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Regeneron Pharmaceuticals Quarterly Balance Sheets Chart

Quarterly
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Annual
 
 Account Receivables  
 Cash and Cash Eq  
 Account Payables  
 Deferred Revenue  
 Long-Term Debt  
 Inventory  
20200930 20201231 20210331 20210630 20210930 20211231 20220331 20220630 20220930 20221231 20230331 20230630 20230930 20231231 20240331 20240630 20240930 20241231 20250331 20250630 01234567Billion

Regeneron Pharmaceuticals Quarterly Balance Sheets Table

Quarterly
 | 
Annual
 
Unit: USD2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-09-30 2007-06-30 2007-03-31 2006-12-31 2006-09-30 2006-06-30 2006-03-31 2005-12-31 2005-09-30 2005-06-30 2005-03-31 2004-12-31 2004-09-30 2004-06-30 2004-03-31 2003-12-31 2003-09-30 2003-06-30 
                                                                                        
  assets                                                                                      
  current assets:                                                                                      
  cash and cash equivalents1,995,800,000 3,090,200,000 2,488,200,000 2,011,800,000 1,920,700,000 2,602,000,000 2,730,000,000 2,152,300,000 1,937,200,000 3,916,300,000 3,105,900,000 3,491,300,000 3,395,100,000 3,345,700,000 2,885,600,000 3,432,400,000 2,072,200,000 1,437,900,000 2,193,700,000 1,573,000,000 1,992,200,000 2,208,200,000 1,617,800,000 1,384,800,000 1,045,500,000 1,708,500,000 1,467,700,000 1,087,843,000 917,876,000 1,019,491,000 812,733,000 792,065,000 744,313,000 811,773,000 535,203,000 920,359,000 646,508,000 604,214,000 809,102,000 654,587,000 390,554,000 507,907,000 648,719,000 646,554,000 600,135,000 461,858,000 535,608,000 263,211,000 381,675,000 180,362,000 230,276,000 118,998,000 171,943,000 394,585,000 206,395,000 254,312,000 135,376,000 112,572,000 325,286,000 112,000,000 117,311,000 207,075,000 250,321,000 271,466,000 247,796,000 314,684,000 292,129,000 520,875,000 97,416,000 109,643,000 156,484,000 237,876,000 167,662,000 114,960,000 182,332,000 184,508,000 176,093,000 145,201,000 147,816,000 101,234,000 105,047,000 122,833,000 174,034,000 118,285,000 298,617,000 129,659,000 
  marketable securities5,473,800,000 5,259,200,000 6,524,300,000 7,784,700,000 7,888,300,000 7,917,500,000 8,114,800,000 7,761,300,000 6,990,500,000 5,043,400,000 4,636,400,000 3,530,400,000 4,171,300,000 3,704,900,000 2,809,100,000 2,355,200,000 1,838,600,000 2,065,900,000 1,393,300,000 1,452,900,000 1,152,000,000 1,795,200,000 1,596,500,000 1,493,100,000 1,624,200,000 1,523,900,000 1,342,200,000 1,104,309,000 765,642,000 605,461,000 596,847,000 586,879,000 523,537,000 495,311,000 503,481,000 488,032,000 398,656,000 244,965,000 236,121,000 241,055,000 213,694,000 234,257,000 251,761,000 395,650,000 216,774,000 186,275,000 158,376,000 182,112,000 155,831,000 127,348,000 77,819,000 143,554,000 129,079,000 37,713,000 39,103,000 55,371,000 91,065,000 136,796,000 153,767,000 194,337,000 186,328,000 134,255,000 129,475,000 120,452,000 226,954,000 348,924,000 408,275,000 222,373,000 299,566,000 351,054,000 295,910,000 221,400,000 94,227,000 158,616,000 120,061,000 114,037,000 131,449,000 190,612,000 206,090,000 52,930,000 168,120,000 215,699,000 135,725,000 72,792,000 6,450,000 4,185,000 
  accounts receivable5,610,000,000 5,561,000,000 6,211,900,000 6,107,100,000 5,717,100,000 5,222,200,000 5,667,300,000 5,584,500,000 5,121,300,000 5,118,600,000 5,328,700,000 5,548,300,000 5,161,400,000 4,839,000,000 6,036,500,000 5,452,000,000 6,998,600,000 4,173,000,000                                                   10,968,000 20,478,000 33,632,000 7,493,000 7,940,000 12,141,000 11,010,000 36,521,000 10,536,000 16,830,000 10,371,000 43,102,000 24,866,000 25,397,000 59,882,000 15,529,000 9,197,000 7,871,000 
  inventories3,205,600,000 3,192,400,000 3,087,300,000 3,018,000,000 2,873,600,000 2,714,900,000 2,580,500,000 2,562,000,000 2,507,700,000 2,424,700,000 2,401,900,000 2,412,200,000 2,218,500,000 1,991,500,000 1,951,300,000 2,053,800,000 1,983,900,000 2,164,700,000 1,916,600,000 1,801,600,000 1,640,900,000 1,480,900,000 1,415,500,000 1,344,300,000 1,317,200,000 1,208,800,000 1,151,200,000 1,039,679,000 928,553,000 820,397,000 726,138,000 641,588,000 554,320,000 466,576,000 399,356,000 345,620,000 316,073,000 303,294,000 238,578,000 190,668,000 171,266,000 133,863,000 128,861,000 120,317,000 109,897,000 86,545,000 70,354,000                                        
  prepaid expenses and other current assets574,300,000 468,900,000 349,200,000 412,000,000 681,900,000 414,900,000 386,600,000 574,700,000 366,300,000 406,200,000 411,200,000 446,400,000 583,600,000 424,900,000 332,400,000 482,000,000 444,300,000 213,600,000 160,800,000 230,600,000 263,800,000 226,600,000 387,100,000 226,900,000 208,200,000 182,200,000 243,300,000 284,807,000 163,599,000 155,451,000 224,972,000 143,761,000 193,334,000 146,055,000 130,528,000 103,806,000 96,017,000 115,685,000 163,501,000 89,494,000 43,099,000 34,099,000 71,486,000 61,732,000 60,674,000 52,252,000 96,141,000 156,839,000 108,913,000 97,142,000 56,663,000 84,780,000 32,791,000 26,270,000 15,927,000 19,026,000 10,904,000 15,142,000 14,379,000 16,217,000 19,947,000 18,610,000 14,032,000 13,068,000 11,480,000 9,726,000 9,151,000 11,297,000 14,070,000 15,806,000 3,137,000 3,215,000 3,920,000 3,211,000 2,990,000 3,422,000 4,043,000 2,923,000 2,490,000 1,642,000 3,391,000 3,033,000 2,568,000 1,898,000 2,810,000 3,063,000 
  total current assets16,859,500,000 17,571,700,000 18,660,900,000 19,333,600,000 19,081,600,000 18,871,500,000 19,479,200,000 18,634,800,000 16,923,000,000 16,909,200,000 15,884,100,000 15,428,600,000 15,529,900,000 14,306,000,000 14,014,900,000 13,775,400,000 13,337,600,000 10,055,100,000 9,779,100,000 9,097,600,000 7,860,200,000 8,644,100,000 7,689,100,000 7,109,100,000 6,651,000,000 6,928,600,000 6,447,600,000 5,719,583,000 4,814,917,000 4,544,732,000 4,335,030,000 4,135,742,000 3,860,051,000 3,669,263,000 3,180,188,000 3,501,689,000 3,209,225,000 3,133,379,000 2,915,095,000 2,675,640,000 2,283,341,000 2,310,714,000 2,167,461,000 2,200,512,000 1,918,695,000 1,871,049,000 1,796,934,000 1,634,160,000 1,561,362,000 1,307,122,000 1,206,012,000 948,603,000 769,193,000 696,915,000 339,872,000 413,273,000 325,501,000 357,622,000 575,719,000 417,750,000 395,444,000 425,508,000 461,594,000 465,032,000 521,442,000 715,540,000 742,393,000 787,505,000 422,020,000 496,981,000 489,163,000 469,984,000 273,749,000 291,056,000 319,647,000 341,392,000 324,958,000 359,312,000 369,854,000  311,238,000 383,330,000 392,284,000    
  property, plant, and equipment4,840,700,000 4,694,200,000 4,599,700,000 4,439,200,000 4,305,900,000 4,225,500,000 4,146,400,000 4,006,100,000 3,922,600,000 3,880,900,000 3,763,000,000 3,704,200,000 3,637,700,000 3,556,400,000 3,482,200,000 3,395,700,000 3,358,500,000 3,262,600,000 3,221,600,000 3,138,300,000 3,031,400,000 2,944,600,000 2,890,400,000 2,771,400,000 2,676,600,000 2,612,800,000 2,575,800,000 2,524,446,000 2,461,614,000 2,394,727,000 2,358,605,000 2,274,529,000 2,261,702,000 2,277,029,000 2,083,421,000 1,872,167,000 1,772,923,000 1,666,391,000                                                 
  intangible assets1,351,700,000 1,167,000,000 1,148,600,000 1,120,100,000 1,102,200,000 1,058,700,000 1,038,600,000 1,017,200,000 953,000,000 928,700,000 915,500,000 804,100,000                                                                           
  deferred tax assets3,572,200,000 3,442,900,000 3,314,100,000 3,015,100,000 2,880,900,000 2,764,900,000 2,575,400,000 2,316,800,000 2,138,500,000 1,924,900,000 1,723,700,000 1,452,100,000 1,352,400,000 1,140,300,000 876,900,000 723,200,000 746,600,000 765,100,000 858,900,000 804,200,000 774,000,000 771,200,000 824,200,000 808,300,000 821,600,000 829,300,000 828,700,000 562,818,000 545,077,000 532,268,000 506,291,000 927,023,000 882,980,000 866,291,000 825,303,000 655,552,000 626,191,000 543,689,000 461,945,000 60,521,000 69,603,000 62,126,000 49,235,000 49,005,000 37,291,000 36,623,000 44,677,000 39,174,000 38,927,000 99,632,000 148,134,000                                    
  other noncurrent assets1,536,900,000 1,393,100,000 1,136,000,000 1,043,000,000 993,800,000 470,200,000 444,100,000 409,900,000 393,200,000 349,600,000 336,400,000 320,200,000 269,900,000 262,000,000 222,800,000 145,900,000 142,900,000 145,700,000 168,100,000 168,800,000 175,500,000 161,200,000 144,700,000 137,900,000 139,800,000 144,300,000 127,400,000 125,197,000 85,669,000 78,984,000                                                         
  total assets38,219,200,000 37,545,200,000 37,759,400,000 37,441,900,000 36,086,800,000 34,369,600,000 33,080,200,000 32,163,300,000 30,657,500,000 30,059,900,000 29,214,500,000 27,677,800,000 27,205,800,000 26,348,700,000 25,434,800,000 23,671,500,000 21,485,900,000 17,772,200,000 17,163,300,000 16,084,000,000 14,428,700,000 15,757,500,000 14,805,200,000 13,939,300,000 13,173,600,000 12,854,800,000 11,734,500,000 10,805,613,000 9,951,980,000 9,372,696,000 8,764,286,000 8,701,215,000 8,106,373,000 7,817,365,000 6,973,466,000 6,828,019,000 6,204,906,000 5,904,460,000 5,609,132,000 5,182,915,000 4,526,970,000 4,198,573,000 3,871,827,000 3,739,419,000 3,456,078,000 3,260,396,000 2,951,013,000 2,640,415,000 2,378,259,000 2,275,998,000 2,080,490,000 1,660,615,000 1,457,500,000 1,350,159,000 983,031,000 1,046,864,000 1,074,293,000 1,089,432,000 942,433,000 790,641,000 787,156,000 741,202,000 742,192,000 742,345,000 670,038,000 825,891,000 851,225,000 930,876,000 573,096,000 597,858,000 601,431,000 585,090,000 355,186,000 378,332,000 402,089,000 423,501,000 419,275,000 446,948,000 470,292,000  472,685,000 488,174,000 506,178,000    
  liabilities and stockholders' equity                                                                                      
  current liabilities:                                                                                      
  accounts payable723,900,000 705,500,000 789,500,000 497,300,000 561,700,000 671,300,000 606,600,000 536,600,000 547,300,000 599,500,000 589,200,000 535,600,000 534,200,000 470,300,000 564,000,000 427,000,000 476,000,000 542,900,000 475,500,000 443,100,000 380,100,000 347,800,000 418,100,000 335,600,000 244,000,000 239,600,000 218,200,000 172,361,000 171,906,000 207,611,000                                                         
  accrued expenses and other current liabilities2,461,200,000 2,241,800,000 2,527,100,000 2,536,500,000 2,360,900,000 2,392,900,000 2,357,900,000 2,644,700,000 2,176,000,000 2,074,300,000 2,074,200,000 1,796,400,000 1,933,400,000 2,046,000,000 2,206,800,000 2,061,000,000 2,018,000,000 1,492,200,000 1,521,800,000 1,303,000,000 1,257,000,000 1,143,200,000 1,086,800,000 821,100,000 876,700,000 741,100,000 772,100,000 781,924,000 670,709,000 666,216,000                                                         
  deferred revenue481,900,000 619,300,000 627,700,000 627,200,000 586,000,000 516,700,000 458,900,000 417,300,000 381,100,000 426,300,000 477,900,000 547,200,000 566,300,000 491,300,000 442,000,000 507,800,000 520,000,000 464,900,000                                                   125,013,000 113,691,000 121,138,000 123,452,000 60,015,000 63,057,000 66,099,000 69,142,000 49,373,000 51,939,000 54,577,000 56,426,000 57,876,000 60,598,000 65,621,000 68,830,000 89,563,000 3,493,000 
  total current liabilities3,667,000,000 3,566,600,000 3,944,300,000 3,661,000,000 3,508,600,000 3,580,900,000 3,423,400,000 3,598,600,000 3,104,400,000 3,100,100,000 3,141,300,000 2,879,200,000 3,033,900,000 3,007,600,000 3,932,500,000 3,714,800,000 3,732,400,000 3,217,800,000 2,697,400,000 2,337,800,000 3,702,400,000 2,055,200,000 2,096,600,000 1,765,400,000 1,713,100,000 1,511,400,000 1,442,800,000 1,417,230,000 1,331,190,000 1,265,740,000 1,135,483,000 1,138,628,000 1,029,017,000 1,308,271,000 1,241,495,000 961,185,000 951,563,000 919,724,000 811,162,000 734,990,000 601,542,000 536,134,000 654,660,000 410,200,000 351,578,000 305,068,000 298,835,000 268,727,000 203,802,000 197,244,000 163,550,000 178,568,000 183,220,000 160,386,000 133,235,000 135,868,000 112,252,000 109,056,000 133,833,000 119,571,000 104,093,000 93,575,000 114,165,000 120,424,000 83,672,000 217,771,000 223,918,000 285,954,000 96,686,000 104,831,000 83,604,000 45,014,000 32,698,000 31,508,000 33,667,000 40,357,000 33,521,000 29,949,000 29,931,000  35,900,000 37,372,000 36,335,000    
  long-term debt1,985,100,000 1,984,800,000 1,984,400,000 1,984,000,000 1,983,600,000 1,983,300,000 1,982,900,000 1,982,600,000 1,982,200,000 1,981,800,000 1,981,400,000 1,981,100,000 1,980,700,000 1,980,400,000 1,980,000,000 1,979,600,000 1,979,200,000 1,978,900,000 1,978,500,000 1,978,300,000                                                                   
  finance lease liabilities720,000,000 720,000,000 720,000,000 720,000,000 720,000,000 720,000,000 720,000,000 720,000,000 720,000,000 720,000,000     719,700,000 719,000,000 718,400,000 717,800,000 717,200,000 716,500,000 715,900,000 715,200,000 713,900,000 712,700,000 711,300,000 709,900,000                                                             
  other noncurrent liabilities1,701,900,000 1,674,400,000 1,571,400,000 1,543,600,000 1,463,200,000 908,500,000 854,100,000 832,400,000 716,800,000 677,300,000 638,000,000 598,600,000 724,700,000 692,500,000 680,200,000 662,600,000 596,300,000 571,500,000 497,800,000 454,000,000 457,900,000 321,500,000 286,000,000 273,000,000 267,900,000 376,300,000 361,700,000 194,033,000 190,020,000 169,922,000                                                         
  total liabilities8,280,300,000 8,157,600,000 8,405,800,000 8,116,000,000 7,881,000,000 7,378,500,000 7,107,100,000 7,258,900,000 6,639,600,000 6,564,700,000 6,550,500,000 6,239,000,000 6,518,000,000 6,434,000,000 6,666,000,000 6,413,500,000 6,358,600,000 5,795,200,000 6,138,000,000 5,958,500,000 5,371,300,000 3,624,500,000 3,715,500,000 3,434,900,000 3,417,700,000 3,410,100,000 2,977,200,000 2,937,313,000 2,765,554,000 2,805,052,000 2,620,208,000 2,649,622,000 2,585,635,000 2,951,344,000 2,524,221,000 2,336,772,000 2,128,400,000 2,139,378,000 1,954,295,000 1,886,048,000 1,188,512,000 1,227,143,000 1,329,502,000 1,187,631,000 1,087,236,000 1,049,148,000 998,937,000 950,244,000 884,922,000 869,650,000 835,105,000 854,591,000 862,843,000 846,135,000 554,778,000 568,830,000 556,202,000 561,617,000 594,369,000 419,425,000 400,885,000 344,440,000 319,749,000 331,839,000 251,186,000 388,958,000 400,228,000 470,273,000 421,699,000 418,522,000 404,742,000 368,466,000 292,713,000 294,565,000 299,766,000 309,499,000 282,894,000 281,888,000 284,508,000  293,812,000 298,044,000 302,072,000    
  stockholders' equity:                                                                                      
  preferred stock, par value .01 per share; 30.0 shares authorized; shares issued and outstanding - none                                                                                      
  class a stock, convertible, par value .001 per share; 40.0 shares authorized; shares issued and outstanding - 1.8 in 2025 and 2024                                                                                      
  common stock100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 110,000 110,000 110,000 110,000 109,000 109,000 108,000 108,000 107,000 107,000 107,000 106,000 106,000 105,000 103,000 102,000 100,000 100,000 99,000 97,000 97,000 97,000 95,000 95,000 94,000              77,000 77,000 77,000 64,000 64,000 63,000  55,000 55,000  54,000 54,000 54,000    53,000 53,000    
  additional paid-in capital13,490,800,000 13,192,100,000 12,855,900,000 12,702,800,000 12,316,900,000 11,942,600,000 11,354,000,000 11,251,500,000 10,888,500,000 10,597,700,000 9,949,300,000 9,518,200,000 9,120,200,000 8,754,100,000 8,087,500,000 7,919,300,000 7,225,800,000 6,887,800,000 6,716,200,000 6,592,800,000 6,263,000,000 5,211,400,000 4,428,600,000 4,388,400,000 4,263,600,000 4,160,900,000 3,911,600,000 3,841,174,000 3,712,599,000 3,611,599,000 3,512,833,000 3,570,673,000 3,449,622,000 3,190,882,000 3,029,993,000 3,314,982,000 3,156,942,000 3,049,651,000 3,099,526,000 2,880,109,000 3,118,969,000 2,812,573,000 2,404,118,000 2,423,434,000 2,342,839,000 2,236,931,000 2,045,857,000 1,882,421,000 1,827,471,000 1,826,075,000 1,763,508,000 1,795,293,000 1,775,861,000 1,760,938,000 1,643,772,000 1,630,362,000 1,609,185,000 1,575,780,000 1,379,123,000 1,368,531,000 1,357,089,000 1,336,732,000 1,323,432,000 1,313,003,000 1,294,813,000 1,285,223,000 1,274,527,000 1,264,531,000 931,482,000 924,094,000 914,317,000 904,407,000 719,157,000 713,419,000 708,297,000 700,011,000 693,426,000 687,965,000 682,578,000 675,389,000 673,635,000 674,505,000 674,242,000 673,118,000 670,120,000 622,931,000 
  retained earnings33,680,200,000 32,384,400,000 31,672,900,000 30,755,200,000 29,414,600,000 27,982,300,000 27,260,300,000 26,100,700,000 25,092,900,000 24,124,500,000 23,306,700,000 22,109,600,000 20,793,900,000 19,941,800,000 18,968,300,000 16,739,300,000 15,107,100,000 12,008,200,000 10,893,000,000 9,743,800,000 8,901,700,000 8,004,400,000 7,379,800,000 6,587,800,000 5,918,200,000 5,725,100,000 5,254,300,000 4,433,904,000 3,839,179,000 3,287,767,000 2,946,733,000 2,773,214,000 2,384,897,000 1,997,153,000 1,748,222,000 1,495,107,000 1,230,303,000 1,018,436,000 852,700,000 697,706,000 487,308,000 292,665,000 255,382,000 145,206,000 65,486,000                                          
  accumulated other comprehensive income52,500,000 29,100,000  60,200,000           -26,200,000 9,500,000 15,700,000 16,200,000 29,300,000 30,800,000 35,500,000 -9,100,000 21,100,000 16,500,000 15,800,000 2,800,000 -12,300,000 -10,519,000 -11,612,000 -15,594,000 640,000 23,835,000 2,348,000  -12,840,000 -2,899,000 5,204,000 4,364,000 8,572,000 7,721,000 19,153,000 47,904,000 52,251,000 26,895,000 4,263,000 1,465,000            -2,491,000 -175,000 -306,000 717,000 1,044,000 3,537,000 1,014,000 -114,000 -3,960,000 -315,000 828,000            -769,000 -202,000 -211,000 173,000 104,000 56,000 224,000 
  treasury stock-17,284,700,000 -16,218,100,000 -15,167,400,000 -14,192,400,000 -13,455,900,000 -12,856,700,000 -12,560,400,000 -12,271,100,000 -11,765,900,000 -11,045,500,000 -10,353,300,000 -9,914,000,000 -9,002,600,000 -8,611,200,000 -8,260,900,000 -7,410,200,000 -7,221,400,000 -6,935,300,000 -6,613,300,000 -6,242,000,000 -6,142,900,000 -1,073,800,000 -739,900,000 -488,400,000 -441,800,000 -444,200,000 -396,400,000 -396,371,000 -353,852,000 -316,240,000 -316,240,000 -316,240,000 -316,240,000 -316,240,000 -316,240,000 -316,052,000 -316,052,000 -307,478,000 -306,069,000 -288,777,000 -287,079,000 -181,817,000 -169,530,000 -43,849,000 -43,848,000                                          
  total stockholders' equity29,938,900,000 29,387,600,000 29,353,600,000 29,325,900,000 28,205,800,000 26,991,100,000 25,973,100,000 24,904,400,000 24,017,900,000 23,495,200,000 22,664,000,000 21,438,800,000 20,687,800,000 19,914,700,000 18,768,800,000 17,258,000,000 15,127,300,000 11,977,000,000 11,025,300,000 10,125,500,000 9,057,400,000 12,133,000,000 11,089,700,000 10,504,400,000 9,755,900,000 9,444,700,000 8,757,300,000 7,868,300,000 7,186,426,000 6,567,644,000 6,144,078,000 6,051,593,000 5,520,738,000 4,866,021,000 4,449,245,000 4,491,247,000 4,076,506,000 3,765,082,000 3,654,837,000 3,296,867,000 3,338,458,000 2,971,430,000 2,542,325,000 2,551,788,000 2,368,842,000 2,211,248,000 1,952,076,000 1,690,171,000 1,493,337,000 1,406,348,000 1,245,385,000 806,024,000 594,657,000 504,024,000 428,253,000 478,034,000 518,091,000  348,064,000 371,216,000 386,271,000  422,443,000 410,506,000                       
  total liabilities and stockholders' equity38,219,200,000 37,545,200,000 37,759,400,000 37,441,900,000 36,086,800,000 34,369,600,000 33,080,200,000 32,163,300,000 30,657,500,000 30,059,900,000 29,214,500,000 27,677,800,000 27,205,800,000 26,348,700,000 25,434,800,000 23,671,500,000 21,485,900,000 17,772,200,000 17,163,300,000 16,084,000,000 14,428,700,000 15,757,500,000 14,805,200,000 13,939,300,000 13,173,600,000 12,854,800,000 11,734,500,000 10,805,613,000 9,951,980,000 9,372,696,000 8,764,286,000 8,701,215,000 8,106,373,000 7,817,365,000 6,973,466,000 6,828,019,000 6,204,906,000 5,904,460,000 5,609,132,000 5,182,915,000 4,526,970,000 4,198,573,000 3,871,827,000 3,739,419,000 3,456,078,000 3,260,396,000 2,951,013,000 2,640,415,000 2,378,259,000 2,275,998,000 2,080,490,000 1,660,615,000 1,457,500,000 1,350,159,000 983,031,000 1,046,864,000 1,074,293,000  942,433,000 790,641,000 787,156,000  742,192,000 742,345,000                       
  the accompanying notes are an integral part of the financial statements.                                                                                      
  commitments and contingencies                                                                                      
  class a stock, convertible, par value .001 per share; 40.0 shares authorized; shares issued and outstanding - 1.8 in 2024 and 2023                                                                                      
  accumulated other comprehensive loss  -7,900,000  -69,900,000 -77,200,000 -80,900,000 -176,800,000 -197,700,000 -181,600,000 -238,800,000 -275,100,000 -223,800,000 -170,100,000                    -5,884,000             -1,188,000 -2,851,000 -3,429,000 -1,644,000 -1,166,000 -1,904,000 -2,371,000 -1,337,000 -1,731,000 -904,000 -2,175,000            -5,000 -516,000 -159,000 -231,000 -95,000 -473,000 -371,000 -470,000 -682,000 -709,000 -1,110,000        
  class a stock, convertible, par value .001 per share; 40.0 shares authorized; shares issued and outstanding - 1.8 in 2023 and 2022                                                                                      
  preferred stock, par value .01 per share; 30.0 shares authorized; issued and outstanding - none                                                                                      
  class a stock, convertible, par value .001 per share; 40.0 shares authorized; shares issued and outstanding - 1.8 in 2022 and 2021                                                                                      
  preferred stock, .01 par value; 30,000,000 shares authorized; issued and outstanding - none                                                                                      
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 1,823,823 in 2022 and 2021                                                                                      
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 1,823,283 in 2021 and 1,848,970 in 2020                                                                                      
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 1,848,970 in 2021 and 2020                                                                                      
  accounts receivable - trade                  3,111,500,000 3,092,500,000 1,991,000,000 2,063,100,000 2,100,000,000 2,027,700,000 1,920,200,000 1,728,400,000 1,723,700,000 1,665,737,000 1,534,324,000 1,531,936,000 1,538,642,000 1,532,693,000 1,420,403,000 1,339,794,000 1,343,368,000 1,332,071,000 1,431,966,000 1,450,572,000 1,152,489,000 1,088,207,000 1,071,665,000 1,015,962,000 739,379,000 673,915,000 664,075,000 801,773,000 787,071,000 855,844,000 767,865,000 703,857,000 593,207,000 506,682,000 349,645,000 159,462,000                                 
  accounts receivable - sanofi                  404,700,000 460,800,000 389,200,000 468,300,000                                                                 
  accounts receivable - other                  598,500,000 486,200,000 431,100,000 401,800,000                                 3,659,000 2,921,000 3,765,000 13,509,000 3,048,000 4,070,000 3,020,000 2,865,000 3,813,000 5,806,000 1,910,000                      
  deferred revenue - sanofi                  341,700,000 409,300,000 380,200,000 398,000,000                                                                 
  deferred revenue - other                  236,000,000 85,500,000 81,300,000 81,200,000 196,200,000 181,600,000 168,100,000 196,600,000 205,800,000 216,133,000 180,396,000 160,466,000 249,263,000 274,666,000 295,621,000 316,227,000 327,298,000 327,868,000 146,449,000 170,658,000 82,015,000 78,942,000 76,748,000 114,318,000 103,909,000 114,339,000 128,042,000 128,539,000 107,677,000 111,893,000 119,672,000 125,436,000 131,822,000 141,132,000 149,031,000 154,929,000 166,623,000 174,987,000 183,019,000 188,775,000 197,139,000 42,009,000 44,504,000 46,951,000 49,421,000 51,893,000 56,835,000                      
  other liabilities - sanofi                  122,400,000 96,900,000 103,800,000 85,000,000                                                                 
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 1,848,970 in 2020 and 2019                                                                                      
  debt                    1,500,000,000                                                                  
  accounts receivable from sanofi                      260,600,000 345,400,000 252,000,000 287,600,000 226,400,000 269,271,000 243,238,000 168,855,000 193,684,000 217,478,000 221,078,000 214,269,000 92,989,000 124,107,000 138,067,000 173,782,000 153,152,000 199,117,000 197,693,000 159,444,000 121,058,000 110,720,000 116,865,000 118,003,000 104,707,000 136,980,000 108,151,000 98,781,000 99,913,000 94,589,000 85,735,000 78,885,000 74,788,000 81,643,000                               
  accounts receivable from bayer                      311,600,000 286,900,000 283,700,000 289,200,000 293,100,000 267,937,000 261,685,000 243,141,000 242,014,000 221,278,000 203,066,000 195,485,000 175,263,000 187,694,000 181,938,000 240,867,000                                                 
  deferred revenue from sanofi                      395,500,000 427,100,000 424,300,000 334,100,000 246,700,000 246,812,000 308,179,000 231,447,000 379,936,000 408,786,000 443,904,000 520,191,000 503,474,000 529,791,000 549,342,000 565,773,000 582,664,000 599,339,000 46,095,000 48,656,000 72,367,000 75,283,000 75,862,000 73,694,000 76,522,000 77,670,000 78,740,000 76,909,000 76,520,000 77,446,000 78,281,000 83,625,000 88,033,000 91,712,000                               
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 1,848,970 in 2019 and 1,911,354 in 2018                                                                                      
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 1,911,354 in 2019 and 2018                                                                                      
  capital and facility lease obligations                          708,500,000 707,203,000 705,903,000 704,645,000    7,200,000                                                     
  preferred stock, .01 par value; 30,0000,000 shares authorized; issued and outstanding - none                                                                                      
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 1,911,354 in 2018 and 2017                           2,000 2,000 2,000                                                         
  other assets                              77,866,000 36,618,000 36,963,000 37,087,000 20,294,000 20,705,000 6,715,000 5,791,000 5,810,000 4,583,000 4,138,000 4,473,000 3,034,000 3,416,000 8,877,000 5,340,000 5,327,000 4,409,000 15,211,000 20,078,000 23,100,000 18,322,000 19,567,000 20,393,000 13,023,000 12,287,000 10,228,000 6,789,000 6,860,000 6,697,000 7,213,000 7,338,000 6,629,000 7,460,000 8,032,000 8,273,000 512,000 342,000 1,408,000 1,645,000 1,906,000 2,170,000 2,694,000 2,915,000 3,185,000 3,465,000 4,253,000 4,472,000 4,761,000 4,984,000 5,036,000 5,235,000 5,636,000 5,833,000 5,958,000 6,223,000 
  accounts payable and accrued expenses                              815,078,000 818,426,000 716,364,000 1,061,777,000 879,096,000 714,916,000 759,643,000 733,276,000 644,112,000 577,428,000 529,505,000 462,762,000 484,228,000 337,976,000 283,385,000 237,935,000 250,896,000 219,138,000 153,826,000 145,413,000 111,345,000 124,224,000 126,768,000 106,723,000 78,890,000 81,665,000 58,602,000 53,658,000 74,976,000 58,256,000 53,905,000 49,031,000 55,291,000 51,881,000 36,168,000 41,887,000 38,289,000 30,314,000 27,872,000 34,905,000 20,081,000 21,471,000 19,054,000 16,466,000 18,383,000 23,337,000 20,599,000 17,043,000 17,468,000 18,872,000 20,284,000 15,743,000 18,947,000 18,933,000 20,967,000 14,043,000 
  deferred revenue from sanofi, current portion                              177,746,000 187,036,000 184,452,000 112,161,000 115,267,000 105,041,000 104,141,000 99,314,000 101,573,000 100,908,000 18,026,000 19,342,000 15,927,000 13,368,000 12,979,000 12,980,000 12,815,000 13,866,000 14,916,000 15,967,000 17,022,000 19,588,000 21,790,000 20,141,000 19,819,000 19,720,000                               
  deferred revenue - other, current portion                              142,392,000 132,832,000 127,804,000 126,257,000 116,397,000 137,642,000 84,084,000 73,626,000 51,914,000 54,148,000 51,720,000 51,845,000 58,098,000 57,604,000 54,154,000 53,093,000 34,185,000 34,929,000 34,266,000 34,391,000 33,809,000 33,479,000 33,479,000 32,429,000 33,606,000 33,606,000 33,291,000 35,217,000 38,888,000 41,741,000 31,969,000 27,021,000 37,294,000 46,990,000 26,114,000                      
  other current liabilities                              267,000 334,000 397,000 876,000 3,461,000 3,586,000 3,695,000 13,508,000 13,563,000 2,506,000 2,291,000 2,185,000 96,407,000                                            
  other long-term liabilities                              152,073,000 125,225,000 115,920,000 106,248,000 100,385,000 135,700,000 119,523,000 120,993,000 115,535,000 77,910,000 76,080,000 55,559,000 40,855,000 23,747,000 14,968,000 11,794,000 11,330,000 10,573,000               3,341,000                  36,000 74,000 116,000 159,000   
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 1,911,354 in 2017 and 1,911,456 in 2016                              2,000                                                        
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 1,911,456 in 2017 and 2016                               2,000 2,000 2,000                                                     
  capital lease obligations                                  127,274,000                                                    
  facility lease obligations                                  351,569,000 382,228,000 361,523,000 362,230,000 362,919,000 364,144,000 357,687,000 328,394,000 310,938,000 276,112,000 234,525,000 203,380,000 184,258,000 167,219,000 164,392,000 159,007,000 159,436,000 159,499,000 159,558,000 159,534,000 159,482,000 159,457,000 159,353,000 159,355,000 158,382,000 157,359,000 156,464,000 109,022,000                         
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 1,911,456 in 2016 and 1,913,776 in 2015                                  2,000 2,000 2,000                                                  
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 1,913,136 in 2016 and 1,913,776 in 2015                                     2,000                                                 
  accounts receivable from bayer healthcare                                      162,152,000 151,991,000 125,767,000 163,056,000 156,962,000 142,619,000 112,984,000 127,720,000                                         
  property, plant, and equipment, at cost, net of accumulated depreciation and amortization                                      1,594,120,000 1,475,123,000 1,326,112,000 1,110,597,000 974,309,000 818,967,000 707,321,000 600,864,000 526,983,000 453,891,000 419,651,000 392,378,000 379,940,000 372,917,000              72,825,000 64,231,000 58,419,000 49,358,000 47,647,000 47,781,000 49,353,000 51,035,000 53,854,000 57,421,000 60,535,000 64,044,000 67,366,000 69,055,000 71,239,000 73,942,000 75,986,000 77,616,000 80,723,000 83,715,000 84,670,000 
  convertible senior notes                                       30,723,000 30,360,000 144,082,000 146,773,000 287,950,000 282,261,000 326,673,000 320,315,000 314,162,000 308,116,000 302,268,000 296,518,000 290,959,000 285,491,000 280,206,000                                 
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 1,913,776 in 2015 and 1,973,368 in 2014                                      2,000                                                
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 1,914,776 in 2015 and 1,973,368 in 2014                                       2,000                                               
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 1,951,868 in 2015 and 1,973,368 in 2014                                        2,000                                              
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 1,971,868 in 2015 and 1,973,368 in 2014                                         2,000                                             
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 1,973,368 in 2014 and 2,020,481 in 2013                                          2,000 2,000                                           
  facility lease obligations, current portion                                           1,252,000 1,060,000 1,060,000 939,000 794,000 794,000 1,473,000 1,374,000 1,277,000 1,183,000 1,093,000 920,000 877,000 798,000 675,000 634,000 448,000 435,000                          
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 1,998,785 in 2014 and 2,020,481 in 2013                                            2,000                                          
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 2,000,781 at march 31, 2014 and 2,020,481 at december 31, 2013                                             2,000                                         
  accumulated deficit                                             -27,249,000 -92,692,000 -189,498,000 -330,804,000 -418,180,000 -517,054,000 -987,461,000 -1,178,929,000 -1,255,672,000 -1,213,880,000 -1,151,515,000 -1,089,010,000 -1,045,563,000 -1,030,966,000 -997,091,000 -971,617,000 -941,095,000 -904,606,000 -903,591,000 -875,927,000 -844,409,000 -823,294,000 -804,835,000 -780,146,000 -744,308,000 -717,534,000 -687,617,000 -656,646,000 -629,236,000 -605,660,000 -585,280,000 -555,608,000 -520,956,000 -493,957,000 -489,834,000 -492,626,000 -481,550,000 -467,001,000 -531,533,000 -512,156,000 -482,921,000 
  restricted cash and marketable securities                                                 8,494,000 8,186,000 8,173,000 8,141,000 8,154,000 8,150,000 8,165,000 7,520,000 7,518,000                             
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 2,020,481 at december 31, 2013 and 2,069,187 at december 31, 2012                                              2,000                                        
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 2,028,871 at september 30, 2013 and 2,069,187 at december 31, 2012                                               2,000                                       
  other long term liabilities                                                10,200,000 8,786,000 7,259,000 6,987,000 7,262,000 7,455,000 7,405,000 6,806,000 7,180,000 7,350,000 5,289,000 4,318,000 4,140,000 3,959,000  1,235,000 5,093,000 2,885,000                     
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 2,038,920 at june 30, 2013 and 2,069,187 at december 31, 2012                                                2,000                                      
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 2,058,057 at march 31, 2013 and 2,069,187 at december 31, 2012                                                 2,000                                     
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 2,069,187 at december 31, 2012 and 2,109,512 at december 31, 2011                                                  2,000                                    
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 2,089,512 at september 30, 2012 and 2,109,512 at december 31, 2011                                                   2,000                                   
  property, plant, and equipment, at cost, net of accumulated                                                                                      
  depreciation and amortization                                                    372,278,000 369,959,000 363,913,000 361,883,000 357,423,000 347,450,000 318,498,000 292,329,000 274,621,000 259,676,000 215,169,000 195,408,000 87,853,000                      
  class a stock, convertible, .001 par value; 40,000,000 shares authorized;                                                                                      
  shares issued and outstanding - 2,089,512 at june 30, 2012 and 2,109,512 at december 31, 2011                                                    2,000                                  
  shares issued and outstanding - 93,941,788 at june 30, 2012 and 90,692,071 at december 31, 2011                                                    94,000                                  
  shares issued and outstanding - 2,089,512 at march 31, 2012 and 2,109,512 at december 31, 2011                                                     2,000                                 
  shares issued and outstanding - 92,969,427 at march 31, 2012 and 90,692,071 at december 31, 2011                                                     93,000                                 
  current assets                                                                                      
  current liabilities                                                                                      
  stockholders' equity                                                                                      
  preferred stock, .01 par value; 30,000,000 shares authorized; issued and                                                                                      
  outstanding - none                                                                                      
  shares issued and outstanding - 2,109,512 in 2011 and 2,182,036 in 2010                                                      2,000                                
  shares issued and outstanding - 90,418,871 in 2011 and 87,238,301 in 2010                                                      90,000                                
  shares issued and outstanding - 2,126,717 in 2011 and 2,182,036 in 2010                                                       2,000                               
  shares issued and outstanding - 89,416,015 in 2011 and 87,238,301 in 2010                                                       89,000                               
  accounts receivable from the sanofi-aventis group                                                        84,391,000 79,603,000 79,239,000 91,126,000 68,838,000 62,703,000 63,953,000 54,240,000 33,302,000 37,744,000 30,438,000 31,100,000                   
  deferred revenue from sanofi-aventis, current portion                                                        19,561,000 19,506,000 19,335,000 19,126,000 17,784,000 17,523,000 21,580,000 21,553,000 21,390,000 19,017,000 18,855,000 18,855,000                   
  deferred revenue from sanofi-aventis                                                        94,398,000 97,081,000 99,726,000 96,168,000 91,684,000 90,933,000 90,251,000 95,362,000 105,586,000 112,290,000 117,004,000 121,718,000                   
  shares issued and outstanding - 2,182,036 in 2011 and 2010                                                        2,000                              
  shares issued and outstanding - 88,548,041 in 2011 and 87,238,301 in 2010                                                        89,000                              
  liabilities and stockholders’ equity                                                                                      
  stockholders’ equity                                                                                      
  preferred stock, .01 par value; 30,000,000 shares authorized; issued                                                                                      
  and outstanding - none                                                                                      
  class a stock, convertible, .001 par value: 40,000,000 shares authorized;                                                                                      
  shares issued and outstanding - 2,182,036 in 2010 and 2,244,698 in 2009                                                         2,000  2,000                           
  and outstanding - 87,238,301 in 2010 and 78,860,862 in 2009                                                         87,000                             
  total stockholders’ equity                                                         527,815,000    396,762,000   418,852,000 436,933,000 450,997,000 460,603,000 151,397,000 179,336,000 196,689,000 216,624,000 62,473,000 83,767,000 102,323,000 114,002,000 136,381,000 165,060,000 185,784,000  178,873,000 190,130,000 204,106,000    
  total liabilities and stockholders’ equity                                                         1,089,432,000    741,202,000   670,038,000 825,891,000 851,225,000 930,876,000 573,096,000 597,858,000 601,431,000 585,090,000 355,186,000 378,332,000 402,089,000 423,501,000 419,275,000 446,948,000 470,292,000  472,685,000 488,174,000 506,178,000    
  restricted cash                                                          3,400,000 3,400,000 1,600,000 1,600,000 1,600,000 1,600,000 1,650,000 1,650,000 1,650,000 1,600,000 1,600,000 1,600,000 1,600,000 1,600,000               
  shares issued and outstanding - 2,181,831 in 2010 and 2,244,698 in 2009                                                          2,000                            
  shares issued and outstanding - 80,042,523 in 2010 and 78,860,862 in 2009                                                          80,000                            
  shares issued and outstanding - 79,923,216 in 2010 and 78,860,862 in 2009                                                           80,000                           
  shares issued and outstanding - 2,211,698 in 2010 and 2,244,698 in 2009                                                            2,000                          
  shares issued and outstanding - 79,690,055 in 2010 and 78,860,862 in 2009                                                            80,000                          
  shares issued and outstanding - 2,244,698 in 2009 and 2,248,698 in 2008                                                             2,000                         
  and outstanding - 78,860,862 in 2009 and 77,642,203 in 2008                                                             79,000                         
  facility lease obligation                                                              62,571,000 62,925,000                       
  outstanding-none                                                                                      
  shares issued and outstanding - 2,246,698 in 2009 and 2,248,698 in 2008                                                              2,000 2,000                       
  shares issued and outstanding - 78,243,286 in 2009 and 77,642,203 in 2008                                                              78,000                        
  shares issued and outstanding - 77,921,038 in 2009 and 77,642,203 in 2008                                                               78,000                       
  notes payable                                                                 117,503,000 118,653,000 200,000,000 200,000,000 200,000,000 200,000,000 200,000,000 200,000,000 200,000,000 200,000,000 200,000,000 200,000,000 200,000,000 200,000,000 200,000,000 200,000,000 200,000,000 200,000,000 200,000,000 200,000,000 200,000,000 
  shares issued and outstanding - 2,248,698 in 2008 and 2,260,266 in 2007                                                                2,000                      
  and outstanding - 77,642,203 in 2008 and 76,592,218 in 2007                                                                78,000                      
  accounts receivable — other                                                                 4,462,000 2,400,000 1,860,000                   
  deferred revenue — other, current portion                                                                 39,364,000 48,121,000 36,785,000                   
  deferred revenue — other                                                                 56,012,000 59,306,000 62,601,000                   
  preferred stock, .01 par value; 30,000,000 shares authorized; issued and outstanding-none                                                                                      
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding — 2,254,698 in 2008 and 2,260,266 in 2007                                                                 2,000                     
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 2,257,698 in 2008 and 2,260,266 in 2007                                                                  2,000 2,000                   
  deferred revenue, current portion                                                                    68,814,000 69,926,000 63,523,000 23,543,000 13,644,000 15,042,000 15,284,000 17,020,000 12,922,000 12,906,000 12,463,000 15,267,000 15,616,000 21,629,000 17,388,000 40,173,000 24,473,000 35,021,000 
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 2,260,266 in 2007 and 2,270,353 in 2006                                                                    2,000                  
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 2,270,353 in 2007 and 2006                                                                     2,000 2,000                
  inventory                                                                         2,128,000 3,254,000 2,904,000 2,837,000 3,746,000 3,087,000 3,229,000 4,266,000 10,850,000 9,098,000 9,006,000 7,698,000 10,342,000 
  preferred stock, .01 par value; 30,000,000 shares authorized; issued and outstanding — none                                                                                      
  shares issued and outstanding — 2,270,353 in 2006 and 2,347,073 in 2005                                                                       2,000               
  shares issued and outstanding — 63,130,962 in 2006 and 54,092,268 in 2005                                                                       63,000               
  unearned compensation                                                                           -315,000 -811,000 -1,296,000 -1,783,000 -2,299,000 -1,989,000 -2,669,000 -3,363,000 -4,101,000 -1,873,000 -2,443,000 
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 2,296,928 in 2006 and 2,347,073 in 2005                                                                        2,000 2,000             
  shares issued and outstanding - 2,307,561 in 2006 and 2,347,073 in 2005                                                                          2,000            
  shares issued and outstanding - 54,614,557 in 2006 and 54,092,268 in 2005                                                                          55,000            
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding — 2,347,073 in 2005 and 2,358,373 in 2004                                                                           2,000           
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; shares issued and outstanding - 2,351,873 in 2005 and 2,358,373 in 2004                                                                            2,000          
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; 2,358,373 shares issued and outstanding in 2005 and 2004                                                                             2,000 2,000        
  53,763,234 shares issued and outstanding in 2005                                                                                      
  53,502,004 shares issued and outstanding in 2004                                                                              54,000        
  restricted marketable securities                                                                                5,548,000 5,518,000 10,977,000   5,319,000 
  loan payable to novartis pharma ag                                                                                      
  2,358,373 shares issued and outstanding in 2004                                                                                      
  2,365,873 shares issued and outstanding in 2003                                                                                2,000      
  53,228,223 shares issued and outstanding in 2004                                                                                      
  53,165,635 shares issued and outstanding in 2003                                                                                53,000      
  class a stock, convertible, .001 par value; 40,000,000 shares authorized; 2,365,873 shares issued and outstanding in 2004 and 2003                                                                                 2,000 2,000    
  capital lease obligations, current portion                                                                                      
  loan payable                                                                                    9,296,000 5,147,000 

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