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Schrdinger, Inc.
(NASDAQ:SDGR) 

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Schrdinger, Inc. provides physics-based software platform that enables discovery of novel molecules for drug development and materials applications. The company operates through two segments, Software and Drug Discovery. The Software segment is focused on selling its software for drug discovery in t...

Founded: 1990
Full Time Employees: 392
CEO: Ramy Farid  
Sector: Healthcare
Industry: Health Information Services

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At a glance:
  • AI-Driven Computational Drug Discovery Platform: Schrödinger provides a physics-based molecular simulation software platform used to accelerate drug discovery and materials design, combining computational chemistry with machine learning.
  • Dual Revenue Model: Software + Drug Discovery Pipeline: The company generates revenue from software subscriptions/licensing and also operates an internal drug discovery effort with partnered and proprietary programs that can create longer-dated upside but adds R&D spend.
  • High R&D Investment and Operating Loss Profile: Schrödinger typically reinvests heavily in R&D to expand its platform and advance its pipeline, which has historically contributed to operating losses and negative free cash flow.
  • Partnerships Are Key Catalysts: Strategic collaborations with biopharma and industrial partners can drive software adoption, milestone payments, and validation of the platform’s predictive capabilities.
  • Catalysts and Risks Tied to Pipeline Progress and Market Adoption: Near- to mid-term performance is often influenced by pipeline readouts, partnering activity, and enterprise software demand, while risks include long development timelines, customer budget cycles, and competitive AI drug discovery offerings.
Bull Thesis:
  • Industry-Leading Computational Platform: Schrödinger possesses a highly differentiated and scientifically validated computational platform that significantly accelerates drug discovery and materials science. Its advanced physics-based modeling and machine learning capabilities are increasingly recognized as essential tools for reducing R&D costs and timelines across the pharmaceutical and biotech industries.
  • Secular Shift Towards In Silico Drug Discovery: The broader pharmaceutical industry is undergoing a fundamental shift towards integrating computational methods ('in silico') earlier and more extensively in the drug discovery process. Schrödinger is exceptionally well-positioned to capitalize on this secular trend, as companies seek to improve efficiency and success rates in their pipelines.
  • Robust Partnership and Internal Pipeline Model: The company's hybrid business model, combining recurring software revenue with drug discovery collaborations and an internal pipeline, offers multiple avenues for growth. Successful progression of partnered or wholly-owned drug candidates (e.g., through milestones and royalties) could unlock substantial value and further validate the power of their platform.
  • Strong Recurring Software Revenue Base: A significant portion of Schrödinger's revenue comes from high-margin, recurring software subscriptions. This provides a stable and predictable revenue base that can fund ongoing R&D and sales efforts, while also demonstrating customer stickiness and the essential nature of their tools.
Bear Thesis:
  • High Valuation and Path to Profitability Concerns: Despite its innovative technology, Schrödinger has historically traded at a premium valuation relative to its current revenue and profitability. The company continues to report negative free cash flow and net losses, raising questions about the timeline and path to sustainable profitability, especially in a higher interest rate environment.
  • Reliance on Long-Term Drug Discovery Success: A substantial portion of Schrödinger's future value is tied to the success of its drug discovery collaborations and internal pipeline. Drug development is inherently high-risk, long-duration, and capital-intensive, meaning significant returns from these ventures may be years away and are subject to clinical trial failures.
  • Competitive Landscape and Adoption Pace: While a leader, Schrödinger faces competition from other computational chemistry providers, internal R&D efforts within large pharma, and emerging AI/ML drug discovery platforms. The pace of adoption for new computational methods, while growing, can still be slower than anticipated in a traditionally conservative industry.
  • Significant Cash Burn and R&D Expenses: Schrödinger continues to invest heavily in research and development to maintain its technological edge and expand its pipeline, leading to a substantial cash burn. If revenue growth from software and drug discovery milestones does not accelerate sufficiently, the company may face pressure on its balance sheet or require further capital raises.
Main Competitors:
  • Dassault Systèmes ($DSY.PA) (BIOVIA (e.g., Discovery Studio, Materials Studio)), Offers a comprehensive suite of scientific software for molecular modeling, simulation, cheminformatics, and lab management. BIOVIA directly competes with Schrödinger's platform by providing tools for in silico drug discovery, materials science, and process optimization across various industries.
  • Cadence Design Systems ($CDNS) (OpenEye Scientific Software (e.g., OMEGA, ROCS, VIDA)), Cadence acquired OpenEye Scientific, a direct competitor in molecular modeling and cheminformatics. OpenEye's software suite is particularly strong in ligand-based and structure-based drug design, offering alternative computational chemistry solutions to Schrödinger's platform.
  • Certara, Inc. ($CERT) (Simcyp, Phoenix, D360), Certara provides a platform of biosimulation and regulatory science software, including tools for ADME/PK modeling and drug discovery. While broader in scope, it competes by offering integrated computational approaches that aim to accelerate drug development from discovery through clinical trials.
  • Gaussian, Inc. (Gaussian, GaussView), Gaussian, Inc. is a leading provider of quantum chemistry software for molecular electronic structure calculations. It competes at the fundamental level of physics-based simulations that are critical for understanding molecular properties and reactions, underpinning much of drug and materials design.
Moat:
Schrödinger's competitive advantage is rooted in its highly accurate, physics-based computational platform that integrates quantum mechanics, molecular dynamics, and machine learning to accelerate drug discovery and materials design. Competition primarily comes from other software vendors offering similar computational chemistry/biology tools, broader scientific software platforms, and specialized solutions for specific R&D challenges. Key competitive factors include the accuracy and breadth of simulation capabilities, integration with experimental workflows, ease of use, and the ability to demonstrate significant acceleration and cost reduction in R&D processes. The market also sees indirect competition from AI-first drug discovery companies, some of which may develop proprietary computational platforms or utilize a combination of commercial and in-house tools.
Income Statements:
Quarterly
Annual
    Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 
                             
      revenues:
                             
      software products and services
    69,282,000 40,858,000 40,544,000 48,816,000 79,662,000 31,884,000 35,404,000 33,415,000 68,655,000 28,904,000 29,352,000 32,213,000 47,819,000 24,667,000 30,011,000 33,081,000 38,564,000 24,280,000 24,052,000 26,340,000 24,957,000 22,861,000 20,900,000 23,812,000  
      drug discovery
    17,953,000 13,466,000 14,215,000 10,735,000 8,655,000 3,406,000 11,930,000 3,183,000 5,471,000 13,665,000 5,837,000 32,569,000 9,024,000 12,313,000 8,458,000 15,582,000 7,606,000 5,570,000 5,732,000 5,787,000 8,075,000 2,936,000 2,192,000 2,362,000  
      total revenues
    87,235,000 54,324,000 54,759,000 59,551,000 88,317,000 35,290,000 47,334,000 36,598,000 74,126,000 42,569,000 35,189,000 64,782,000 56,843,000 36,980,000 38,469,000 48,663,000 46,170,000 29,850,000 29,784,000 32,127,000 33,032,000 25,797,000 23,092,000 26,174,000  
      yoy
    -1.23% 53.94% 15.69% 62.72% 19.14% -17.10% 34.51% -43.51% 30.40% 15.11% -8.53% 33.12% 23.12% 23.89% 29.16% 51.47% 39.77% 15.71% 28.98% 22.74%      
      qoq
    60.58% -0.79% -8.05% -32.57% 150.26% -25.44% 29.33% -50.63% 74.13% 20.97% -45.68% 13.97% 53.71% -3.87% -20.95% 5.40% 54.67% 0.22% -7.29% -2.74% 28.05% 11.71% -11.78%   
      cost of revenues:
                             
      total cost of revenues
    29,942,000 26,285,000 28,601,000 28,427,000 24,187,000 17,562,000 15,999,000 17,708,000 16,576,000 18,930,000 21,379,000 19,089,000 18,139,000 19,779,000 21,335,000 20,680,000 19,809,000 18,735,000 17,804,000 15,963,000 14,040,000 10,525,000 9,509,000 10,549,000  
      gross profit
    57,293,000 28,039,000 26,158,000 31,124,000 64,130,000 17,728,000 31,335,000 18,890,000 57,550,000 23,639,000 13,810,000 45,693,000 38,704,000 17,201,000 17,134,000 27,983,000 26,361,000 11,115,000 11,980,000 16,164,000 18,992,000 15,272,000 13,583,000 15,625,000  
      yoy
    -10.66% 58.16% -16.52% 64.76% 11.43% -25.01% 126.90% -58.66% 48.69% 37.43% -19.40% 63.29% 46.82% 54.75% 43.02% 73.12% 38.80% -27.22% -11.80% 3.45%      
      qoq
    104.33% 7.19% -15.96% -51.47% 261.74% -43.42% 65.88% -67.18% 143.45% 71.17% -69.78% 18.06% 125.01% 0.39% -38.77% 6.15% 137.17% -7.22% -25.88% -14.89% 24.36% 12.43% -13.07%   
      gross margin %
    65.68% 51.61% 47.77% 52.26% 72.61% 50.24% 66.20% 51.61% 77.64% 55.53% 39.25% 70.53% 68.09% 46.51% 44.54% 57.50% 57.10% 37.24% 40.22% 50.31% 57.50% 59.20% 58.82% 59.70%  
      operating expenses:
                             
      research and development
    41,399,000 42,757,000 43,138,000 45,844,000 49,362,000 50,977,000 50,835,000 50,611,000 51,487,000 46,833,000 42,705,000 40,741,000 34,542,000 32,885,000 31,123,000 27,822,000 25,145,000 23,219,000 21,092,000 21,448,000 17,319,000 17,019,000 16,657,000 13,700,000  
      sales and marketing
    10,338,000 9,524,000 10,734,000 10,367,000 9,704,000 10,349,000 9,693,000 10,171,000 9,950,000 9,109,000 9,022,000 9,145,000 9,382,000 7,161,000 7,428,000 6,671,000 5,975,000 5,556,000 5,380,000 5,239,000 4,675,000 3,969,000 4,362,000 4,789,000  
      general and administrative
    22,713,000 21,705,000 25,189,000 25,802,000 25,776,000 24,824,000 23,536,000 25,541,000 25,734,000 23,890,000 23,216,000 26,308,000 23,318,000 23,318,000 22,056,000 22,133,000 17,756,000 17,014,000 15,850,000 13,389,000 13,582,000 9,729,000 9,651,000 8,936,000  
      total operating expenses
    74,450,000 73,986,000 79,061,000 82,013,000 84,842,000 86,150,000 84,064,000 86,323,000 87,171,000 79,832,000 74,943,000 76,194,000 67,242,000 63,364,000 60,607,000 56,626,000 48,876,000 45,789,000 42,322,000 40,076,000 35,576,000 30,717,000 30,670,000 27,425,000  
      income from operations
    -17,157,000 -45,947,000 -52,903,000 -50,889,000 -20,712,000 -68,422,000 -52,729,000 -67,433,000 -29,621,000 -56,193,000 -61,133,000 -30,501,000 -28,538,000 -46,163,000 -43,473,000 -28,643,000 -22,515,000 -34,674,000 -30,342,000 -23,912,000 -16,584,000 -15,445,000 -17,087,000 -11,800,000  
      yoy
    -17.16% -32.85% 0.33% -24.53% -30.08% 21.76% -13.75% 121.08% 3.79% 21.73% 40.62% 6.49% 26.75% 33.13% 43.28% 19.79% 35.76% 124.50% 77.57% 102.64%      
      qoq
    -62.66% -13.15% 3.96% 145.70% -69.73% 29.76% -21.81% 127.65% -47.29% -8.08% 100.43% 6.88% -38.18% 6.19% 51.78% 27.22% -35.07% 14.28% 26.89% 44.19% 7.37% -9.61% 44.81%   
      operating margin %
    -19.67% -84.58% -96.61% -85.45% -23.45% -193.88% -111.40% -184.25% -39.96% -132.00% -173.73% -47.08% -50.20% -124.83% -113.01% -58.86% -48.77% -116.16% -101.87% -74.43% -50.21% -59.87% -74.00% -45.08%  
      other income:
                             
      gain on equity investments
            -109,000   147,322,000  -3,000 11,828,000      -48,000  4,156,000   
      change in fair value of equity investments
    46,999,000 9,691,000 4,579,000 -13,095,000                      
      other income
    3,131,000 3,623,000 5,438,000 4,204,000 3,539,000 4,737,000 4,598,000 5,028,000 6,626,000 5,804,000 4,326,000 2,937,000 2,687,000 1,231,000 -296,000           
      total other income
    50,130,000 13,314,000 10,017,000 -8,891,000 -18,541,000 30,196,000 -1,235,000 13,165,000 -1,891,000 -8,718,000 44,980,000 185,996,000 1,194,000 6,501,000 -4,168,000 -5,836,000 -7,926,000 -341,000 -4,561,000 23,463,000 5,223,000 18,696,000 13,085,000   
      income before income taxes
    32,973,000 -32,633,000 -42,886,000 -59,780,000 -39,253,000 -38,226,000 -53,964,000 -54,268,000 -31,512,000 -64,911,000 -16,153,000 155,495,000 -27,344,000 -39,662,000 -47,641,000 -34,479,000 -30,441,000 -35,015,000 -34,903,000 -449,000 -11,361,000 3,251,000 -4,002,000 -14,180,000  
      income tax provision
    462,000 162,000 287,000 28,000 963,000 -90,000 83,000 456,000 -842,000 -2,887,000 -20,431,000 26,359,000 -136,000 194,000 33,000 -28,000 274,000 -4,000 67,000 74,000 225,000 -35,000 64,000 91,000  
      net income
    32,511,000 -32,795,000 -43,173,000 -59,808,000 -40,216,000 -38,136,000 -54,047,000 -54,724,000 -30,670,000 -62,024,000 4,278,000 129,136,000 -27,208,000 -39,856,000 -47,674,000 -34,451,000 -30,715,000 -35,011,000 -34,970,000 -523,000 -11,586,000 3,286,000 -4,066,000 -14,271,000  
      yoy
    -180.84% -14.01% -20.12% 9.29% 31.12% -38.51% -1363.37% -142.38% 12.72% 55.62% -108.97% -474.84% -11.42% 13.84% 36.33% 6487.19% 165.10% -1165.46% 760.06% -96.34%      
      qoq
    -199.13% -24.04% -27.81% 48.72% 5.45% -29.44% -1.24% 78.43% -50.55% -1549.84% -96.69% -574.63% -31.73% -16.40% 38.38% 12.16% -12.27% 0.12% 6586.42% -95.49% -452.59% -180.82% -71.51%   
      net income margin %
    37.27% -60.37% -78.84% -100.43% -45.54% -108.06% -114.18% -149.53% -41.38% -145.70% 12.16% 199.34% -47.87% -107.78% -123.93% -70.80% -66.53% -117.29% -117.41% -1.63% -35.08% 12.74% -17.61% -54.52%  
      net income per share
    0.44 -0.45 -0.59 -0.82 -0.55 -0.52 -0.74 -0.76 -0.43 -0.86 0.06 1.81 -0.39 -0.56 -0.67 -0.48 -0.43 -0.49 -0.49  -0.18 0.06 -0.05 -0.34  
      weighted-average shares used for eps calculation
    73,443,298 73,613,090 73,427,635 73,057,916 72,670,295 72,813,006 72,711,685 72,291,134 71,776,301 71,924,451 71,642,722 71,467,097 71,173,419 71,207,992 71,161,892 71,050,432 70,594,950 70,784,184 70,582,062 70,071,625 60,024,658 66,339,570 63,296,366 40,666,970  
      change in fair value
        -22,080,000 25,459,000 -5,833,000 8,137,000 -8,408,000 -14,522,000 40,654,000 35,737,000 -1,493,000 5,273,000 -15,700,000 -6,164,000 -7,920,000 -627,000 -4,918,000 24,824,000 4,750,000 18,233,000 8,359,000 -3,079,000  
      net loss attributable to noncontrolling interest
                -1,000 -3,000  -11,000 -2,000 -4,000 -326,000 -494,000 -447,000 -566,000 -716,000 -445,000  
      net loss attributable to schrödinger common and limited common stockholders
                -27,207,000 -39,853,000 -47,686,000 -34,440,000   -34,644,000 -29,000   -3,350,000 -13,826,000  
      net income attributable to noncontrolling interest
                  12,000           
      loss on equity investments
                       -1,781,000      
      interest income
                   328,000 -6,000 286,000 357,000 420,000 521,000 463,000 570,000 699,000  
      net income attributable to schrödinger common and limited common stockholders
                    -17,420,000 -35,007,000   -3,331,000 3,852,000    
      total other expense
                           -2,380,000  
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 
                               
        current assets:
                               
        cash and cash equivalents
      230,517,000 172,120,000 219,901,000 325,997,000 147,326,000 160,416,000 108,109,000 130,236,000 155,315,000 249,378,000 285,963,000 233,206,000 90,474,000 102,817,000 127,319,000 117,257,000 120,267,000 160,879,000 117,699,000 133,122,000 202,296,000 210,490,000 110,380,000 144,749,000 25,986,000 
        restricted cash
      6,868,000 9,753,000 12,079,000 11,764,000 15,331,000 9,760,000 4,227,000 4,638,000 5,751,000 6,230,000 5,053,000 4,486,000 5,243,000 5,803,000 3,500,000 3,500,000 3,000,000 3,000,000 3,000,000 500,000 500,000 500,000 500,000 500,000 500,000 
        marketable securities
      164,947,000 219,113,000 230,284,000 174,301,000 204,798,000 228,263,000 269,180,000 300,843,000 307,688,000 246,905,000 262,710,000 294,482,000 360,613,000 370,739,000 382,246,000 408,275,000 456,212,000 436,307,000 495,892,000 515,372,000 440,395,000 388,494,000 173,646,000 143,505,000 59,844,000 
        accounts receivable
      83,041,000 29,384,000 10,073,000 20,347,000 235,692,000 13,281,000 11,849,000 19,839,000 65,992,000 19,884,000 9,652,000 46,691,000 55,953,000 23,583,000 18,767,000 29,321,000 31,744,000 11,352,000 21,359,000 11,270,000 31,423,000 12,290,000 13,849,000 16,272,000 18,676,000 
        unbilled and other receivables, net of allowance for unbilled receivables of 140 and 100
      21,352,000 28,016,000 26,711,000                       
        prepaid expenses
      12,540,000 13,336,000 14,947,000 12,562,000 12,205,000 13,136,000 15,493,000 12,349,000 9,926,000 13,111,000 13,999,000 11,396,000 8,569,000 9,104,000 12,062,000 11,542,000 5,030,000 5,509,000 7,293,000 7,954,000 4,409,000 4,449,000 5,294,000 5,881,000 6,468,000 
        total current assets
      519,265,000 471,722,000 513,995,000 570,944,000 634,993,000 456,398,000 449,179,000 493,686,000 567,796,000 547,761,000 591,962,000 603,734,000 533,989,000 524,201,000 556,872,000 586,168,000 625,060,000 622,025,000 649,788,000 675,238,000 682,978,000 621,114,000 307,014,000 312,815,000 118,536,000 
        property and equipment
      19,456,000 20,738,000 21,709,000 22,937,000 24,196,000 24,922,000 25,723,000 26,133,000 23,325,000 22,498,000 20,353,000 16,493,000 14,244,000 13,755,000 11,524,000 11,120,000 10,025,000 9,074,000 6,985,000 4,799,000 5,140,000 5,296,000 5,837,000 6,488,000 6,268,000 
        equity investments
      73,647,000 44,382,000 34,691,000 30,113,000 43,208,000 65,216,000 88,555,000 91,387,000 83,251,000 91,863,000 106,404,000 101,539,000 25,683,000 27,177,000 21,903,000 37,002,000 43,167,000 51,087,000 49,713,000 52,931,000 45,664,000 40,914,000 22,680,000 15,156,000 15,366,000 
        goodwill
      4,791,000 4,791,000 4,791,000 4,791,000 4,791,000 4,791,000 4,791,000 4,791,000 4,791,000 4,791,000 4,791,000 4,791,000 4,791,000 4,791,000 4,791,000 4,791,000          
        right of use assets - operating leases
      102,736,000 105,107,000 107,346,000 109,661,000 111,883,000 112,816,000 116,525,000 118,578,000 117,778,000 119,822,000                
        other assets
      6,265,000 6,920,000 5,712,000 4,586,000 4,155,000 5,153,000 3,598,000 3,187,000 6,014,000 7,413,000 5,072,000 6,234,000 3,311,000 2,879,000 1,804,000 1,334,000 2,851,000 3,972,000 3,382,000 2,356,000 2,352,000 2,209,000 2,102,000 2,172,000 2,338,000 
        total assets
      726,160,000 653,660,000 688,244,000 743,032,000 823,226,000 669,296,000 688,371,000 737,762,000 802,955,000 794,148,000 841,566,000 838,773,000 688,587,000 661,985,000 687,880,000 719,537,000 756,487,000 762,617,000 717,334,000 744,189,000 746,263,000 680,116,000 349,551,000 349,872,000 155,270,000 
        liabilities and stockholders’ equity
                               
        current liabilities:
                               
        accounts payable
      11,452,000 9,218,000 8,800,000 11,861,000 10,666,000 11,210,000 8,116,000 9,974,000 16,815,000 10,318,000 12,428,000 11,987,000 9,470,000 10,918,000 5,263,000 9,766,000 8,079,000 8,228,000 5,960,000 7,220,000 8,398,000 4,812,000 5,523,000 6,675,000 3,524,000 
        accrued payroll, taxes, and benefits
      39,264,000 27,986,000 25,322,000 21,494,000 42,110,000 33,611,000 24,320,000 19,549,000 31,763,000 25,508,000 21,328,000 13,152,000 24,882,000 18,904,000 16,533,000 10,951,000 18,405,000 14,010,000 10,540,000 10,345,000 12,000,000 7,702,000 5,757,000 4,745,000  
        deferred revenue
      112,853,000 82,283,000 94,543,000 105,458,000 111,944,000 41,773,000 40,799,000 49,497,000 56,231,000 43,313,000 46,674,000 51,578,000 57,931,000 43,920,000 47,440,000 53,771,000 55,368,000 43,874,000 44,069,000 40,759,000 45,403,000 19,067,000 23,138,000 21,710,000 25,054,000 
        lease liabilities - operating leases
      16,412,000 16,740,000 16,841,000 16,755,000 16,755,000 16,887,000 16,801,000 16,927,000 16,868,000 16,279,000                
        other accrued liabilities
      9,155,000 8,886,000 10,263,000 9,904,000 10,272,000 7,636,000 9,723,000 10,560,000 11,996,000 8,536,000 7,317,000 8,562,000 5,510,000 6,396,000 9,174,000 6,893,000 7,317,000 4,826,000 7,289,000 5,721,000 2,861,000 2,204,000 2,791,000 3,185,000 3,824,000 
        total current liabilities
      189,136,000 145,113,000 155,769,000 165,472,000 191,747,000 111,117,000 99,759,000 106,507,000 133,673,000 105,038,000 106,802,000 123,407,000 108,799,000 88,821,000 85,590,000 85,532,000 91,211,000 72,916,000 70,378,000 67,621,000 73,205,000 39,276,000 43,048,000 42,166,000 45,020,000 
        deferred revenue, long-term
      78,877,000 92,390,000 91,995,000 104,496,000 108,814,000 5,200,000 7,080,000 8,016,000 9,043,000 12,102,000 15,620,000 20,348,000 25,598,000 21,977,000 20,105,000 24,582,000 30,064,000 32,444,000 34,457,000 37,356,000 41,164,000 2,592,000 1,979,000 2,125,000  
        lease liabilities - operating leases, long-term
      92,816,000 94,694,000 97,472,000 99,405,000 101,074,000 103,257,000 107,128,000 108,988,000 111,014,000 112,720,000                
        other liabilities, long-term
      1,278,000 111,000 136,000 155,000 146,000 297,000 424,000 545,000 667,000 707,000 600,000 700,000 800,000 900,000 1,000,000 1,400,000 300,000 300,000 300,000 600,000 654,000 600,000 600,000 900,000  
        total liabilities
      362,107,000 332,308,000 345,372,000 369,528,000 401,781,000 219,871,000 214,391,000 224,056,000 254,397,000 230,567,000 230,341,000 248,513,000 240,682,000 198,863,000 194,807,000 188,867,000 199,402,000 182,795,000 111,563,000 112,413,000 122,244,000 49,230,000 53,404,000 54,324,000 57,013,000 
        commitments and contingencies
                               
        stockholders' equity:
                               
        preferred stock, 0.01 par value. authorized 10,000,000 shares; zero shares issued and outstanding at december 31, 2025 and december 31, 2024, respectively
                               
        common stock
      645,000 645,000 644,000 642,000 637,000 637,000 636,000 635,000 630,000 628,000 627,000 623,000 622,000 620,000 620,000 620,000 618,000 617,000 616,000 613,000 607,000 563,000 501,000 501,000 61,000 
        limited common stock, 0.01 par value. authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at december 31, 2025 and december 31, 2024, respectively
      92,000                         
        additional paid-in capital
      992,015,000 981,853,000 970,687,000 958,029,000 946,037,000 933,424,000 920,621,000 906,193,000 885,973,000 871,100,000 856,913,000 840,446,000 828,700,000 818,015,000 807,827,000 797,004,000 786,964,000 778,292,000 769,199,000 760,574,000 752,558,000 748,123,000 417,032,000 414,248,000 11,655,000 
        accumulated deficit
      -628,806,000 -661,317,000 -628,522,000 -585,349,000 -525,541,000 -485,325,000 -447,189,000 -393,142,000 -338,418,000 -307,748,000 -245,724,000 -250,002,000 -379,138,000 -351,931,000 -312,078,000 -264,392,000 -229,952,000 -199,239,000 -164,232,000 -129,588,000 -129,559,000 -118,420,000 -122,272,000 -118,922,000 -105,096,000 
        accumulated other comprehensive income
      107,000 79,000 -29,000 90,000 220,000 597,000 -180,000 -72,000         -651,000 44,000 76,000 77,000 317,000 480,000 727,000 -442,000 16,000 
        total stockholders' equity
      364,053,000 321,352,000 342,872,000 373,504,000 421,445,000 449,425,000 473,980,000 513,706,000  563,581,000 611,225,000 590,260,000  463,122,000            
        total liabilities and stockholders' equity
      726,160,000 653,660,000 688,244,000 743,032,000 823,226,000 669,296,000 688,371,000 737,762,000  794,148,000 841,566,000 838,773,000  661,985,000            
        liabilities and stockholders' equity:
                               
        preferred stock, 0.01 par value. authorized 10,000,000 shares; zero shares issued and outstanding at september 30, 2025 and december 31, 2024, respectively
                               
        limited common stock, 0.01 par value. authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at september 30, 2025 and december 31, 2024, respectively
       92,000                        
        preferred stock, 0.01 par value. authorized 10,000,000 shares; zero shares issued and outstanding at june 30, 2025 and december 31, 2024, respectively
                               
        limited common stock, 0.01 par value. authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at june 30, 2025 and december 31, 2024, respectively
        92,000                       
        unbilled and other receivables, net of allowance for unbilled receivables of 120 and 100
         25,973,000                      
        preferred stock, 0.01 par value. authorized 10,000,000 shares; zero shares issued and outstanding at march 31, 2025 and december 31, 2024, respectively
                               
        limited common stock, 0.01 par value. authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at march 31, 2025 and december 31, 2024, respectively
         92,000                      
        unbilled and other receivables, net of allowance for unbilled receivables of 100 and 100
          19,641,000                     
        preferred stock, 0.01 par value. authorized 10,000,000 shares; zero shares issued and outstanding at december 31, 2024 and december 31, 2023, respectively
                               
        limited common stock, 0.01 par value. authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at december 31, 2024 and december 31, 2023, respectively
          92,000                     
        unbilled and other receivables, net for allowance for unbilled receivables of 130 and 100
           31,542,000 40,321,000 25,781,000                  
        preferred stock, 0.01 par value. authorized 10,000,000 shares; zero shares issued and outstanding at september 30, 2024 and december 31, 2023, respectively
                               
        limited common stock, 0.01 par value. authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at september 30, 2024 and december 31, 2023, respectively
           92,000                    
        preferred stock, 0.01 par value. authorized 10,000,000 shares; zero shares issued and outstanding at june 30, 2024 and december 31, 2023, respectively
                               
        limited common stock, 0.01 par value. authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at june 30, 2024 and december 31, 2023, respectively
            92,000                   
        preferred stock, 0.01 par value. authorized 10,000,000 shares; zero shares issued and outstanding at march 31, 2024 and december 31, 2023, respectively
                               
        limited common stock, 0.01 par value. authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at march 31, 2024 and december 31, 2023, respectively
             92,000                  
        unbilled and other receivables, net for allowance for unbilled receivables of 100 and 100
              23,124,000 12,253,000 14,585,000 13,473,000              
        intangible assets
                  587,000 720,000 853,000 986,000          
        stockholders’ equity:
                               
        preferred stock, 0.01 par value. authorized 10,000,000 shares; zero shares issued and outstanding at december 31, 2023 and december 31, 2022, respectively
                               
        limited common stock, 0.01 par value. authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at december 31, 2023 and december 31, 2022, respectively
              92,000                 
        accumulated other comprehensive loss
              281,000 -491,000 -683,000 -899,000 -2,382,000 -3,686,000 -3,403,000 -2,657,000          
        total stockholders’ equity of schrödinger stockholders
              548,558,000    447,894,000  493,058,000 530,667,000 557,071,000 579,806,000 605,751,000 631,768,000      
        noncontrolling interest
                  11,000 12,000 15,000 3,000 14,000 16,000 20,000 8,000 4,000 8,000 27,000 31,000 41,000 
        total stockholders’ equity
              548,558,000    447,905,000  493,073,000 530,670,000 557,085,000 579,822,000 605,771,000 631,776,000 624,019,000 630,886,000 296,147,000 295,548,000  
        total liabilities and stockholders’ equity
              802,955,000    688,587,000  687,880,000 719,537,000 756,487,000 762,617,000 717,334,000 744,189,000      
        income taxes payable
               1,084,000 5,134,000 26,318,000              
        preferred stock, 0.01 par value. authorized 10,000,000 shares; zero shares issued and outstanding at september 30, 2023 and december 31, 2022, respectively
                               
        limited common stock, 0.01 par value. authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at september 30, 2023 and december 31, 2022, respectively
               92,000                
        right of use assets
                112,984,000 105,982,000 105,982,000 88,462,000 90,133,000 78,136,000 75,384,000 76,459,000 7,466,000 8,865,000 10,129,000 10,583,000 11,918,000 13,241,000 12,762,000 
        lease liabilities
                13,921,000 11,810,000 11,006,000 8,683,000 7,180,000 4,151,000 2,042,000 1,978,000 2,520,000 3,576,000 4,543,000 5,491,000 5,839,000 5,851,000 5,584,000 
        lease liabilities, long-term
                107,319,000 104,058,000 105,485,000 87,165,000 88,112,000 77,353,000 77,827,000 77,135,000 6,428,000 6,836,000 7,221,000 6,762,000 7,777,000 9,133,000  
        preferred stock, 0.01 par value. authorized 10,000,000 shares; zero shares issued and outstanding at june 30, 2023 and december 31, 2022, respectively
                               
        limited common stock, 0.01 par value. authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at june 30, 2023 and december 31, 2022, respectively
                92,000               
        preferred stock, 0.01 par value. authorized 10,000,000 shares; zero shares issued and outstanding at march 31, 2023 and december 31, 2022, respectively
                               
        limited common stock, 0.01 par value. authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at march 31, 2023 and december 31, 2022, respectively
                 92,000              
        unbilled and other receivables, net for allowance for unbilled receivables of 100 and 30
                  13,137,000             
        preferred stock, 0.01 par value. authorized 10,000,000 shares; zero shares issued and outstanding at december 31, 2022 and december 31, 2021, respectively
                               
        limited common stock, 0.01 par value. authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at december 31, 2022 and december 31, 2021, respectively
                  92,000             
        unbilled and other receivables, net for allowance for unbilled receivables of 40 and 30
                   12,155,000 12,978,000 16,273,000          
        preferred stock, 0.01 par value. authorized 10,000,000 shares; zero shares issued and outstanding at september 30, 2022 and december 31, 2021, respectively
                               
        limited common stock, 0.01 par value. authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at september 30, 2022 and december 31, 2021, respectively
                   92,000            
        total stockholders' equity of schrödinger stockholders
                   463,110,000            
        preferred stock, 0.01 par value. authorized 10,000,000 shares; zero shares issued and outstanding at june 30, 2022 and december 31, 2021
                               
        limited common stock, 0.01 par value. authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at june 30, 2022 and december 31, 2021
                    92,000           
        preferred stock, 0.01 par value. authorized 10,000,000 shares; zero shares issued and outstanding at march 31, 2022 and december 31, 2021
                               
        limited common stock, 0.01 par value. authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at march 31, 2022 and december 31, 2021
                     92,000          
        unbilled and other receivables, net for allowance for unbilled receivables of 30 and 0
                      8,807,000         
        preferred stock, 0.01 par value. authorized 10,000,000 shares; zero shares issued and outstanding at december 31, 2021 and december 31, 2020, respectively
                               
        limited common stock, 0.01 par value. authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at december 31, 2021 and december 31, 2020, respectively
                      92,000         
        unbilled and other receivables, net for allowance for unbilled receivables of 20 and 0
                       4,978,000 4,545,000 7,020,000      
        preferred stock, 0.01 par value. authorized 10,000,000 shares; zero shares issued and outstanding at september 30, 2021 and december 31, 2020, respectively
                               
        limited common stock, 0.01 par value. authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at september 30, 2021 and december 31, 2020, respectively
                       92,000        
        preferred stock, 0.01 par value. authorized 10,000,000 shares; zero shares issued and outstanding at june 30, 2021 and december 31, 2020, respectively
                               
        limited common stock, 0.01 par value. authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at june 30, 2021 and december 31, 2020, respectively
                        92,000       
        preferred stock, 0.01 par value. authorized 10,000,000 shares; zero shares issued and outstanding at march 31, 2021 and december 31, 2020, respectively
                               
        limited common stock, 0.01 par value. authorized 100,000,000 shares; 9,164,193 shares issued and outstanding at march 31, 2021 and december 31, 2020, respectively
                         92,000      
        unbilled and other receivables
                          3,955,000 4,891,000 3,345,000 1,908,000  
        liabilities, convertible preferred stock, and stockholders’ equity
                               
        convertible preferred stock:
                               
        series e convertible preferred stock, 0.01 par value. authorized zero and 77,150,132 shares; zero and 73,795,777 shares issued and outstanding at december 31, 2020 and december 31, 2019, respectively
                               
        series d convertible preferred stock, 0.01 par value. authorized zero and 39,540,611 shares; zero and 39,540,611 shares issued and outstanding at december 31, 2020 and december 31, 2019, respectively
                               
        series c convertible preferred stock, 0.01 par value. authorized zero and 47,242,235 shares; zero and 47,242,235 shares issued and outstanding at december 31, 2020 and december 31, 2019, respectively
                               
        series b convertible preferred stock, 0.01 par value. authorized zero and 29,468,101 shares; zero and 29,468,101 shares issued and outstanding at december 31, 2020 and december 31, 2019, respectively
                               
        series a convertible preferred stock, 0.01 par value. authorized zero and 134,704,785 shares; zero and 134,704,785 shares issued and outstanding at december 31, 2020 and december 31, 2019, respectively
                               
        total convertible preferred stock
                              191,580,000 
        stockholders’ equity
                               
        limited common stock, 0.01 par value. authorized 100,000,000 and 146,199,885 shares; 9,164,193 and zero shares issued and outstanding at december 31, 2020 and december 31, 2019, respectively
                          92,000     
        total stockholders’ equity (deficit) of schrödinger stockholders
                          624,015,000 630,878,000 296,120,000 295,517,000  
        total liabilities, convertible preferred stock, and stockholders’ equity
                          746,263,000 680,116,000 349,551,000 349,872,000  
        series e convertible preferred stock, 0.01 par value. authorized zero and 77,150,132 shares; zero and 73,795,777 shares issued and outstanding at september 30, 2020 and december 31, 2019, respectively
                               
        series d convertible preferred stock, 0.01 par value. authorized zero and 39,540,611 shares; zero and 39,540,611 shares issued and outstanding at september 30, 2020 and december 31, 2019, respectively
                               
        series c convertible preferred stock, 0.01 par value. authorized zero and 47,242,235 shares; zero and 47,242,235 shares issued and outstanding at september 30, 2020 and december 31, 2019, respectively
                               
        series b convertible preferred stock, 0.01 par value. authorized zero and 29,468,101 shares; zero and 29,468,101 shares issued and outstanding at september 30, 2020 and december 31, 2019, respectively
                               
        series a convertible preferred stock, 0.01 par value. authorized zero and 134,704,785 shares; zero and 134,704,785 shares issued and outstanding at september 30, 2020 and december 31, 2019, respectively
                               
        stockholders' equity
                               
        limited common stock, 0.01 par value. authorized 100,000,000 and 146,199,885 shares; 13,164,193 and zero shares issued and outstanding at september 30, 2020 and december 31, 2019, respectively
                           132,000    
        series e convertible preferred stock, 0.01 par value. authorized zero and 77,150,132 shares; zero and 73,795,777 shares issued and outstanding at june 30, 2020 and december 31, 2019, respectively
                               
        series d convertible preferred stock, 0.01 par value. authorized zero and 39,540,611 shares; zero and 39,540,611 shares issued and outstanding at june 30, 2020 and december 31, 2019, respectively
                               
        series c convertible preferred stock, 0.01 par value. authorized zero and 47,242,235 shares; zero and 47,242,235 shares issued and outstanding at june 30, 2020 and december 31, 2019, respectively
                               
        series b convertible preferred stock, 0.01 par value. authorized zero and 29,468,101 shares; zero and 29,468,101 shares issued and outstanding at june 30, 2020 and december 31, 2019, respectively
                               
        series a convertible preferred stock, 0.01 par value. authorized zero and 134,704,785 shares; zero and 134,704,785 shares issued and outstanding at june 30, 2020 and december 31, 2019, respectively
                               
        limited common stock, 0.01 par value. authorized 100,000,000 and 146,199,885 shares; 13,164,193 and zero shares issued and outstanding at june 30, 2020 and december 31, 2019, respectively
                            132,000   
        series e convertible preferred stock, 0.01 par value. authorized zero and 77,150,132 shares; zero and 73,795,777 shares issued and outstanding at march 31, 2020 and december 31, 2019, respectively
                               
        series d convertible preferred stock, 0.01 par value. authorized zero and 39,540,611 shares; zero and 39,540,611 shares issued and outstanding at march 31, 2020 and december 31, 2019, respectively
                               
        series c convertible preferred stock, 0.01 par value. authorized zero and 47,242,235 shares; zero and 47,242,235 shares issued and outstanding at march 31, 2020 and december 31, 2019, respectively
                               
        series b convertible preferred stock, 0.01 par value. authorized zero and 29,468,101 shares; zero and 29,468,101 shares issued and outstanding at march 31, 2020 and december 31, 2019, respectively
                               
        series a convertible preferred stock, 0.01 par value. authorized zero and 134,704,785 shares; zero and 134,704,785 shares issued and outstanding at march 31, 2020 and december 31, 2019, respectively
                               
        limited common stock, 0.01 par value. authorized 100,000,000 and 146,199,885 shares; 13,164,193 and zero shares issued and outstanding at march 31, 2020 and december 31, 2019, respectively
                             132,000  
        unbilled receivables and other receivables
                              7,062,000 
        liabilities, convertible preferred stock, and stockholders’ deficit
                               
        accrued payroll, taxes and benefits
                              7,034,000 
        deferred revenue, long term
                              2,205,000 
        deferred rent, long term
                               
        lease liabilities, long term
                              8,888,000 
        other liabilities, long term
                              900,000 
        series e convertible preferred stock, 0.01 par value. authorized, 67,087,074 shares; 73,795,777 shares issued and outstanding; liquidation preference of 110,000
                              109,270,000 
        series d convertible preferred stock, 0.01 par value. authorized, 39,540,611 shares; 39,540,611 shares issued and outstanding; liquidation preference of 22,000
                              22,000,000 
        series c convertible preferred stock, 0.01 par value. authorized, 47,242,235 shares; 47,242,235 shares issued and outstanding, liquidation preference of 20,000
                              19,844,000 
        series b convertible preferred stock, 0.01 par value. authorized, 29,468,101 shares; 29,468,101 shares issued and outstanding; liquidation preference of 10,000
                              9,840,000 
        series a convertible preferred stock, 0.01 par value. authorized, 134,704,785 shares; 134,704,785 shares issued and outstanding; liquidation preference of 18,185
                              30,626,000 
        stockholders' deficit:
                               
        total stockholders’ deficit of schrödinger stockholders
                              -93,364,000 
        total stockholders’ deficit
                              -93,323,000 
        total liabilities, convertible preferred stock, and stockholders’ deficit
                              155,270,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 
                                
          cash flows from operating activities:
                                
          net income
            -40,216,000 -38,136,000 -54,047,000 -54,724,000 -30,670,000 -62,024,000 4,278,000 129,136,000             
          adjustments to reconcile net income to net cash from operating activities:
                                
          gain on equity investments
                 -147,322,000         48,000   
          changes in fair value of equity investments
                                
          depreciation and amortization
        1,437,000 1,465,000 1,531,000 1,589,000 1,764,000 1,558,000 1,401,000 1,436,000 1,354,000 1,273,000 1,165,000 1,760,000 1,142,000 1,107,000 1,126,000 969,000         
          stock-based compensation
        9,950,000 10,846,000 10,627,000 11,574,000 12,479,000 12,398,000 12,808,000 12,218,000 12,534,000 12,654,000 11,773,000 10,880,000 10,205,000 9,864,000 10,427,000 9,134,000 7,456,000 7,652,000 7,016,000 4,366,000 3,003,000 3,038,000 2,729,000 1,775,000 
          noncash investment accretion
        480,000 -671,000 -815,000 -861,000  -1,554,000 -2,023,000 -2,683,000         534,000 2,393,000 388,000 1,955,000 287,000 564,000 -288,000 83,000 
          loss on disposal of property and equipment
          1,000   2,000 77,000   5,000 18,000 -4,000 121,000 19,000     
          decrease in assets:
                                
          accounts receivable
        -53,657,000 -19,311,000 10,274,000 215,345,000 -222,411,000 -1,432,000 7,990,000 46,153,000 -46,108,000 -10,232,000 37,039,000 9,262,000 -32,370,000 -4,816,000 10,554,000 2,935,000 -20,392,000 10,007,000 -10,089,000 20,153,000 -19,133,000 1,559,000 2,423,000 2,404,000 
          unbilled and other receivables
        6,664,000 -1,305,000 -738,000 -6,332,000 11,901,000 8,779,000 -14,540,000 -2,657,000 -10,871,000 2,332,000 -1,112,000 -336,000 -981,000 823,000 3,295,000 -7,390,000 -3,829,000 -433,000 2,140,000 -3,065,000 888,000 -1,546,000 -1,028,000 5,154,000 
          reduction in the carrying amount of right of use assets - operating leases
        2,371,000 2,239,000 2,315,000 2,222,000 1,028,000 3,709,000 2,053,000 2,152,000 2,044,000                
          prepaid expenses and other assets
        1,451,000 403,000 -3,511,000 -788,000 1,832,000 804,000 -3,559,000 -2,559,000 4,586,000 -1,640,000 -5,658,000 -5,750,000 -230,000 1,882,000 -994,000 -7,725,000 1,599,000 1,194,000 -365,000 -3,549,000 -103,000 737,000 659,000 -1,106,000 
          increase in liabilities:
                                
          accounts payable
        2,210,000 435,000 -3,081,000 1,344,000 -677,000 3,499,000 -1,791,000 -7,150,000 6,579,000 550,000 -2,276,000 2,468,000 -1,418,000 5,535,000 -4,266,000 1,328,000 -182,000 2,260,000 -1,259,000 -1,230,000 3,628,000 -745,000 -111,000 2,110,000 
          accrued payroll, taxes, and benefits
        11,278,000 2,664,000 3,828,000 -20,616,000 8,499,000 9,291,000 4,771,000 -12,214,000 6,255,000 4,180,000 8,176,000 -11,730,000 5,978,000 2,371,000 5,582,000 -7,454,000 4,395,000 3,470,000 195,000 -1,655,000 4,298,000 1,945,000 1,012,000 -2,289,000 
          deferred revenue
        17,057,000 -11,865,000 -23,416,000 -10,804,000 173,785,000 -906,000 -9,634,000 -7,761,000 9,858,000 -6,879,000 -9,632,000 -11,603,000 17,632,000 -1,648,000 -10,808,000 -7,079,000 9,162,000 -2,160,000 417,000 -8,447,000 64,963,000 -3,285,000 1,405,000 -3,378,000 
          lease liabilities - operating leases
        -2,206,000 -2,879,000 -1,847,000 -1,669,000 -2,315,000 -3,785,000 -1,986,000 -1,967,000 -1,117,000                
          other accrued liabilities
        1,360,000 -1,408,000 367,000 -228,000 2,470,000 -2,023,000 -1,006,000 -1,383,000 3,310,000 391,000 -1,286,000 3,502,000 -1,172,000 -2,986,000 2,223,000 637,000 1,879,000 -2,463,000 1,268,000 2,806,000 712,000 -588,000 -696,000 -638,000 
          net cash from operating activities
        -16,093,000 -61,873,000 -52,198,000 144,063,000 -31,113,000 -33,256,000 -53,723,000 -39,276,000 -37,255,000 -49,941,000 -18,443,000 -31,094,000 -24,942,000 -30,363,000 -24,656,000 -39,722,000 -19,738,000 -10,638,000 -29,372,000 -10,921,000 43,618,000 -12,032,000 -9,051,000 -5,778,000 
          capital expenditures
        58,000 -509,000 -293,000 -558,000 -722,000 -1,940,000 -1,018,000 -3,312,000 -2,789,000 -6,923,000 234,000 -3,276,000 -1,191,000 -2,880,000 -2,211,000 -1,036,000 -311,000 -2,783,000 -2,914,000 -513,000 -886,000 -325,000 -484,000 -843,000 
          free cash flows
        -16,035,000 -62,382,000 -52,491,000 143,505,000 -31,835,000 -35,196,000 -54,741,000 -42,588,000 -40,044,000 -56,864,000 -18,209,000 -34,370,000 -26,133,000 -33,243,000 -26,867,000 -40,758,000 -20,049,000 -13,421,000 -32,286,000 -11,434,000 42,732,000 -12,357,000 -9,535,000 -6,621,000 
          cash flows from investing activities:
                                
          purchases of property and equipment
        -41,000 -491,000 -314,000 -596,000 -873,000 -1,342,000 -1,001,000 -4,095,000 -2,479,000 -4,917,000 -2,427,000 -3,580,000 -1,346,000 -2,998,000 -1,974,000 -1,696,000 -957,000 -2,783,000 -2,914,000 -513,000 -886,000 -325,000 -484,000 -843,000 
          purchases of equity investments
            -72,000   -4,125,000   -2,000,000   -2,869,000 
          distribution from equity investment
                77,000 19,000 35,788,000 111,329,000 -3,000   335,000 40,000   
          proceeds from sale and disposition of equity investments
                                
          purchases of marketable securities
        -69,252,000 -77,645,000 -138,506,000 -27,556,000 -63,873,000 -33,953,000 -116,387,000 -37,126,000 -96,111,000 -98,799,000 -66,891,000 -58,823,000 -68,097,000 -92,160,000 -56,147,000 -55,068,000 -74,293,000 -117,784,000 -79,054,000 -143,671,000 -72,852,000 -269,122,000 -50,585,000 -127,109,000 
          proceeds from maturity of marketable securities
        122,966,000 89,595,000 83,219,000 58,784,000 88,293,000 77,201,000 149,966,000 46,300,000 38,899,000 116,900,000 100,773,000 127,401,000 81,000,000 103,001,000 81,215,000 99,495,000  174,943,000 98,145,000 66,500,000     
          net cash from investing activities
        71,408,000 11,459,000 -55,601,000 30,632,000 23,475,000 90,704,000 29,578,000 5,079,000 -59,614,000 13,203,000 67,243,000 172,202,000 11,557,000 7,840,000 34,322,000 36,304,000 -22,091,000 52,376,000 14,812,000 -61,909,000 -53,238,000 -215,983,000 -24,587,000 -87,913,000 
          cash flows from financing activities:
                                
          proceeds from issuances of common stock upon stock option exercises
        212,000 321,000                       
          proceeds from issuance of common stock in atm offering
                                
          payment of offering costs
                -199,000               
          principal payments on finance leases
        -15,000 -14,000 -15,000 -14,000 -15,000 -14,000 -15,000 -14,000 -14,000                
          net cash from financing activities
        197,000 307,000 2,018,000 409,000 119,000 392,000 1,607,000 8,005,000 2,327,000 1,330,000 4,524,000 867,000 482,000 324,000 396,000 908,000 1,217,000 1,442,000 1,637,000 3,656,000 1,426,000 328,125,000 -731,000 212,454,000 
          net increase in cash and cash equivalents and restricted cash
        55,512,000 -50,107,000 -105,781,000 175,104,000 -7,519,000 57,840,000 -22,538,000 -26,192,000 -94,542,000 -35,408,000 53,324,000 141,975,000     -40,612,000 43,180,000 -12,923,000 -69,174,000 -8,194,000 100,110,000 -34,369,000 118,763,000 
          cash and cash equivalents and restricted cash, beginning of year
                                
          cash and cash equivalents and restricted cash, end of year
                                
          supplemental disclosure of non-cash investing and financing activities
                                
          purchases of property and equipment in accounts payable
        24,000 -18,000 21,000 13,000 132,000 -405,000 -66,000 501,000 -82,000 -2,661,000 2,717,000 218,000 -29,000 118,000 -237,000 317,000 646,000        
          purchases of property and equipment in accrued liabilities
        75,000   25,000 19,000 -193,000 49,000 282,000 -228,000 655,000 -56,000 86,000 184,000   343,000         
          acquisition of right of use assets - operating leases, contingency resolution
            2,848,000                
          acquisition of right of use assets in exchange for lease liabilities - operating leases
                                
          acquisition of right of use assets in exchange for lease liabilities - finance leases
                               
          net loss
         -32,795,000 -43,173,000 -59,808,000         -27,208,000 -39,856,000 -47,674,000 -34,451,000 -30,715,000 -35,011,000 -34,970,000 -523,000 -11,586,000 3,286,000 -4,066,000 -14,271,000 
          adjustments to reconcile net loss to net cash from operating activities:
                                
          loss on equity investments
                    3,000   1,781,000     
          fair value adjustments of equity investments
         -9,691,000 -4,579,000 13,095,000                     
          proceeds from disposition and sale of equity investments
                               
          cash and cash equivalents and restricted cash, beginning of period
         162,657,000  161,066,000  95,717,000  123,267,000  202,796,000  26,486,000 
          cash and cash equivalents and restricted cash, end of period
         -50,107,000 -105,781,000 337,761,000  57,840,000 -22,538,000 134,874,000  -35,408,000 53,324,000 237,692,000  -22,199,000 10,062,000 120,757,000  43,180,000 -12,923,000 133,622,000  100,110,000 -34,369,000 145,249,000 
          supplemental disclosure of cash flow and noncash information
                                
          cash paid for income taxes
         285,000 226,000 139,000 233,000 408,000 259,000 180,000 634,000 1,276,000 832,000 86,000 325,000 291,000 134,000 37,000 212,000 12,000 105,000 119,000 156,000 76,000 85,000 64,000 
          issuances of common stock upon stock option exercises
           423,000 134,000 406,000 558,000 392,000 2,341,000 1,534,000 4,698,000 867,000 482,000 324,000 396,000 908,000  1,442,000 1,612,000 3,656,000     
          issuance of common stock in atm offering
                                
          changes in fair value
                                
          noncash investment amortization
                -2,799,000   -964,000 -1,473,000 383,000 215,000 1,504,000         
          decrease in assets, net of acquisition:
                                
          increase in liabilities, net of acquisition:
                                
          acquisition, net of acquired cash
                    -6,427,000         
          acquisition of right of use assets - operating leases
                                
          acquisition of lease liabilities - operating leases
                                
          fair value adjustments
             -25,459,000 5,833,000 -8,137,000 8,408,000 14,522,000 -40,654,000 -35,737,000 1,493,000 -5,273,000 15,700,000 6,164,000 7,920,000 627,000 4,918,000 -24,824,000 -4,750,000 -18,233,000 -8,359,000 3,079,000 
          income taxes payable
                 -4,050,000 -21,184,000 25,963,000             
          issuance of common stock upon atm offering
             1,064,000 7,627,000                 
          accrued offering costs
                               786,000 
          noncash revenue from equity investments
                        -48,000 -48,000 -6,000 -5,000 -55,000 -173,000 -123,000 -46,000 
          noncash research and development expenses
                        313,000 498,000 443,000 547,000 712,000 435,000 
          proceeds from sale of equity investments
                        15,735,000     
          contribution by noncontrolling interest
                              
          acquisition of right of use assets - operating leases in exchange for lease liabilities - operating leases
                                
          noncash (accretion) investment amortization
                                
          reduction in the carrying amount of right of use assets
                    2,475,000 1,672,000 1,919,000 1,221,000 1,075,000 2,061,000 1,399,000 1,264,000 1,385,000 1,335,000 1,323,000 1,299,000 
          lease liabilities
                  -961,000 -623,000 980,000 556,000 -125,000 489,000 756,000 -889,000 -1,464,000 -1,352,000 -1,420,000 -1,363,000 -1,368,000 -1,266,000 
          acquisition of right to use assets, contingency resolution
                  -1,306,000 1,820,000 1,513,000         
          acquisition of right of use assets in exchange for lease liabilities
                                
          gain on disposal of property and equipment
                                
          acquisition of right of use assets
                     13,621,000 1,146,000         
          acquisition of lease liabilities
                    19,663,000 13,621,000 1,146,000         
          issuances of common stock upon initial public offering
                            -786,000 212,277,000 
          issuances of common stock upon follow-on public offering
                            -10,000    
          acquisitions of right of use assets
                                
          reclassification of deferred financing costs to additional paid-in capital
                                
          net decrease in cash and cash equivalents and restricted cash
                       -2,510,000         
          adjustments to reconcile net loss to net cash from
                                
          operating activities:
                                
          gain on lease termination
                                
          depreciation
                        652,000 581,000 727,000 887,000 1,010,000 890,000 881,000 877,000 
          proceeds from sale and maturity of marketable securities
                            20,500,000 53,464,000 21,900,000 42,908,000 
          issuances of series e preferred stock
                                
          issuances of common stock upon stock option exercise
                            1,436,000 2,515,000 55,000 177,000 
          deferred offering costs
                                
          accrued deferred offering costs
                                
          acquisitions of right of use assets in exchange for lease obligations
                           931,000 1,778,000 
          right of use assets recognized on adoption
                                
          reclassification of deferred financing costs to additional paid in capital
                                
          payment of deferred offering costs
                                
          reclass of deferred financing costs to additional paid in capital
                               
          noncash rent expense
                                
          other receivables
                                
          reduction in the carrying amount of right of use asset
                                
          issuances of common stock
                                
          noncash operating activities:
                                
          acquisition of right of use assets in exchange for lease obligations