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Recursion Pharmaceuticals, Inc.
(NASDAQ:RXRX) 

RXRX stock logo

Recursion Pharmaceuticals, Inc. operates as a clinical-stage biotechnology company decoding biology by integrating technological innovations across biology, chemistry, automation, data science, and engineering to industrialize drug discovery. It has four clinical-stage drug candidates focused on rar...

Founded: 2013
CEO: Chris Gibson  
Sector: Healthcare
Industry: Biotechnology

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At a glance:
  • AI-Driven Drug Discovery Platform with High R&D Intensity: Recursion Pharmaceuticals applies machine learning to large-scale biological and chemical datasets to accelerate drug discovery, which results in substantial ongoing R&D spend relative to current revenues.
  • Revenue Base is Limited; Progress Tied to Partnerships and Milestones: The company’s near-term revenue is typically driven by collaboration agreements, upfront payments, and milestone potential rather than broad commercial product sales.
  • Pipeline Execution and Clinical Readouts Are Key Value Drivers: Share performance and fundamentals are highly sensitive to clinical trial progress, efficacy/safety data, and decisions to advance or discontinue internal programs.
  • Cash Burn is a Core Focus; Runway Depends on Capital Strategy: As a pre-commercial/early-commercial biotech, Recursion commonly operates at a loss with meaningful cash usage, making liquidity, financing conditions, and potential non-dilutive funding important considerations.
  • Model Performance and Data Moat Are Competitive Differentiators: Sustained advantage depends on the quality/scale of proprietary datasets, predictive model performance, and the ability to translate computational insights into validated therapeutics.
Bull Thesis:
  • Proprietary AI-Driven Drug Discovery Platform: Recursion's integrated 'Recursion OS' platform, combining high-throughput wet-lab experimentation with advanced AI/ML, offers a potentially transformative approach to drug discovery, aiming to accelerate identification of novel targets and compounds with higher success rates than traditional methods.
  • Exponential Data Generation and Platform Learning: The company's automated wet labs generate an unprecedented scale of biological and chemical data, which continuously feeds and improves their machine learning models. This creates a powerful data moat and network effect that enhances drug discovery capabilities and predictive power over time.
  • Validation Through Strategic Partnerships: Collaborations with industry giants like Bayer, Roche/Genentech, and NVIDIA not only provide significant non-dilutive funding and external validation of Recursion's technology but also offer access to vast resources, expertise, and computing power, accelerating pipeline development and market reach.
  • NVIDIA Investment and AI Integration: NVIDIA's significant investment and strategic partnership underscore the potential of Recursion's AI-first approach. This collaboration provides access to cutting-edge computing infrastructure and AI expertise crucial for scaling their machine learning models and accelerating drug discovery at an unprecedented pace.
Bear Thesis:
  • Unproven AI-Driven Drug Discovery Efficacy: While promising, the long-term efficacy and superiority of Recursion's AI-driven platform in consistently delivering successful drug candidates to market at scale remain largely unproven. The technology still faces the same high failure rates and lengthy timelines inherent in traditional drug development, despite the AI acceleration.
  • High Cash Burn and Future Funding Needs: Recursion operates with a substantial cash burn rate due to extensive R&D, platform development, and clinical trials. This necessitates significant future capital raises that could lead to substantial shareholder dilution or increased debt, especially if clinical milestones are delayed or missed.
  • Intense Competition in AI Drug Discovery: The AI drug discovery space is becoming increasingly crowded with well-funded startups and established pharmaceutical companies developing their own AI capabilities. This intense competition could erode Recursion's competitive edge, make it harder to attract top talent, or secure future partnerships on favorable terms.
  • Inherent Clinical Trial and Regulatory Risks: Despite an AI-accelerated discovery process, Recursion's drug candidates are still subject to the same high failure rates, lengthy timelines, and stringent regulatory hurdles of traditional clinical trials. Any setbacks in these phases can significantly impact timelines, commercial viability, and investor confidence.
Main Competitors:
  • BenevolentAI ($BAI.L) (AI-driven drug discovery platform and pipeline), Competes directly by leveraging its own AI-driven drug discovery platform and extensive biomedical knowledge graph to identify novel drug targets and accelerate the development of new therapeutics, aiming for similar efficiencies and success rates as Recursion.
  • Exscientia ($EXAI) (AI-driven precision medicine platform), Competes by employing its AI-driven precision medicine platform to design novel molecules and optimize drug candidates, aiming to bring drugs to clinical trials faster and with higher success rates, directly challenging Recursion's AI-first approach to drug discovery.
  • Insilico Medicine (End-to-end AI-driven drug discovery and development platform (Pharma.AI)), Competes by utilizing its end-to-end AI-driven drug discovery platform to discover novel targets and generate new molecules, demonstrating rapid pipeline progression and aiming to industrialize drug discovery through AI, similar to Recursion's vision.
  • Schrödinger ($SDGR) (Physics-based computational platform for drug discovery and materials science), Competes by offering a leading physics-based computational platform that significantly accelerates drug discovery and optimization. While different in its core computational approach (physics-based vs. Recursion's image-based/phenotypic AI), it provides powerful tools that reduce the need for extensive wet-lab experimentation, and they also have their own drug discovery pipeline, thus vying for similar efficiencies and breakthroughs in drug development.
  • Novartis ($NVS) (Internal R&D pipelines, various therapeutic drugs), Competes as a large, established pharmaceutical company that is aggressively investing in and integrating AI and machine learning into its internal R&D processes. While not an 'AI-first' startup, Novartis's internal AI initiatives and partnerships aim to achieve similar efficiencies in drug discovery and development, potentially identifying novel targets and compounds faster, thus competing for market share, talent, and scientific breakthroughs in the broader drug development landscape.
Moat:
Recursion Pharmaceuticals' core competitive advantage lies in its proprietary 'Recursion OS,' which integrates high-throughput experimental biology with an AI-driven platform to generate and analyze a massive, high-dimensional biological dataset for industrial-scale drug discovery. Competition is fierce and comes from several angles: direct AI-first drug discovery companies (like BenevolentAI, Exscientia, Insilico Medicine) that are building similar proprietary platforms and pipelines; computational chemistry/biology platforms (like Schrödinger) that offer powerful tools to accelerate drug design; and large, established pharmaceutical companies (like Novartis) that possess vast resources and are aggressively investing in and integrating AI/ML into their internal R&D. Recursion's success hinges on its ability to consistently translate its AI-driven insights into successful clinical candidates, demonstrate superior speed and cost-effectiveness, and protect its proprietary data and algorithms in a rapidly evolving landscape where data, computational power, and biological insights are key battlegrounds.
Income Statements:
Quarterly
Annual
    Unit: USD2026-03-31 2025-09-30 2025-06-30 2025-03-31 2024-09-30 2024-06-30 2024-03-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-09-30 2021-06-30 2021-03-31 
                     
      revenue
                     
      yoy
                     
      qoq
                     
      operating revenue
    6,301,000 4,983,000 19,103,000 14,818,000 26,082,000 14,404,000 13,491,000 10,102,000 11,016,000 12,134,000 13,676,000 13,053,000 7,653,000 5,299,000 2,500,000 2,500,000 2,500,000 
      grant revenue
    171,000 192,000 120,000 -73,000  13,000 303,000 431,000 1,000   107,000 21,000 34,000 34,000 49,000 62,000 
      total revenue
    6,472,000 5,175,000 19,223,000 14,745,000 26,082,000 14,417,000 13,794,000 10,533,000 11,017,000 12,134,000 13,676,000 13,160,000 7,674,000 5,333,000 2,534,000 2,549,000 2,562,000 
      operating costs and expenses
                     
      cost of revenue
    12,490,000 14,687,000 20,161,000 21,829,000 12,079,000 9,199,000 11,166,000 10,877,000 9,382,000 12,448,000 10,840,000 15,409,000 14,227,000 7,799,000    
      research and development
    87,896,000 121,062,000 128,636,000 129,634,000 74,600,000 73,928,000 67,560,000 70,007,000 55,060,000 46,677,000 43,980,000 40,836,000 38,439,000 32,441,000 33,246,000 29,624,000 24,109,000 
      general and administrative
    34,591,000 41,628,000 46,653,000 54,650,000 37,757,000 31,833,000 31,408,000 29,199,000 28,290,000 22,874,000 19,838,000 19,488,000 21,199,000 21,074,000 15,690,000 13,854,000 8,937,000 
      total operating costs and expenses
    134,977,000 177,377,000 195,450,000 206,113,000 124,436,000 114,960,000 110,134,000 110,083,000 92,732,000 81,999,000 74,658,000 75,733,000      
      income from operations
    -128,505,000 -172,202,000 -176,227,000 -191,368,000 -98,354,000 -100,543,000 -96,340,000 -99,550,000 -81,715,000 -69,865,000 -60,982,000 -62,573,000 -66,191,000 -55,981,000 -46,402,000 -40,929,000 -30,484,000 
      yoy
    30.66% 71.27% 82.92% 92.23% 20.36% 43.91% 57.98% 59.09% 23.45% 24.80% 31.42% 52.88% 117.13%     
      qoq
    -25.38% -2.28% -7.91% 94.57% -2.18% 4.36% -3.22% 21.83% 16.96% 14.57% -2.54% -5.47% 18.24% 20.64% 13.37% 34.26%  
      operating margin %
    -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      other income
    6,397,000 9,952,000 4,330,000 -11,277,000 2,679,000 2,480,000 4,188,000 6,533,000 4,989,000 4,538,000 3,490,000 2,128,000 631,000 2,000    
      loss before income tax benefit
    -122,108,000 -162,250,000 -171,897,000 -202,645,000 -95,675,000 -98,063,000 -92,152,000           
      income tax benefit
    4,604,000 -3,000  158,000 -167,000 523,000 779,000           
      net income
    -117,504,000 -162,253,000 -171,897,000 -202,487,000    -93,017,000 -76,726,000 -65,327,000 -57,492,000 -60,445,000 -65,560,000 -55,979,000 -47,428,000   
      yoy
       117.69%    53.89% 17.03% 16.70% 21.22%       
      qoq
    -27.58% -5.61% -15.11%     21.23% 17.45% 13.63% -4.89% -7.80% 17.12% 18.03%    
      net income margin %
    -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% 
      per share data
                     
      net income per share
    -0.22 -0.36 -0.41 -0.5 -0.34 -0.4 -0.39 -0.43 -0.38 -0.34 -0.3 -0.35 -0.38 -0.33 -0.28 -0.31 -1.33 
      weighted-average shares (class a, b and exchangeable) outstanding, basic and diluted
    529,303,984 446,988,046 417,361,147 402,771,972 282,583,048 242,196,409 236,019,349 214,327,186 201,415,475         
      net loss and comprehensive loss
        -95,842,000 -97,540,000 -91,373,000          -30,717,000 
      weighted-average shares (class a and b) outstanding, basic and diluted
             191,618,238 175,537,487 173,435,970 172,212,390 170,690,392 168,533,550 138,360,646  
      total costs and operating expenses
                73,865,000 61,314,000    
      operating expenses
                     
      total operating expenses
                  48,936,000 43,478,000 33,046,000 
      other loss
                  -1,026,000 -2,472,000 -233,000 
      net income and comprehensive loss
                   -43,401,000  
      weighted-average shares of common stock, basic and diluted
                    23,035,623 
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-09-30 2025-06-30 2025-03-31 2024-09-30 2024-06-30 2024-03-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-09-30 2021-06-30 2021-03-31 
                       
        assets
                       
        current assets
                       
        cash and cash equivalents
      654,473,000 659,836,000 525,110,000 500,453,000 427,647,000 474,341,000 296,326,000 387,322,000 405,870,000 473,145,000 549,912,000 454,646,000 453,875,000 507,891,000 394,721,000 632,738,000 214,088,000 
        restricted cash
      5,511,000 3,136,000 3,106,000 3,075,000 1,555,000 1,783,000 3,195,000 2,256,000 3,325,000 1,311,000 1,280,000 2,090,000 1,901,000 1,521,000 10,233,000 10,232,000 5,042,000 
        other receivables
      13,585,000 21,910,000 21,606,000 46,124,000 2,255,000 2,526,000 2,599,000 3,164,000 3,051,000 2,057,000 2,753,000 11,635,000 11,659,000 11,363,000 2,248,000   
        prepaid data assets
      11,742,000   2,470,000              
        other current assets
      24,246,000 29,223,000 37,338,000 32,023,000 42,715,000 43,725,000 41,495,000 17,780,000 18,774,000 15,612,000 15,869,000 13,247,000 16,979,000 15,432,000 9,445,000 4,616,000 2,621,000 
        total current assets
      709,557,000 714,105,000 587,160,000 584,145,000 474,172,000 522,375,000 343,615,000 410,522,000 431,020,000 492,125,000 569,814,000 481,618,000 545,996,000 619,455,000 600,870,000 647,635,000 221,822,000 
        restricted cash, non-current
      5,196,000 4,173,000 5,629,000 5,629,000 6,629,000 6,629,000 6,629,000 7,629,000 7,629,000 7,920,000 7,920,000 8,154,000 8,334,000 8,713,000    
        property and equipment
      95,811,000 111,706,000 120,038,000 126,834,000 84,410,000 83,633,000 86,716,000 86,248,000 89,768,000 90,004,000 88,192,000 85,777,000 81,508,000 70,704,000 55,439,000 48,549,000 44,642,000 
        operating lease right-of-use assets
      42,816,000 47,812,000 50,324,000 53,186,000 47,882,000 44,088,000 35,501,000 34,062,000 34,899,000 35,116,000 33,255,000 33,726,000 34,643,000 33,301,000    
        financing lease right-of-use assets
      18,694,000 21,726,000 23,242,000 24,757,000 26,897,000 28,562,000            
        intangible assets
      294,073,000 322,344,000 341,319,000 335,790,000 34,093,000 38,210,000 33,076,000 39,459,000 42,757,000 1,318,000 1,306,000 1,457,000 1,233,000 1,309,000 2,262,000 2,338,000 2,414,000 
        goodwill
      160,170,000 162,042,000 164,270,000 158,112,000 52,056,000 52,056,000 52,056,000 52,750,000 60,516,000 801,000 801,000 801,000 801,000 801,000    
        deferred tax assets
      957,000 957,000 957,000 2,003,000              
        other assets, non-current
      12,248,000 14,661,000 9,416,000 14,778,000 360,000 308,000 254,000 155,000 110,000 82,000        
        total assets
      1,339,522,000 1,399,526,000 1,302,355,000 1,305,234,000 726,499,000 775,861,000 557,847,000 630,825,000 666,699,000 627,366,000 701,288,000 611,533,000 672,515,000 734,319,000 658,606,000 698,590,000 271,943,000 
        liabilities and stockholders’ equity
                       
        current liabilities
                       
        accounts payable
      20,348,000 13,935,000 19,314,000 25,086,000 2,260,000 3,762,000 5,115,000 4,265,000 2,086,000 4,247,000 4,586,000 3,890,000 3,176,000 4,162,000 6,326,000 3,196,000 3,125,000 
        accrued expenses and other liabilities
      54,205,000 53,102,000 64,280,000 56,804,000 40,597,000 33,401,000 26,070,000 39,806,000 32,873,000 25,041,000 32,904,000 26,757,000 24,361,000 23,118,000 25,113,000 12,710,000 11,085,000 
        unearned revenue
      32,794,000 47,364,000 39,690,000 39,651,000 49,579,000 32,204,000 36,618,000 43,997,000 73,105,000 57,761,000 56,726,000 46,753,000 63,781,000 54,247,000    
        operating lease liabilities
      13,087,000 11,525,000 11,732,000 11,853,000 8,233,000 8,607,000 6,062,000 5,355,000 5,219,000 4,440,000 5,952,000 5,541,000 5,242,000 4,086,000    
        notes payable and financing lease liabilities
      9,265,000 8,919,000 8,752,000 8,587,000 8,219,000 8,109,000            
        total current liabilities
      129,699,000 155,103,000 164,026,000 141,981,000 108,888,000 86,083,000 73,920,000 94,118,000 113,959,000 92,150,000 100,265,000 83,036,000 96,653,000 85,705,000 42,943,000 29,540,000 26,854,000 
        unearned revenue, non-current
      114,723,000 111,204,000 126,243,000 129,609,000 15,712,000 29,169,000 37,391,000 51,383,000 32,436,000 57,091,000 70,261,000 93,909,000 89,934,000 107,121,000    
        operating lease liabilities, non-current
      42,842,000 50,028,000 53,395,000 56,024,000 53,663,000 50,239,000 43,786,000 44,300,000 45,850,000 46,771,000 44,420,000 45,993,000 47,763,000 47,317,000    
        notes payable and financing lease liabilities, non-current
      7,181,000 11,902,000 14,196,000 16,446,000 20,510,000 22,921,000            
        deferred tax liabilities
      18,283,000 23,312,000 23,784,000 22,437,000 168,000  528,000 1,931,000 4,336,000         
        other liabilities, non-current
      2,025,000 1,029,000 1,565,000 4,790,000 2,999,000 3,000,000            
        total liabilities
      314,753,000 352,578,000 383,209,000 371,287,000 201,940,000 191,412,000 156,696,000 192,858,000 197,736,000 197,191,000 215,482,000 223,499,000 234,936,000 240,753,000 59,574,000 55,876,000 56,662,000 
        commitments and contingencies
                       
        stockholders’ equity
                       
        common stock, 0.00001 par value...
      5,000 5,000 4,000 4,000 3,000 3,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000    
        additional paid-in capital
      3,191,608,000 2,980,729,000 2,681,111,000 2,553,492,000 1,776,933,000 1,740,981,000 1,460,144,000 1,312,591,000 1,250,570,000 1,135,056,000 1,125,360,000 970,096,000 959,393,000 949,932,000 934,175,000 930,431,000 11,287,000 
        accumulated deficit
      -2,193,506,000 -1,967,879,000 -1,805,589,000 -1,633,694,000 -1,252,377,000 -1,156,535,000 -1,058,995,000 -874,626,000 -781,609,000 -704,883,000 -639,556,000 -582,064,000 -521,619,000 -456,059,000 -335,147,000 -287,719,000 -244,318,000 
        accumulated other comprehensive income
      26,662,000 34,093,000 43,620,000 14,145,000           2,000   
        total stockholders’ equity
      1,024,769,000 1,046,948,000 919,146,000 933,947,000 524,559,000 584,449,000 401,151,000 437,967,000 468,963,000 430,175,000 485,806,000 388,034,000 437,579,000 493,566,000 599,032,000 642,714,000  
        total liabilities and stockholders’ equity
      1,339,522,000 1,399,526,000 1,302,355,000 1,305,234,000 726,499,000 775,861,000 557,847,000 630,825,000 666,699,000 627,366,000 701,288,000 611,533,000 672,515,000 734,319,000    
        accrued data liability
       20,258,000 20,258,000               
        notes payable
            55,000 695,000 676,000 661,000 97,000 95,000 93,000 92,000    
        notes payable, non-current
            1,071,000 1,126,000 1,155,000 1,179,000 536,000 561,000 586,000 610,000    
        accounts receivable
                  21,000 34,000 34,000 49,000 71,000 
        investments
                  61,561,000 83,214,000 184,189,000   
        other non-current assets
                   36,000 35,000 68,000 3,065,000 
        lease incentive obligation
                       
        deferred rent
                    3,348,000 2,819,000 2,750,000 
        lease incentive obligation, non-current
                       
        accumulated other comprehensive loss
                  -197,000 -309,000    
        liabilities, convertible preferred stock and stockholders’ equity
                       
        current portion of unearned revenue
                    10,000,000 10,000,000 10,000,000 
        current portion of notes payable
                    88,000 3,135,000 2,145,000 
        current portion of lease incentive obligation
                    1,416,000 499,000 499,000 
        unearned revenue, net of current portion
                    9,167,000 11,667,000 14,167,000 
        notes payable, net of current portion
                    656,000 9,423,000 10,339,000 
        lease incentive obligation, net of current portion
                    3,460,000 2,427,000 2,552,000 
        convertible preferred stock (series a, a-1, b, c and d), 0.00001 par value...
                       
        common stock (class a and b), 0.00001 par value...
                    2,000 2,000  
        total liabilities, convertible preferred stock and stockholders’ equity
                    658,606,000 698,590,000  
        convertible preferred stock (series a, a-1, b, c, and d), 0.00001 par value...
                      448,312,000 
        liabilities, convertible preferred stock and stockholders’ deficit
                       
        stockholders’ deficit
                       
        total stockholders’ deficit
                      -233,031,000 
        total liabilities, convertible preferred stock and stockholders’ deficit
                      271,943,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-09-30 2025-06-30 2025-03-31 2024-09-30 2024-06-30 2024-03-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-09-30 2021-06-30 2021-03-31 
                         
          cash flows from operating activities
                         
          net loss
        -117,504,000 -162,253,000 -171,897,000 -202,487,000 -95,842,000 -97,540,000 -91,373,000 -93,017,000 -76,726,000 -65,327,000    -55,979,000   -30,717,000 
          adjustments to reconcile net loss to net cash from operating activities:
                         
          depreciation and amortization
        19,673,000 21,043,000 23,849,000 19,331,000 7,198,000 8,968,000 7,377,000 7,578,000 5,543,000 3,728,000  2,989,000 2,786,000 2,767,000 2,436,000 2,331,000 1,402,000 
          stock-based compensation
        22,215,000 25,243,000 26,159,000 36,058,000 18,253,000 16,524,000 16,127,000 16,792,000 11,811,000 8,814,000  8,907,000 5,675,000 5,632,000 3,363,000 5,317,000 1,821,000 
          asset impairment
         5,956,000 108,000           
          lease expense
        5,243,000 5,264,000 5,625,000 6,130,000 5,580,000 3,103,000 2,472,000 2,023,000 2,003,000 1,988,000  1,990,000 2,015,000 1,742,000    
          loss on disposal of a business
         4,502,000              
          deferred income taxes
        -4,597,000                 
          other
        1,674,000 -2,443,000 4,693,000 4,405,000 2,920,000 -3,010,000 -560,000 -1,853,000 23,000 716,000  -217,000 192,000 402,000 464,000 2,375,000 101,000 
          changes in operating assets and liabilities:
                         
          other receivables and assets
        14,746,000 3,529,000 25,407,000 4,839,000 -939,000 736,000 -1,040,000 -203,000 -814,000 -317,000  3,777,000 -1,800,000 -7,551,000    
          prepaid data assets
         2,470,000 27,131,000              
          unearned revenue
        -2,248,000 -6,631,000 -13,621,000 -9,762,000 3,917,000 -12,636,000 -13,655,000 -10,160,000 -11,066,000 -12,134,000  -13,053,000 -7,653,000 144,701,000 -2,500,000 -2,500,000 -2,500,000 
          accounts payable
        2,070,000 -5,890,000 -4,837,000 3,692,000 -1,513,000 -1,342,000 1,168,000 2,186,000 -2,517,000 -339,000  714,000 -986,000 1,344,000 3,130,000 71,000 2,051,000 
          accrued development expense
        730,000 -4,055,000 -754,000 599,000 -445,000 -1,905,000 -273,000 -1,356,000 1,071,000 676,000  819,000 1,464,000 1,413,000 918,000 1,822,000 -1,216,000 
          accrued expenses and other current liabilities
        -18,451,000 -8,033,000 11,378,000 -26,591,000 6,349,000 7,507,000 -18,857,000 7,579,000 6,203,000 -9,846,000        
          lease liabilities
        -4,652,000 -5,216,000 -5,148,000 -5,760,000              
          net cash from operating activities
        -81,101,000 -117,360,000 -76,418,000 -131,957,000 -59,225,000 -82,219,000 -102,300,000 -72,920,000 -67,467,000 -73,316,000  -54,541,000 -61,623,000 77,388,000 -33,048,000 -33,653,000 -30,755,000 
          capital expenditures
        -258,000 -243,000 -3,150,000 -1,832,000 -4,562,000 -1,182,000 -6,653,000 -745,000 -3,968,000 -5,175,000  -8,263,000 -16,475,000 -4,342,000 -9,706,000 -6,212,000 -19,416,000 
          free cash flows
        -81,359,000 -117,603,000 -79,568,000 -133,789,000 -63,787,000 -83,401,000 -108,953,000 -73,665,000 -71,435,000 -78,491,000  -62,804,000 -78,098,000 73,046,000 -42,754,000 -39,865,000 -50,171,000 
          cash flows from investing activities
                         
          purchases of property and equipment
        -258,000 -243,000 -3,150,000 -1,832,000 -4,562,000 -1,182,000 -6,653,000 -745,000 -3,968,000 -5,175,000  -8,263,000 -16,475,000 -4,342,000 -9,706,000 -6,212,000 -19,416,000 
          purchase of an intangible asset
        -80,000     -82,000 -165,000        
          decrease in cash related to disposal of a business
         -4,438,000              
          purchases of investments
         -2,306,000 -500,000 -1,000,000              
          net cash from investing activities
        -338,000 -2,549,000 -5,808,000 -7,270,000 -4,562,000 -4,182,000 -6,653,000 -347,000 -2,053,000 -5,340,000  52,984,000 4,940,000 143,304,000 -193,873,000 -6,212,000 -19,416,000 
          cash flows from financing activities
                         
          proceeds from issuance of common shares, net of issuance costs
         254,460,000 100,000,000 41,024,000 16,968,000 261,546,000 10,873,000           
          equity incentive plans
        -1,262,000                 
          repayment of long-term debt and finance lease liabilities
        -2,208,000 -2,127,000 -2,084,000 -2,047,000              
          net cash from financing activities
        -3,470,000 251,340,000 97,659,000 40,527,000 16,462,000 263,122,000 13,897,000 53,765,000 3,787,000 1,922,000  2,337,000 2,668,000 2,084,000 -11,095,000 463,705,000 2,134,000 
          effect of exchange rate changes on cash, cash equivalents and restricted cash
        -3,832,000 1,869,000 9,255,000 4,833,000 403,000 -118,000 -219,000 -115,000 181,000 -2,000        
          net change in cash, cash equivalents and restricted cash
        -88,741,000 133,300,000 24,688,000 -93,867,000 -46,922,000 176,603,000 -95,275,000 -19,617,000 -65,552,000 -76,736,000  780,000 -54,015,000 222,776,000 -238,016,000 423,840,000 -48,037,000 
          cash, cash equivalents and restricted cash, beginning of period
        753,921,000 603,024,000 401,425,000 559,112,000  295,349,000 267,167,000 
          cash, cash equivalents and restricted cash, end of period
        665,180,000 133,300,000 24,688,000 509,157,000 -46,922,000 176,603,000 306,150,000 -19,617,000 -65,552,000 482,376,000  780,000 -54,015,000 518,125,000 -238,016,000 423,840,000 219,130,000 
          supplemental schedule of non-cash investing and financing activities
                         
          accrued property and equipment
         -234,000 -883,000 1,146,000 -313,000 469,000 80,000  -238,000 244,000  -1,081,000 -154,000 4,328,000 -350,000 58,000 705,000 
          purchase of an equity investment
         4,438,000              
          acquired ipr&d
                         
          accrued data liability
                        
          proceeds from equity incentive plans
         -993,000 2,743,000 1,550,000 1,781,000 1,602,000 3,050,000 3,789,000 3,811,000 1,946,000  2,360,000 2,690,000 2,106,000    
          issuance of shares for the acquisition of an asset
                         
          net cash and restricted cash acquired in the acquisition of a business
                        
          sales and maturities of investments
                   61,547,000 21,415,000 147,646,000    
          issuance of shares for the acquisitions of businesses
               -7,766,000          
          financed equipment purchase
               1,214,000        
          operating lease liabilities
             -2,624,000 -3,794,000 -2,508,000 -2,998,000 -2,444,000  -2,115,000 -1,547,000 -1,265,000    
          repayment of long-term debt
             -26,000 -26,000 -24,000 -24,000 -24,000  -23,000 -22,000 -22,000 -12,737,000 -20,000 -20,000 
          right-of-use asset additions and modifications
              3,266,000 164,000 640,000 3,520,000  -40,000      
          supplemental schedule of cash flow information
                         
          cash paid for operating leases
              3,955,000 2,508,000 2,998,000 2,444,000  2,115,000 1,547,000 1,265,000    
          fixed asset impairment
               19,000 1,169,000       
          proceeds from private placement of stock
                         
          cash paid for interest
               11,000 12,000 13,000  14,000 14,000 14,000 125,000 286,000 254,000 
          cash from operating activities
                         
          cash from investing activities
                         
          cash from financing activities
                         
          description of the matter
                         
          how we addressed the matter in our audit
                         
          loss on debt extinguishment
                         
          accrued expenses, deferred rent and other current liabilities
                   2,093,000 1,070,000 -15,903,000 10,126,000 -136,000 1,133,000 
          proceeds from initial public offering of common stock, net of issuance costs
                        
          conversion of preferred stock to common stock
                        
          deferred issuance costs recorded in equity
                        
          net income
                         
          adjustments to reconcile net income to net cash from operating activities:
                         
          right-of-use asset additions
                     1,548,000    
          accounts receivable
                      16,000 13,000 85,000 
          acquisition of a business
                         
          proceeds from note receivable
                         
          proceeds from sale of preferred stock, net of issuance costs
                         
          proceeds from convertible notes
                         
          supplemental disclosure of non—cash investing and financing information
                         
          conversion of convertible notes to equity
                         
          supplemental disclosure of cash flow information
                         
          other assets
                       455,000 -2,915,000 
          proceeds from exercise of stock options
                       824,000 2,154,000 
          deferred issuance costs
                        2,997,000