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Unit: USD	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-12-31	2014-09-30	2014-06-30	2014-03-31	2013-09-30	2013-06-30	2013-03-31	2012-12-31	2012-09-30	2012-06-30	2012-03-31	2011-09-30	2011-06-30	2011-03-31	2010-12-31	2010-09-30	2010-06-30	2010-03-31	2009-12-31	2009-09-30	2009-06-30	2009-03-31	2008-12-31	2008-09-30	2008-06-30	2008-03-31	2007-12-31	2007-09-30	2007-06-30	2007-03-31	2006-12-31	2006-09-30	2006-06-30	2006-03-31	2005-12-31	2005-09-30	2005-06-30	2005-03-31	2004-12-31	2004-09-30	2004-06-30

cash flows for operating activities
net income	14,911,000	14,866,000	5,830,000	-33,869,000	2,940,000	3,321,000	2,094,000	-25,488,000	18,172,000	20,064,000	28,829,000	48,729,000	40,405,000	49,861,000	46,964,000	29,110,000	33,498,000	36,233,000	29,450,000	19,698,000	14,552,000	15,861,000	9,815,000	3,604,000	1,659,000	8,095,000	8,053,000	5,638,000	4,794,000	2,737,000	3,448,000		4,669,000	8,438,000	3,068,000		1,155,000	3,871,000	1,625,000						1,466,234			5,888,274			9,553,113	1,806,489	1,569,963	1,226,472	604,674	-55,597	-2,030,687	375,916	623,209	988,053		-348,938	-979,703	-1,105,980		18,382	142,056	8,278,828		-241,943						100,734	-819,646	-202,312	-467,508	2,186,326	-426,631	-193,228	-1,718,629	-645,086
adjustments to reconcile net income to net cash from operating activities:
depreciation and amortization	20,009,000	20,081,000	18,704,000	18,367,000	17,658,000	16,857,000	16,791,000	17,143,000	19,705,000	15,985,000	15,252,000	14,380,000	12,672,000	12,099,000	11,834,000	11,017,000	10,010,000	8,976,000	8,444,000	7,486,000	6,712,000	6,479,000	6,390,000	6,077,000	5,738,000	4,840,000	4,213,000	4,003,000	3,881,000	3,934,000	3,960,000	4,133,000	3,096,000	1,696,000	1,582,000	1,490,000	1,379,000	1,315,000	1,150,000	1,145,000	1,153,431	1,145,049	1,150,520	1,054,754	1,109,241	962,985	892,407	762,238	690,023	818,920	915,768	895,939	872,476	824,409	405,831	406,377	400,281	465,011	407,215	402,021	386,180	339,674	330,427	322,718		280,028	261,213	241,325		207,581	200,281	189,158	154,097	132,533	127,515	124,887	131,211	83,436	93,570	90,217	94,820	141,519	223,362	296,557
amortization of debt discount and issuance costs	4,202,000	4,119,000	4,039,000	3,960,000	3,901,000	3,918,000	3,809,000					455,000	455,000	453,000	452,000	2,938,000	2,902,000	2,862,000	2,828,000
inventory step-up amortization
stock-based compensation	8,973,000	8,375,000	7,273,000	6,359,000	23,721,000	9,214,000	8,776,000	6,465,000	6,373,000	5,483,000	7,254,000
deferred income taxes	-3,215,000	-1,365,000	-1,204,000	-12,627,000	-1,529,000	-1,801,000	-833,000	12,073,000	-7,560,000	-1,072,000	-1,124,000	-3,074,000	984,000	-307,000	1,045,000	446,000	805,000	4,477,000	789,000	-4,064,000	1,984,000
change in fair value of contingent consideration	-4,148,000
net unrealized foreign exchange gain	-190,000	-4,046,000	-8,207,000
operating lease right of use asset amortization	4,401,000	4,685,000	4,484,000
other adjustments and non-cash items
changes in operating assets and liabilities, excluding impact of acquisitions:
accounts receivable	7,856,000	-5,237,000	-9,921,000	-9,400,000	-3,386,000	-7,898,000	6,653,000	-11,627,000	12,921,000	12,226,000	-16,832,000	5,013,000	-176,000	-2,164,000	-6,269,000	5,404,000	-19,987,000	-12,161,000	-19,779,000	-9,505,000	-5,502,000	-3,614,000	-2,399,000	-992,000	583,000	-625,000	-6,692,000	-4,518,000	3,205,000	-3,259,000	-1,529,000	1,584,000	-2,125,000	-3,932,000	-2,415,000	48,000	-4,162,000	2,041,000	-1,149,000	-962,000	4,086,392	384,130	-7,237,522	-834,035	1,785,047	-2,453,751	-94,064	-1,304,116	1,957,338	-2,772,175	3,461,008	469,546	-3,779,819	-1,362,078	-1,498,658	-1,262,210	-88,428	924,832	-557,767	-968,206	-305,231	2,202,585	-2,027,400	100,787	1,161,519	1,780,341	-1,147,606	-1,273,432	2,322,554	-856,360	97,221	-1,545,522	833,914	-777,000	-92,357	-514,526	1,066,964	-605,241	257,173	-543,389	-132,661	-328,317	581,780	107,215
inventories	-4,522,000	3,004,000	-3,828,000	36,764,000	9,657,000	7,307,000	3,167,000	14,994,000	28,487,000	3,337,000	-5,845,000	7,104,000	-6,202,000	-28,069,000	-30,037,000	-28,183,000	-18,825,000	-25,748,000	-17,025,000	-6,493,000	-7,803,000	-7,773,000	-7,191,000	-4,423,000	-754,000	-2,659,000	-1,478,000	763,000	-1,709,000	-1,908,000	-1,188,000	-94,000	1,512,000	-1,664,000	851,000	294,000	-1,364,000	-2,001,000	-3,092,000	-2,098,000	-1,670,871	-1,866,486	-513,643	487,216	-1,061,079	-617,348	331,087	789,125	-511,388	872,260	-301,812	1,377,187	1,713,646	-54,782	232,704	-738,813	-16,406	99,293	181,814	-17,537	-97,669	171,004	-94,557	233,309	108,685	72,729	-124,995	334,601	-1,279,559	142,502	-35,996	-116,623	-424,971	-120,854	272,280	224,566	-98,293	-750,288	-220,361	236,664	55,826	116,482	-168,774	242,533
prepaid expenses and other current assets	-5,318,000	2,015,000	-2,191,000																										-1,293,000	1,464,000	-1,608,000		-503,000	-270,000	34,000	-208,000	27,000	12,000	781,000	-976,000	-282,580	667,368	314,212	-908,386	388,758	-90,731	-209,701	599,627	-283,465	-51,472	-216,827	8,808	532,193	-293,908	-264,942	-167,632	1,694,651	-969,354	80,652	180,391	140,959	-1,064,580	256,962	121,137	-152,164	-81,122	209,328	-202,280	76,631	-208,227	-133,695	3,359	61,778	-101,878	255,719	-108,792	-3,624	85,369	32,837	19,324	82,020	-137,295	132,528	-12,558
other noncurrent assets	-180,000	-345,000	-1,202,000
accounts payable	3,194,000	-1,584,000	-6,693,000	11,118,000	233,000	2,192,000	-645,000	-1,184,000	-4,748,000	-2,677,000	-1,194,000	1,927,000	-16,446,000	4,122,000	2,200,000	10,555,000	651,000	4,592,000	3,725,000	-855,000	433,000	3,593,000	-709,000	1,442,000	-1,275,000	1,065,000	-570,000	-1,088,000	4,055,000	849,000	-1,550,000	648,000	-1,581,000	2,192,000	-452,000	116,000	-2,429,000	2,111,000	-1,600,000	3,773,000	-1,335,581	151,689	434,892	1,366,757	-1,148,640	2,306,123	-236,176	-571,199	-409,366	-548,648	691,836	-897,555	931,040	276,225	-342,078	-8,076	231,420	-199,449	178,164	-270,539	164,216	-653,456	475,098	-917,425	268,901	988,820	-269,441	-1,787,617	1,847,315	-309,471	-246,275	268,836	675,019	-373,133	60,011	-266,838	428,623	-313,115	555,439	-621,460	507,900	-8,175	268,731	-465,789
accrued liabilities	12,624,000	-4,802,000	1,807,000																										2,915,000	-146,000	-3,839,000	4,096,000	-1,873,000	4,000	-4,220,000	-1,649,000	850,000	1,038,000	-4,277,000	-2,677,000	210,348	-505,061	1,379,713	-504,613	2,860,380	-845,140	-3,999,779	-1,087,086	1,893,182	-1,301,152	996,669	-152,086	278,410	960,971	779,164	-899,170	791,461	411,233	17,814	-837,271	255,484	609,216	422,978	-505,478	529,762	-232,053	612,241	-108,571	-416,603			-274,578	-718,243	1,154,226	-84,613	-4,951	-590,411	629,465	-152,477	-214,382
operating lease liabilities	-2,292,000	-4,968,000	-4,836,000		-29,716,000	1,383,000	22,484,000		-3,132,000	-1,674,000	-2,870,000		2,305,000
noncurrent liabilities	637,000	-219,000	475,000
total cash from operating activities	48,099,000	28,609,000	15,005,000	39,176,000	49,320,000	42,190,000	44,708,000	29,065,000	39,231,000	34,468,000	11,154,000	61,882,000	41,367,000	45,721,000	23,113,000	49,620,000	22,483,000	37,651,000	9,262,000	14,871,000	21,489,000	16,735,000	9,530,000	17,674,000	21,965,000	17,789,000	9,788,000
cash flows from investing activities
acquisitions, net of cash acquired	0	-234,000	-69,720,000					-158,799,000	256,000							-28,914,000	-121,050,000	0	71,000	-146,596,000
additions to capitalized software costs	-684,000	-504,000	-867,000	-1,448,000	-155,000	-2,592,000	-27,000	-30,000	-661,000	-1,151,000	-924,000	-944,000	-693,000	-848,000	-1,027,000	-1,242,000	-754,000	-707,000	-1,484,000	-304,000	-1,359,000	-1,315,000	-911,000	-20,000	-1,348,000	-1,542,000	-1,740,000
purchases of property, plant and equipment	-4,702,000	-7,101,000	-3,563,000	-5,540,000	-6,983,000	-4,808,000	-8,346,000	-11,087,000	-8,386,000	-8,240,000	-8,509,000	-20,444,000	-11,814,000	-25,372,000	-27,204,000	-32,120,000	-10,891,000	-16,494,000	-7,584,000	-11,388,000	-3,776,000	-3,165,000	-4,126,000	-7,091,000	-5,566,000	-3,759,000	-2,088,000	-2,055,000	-4,168,000	-2,848,000	-1,564,000	-1,768,000	-1,010,000	-1,381,000	-1,295,000	-863,000	-2,056,000	-975,000	-431,000	-573,000	-318,305	-464,899	-1,271,796	-2,638,439	-1,740,017	-627,303	-596,788	-2,669,630	-783,118	-322,099	-438,586	-311,546	-356,773	-156,742	-170,632	-168,002	-206,684	-163,233	-90,794	-63,955	-156,512	-90,908	-224,499	-125,430		-290,279	-130,552	-332,727		-237,172	-178,903	-195,016	-116,150	-186,503	-438,981	-584,895	-177,212	-314,544	-145,005	-98,734	-28,257	-14,079	-1,050	-9,272
sale of property, plant and equipment	0	0	42,000												17,000
other investing activities						0	11,000	11,000				80,000	13,000
total cash from investing activities	-7,783,000	-7,839,000	-74,108,000	-64,762,000	-5,859,000	-7,400,000	-8,362,000	-169,905,000	-8,770,000	64,833,000	-9,433,000	-121,308,000	-57,494,000	-26,220,000	-28,214,000	-62,276,000	-132,695,000	-17,201,000	-8,997,000	-158,288,000	-33,580,000	-4,480,000	-5,037,000	-7,111,000	-6,892,000	-187,477,000	-3,828,000
cash flows from financing activities
proceeds from exercise of stock options	678,000	0	1,464,000	1,928,000	578,000	843,000	945,000	720,000	294,000	33,000	29,000	923,000	2,321,000	167,000	296,000		1,131,000	352,000	508,000
payment of tax withholding obligation on vesting of restricted stock	-824,000	-676,000	-6,494,000		-546,000	-1,235,000	-7,622,000	-1,049,000	-1,038,000	-1,548,000	-9,592,000	-1,189,000	-1,070,000	-2,448,000	-12,311,000	-1,645,000				0	0	0	-10,000	-200,000
repayment of convertible senior notes				0					-24,000			-8,000	0	-12,000	-6,000		-1,000	-7,000	-1,000
payment of earnout consideration	-93,000			0	0	-5,215,000	-2,160,000	0	0
total cash from financing activities	-239,000	-10,131,000	-5,030,000	1,449,000	-69,604,000	-5,773,000	-8,974,000	268,127,000	-778,000	-8,825,000	-9,563,000	-274,000	1,251,000	-2,293,000	-12,021,000	231,000	-122,000	345,000	507,000	298,838,000	1,676,000	3,813,000	1,589,000	-180,000	294,875,000	190,128,000	44,000
effect of exchange rate changes on cash and cash equivalents	-185,000	987,000	4,007,000	-2,472,000	961,000	-488,000	1,922,000	-6,743,000	-2,560,000																				-1,703,000	-2,526,000	-224,000	-257,000	580,000	1,517,000	536,000	-1,967,000	-306,000	-1,435,000	1,409,000	45,000	-373,227	876,563	-2,430,336	-1,871,954	-2,005,284	-800,728	-78,163	580,211	-350,578	-141,985	177,788	579,054	-318,013	163,694
net increase in cash and cash equivalents	39,892,000	11,626,000	-60,126,000	-26,609,000	-25,182,000	28,529,000	29,294,000	120,544,000	27,123,000																					1,735,000	117,000	14,093,000	17,459,000	12,544,000	7,430,000	-35,418,000	-14,971,000	119,409,000	-879,000	6,008,000	8,071,976	8,801,548	-4,152,524	-543,837	2,151,143	-15,453,903	9,379,968	4,912,842	8,761,563	-639,806	10,819,844	2,509,971	3,087,107	1,625,154			4,409,035	-5,368,781			7,207,140	-1,766,630	3,414,926	-1,370,806	-9,946,433	-12,134,918	-6,335,606	896,229	16,641,883	-22,495,476			2,438,257	-191,048	138,549	-87,730								144,279
cash and cash equivalents, beginning of period																																0	0	0	122,233,000	0	0	0	54,092,000	0	-24	0	35,363,024	0	0	0	39,829,653	0	0	29,209,821	0	0	0	11,167,745	0	14,203,544	0	0	0	12,526,040	0	0	0	5,041,410	0	0	0	32,562,138	0	0	0	7,726,505	0	0	0	5,428,477		0	0	3,216,681		0	0	3,958,677
cash and cash equivalents, end of period	39,892,000	11,626,000	697,229,000	-26,609,000	-25,182,000	28,529,000	780,617,000	120,544,000	27,123,000	87,047,000	516,609,000	-49,905,000	-23,149,000	11,872,000	584,640,000		-113,229,000															14,093,000	17,459,000	12,544,000	129,663,000	-35,418,000	-14,971,000	119,409,000	53,213,000	6,008,000	8,071,952	8,801,548	31,210,500	-543,837	2,151,143	-15,453,903	49,209,621	4,912,842	8,761,563	28,570,015	10,819,844	2,509,971	3,087,107	12,792,899	3,033,525	7,466,587	4,409,035	-5,368,781	6,830,302	8,332,988	7,207,140	-1,766,630	3,414,926	3,670,604	-9,946,433	-12,134,918	-6,335,606	33,458,367	16,641,883	-22,495,476	31,638,767	6,776,964	2,438,257	-191,048	138,549	5,340,747		-1,467,340	1,066,794	4,846,937		-628,860	-150,242	4,102,956
supplemental disclosure of non-cash investing and financing activities:
assets acquired under operating leases	0	4,008,000	36,000	13,807,000	227,000	767,000	23,093,000	3,206,000	298,000	652,000	179,000	3,421,000	3,966,000	20,620,000	1,119,000	52,794,000	3,913,000	25,423,000	3,182,000	1,893,000	1,439,000	0	17,000
fair value of shares of common stock issued for contingent consideration earnouts	0			0	0	5,201,000	541,000
cash flows from operating activities:
unrealized loss on derivative contracts		486,000	8,223,000
loss on disposal of fixed assets		2,164,000	1,218,000
other		-681,000	1,034,000	-337,000	279,000	-67,000	-105,000	370,000	287,000	1,431,000	-857,000	-310,000	-66,000	203,000	73,000	174,000	574,000	97,000	6,000	39,000	85,000	3,000	140,000	549,000	111,000
cash flows from investing activities:
cash flows from financing activities:
other financing activities						-166,000	-137,000
cash, cash equivalents, beginning of period		0	757,355,000		0
inventory step-up charges																		0	1,598,000
contingent consideration								697,000	-34,292,000	1,791,000	1,235,000		-2,309,000	-6,884,000	-2,411,000
non-cash interest income								0
loss on extinguishment of debt																								0
loss on fixed asset abandonment
prepaid expenses and other assets						2,572,000	-4,571,000	-2,297,000	797,000	-8,731,000	-2,799,000	2,228,000	-2,234,000	2,130,000	272,000	-10,663,000	1,034,000	1,851,000	-2,414,000	-1,962,000	-1,275,000	-1,669,000	36,000	414,000	-1,189,000	-101,000	215,000
other assets						44,000	320,000	246,000	181,000	-454,000	-434,000	67,000	108,000	-1,716,000	1,310,000	-319,000	-997,000	995,000	753,000	-21,000	-184,000				-1,000				-107,000				50,000
accrued expenses						1,985,000	6,381,000	373,000	-2,060,000	-12,908,000	-13,326,000	-5,062,000	7,057,000	5,985,000	-9,999,000	13,145,000	5,584,000	9,373,000	-4,906,000	3,749,000	4,300,000	-2,023,000	-4,989,000	5,833,000	5,621,000	3,497,000	-1,855,000																																																						192,344	231,473	-238,283	391,669
operating lease liability																			1,649,000	-1,133,000	-527,000	-638,000	334,000	6,054,000	609,000	-376,000	-840,000
long-term liabilities						47,000	-148,000	8,000	-75,000	95,000	59,000	1,338,000	-764,000	639,000	-247,000	168,000	195,000	-1,254,000	-533,000	-358,000	570,000	717,000	180,000	-10,587,000	10,576,000	-2,000	-6,000	-581,000	44,000	46,000	-3,000	782,000	-85,000	-43,000	-43,000	-192,000	18,000	-136,000	70,000	2,355,000	185,413	2,082,986	-2,508,399	-781,495	-47,197	-101,174	-106,216	685,212	934,815	-1,129,760	-104,137	-1,219,417	141,796	70,967	3,799	-7,635	-32,838	-3,149	-3,149	-19,149	27,496	-9,149	-9,149	-9,149	-4,560	-43,407	-6,370	-6,308	5,943	-41,663	-16,314	-5,265	888	76,096	964	-108,124	310	354	358	482
purchase of marketable securities held to maturity
redemption of marketable securities
purchase of intellectual property												0
repurchase of common stock																																																																	-1	-1,665,353
proceeds from issuance of 2023 convertible senior notes
payment of debt issuance costs
payment of tax withholding obligation on vesting of restricted stock units
supplemental disclosure of cash flow information:
income taxes paid																							1,756,000	2,299,000	1,501,000	1,650,000	1,055,000			521,000	937,000	466,000	1,405,000	969,000	1,181,000	1,105,000	907,000	942,000	1,039,000	2,277,000	1,042,000	529,000	1,100,000	1,876,000	3,000	202,000	466,000
interest paid																							527,000	0								1,222,000
fair value of shares of common stock issued for acquisitions
acquisition date fair value of contingent consideration earnouts
acquisition of intangible assets and issuance of financing liability
issuance of 2023 notes in exchange of 2019 notes
extinguished 2019 notes
operating lease right of use asset amortization*
proceeds from maturity of marketable securities held to maturity									0
fair value of 31,415 shares of common stock issued for the acquisition of flexbiosys, inc.									222,000
operating lease right of use assets						3,116,000	-19,465,000	3,856,000	3,716,000	3,138,000	3,349,000	-2,516,000	-576,000						-1,864,000	1,009,000	730,000	925,000	919,000	-5,449,000	-419,000	422,000	784,000
cash, cash equivalents and restricted cash, beginning of period							751,323,000		0	0	523,458,000	0	0	0	603,814,000	0	0	0	717,292,000	0	0	0	537,407,000	0	0	0	193,822,000	0	0	0	173,759,000
amortization of debt issuance costs									459,000	457,000	457,000
proceeds from issuance of common stock									-10,000																131,090,000
fair value of 42,621 shares of common stock issued for the avitide, inc. contingent consideration earnout									0
noncash interest income
effect of exchange rate changes on cash, cash equivalents and restricted cash											993,000	9,795,000	-8,273,000	-5,336,000	-2,052,000	-4,859,000	-2,895,000	2,214,000	-6,746,000	8,569,000	3,353,000	5,730,000	-4,923,000	4,595,000	-5,336,000	1,242,000	-3,691,000
net decrease in cash, cash equivalents and restricted cash											-6,849,000				-19,174,000
stock-based compensation expense												6,262,000	6,154,000	6,985,000	7,915,000	7,024,000	6,792,000	7,143,000	6,541,000	4,515,000	4,225,000	4,102,000	4,165,000	3,388,000	3,176,000	3,032,000	3,251,000	2,520,000	2,779,000	2,625,000	2,268,000	1,902,000	1,818,000	1,496,000	1,531,000	1,254,000	1,282,000	1,137,000	922,000	930,000	981,074	984,944	701,982	380,804	533,091	545,212	307,425	205,772	312,691	250,071	280,205	288,278	214,796	240,873	244,597	282,017	255,031	243,223	242,130	262,882	234,482	300,603	234,758	236,955	244,663	219,746	198,404	160,432	134,287	131,944	71,582	186,574	195,878	136,644	255,476	248,534								67,826
contingent consideration expense
proceeds from issuance of common stock, net of issuance costs																																0
net increase in cash, cash equivalents and restricted cash																-17,284,000	-113,229,000	23,009,000	-5,974,000	163,990,000	-7,062,000	21,798,000	1,159,000	14,978,000	304,612,000	21,682,000	2,313,000	3,518,000
fair value of 271,096 shares of common stock issued for acquisition of avitide, inc.																5,392,000
fair value of earnouts related to the acquisition of avitide, inc.
fair value of 372,990 shares of common stock issued for acquisition of artesyn biosolutions holdings ireland limited
fair value of 271,096 shares of common stock issued for the acquisition of avitide, inc.
fair value of earnouts related to acquisition of avitide, inc.
unbilled receivables															11,000	21,000				0				99,000	-95,000	-460,000	2,602,000
loss on conversion of debt
proceeds from issuance of senior convertible notes, net of issuance costs
exercise of stock options																							1,599,000	109,000	492,000	522,000	44,000	1,044,000	884,000	1,146,000	344,000	316,000	530,000	172,000	1,333,000	211,000	672,000	137,000	821,000	-61,000	241,339	283,656	402,005	194,100	148,425	840,197	497,709	200,729	1,077,824	956,721	272,360	751,718	21,446	113,540			-19,187	0	9,006	16,752	0	4,322	45,913	3,756	137,500	6,047	23,757	234,455	215,756	242,999	58,190	120,710	139,200	0			286,290	24,472			25,000	158	1,511	3,832
repayment of senior convertible notes																								0	-114,972,000			0	0	0	-11,000
cash, cash equivalents and restricted cash, end of period																			711,318,000	163,990,000	-7,062,000	21,798,000	538,566,000	14,978,000	304,612,000	21,682,000	196,135,000	3,518,000	14,693,000	1,735,000	173,876,000
fair value of 2,316,229 shares of common stock issued for conversion of convertible notes																								0
fair value of common stock issued for acquisition of c technologies, inc.																								0	0
royalties and other receivables																				-29,000	-27,000	36,000	148,000	-130,000	-88,000	2,000	112,000																-154,525	-120,698	323,625	-376,540	6,730,818	-1,281,620	-1,467,682	5,284,800
developed technology intangible asset payment
non-cash effect of adoption of asu 2016-16																												0	0	0	5,609,000
property, plant and equipment related to lease incentives																												0
non-cash interest expense																					2,760,000	2,724,000	2,691,000	2,673,000	2,632,000	1,124,000	1,107,000	1,088,000	1,071,000	1,053,000	1,036,000	1,019,000	1,002,000	986,000	970,000	954,000	938,000
proceeds from issuance of convertible debt
acquisition of c technologies, inc., net of cash acquired																									22,000
exercise of stock options and vesting of stock units
deferred tax expense																										-3,000	892,000	-401,000	147,000	-124,000	449,000		-7,678,000	-5,394,000	10,000	-4,418,000	108,000			-336,000	44,895	86,553	86,552	33,624	107,767	146,138	7,566	1,449,740	1,105,259	-112,403
purchases of marketable securities																																1,000	-6,000	-14,000	-28,000	-2,306,000	-17,442,000	17,000	-3,969,000	-6,078,000	-5,971,062	-4,832,048	-3,286,890	-3,271,343	-5,601,015	-9,664,478	-8,970,763	-5,909,735	-7,549,994	-10,538,701	-2,772,316	-13,360,596	-8,364,554	-14,612,493	-14,878,661	-24,268,361	-26,234,591	-24,687,654	-15,472,992	-17,934,494	-2,923,047	-14,149,356	-15,477,553	-14,488,104	-5,212,937	-26,585,625	-14,526,029	-10,540,882	-10,357,833	-25,918,364	-11,202,051	-7,319,705	-3,779,047	-3,152,632	-3,170,897	-3,871,320	-2,164,932	-2,483,630	-4,765,724	-1,969,309	-4,913,364	-1,951,921	-5,873,879	-4,482,587
acquisition of spectrum lifesciences, inc., net of cash acquired
acquisition of c technologies, inc. net of cash acquired
fair value of common stock issued for acquisition of spectrum, inc.
payment of contingent consideration in common stock																																1,000	0	0	1,062,000	0	0	0	875,000
business acquisitions:
fair value of tangible assets acquired																								0	0
fair value of accounts receivable
fair value of other assets																								0	0
deferred tax assets
liabilities assumed																								-13,000	-44,000
fair value of stock issued																								0	0
cost in excess of fair value of assets acquired																								-882,000	22,000
acquired identifiable intangible assets																								0	0
deferred tax liabilities
less working capital adjustment
net cash paid for business acquisitions																								0	-22,000
deferred taxes
fair value of accounts receivables																									0
loss on revaluation of contingent consideration																																				-75,000	675,000	637,000	2,005,000	1,969,000	233,070	768,556	1,112,374										37,503	24,629
acquisition of atoll gmbh, net of cash acquired
acquisition of tangenx technology corporation, net of cash acquired
proceeds from sale of fixed asset
payments of contingent consideration
common stock tendered for acquisition of spectrum, inc.
common stock tendered for acquisition of atoll gmbh
less accrued contingent consideration
benefit from doubtful accounts
loss on conversion of convertible senior notes																													0
loss on disposal of assets																																0	0	5,000	59,000			23,000	3,000	0	-156				0																				5,233	0
changes in assets and liabilities:
other receivables																													-209,000	-67,000	127,000		-30,000	54,000	172,000		338,000	-69,000	-249,000		466,478
net cash from operating activities																													19,680,000	5,963,000	1,572,000	15,218,000	-1,728,000	2,814,000	1,147,000	1,954,000	-1,186,000	10,564,000	-3,811,000	3,352,000	6,587,966	7,417,391	-2,304,357	1,753,430	6,327,542	2,321,536	7,998,790	6,201,075	8,795,981	3,594,703	7,229,444	2,471,341	2,005,001	1,733,822	148,090	-2,710,594	1,444,080	1,113,956	1,135,082	-461,355	-363,301	1,348,159	-1,565,586	-1,867,626	-95,018	889,464	-124,280	5,636,978	-269,866	-1,472,464			671,391	106,925	-68,324	-304,510	239,903	-1,077,332	90,931	1,161,882	216,883			41,906
capex																													-4,168,000	-2,848,000	-1,564,000	-1,768,000	-1,010,000	-1,381,000	-1,295,000	-863,000	-2,056,000	-975,000	-431,000	-573,000	-318,305	-464,899	-1,271,796	-2,638,439	-1,740,017	-627,303	-596,788	-2,669,630	-783,118	-322,099	-438,586	-311,546	-356,773	-156,742	-170,632	-168,002	-206,684	-163,233	-90,794	-63,955	-156,512	-90,908	-224,499	-125,430	0	-290,279	-130,552	-332,727	0	-237,172			-116,150	-186,503	-438,981	-584,895	-177,212	-314,544	-145,005	-98,734	-28,257			-9,272
free cash flows																													15,512,000	3,115,000	8,000	13,450,000	-2,738,000	1,433,000	-148,000	1,091,000	-3,242,000	9,589,000	-4,242,000	2,779,000	6,269,661	6,952,492	-3,576,153	-885,009	4,587,525	1,694,233	7,402,002	3,531,445	8,012,863	3,272,604	6,790,858	2,159,795	1,648,228	1,577,080	-22,542	-2,878,596	1,237,396	950,723	1,044,288	-525,310	-519,813	1,257,251	-1,790,085	-1,993,056	-95,018	599,185	-254,832	5,304,251	-269,866	-1,709,636			555,241	-79,578	-507,305	-889,405	62,691	-1,391,876	-54,074	1,063,148	188,626			32,634
acquisition of spectrum inc., net of cash received
redemptions of marketable securities																																0	2,750,000	9,450,000	7,400,000	3,700,000	5,600,000	8,500,000	5,600,000	9,323,000	7,905,265	5,520,885	4,837,850	4,686,692	5,625,169	13,962,810	10,529,183	6,510,192	7,571,448	5,811,555	6,351,154	12,380,000	10,100,000	14,383,333	18,265,570	20,410,000	29,425,417	18,725,000	21,250,000	14,250,000	12,430,000	11,160,000	20,638,452	15,108,355	-4,184,591	15,547,187	8,710,639	5,900,000	27,546,877	4,925,000	2,000,000	7,200,000	5,525,000	3,075,000	3,800,000	4,675,000	2,800,000	2,385,616	5,851,024	2,546,360	4,597,367	1,495,182	6,619,042	4,590,400
net cash from investing activities																													-4,168,000	-2,848,000	-1,564,000	-1,171,000	-111,207,000	8,055,000	6,077,000	-35,316,000	-13,898,000	-1,180,000	1,200,000	2,672,000	1,615,898	223,938	279,164	-1,223,090	-1,715,863	-17,814,908	961,632	-2,069,173	-761,664	-5,049,245	3,140,252	-1,292,142	1,378,673	-385,902	3,216,277	-4,026,363	2,984,142	-6,425,887	5,686,214	-3,748,449	7,570,441	-3,080,264	4,936,400	494,821	-9,983,969				16,697,550	-21,230,536	-9,380,954	-314,721	1,629,803	-264,135	190,122	218,785	457,856	-412,558	948,395	470,217	-344,254	-470,818	744,113	98,541
payment of contingent consideration
net cash from financing activities																													884,000	1,146,000	333,000	303,000	129,814,000	158,000	-330,000	-89,000	419,000	111,460,000	323,000	-61,000	241,339	283,656	303,005	797,777	-455,252	840,197	497,709	200,729	1,077,824	956,721	272,360	751,718	21,446	113,540			-19,187	-56,850	9,006	16,752	0	-34,525	44,112	1,999	132,554	-1,695,665	-265,384	232,860	214,199	207,524	56,707	119,263	137,063	-33,838	16,751	-2,005	284,327	22,550	27,468	-1,843	20,198	158	1,511	3,832
supplemental disclosure of cash flow activities:
cash paid during the period for:
income taxes
interest
non-cash investing and financing activities:
stock tendered for acquisition of spectrum
supplemental disclosure of non-cash activities:
loss on conversion of senior convertible notes																															1,000
net income:																																								265,000	2,537,956	3,612,557	2,929,487				4,277,103			2,338,236																						239,978	-106,969	-19,709
deferred tax benefit
gain on sale of fixed assets																																				0	0
acquisition of assets of spectrum, inc., net of cash acquired
acquisition of assets of atoll gmbh, net of cash acquired
acquisition of assets of tangenx technology corporation, net of cash acquired
decrease of restricted cash
proceeds from sale of fixed assets																																				0	0
supplemental information:
acquisition of spectrum, inc., net of cash received
acquisition of atoll gmbh, net of cash received																																					0
proceeds from issuance of convertible senior notes, net of issuance costs
payment of contingent considerations																																	-25,000	-14,000	-1,663,000		0	0	-498,000		0	0	-99,000
stock tendered for acquisition of spectrum, inc.
stock tendered for acquisition of atoll gmbh																																					0
proceeds from issuance of convertible senior notes, net of costs																																					-253,000
acquisition of assets of refine technology, llc																																												0	0
increase of restricted cash
in-process research and development
working capital adjustment, reflected in other receivables as of december 31, 2014
excess tax benefit on exercise of stock options
net cash paid for business acquisition
bad debt reserve																																									-21,902
increase in restricted cash																																													0
supplemental disclosure of non-cash investing activities:
gain on bargain purchase																																																			0	0	0	-314,244
gain on disposal of assets
gain on revaluation of contingent consideration																																													10,315	17,700	98,320
sales of marketable securities
acquisition of assets of bioflash partners, llc																																																									0
acquisition of assets and liabilities of novozymes
repurchase and retirement of treasury stock
principal payments under capital lease obligations																																																									0				0	-38,847	-1,801	-1,757		-36,359	-39	-1,595		-35,475
contingent consideration transferred in the novozymes acquisition
(gain) loss on revaluation of contingent consideration																																																	35,387	-53,974
benefit from bad debts																																																						8,036
fair value adjustments to contingent consideration
royalties receivable																																																				-383,149	-498,967	126,252	-17,001	-259,855	233,998	-233,600	-35,000	-182,000	459,100	-198,800	-175,000	-344,500	141,400
novozymes acquisition
contingent consideration transferred in acquisition of bioflash partners, llc
income taxes refunded
net decrease in cash and cash equivalents																																																								-6,736,957				-4,193,052												-949,541									-107,173
income taxes (refunded) paid
issuance of common stock for license																																																																					0	0	0	300,000
consideration transferred in acquisition of bioflash partners, llc
non-cash tender of common stock to exercise stock options																																																																					-161,858	161,858
supplemental disclosure of noncash activities:
disposal of fully depreciated equipment																																																																		0	0	3,000
adjustments to reconcile net income to net cash from operating activities
depreciation
purchases of property and equipment
principal payments under capital lease obligation																																																																								-1,447	-2,137	-33,838	-2,049	-2,005	-1,963	-1,922	-1,881	-1,843
reclassification of deferred compensation
net cash (used in) investing activities																																																																			-5,945,942	-4,973,609
issuance of common stock for services
supplemental disclosure of non-cash activities
purchase of capital lease equipment
recording of deferred compensation
accrued expenses and other current liabilities
non-cash purchase of equipment through capital lease obligations
net cash from by operating activities																																																																								-754,083
non-cash purchase of equipment through capital lease obligation
issuance of common stock for service
non-cash purchase of equipment																																																																											7,608	133,261
adjustments to reconcile net income to net cash from operating activities-
impairment of long lived asset
common stock warrants issued for services
decrease in bad debt reserve
cash, beginning of period
cash, end of period
purchases of capital lease equipment
stock based compensation expense																																																																																	-53,543	4,660
reduction in bad debt reserve
net increase in cash																																																																														-1,467,340	1,066,794	1,630,256
non cash purchases of property, plant and equipment through capital lease obligation																																																																														0
disposal of fixed assets
adjustment to reconcile net income to net cash from operating activities:
adjustments to reconcile net income to net cash from operating activities—
common stock warrants issued for payment for services
increase(decrease) in bad debt reserve
decrease in restricted cash
cash, beginning of year
cash, end of year
common stock issued for payment of license
issuance of common stock warrants for payment for services
long term liabilities																																																																																		14,681	18,759	59,539
proceeds from issuance of common stock and warrants, net of issuance cost
supplemental disclosure of non cash activities:
non cash purchases of pp&e
disposal of fixed assets no longer in service																																																																																		0	0	128,629
net cash (used in) operating activities
net (decrease) in cash and cash equivalents
non cash purchases of property, plant and equipment
proceeds from issuance of common stock and warrants, net of issuance costs
non cash purchases of property and equipment

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