Seagen Inc
(NASDAQ:SGEN)

Seagen Inc., a biotechnology company, develops and commercializes therapies for the treatment of cancer in the United States and internationally. The company markets ADCETRIS, an antibody-drug conjugate (ADC) for the treatment of patients with Hodgkin lymphoma or CD30-positive T-cell lymphomas; PADC...

Website: http://www.seattlegenetics.com

Founded: 1997

Full Time Employees: 1,605

Sector: Healthcare

Industry: Biotechnology

Pharmaceuticals

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Unit: USD	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-12-31	2014-09-30	2014-06-30	2014-03-31	2013-12-31	2013-09-30	2013-06-30	2013-03-31	2012-12-31	2012-09-30	2012-06-30	2012-03-31	2011-12-31	2011-09-30	2011-06-30	2011-03-31	2010-12-31	2010-09-30	2010-06-30	2010-03-31	2009-12-31	2009-09-30	2009-06-30	2009-03-31	2008-12-31	2008-09-30	2008-06-30	2008-03-31	2007-12-31	2007-09-30	2007-06-30	2007-03-31	2006-12-31	2006-09-30	2006-06-30	2006-03-31	2005-12-31	2005-09-30	2005-06-30	2005-03-31	2004-12-31	2004-09-30	2004-06-30	2004-03-31	2003-12-31	2003-09-30	2003-06-30	2003-03-31	2002-12-31	2002-09-30	2002-06-30	2002-03-31	2001-09-30	2001-06-30

revenues:
net product sales	570,729,000	543,974,000	468,639,000	463,627,000	428,089,000	431,714,000	383,086,000	369,181,000	366,459,000	166,414,000	167,582,000	158,980,000	135,001,000	132,127,000	126,976,000	122,443,000	95,357,000	83,721,000	79,177,000	74,343,000	70,321,000	70,785,000	70,117,000	66,216,000	58,648,000	63,012,000	59,059,000	55,095,000	48,886,000	46,491,000	48,209,000	44,782,000	38,716,000	38,524,000	36,485,000	35,736,000	33,920,000	35,355,000	33,658,000	34,691,000	34,496,000	33,194,000	10,047,000
royalty revenues	63,561,000	51,189,000	30,178,000	53,360,000	43,904,000	39,109,000	28,181,000	45,981,000	41,028,000	72,273,000	27,261,000	23,337,000	15,620,000	24,553,000	22,662,000	20,551,000	15,674,000	20,031,000	16,670,000	12,375,000	16,980,000	13,712,000	12,224,000	9,188,000	32,331,000	12,613,000	9,702,000	7,615,000	11,050,000	11,854,000	8,143,000	7,334,000	12,673,000	6,629,000	5,250,000	3,540,000	2,399,000	2,129,000	1,698,000	1,238,000
collaboration and license agreement revenues	14,360,000	8,669,000	20,902,000	11,163,000	38,307,000	26,679,000	15,193,000	14,689,000	16,573,000	51,117,000	18,420,000	36,130,000	44,578,000	17,833,000	19,786,000	27,179,000	29,559,000	25,853,000	39,444,000	21,505,000	21,830,000	20,778,000	23,974,000	19,998,000	20,176,000	17,852,000	15,311,000	14,386,000	22,221,000	15,981,000	19,501,000	16,192,000	16,882,000	22,256,000	29,234,000	34,282,000	21,009,000	26,428,000	14,476,000	12,894,000	13,749,000	15,693,000	10,619,000
total revenues	648,650,000	603,832,000	519,719,000	528,150,000	510,300,000	497,502,000	426,460,000	429,851,000	424,060,000	289,804,000	213,263,000	218,447,000	195,199,000	174,513,000	169,424,000	170,173,000	140,590,000	129,605,000	135,291,000	108,223,000	109,131,000	105,275,000	106,315,000	95,402,000	111,155,000	93,477,000	84,072,000	77,096,000	82,157,000	74,326,000	75,853,000	68,308,000	68,271,000	67,409,000	70,969,000	73,558,000	57,328,000	63,912,000	49,832,000	48,823,000	48,245,000	48,887,000	20,666,000																											1,696,000	1,491,000	1,542,000	1,972,000	1,329,587	1,525,377	1,504,593	710,443	634,285	404,706	375,405	269,272	70,331	34,584
yoy	27.11%	21.37%	21.87%	22.87%	20.34%	71.67%	99.97%	96.78%	117.24%	66.06%	25.88%	28.37%	38.84%	34.65%	25.23%	57.24%	28.83%	23.11%	27.25%	13.44%	-1.82%	12.62%	26.46%	23.74%	35.30%	25.77%	10.84%	12.87%	20.34%	10.26%	6.88%	-7.14%	19.09%	5.47%	42.42%	50.66%	18.83%	30.73%	141.13%																															27.56%	-2.25%	2.49%	177.57%	109.62%	276.91%	300.79%	163.84%	801.86%	1070.21%
qoq	7.42%	16.18%	-1.60%	3.50%	2.57%	16.66%	-0.79%	1.37%	46.33%	35.89%	-2.37%	11.91%	11.85%	3.00%	-0.44%	21.04%	8.48%	-4.20%	25.01%	-0.83%	3.66%	-0.98%	11.44%	-14.17%	18.91%	11.19%	9.05%	-6.16%	10.54%	-2.01%	11.05%	0.05%	1.28%	-5.02%	-3.52%	28.31%	-10.30%	28.25%	2.07%	1.20%	-1.31%	136.56%																												13.75%	-3.31%	-21.81%	48.32%	-12.84%	1.38%	111.78%	12.01%	56.73%	7.81%	39.41%	282.86%	103.36%
costs and expenses:
cost of sales	165,254,000	180,753,000	111,776,000	108,210,000	108,122,000	106,100,000	87,626,000	86,690,000	82,650,000	9,639,000	8,723,000	8,609,000	7,911,000	30,222,000	12,348,000	13,157,000	10,358,000	10,213,000	9,019,000	8,055,000	7,481,000	7,896,000	7,427,000	6,901,000	5,944,000	6,701,000	6,625,000	5,940,000	5,210,000	5,036,000	4,725,000	4,088,000	3,664,000	3,751,000	3,528,000	3,311,000	3,169,000	2,738,000	2,742,000	2,995,000	3,071,000	2,391,000	724,000
research and development	449,047,000	399,868,000	356,015,000	357,843,000	384,605,000	304,254,000	297,659,000	304,294,000	459,092,000	201,061,000	196,119,000	163,929,000	158,265,000	149,772,000	140,175,000	122,860,000	152,502,000	110,504,000	113,606,000	114,406,000	118,184,000	108,172,000	92,711,000	85,554,000	92,871,000	74,607,000	70,790,000	85,737,000	63,395,000	64,043,000	58,510,000	53,694,000	54,496,000	50,772,000	67,847,000	52,273,000	47,735,000	47,663,000	41,392,000	42,755,000	38,487,000	40,239,000	41,080,000	49,643,000	32,434,000	32,520,000	44,287,000	39,287,000	30,316,000	28,918,000	28,263,000	28,712,000	33,246,000	37,582,000	27,711,000	23,499,000	22,152,000	20,109,000	17,735,000	15,179,000	11,805,000	11,081,000	9,797,000	10,007,000	9,251,000	8,537,000	7,806,000	9,365,000	8,975,000	10,993,000	9,578,000	9,014,000	7,572,000	5,119,694	5,479,212	5,633,662	5,527,432	5,356,063	4,296,664	5,314,607	4,852,896	5,093,631	3,519,105
selling, general and administrative	265,687,000	243,932,000	236,441,000	216,101,000	210,378,000	220,259,000	174,225,000	210,937,000	180,281,000	115,229,000	96,101,000	82,331,000	80,271,000	79,467,000	57,155,000	58,292,000	66,182,000	48,450,000	39,667,000	40,712,000	38,404,000	41,377,000	34,841,000	33,282,000	29,747,000	33,635,000	29,684,000	30,343,000	32,121,000	29,435,000	25,342,000	25,525,000	24,018,000	25,481,000	21,451,000	23,536,000	21,886,000	23,411,000	18,842,000	19,862,000	22,185,000	24,954,000	19,795,000
total costs and expenses	879,988,000	824,553,000	704,232,000	682,154,000	703,105,000	630,613,000	559,510,000	601,921,000	722,023,000	328,218,000	303,047,000	257,157,000	248,836,000	264,824,000	214,998,000	200,457,000	234,419,000	174,617,000	167,488,000	167,497,000	168,449,000	161,124,000	138,727,000	128,844,000	132,177,000	118,621,000	110,572,000	124,659,000	103,900,000	102,050,000	91,478,000	85,951,000	84,642,000	83,090,000	94,753,000	80,567,000	73,715,000	74,620,000	63,589,000	66,114,000	63,743,000	67,584,000	61,599,000
income from operations	-231,338,000	-220,721,000	-184,513,000	-154,004,000	-192,805,000	-133,111,000	-133,050,000	-172,070,000	-297,963,000	-38,414,000	-89,784,000	-38,710,000	-53,637,000	-90,311,000	-45,574,000	-30,284,000	-93,829,000	-45,012,000	-32,197,000	-59,274,000	-59,318,000	-55,849,000	-32,412,000	-33,442,000	-21,022,000	-25,144,000	-26,500,000	-47,563,000	-21,743,000	-27,724,000	-15,625,000	-17,643,000	-16,371,000	-15,681,000	-23,784,000	-7,009,000	-16,387,000	-10,708,000	-13,757,000	-17,291,000	-15,498,000	-18,697,000	-40,933,000	-51,786,000	-32,976,000	-34,896,000	-35,334,000	-8,876,000	10,908,000	-12,701,000	-20,573,000	-23,323,000	-28,260,000	-31,876,000	-23,319,000	-17,589,000	-19,002,000	-16,579,000	-16,395,000	-12,382,000	-10,289,000	-11,244,000	-9,975,000	-9,569,000	-9,417,000	-7,997,000	-6,838,000	-9,022,000	-8,214,000	-11,186,000	-9,882,000	-9,392,000	-7,208,000	-5,733,501	-5,484,452	-5,745,840	-6,299,207
yoy	19.99%	65.82%	38.68%	-10.50%	-35.29%	246.52%	48.19%	344.51%	455.52%	-57.46%	97.01%	27.82%	-42.84%	100.64%	41.55%	-48.91%	58.18%	-19.40%	-0.66%	77.24%	182.17%	122.12%	22.31%	-29.69%	-3.32%	-9.31%	69.60%	169.59%	32.81%	76.80%	-34.30%	151.72%	-0.10%	46.44%	72.89%	-59.46%	5.74%	-42.73%	-66.39%	-66.61%	-53.00%	-46.42%	15.85%	483.44%	-402.31%	174.75%	71.75%	-61.94%	-138.60%	-60.15%	-11.78%	32.60%	48.72%	92.27%	42.23%	42.05%	84.68%	47.45%	64.36%	29.40%	9.26%	40.60%	45.88%	6.06%	14.65%	-28.51%	-30.80%	-3.94%	13.96%	95.10%	80.18%	63.46%	14.43%
qoq	4.81%	19.62%	19.81%	-20.12%	44.85%	0.05%	-22.68%	-42.25%	675.66%	-57.22%	131.94%	-27.83%	-40.61%	98.16%	50.49%	-67.72%	108.45%	39.80%	-45.68%	-0.07%	6.21%	72.31%	-3.08%	59.08%	-16.39%	-5.12%	-44.28%	118.75%	-21.57%	77.43%	-11.44%	7.77%	4.40%	-34.07%	239.34%	-57.23%	53.04%	-22.16%	-20.44%	11.57%	-17.11%	-54.32%	-20.96%	57.04%	-5.50%	-1.24%	298.08%	-181.37%	-185.88%	-38.26%	-11.79%	-17.47%	-11.34%	36.70%	32.58%	-7.44%	14.61%	1.12%	32.41%	20.34%	-8.49%	12.72%	4.24%	1.61%	17.76%	16.95%	-24.21%	9.84%	-26.57%	13.20%	5.22%	30.30%	25.72%	4.54%	-4.55%	-8.78%
operating margin %	-35.66%	-36.55%	-35.50%	-29.16%	-37.78%	-26.76%	-31.20%	-40.03%	-70.26%	-13.26%	-42.10%	-17.72%	-27.48%	-51.75%	-26.90%	-17.80%	-66.74%	-34.73%	-23.80%	-54.77%	-54.35%	-53.05%	-30.49%	-35.05%	-18.91%	-26.90%	-31.52%	-61.69%	-26.47%	-37.30%	-20.60%	-25.83%	-23.98%	-23.26%	-33.51%	-9.53%	-28.58%	-16.75%	-27.61%	-35.42%	-32.12%	-38.25%	-198.07%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-659.55%	-662.78%	-609.08%	-365.52%	-431.22%	-359.55%	-381.89%	-886.66%	0%	0%	0%	0%	0%	0%
investment and other income	14,978,000	12,084,000	14,400,000	10,176,000	4,278,000			-4,904,000	5,228,000	64,244,000	-2,129,000	-40,528,000	40,308,000	-53,147,000	-21,872,000	106,557,000		-47,546,000	82,218,000	2,914,000	-672,000					288,000	62,000	61,000	53,000	1,040,000	59,000	53,000	70,000	10,000	98,000	110,000	123,000	112,000	105,000	55,000	3,200,000
income before income taxes	-216,360,000	-208,637,000	-170,113,000	-143,828,000	-188,527,000	-134,720,000	-135,240,000	-176,974,000	-292,735,000
benefit for income taxes	-571,000
net income	-215,789,000	-211,528,000	-174,737,000	-148,171,000	-190,816,000	-134,827,000	-136,494,000	-174,628,000	-293,847,000	25,830,000	-91,913,000	-79,238,000	-13,329,000	-119,805,000	-67,446,000	76,273,000	-111,715,000	-59,201,000	50,021,000	-56,360,000	-59,990,000	-55,138,000	-31,752,000	-32,743,000	-20,478,000	-24,856,000	-26,438,000	-47,502,000	-21,690,000	-26,684,000	-15,566,000	-17,590,000	-16,301,000	-15,671,000	-23,686,000	-6,899,000	-16,264,000	-10,596,000	-13,652,000	-17,236,000	-12,298,000	-27,165,000	-40,685,000	-51,506,000	-32,674,000	-34,546,000	-34,856,000	-8,323,000	11,460,000	-12,117,000	-19,827,000	-22,471,000	-27,268,000	-30,597,000	-21,764,000	-16,028,000	-17,112,000	-14,941,000	-14,613,000	-10,550,000	-8,828,000	-10,020,000	-8,649,000	-8,643,000	-8,703,000	-7,349,000	-6,171,000	-8,360,000	-7,553,000	-10,570,000	-9,368,000	-8,836,000	-6,665,000	-5,436,168	-5,183,399	-5,504,827	-5,961,606
yoy	13.09%	56.89%	28.02%	-15.15%	-35.06%	-621.98%	48.50%	120.38%	2104.57%	-121.56%	36.28%	-203.89%	-88.07%	102.37%	-234.84%	-235.33%	86.22%	7.37%	-257.54%	72.13%	192.95%	121.83%	20.10%	-31.07%	-5.59%	-6.85%	69.84%	170.05%	33.06%	70.28%	-34.28%	154.96%	0.23%	47.90%	73.50%	-59.97%	32.25%	-60.99%	-66.44%	-66.54%	-62.36%	-21.37%	16.72%	518.84%	-385.11%	185.10%	75.80%	-62.96%	-142.03%	-60.40%	-8.90%	40.20%	59.35%	104.79%	48.94%	51.92%	93.84%	49.11%	68.96%	22.06%	1.44%	36.35%	40.16%	3.39%	15.23%	-30.47%	-34.13%	-5.39%	13.32%	94.44%	80.73%	60.51%	11.80%
qoq	2.01%	21.06%	17.93%	-22.35%	41.53%	-1.22%	-21.84%	-40.57%	-1237.62%	-128.10%	16.00%	494.48%	-88.87%	77.63%	-188.43%	-168.27%	88.70%	-218.35%	-188.75%	-6.05%	8.80%	73.65%	-3.03%	59.89%	-17.61%	-5.98%	-44.34%	119.00%	-18.72%	71.42%	-11.51%	7.91%	4.02%	-33.84%	243.33%	-57.58%	53.49%	-22.38%	-20.79%	40.15%	-54.73%	-33.23%	-21.01%	57.64%	-5.42%	-0.89%	318.79%	-172.63%	-194.58%	-38.89%	-11.77%	-17.59%	-10.88%	40.59%	35.79%	-6.33%	14.53%	2.24%	38.51%	19.51%	-11.90%	15.85%	0.07%	-0.69%	18.42%	19.09%	-26.18%	10.68%	-28.54%	12.83%	6.02%	32.57%	22.60%	4.88%	-5.84%	-7.66%
net income margin %	-33.27%	-35.03%	-33.62%	-28.05%	-37.39%	-27.10%	-32.01%	-40.63%	-69.29%	8.91%	-43.10%	-36.27%	-6.83%	-68.65%	-39.81%	44.82%	-79.46%	-45.68%	36.97%	-52.08%	-54.97%	-52.38%	-29.87%	-34.32%	-18.42%	-26.59%	-31.45%	-61.61%	-26.40%	-35.90%	-20.52%	-25.75%	-23.88%	-23.25%	-33.38%	-9.38%	-28.37%	-16.58%	-27.40%	-35.30%	-25.49%	-55.57%	-196.87%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-623.23%	-628.30%	-573.02%	-337.98%	-408.86%	-339.81%	-365.87%	-839.14%	0%	0%	0%	0%	0%	0%
net income per share	-1.15	-1.13	-0.93	-0.79	-1.03	-0.73	-0.74	-0.95	-1.61	0.17	-0.55	-0.49	-0.08	-0.75	-0.42	0.48	-0.73	-0.42	0.35	-0.39	-0.42	-0.39	-0.23	-0.23	-0.15	-0.17	-0.21	-0.38	-0.17	-0.22	-0.13	-0.14	-0.13	-0.12	-0.19	-0.06	-0.14	-0.09	-0.12	-0.15	-0.11	-0.23	-0.35	-0.45	-0.3	-0.35	-0.34	-0.08	0.11	-0.11	-0.21	-0.26	-0.33	-0.39	-0.27	-0.2	-0.22	-0.23	-0.22	-0.18	-0.16	-0.2	-0.17	-0.17	-0.21	-0.18	-0.15	-0.2	-0.18	-0.24	-0.4	-0.89	-0.24
shares used in computation of per share amounts - basic and diluted	188,135	187,559	186,889	46,049.75	184,792	184,145	183,647			2,070	168,109		160,657
comprehensive loss:
other comprehensive income:
unrealized gain on securities available-for-sale, net of tax	97	172	1,370	-1,118	-875		-861	-2.5	37	74.25	-177	252	222							4,435
foreign currency translation gain	189	228	-1,172	1,572	3,363	2,819	106	67	-6	20	-7	18	34	-40	13	-15		-5	14	4	-2	-3	-7	6	8
total other comprehensive income	286	400	198	515	2,488	83		356	31	-73	-184	270	256	265	-131	90	19				3,980	-278	-153			8.75	-6
comprehensive loss	-215,503	-211,128	-174,539	-115,080.25	-188,328	-134,744	-137,249			25,757	-92,097		-13,073				-111,696			-51,921	-56,010	-55,416	-31,905	-32,485	-19,685	-25,545	-26,444	-47,479	-21,672	-27,214	-15,821	-16,843	-16,281	-15,729	-23,639	-6,926	-16,274	-10,572	-13,602	-17,238	-12,353
benefit from income taxes		2,891,000	4,624,000	912,500	2,289,000	107,000	1,254,000	278,000	1,112,000
investment and other income						-1,609,000	-2,190,000
unrealized loss on securities available-for-sale, net of tax						-2,736
other comprehensive loss:
total other comprehensive loss							-755
shares used in computation of per share amounts - basic								352	182,303			161,436		39,199.75	159,304	158,381
shares used in computation of per share amounts - diluted								352	182,303			161,436		39,199.75	159,304	163,382
comprehensive income:
comprehensive income								-174,272	-293,816			-78,968		-25,727.5	-67,577	76,363		-12,067.25	59,662
cost of royalty revenues										2,289,000	2,104,000	2,288,000	2,389,000	5,363,000	5,320,000	6,148,000	5,377,000	5,450,000	5,196,000	4,324,000	4,380,000	3,679,000	3,748,000	3,107,000	3,615,000	3,678,000	3,473,000	2,639,000	3,174,000	3,536,000	2,901,000	2,644,000	2,464,000	3,086,000	1,927,000	1,447,000	925,000	808,000	613,000	502,000
unrealized gain on securities available-for-sale, net of tax of 0, 5,915, 0, and 11,087, respectively														-3	-144
unrealized gain on securities available for sale, net of tax																105	27				3,982
revenues
costs and expenses
investment and other loss																	-17,886,000
shares used in computation of per share amounts—basic and diluted																	152,049
foreign currency translation loss																	-8									-3	-9
shares used in computation of net income per share—basic																		35,719	143,357
shares used in computation of net income per share—diluted																		35,719	148,068
unrealized gain on securities available-for-sale, net of tax of 5,915, 0, 11,087, and 0, respectively																		4,511	9,627
shares used in computation of net income per share—basic and diluted																				142,802	142,458	377	140,928	140,283	139,890	3,491	127,667	125,064	124,312	174	123,591	123,209	122,896	30,315	121,990	121,317	120,455	29,340.25	118,471
investment income																						475,750	660,000	699,000	544,000																	-8,468,000	248,000	280,000	302,000	350,000	478,000	553,000	552,000	584,000	746,000	852,000	992,000	1,279,000	1,555,000	1,561,000	1,890,000	1,638,000	1,782,000	1,832,000	1,461,000	1,224,000	1,326,000	926,000	714,000	648,000	667,000	662,000	661,000	616,000	514,000	556,000	543,000	297,333	301,053	241,013	337,601	416,903	485,941	555,679	576,627	800,372	886,068
unrealized gain on securities available for sale																						-275	-146	252	785	11	3														-55
other comprehensive gain —unrealized gain on securities available for sale																												23
other comprehensive gain—unrealized gain on securities available for sale																													18	-530	-255	747	20	-58	47			24	50
other comprehensive loss—unrealized loss on securities available for sale																																				-27	-10
shares used in computation of net income per share - basic and diluted																																								117,252	116,348																					11,965.5	50,997	50,077	42,418
other comprehensive loss - unrealized gain on securities available for sale																																								-2
weighted-average shares used for eps calculation																																											114,727				101,221																												30,708,938	30,618,987	30,549,829	30,138,023	30,395,760	30,184,006	29,508,376	28,781,416	28,625,420
revenue from collaboration and license agreements																																												13,054,000
operating expenses
general and administrative																																												15,197,000	12,713,000	10,522,000	7,038,000	6,467,000	5,231,000	5,552,000	3,956,000	4,019,000	4,156,000	4,362,000	3,687,000	4,094,000	3,935,000	4,306,000	3,297,000	2,814,000	2,820,000	2,746,000	2,619,000	2,402,000	2,307,000	1,779,000	1,664,000	1,857,000	1,845,000	1,809,000	1,692,000	1,387,000	1,455,000	1,602,231	1,191,964	1,125,978	1,137,827	984,718	1,093,313	1,054,793	1,105,412	787,105	832,179
total operating expenses																																												64,840,000	45,147,000	43,042,000	51,325,000	45,754,000	35,547,000	34,470,000	32,219,000	32,731,000	37,402,000	41,944,000	31,398,000	27,593,000	26,087,000	24,415,000	21,032,000	17,993,000	14,625,000	13,827,000	12,416,000	12,409,000	11,558,000	10,316,000	9,470,000	11,222,000	10,820,000	12,882,000	11,373,000	10,934,000	9,180,000	7,063,088	7,009,829	7,250,433	7,009,650	6,865,569	5,978,783	7,197,169	6,837,835	7,106,406	6,030,995
revenues from collaboration and license agreements																																													12,171,000	8,146,000	15,991,000	36,878,000	46,455,000	21,769,000	11,646,000	9,408,000	9,142,000	10,068,000	8,079,000	10,004,000	7,085,000	7,836,000	4,637,000	5,611,000	4,336,000
shares used in computation of net income per share – basic and diluted																																																		21,942.75	93,460	86,200	83,545	19,592.25	79,559	79,277	76,258	14,807	65,957	57,064	54,539
collaboration and license agreements																																																														1,855,500	2,441,000	2,840,000	2,141,000			2,200,000	2,606,000	1,696,000	1,491,000	1,542,000	1,972,000	1,317,597	1,503,592	1,488,918	678,893	597,741	392,728	332,357	219,819
revenue under collaboration and license agreements																																																																		1,859,500	2,632,000
operating expenses:
non-cash accretion of preferred stock deemed dividend																																																																							-7,229,000	-27,085,000	-2,244,000	-186,297	-14,703
net income attributable to common stockholders																																																																		-7,349,000	-6,171,000	-8,360,000	-7,553,000	-10,570,000	-16,597,000	-35,921,000	-8,909,000	-5,622,465	-5,198,102			-5,814,381	-5,088,136	-6,266,085	-5,991,936	-6,235,703	-5,110,343
weighted-average shares – basic and diluted																																																																			42,317	42,187			41,221
weighted-average shares - basic and diluted																																																																					42,067			40,192	36,548	30,722
government grants																																																																										11,990	21,785	15,675	31,550	36,544	11,978	43,048	49,453	11,024
non-cash stock-based compensation expense																																																																						80,000	103,000	533,000	153,000	341,163	338,653	490,793		524,788	588,806	827,769	879,527	1,225,670	1,679,711
basic and diluted net income per share attributable to common stockholders																																																																										-0.135	-0.17
basic and diluted net income per share																																																																												-0.18	-0.2	-0.19	-0.17	-0.21	-0.2	-0.22	-0.18
non-cash stock-based compensation																																																																													344,391
accretion on mandatorily redeemable preferred stock
license agreements																																																																																		59,307	34,584
expenses
deemed dividend upon issuance of series b mandatorily redeemable preferred stock
the accompanying notes are an integral part of these financial statements

Balance Sheets:

Quarterly

Annual

Unit: USD	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-12-31	2014-09-30	2014-06-30	2014-03-31	2013-12-31	2013-09-30	2013-06-30	2013-03-31	2012-12-31	2012-09-30	2012-06-30	2012-03-31	2011-12-31	2011-09-30	2011-06-30	2011-03-31	2010-12-31	2010-09-30	2010-06-30	2010-03-31	2009-12-31	2009-09-30	2009-06-30	2009-03-31	2008-12-31	2008-09-30	2008-06-30	2008-03-31	2007-12-31	2007-09-30	2007-06-30	2007-03-31	2006-12-31	2006-09-30	2006-06-30	2006-03-31	2005-12-31	2005-09-30	2005-06-30	2005-03-31	2004-12-31	2004-09-30	2004-06-30	2004-03-31	2003-12-31	2003-09-30	2003-06-30	2003-03-31	2002-12-31	2002-09-30	2002-06-30	2002-03-31	2001-09-30	2001-06-30

assets
current assets:
cash and cash equivalents	428,568,000	308,441,000	335,847,000	319,940,000	362,601,000	364,874,000	260,996,000	424,834,000	685,173,000	274,562,000	193,466,000	64,112,000	84,270,000	78,186,000	115,457,000	159,287,000	186,890,000	160,945,000	128,140,000	197,104,000	75,767,000	108,673,000	131,029,000	192,088,000	119,547,000	102,255,000	614,074,000	79,013,000	62,571,000	56,927,000	50,168,000	38,831,000	44,812,000	64,116,000	119,529,000	27,632,000	34,934,000	54,663,000	54,931,000	60,760,000	53,343,000	87,634,000	112,105,000	79,797,000	61,469,000	21,127,000	22,771,000	49,493,000	18,332,000	18,486,000	72,060,000	26,591,000	30,741,000	30,800,000	24,413,000	34,908,000	115,123,000	59,644,000	13,399,000	5,075,000	17,508,000	9,137,000	27,911,000	35,165,000	11,709,000	11,156,000	10,906,000	14,230,000	10,403,000	9,645,000	14,960,000	18,502,000	16,886,000	9,625,000	8,031,905	8,628,196	10,452,933	9,180,916	8,895,913	4,124,998	6,349,334	5,169,624	4,330,636
short-term investments	808,418,000	983,678,000	1,154,425,000	1,415,130,000	1,401,101,000	1,485,448,000	1,690,097,000	1,735,202,000	1,751,201,000	536,493,000	676,847,000	312,017,000	334,025,000	332,486,000	347,619,000	288,690,000	213,026,000	252,226,000	322,258,000	255,307,000	430,637,000	480,313,000	460,766,000	416,857,000	489,943,000	547,396,000	122,380,000	170,523,000	233,442,000	256,486,000	289,393,000	310,378,000	310,546,000	310,151,000	254,319,000	310,457,000	309,200,000	309,595,000	259,003,000	269,577,000	255,524,000	243,062,000	249,592,000	331,322,000	381,128,000	260,682,000	280,142,000	263,874,000	299,954,000	242,319,000	194,417,000	114,037,000	100,866,000	64,379,000	80,113,000	78,603,000	52,296,000	51,717,000	78,528,000	88,426,000	91,059,000	73,450,000	58,964,000	61,908,000	24,530,000	31,315,000	30,527,000	29,900,000	33,403,000	27,492,000	25,394,000	25,569,000	33,764,000	31,205,000	25,091,558	5,039,849	11,121,946	17,198,934	22,001,068	31,520,452	39,633,659	30,601,054	39,292,504
accounts receivable	631,555,000	586,048,000	495,777,000	501,912,000	486,755,000	438,041,000	401,009,000	389,256,000	387,169,000	236,001,000	190,318,000	182,264,000	156,955,000	146,281,000	152,520,000	149,976,000	118,579,000	84,774,000	90,432,000	71,940,000	73,687,000	61,928,000	65,121,000	57,742,000	52,392,000	52,930,000	63,498,000	45,250,000	49,587,000	39,248,000	43,817,000	34,905,000	37,896,000	29,508,000	29,208,000	47,669,000	44,721,000	33,443,000	35,156,000	31,553,000	56,581,000	54,955,000	15,447,000	11,011,000	8,621,000	19,279,000	15,262,000	15,180,000	13,815,000	80,122,000	3,994,000	6,017,000	11,880,000	8,186,000	6,595,000	7,592,000	7,365,000	5,988,000	5,388,000	4,985,000	3,733,000	898,000	734,000	759,000	357,000	683,000	872,000	642,000	908,000	1,477,000	647,000	705,000	1,171,000	826,000	1,031,871	1,119,901	308,525	372,036	128,085	140,806	51,576
inventories	531,188,000	486,854,000	477,694,000	427,211,000	364,970,000	319,354,000	275,747,000	200,663,000	181,375,000	85,932,000	92,034,000	73,150,000	67,236,000	53,239,000	75,172,000	70,933,000	71,915,000	59,978,000	60,837,000	69,247,000	60,723,000	68,124,000	71,645,000	71,675,000	60,050,000	56,963,000	44,515,000	47,489,000	43,069,000	43,451,000	37,541,000	30,491,000	29,044,000	27,073,000	26,004,000	38,661,000	33,732,000	37,747,000	34,296,000	25,697,000	15,753,000	9,469,000	3,428,000
prepaid expenses and other current assets	151,864,000	150,675,000	138,168,000	138,340,000	144,192,000	170,938,000	143,406,000	119,239,000	109,695,000	43,653,000	43,694,000	40,398,000	37,306,000	43,403,000	26,180,000	36,935,000	44,126,000	19,138,000	18,905,000	22,411,000	15,417,000	15,610,000	15,743,000	12,220,000	14,211,000	11,515,000	8,303,000	11,847,000	8,247,000	11,874,000	8,269,000	8,410,000	7,052,000	5,817,000	5,700,000	6,343,000	7,191,000	4,519,000	4,696,000	6,626,000	5,320,000	3,820,000	5,325,000	4,363,000	2,673,000		3,441,000	3,447,000	7,528,000		2,046,000	1,762,000	2,000,000		6,753,000																				647,477	1,008,902	725,198	320,443	717,237	700,870	874,302
total current assets	2,551,593,000	2,515,696,000	2,601,911,000	2,802,533,000	2,759,619,000	2,778,655,000	2,771,255,000	2,869,194,000	3,114,613,000	1,176,641,000	1,196,359,000	671,941,000	679,792,000	653,595,000	716,948,000	705,821,000	634,536,000	577,061,000	620,572,000	616,009,000	656,231,000	734,648,000	744,304,000	750,582,000	736,143,000	771,059,000	852,770,000	354,122,000	396,916,000	407,986,000	429,188,000	423,015,000	429,350,000	437,256,000	434,980,000	431,375,000	430,939,000	440,860,000	389,578,000	395,092,000	387,358,000	399,581,000	386,911,000	427,685,000	455,119,000	304,116,000	322,668,000	333,153,000	342,021,000	348,579,000	273,886,000	150,392,000	147,514,000	110,716,000	119,943,000	129,986,000	177,743,000	119,351,000	100,135,000	101,584,000	114,311,000	85,429,000	89,407,000	100,251,000	38,006,000	44,146,000	43,588,000	46,318,000	45,913,000	39,908,000	43,384,000	48,484,000	53,519,000	42,671,000	35,348,022	15,974,040	22,892,318	27,443,632	32,236,309	37,167,475	47,645,806	37,310,352	46,980,402
property and equipment	358,801,000	307,518,000	263,997,000	248,179,000	230,302,000	218,901,000	214,379,000	210,073,000	209,469,000	155,491,000	144,743,000	130,900,000	114,604,000	103,820,000	100,966,000	100,726,000	103,489,000	103,756,000	82,769,000	85,170,000	67,980,000	62,870,000	54,715,000	51,052,000	49,882,000	49,598,000	44,679,000	43,637,000	44,922,000	46,129,000	43,958,000	41,256,000	41,047,000	40,787,000	37,229,000	29,684,000	29,469,000	24,752,000	20,348,000	19,339,000	19,406,000	19,652,000	14,638,000	12,125,000	11,739,000	12,311,000	12,834,000	12,893,000	12,562,000	12,325,000	12,465,000	12,644,000	12,144,000	10,996,000	11,013,000	10,674,000	10,368,000	10,294,000	8,241,000	7,984,000	8,087,000	7,794,000	7,864,000	8,018,000	8,094,000	8,532,000	8,915,000	8,911,000	9,306,000	9,463,000	9,685,000	8,919,000	6,720,000	5,500,000	5,595,741	5,819,791	6,042,376	6,236,270	6,282,352	6,205,248	6,244,899	5,808,906	1,803,576
operating lease right-of-use assets	128,861,000	120,628,000	114,960,000	46,738,000	49,308,000	51,942,000	54,937,000	57,889,000	59,653,000	65,230,000	66,632,000	69,056,000	59,341,000
intangible assets	220,255,000	226,072,000	231,826,000	237,516,000	243,332,000	249,149,000	254,902,000	260,593,000	266,409,000
goodwill	274,671,000	274,671,000	274,671,000	274,671,000	274,671,000	274,671,000	274,671,000	274,671,000	274,671,000	274,671,000	274,671,000	274,671,000	274,671,000	274,671,000	251,017,000	251,017,000	251,017,000
other non-current assets	100,080,000	50,797,000	55,931,000	64,895,000	61,846,000	57,025,000	46,549,000	47,184,000	53,063,000	176,550,000	115,132,000	120,997,000	164,196,000	122,049,000	176,279,000	213,496,000	184,585,000	197,132,000	129,775,000	35,720,000	29,857,000	10,890,000	10,799,000	11,111,000	11,170,000	11,378,000	9,891,000	10,056,000	4,635,000	4,850,000	5,102,000	5,344,000	5,675,000	5,855,000	5,421,000	5,532,000	5,620,000	5,810,000	5,404,000	5,598,000	5,791,000	5,983,000	6,150,000	681,000	479,000	478,000	478,000	478,000	475,000	504,000	531,000	476,000	476,000	476,000	476,000	667,000	665,000	662,000	668,000	486,000	492,000
total assets	3,634,261,000	3,495,382,000	3,543,296,000	3,674,532,000	3,619,078,000	3,630,343,000	3,616,693,000	3,719,604,000	3,977,878,000	2,205,866,000	2,097,537,000	1,567,565,000	1,592,604,000	1,503,329,000	1,567,845,000	1,580,917,000	1,473,627,000	877,949,000	853,083,000	757,471,000	784,048,000	838,396,000	849,912,000	863,286,000	879,386,000	895,095,000	907,340,000	407,815,000	446,473,000	458,965,000	478,248,000	469,615,000	476,072,000	483,898,000	477,630,000	466,591,000	466,028,000	471,422,000	415,330,000	420,029,000	412,555,000	425,216,000	420,490,000	453,635,000	480,593,000	329,936,000	348,716,000	358,452,000	367,910,000	388,333,000	326,421,000	212,821,000	220,940,000	187,717,000	214,000,000	225,675,000	237,414,000	148,530,000	141,345,000	148,767,000	154,582,000	97,695,000	107,261,000	115,740,000	80,917,000	90,019,000	98,457,000	106,556,000	111,974,000	119,109,000	126,053,000	134,664,000	142,240,000	81,999,000	78,056,611	41,272,626	46,895,976	52,535,688	57,981,894	61,776,891	61,114,227	68,013,961	73,445,717
liabilities and stockholders’ equity
current liabilities:
accounts payable	224,813,000	114,415,000	141,475,000	207,851,000	144,499,000	128,872,000	87,228,000	114,824,000	109,957,000	52,292,000	57,901,000	36,877,000	38,772,000	44,179,000																																																																	561,395	604,362	1,339,987	780,291	1,847,346
accrued liabilities and other	729,903,000	648,483,000	571,753,000	610,553,000	581,499,000	479,649,000	444,066,000	454,030,000	588,477,000	207,065,000	181,282,000	168,073,000	142,187,000
total current liabilities	954,716,000	762,898,000	713,228,000	818,404,000	725,998,000	608,521,000	531,294,000	568,854,000	698,434,000	259,357,000	246,211,000	221,952,000	207,869,000	225,072,000	193,652,000	180,847,000	168,022,000	167,129,000	152,789,000	137,779,000	128,895,000	148,516,000	125,808,000	127,714,000	122,710,000	134,266,000	128,261,000	133,760,000	128,152,000	125,893,000	119,129,000	103,841,000	99,029,000	99,198,000	99,637,000	90,348,000	88,987,000	100,577,000	74,536,000	84,644,000	74,025,000	91,140,000	73,923,000	69,514,000	59,817,000	54,821,000	51,183,000	44,804,000	63,036,000	104,498,000	49,812,000	46,817,000	44,735,000	40,220,000	38,043,000	32,462,000	30,098,000	29,348,000	22,718,000	20,832,000	18,963,000	8,549,000	9,353,000	10,204,000	10,541,000	11,098,000	11,089,000	12,272,000	10,354,000	9,675,000	7,298,000	8,269,000	7,720,000	3,832,000	4,085,084	3,166,370	3,674,045	3,492,048	3,483,064	2,747,789	2,381,594	3,045,842	3,978,459
long-term liabilities:
operating lease liabilities, long-term	113,487,000	97,242,000	91,125,000	43,474,000	46,703,000	50,205,000	53,552,000	56,665,000	58,878,000	67,607,000	69,311,000	71,430,000	61,026,000
other long-term liabilities	15,637,000	16,183,000	15,787,000	8,835,000	24,566,000	38,805,000	33,380,000	28,946,000	55,611,000	2,615,000	2,414,000	2,357,000	10,298,000	4,314,000	3,668,000	3,055,000
total long-term liabilities	129,124,000	113,425,000	106,912,000	52,309,000	71,269,000	89,010,000	86,932,000	85,611,000	114,489,000	70,222,000	71,725,000	73,787,000	71,324,000	4,314,000	9,672,000	17,631,000	26,268,000	33,251,000	40,586,000	46,160,000	51,776,000	55,793,000	61,814,000	67,048,000	72,570,000	74,918,000	82,841,000	94,437,000	109,032,000	122,238,000	133,933,000	139,944,000	146,049,000	154,515,000	143,613,000	139,128,000	143,775,000	144,697,000	118,218,000	116,868,000	118,349,000	115,227,000	115,323,000	120,093,000	115,947,000	113,597,000	107,746,000	95,092,000	82,746,000	77,635,000	61,062,000	65,914,000	68,714,000	68,479,000	70,149,000	69,092,000	69,254,000	65,196,000	53,958,000	53,476,000	54,039,000	912,000	1,165,000	1,723,000	2,403,000	3,463,000		5,773,000	4,772,000	5,601,000	5,241,000	4,511,000	3,724,000	3,289,000	1,826,040	1,955,927	2,136,408	2,342,185	2,497,086	2,569,202	318,209	297,284	286,821
commitments and contingencies
stockholders’ equity:
preferred stock, 0.001 par value...																																																																							2,000	2,000	2,000		1,640
common stock, 0.001 par value...	189,000	188,000	187,000	187,000	185,000	184,000	184,000	183,000	183,000	172,000	171,000	162,000	161,000	160,000	160,000	159,000	158,000	144,000	144,000	143,000	143,000	142,000	142,000	140,000	140,000	140,000	139,000	125,000	125,000	124,000	124,000	123,000	123,000	123,000	122,000	121,000	121,000	120,000	119,000	118,000	117,000	116,000	115,000	114,000	114,000	102,000	101,000	101,000	101,000	101,000	101,000	87,000	86,000	80,000	80,000	79,000	79,000	68,000	67,000	57,000	57,000	51,000	51,000	51,000	42,000	42,000	42,000	42,000	42,000	42,000	42,000	40,000	40,000	32,000	30,919	30,794	30,771	30,693	30,688	30,660	29,928	29,301	29,287
additional paid-in capital	5,302,239,000	5,155,375,000	5,048,345,000	4,954,469,000	4,824,807,000	4,747,481,000	4,678,392,000	4,607,816,000	4,533,360,000	3,359,124,000	3,288,196,000	2,688,333,000	2,650,951,000	2,598,411,000	2,569,449,000	2,519,791,000	2,493,053,000	1,806,159,000	1,774,936,000	1,748,423,000	1,726,347,000	1,701,048,000	1,673,835,000	1,648,166,000	1,631,263,000	1,613,383,000	1,598,166,000	1,055,116,000	1,037,308,000	1,017,182,000	1,004,320,000	989,144,000	977,465,000	960,375,000	948,842,000	927,939,000	917,164,000	893,773,000	879,630,000	861,970,000	846,397,000	832,713,000	819,581,000	811,268,000	800,523,000	624,759,000	618,648,000	613,314,000	607,277,000	603,053,000	599,507,000	464,818,000	450,271,000	394,338,000	391,256,000	386,329,000	383,316,000	282,324,000	278,131,000	273,504,000	270,052,000	267,807,000	266,274,000	264,800,000	220,402,000	219,159,000	219,128,000	218,668,000	218,606,000	217,995,000	217,087,000	216,782,000	216,728,000	154,497,000	146,203,290	105,376,164	105,217,220	105,229,281	105,254,363	105,414,987	101,925,824	98,497,221	98,499,735
accumulated other comprehensive income	4,394,000	4,108,000	3,708,000	3,510,000	2,995,000	507,000	424,000	1,179,000	823,000	229,000	302,000	486,000	216,000	-40,000	-305,000	-174,000	-264,000	63,836,000	17,997,000	8,356,000	3,917,000		215,000	368,000	110,000		6,000	12,000			501,000	756,000	9,000	-11,000	47,000		27,000	37,000	13,000	-37,000	-35,000													-1,378,000																-65,000	-17,000	-613,000	93,000	39,000	-15,301	205,997	221,734	294,961	307,155	335,577	356,769	618,891	191,895
accumulated deficit	-2,756,401,000	-2,540,612,000	-2,329,084,000	-2,154,347,000	-2,006,176,000	-1,815,360,000	-1,680,533,000	-1,544,039,000	-1,369,411,000	-1,483,238,000	-1,509,068,000	-1,417,155,000	-1,337,917,000	-1,324,588,000	-1,204,783,000	-1,137,337,000	-1,213,610,000	-1,192,570,000	-1,133,369,000	-1,183,390,000	-1,127,030,000	-1,067,040,000	-1,011,902,000	-980,150,000	-947,407,000	-926,929,000	-902,073,000	-875,635,000	-828,133,000	-806,443,000	-779,759,000	-764,193,000	-746,603,000	-730,302,000	-714,631,000	-690,945,000	-684,046,000	-667,782,000	-657,186,000	-643,534,000	-626,298,000	-614,000,000	-586,835,000	-546,150,000	-494,644,000	-461,970,000	-427,424,000	-392,568,000	-384,245,000	-395,705,000	-383,588,000	-363,761,000	-341,290,000	-314,022,000	-283,425,000	-261,661,000	-245,633,000	-228,521,000	-213,580,000	-198,967,000	-188,417,000	-179,589,000	-169,569,000	-160,920,000	-152,277,000	-143,574,000	-136,225,000	-130,054,000	-121,694,000	-114,141,000	-103,571,000	-94,203,000	-85,367,000	-78,702,000	-73,265,866	-68,082,467	-62,577,640	-56,616,034
total stockholders’ equity	2,550,421,000	2,619,059,000	2,723,156,000		2,821,811,000	2,932,812,000	2,998,467,000	3,065,139,000	3,164,955,000	1,876,287,000	1,779,601,000	1,271,826,000	1,313,411,000	1,273,943,000	1,364,521,000	1,382,439,000	1,279,337,000	677,569,000	659,708,000	573,532,000	603,377,000	634,087,000	662,290,000	668,524,000	684,106,000	685,911,000	696,238,000	179,618,000	209,289,000	210,834,000	225,186,000	225,830,000	230,994,000	230,185,000	234,380,000	237,115,000	233,266,000	226,148,000	222,576,000	218,517,000	220,181,000	218,849,000	231,244,000	264,028,000	304,829,000	161,518,000	189,787,000	218,556,000	222,128,000	206,200,000	215,547,000	100,090,000	107,491,000	79,018,000	105,808,000	124,121,000	138,062,000	53,986,000	64,669,000	74,459,000	81,580,000	88,234,000	96,743,000	103,813,000	67,973,000	75,458,000	82,748,000	88,511,000	96,848,000	103,833,000	113,514,000	121,884,000	130,796,000	74,878,000	72,145,487	36,150,329	41,085,523	46,701,455	52,001,744	56,459,900	58,414,424
total liabilities and stockholders’ equity	3,634,261,000	3,495,382,000	3,543,296,000		3,619,078,000	3,630,343,000	3,616,693,000	3,719,604,000	3,977,878,000	2,205,866,000	2,097,537,000	1,567,565,000	1,592,604,000	1,503,329,000	1,567,845,000	1,580,917,000	1,473,627,000	877,949,000	853,083,000	757,471,000	784,048,000	838,396,000	849,912,000	863,286,000	879,386,000	895,095,000	907,340,000	407,815,000	446,473,000	458,965,000	478,248,000	469,615,000	476,072,000	483,898,000	477,630,000	466,591,000	466,028,000	471,422,000	415,330,000	420,029,000	412,555,000	425,216,000	420,490,000	453,635,000	480,593,000	329,936,000	348,716,000	358,452,000	367,910,000	388,333,000	326,421,000	212,821,000	220,940,000	187,717,000	214,000,000	225,675,000	237,414,000	148,530,000	141,345,000	148,767,000	154,582,000	97,695,000	107,261,000	115,740,000	80,917,000	90,019,000	98,457,000	106,556,000	111,974,000	119,109,000	126,053,000	134,664,000	142,240,000	81,999,000	78,056,611	41,272,626	46,895,976	52,535,688	57,981,894	61,776,891	61,114,227
liabilities and stockholders' equity
stockholders' equity:
total stockholders' equity				2,803,819,000																																																																														64,670,835	69,180,437
total liabilities and stockholders' equity				3,674,532,000
long-term investments										57,283,000				49,194,000	22,635,000	9,857,000			19,967,000	20,572,000	29,980,000	29,988,000	40,094,000	50,541,000	82,191,000	63,060,000																	12,791,000	13,144,000	13,256,000	13,031,000	12,736,000	11,928,000	12,852,000	26,925,000	39,539,000	49,309,000	60,806,000	65,529,000	82,568,000	84,348,000	48,638,000	18,223,000	32,301,000	38,713,000	31,692,000	3,986,000	9,496,000	6,983,000	34,207,000	36,736,000	45,354,000	50,729,000	55,780,000	68,761,000	71,996,000	76,280,000	81,021,000	32,852,000	36,089,108	18,456,057	16,941,551	17,839,089	18,426,069	17,372,995	6,203,100	23,893,125	23,664,325
in-process research and development										300,000,000	300,000,000	300,000,000	300,000,000	300,000,000	300,000,000	300,000,000	300,000,000
current portion of deferred revenue											7,028,000	17,002,000	26,910,000	33,600,000	36,495,000	35,658,000	35,776,000	34,457,000	32,811,000	31,114,000	29,682,000	27,847,000	30,487,000	34,140,000	39,329,000	46,235,000	51,505,000	47,745,000	47,698,000	48,212,000	47,806,000	42,261,000	40,436,000	39,850,000	43,026,000	40,771,000	43,222,000	44,447,000	32,011,000	32,490,000	33,460,000	38,092,000	35,636,000	35,678,000	34,424,000	29,038,000	24,203,000	23,900,000	48,112,000	85,002,000	27,866,000	27,658,000	27,147,000	24,341,000	23,126,000	21,312,000	20,291,000	18,873,000	14,463,000	14,174,000	14,171,000	3,160,000	4,156,000	5,190,000	5,496,000	6,053,000	6,308,000	6,742,000	5,589,000	4,860,000	3,621,000	4,981,000	4,041,000	2,106,000	982,654	1,191,067	1,217,983	1,301,316
accrued liabilities														147,293,000																																																																	1,821,669	1,376,760	899,940	2,123,884	1,989,446
deferred revenue, less current portion															6,004,000	14,576,000	23,387,000	30,618,000	37,901,000	43,559,000	49,103,000	53,006,000	59,000,000	63,838,000	69,125,000	71,249,000	78,978,000	90,218,000	104,636,000	117,648,000	129,238,000	134,956,000	140,920,000	149,191,000	138,092,000	133,455,000	137,949,000	138,767,000	113,179,000	111,735,000	112,841,000	110,013,000	111,836,000	116,894,000	112,962,000	110,630,000	104,836,000	92,224,000	79,949,000	74,866,000	58,397,000	63,273,000	67,092,000	66,958,000	68,771,000	67,882,000	67,865,000	64,786,000	53,537,000	53,039,000	53,583,000	399,000	648,000	1,201,000	1,884,000	2,950,000	4,113,000	5,272,000	4,284,000	5,129,000	4,785,000	4,072,000	3,308,000	2,899,000	1,462,500	1,618,750	1,832,164	2,074,159
accounts payable and accrued liabilities															157,157,000	145,189,000	132,246,000	132,672,000	119,978,000	106,665,000	99,213,000	120,669,000	95,321,000	93,574,000	83,381,000	88,031,000	76,756,000	86,015,000	80,454,000	77,681,000	71,323,000	61,580,000	58,593,000	59,348,000	56,611,000	49,577,000	45,765,000	56,130,000	42,525,000	52,154,000	40,565,000	53,048,000	38,287,000	33,836,000	25,393,000	25,783,000	26,980,000	20,904,000	14,924,000	19,496,000	21,946,000	19,159,000	17,588,000	15,879,000	14,917,000	11,150,000	9,807,000	10,475,000	8,255,000	6,658,000	4,792,000	5,389,000	5,197,000	5,014,000	5,045,000	5,045,000	4,781,000	5,530,000	4,765,000	4,815,000	3,677,000	3,288,000	3,679,000	1,726,000	3,102,430	1,975,303	2,456,062	2,190,732
current assets
current liabilities
long-term liabilities
deferred rent and other long-term liabilities																	2,881,000	2,633,000	2,685,000	2,601,000	2,673,000	2,787,000	2,814,000	3,210,000	3,445,000	3,669,000	3,863,000	4,219,000	4,396,000	4,590,000	4,695,000	4,988,000	5,129,000	5,324,000	5,521,000	5,673,000	5,826,000	5,930,000	5,039,000	5,133,000	5,508,000	5,214,000	3,487,000	3,199,000	2,985,000	2,967,000	2,910,000	2,868,000	2,797,000	2,769,000	2,665,000	2,641,000	1,622,000	1,521,000	1,378,000	1,210,000	1,389,000
stockholders’ equity
accumulated other comprehensive loss																						-63,000				-683,000				-29,000													-1,617,000	-1,204,000	-1,164,000	-1,373,000	-1,538,000	-2,291,000	-1,005,000	-1,249,000	-473,000	-1,054,000	-1,576,000						51,000	-136,000	-113,000	-37,000	-15,000	-120,000	-196,000	-171,000	-199,000	-147,000	-108,000
accumulated other comprehensive income loss																													-11,000
interest receivable																																		591,000	220,000	613,000	1,161,000	893,000	1,496,000	879,000	837,000	641,000	1,014,000	1,192,000	1,228,000	782,000	1,052,000	1,159,000	2,392,000	1,350,000	1,369,000	1,985,000	2,027,000	1,888,000	2,069,000	1,959,000	1,527,000	758,000	949,000	1,074,000	799,000	539,000	715,000	781,000	688,000	678,000	748,000	898,000	619,000	818,000	785,000	1,190,000	1,036,000	670,000	545,211	177,192	283,716	371,303	494,006	680,349	736,935	940,408	986,096
accumulated other comprehensive gain																																										20,000													-2,103,000	-626,000	300,000	115,000
prepaid expenses and other																																														2,246,000				6,302,000				5,463,000		6,924,000	1,432,000	1,244,000	1,871,000	2,024,000	1,212,000	1,405,000	1,083,000	1,638,000	722,000	314,000	535,000	648,000	580,000	476,000	1,598,000	2,518,000	662,000	345,000
deferred rent																																																										410,000	421,000	437,000	456,000	513,000	517,000	522,000	519,000	513,000	507,000	501,000	488,000	472,000	456,000	439,000	416,000	390,000	363,540	337,177	304,244	268,026	231,808	195,591	152,931	61,173	15,293
series a convertible preferred stock, 1,500,000 shares issued and outstanding at december 31, 2006
series a convertible preferred stock, no shares issued and outstanding at september 30, 2007 and 1,500,000 shares issued and outstanding at december 31, 2006
series a convertible preferred stock, 928,500 shares issued and outstanding at june 30, 2007 and 1,500,000 shares issued and outstanding at december 31, 2006																																																												1,000
series a convertible preferred stock, 928,500 shares issued and outstanding at march 31, 2007 and 1,500,000 shares issued and outstanding at december 31, 2006																																																													1,000
restricted investments																																																														486,000	494,000	488,000	610,000	605,000	600,000	598,000	975,000	977,000	988,000	981,000	980,000	976,000	988,225	986,332	983,325	980,291	1,000,758	994,767	984,016	1,000,687	969,023
series a convertible preferred stock, 1,500,000 shares issued and outstanding at december 31, 2006 and 2005																																																														2,000
series a convertible preferred stock, 1,500,000 shares issued and outstanding at september 30, 2006 and at december 31, 2005																																																															2,000
series a convertible preferred stock, 1,500,000 shares issued and outstanding at june 30, 2006 and at december 31, 2005																																																																2,000
series a convertible preferred stock, 1,500,000 shares issued and outstanding at march 31, 2006 and at december 31, 2005																																																																	2,000
series a convertible preferred stock, 1,500,000 shares issued and outstanding at december 31, 2005 and at december 31, 2004																																																																		2,000
total long-term liabilities:																																																																			4,620,000
series a convertible preferred stock, 1,500,000 shares issued and outstanding																																																																			2,000	2,000	2,000
series a convertible preferred stock, 1,500,000 and 1,640,000 shares issued and outstanding, respectively																																																																						2,000
deferred stock compensation																																																																							-29,000	-124,000	-700,000	-990,000	-809,195	-1,198,597	-1,535,029	-1,965,913
other assets																																																																											35,515	36,406	36,406	36,406	36,406	36,406	36,406	891	28,391
series a convertible preferred stock, 1,640,000 and no shares issued and outstanding, respectively																																																																										2,000
notes receivable from stockholders																																																																												-181,562	-271,533	-271,533
deferred revenue																																																																															1,100,000	766,667	141,667	141,667	141,667
deferred revenue, net of current portion																																																																															2,265,278	2,373,611	165,278	236,111	271,528
prepaid expenses																																																																																		599,266
liabilities, mandatorily redeemable convertible preferred stock and stockholders' equity
mandatorily redeemable convertible preferred stock, 0.001 par value...
series a convertible preferred stock, 7,000,000 shares designated, 6,950,000 shares issued and oustanding
series b convertible preferred stock, 10,437,072 shares issued and outstanding
stockholders' equity
deficit accumulated during the development stage
total liabilities, mandatorily redeemable convertible preferred stock and stockholders' equity																																																																																		68,013,961	73,445,717
the accompanying notes are an integral part of these financial statements
prepaid expenses and reimbursable costs																																																																																			2,371,166
series a convertible preferred stock, 7,000,000 designated, 6,950,000 shares issued and outstanding

Cashflow Statements:

Quarterly

Annual

Unit: USD	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-12-31	2014-09-30	2014-06-30	2014-03-31	2013-12-31	2013-09-30	2013-06-30	2013-03-31	2012-12-31	2012-09-30	2012-06-30	2012-03-31	2011-12-31	2011-09-30	2011-06-30	2011-03-31	2010-12-31	2010-09-30	2010-06-30	2010-03-31	2009-12-31	2009-09-30	2009-06-30	2009-03-31	2008-12-31	2008-09-30	2008-06-30	2008-03-31	2007-12-31	2007-09-30	2007-06-30	2007-03-31	2006-12-31	2006-09-30	2006-06-30	2006-03-31	2005-12-31	2005-09-30	2005-06-30	2005-03-31	2004-12-31	2004-09-30	2004-06-30	2004-03-31	2003-12-31	2003-09-30	2003-06-30	2003-03-31	2002-12-31	2002-09-30	2002-06-30	2002-03-31

operating activities:
net income	-215,789,000	-211,528,000	-174,737,000	-148,171,000	-190,816,000	-134,827,000	-136,494,000	-174,628,000	25,830,000	-91,913,000	-79,238,000	-13,329,000	-119,805,000	-67,446,000	76,273,000	-111,715,000	-59,201,000	50,021,000	-56,360,000	-59,990,000	-55,138,000	-31,752,000	-32,743,000	-20,478,000	-24,856,000	-26,438,000	-47,502,000	-21,690,000	-26,684,000	-15,566,000	-17,590,000	-16,301,000	-15,671,000	-23,686,000	-6,899,000	-16,264,000	-10,596,000	-13,652,000	-17,236,000	-12,298,000	-27,165,000	-40,685,000	-51,506,000	-32,674,000	-34,546,000	-34,856,000	-8,323,000	11,460,000	-12,117,000	-19,827,000	-22,471,000	-27,268,000	-30,597,000	-21,764,000	-16,028,000	-17,112,000	-14,941,000	-14,613,000	-10,550,000	-8,828,000	-10,020,000	-8,649,000	-8,643,000	-8,703,000	-7,349,000	-6,171,000	-8,360,000	-7,553,000	-10,570,000	-9,368,000	-8,836,000	-6,665,000	-5,436,168	-5,183,399	-5,504,827	-5,961,606	-5,814,381	-5,088,136	-6,266,085	-5,991,936
adjustments to reconcile net income to net cash used by operating activities
share-based compensation	131,343,000	93,216,000	63,939,000	64,317,000	58,938,000	54,129,000	43,913,000	52,109,000	47,602,000	27,875,000	26,157,000	25,715,000	25,693,000	20,813,000	15,517,000	16,838,000	15,903,000	15,906,000	17,528,000	14,465,000	15,426,000	12,760,000	12,103,000	12,182,000	13,116,000	11,148,000	9,837,000	7,735,000	11,601,000	10,279,000	9,435,000	9,304,000
depreciation	13,189,000	12,444,000	12,423,000		11,775,000	11,465,000	11,402,000
amortization of intangible assets	5,817,000	5,754,000	5,690,000	5,816,000	5,817,000	5,753,000	5,691,000	5,816,000
amortization of right-of-use assets	3,985,000	3,375,000	3,979,000		3,301,000	3,188,000	2,952,000			2,424,000	2,412,000	2,421,000
amortization of premiums, accretion of discounts, and (gains) losses on debt securities	-11,291,000	-11,768,000	-11,274,000	-5,936,000	-1,613,000	300,000	184,000	1,241,000						-873,000
losses on equity securities	-491,000	3,004,000	237,000
deferred income taxes	286,000	338,000	211,000	774,000	336,000	-712,000	155,000
inventory write-off	0
changes in operating assets and liabilities
accounts receivable	-45,507,000	-90,271,000	6,135,000	-15,157,000	-48,714,000	-37,032,000	-11,753,000	-2,087,000	-45,683,000	-8,054,000	-25,309,000	-10,674,000	6,239,000	-2,544,000	-31,397,000	-17,531,000	5,658,000	-18,492,000	1,747,000	-11,759,000	3,193,000	-7,379,000	-5,350,000	538,000	10,568,000	-18,248,000	4,337,000	-10,339,000	4,569,000	-8,912,000	2,991,000	-8,388,000	-300,000	18,461,000	-2,948,000	-11,278,000	1,713,000	-3,603,000	25,028,000	-1,626,000	-39,508,000	-4,436,000	-2,390,000	10,658,000	-4,017,000	-82,000	-1,365,000	66,307,000	-76,128,000	2,023,000	5,863,000	-3,694,000	-1,591,000	997,000	-227,000	-1,377,000	-600,000	-403,000	-1,252,000	-2,835,000	-164,000	25,000	-402,000	326,000	189,000	-230,000	266,000	569,000	-830,000	58,000	466,000	-345,000	205,835	88,030	-811,376	63,511				30,027
inventories	-44,334,000	-55,684,000	-50,483,000	-62,241,000	-45,616,000	-43,607,000	-75,084,000	-19,288,000	6,102,000	-18,884,000	-5,914,000	-13,997,000	21,933,000	-4,239,000	982,000	-11,937,000	859,000	8,410,000	-8,524,000	7,401,000	3,521,000	30,000	-11,625,000	-3,087,000	-12,448,000	2,974,000	-4,420,000	382,000	-5,910,000	-7,050,000	-1,447,000	-1,971,000	-1,069,000	12,657,000	-4,929,000	4,015,000	-3,451,000	-8,599,000	-9,944,000	-6,284,000	-6,041,000
prepaid expenses and other assets	-42,477,000	-11,250,000	541,000	-5,006,000	25,949,000	-12,726,000	-24,523,000	-8,519,000	-955,000	-2,861,000	-1,127,000	7,402,000	-18,750,000	9,175,000	6,537,000	-11,529,000	-86,000	3,435,000	-5,964,000	445,000	-159,000	-3,412,000	1,865,000	-2,672,000	-4,897,000	3,506,000	-4,213,000	3,652,000	-4,031,000	-94,000	-453,000	-654,000
lease liability	-3,306,000	-2,982,000	-3,969,000		-3,309,000	-3,375,000	-5,158,000		-2,027,000	-1,678,000	-471,000	-2,484,000
other liabilities	172,752,000	43,583,000	-102,335,000	74,426,000	95,554,000	81,375,000	-30,876,000	-155,849,000	15,642,000	32,488,000	11,731,000	-12,410,000
net cash used by operating activities	-35,823,000	-175,245,000	-249,643,000		-85,729,000	-71,770,000	-216,812,000		-11,851,000	-60,646,000	-34,013,000	-57,227,000	-24,285,000	-11,116,000	-20,971,000	-147,164,000
capital expenditures	-43,930,000	-49,230,000	-38,655,000		-15,934,000	-14,764,000	-17,397,000		-18,990,000	-18,432,000	-20,797,000	-12,534,000	-6,278,000	-5,451,000	-4,817,000	-4,673,000
free cash flows	-79,753,000	-224,475,000	-288,298,000		-101,663,000	-86,534,000	-234,209,000		-30,841,000	-79,078,000	-54,810,000	-69,761,000	-30,563,000	-16,567,000	-25,788,000	-151,837,000
investing activities:
purchases of securities	-573,852,000	-507,313,000	-618,151,000	-402,022,000	-570,915,000	-833,387,000	-655,940,000	-1,035,443,000	-326,856,000	-518,565,000	-69,074,000	-78,481,000	-137,978,000	-131,677,000	-180,051,000	-62,628,000
proceeds from maturities of securities	760,500,000	690,000,000	891,500,000	397,000,000	656,000,000	1,035,000,000	700,000,000	1,050,000,000	411,000,000	155,000,000	92,500,000	127,500,000	128,001,000	60,699,000	90,000,000	120,022,000
payments for lessor-owned assets	-227,000	-369,000	-2,358,000	-2,223,000	-4,180,000
purchases of property and equipment	-43,930,000	-49,230,000	-38,655,000	-29,245,000	-15,934,000	-14,764,000	-17,397,000	-13,575,000	-18,990,000	-18,432,000	-20,797,000	-12,534,000	-6,278,000	-5,451,000	-4,817,000	-4,673,000	13,893,000	-5,059,000	-22,973,000	-14,583,000	-8,950,000	-8,201,000	-3,351,000	-7,333,000	-4,366,000	-4,069,000	-2,586,000	-2,371,000	-7,395,000	-2,641,000	-3,999,000	-3,141,000	-7,361,000	-6,402,000	-2,137,000	-6,254,000	-5,806,000	-2,353,000	-1,271,000	-1,055,000	-6,236,000	-3,431,000	-1,282,000	-303,000	-415,000	-876,000	-1,204,000	-1,053,000	-706,000	-677,000	-1,320,000	-1,886,000	-910,000	-1,303,000	-1,557,000	-1,114,000	-1,957,000	-908,000	-532,000	-886,000	-522,000	-452,000	-532,000	-174,000	-212,000	-597,000	-182,000	-411,000	-362,000	-1,636,000	-2,947,000	-778,000	-235,883	-109,114	-107,787	-136,216
net cash from investing activities	142,491,000	133,088,000	232,336,000		64,971,000												19,879,000	-71,341,000	161,520,000	19,803,000	-19,089,000	-42,381,000	100,232,000	29,431,000	-494,965,000	43,704,000	55,028,000	20,383,000	26,282,000	18,230,000	-4,042,000	-3,848,000	-63,411,000	49,402,000	-3,984,000	-6,643,000	-57,779,000	7,516,000	-15,893,000	-14,020,000	5,452,000	71,396,000	47,298,000	-121,592,000	18,439,000	-17,799,000	33,559,000	-45,769,000	-37,541,000	-71,532,000	-3,615,000	-34,730,000	31,954,000	-2,887,000	-64,898,000	-31,997,000	39,062,000	15,657,000	-4,745,000	-45,901,000	-9,127,000	301,000	-10,829,000	8,894,000	7,357,000	3,768,000			317,000	2,790,000	8,545,000	-51,982,000	-3,492,415	-38,357,076	4,349,194	6,664,297	4,976,756
financing activities:
proceeds from exercise of stock options and employee stock purchase plan	15,522,000	13,815,000	42,240,000	65,347,000	18,389,000	14,960,000	26,664,000	22,347,000	27,793,000	23,306,000	11,226,000	26,826,000	3,269,000	28,846,000	11,145,000	11,905,000	15,320,000	10,608,000	4,548,000	10,835,000	11,787,000	12,911,000	4,800,000	5,698,000	2,102,000	5,298,000	7,971,000	12,392,000	1,260,000	4,898,000	2,244,000	7,786,000		12,673,000	3,995,000	16,786,000		11,389,000	10,038,000	7,584,000		2,824,000	6,548,000	3,390,000		1,598,000				3,443,000	424,000	693,000		2,502,000	267,000	1,147,000		2,634,000	1,411,000	876,000	43,000	183,000
employee taxes paid related to net share settlement of stock-based awards	0	0	-12,303,000
net cash from financing activities	15,522,000	13,815,000	29,937,000	65,347,000	18,389,000	14,960,000	26,664,000	22,347,000	27,793,000	571,997,000	11,226,000	26,826,000	3,269,000	28,846,000	11,222,000	670,070,000	15,320,000	10,608,000	4,548,000	10,835,000	11,787,000	12,911,000	4,800,000	5,698,000	2,102,000	531,916,000	7,971,000	12,392,000	1,260,000	4,898,000	2,244,000	7,786,000	1,745,000	12,673,000	3,995,000	16,786,000	6,713,000	11,389,000	10,038,000	7,584,000	7,169,000	2,824,000	6,483,000	171,508,000	1,880,000	1,598,000	2,859,000	1,040,000	186,000	131,657,000	11,819,000	53,225,000	70,000	2,502,000	267,000	98,775,000	1,683,000	2,634,000	1,411,000	876,000	43,000	183,000	43,408,000	289,000	29,000	460,000	62,000	601,000	857,000	299,000	97,000	62,376,000	7,772,711	41,384,766	-228,987	74,510	1,498	69,596	3,504,984	3,071,931
effect of exchange rate changes on cash, cash equivalents, and restricted cash	-2,290,000	566,000	920,000	5,699,000	-4,084,000
net increase in cash, cash equivalents, and restricted cash			13,550,000	-44,884,000
cash, cash equivalents, and restricted cash at beginning of period	0	0	323,486,000		0
cash, cash equivalents, and restricted cash at end of period	119,900,000	-27,776,000	337,036,000		-6,453,000
net decrease in cash, cash equivalents, and restricted cash
adjustments to reconcile net income to net cash (used) provided by operating activities
depreciation and amortization									9,628,000	4,241,000	4,961,000	4,944,000	6,987,000	5,212,000	6,823,000	7,010,000	7,876,000	6,178,000	5,431,000	4,784,000	4,764,000	4,624,000	4,416,000	4,230,000	3,745,000	3,725,000	3,612,000	3,423,000	3,382,000	3,209,000	3,062,000	2,837,000	2,558,000	2,216,000	2,114,000	1,727,000	1,597,000	1,539,000	1,529,000	1,494,000	1,391,000	1,008,000	896,000	875,000	938,000	934,000	874,000	816,000	846,000	856,000	820,000	738,000	927,000	879,000	835,000	774,000	669,000	651,000	635,000	593,000	616,000	606,000	608,000	588,000	600,000	590,000	577,000	566,000	569,000	481,000	355,000	339,000	332,354	333,164	330,372	330,110	334,917	318,149	297,626	280,781
amortization of right-of-use-assets
gain on equity securities
gain on disposals of property and equipment
changes in operating assets and liabilities:
lease liabilities
net cash (used) provided by operating activities								-283,383,000
proceeds from sales of securities													0	14,869,000	77,014,000	48,469,000
net cash provided (used) by investing activities							26,663,000	982,000			2,629,000	36,485,000	-16,255,000	-61,560,000	-17,854,000	-496,961,000
net proceeds from issuance of common stock									0				0	0	77,000	658,165,000									0																0	0	-65,000	168,118,000					0	128,214,000	11,395,000	52,532,000	0	0	0	97,628,000					0	0	42,857,000	289,000	29,000	460,000	62,000	601,000	857,000	299,000	97,000	62,376,000	7,772,244	504,640	4,606	74,510	1,498	69,596	3,504,984	3,071,931
cash, cash equivalents, and restricted cash at beginning of year
cash, cash equivalents, and restricted cash at end of year
losses (gains) on equity securities					2,669,000	4,299,000	2,779,000
effect of exchange rate changes on cash and cash equivalents							-353,000	-285,000
net decrease in cash and cash equivalents							-163,838,000																								-5,981,000	-19,304,000			-7,302,000	-19,729,000												-154,000
cash and cash equivalents at beginning of period							424,834,000			0	0	78,186,000		0	0	160,945,000		0	0	108,673,000		0	0	102,255,000		0	0	56,927,000		0	0	64,116,000		0	0	54,663,000		0
cash and cash equivalents at end of period							260,996,000			129,354,000	-20,158,000	84,270,000		-43,830,000	-27,603,000	186,890,000		-68,964,000	121,337,000	75,767,000		-61,059,000	72,541,000	119,547,000		535,061,000	16,442,000	62,571,000		11,337,000	-5,981,000	44,812,000		91,897,000	-7,302,000	34,934,000		-5,829,000
adjustments to reconcile net income to net cash provided (used) by operating activities
(gain) loss on disposals of property and equipment
deferred revenue									-7,028,000	-9,974,000	-9,908,000	-6,690,000	-8,899,000	-7,735,000	-8,929,000	-8,350,000	-6,737,000	-3,961,000	-4,112,000	-2,068,000	-8,634,000	-8,491,000	-10,476,000	-9,030,000	-12,999,000	-7,480,000	-14,371,000	-13,526,000	-11,184,000	-173,000	-4,139,000	-7,685,000	7,923,000	6,892,000	-6,945,000	-2,043,000	38,024,000	965,000	-2,076,000	-1,804,000	633,000	-5,100,000	5,186,000	7,718,000	10,629,000	12,915,000	-11,937,000	-31,807,000	73,605,000	-4,668,000	-3,308,000	2,940,000	-598,000	2,703,000	1,038,000	4,497,000	15,659,000	787,000	-541,000	64,195,000	-1,245,000	-1,587,000	-989,000	-1,623,000	-1,418,000	-1,593,000	2,141,000	-116,000	1,583,000	-647,000	1,704,000	2,344,000	2,560,321	-364,663	-240,330	-325,328	10,197	225,000
net increase in cash and cash equivalents								-260,339,000	81,096,000			6,084,000	-37,271,000	-43,830,000	-27,603,000	25,945,000	32,805,000	-68,964,000	121,337,000	-32,906,000	-22,356,000	-61,059,000	72,541,000	17,292,000	-511,819,000	535,061,000	16,442,000	5,644,000	6,759,000				-55,413,000				-268,000	-5,829,000	7,417,000	-34,291,000	-24,471,000	32,308,000	18,328,000	40,342,000	-1,644,000	-26,722,000			-53,574,000			-59,000	6,387,000			55,479,000	46,245,000	8,324,000	-12,433,000	8,371,000	-18,774,000	-7,254,000	23,456,000	553,000	250,000	-3,324,000	3,827,000	758,000	-5,315,000	-3,542,000	1,616,000	7,261,000	1,593,011			1,272,017	285,003
cash and cash equivalents at beginning of year																																								87,634,000
cash and cash equivalents at end of year																																								53,343,000
gains on equity securities														23,765,000
loss on disposals of property and equipment
income tax benefit on unrealized loss on available-for-sale securities
acquisition of manufacturing facility
acquisition of cascadian therapeutics, inc., net of cash acquired													0	0	0	-598,151,000
(gains) losses on equity securities										5,690,000	42,693,000	-38,125,000
net cash used by investing activities
amortization of premiums, accretion of discounts and (gains) losses on debt securities
other long-term liabilities													646,000	613,000
accounts payable and accrued liabilities													30,924,000	12,143,000	18,886,000	-28,877,000	12,890,000	17,286,000	7,466,000	-18,544,000	21,572,000	1,856,000	8,150,000	-1,639,000	7,172,000	-9,763,000	6,012,000	3,118,000	8,394,000	6,668,000	3,907,000	-521,000	4,176,000	3,870,000	3,812,000	-10,365,000	13,605,000	-9,629,000	11,589,000	-12,483,000	14,761,000	4,451,000	8,443,000	-390,000	-1,197,000	6,076,000	5,980,000	-4,572,000	-2,450,000	2,787,000	1,571,000	1,709,000	962,000	3,871,000	1,758,000	-420,000	1,453,000	1,597,000	1,855,000	-650,000	192,000	183,000			264,000	-749,000	765,000	-50,000	1,138,000	778,000	1,000	1,172,000	-1,376,698	1,127,127	-480,759	265,330
gain on immunomedics warrant derivative
operating activities
amortization of premiums, accretion of discounts and loss on investments																-146,000				1,836,000
deferred rent and other long-term liabilities																248,000	-52,000	84,000	-72,000	-114,000	-27,000	-396,000	-235,000	-224,000	-194,000	-356,000	-177,000	-194,000	-105,000	-293,000	-141,000	-195,000	-197,000	-152,000	-153,000	-104,000	891,000	-94,000	-375,000	294,000	1,727,000	288,000	214,000	18,000	57,000	42,000	71,000	28,000	104,000	24,000	1,019,000	101,000	143,000	150,000	-179,000	997,000
unrealized losses on equity securities																18,825,000
investing activities
financing activities
adjustments to reconcile net income to net cash from operating activities
amortization of premiums, accretion of discounts and (gain) loss on investments
net gain on immunomedics warrant derivative
income tax benefit on unrealized gain on available-for-sale securities																	-27,942,000
net cash from operating activities																	-2,394,000	-8,231,000	-44,731,000	-63,544,000	-15,054,000	-31,589,000	-32,491,000	-17,837,000	-18,956,000	-40,559,000	-46,557,000	-27,131,000	-20,783,000	-11,791,000	-4,183,000	-23,242,000	6,253,000	29,822,000	-7,313,000	-29,872,000	50,798,000	-24,734,000	13,272,000	-27,855,000	-37,092,000	-41,912,000	-35,453,000	-9,574,000	-21,963,000	-10,521,000	-5,257,000	44,575,000	-16,219,000	-14,656,000	-12,354,000	-18,554,000	-25,637,000	-10,110,000	-15,584,000	-11,299,000	5,500,000	-9,967,000	-9,099,000	53,396,000	-9,690,000	-7,738,000	-9,123,000	-8,630,000	-7,136,000	-7,552,000	-4,608,000	-6,176,000	-6,489,000	-6,631,000	-7,026,000	-3,133,000	-2,687,285	-3,623,981	-5,944,944	-5,466,790
purchases of available-for-sale securities
proceeds from maturities of available-for-sale securities
proceeds from sales of available-for-sale securities
purchase of cost-method investment																									0	0
purchases of securities available-for-sale																		-191,782,000	-45,507,000	-208,370,000
proceeds from maturities of securities available-for-sale																		125,500,000	230,000,000	182,700,000
proceeds from sales of securities available-for-sale																		0	0	60,056,000																		5,000,000	0	5,825,000
amortization of premiums, accretion of discounts and gain on investments																																	353,000	297,000	459,000	774,000	804,000	754,000
purchases of securities available for sale																					-160,439,000	-114,180,000	-216,417,000	-112,736,000	-577,599,000	-55,527,000	-58,191,000	-63,346,000	-120,195,000	-97,629,000	-105,243,000	-128,207,000	-142,739,000	-130,312,000	-139,042,000	-71,089,000	-158,672,000	-91,131,000	-131,622,000	-123,641,000	-95,316,000	-60,454,000	-84,720,000	-238,899,000	-124,676,000	-118,879,000	-63,937,000	-146,107,000	-167,475,000	-122,649,000	-55,834,000	-50,882,000	-1,000	-21,097,000	-75,275,000	-57,964,000	-23,497,000	-22,060,000	-57,044,000	-83,316,000
proceeds from maturities of securities available for sale																					150,300,000	80,000,000	320,000,000	149,500,000	87,000,000	103,300,000	90,800,000	86,100,000	152,900,000	118,500,000	105,200,000	127,500,000	86,500,000	186,200,000	137,300,000	70,700,000	107,300,000	96,000,000	117,000,000	104,851,000	107,006,000	141,043,000	133,300,000	117,610,000	143,275,000	99,890,000	98,700,000	101,391,000	130,640,000	51,725,000	52,520,000	17,034,000	32,865,000	12,513,000	11,934,000	27,081,000	62,516,000	36,375,000	52,831,000	38,301,000
proceeds from sales of securities available for sale																									0	0																			255,000				0	69,000	1,019,000	1,004,000	0				2,000,000
amortization of premiums and accretion of discounts																						571,000	1,404,000	2,343,000		373,000	328,000	308,000		141,000	192,000	332,000
interest receivable																																	-371,000	393,000	548,000	-268,000	603,000	-617,000	-42,000	-196,000	373,000	178,000	36,000	-446,000	270,000	107,000	1,233,000	-1,042,000	19,000	616,000	42,000	-139,000	181,000	-110,000	-432,000	-769,000	191,000	125,000	-275,000	-260,000	176,000	66,000	-93,000	-10,000	70,000	150,000	-279,000	199,000	-33,000	405,000	-154,000	-366,000	-125,092	-368,019	106,524	87,587	122,703	186,343
investments in other non-current assets
proceeds from exercise of stock options, warrants and employee stock purchase plan
share-based compensation expense																																		8,231,000	6,780,000	6,606,000	7,431,000	6,272,000	5,536,000	6,101,000	5,964,000	5,490,000	4,262,000	4,268,000	4,232,000	3,736,000	3,178,000	3,184,000	3,360,000	3,046,000	2,729,000	2,714,000	3,012,000	2,426,000	2,746,000	2,228,000	2,511,000	2,002,000	2,041,000	1,374,000
prepaid expenses and other current assets																																		643,000	848,000	-2,672,000	177,000	1,930,000	-1,306,000	-1,500,000	1,505,000	-962,000	-1,690,000	-427,000		6,000	4,081,000	-1,226,000		-284,000	238,000	3,463,000																						38,752	39,860	-404,755
purchases of other non-current assets																																		-84,000
amortization of discounts, accretion of premiums and gain on investments																																								447,000
amortization of discounts, accretion of premiums and loss on investments
change in other non-current assets																																									-2,000
amortization and accretion on investments																																										1,081,000	1,298,000	827,000	481,000
proceeds from sale of securities available for sale
cash and cash equivalents, at beginning of period																																										0	0	21,127,000	0	0	0	18,486,000	0	0	0	30,800,000	0	0	0	59,644,000	0	0	0	9,137,000	0	0	0	11,156,000	0	0	0	9,645,000	0	0	0	9,625,000	84	0	0	9,180,916	0	0	0	8,293,504
cash and cash equivalents, at end of period																																										32,308,000	18,328,000	61,469,000	-1,644,000	-26,722,000	31,161,000	18,332,000	-53,574,000	45,469,000	-4,150,000	30,741,000	6,387,000	-10,495,000	-80,215,000	115,123,000	46,245,000	8,324,000	-12,433,000	17,508,000	-18,774,000	-7,254,000	23,456,000	11,709,000	250,000	-3,324,000	3,827,000	10,403,000	-5,315,000	-3,542,000	1,616,000	16,886,000	1,593,095	-596,291	-1,824,737	10,452,933	285,003	4,770,915	-2,224,336	6,349,334
other non-current assets																																											-202,000	-1,000	-5,000	1,000	1,000	29,000	27,000
prepaid expenses and other																																																							-5,491,000	-188,000	627,000	-22,000	-812,000	193,000	-346,000	555,000	-916,000	-384,000	216,000	116,000	-66,000	-104,000	1,121,000	920,000	-1,855,000	-317,000
proceeds from exercise of options and warrants to purchase common stock
amortization on investments																																																		826,000	1,143,000	882,000		568,000	396,000	71,000		-75,000	-192,000	-382,000				216,000	285,000	329,000	337,000	284,000	421,000	622,000	737,000	536,000	446,858	341,524			131,796	176,049
amortization of investments																																																1,398,000																												97,752
proceeds from exercise of options to purchase common stock																																																1,040,000
realized losses and amortization on investments
deferred rent																																																									-11,000	-16,000	-8,000	-4,000		-5,000	3,000	6,000	6,000	6,000	13,000	16,000	16,000	17,000	23,000	26,000	26,486	26,363	32,933	36,218	36,218	36,217	42,659	45,880
supplemental disclosures
non-cash investing and financing activities
property and equipment purchase costs accrued
stock-based compensation expense																																																																	2,000	0			80,000	103,000	533,000	153,000	341,163	338,653			524,788	588,806
stock compensation expense																																																														1,291,000	999,000	954,000				10,000
realized loss and amortization on investments																																																														-223,000
purchases of investments																																																														-15,695,000	-56,991,000	-6,823,000	-3,496,000	-8,034,000	-14,720,000	-11,775,000	-22,727,000	-29,321,000	-12,105,000	-61,664,000	-14,469,529	-46,598,834	-3,554,322	-1,874,315
proceeds from sales and maturities of investments																																																														16,448,000	46,694,000	15,891,000				18,519,000
proceeds from sale and maturities of investments																																																																	11,065,000	12,399,000			23,406,000	33,747,000	23,597,000	10,460,000	11,212,997	8,350,872	8,011,303	8,674,828	7,264,208	12,039,551	7,199,004	5,916,950
net proceeds from issuance of preferred stock and warrants
collection of notes receivable from stockholders
adjustments to reconcile net income to net cash from operating activities:
realized gain on sale of investments																																																																		0			0	0	0	-10,000	-487
non-cash investing and financing activities:
decrease in deferred stock compensation																																																																							-437,000	-137,000
property and equipment purchase cost accrued
loss on disposal of property and equipment																																																																				2,000
realized (gain) loss on investments																																																																				1,000
net cash from (provided by) investing activities																																																																				6,333,000
increase in deferred stock compensation																																																																					0							-86,493	-26,575	-230,192	-15,089	370,152
net proceeds from issuance of series a convertible preferred stock and common stock warrants
collection of notes receivable
prepaid private placement costs
leasehold improvement construction costs accrued																																																																							-392,000	781,000
gain on disposal of property and equipment																																																																													0
proceeds from disposal of property and equipment
collection of note receivable from stockholder
supplemental disclosure of cash flow information
non-cash investing and financing activities increase in deferred stock compensation
stock-based compensation																																																																												344,391
realized (gain) loss on sale of investments
proceeds from subscription receivable
net proceeds from issuance of series b preferred stock
prepaid public offering costs
book overdraft
issuance of common stock in exchange for notes receivable
accounts payable																																																																														-42,967	-735,624	1,031,493
accrued liabilities																																																																														444,909
conversion of preferred stock to common stock
amortization of deferred compensation																																																																																879,527
realized loss on sale of investments
amortization (accretion) on investments																																																																																195,629
cash flows from operating activities
realized loss on sale of securities
amortization/ accretion on investments
common stock bonus provided to employees
prepaid expenses, reimbursable costs and other assets
cash flows from investing activities
purchase of property and equipment
cash flows from financing activities
net proceeds from issuance of series a preferred stock
supplemental disclosure of cash information
issuance of series b preferred stock for subscription notes receivable

Seagen Inc(NASDAQ:SGEN)

Seagen Inc
(NASDAQ:SGEN)