 | 51,698,000 | 71,113,000 | 66,809,000 | ||||||||||||||||||||||||||
income from operations | -9,483,000 | 20,011,000 | -6,455,000 | -2,725,000 | -14,434,000 | -9,200,000 | -10,837,000 | -15,705,000 | -11,207,000 | -6,240,000 | -8,760,000 | -16,123,000 | -24,912,000 | -17,431,000 | -14,202,000 | -26,879,000 | -38,502,000 | -56,167,000 | -53,615,000 | -64,110,000 | -83,892,000 | -76,490,000 | -76,615,000 | -72,176,000 | -72,476,000 | -70,572,000 | -65,201,000 | -42,476,000 | -73,666,000 | -62,621,000 | -62,450,000 | -48,704,000 | -64,976,000 | ||||||||||||
yoy | -34.30% | -317.51% | -40.44% | -82.65% | 28.79% | 47.44% | 23.71% | -2.59% | -55.01% | -64.20% | -38.32% | -40.02% | -35.30% | -68.97% | -73.51% | -58.07% | -54.11% | -26.57% | -30.02% | -11.18% | 15.75% | 8.39% | 17.51% | 69.92% | -1.62% | 12.70% | 4.41% | -12.79% | 13.37% | ||||||||||||||||
qoq | -147.39% | -410.01% | 136.88% | -81.12% | 56.89% | -15.11% | -31.00% | 40.14% | 79.60% | -28.77% | -45.67% | -35.28% | 42.92% | 22.74% | -47.16% | -30.19% | -31.45% | 4.76% | -16.37% | -23.58% | 9.68% | -0.16% | 6.15% | -0.41% | 2.70% | 8.24% | 53.50% | -42.34% | 17.64% | 0.27% | 28.22% | -25.04% | |||||||||||||
operating margin % | -53.58% | 43.61% | -32.29% | -10.40% | -93.80% | -49.06% | -64.25% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% |
interest expense | -582,000 | -573,000 | -663,000 | -643,000 | -643,000 | -630,000 | -644,000 | -629,000 | -623,000 | -609,000 | -568,000 | -550,000 | -550,000 | -1,545,000 | -11,884,000 | -11,655,000 | -11,662,000 | -11,742,000 | -11,612,000 | -11,873,000 | -11,680,000 | -11,573,000 | -11,391,000 | -9,941,000 | -8,035,000 | -8,068,000 | -7,901,000 | -7,858,000 | -4,071,000 | -2,137,000 | -2,137,000 | -2,137,000 | |||||||||||||
interest and other income | 3,013,000 | 3,639,000 | 4,139,000 | 1,457,000 | 939,000 | 904,000 | 1,415,000 | 338,000 | -166,000 | 1,171,000 | -234,000 | 798,000 | 1,235,000 | -662,000 | 1,460,000 | 1,137,000 | 2,089,000 | 2,374,000 | 2,795,000 | 7,822,000 | 1,376,000 | 1,284,000 | 2,170,000 | 1,124,000 | 1,425,000 | 1,030,000 | 344,000 | 308,000 | 186,000 | 104,000 | 204,000 | 211,000 | |||||||||||||
income before income taxes | -6,470,000 | 73,068,000 | -2,889,000 | 73,206,000 | -14,138,000 | -8,939,000 | -10,052,000 | -15,221,000 | -10,402,000 | -8,196,000 | -25,422,000 | -32,185,000 | -35,315,000 | -52,625,000 | -79,452,000 | -67,233,000 | -73,550,000 | -62,848,000 | -82,906,000 | -65,557,000 | -63,983,000 | -39,637,000 | -72,500,000 | -53,442,000 | -60,092,000 | -47,608,000 | -64,943,000 | ||||||||||||||||||
provision for income tax benefit | 1,537,000 | -2,827,000 | 6,504,000 | 559,000 | -1,458,000 | 395,000 | 3,000 | 5,000 | 7,000 | 220,000 | 8,799,000 | -93,000 | -49,000 | 5,552,000 | -201,000 | ||||||||||||||||||||||||||||||
net income | -4,933,000 | 61,024,000 | 3,615,000 | 54,835,000 | -13,579,000 | -15,527,000 | -12,698,000 | -16,529,000 | -11,664,000 | -8,510,000 | -8,950,000 | -15,645,000 | -22,088,000 | -10,362,000 | 916,631,000 | -8,191,000 | -25,946,000 | -32,034,000 | -35,308,000 | -52,405,000 | -79,679,000 | -58,434,000 | -73,643,000 | -62,887,000 | -83,053,000 | -65,606,000 | -58,431,000 | -39,838,000 | -72,580,000 | -50,186,000 | -59,433,000 | -40,818,000 | -65,087,000 | -66,877,000 | -66,287,000 | -65,319,000 | -33,962,000 | -47,225,000 | -42,150,000 | -47,314,000 | -47,603,000 | -42,474,000 | -54,495,000 | -58,215,000 | |
yoy | -63.67% | -493.02% | -128.47% | -431.75% | 16.42% | 82.46% | 41.88% | 5.65% | -47.19% | -17.87% | -100.98% | 91.00% | -14.87% | -67.65% | -2696.10% | -84.37% | -67.44% | -45.18% | -52.06% | -16.67% | -4.06% | -10.93% | 26.03% | 57.86% | 14.43% | 30.73% | -1.69% | -2.40% | 11.51% | -24.96% | -10.34% | -37.51% | 91.65% | 41.61% | 57.26% | 38.05% | -28.66% | 11.19% | -22.65% | -18.73% | |||||
qoq | -108.08% | 1588.08% | -93.41% | -503.82% | -12.55% | 22.28% | -23.18% | 41.71% | 37.06% | -4.92% | -42.79% | -29.17% | 113.16% | -101.13% | -11290.71% | -68.43% | -19.00% | -9.27% | -32.62% | -34.23% | 36.36% | -20.65% | 17.10% | -24.28% | 26.59% | 12.28% | 46.67% | -45.11% | 44.62% | -15.56% | 45.60% | -37.29% | -2.68% | 0.89% | 1.48% | 92.33% | -28.08% | 12.04% | -10.91% | -0.61% | 12.08% | -22.06% | -6.39% | ||
net income margin % | -27.87% | 132.98% | 18.08% | 209.33% | -88.24% | -82.79% | -75.28% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | NaN% |
net unrealized loss on available-for-sale investments | -123,000 | -337,000 | -17,000 | -28,000 | -120 | ||||||||||||||||||||||||||||||||||||||||
total comprehensive loss | -5,056,000 | -13,586,000 | -10,194,000 | -12,626,000 | -16,510,000 | -11,640,000 | -15,982,000 | -22,022,000 | -8,208,000 | -25,974,000 | -41,856,250 | -35,302,000 | -52,414,000 | -79,709,000 | -54,901,500 | -73,801,000 | -63,119,000 | -82,686,000 | -42,647,250 | -58,466,000 | -39,673,000 | -72,450,000 | -41,234 | -59,239 | -40,489 | -65,207 | -66,921 | -66,263 | -65,338 | -34,104 | -47,170 | -41,954 | -47,295 | ||||||||||||
net income per share | -0.1 | 1.21 | 0.07 | 1.09 | |||||||||||||||||||||||||||||||||||||||||
shares used to compute net loss per share - basic and diluted | 51,279 | ||||||||||||||||||||||||||||||||||||||||||||
licensing revenue | 1,875,000 | 7,500,000 | 2,500,000 | 1,500,000 | 10,000,000 | 18,500,000 | |||||||||||||||||||||||||||||||||||||||
impairment of long-lived assets | 1,562,000 | 2,951,000 | |||||||||||||||||||||||||||||||||||||||||||
net gain on realized contingent milestone and royalty assets | 75,137,000 | ||||||||||||||||||||||||||||||||||||||||||||
net unrealized gain on available-for-sale investments | 6,250 | 42,000 | -10,000 | -7,000 | 28,750 | 72,000 | 19,000 | 24,000 | -52,500 | 61,000 | 66,000 | -30,250 | -76,000 | -8,250 | 6,000 | -9,000 | -30,000 | -5,750 | -158,000 | -232,000 | 367,000 | 65,000 | -35,000 | 165,000 | 130,000 | 100.5 | 194 | 329 | 24 | 55 | 196 | 19 | |||||||||||||
total comprehensive income | 11,224,000 | 3,657,000 | 54,825,000 | -11,723,250 | -8,889,000 | 220,593,250 | 916,555,000 | ||||||||||||||||||||||||||||||||||||||
shares used to compute net income per share - basic | 180 | 50,520 | 50,177 | ||||||||||||||||||||||||||||||||||||||||||
shares used to compute net income per share - diluted | 531 | 51,908 | 50,726 | ||||||||||||||||||||||||||||||||||||||||||
provision for income tax expense | -18,371,000 | -6,588,000 | -2,646,000 | -1,308,000 | 1,262,000 | -3,494,000 | -1,367,000 | 3,894,000 | -182,362,000 | -524,000 | -227,000 | -39,000 | -147,000 | -80,000 | |||||||||||||||||||||||||||||||
basic and diluted net loss per share | -0.27 | -0.31 | -0.26 | -0.34 | -0.24 | -0.11 | -0.34 | -0.41 | -0.48 | -0.8 | -1.24 | -0.91 | -1.16 | -1 | -1.4 | -1.17 | -1.05 | -0.72 | -1.32 | -0.92 | -1.1 | -0.76 | -1.22 | -1.27 | -1.27 | -1.27 | -0.73 | -1.06 | -1.1 | -1.4 | -1.42 | -1.29 | -1.72 | -1.83 | |||||||||||
shares used to compute basic and diluted net loss per share | 49,706 | 157 | 49,038 | 48,747 | 48,283 | 76,270 | 75,247 | 1,516 | 73,574 | 65,669 | 64,493 | 464 | 63,303 | 62,861 | 59,463 | 165 | 55,858 | 55,529 | 54,938 | 198 | 54,248 | 53,799 | 53,256 | 52,611 | 52,255 | 51,617 | 46,470 | 44,407 | 38,326 | 33,689 | 33,532 | 32,830 | 31,754 | 31,768 | |||||||||||
collaboration revenue | 198,000 | 6,000 | 6,000 | 6,000 | 5,000 | 6,000 | 172,000 | 9,000 | 2,814,000 | 2,797,000 | 1,980,000 | 3,872,000 | 7,083,000 | 7,261,000 | 5,488,000 | 6,632,000 | 9,584,000 | 8,836,000 | 7,650,000 | 5,338,000 | |||||||||||||||||||||||||
restructuring and related expenses | 1,169,000 | 1,574,000 | 1,411,000 | 509,000 | 1,594,000 | 9,324,000 | 18,371,000 | 1,771,000 | |||||||||||||||||||||||||||||||||||||
revenue: | |||||||||||||||||||||||||||||||||||||||||||||
total revenue | 14,256,000 | 14,503,000 | 17,565,000 | 15,693,000 | 13,749,000 | 10,417,000 | 14,649,000 | 12,451,000 | 11,050,000 | 13,196,000 | 14,946,000 | 13,194,000 | 12,914,000 | 14,257,000 | 18,730,000 | 18,257,000 | 15,008,000 | 19,862,000 | 29,499,000 | 12,427,000 | 26,150,000 | 5,338,000 | 15,737,000 | 12,838,000 | 23,476,000 | 8,319,000 | 4,275,000 | 3,509,000 | 3,087,000 | 19,075,000 | 5,471,000 | 18,410,000 | 10,698,000 | 7,134,000 | 20,401,000 | 6,336,000 | 2,974,000 | 945,000 | |||||||
interest income and other income | 1,128,000 | 1,434,000 | 1,847,000 | 1,786,000 | 2,504,000 | 2,979,000 | 3,722,000 | 2,758,000 | 2,440,000 | -375,000 | 668,000 | ||||||||||||||||||||||||||||||||||
loss on extinguishment of debt | -3,034,000 | -15,464,000 | |||||||||||||||||||||||||||||||||||||||||||
loss from continuing operations before income taxes | -5,016,000 | -7,583,000 | -14,187,000 | -22,483,000 | -14,259,000 | -16,023,000 | |||||||||||||||||||||||||||||||||||||||
net income from continuing operations | -8,510,000 | -8,950,000 | -15,645,000 | -22,088,000 | -14,256,000 | -16,023,000 | |||||||||||||||||||||||||||||||||||||||
income from discontinued operations before income taxes | 1,115,016,000 | ||||||||||||||||||||||||||||||||||||||||||||
net income from discontinued operations | 3,894,000 | 932,654,000 | |||||||||||||||||||||||||||||||||||||||||||
continuing operations - basic and diluted | -0.19 | -0.17 | -0.28 | -0.35 | -0.22 | -0.21 | |||||||||||||||||||||||||||||||||||||||
discontinued operations - basic and diluted | 0.41 | 12.35 | |||||||||||||||||||||||||||||||||||||||||||
net income - basic and diluted | -0.19 | -0.17 | |||||||||||||||||||||||||||||||||||||||||||
shares used to compute basic and diluted net income per share | -1,984 | 52,361 | 56,682 | ||||||||||||||||||||||||||||||||||||||||||
net loss - basic and diluted | -0.28 | ||||||||||||||||||||||||||||||||||||||||||||
net loss - basis and diluted | -0.35 | ||||||||||||||||||||||||||||||||||||||||||||
shares used to compute basis and diluted net loss per share | 62,934 | ||||||||||||||||||||||||||||||||||||||||||||
net income - basis and diluted | 0.19 | 12.14 | |||||||||||||||||||||||||||||||||||||||||||
shares used to compute basis and diluted net income per share | -2,087 | 75,515 | |||||||||||||||||||||||||||||||||||||||||||
transaction-related legal expenses | 3,778,000 | ||||||||||||||||||||||||||||||||||||||||||||
income from investment in trc, llc | 28,127,000 | 25,110,000 | 35,306,000 | 30,208,000 | 21,926,000 | 16,547,000 | 20,139,000 | 13,403,000 | 21,381,000 | 13,515,000 | 11,913,000 | 7,197,000 | 8,366,000 | 6,229,000 | 5,428,000 | 3,119,000 | 1,949,000 | ||||||||||||||||||||||||||||
costs and expenses: | |||||||||||||||||||||||||||||||||||||||||||||
total costs and expenses | 77,024,000 | 98,149,000 | 95,220,000 | 94,872,000 | 87,184,000 | 92,338,000 | 100,071,000 | 77,628,000 | 68,626,000 | 79,004,000 | 78,358,000 | 75,288,000 | 72,180,000 | 73,295,000 | 61,272,000 | 68,630,000 | 61,916,000 | 52,569,000 | 52,968,000 | 60,052,000 | 53,793,000 | 52,427,000 | 58,138,000 | 56,398,000 | 59,680,000 | 60,963,000 | |||||||||||||||||||
mylan collaboration agreement | 8,061,500 | 10,996,000 | 9,520,000 | 11,730,000 | 9,915,000 | 3,591,000 | |||||||||||||||||||||||||||||||||||||||
product sales | 2,415,000 | 3,849,000 | 5,361,000 | 3,679,000 | 4,140,000 | 3,474,000 | 3,050,000 | 3,901,000 | 5,359,000 | 3,311,000 | 2,312,000 | 2,124,000 | 1,280,000 | 1,303,000 | 861,000 | 945,000 | |||||||||||||||||||||||||||||
cost of goods sold | 632,000 | 705,000 | -1,448,000 | 826,000 | 985,000 | 1,364,000 | 565,000 | 332,000 | 638,000 | 778,000 | 581,000 | 505,000 | 371,000 | 369,000 | 279,000 | 188,000 | |||||||||||||||||||||||||||||
revenue from collaborative arrangements | 7,936,000 | 8,989,000 | 18,115,000 | 4,640,000 | 135,000 | 35,000 | 37,000 | 15,174,000 | 112,000 | 15,099,000 | 8,386,000 | 5,010,000 | 19,121,000 | 5,033,000 | |||||||||||||||||||||||||||||||
other-than-temporary impairment loss | |||||||||||||||||||||||||||||||||||||||||||||
provision for income tax | -1,826,250 | -659,000 | -6,790,000 | ||||||||||||||||||||||||||||||||||||||||||
provision for income taxes | 144,000 | 868,000 | 454,000 | 5,383,000 | 812,000 | 36,000 | 694,000 | 4,323,000 | 2,514,000 | 4,948,000 | |||||||||||||||||||||||||||||||||||
revenue from collaboration agreements | 2,113,000 | ||||||||||||||||||||||||||||||||||||||||||||
other income | 214,000 | ||||||||||||||||||||||||||||||||||||||||||||
net income and comprehensive loss | -60,018,000 |
Balance Sheets:
Quarterly
Annual
| Unit: USD | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-09-30 | 2014-06-30 |
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assets | ||||||||||||||||||||||||||||||||||||||||||||
current assets: | ||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents | 288,101,000 | 167,806,000 | 174,773,000 | 281,927,000 | 110,614,000 | 37,797,000 | 23,378,000 | 46,345,000 | 53,835,000 | 39,545,000 | 71,685,000 | 105,596,000 | 187,665,000 | 298,172,000 | 418,538,000 | 87,292,000 | 94,367,000 | 89,959,000 | 121,424,000 | 204,949,000 | 114,011,000 | 81,467,000 | 93,282,000 | 104,735,000 | 332,798,000 | 58,064,000 | 102,403,000 | 178,311,000 | 223,235,000 | 378,021,000 | 101,202,000 | 103,854,000 | 125,831,000 | 91,301,000 | 139,626,000 | 169,945,000 | 86,572,000 | 148,363,000 | 128,803,000 | 127,114,000 | 97,090,000 | 100,899,000 | 122,228,000 | 268,199,000 |
short-term marketable securities | 106,565,000 | 147,551,000 | 154,907,000 | 56,877,000 | 20,241,000 | 50,553,000 | 67,983,000 | 49,733,000 | 46,140,000 | 62,881,000 | 62,318,000 | 61,855,000 | 53,598,000 | 29,312,000 | 68,294,000 | 45,558,000 | 53,149,000 | 83,506,000 | 94,789,000 | 60,004,000 | 95,957,000 | 211,474,000 | 265,065,000 | 333,605,000 | 154,233,000 | 222,767,000 | 217,278,000 | 217,761,000 | 210,823,000 | 127,255,000 | 199,207,000 | 249,049,000 | 292,700,000 | 243,700,000 | 222,194,000 | 222,823,000 | 143,910,000 | 101,316,000 | 51,073,000 | 68,856,000 | 113,896,000 | 135,337,000 | 162,489,000 | |
receivables from collaborative arrangements | 15,584,000 | 45,539,000 | 18,267,000 | 21,919,000 | 15,353,000 | 18,440,000 | 16,845,000 | 14,299,000 | 14,664,000 | 17,474,000 | 17,057,000 | 15,796,000 | 12,270,000 | 16,785,000 | 14,114,000 | 12,488,000 | 12,277,000 | 14,065,000 | 14,001,000 | 12,220,000 | 11,915,000 | 15,868,000 | 12,399,000 | 11,413,000 | 14,214,000 | 11,996,000 | 4,595,000 | 979,000 | 7,824,000 | 10,053,000 | 3,907,000 | 3,865,000 | 2,845,000 | 11,547,000 | 5,318,000 | 7,639,000 | 22,713,000 | 35,080,000 | 37,536,000 | 19,640,000 | 25,488,000 | 19,660,000 | 181,000 | 2,000 |
receivables from milestones and royalty assets | 50,000,000 | 50,000,000 | ||||||||||||||||||||||||||||||||||||||||||
other prepaid and current assets | 7,384,000 | 7,564,000 | 6,750,000 | 5,571,000 | 4,056,000 | 4,204,000 | 7,677,000 | 6,284,000 | 7,569,000 | 11,603,000 | 8,996,000 | 7,777,000 | 6,281,000 | 7,682,000 | 8,127,000 | 7,080,000 | 4,542,000 | 8,561,000 | 9,943,000 | 12,353,000 | 10,037,000 | 10,359,000 | 10,308,000 | 13,124,000 | 5,491,000 | 7,087,000 | 7,132,000 | 8,857,000 | 24,928,000 | 16,564,000 | 7,029,000 | 7,641,000 | 5,326,000 | 3,462,000 | 4,030,000 | 3,566,000 | 4,319,000 | 3,550,000 | 10,165,000 | |||||
total current assets | 417,634,000 | 418,460,000 | 354,697,000 | 366,294,000 | 150,264,000 | 161,067,000 | 116,480,000 | 119,307,000 | 124,294,000 | 133,541,000 | 161,690,000 | 192,003,000 | 261,338,000 | 353,464,000 | 511,718,000 | 154,729,000 | 204,636,000 | 249,870,000 | 297,172,000 | 333,180,000 | 293,071,000 | 393,341,000 | 450,724,000 | 498,386,000 | 534,218,000 | 338,488,000 | 355,652,000 | 426,038,000 | 467,233,000 | 532,823,000 | 332,606,000 | 386,693,000 | 446,818,000 | 367,133,000 | 384,882,000 | 421,504,000 | 274,035,000 | 303,125,000 | 238,752,000 | 238,239,000 | 260,226,000 | 275,556,000 | 306,711,000 | 382,733,000 |
long-term marketable securities | 11,128,000 | 3,029,000 | 18,776,000 | 5,067,000 | 4,985,000 | 24,939,000 | 11,869,000 | 20,217,000 | 18,252,000 | 16,999,000 | 99,399,000 | 136,445,000 | 147,885,000 | 58,769,000 | 52,316,000 | 34,598,000 | ||||||||||||||||||||||||||||
property and equipment | 5,539,000 | 5,895,000 | 6,257,000 | 6,641,000 | 7,028,000 | 7,418,000 | 7,788,000 | 8,142,000 | 8,717,000 | 9,068,000 | 9,288,000 | 9,553,000 | 12,103,000 | 11,875,000 | 11,884,000 | 12,531,000 | 13,236,000 | 13,657,000 | 16,003,000 | 16,583,000 | 16,944,000 | 16,422,000 | 15,430,000 | 14,433,000 | 13,905,000 | 12,644,000 | 12,189,000 | 12,662,000 | 12,899,000 | 13,176,000 | 12,415,000 | 10,677,000 | 10,329,000 | 8,618,000 | 8,679,000 | 8,251,000 | 8,832,000 | 8,811,000 | 10,119,000 | 9,513,000 | 9,609,000 | 9,305,000 | 9,356,000 | 9,624,000 |
operating lease assets | 23,001,000 | 24,371,000 | 25,450,000 | 26,493,000 | 27,430,000 | 28,354,000 | 29,334,000 | 31,815,000 | 35,364,000 | 36,287,000 | 37,576,000 | 38,453,000 | 39,204,000 | 40,126,000 | 39,992,000 | 41,112,000 | 39,349,000 | 39,690,000 | 40,718,000 | 41,508,000 | 42,517,000 | 43,260,000 | 44,391,000 | 45,184,000 | 46,106,000 | 46,604,000 | 46,755,000 | 47,831,000 | 48,861,000 | |||||||||||||||
restricted cash | 836,000 | 836,000 | 836,000 | 836,000 | 836,000 | 836,000 | 836,000 | 836,000 | 836,000 | 836,000 | 836,000 | 836,000 | 836,000 | 836,000 | 836,000 | 836,000 | 836,000 | 837,000 | 833,000 | 833,000 | 833,000 | 833,000 | 833,000 | 833,000 | 833,000 | 833,000 | 833,000 | 833,000 | 833,000 | 833,000 | 833,000 | 833,000 | 833,000 | 833,000 | 833,000 | 833,000 | 833,000 | 833,000 | 833,000 | 833,000 | 833,000 | 833,000 | ||
other assets | 25,303,000 | 24,880,000 | 25,191,000 | 25,771,000 | 13,824,000 | 12,286,000 | 7,467,000 | 7,729,000 | 7,896,000 | 8,067,000 | 10,000,000 | 11,585,000 | 12,093,000 | 6,899,000 | 4,866,000 | 3,303,000 | 3,194,000 | 3,228,000 | 3,297,000 | 1,325,000 | 2,304,000 | 2,451,000 | 810,000 | 1,508,000 | 1,308,000 | 1,590,000 | 1,305,000 | 1,388,000 | 1,439,000 | 1,534,000 | 1,762,000 | 1,766,000 | 1,805,000 | 2,106,000 | 5,047,000 | 1,566,000 | 5,820,000 | 1,403,000 | 823,000 | 921,000 | 1,017,000 | 686,000 | ||
total assets | 472,313,000 | 485,570,000 | 415,460,000 | 426,035,000 | 343,582,000 | 354,161,000 | 356,105,000 | 362,029,000 | 371,307,000 | 381,999,000 | 413,590,000 | 446,630,000 | 538,550,000 | 607,400,000 | 763,496,000 | 360,761,000 | 355,359,000 | 374,819,000 | 403,109,000 | 429,251,000 | 375,108,000 | 469,057,000 | 512,188,000 | 564,330,000 | 605,409,000 | 408,826,000 | 445,337,000 | 492,447,000 | 531,265,000 | 560,235,000 | 370,964,000 | 421,364,000 | 480,108,000 | 486,159,000 | 543,886,000 | 588,039,000 | 356,289,000 | 374,488,000 | 293,125,000 | 257,506,000 | 289,479,000 | 324,901,000 | 381,705,000 | 430,588,000 |
liabilities and shareholders' equity | ||||||||||||||||||||||||||||||||||||||||||||
current liabilities: | ||||||||||||||||||||||||||||||||||||||||||||
accounts payable | 1,100,000 | 2,568,000 | 2,213,000 | 1,675,000 | 2,408,000 | 2,242,000 | 1,454,000 | 1,674,000 | 1,686,000 | 1,524,000 | 2,368,000 | 1,569,000 | 2,663,000 | 1,554,000 | 5,337,000 | 3,074,000 | 1,510,000 | 3,098,000 | 8,900,000 | 10,702,000 | 6,834,000 | 6,775,000 | 6,442,000 | 10,065,000 | 6,645,000 | 4,758,000 | 8,713,000 | 3,501,000 | 5,596,000 | 9,028,000 | 3,745,000 | 3,644,000 | 5,085,000 | 5,623,000 | 6,406,000 | 3,626,000 | 5,351,000 | 7,412,000 | 9,092,000 | 5,963,000 | 6,335,000 | 4,021,000 | 5,284,000 | 9,499,000 |
accrued personnel-related expenses | 8,730,000 | 12,592,000 | 10,330,000 | 7,259,000 | 5,386,000 | 7,019,000 | 7,842,000 | 5,774,000 | 4,475,000 | 6,443,000 | 6,578,000 | 5,371,000 | 5,030,000 | 10,314,000 | 7,560,000 | 6,958,000 | 9,560,000 | 12,796,000 | 8,635,000 | 14,635,000 | 15,624,000 | 35,238,000 | 30,472,000 | 26,757,000 | 24,708,000 | 28,180,000 | 25,801,000 | 23,495,000 | 22,097,000 | 23,803,000 | 15,893,000 | 12,150,000 | 21,989,000 | 12,714,000 | 15,800,000 | 9,131,000 | 11,887,000 | 9,020,000 | 7,824,000 | 10,222,000 | 7,793,000 | 10,433,000 | 10,886,000 | 6,482,000 |
accrued clinical and development expenses | 2,396,000 | 3,373,000 | 5,842,000 | 3,783,000 | 2,457,000 | 1,058,000 | 864,000 | 1,966,000 | 1,399,000 | 2,246,000 | 3,272,000 | 4,006,000 | 5,022,000 | 4,932,000 | 4,078,000 | 7,627,000 | 8,922,000 | 17,010,000 | 20,607,000 | 19,457,000 | 30,903,000 | 28,799,000 | 26,944,000 | 25,229,000 | 22,658,000 | 17,587,000 | 10,907,000 | 7,404,000 | 9,207,000 | 11,876,000 | 14,100,000 | 14,508,000 | 16,435,000 | 20,487,000 | 26,386,000 | 28,036,000 | 23,859,000 | 22,650,000 | 23,640,000 | 6,652,000 | 6,674,000 | 6,628,000 | 9,435,000 | 13,869,000 |
accrued general and administrative expenses | 2,522,000 | 2,052,000 | 2,699,000 | 2,459,000 | 2,520,000 | 2,987,000 | 1,379,000 | 1,959,000 | 2,476,000 | 2,900,000 | 1,903,000 | 2,874,000 | 4,586,000 | 4,020,000 | 3,749,000 | 6,052,000 | 4,412,000 | 2,898,000 | 3,854,000 | 3,269,000 | 4,954,000 | 6,048,000 | ||||||||||||||||||||||
operating lease liabilities | 10,752,000 | 10,945,000 | 10,914,000 | 10,896,000 | 10,807,000 | 10,712,000 | 4,196,000 | 4,219,000 | 4,063,000 | 3,923,000 | 9,713,000 | 9,160,000 | 7,431,000 | 6,753,000 | 692,000 | 2,624,000 | 4,054,000 | 503,000 | 1,016,000 | 1,037,000 | 1,220,000 | 9,867,000 | 9,685,000 | 8,741,000 | 7,954,000 | 7,762,000 | 6,833,000 | 7,887,000 | 48,493,000 | |||||||||||||||
income tax payable | 5,287,000 | 5,287,000 | 4,074,000 | 26,696,000 | 5,853,000 | 5,853,000 | 120,550,000 | |||||||||||||||||||||||||||||||||||||
other accrued liabilities | 988,000 | 1,485,000 | 1,335,000 | 1,865,000 | 2,071,000 | 2,214,000 | 1,210,000 | 864,000 | 1,073,000 | 1,241,000 | 1,510,000 | 1,542,000 | 1,428,000 | 1,118,000 | 142,000 | 2,275,000 | 792,000 | 1,304,000 | 1,830,000 | 1,496,000 | 1,833,000 | 2,013,000 | 6,732,000 | 7,018,000 | 6,559,000 | 6,331,000 | 6,549,000 | 6,432,000 | 15,587,000 | 10,445,000 | 11,052,000 | 8,700,000 | 11,508,000 | 9,828,000 | 8,369,000 | 8,049,000 | 4,095,000 | 4,913,000 | 4,725,000 | 4,322,000 | 3,333,000 | 7,460,000 | 4,340,000 | 4,538,000 |
total current liabilities | 31,775,000 | 38,302,000 | 37,407,000 | 54,633,000 | 31,502,000 | 32,085,000 | 23,435,000 | 22,946,000 | 21,662,000 | 24,767,000 | 25,368,000 | 24,546,000 | 26,184,000 | 28,715,000 | 142,132,000 | 32,624,000 | 44,201,000 | 58,587,000 | 66,082,000 | 67,127,000 | 86,492,000 | 123,571,000 | 104,270,000 | 106,574,000 | 98,040,000 | 111,703,000 | 108,823,000 | 110,136,000 | 113,542,000 | 98,554,000 | 102,029,000 | 93,480,000 | 105,179,000 | 48,786,000 | 57,103,000 | 48,984,000 | 45,410,000 | 44,657,000 | 46,401,000 | 27,430,000 | 24,477,000 | 28,852,000 | 35,828,000 | 40,111,000 |
long-term operating lease liabilities | 29,752,000 | 31,758,000 | 33,681,000 | 35,561,000 | 37,349,000 | 39,108,000 | 40,785,000 | 42,441,000 | 43,840,000 | 45,236,000 | 41,118,000 | 42,521,000 | 43,763,000 | 45,407,000 | 51,381,000 | 50,642,000 | 47,415,000 | 52,681,000 | 54,353,000 | 57,768,000 | 57,026,000 | 47,220,000 | 47,823,000 | 47,631,000 | 47,199,000 | 47,725,000 | 48,620,000 | 48,565,000 | ||||||||||||||||
future royalty payment contingency | 32,795,000 | 32,795,000 | 32,213,000 | 31,640,000 | 30,977,000 | 30,334,000 | 29,691,000 | 29,061,000 | 28,417,000 | 27,788,000 | 27,165,000 | 26,556,000 | 25,988,000 | 25,438,000 | 24,888,000 | |||||||||||||||||||||||||||||
unrecognized tax benefits | 87,153,000 | 85,679,000 | 79,165,000 | 77,805,000 | 76,484,000 | 75,199,000 | 71,563,000 | 69,007,000 | 67,075,000 | 65,294,000 | 65,955,000 | 64,987,000 | 64,191,000 | 64,191,000 | 62,661,000 | |||||||||||||||||||||||||||||
other long-term liabilities | 244,000 | 313,000 | 313,000 | 1,548,000 | 1,287,000 | 1,890,000 | 4,977,000 | 4,885,000 | 5,445,000 | 5,919,000 | 7,679,000 | 7,678,000 | 7,678,000 | 1,657,000 | 1,657,000 | 2,404,000 | 2,428,000 | 2,420,000 | 2,609,000 | 1,833,000 | 2,058,000 | 1,833,000 | 9,704,000 | 9,614,000 | 9,583,000 | 21,287,000 | 8,900,000 | 14,457,000 | 14,261,000 | 24,762,000 | 28,323,000 | 28,325,000 | 36,085,000 | 26,490,000 | 18,996,000 | 18,493,000 | 8,847,000 | 3,878,000 | 3,738,000 | 2,785,000 | 2,433,000 | 1,890,000 | 986,000 | |
commitments and contingencies | ||||||||||||||||||||||||||||||||||||||||||||
shareholders’ equity | ||||||||||||||||||||||||||||||||||||||||||||
preferred shares, 0.00001 par value per share... | ||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value per share... | 1,000 | 1,000 | 1,000 | 1,000 | 1,000 | |||||||||||||||||||||||||||||||||||||||
additional paid-in capital | 1,155,215,000 | 1,156,288,000 | 1,153,299,000 | 1,149,123,000 | 1,145,083,000 | 1,141,060,000 | 1,135,599,000 | 1,131,008,000 | 1,125,677,000 | 1,122,164,000 | 1,146,948,000 | 1,172,090,000 | 1,246,506,000 | 1,295,725,000 | 1,324,247,000 | 1,410,415,000 | 1,400,566,000 | 1,387,469,000 | 1,370,402,000 | 1,358,318,000 | 1,233,060,000 | 1,222,818,000 | 1,206,524,000 | 1,191,923,000 | 1,173,204,000 | 1,024,614,000 | 1,000,094,000 | 987,209,000 | 971,508,000 | 960,721,000 | 948,844,000 | 937,437,000 | 925,968,000 | 895,226,000 | 885,315,000 | 871,871,000 | 742,726,000 | 732,334,000 | 602,117,000 | 499,232,000 | 487,064,000 | 470,895,000 | 414,875,000 | 405,221,000 |
accumulated other comprehensive income | -62,000 | 61,000 | 32,000 | -10,000 | 7,000 | 50,000 | 51,000 | 14,000 | 8,000 | 17,000 | 47,000 | 122,000 | 280,000 | 512,000 | 145,000 | 94,000 | 129,000 | 39,000 | 181,000 | 126,000 | 43,000 | 25,000 | 31,000 | 70,000 | ||||||||||||||||||||
accumulated deficit | -864,560,000 | -859,627,000 | -920,651,000 | -924,266,000 | -979,101,000 | -965,522,000 | -949,995,000 | -937,297,000 | -920,768,000 | -909,104,000 | -900,594,000 | -891,644,000 | -875,999,000 | -853,911,000 | -843,549,000 | -1,760,180,000 | -1,751,989,000 | -1,726,043,000 | -1,694,009,000 | -1,658,701,000 | -1,606,296,000 | -1,526,617,000 | -1,468,183,000 | -1,394,540,000 | -1,331,653,000 | -1,248,600,000 | -1,182,994,000 | -1,124,563,000 | -1,084,725,000 | -1,012,145,000 | -961,959,000 | -902,526,000 | -861,708,000 | |||||||||||
total shareholders’ equity | 290,594,000 | 296,723,000 | 232,681,000 | 224,848,000 | 165,983,000 | 175,545,000 | 185,654,000 | 193,689,000 | 204,868,000 | 212,995,000 | 246,130,000 | 280,161,000 | 370,559,000 | 441,800,000 | 480,578,000 | -13,445,000 | 34,387,000 | 63,407,000 | 184,117,000 | 241,127,000 | 293,946,000 | 297,873,000 | 321,584,000 | 238,537,000 | 222,545,000 | 257,674,000 | 289,115,000 | |||||||||||||||||
total liabilities and shareholders’ equity | 472,313,000 | 485,570,000 | 415,460,000 | 426,035,000 | 343,582,000 | 354,161,000 | 356,105,000 | 362,029,000 | 371,307,000 | 381,999,000 | 413,590,000 | 446,630,000 | 538,550,000 | 607,400,000 | 763,496,000 | 370,964,000 | 421,364,000 | 480,108,000 | 486,159,000 | 543,886,000 | 588,039,000 | 356,289,000 | 374,488,000 | 293,125,000 | 257,506,000 | 289,479,000 | 324,901,000 | |||||||||||||||||
future contingent milestone and royalty assets | 144,200,000 | 144,200,000 | 194,200,000 | 194,200,000 | 194,200,000 | 194,200,000 | 194,200,000 | 194,200,000 | 194,200,000 | 194,200,000 | 194,200,000 | |||||||||||||||||||||||||||||||||
prepaid clinical and development services | 73,000 | 597,000 | 2,646,000 | 2,086,000 | 2,038,000 | 1,634,000 | 979,000 | 1,524,000 | 1,513,000 | 2,645,000 | 2,311,000 | 4,742,000 | 10,245,000 | 13,242,000 | 15,913,000 | 18,792,000 | 20,374,000 | 20,761,000 | ||||||||||||||||||||||||||
tenant improvement payable to sublessee | 6,490,000 | 6,490,000 | 6,490,000 | 6,490,000 | ||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive loss | -22,000 | -41,000 | -65,000 | -225,000 | -286,000 | -15,000 | -121,000 | -45,000 | -28,000 | -36,000 | -166,000 | -331,000 | -525,000 | -854,000 | ||||||||||||||||||||||||||||||
long-term deferred revenue | 175,000 | 181,000 | 187,000 | 192,000 | 199,000 | 204,000 | 301,000 | 310,000 | 320,000 | 329,000 | 339,000 | 348,000 | 750,000 | 1,154,000 | 8,511,000 | 6,761,000 | 14,169,000 | 13,444,000 | 21,733,000 | 26,179,000 | 22,469,000 | 34,220,000 | 45,651,000 | |||||||||||||||||||||
preferred shares, 0.00001 par value: 230 shares authorized, no shares issued or outstanding | ||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 48,091 and 65,227 shares issued and outstanding at december 31, 2023 and december 31, 2022, respectively | ||||||||||||||||||||||||||||||||||||||||||||
deferred revenue | 24,000 | 24,000 | 24,000 | 24,000 | 24,000 | 24,000 | 98,000 | 98,000 | 2,902,000 | 5,690,000 | 7,661,000 | 11,523,000 | 18,204,000 | 25,062,000 | 23,193,000 | 31,575,000 | 33,751,000 | 43,311,000 | 42,515,000 | 43,402,000 | 57,239,000 | 54,478,000 | 50,162,000 | 134,000 | 142,000 | 142,000 | 218,000 | 662,000 | 1,120,000 | 271,000 | 342,000 | 310,000 | 667,000 | |||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 50,819 and 65,227 shares issued and outstanding at september 30, 2023 and december 31, 2022, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 53,694 and 65,227 shares issued and outstanding at june 30, 2023 and december 31, 2022, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 60,542 and 65,227 shares issued and outstanding at march 31, 2023 and december 31, 2022, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
amounts due from trc, llc | 35,559,000 | 43,534,000 | 43,773,000 | 27,741,000 | 42,359,000 | 53,799,000 | 48,909,000 | 35,509,000 | 26,282,000 | 28,574,000 | 16,661,000 | 20,019,000 | ||||||||||||||||||||||||||||||||
equity in net assets of trc, llc | 148,250,000 | 94,108,000 | 67,537,000 | 45,086,000 | 35,822,000 | 19,439,000 | 12,750,000 | |||||||||||||||||||||||||||||||||||||
accrued interest payable | 3,990,000 | 5,841,000 | 3,940,000 | 5,808,000 | 3,900,000 | 5,804,000 | 3,974,000 | 5,791,000 | 3,702,000 | 6,323,000 | 5,659,000 | 7,568,000 | 5,758,000 | 10,240,000 | ||||||||||||||||||||||||||||||
current portion of non-recourse notes due 2035 | 9,012,000 | 16,940,000 | 12,530,000 | 6,941,000 | 11,659,000 | 19,334,000 | ||||||||||||||||||||||||||||||||||||||
convertible senior notes due 2023 | 228,571,000 | 228,303,000 | 228,035,000 | 227,767,000 | 227,499,000 | 227,230,000 | 226,963,000 | 226,695,000 | 226,427,000 | 226,158,000 | 225,890,000 | 225,622,000 | 225,354,000 | 225,086,000 | 224,818,000 | |||||||||||||||||||||||||||||
non-recourse notes due 2035 | 396,125,000 | 384,161,000 | 371,359,000 | 375,570,000 | 375,069,000 | 375,181,000 | 372,873,000 | 384,482,000 | 375,266,000 | 373,854,000 | ||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 65,227 and 74,435 shares issued and outstanding at december 31, 2022 and december 31, 2021, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 67,366 and 74,435 shares issued and outstanding at september 30, 2022 and december 31, 2021, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
liabilities and shareholders' deficit | ||||||||||||||||||||||||||||||||||||||||||||
shareholders’ deficit | ||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 76,427 and 74,435 shares issued and outstanding at june 30, 2022 and december 31, 2021, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
total shareholders’ deficit | -349,809,000 | -351,450,000 | -338,573,000 | -323,592,000 | -300,374,000 | -373,218,000 | -303,751,000 | -261,536,000 | -202,336,000 | -157,936,000 | -223,840,000 | -182,805,000 | -137,224,000 | -113,252,000 | ||||||||||||||||||||||||||||||
total liabilities and shareholders’ deficit | 360,761,000 | 355,359,000 | 374,819,000 | 403,109,000 | 429,251,000 | 375,108,000 | 469,057,000 | 512,188,000 | 564,330,000 | 605,409,000 | 408,826,000 | 445,337,000 | 492,447,000 | 531,265,000 | ||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 76,081 and 74,435 shares issued and outstanding at march 31, 2022 and december 31, 2021, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 74,435 and 64,328 shares issued and outstanding at december 31, 2021 and december 31, 2020, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 73,698 and 64,328 shares issued and outstanding at september 30, 2021 and december 31, 2020, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 73,470 and 64,328 shares issued and outstanding at june 30, 2021 and december 31, 2020, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 65,218 and 64,328 shares issued and outstanding at march 31, 2021 and december 31, 2020, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
receivables from licensing arrangements | 1,200,000 | 10,000,000 | ||||||||||||||||||||||||||||||||||||||||||
tax receivable | 3,986,000 | 3,972,000 | 3,682,000 | 3,664,000 | 3,131,000 | 3,143,000 | 3,324,000 | 8,070,000 | ||||||||||||||||||||||||||||||||||||
current portion of non-recourse notes due 2033 | ||||||||||||||||||||||||||||||||||||||||||||
non-recourse notes due 2033 | 9,851,000 | 8,701,000 | 12,348,000 | 8,300,000 | 229,535,000 | |||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 64,328 and 57,015 shares issued and outstanding at december 31, 2020 and december 31, 2019, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 63,956 and 57,015 shares issued and outstanding at september 30, 2020 and december 31, 2019, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 63,515 and 57,015 shares issued and outstanding at june 30, 2020 and december 31, 2019, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 63,004 and 57,015 shares issued and outstanding at march 31, 2020 and december 31, 2019, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
accounts receivable | 87,000 | 111,000 | 113,000 | 620,000 | 3,024,000 | 3,434,000 | 1,973,000 | 1,576,000 | 1,346,000 | 1,233,000 | 873,000 | 1,856,000 | 1,527,000 | 783,000 | 805,000 | 565,000 | 230,000 | 90,000 | ||||||||||||||||||||||||||
deferred rent | 7,976,000 | 7,038,000 | 6,670,000 | 5,772,000 | 3,288,000 | 3,450,000 | 3,674,000 | 4,159,000 | 4,369,000 | 4,449,000 | 4,746,000 | 4,895,000 | 5,044,000 | 5,070,000 | 4,989,000 | |||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 57,015 and 55,681 shares issued and outstanding at december 31, 2019 and 2018, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
short-term restricted cash | 7,496,000 | |||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 56,762 and 55,681 shares issued and outstanding at september 30, 2019 and december 31, 2018, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
income tax receivable | 3,695,000 | |||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 56,637 and 55,681 shares issued and outstanding at june 30, 2019 and december 31, 2018, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
prepaid taxes | 310,000 | 310,000 | 314,000 | 944,000 | 926,000 | 289,000 | 242,000 | 3,083,000 | 3,168,000 | 3,150,000 | 242,000 | |||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 56,122 and 55,681 shares issued and outstanding at march 31, 2019 and december 31, 2018, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
inventories | 17,923,000 | 17,906,000 | 17,217,000 | 15,258,000 | 12,126,000 | 13,215,000 | 12,480,000 | 9,810,000 | 9,406,000 | 12,141,000 | 12,553,000 | 12,337,000 | 15,129,000 | 14,756,000 | ||||||||||||||||||||||||||||||
liabilities and shareholders' (deficit) equity | ||||||||||||||||||||||||||||||||||||||||||||
shareholders’ (deficit) equity | ||||||||||||||||||||||||||||||||||||||||||||
preferred shares, 0.00001 par value: 230 shares authorized, no shares issued or outstanding at december 31, 2018 and 2017, respectively | ||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 55,681 and 54,381 shares issued and outstanding at december 31, 2018 and 2017, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
total shareholders’ (deficit) equity | -51,589,000 | |||||||||||||||||||||||||||||||||||||||||||
total liabilities and shareholders’ (deficit) equity | 560,235,000 | |||||||||||||||||||||||||||||||||||||||||||
convertible senior notes | 224,550,000 | 224,282,000 | 224,014,000 | 223,478,000 | 223,210,000 | 222,942,000 | ||||||||||||||||||||||||||||||||||||||
preferred shares, 0.00001 par value: 230 shares authorized, no shares issued or outstanding | ||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 55,410 and 54,381 shares issued and outstanding at september 30, 2018 and december 31, 2017, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 55,104 and 54,381 shares issued and outstanding at june 30, 2018 and december 31, 2017, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized; 54,798 and 54,381 shares issued and outstanding at march 31, 2018 and december 31, 2017, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
other investments | 8,000,000 | 8,000,000 | 8,000,000 | 8,000,000 | 8,000,000 | 8,000,000 | ||||||||||||||||||||||||||||||||||||||
liabilities and shareholders’ equity | ||||||||||||||||||||||||||||||||||||||||||||
preferred shares, 0.00001 par value: 230 shares authorized, no shares issued or outstanding at september 30, 2017 and december 31, 2016, respectively | ||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized at september 30, 2017 and december 31, 2016; 54,087 and 52,833 shares issued and outstanding at september 30, 2017 and december 31, 2016, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
preferred shares, 0.00001 par value: 230 shares authorized, no shares issued or outstanding at june 30, 2017 and december 31, 2016, respectively | ||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized at june 30, 2017 and december 31, 2016; 53,829 and 52,833 shares issued and outstanding at june 30, 2017 and december 31, 2016, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
preferred shares, 0.00001 par value: 230 shares authorized, no shares issued or outstanding at march 31, 2017 and december 31, 2016, respectively | ||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized at march 31, 2017 and december 31, 2016; 53,290 and 52,833 shares issued and outstanding at march 31, 2017 and december 31, 2016, respectively | 1,000 | |||||||||||||||||||||||||||||||||||||||||||
preferred shares, 0.00001 par value: 230 shares authorized, no shares issued or outstanding at september 30, 2016 and december 31, 2015, respectively | ||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized at september 30, 2016 and december 31, 2015; 48,092 and 37,981 shares issued and outstanding at september 30, 2016 and december 31, 2015, respectively | ||||||||||||||||||||||||||||||||||||||||||||
preferred shares, 0.00001 par value: 230 shares authorized, no shares issued or outstanding at june 30, 2016 and december 31, 2015, respectively | ||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized at june 30, 2016 and december 31, 2015; 47,853 and 37,981 shares issued and outstanding at june 30, 2016 and december 31, 2015, respectively | ||||||||||||||||||||||||||||||||||||||||||||
preferred shares, 0.00001 par value: 230 shares authorized, no shares issued or outstanding at march 31, 2016 and december 31, 2015, respectively | ||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized at march 31, 2016 and december 31, 2015; 41,452 and 37,981 shares issued and outstanding at march 31, 2016 and december 31, 2015, respectively | ||||||||||||||||||||||||||||||||||||||||||||
prepaid and other current assets | 9,705,000 | 10,394,000 | 6,758,000 | 6,454,000 | 3,446,000 | |||||||||||||||||||||||||||||||||||||||
preferred shares, 0.00001 par value: 230 shares authorized, no shares issued or outstanding at september 30, 2015 and december 31, 2014, respectively | ||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized at september 30, 2015 and december 31, 2014; 33,935 and 32,221 shares issued and outstanding at september 30, 2015 and december 31, 2014, respectively | ||||||||||||||||||||||||||||||||||||||||||||
marketable securities | 17,794,000 | 38,521,000 | 65,638,000 | 38,231,000 | ||||||||||||||||||||||||||||||||||||||||
liabilities and shareholders’ equity: | ||||||||||||||||||||||||||||||||||||||||||||
preferred shares, 0.00001 par value: 230 shares authorized, no shares issued or outstanding at june 30, 2015 and december 31, 2014 | ||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized at june 30, 2015 and december 31, 2014; 33,939 and 32,221 shares issued and outstanding at june 30, 2015 and december 31, 2014 | ||||||||||||||||||||||||||||||||||||||||||||
preferred shares, 0.00001 par value: 230 shares authorized, no shares issued or outstanding at march 31, 2015 and december 31, 2014 | ||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized at march 31, 2015 and december 31, 2014; 33,802 and 32,221 shares issued and outstanding at march 31, 2015 and december 31, 2014 | ||||||||||||||||||||||||||||||||||||||||||||
liabilities: | ||||||||||||||||||||||||||||||||||||||||||||
income taxes payable | 5,216,000 | |||||||||||||||||||||||||||||||||||||||||||
shareholders’ equity and parent company deficit | ||||||||||||||||||||||||||||||||||||||||||||
preferred shares, 0.00001 par value: 230 shares authorized, no shares issued or outstanding at september 30, 2014 | ||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized at september 30, 2014; 32,228 shares issued and outstanding at september 30, 2014 | ||||||||||||||||||||||||||||||||||||||||||||
parent company deficit | ||||||||||||||||||||||||||||||||||||||||||||
total shareholders’ equity and parent company deficit | 339,821,000 | 384,759,000 | ||||||||||||||||||||||||||||||||||||||||||
total liabilities, shareholders’ equity and parent company deficit | 381,705,000 | 430,588,000 | ||||||||||||||||||||||||||||||||||||||||||
short-term investments | 80,997,000 | |||||||||||||||||||||||||||||||||||||||||||
receivable from theravance, inc. | 15,243,000 | |||||||||||||||||||||||||||||||||||||||||||
deferred revenue, current | 5,723,000 | |||||||||||||||||||||||||||||||||||||||||||
deferred revenue, non-current | 729,000 | |||||||||||||||||||||||||||||||||||||||||||
preferred shares, 0.00001 par value: 230 shares authorized, no shares issued or outstanding at june 30, 2014 | ||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, 0.00001 par value: 200,000 shares authorized at june 30, 2014; 32,260 shares issued and outstanding at june 30, 2014 |
Cashflow Statements:
Quarterly
Annual
| Unit: USD | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
operating activities | |||||||||||||||||||||||||||||||||||||||||||||
net loss | -4,933,000 | -13,579,000 | -15,527,000 | -12,698,000 | -16,529,000 | -11,664,000 | -15,645,000 | -22,088,000 | -8,191,000 | -25,946,000 | -32,034,000 | -35,308,000 | -52,405,000 | -79,679,000 | -58,434,000 | -73,643,000 | -62,887,000 | -83,053,000 | -65,606,000 | -58,431,000 | -39,838,000 | -72,580,000 | -50,186,000 | -59,433,000 | -40,818,000 | -65,087,000 | -66,877,000 | -66,287,000 | -65,319,000 | -33,961,000 | -47,225,000 | -42,150,000 | -47,315,000 | -47,604,000 | -42,474,000 | -54,495,000 | -58,215,000 | -60,018,000 | |||||||
adjustments to reconcile net loss to net cash from operating activities: | |||||||||||||||||||||||||||||||||||||||||||||
depreciation and amortization | 381,000 | 399,000 | 405,000 | 409,000 | 413,000 | 422,000 | 429,000 | 427,000 | 432,000 | 392,000 | 432,000 | 552,000 | 625,000 | 659,000 | 655,000 | 1,261,000 | 1,141,000 | 1,361,000 | 1,625,000 | 1,387,000 | 1,539,000 | 1,404,000 | 1,360,000 | 1,610,000 | 2,424,000 | 1,765,000 | 1,809,000 | 1,551,000 | 1,316,000 | 858,000 | 618,000 | 790,000 | 900,000 | 950,000 | 976,000 | 1,083,000 | 791,000 | 454,000 | 699,000 | 1,075,000 | 686,000 | 732,000 | |||
amortization and accretion on investment securities | -602,000 | -1,310,000 | -771,000 | -422,000 | -327,000 | -780,000 | -796,000 | ||||||||||||||||||||||||||||||||||||||
future royalty payment contingency interest accretion | 582,000 | 573,000 | 663,000 | 643,000 | 643,000 | 630,000 | 644,000 | 629,000 | 623,000 | 609,000 | 568,000 | 550,000 | |||||||||||||||||||||||||||||||||
share-based compensation | 4,504,000 | 4,480,000 | 4,576,000 | 4,543,000 | 4,877,000 | 5,826,000 | 4,963,000 | 5,375,000 | 5,229,000 | 5,824,000 | 6,262,000 | 6,264,000 | 7,021,000 | 6,950,000 | 8,530,000 | 9,709,000 | 14,545,000 | 16,918,000 | 14,370,000 | 14,941,000 | 15,832,000 | 15,551,000 | 15,564,000 | 16,585,000 | 15,276,000 | 23,912,000 | 13,019,000 | 11,299,000 | 12,220,000 | 11,714,000 | 11,746,000 | 13,855,000 | 13,998,000 | 10,685,000 | 10,398,000 | 10,269,000 | 9,895,000 | 9,904,000 | 11,330,000 | 12,250,000 | 14,663,000 | 15,626,000 | 9,350,000 | ||
amortization of right-of-use assets | 1,056,000 | 1,107,000 | 1,002,000 | 940,000 | 966,000 | 1,053,000 | 1,129,000 | 1,131,000 | 1,101,000 | 1,428,000 | 907,000 | 786,000 | 1,031,000 | 1,705,000 | 970,000 | 973,000 | 341,000 | 1,028,000 | 1,006,000 | 1,009,000 | 743,000 | 1,131,000 | 793,000 | 963,000 | 457,000 | 195,000 | 1,013,000 | 1,030,000 | 986,000 | ||||||||||||||||
deferred income taxes | -2,999,000 | 30,000 | 994,000 | -10,691,000 | -1,852,000 | -6,589,000 | 90,000 | -561,000 | -513,000 | ||||||||||||||||||||||||||||||||||||
other | 42,000 | 6,000 | -22,000 | -34,000 | -39,000 | -25,000 | 203,000 | -214,000 | 46,000 | -53,000 | -38,000 | -13,000 | 9,000 | -2,000 | 95,000 | 37,000 | 16,000 | 25,000 | -47,000 | 869,000 | -890,000 | 209,000 | 53,000 | ||||||||||||||||||||||
changes in operating assets and liabilities: | |||||||||||||||||||||||||||||||||||||||||||||
receivables from collaborative and licensing arrangements | 29,954,000 | 3,652,000 | -6,566,000 | 3,087,000 | -1,595,000 | -2,546,000 | 365,000 | 2,810,000 | -417,000 | -1,261,000 | -3,526,000 | 4,515,000 | -2,671,000 | -1,626,000 | -211,000 | 1,788,000 | -64,000 | -1,781,000 | -305,000 | 3,953,000 | -3,469,000 | -986,000 | 4,001,000 | 6,582,000 | |||||||||||||||||||||
receivables from milestones and royalty assets | 50,000,000 | 0 | 0 | 50,000,000 | |||||||||||||||||||||||||||||||||||||||||
prepaid clinical and development services | 0 | 0 | 0 | 73,000 | 524,000 | 2,049,000 | -560,000 | -48,000 | -405,000 | -654,000 | 546,000 | -13,000 | 1,133,000 | -334,000 | 2,431,000 | 5,503,000 | 2,997,000 | 2,671,000 | 2,879,000 | 1,582,000 | 387,000 | ||||||||||||||||||||||||
other prepaid and current assets | 1,666,000 | -814,000 | -1,179,000 | -1,515,000 | 148,000 | 3,473,000 | -1,392,000 | 1,284,000 | 4,034,000 | -2,606,000 | -1,220,000 | -1,496,000 | 1,401,000 | 444,000 | -3,767,000 | 183,000 | 2,436,000 | 2,966,000 | 1,894,000 | -2,315,000 | 322,000 | -53,000 | 3,765,000 | -7,631,000 | 1,592,000 | 47,000 | 1,726,000 | -272,000 | -2,135,000 | -1,907,000 | 2,470,000 | -1,385,000 | -1,578,000 | -770,000 | |||||||||||
right-of-use lease assets | 314,000 | -28,000 | 41,000 | -3,000 | -42,000 | -73,000 | -86,000 | -370,000 | -178,000 | -141,000 | -29,000 | -35,000 | -109,000 | -1,837,000 | 102,000 | ||||||||||||||||||||||||||||||
other assets | 1,025,000 | 251,000 | -413,000 | -1,245,000 | 330,000 | -122,000 | 241,000 | 144,000 | 148,000 | -4,542,000 | 1,558,000 | 481,000 | 1,270,000 | -2,059,000 | -1,598,000 | -146,000 | 1,000 | 34,000 | -2,003,000 | 932,000 | 65,000 | -1,393,000 | 614,000 | 26,000 | -99,000 | -361,000 | 1,000 | 160,000 | -74,000 | 266,000 | 456,000 | 255,000 | |||||||||||||
accounts payable | -1,468,000 | 355,000 | 538,000 | -733,000 | 166,000 | 788,000 | -220,000 | -2,000 | 184,000 | -348,000 | 271,000 | -919,000 | 1,002,000 | -3,762,000 | 2,176,000 | 1,593,000 | -1,619,000 | -5,740,000 | -1,820,000 | 5,099,000 | -1,073,000 | 1,525,000 | -3,879,000 | 4,858,000 | 1,154,000 | -3,731,000 | 4,948,000 | -2,051,000 | -3,440,000 | 5,240,000 | 646,000 | -1,862,000 | -449,000 | -1,258,000 | 2,794,000 | 2,004,000 | |||||||||
accrued personnel-related expenses, accrued clinical and development expenses, and other accrued liabilities | -4,867,000 | -1,275,000 | 3,606,000 | 3,192,000 | -1,514,000 | 2,991,000 | 733,000 | 1,140,000 | -3,396,000 | -438,000 | -123,000 | -2,197,000 | -4,337,000 | 4,379,000 | -7,330,000 | -791,000 | -10,344,000 | -652,000 | -3,448,000 | -15,826,000 | -17,299,000 | 6,161,000 | 5,575,000 | 4,796,000 | -10,549,000 | 20,472,000 | 5,734,000 | -8,296,000 | -7,284,000 | 3,808,000 | 4,725,000 | -13,973,000 | -5,076,000 | 2,458,000 | 14,000 | 5,718,000 | 159,000 | 174,000 | 4,563,000 | ||||||
operating lease liabilities | -2,199,000 | -1,892,000 | -1,862,000 | -1,699,000 | -1,664,000 | 4,839,000 | -1,680,000 | -1,242,000 | -1,256,000 | -1,672,000 | -850,000 | 487,000 | -966,000 | 87,000 | -1,193,000 | 1,797,000 | -1,715,000 | -2,185,000 | -1,275,000 | 559,000 | 1,159,000 | -421,000 | 1,136,000 | 1,178,000 | -293,000 | -10,000 | -936,000 | ||||||||||||||||||
unrecognized tax benefits | 1,474,000 | 6,515,000 | 1,360,000 | 1,321,000 | 1,285,000 | 3,637,000 | 2,555,000 | 1,933,000 | 1,781,000 | ||||||||||||||||||||||||||||||||||||
other long-term liabilities | -69,000 | -1,000 | -1,000 | 1,000 | 68,000 | -575,000 | 4,000 | 0 | 39,000 | 6,252,000 | 969,000 | 794,000 | -468,000 | -104,000 | -404,000 | -25,000 | 8,000 | -189,000 | 224,000 | -7,871,000 | 90,000 | 31,000 | 144,000 | 540,000 | -5,557,000 | 196,000 | 73,000 | -4,911,000 | -3,000 | -6,411,000 | 1,267,000 | 7,481,000 | 505,000 | 5,354,000 | 4,948,000 | -82,000 | 590,000 | -640,000 | 402,000 | 321,000 | |||||
net cash from operating activities | 73,279,000 | -6,064,000 | -6,508,000 | 208,074,000 | 43,039,000 | -902,000 | -5,196,000 | -4,415,000 | -1,022,000 | -854,000 | -2,486,000 | -12,436,000 | -11,221,000 | -124,055,000 | -22,137,000 | -14,730,000 | -26,069,000 | -42,434,000 | -45,446,000 | -50,113,000 | -69,865,000 | -64,925,000 | -77,031,000 | -53,346,000 | -55,101,000 | -64,352,000 | -44,622,000 | -48,030,000 | -81,193,000 | -52,178,000 | -48,977,000 | -61,537,000 | 49,825,000 | ||||||||||||
capital expenditures | 0 | -8,000 | 0 | 0 | -190,000 | -15,000 | -36,000 | -91,000 | -677,000 | -21,000 | -852,000 | -938,000 | -266,000 | 57,000 | -113,000 | -250,000 | -444,000 | -1,039,000 | -156,000 | -1,767,000 | -1,244,000 | -2,050,000 | -2,368,000 | -954,000 | -1,303,000 | -77,000 | -576,000 | -1,220,000 | -1,500,000 | -1,875,000 | -1,094,000 | -2,771,000 | |||||||||||||
free cash flows | 73,279,000 | -6,072,000 | -6,508,000 | 208,074,000 | -1,092,000 | -5,211,000 | -4,451,000 | -1,113,000 | -1,531,000 | -2,507,000 | -13,288,000 | -12,159,000 | -124,321,000 | -22,080,000 | -14,843,000 | -26,319,000 | -42,878,000 | -46,485,000 | -50,269,000 | -71,632,000 | -66,169,000 | -79,081,000 | -55,714,000 | -56,055,000 | -65,655,000 | -44,699,000 | -48,606,000 | -82,413,000 | -53,678,000 | -50,852,000 | -62,631,000 | 47,054,000 | |||||||||||||
investing activities | |||||||||||||||||||||||||||||||||||||||||||||
purchases of marketable securities | -43,407,000 | -64,929,000 | -124,746,000 | -56,574,000 | -1,968,000 | -37,721,000 | -44,882,000 | -31,238,000 | -26,902,000 | 0 | 0 | -1,000 | -134,533,000 | -9,885,000 | -39,497,000 | -35,589,000 | -18,174,000 | -53,531,000 | -64,760,000 | -39,978,000 | -36,000 | -64,431,000 | -57,061,000 | -215,717,000 | -64,778,000 | -57,486,000 | -158,384,000 | -59,890,000 | -148,138,000 | -16,849,000 | -64,500,000 | -47,073,000 | -54,839,000 | ||||||||||||
maturities of marketable securities | 96,000,000 | 65,525,000 | 24,500,000 | 20,350,000 | 32,600,000 | 40,051,000 | 27,498,000 | 28,243,000 | 44,021,000 | 0 | 0 | 1,935,000 | 29,500,000 | 49,300,000 | 17,001,000 | 43,200,000 | 48,499,000 | 64,799,000 | 30,000,000 | 75,900,000 | 115,500,000 | 118,000,000 | 125,615,000 | 36,500,000 | 119,203,000 | 72,850,000 | 134,800,000 | 54,170,000 | 77,198,000 | 97,742,000 | 113,022,000 | 90,129,000 | 46,299,000 | 69,419,000 | 84,688,000 | 36,282,000 | 27,750,000 | 23,445,000 | 17,069,000 | 62,763,000 | 42,409,000 | 53,470,000 | |||
net cash from investing activities | 52,593,000 | 588,000 | -100,246,000 | -36,258,000 | 30,632,000 | 15,686,000 | -17,399,000 | -3,031,000 | 17,028,000 | -677,000 | -21,000 | 11,047,000 | -43,046,000 | 39,161,000 | 1,075,409,000 | 7,515,000 | 31,924,000 | 10,824,000 | -35,793,000 | 35,766,000 | 113,697,000 | 52,368,000 | 66,539,000 | -176,589,000 | 68,403,000 | 14,061,000 | -23,656,000 | -1,296,000 | -72,160,000 | 99,393,000 | 46,647,000 | 41,962,000 | -11,294,000 | 62,089,000 | 41,299,000 | 42,154,000 | |||||||||
financing activities | |||||||||||||||||||||||||||||||||||||||||||||
proceeds from the sale of ordinary shares | 0 | 0 | 0 | 20,000 | 30,000 | 25,000 | 0 | 0 | 0 | 0 | 0 | 139,915,000 | |||||||||||||||||||||||||||||||||
proceeds from option exercises | 241,000 | 488,000 | 0 | 0 | 2,000 | 3,000 | 401,000 | 24,000 | 733,000 | 203,000 | 169,000 | 428,000 | 2,291,000 | 254,000 | 87,000 | 1,225,000 | 46,000 | 35,000 | 373,000 | 2,504,000 | 2,816,000 | ||||||||||||||||||||||||
repurchase of shares to satisfy tax withholding | -5,818,000 | -1,979,000 | -678,000 | -503,000 | -874,000 | -528,000 | -397,000 | -463,000 | -1,271,000 | -518,000 | -512,000 | -583,000 | -887,000 | -993,000 | -662,000 | -347,000 | -1,448,000 | -455,000 | -2,286,000 | -727,000 | -5,593,000 | -814,000 | -987,000 | -1,144,000 | -6,804,000 | -430,000 | -562,000 | -494,000 | -1,687,000 | -1,355,000 | -1,547,000 | -5,190,000 | -1,715,000 | ||||||||||||
net cash from financing activities | -5,577,000 | -1,491,000 | -400,000 | -503,000 | -854,000 | -365,000 | -372,000 | -44,000 | -1,716,000 | -30,609,000 | -31,404,000 | -80,680,000 | -56,240,000 | -35,472,000 | -722,026,000 | 140,000 | -1,448,000 | 149,000 | -2,286,000 | 105,285,000 | -11,288,000 | 743,000 | -963,000 | 1,873,000 | 261,432,000 | -1,544,000 | -134,000 | 4,402,000 | -1,433,000 | 229,604,000 | -322,000 | -2,402,000 | -1,680,000 | 26,044,000 | |||||||||||
net increase in cash, cash equivalents, and restricted cash | 120,295,000 | -6,967,000 | -107,154,000 | 171,313,000 | 72,817,000 | -7,490,000 | 14,290,000 | -32,140,000 | -110,507,000 | -120,366,000 | 331,246,000 | -7,075,000 | 4,407,000 | -31,461,000 | -83,525,000 | 90,938,000 | 32,544,000 | -11,815,000 | -11,453,000 | -228,063,000 | 274,734,000 | -51,835,000 | -68,412,000 | -44,924,000 | -154,786,000 | 276,819,000 | -2,652,000 | -21,977,000 | 36,851,000 | ||||||||||||||||
cash, cash equivalents, and restricted cash at beginning of period | 168,642,000 | 0 | 0 | 0 | 38,633,000 | 0 | 0 | 0 | 40,381,000 | 0 | 0 | 0 | 299,008,000 | 0 | 0 | 0 | 90,796,000 | 0 | 0 | 0 | 82,300,000 | 0 | 0 | 0 | 58,897,000 | 0 | 0 | 0 | 378,854,000 | 0 | 0 | 0 | 89,813,000 | ||||||||||||
cash, cash equivalents, and restricted cash at end of period | 288,937,000 | -6,967,000 | -107,154,000 | 171,313,000 | 111,450,000 | 14,419,000 | -22,967,000 | -7,490,000 | 54,671,000 | -32,140,000 | -33,911,000 | -82,069,000 | 188,501,000 | -120,366,000 | 331,246,000 | -7,075,000 | 95,203,000 | -31,461,000 | -83,525,000 | 90,938,000 | 114,844,000 | -11,815,000 | -11,453,000 | -228,063,000 | 333,631,000 | -51,835,000 | -68,412,000 | -44,924,000 | 224,068,000 | 276,819,000 | -2,652,000 | -21,977,000 | 126,664,000 | ||||||||||||
supplemental disclosure of cash flow information | |||||||||||||||||||||||||||||||||||||||||||||
cash paid for income taxes | -351,000 | 6,210,000 | 12,769,000 | 8,901,000 | 4,000 | 97,000 | 0 | 21,000 | -9,000 | 10,000 | 0 | 7,000 | 7,000 | 117,940,000 | 1,000 | -275,000 | -3,826,000 | 0 | 0 | 23,000 | -9,000 | 0 | 1,000 | -2,289,000 | 9,494,000 | ||||||||||||||||||||
net income | 61,024,000 | 3,615,000 | -8,510,000 | -10,362,000 | |||||||||||||||||||||||||||||||||||||||||
adjustments to reconcile net income to net cash from operating activities: | |||||||||||||||||||||||||||||||||||||||||||||
loss on disposal of property and equipment | 0 | 0 | 163,000 | -163,000 | -1,000 | 1,000 | 1,323,000 | 29,000 | |||||||||||||||||||||||||||||||||||||
loss on impairment of long-lived assets | 0 | 1,562,000 | |||||||||||||||||||||||||||||||||||||||||||
receivables from collaborative arrangements | -3,616,000 | 6,845,000 | 2,229,000 | -6,146,000 | -42,000 | -1,020,000 | 4,264,000 | 2,321,000 | 1,437,000 | 12,367,000 | -179,000 | 88,000 | 844,000 | ||||||||||||||||||||||||||||||||
future contingent milestone and royalty assets | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||
purchases of property and equipment | -8,000 | 0 | -190,000 | -15,000 | -36,000 | -91,000 | -677,000 | -21,000 | -852,000 | -938,000 | -266,000 | 57,000 | -113,000 | -250,000 | -444,000 | -1,039,000 | -156,000 | -1,767,000 | -1,244,000 | -2,050,000 | -2,368,000 | -954,000 | -1,303,000 | -77,000 | -576,000 | -1,220,000 | -1,500,000 | -1,875,000 | -1,094,000 | -2,771,000 | |||||||||||||||
purchase of derivative | |||||||||||||||||||||||||||||||||||||||||||||
sale of short-term investments and marketable securities | 0 | 0 | 8,662,000 | 62,715,000 | 12,000 | ||||||||||||||||||||||||||||||||||||||||
ordinary share repurchases | 0 | 0 | 0 | -445,000 | -30,264,000 | -30,891,000 | -80,543,000 | -55,353,000 | |||||||||||||||||||||||||||||||||||||
proceeds from espp purchases | 133,000 | 0 | 173,000 | -1,000 | 314,000 | 1,000 | 604,000 | 0 | 1,156,000 | 0 | 869,000 | 0 | 1,431,000 | 0 | 0 | 0 | |||||||||||||||||||||||||||||
income tax payable | -22,622,000 | ||||||||||||||||||||||||||||||||||||||||||||
deferred revenue | -199,000 | -6,000 | -5,000 | -6,000 | -6,000 | -6,000 | -171,000 | -9,000 | -2,815,000 | -2,796,000 | -1,981,000 | -3,871,000 | -7,083,000 | -7,262,000 | -5,488,000 | -6,632,000 | -9,584,000 | -8,835,000 | -7,493,000 | -5,333,000 | -10,042,000 | -8,990,000 | -7,115,000 | 95,371,000 | 5,000 | -2,000 | 17,000 | -423,000 | -236,000 | 1,141,000 | -163,000 | 173,000 | 212,000 | ||||||||||||
proceeds from the sale of property and equipment | 0 | 0 | 1,303,000 | 210,000 | 0 | 0 | 17,000 | 1,849,000 | 0 | 29,000 | 34,000 | ||||||||||||||||||||||||||||||||||
net decrease in cash, cash equivalents, and restricted cash | 14,419,000 | ||||||||||||||||||||||||||||||||||||||||||||
supplemental disclosure of non-cash activities | |||||||||||||||||||||||||||||||||||||||||||||
recognition of tenant improvement allowance assigned to sublease | 0 | 0 | 0 | 6,490,000 | |||||||||||||||||||||||||||||||||||||||||
amortization and accretion income | -354,000 | -403,000 | -402,000 | -414,000 | -678,000 | -339,000 | -311,000 | -33,000 | 2,000 | 1,000 | -22,000 | 20,000 | 11,000 | -56,000 | -169,000 | -318,000 | -536,000 | -852,000 | -903,000 | -1,067,000 | -629,000 | ||||||||||||||||||||||||
less: net income from discontinued operations | -3,894,000 | ||||||||||||||||||||||||||||||||||||||||||||
net loss from continuing operations | -8,510,000 | -8,950,000 | -15,645,000 | -22,088,000 | -14,256,000 | ||||||||||||||||||||||||||||||||||||||||
gain on sale of velusetrag | 0 | 12,000 | |||||||||||||||||||||||||||||||||||||||||||
loss on extinguishment of debt | 0 | 0 | 0 | 0 | 15,464,000 | ||||||||||||||||||||||||||||||||||||||||
accrued interest payable | 0 | -1,296,000 | -1,851,000 | 1,901,000 | -1,868,000 | 1,908,000 | -1,904,000 | 1,830,000 | -1,817,000 | 2,089,000 | -2,621,000 | 664,000 | -1,909,000 | 1,810,000 | |||||||||||||||||||||||||||||||
net cash from operating activities - continuing operations | -854,000 | -2,486,000 | -12,436,000 | -11,221,000 | 54,913,000 | ||||||||||||||||||||||||||||||||||||||||
net cash from operating activities - discontinued operations | -178,968,000 | ||||||||||||||||||||||||||||||||||||||||||||
proceeds from the sale of velusetrag | 0 | ||||||||||||||||||||||||||||||||||||||||||||
net cash from investing activities - continuing operations | -677,000 | -21,000 | 11,047,000 | -43,046,000 | 39,161,000 | ||||||||||||||||||||||||||||||||||||||||
net cash from investing activities - discontinued operations | 0 | ||||||||||||||||||||||||||||||||||||||||||||
proceeds from ampreloxetine funding | 0 | ||||||||||||||||||||||||||||||||||||||||||||
principal payment on 2035 notes | 0 | 0 | 0 | -5,032,000 | -5,698,000 | ||||||||||||||||||||||||||||||||||||||||
principal payment on 2023 notes | 0 | ||||||||||||||||||||||||||||||||||||||||||||
net cash from financing activities - continuing operations | -30,609,000 | -31,404,000 | -80,680,000 | -56,240,000 | -35,472,000 | ||||||||||||||||||||||||||||||||||||||||
net cash from financing activities - discontinued operations | 0 | ||||||||||||||||||||||||||||||||||||||||||||
cash paid for interest | 0 | 7,117,000 | 10,514,000 | 4,613,000 | 13,062,000 | 3,477,000 | 8,105,000 | 14,385,000 | 3,737,000 | 0 | 12,396,000 | 7,891,000 | 9,081,000 | 5,344,000 | 3,737,000 | 0 | 0 | ||||||||||||||||||||||||||||
supplemental disclosure of non-cash investing and financing activities | |||||||||||||||||||||||||||||||||||||||||||||
gain from lease modification | 0 | ||||||||||||||||||||||||||||||||||||||||||||
net decrease increase in cash, cash equivalents, and restricted cash | |||||||||||||||||||||||||||||||||||||||||||||
undistributed earnings from trc, llc | -18,583,000 | -18,596,000 | -22,206,000 | -25,296,000 | -1,765,000 | 4,751,000 | |||||||||||||||||||||||||||||||||||||||
interest payable on 2023 notes | |||||||||||||||||||||||||||||||||||||||||||||
ampreloxetine interest accretion | 550,000 | ||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||
proceed from issuance of 2035 notes | |||||||||||||||||||||||||||||||||||||||||||||
gain on disposal of property and equipment | 0 | 122,000 | -218,000 | ||||||||||||||||||||||||||||||||||||||||||
repurchases of ordinary shares | |||||||||||||||||||||||||||||||||||||||||||||
interest shortfall on 2035 notes | 2,660,000 | 4,712,000 | 0 | 7,499,000 | 9,051,000 | ||||||||||||||||||||||||||||||||||||||||
accounts receivable | 86,000 | 145,000 | -118,000 | 507,000 | 2,404,000 | 410,000 | -1,461,000 | 280,000 | 983,000 | -329,000 | 395,000 | -87,000 | 196,000 | ||||||||||||||||||||||||||||||||
tax receivable | -295,000 | 337,000 | 0 | 0 | 3,099,000 | 0 | 0 | 5,092,000 | |||||||||||||||||||||||||||||||||||||
proceeds from the sale of marketable securities | 14,000 | 1,000 | 4,995,000 | 14,932,000 | |||||||||||||||||||||||||||||||||||||||||
proceeds from the sale of vibativ business | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of 2035 notes | 0 | 0 | 0 | 380,000,000 | |||||||||||||||||||||||||||||||||||||||||
payment of issuance costs on 2035 notes | 0 | 0 | -261,000 | -5,065,000 | |||||||||||||||||||||||||||||||||||||||||
payment of redemption premium on 2033 notes | 0 | 0 | 0 | -11,470,000 | |||||||||||||||||||||||||||||||||||||||||
principal payment on 2033 notes | 0 | 0 | 0 | -235,347,000 | |||||||||||||||||||||||||||||||||||||||||
right-of-use assets obtained in exchange for lease obligations | 0 | 0 | 0 | 49,847,000 | |||||||||||||||||||||||||||||||||||||||||
net gain from the sale of vibativ business | |||||||||||||||||||||||||||||||||||||||||||||
inventory | |||||||||||||||||||||||||||||||||||||||||||||
deferred rent | 938,000 | 368,000 | 898,000 | 2,104,000 | |||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of 2033 notes | |||||||||||||||||||||||||||||||||||||||||||||
amounts due from trc, llc | -13,403,000 | -9,229,000 | 2,295,000 | ||||||||||||||||||||||||||||||||||||||||||
other-than-temporary impairment loss | |||||||||||||||||||||||||||||||||||||||||||||
inventory write-down | 1,000 | 0 | 109,000 | 10,000 | |||||||||||||||||||||||||||||||||||||||||
prepaid taxes | -18,000 | -2,908,000 | 12,522,000 | ||||||||||||||||||||||||||||||||||||||||||
inventories | -1,077,000 | -201,000 | 20,000 | -371,000 | 140,000 | 23,000 | 134,000 | -241,000 | |||||||||||||||||||||||||||||||||||||
proceeds from the sale of fixed assets | 0 | ||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of notes | |||||||||||||||||||||||||||||||||||||||||||||
principal payment on notes | |||||||||||||||||||||||||||||||||||||||||||||
reversal of inventory purchase commitment liability | 0 | ||||||||||||||||||||||||||||||||||||||||||||
undistributed earnings from investment in trc, llc | 3,356,000 | -8,366,000 | -6,229,000 | -2,349,000 | -1,170,000 | ||||||||||||||||||||||||||||||||||||||||
long-term portion of lease liabilities | -910,000 | ||||||||||||||||||||||||||||||||||||||||||||
cash received for income taxes | 4,473,000 | ||||||||||||||||||||||||||||||||||||||||||||
excess tax benefits from share-based compensation | |||||||||||||||||||||||||||||||||||||||||||||
proceeds from the sales of fixed assets | 0 | 0 | 0 | 17,000 | |||||||||||||||||||||||||||||||||||||||||
proceeds from sale of ordinary shares | -48,000 | ||||||||||||||||||||||||||||||||||||||||||||
cash received from income taxes | |||||||||||||||||||||||||||||||||||||||||||||
net cash provided by financing activities | -789,000 | 481,000 | 120,270,000 | 26,020,000 | -82,000 | 324,098,000 | 46,419,000 | ||||||||||||||||||||||||||||||||||||||
net increase in cash and cash equivalents | 19,560,000 | 16,096,000 | 30,024,000 | -3,809,000 | 11,684,000 | -145,971,000 | |||||||||||||||||||||||||||||||||||||||
cash and cash equivalents at beginning of period | 0 | 0 | 344,709,000 | 0 | 0 | 112,707,000 | 0 | 0 | 89,215,000 | ||||||||||||||||||||||||||||||||||||
cash and cash equivalents at end of period | -48,325,000 | -30,319,000 | 169,945,000 | -61,791,000 | 19,560,000 | 128,803,000 | 30,024,000 | -3,809,000 | 100,899,000 | -145,971,000 | |||||||||||||||||||||||||||||||||||
cash paid (received) for income taxes | 7,912,000 | ||||||||||||||||||||||||||||||||||||||||||||
receivable from innoviva, inc. | |||||||||||||||||||||||||||||||||||||||||||||
purchases of property, equipment, and capitalized software | |||||||||||||||||||||||||||||||||||||||||||||
net cash (used in) provided by investing activities | |||||||||||||||||||||||||||||||||||||||||||||
net cash (used in) provided by financing activities | |||||||||||||||||||||||||||||||||||||||||||||
non-cash revenue from collaboration arrangements | |||||||||||||||||||||||||||||||||||||||||||||
income taxes payable | |||||||||||||||||||||||||||||||||||||||||||||
net proceeds from sale of ordinary shares | 17,000 | 117,422,000 | 27,802,000 | ||||||||||||||||||||||||||||||||||||||||||
proceeds from option exercise | 1,090,000 | ||||||||||||||||||||||||||||||||||||||||||||
net (decrease) increase in cash and cash equivalents | |||||||||||||||||||||||||||||||||||||||||||||
cash (received) paid for income taxes | 0 | ||||||||||||||||||||||||||||||||||||||||||||
net cash provided by investing activities | 16,385,000 | ||||||||||||||||||||||||||||||||||||||||||||
non-cash revenue from collaborative arrangements | |||||||||||||||||||||||||||||||||||||||||||||
receivable from theravance, inc. | 14,535,000 | ||||||||||||||||||||||||||||||||||||||||||||
prepaid and other current assets | |||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of ordinary shares to mylan, net of premium | 0 | 0 | 25,753,000 | ||||||||||||||||||||||||||||||||||||||||||
excess tax benefit of share-based compensation | -34,000 | -151,000 | 391,000 | ||||||||||||||||||||||||||||||||||||||||||
repurchase of restricted stock | |||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents contributed from theravance, inc. | 0 | ||||||||||||||||||||||||||||||||||||||||||||
transfers from theravance, inc. | 0 | ||||||||||||||||||||||||||||||||||||||||||||
supplemental disclosure of non-cash information | |||||||||||||||||||||||||||||||||||||||||||||
contribution of net assets, excluding cash and cash equivalents, from theravance, inc. | 0 | ||||||||||||||||||||||||||||||||||||||||||||
depreciation | 595,000 | 586,000 | |||||||||||||||||||||||||||||||||||||||||||
amortization of premium on marketable securities | 152,000 | 239,000 | |||||||||||||||||||||||||||||||||||||||||||
charge to write-down inventory to net realizable value | 0 | 79,000 | |||||||||||||||||||||||||||||||||||||||||||
adjustments to reconcile net loss to net cash used in operating activities: | |||||||||||||||||||||||||||||||||||||||||||||
other non-cash items | |||||||||||||||||||||||||||||||||||||||||||||
deferred rent expense | 81,000 | 98,000 | 117,000 | ||||||||||||||||||||||||||||||||||||||||||
payments received on notes receivable | |||||||||||||||||||||||||||||||||||||||||||||
supplemental disclosure of noncash information | |||||||||||||||||||||||||||||||||||||||||||||
purchases of available-for-sale securities | |||||||||||||||||||||||||||||||||||||||||||||
maturities of available-for-sale securities | |||||||||||||||||||||||||||||||||||||||||||||
stock-based compensation | 12,701,000 | ||||||||||||||||||||||||||||||||||||||||||||
transfers from parent company | 46,419,000 |
