7Baggers
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-30 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 
      
    		                                               
      operating activities:
    		                                               
      net income
    		-180,413,000 -114,951,000 -151,080,000 -133,385,000 -133,516,000 -131,598,000 -170,684,000 -123,190,000 -159,649,000 -159,828,000 -163,972,000 -151,833,000 -245,106,000 -158,162,000 -152,320,000 -122,458,000 -72,998,000 -122,428,000 -136,141,000 -24,011,000 -68,845,000 25,315,000 -119,025,000 -93,805,000 -112,994,000 -99,172,000 -96,756,000 -87,826,000 -87,310,000 -52,728,000 30,253,000 -81,731,000 -79,227,000 -72,891,000 -68,290,000 -71,287,000 -64,907,000 -56,923,000 -52,757,000 -55,220,000 -39,232,000 -29,787,000 -21,379,000 -16,738,000 -15,849,000 -13,585,000 -13,630,000 
      adjustments to reconcile net income to net cash from operating activities:
    		                                               
      stock-based compensation
    		37,265,000 38,529,000 39,917,000 40,164,000 41,569,000 39,371,000 36,926,000 33,744,000 34,877,000 34,654,000 31,952,000 29,355,000 35,762,000 35,864,000 29,396,000 26,819,000 26,788,000 27,091,000 24,254,000 22,838,000 20,339,000 22,403,000 20,155,000 19,660,000 19,907,000 22,207,000 20,221,000 21,080,000 20,667,000 19,563,000 18,797,000 19,541,000 17,180,000 16,794,000 14,499,000 13,538,000 13,694,000 10,860,000 10,217,000 9,489,000 7,896,000 5,091,000 2,408,000 2,001,000 1,652,000 946,000 795,000 
      amortization of discount on marketable debt securities
    		-704,000 -1,047,000 -1,733,000  -3,115,000 -2,947,000 -3,756,000                                         
      depreciation and amortization
    		8,606,000 8,619,000 8,990,000 9,079,000 8,757,000 8,862,000 8,845,000 8,218,000 7,191,000 5,361,000 5,236,000 4,957,000 4,694,000 4,481,000 4,088,000 3,534,000 3,217,000 3,121,000 3,367,000 3,133,000 3,092,000 3,184,000 2,852,000 2,169,000 2,145,000 2,106,000 2,119,000 2,943,000 4,355,000 6,080,000 6,160,000 2,514,000 1,095,000 1,055,000 1,161,000 1,157,000 1,031,000 692,000 544,000 480,000 441,000 262,000 201,000 212,000 194,000 161,000 117,000 
      non-cash royalty revenue
    		-24,911,000 -30,321,000 -19,187,000  -23,054,000 -26,289,000 -18,063,000  -20,543,000 -17,270,000 -4,882,000                                     
      non-cash interest expense on liabilities for sales of future royalties
    		14,148,000 14,041,000 14,342,000 15,522,000 15,712,000 15,960,000 15,847,000 17,328,000 17,665,000 15,375,000 15,636,000                                     
      other
    		-273,000 -1,172,000 -1,248,000 757,000 -3,498,000 -671,000 -77,000 -802,000 1,047,000 1,868,000 187,000 -794,000 178,000 351,000 35,000 -198,000 -78,000 186,000 325,000 1,195,000 -62,000   337,000 352,000   -11,000 0                   
      changes in operating assets and liabilities:
    		                                               
      accounts receivable
    		5,425,000 -12,653,000 10,062,000 -20,640,000 9,792,000 2,158,000 -24,908,000 1,012,000 -6,204,000 -15,078,000 -2,508,000 -9,095,000 5,929,000 -8,935,000 33,000 -3,070,000 -693,000 324,000 -1,993,000 4,714,000 -12,829,000 14,455,000 3,500,000 -9,702,000 -2,241,000 -5,262,000 -2,899,000 1,572,000                    
      inventory
    		-5,595,000 208,000 -763,000 -2,456,000 -2,500,000 -4,127,000 -2,124,000 -1,956,000 -3,467,000 -1,657,000 150,000 -4,205,000 -791,000 -3,230,000 -1,475,000 -990,000 47,000 -2,648,000 474,000 1,289,000 -3,156,000 372,000 149,000 2,153,000 -564,000 -2,393,000 -3,647,000                     
      prepaid expenses and other assets
    		9,905,000 313,000 -17,478,000      4,990,000 12,113,000 -519,000 3,240,000 7,351,000 -15,919,000 9,126,000 -22,529,000 2,023,000 1,654,000 -10,656,000 15,209,000 -6,325,000 8,960,000 -15,096,000                         
      accounts payable, accrued, and other liabilities
    		45,124,000 -9,682,000 -48,454,000 46,385,000 10,818,000 25,329,000 -35,540,000 17,126,000 7,481,000 11,781,000 -34,008,000 35,026,000 11,156,000 57,424,000 -16,164,000 30,393,000 13,446,000 12,076,000 -23,602,000 24,031,000 11,655,000 -3,450,000 -5,383,000                         
      net cash from operating activities
    		-91,423,000 -108,273,000 -166,475,000 -79,503,000 -66,995,000 -76,963,000 -190,727,000 -83,904,000 -117,874,000 -116,161,000 -156,867,000 -90,342,000 -95,345,000 -77,257,000 -117,521,000 -54,344,000 -59,649,000 -65,356,000 -159,346,000 -62,452,000 -61,967,000 87,351,000 -95,152,000 -72,039,000 -88,506,000 -89,063,000 -95,775,000 -55,853,000 -69,157,000 -76,078,000 -89,478,000 -81,823,000 -61,993,000 -48,822,000 -61,205,000 -47,680,000 -28,745,000 -39,655,000 -44,895,000 -40,444,000 -30,601,000 -17,273,000 -17,659,000 -14,739,000 -11,030,000 -10,529,000 -8,336,000 
      capex
    		-1,278,000 -2,460,000 -1,324,000 -654,000 -1,617,000 -2,009,000 -3,211,000 -1,600,000 -3,695,000 -13,938,000 -25,034,000 -26,970,000 -26,046,000 -30,923,000 -32,184,000 -16,048,000 -20,560,000 0 -16,414,000 0 -3,780,000 -4,083,000 -14,096,000 -11,500,000 -5,033,000 -5,240,000 -3,059,000 -1,192,000 -1,032,000 -1,377,000 -475,000 -899,000 -1,033,000 -376,000 -485,000 -666,000 -3,001,000 -5,044,000 -1,477,000 -1,923,000 -1,978,000 -595,000 -459,000 -453,000 -439,000 -688,000 -569,000 
      free cash flows
    		-92,701,000 -110,733,000 -167,799,000 -80,157,000 -68,612,000 -78,972,000 -193,938,000 -85,504,000 -121,569,000 -130,099,000 -181,901,000 -117,312,000 -121,391,000 -108,180,000 -149,705,000 -70,392,000 -80,209,000 -65,356,000 -175,760,000 -62,452,000 -65,747,000 83,268,000 -109,248,000 -83,539,000 -93,539,000 -94,303,000 -98,834,000 -57,045,000 -70,189,000 -77,455,000 -89,953,000 -82,722,000 -63,026,000 -49,198,000 -61,690,000 -48,346,000 -31,746,000 -44,699,000 -46,372,000 -42,367,000 -32,579,000 -17,868,000 -18,118,000 -15,192,000 -11,469,000 -11,217,000 -8,905,000 
      investing activities:
    		                                               
      purchase of property, plant, and equipment
    		-1,278,000 -2,460,000 -1,324,000 -654,000 -1,617,000 -2,009,000 -3,211,000 -1,600,000 -3,695,000 -13,938,000 -25,034,000 -26,970,000 -26,046,000 -30,923,000 -32,184,000 -16,048,000 -20,560,000                               
      purchase of marketable debt securities
    		-16,942,000   -15,933,000 -367,379,000 -3,373,000 -21,928,000 -221,593,000 -139,484,000 -103,281,000 -62,024,000 -198,574,000 -210,883,000 -1,568,000 -203,710,000 -94,778,000 -253,062,000 -259,117,000 -405,230,000                             
      proceeds from sale of marketable debt securities
    		0 51,000 92,000 99,000 126,000 177,000 2,845,000 3,152,000 32,893,000 3,912,000 10,715,000 1,309,000 40,016,000 3,528,000 39,422,000 9,578,000 12,770,000 55,568,000 14,980,000                             
      proceeds from maturities of marketable debt securities
    		135,587,000 89,395,000 136,902,000 119,350,000 93,571,000 68,310,000 128,794,000 113,295,000 175,009,000 215,623,000 191,598,000 42,780,000 110,622,000 108,314,000 188,990,000 134,114,000 177,383,000 182,374,000 224,240,000                             
      payments for intangible asset
    		0 0 -15,000,000  0                                           
      net cash from investing activities
    		117,182,000 71,175,000 119,890,000 102,735,000 -275,502,000 60,564,000 94,435,000 -107,017,000 64,295,000 99,418,000 111,304,000 -171,599,000 -161,859,000 79,168,000 -37,362,000 69,057,000 -40,759,000 -41,246,000 -182,424,000 97,901,000 -95,758,000 -86,139,000 -95,125,000 67,266,000 79,314,000 -58,426,000 -101,193,000 73,561,000 16,205,000 -52,069,000 -71,028,000 57,104,000 29,788,000 -21,076,000 -9,400,000 -8,355,000 52,509,000 23,986,000 21,775,000 -33,560,000 -143,715,000 -111,011,000 -4,065,000 -17,021,000 -13,545,000 -27,476,000 -65,398,000 
      financing activities:
    		                                               
      proceeds from the issuance of common stock and pre-funded warrants in connection with the underwritten public offering
    		    117,000                                           
      proceeds from the issuance of common stock in connection with at-the-market offering
    		0        24,792,000           0 0   0 0 5,523,000 19,305,000                     
      proceeds from the issuance of common stock under equity plan awards, net of tax
    		2,000 3,921,000 157,000  4,057,000 4,073,000 -58,000  442,000 4,569,000 -750,000                                     
      proceeds from issuance of equity from noncontrolling interest
    		                                               
      net cash from financing activities
    		2,000 83,649,000 157,000 3,186,000 11,174,000 384,939,000 -58,000 330,610,000 25,234,000 33,020,000 -722,000 1,882,000 491,877,000 5,837,000 1,612,000 85,725,000 7,550,000 12,628,000 12,649,000 489,711,000 19,135,000 35,811,000 55,615,000 315,443,000 904,000 9,342,000 353,617,000 12,242,000 25,024,000 13,168,000 286,419,000 64,439,000 1,333,000 1,526,000 68,969,000 74,940,000 63,447,000 -25,000 314,000 887,000 288,651,000 2,595,000 175,440,000 2,697,000 60,510,000 10,000 121,754,000 
      effect of exchange rate changes on cash
    		294,000 2,914,000 1,448,000 -2,473,000 1,275,000 -648,000 -679,000 1,103,000 -716,000 -136,000 211,000 1,352,000 -1,081,000 -1,238,000 -108,000 -392,000 -479,000 448,000 -771,000 880,000 437,000 425,000 -623,000 337,000 -472,000 168,000 -198,000 145,000 30,000 -896,000 249,000 361,000 528,000 -378,000 17,000             
      net increase in cash, cash equivalents and restricted cash
    		26,055,000                    -138,153,000 37,448,000 -135,285,000  -8,760,000 -137,979,000 156,451,000   -115,875,000 126,162,000                 
      cash, cash equivalents and restricted cash at beginning of period
    		0 0 184,159,000  0 0 219,399,000  0 0 137,601,000  0 0 309,585,000  0 0 726,294,000  0 0 436,244,000  0 0 115,525,000  0 0 103,041,000                 
      cash, cash equivalents and restricted cash at end of period
    		26,055,000 49,465,000 139,179,000  -330,048,000 367,892,000 122,370,000  -29,061,000 16,141,000 91,527,000  233,592,000 6,510,000 156,206,000  -93,337,000 -93,526,000 396,402,000  -138,153,000 37,448,000 300,959,000  -8,760,000 -137,979,000 271,976,000  -27,898,000 -115,875,000 229,203,000                 
      supplemental disclosures of non-cash information:
    		                                               
      stock-based compensation capitalized into ending inventory
    		-30,000 -189,000 2,999,000  198,000 218,000 2,786,000  259,000 27,000 2,276,000                                     
      costs of property, plant and equipment included in accounts payable, accrued, and other liabilities
    		 -544,000 1,566,000   -381,000 1,280,000                                         
      change in fair value of equity investments
    		  157,000 1,548,000 -678,000 3,991,000 -3,746,000 -1,889,000 1,419,000 -261,000 334,000 -1,840,000 1,626,000 10,184,000 9,329,000 16,100,000 -25,702,000 31,046,000 20,619,000                             
      net decrease in cash, cash equivalents and restricted cash
    		  -44,980,000    -97,029,000   16,141,000 -46,074,000   6,510,000 -153,379,000  -93,337,000 -93,526,000 -329,892,000                             
      acquired in-process research and development
    		           -201,000                                    
      amortization of premium (discount) on marketable debt securities
    		                 1,571,000 940,000                             
      non-cash collaboration royalty revenue
    		           -6,058,000 -5,373,000 -5,423,000 -4,838,000 -4,741,000 -4,649,000 -4,689,000 -3,872,000 -3,567,000 -3,331,000 -3,482,000 -2,615,000                         
      deferred tax liabilities
    		                                               
      acquisition, net of cash acquired
    		           366,000                                    
      proceeds from sale of equity investments
    		               36,646,000                                
      payment for intangible asset
    		      -10,000,000 0 0   0 0 0 -30,000,000                                 
      proceeds from the sale of future royalties
    		                                               
      proceeds from the issuance of common stock and pre-funded warrants in connection with underwritten public offerings, net of issuance costs
    		                                               
      proceeds from the issuance of common stock in connection with at-the-market offering, net of issuances costs
    		                                               
      proceeds from the issuance of common stock from exercise of equity plan awards
    		                                               
      proceeds from issuance of equity interest in noncontrolling interest
    		                                               
      net increase in cash, cash equivalents, and restricted cash
    		                                               
      cash, cash equivalents, and restricted cash at beginning of year
    		                                               
      cash, cash equivalents, and restricted cash at end of year
    		                                               
      other assets
    		    12,718,000 -7,002,000 6,553,000                  70,000 65,000 945,000 -315,000 40,000 157,000 -259,000 30,000 391,000 26,000 75,000 31,000 -422,000 617,000 -1,468,000 139,000 56,000 -9,000 -7,000 -2,234,000 304,000 -579,000 2,098,000 
      acquired lease liabilities arising from obtaining right-of-use assets and property, plant, and equipment
    		                                               
      non-cash interest expense on liabilities for sales of future royalties capitalized during the year into ending property, plant and equipment
    		        1,461,000 4,149,000 3,820,000                                     
      contract liabilities
    		       0 0 0 -1,479,000 -1,479,000 -1,479,000 -1,430,000 -3,209,000   -21,177,000 -41,479,000 -36,330,000 -32,000,000 -10,385,000 145,283,000                         
      proceeds from the issuance of common stock from exercise of warrants and equity plan awards
    		               6,924,000 7,674,000 12,742,000 12,761,000 54,242,000 19,193,000 15,478,000 380,000                         
      amortization of (discount) premium on marketable debt securities
    		        -2,681,000 -3,219,000 -2,994,000                                     
      costs of pp&e included in ap, accrued, and other liabilities
    		        -4,636,000 -3,074,000 9,137,000                                     
      acquired lease liabilities arising from obtaining right-of-use assets
    		            132,000 904,000 132,000  309,000    9,733,000 -3,935,000 7,397,000  0 13,235,000 8,280,000                     
      purchase of equity investments
    		                                               
      proceeds from the issuance of common stock in connection with underwritten public offerings
    		                       0 0 0 330,415,000                     
      proceeds from the issuance of common stock in connection with the license agreement
    		                   0 0 0 55,268,000                         
      amortization of premium on marketable debt securities
    		            969,000 1,486,000 1,894,000                                 
      non-cash interest expense on liabilities related to the sale of future royalties
    		                                               
      proceeds from sale of future royalties
    		                                               
      proceeds from the issuance of common stock from equity plan awards
    		            1,074,000 5,983,000 1,755,000                                 
      non-cash interest expense on liabilities related to the sale of future royalties capitalized into ending property, plant and equipment
    		                                               
      non-cash interest expense on liability related to the sale of future royalties
    		             6,052,000 6,584,000 3,804,000 8,683,000 8,517,000 8,418,000 8,198,000 8,582,000 8,429,000 8,082,000                         
      non-cash interest expense on liability related to the sale of future royalties capitalized into ending property, plant and equipment
    		             2,680,000 2,101,000                                 
      purchase of mutual funds related to nonqualified deferred compensation plan
    		              -2,458,000                                 
      contract assets and liabilities
    		                                               
      receivable related to the daiichi sankyo license agreement
    		                     117,077,000 -125,550,000                         
      purchase of property and equipment
    		                  -16,414,000  -3,780,000 -4,083,000 -14,096,000 -11,500,000 -5,033,000 -5,240,000 -3,059,000 -1,192,000 -1,032,000 -1,377,000 -475,000 -899,000 -1,033,000 -376,000 -485,000 -666,000 -3,001,000 -5,044,000 -1,477,000 -1,923,000 -1,978,000 -595,000 -459,000 -453,000 -439,000 -688,000 -569,000 
      foreign currency remeasurement (gain) loss
    		                           -544,000 7,000 1,073,000 4,773,000                 
      gain from sale of priority review vouchers
    		                            0                   
      proceeds from sale of equity investment
    		                                               
      proceeds from sale of priority review vouchers
    		                           0 0                   
      amortization of premium (discount) on investment securities
    		                           -809,000 -919,000 -674,000 -239,000      1,015,000 1,387,000 1,828,000  1,467,000 1,268,000 965,000  1,048,000 917,000 479,000 
      foreign currency remeasurement loss
    		                      474,000  358,000 -22,000 589,000                     
      change in fair value of investments in equity securities
    		                                               
      right-of-use assets
    		                    -508,000 -1,231,000 -5,522,000  1,619,000 -10,320,000 -6,880,000                     
      lease liabilities
    		                    920,000 1,169,000 5,511,000 -1,519,000 -1,451,000 11,710,000 6,812,000                     
      purchase of investments
    		                    -192,193,000 -171,102,000 -285,229,000 -82,557,000 -149,179,000 -200,354,000 -260,734,000 -9,747,000 -91,366,000 -147,853,000 -260,830,000 3,000 -23,282,000 -119,681,000 -87,527,000 -130,967,000 -88,400,000 -104,993,000 -118,130,000 -146,905,000 -234,917,000 -165,150,000 -77,254,000 -48,030,000 -31,644,000 -41,300,000 -87,998,000 
      purchase of investments in equity securities
    		                                               
      purchase of convertible notes receivable
    		                                               
      proceeds from the sale of investments
    		                    11,540,000 12,250,000 16,600,000  12,500,000 0 22,600,000  2,701,000    6,000,000 9,227,000 12,415,000  39,957,000 42,838,000 11,494,000  43,047,000 7,497,000 12,766,000     
      proceeds from maturities of investments
    		                    93,450,000 86,396,000 187,600,000 153,705,000 221,026,000 161,507,000 140,000,000 84,500,000 105,902,000 51,885,000 60,277,000 70,799,000 48,103,000 89,753,000 64,977,000 77,011,000 103,612,000 91,185,000 131,431,000 90,630,000 49,062,000 47,118,000 62,240,000 29,463,000 15,535,000 14,512,000 23,462,000 
      payment for intangible assets
    		                                               
      principal repayments of financing leases
    		                    -58,000 -58,000 -33,000                         
      amortization of discount on investment securities
    		                     150,000 -299,000  -1,971,000 -2,121,000 -839,000                     
      change in fair value of investment in arcturus equity securities
    		                     -95,200,000 -7,668,000 -1,419,000 -2,166,000                       
      purchase of investment in arcturus equity securities
    		                       0 0                       
      right-of-use lease assets
    		                                               
      proceeds from sale of investments
    		                                               
      proceeds from the issuance of common stock under equity plan awards
    		                                               
      repayment of note payable
    		                                               
      supplemental disclosures of non-cash investing and financing information:
    		                                               
      acquired lease liabilities arising from obtaining right-of-use lease assets
    		                                               
      costs of property and equipment included in accounts payable and other liabilities
    		                                               
      fair value of vested stock options assumed in acquisition
    		                                               
      prepaid expenses and other current assets
    		                        -2,689,000 -1,906,000 -2,359,000 6,099,000 2,375,000 -17,319,000 -5,063,000 -4,098,000 291,000 -461,000 930,000 -1,314,000 -1,279,000 -526,000 -4,028,000 -736,000 -2,894,000 -2,553,000 -948,000 -382,000 -602,000 -706,000 -2,391,000 
      accounts payable
    		                        3,910,000 -3,493,000 -151,000 3,965,000 -1,969,000 2,693,000 -1,317,000 -420,000 -2,474,000 3,364,000 2,989,000 -1,340,000 1,017,000 187,000 2,638,000 -1,438,000 -5,321,000 4,340,000 437,000 484,000 733,000 -98,000 2,058,000 
      accrued liabilities and other liabilities
    		                        7,209,000 9,498,000 -12,930,000 3,276,000 2,752,000 5,544,000 -12,583,000 -3,081,000 4,178,000 6,745,000 -12,470,000 9,601,000 20,406,000 4,051,000 -1,869,000  6,986,000 4,115,000 664,000  1,490,000 2,415,000 -1,186,000 
      proceeds from the issuance of common stock from equity plan awards, net of tax
    		                        904,000 3,819,000 3,897,000                     
      gain from sale of priority review voucher
    		                              -130,000,000                 
      proceeds from sale of priority review voucher
    		                              130,000,000                 
      gain on sale of priority review voucher
    		                                               
      proceeds from the issuance of common stock in connection with collaboration agreement
    		                                               
      stock-based compensation capitalized into inventory
    		                                               
      costs of property and equipment included in accounts payable and accrued liabilities
    		                                               
      tenant improvement allowance
    		                                               
      proceeds from issuance of common stock in connection with a public offering
    		                            0 0 270,969,000                 
      proceeds from issuance of common stock in connection with at-the-market offering
    		                            15,837,000 -19,000 11,808,000  0 25,000 67,591,000             
      proceeds from issuance of common stock from equity awards
    		                            9,187,000 13,187,000 3,642,000  1,333,000 1,501,000 1,378,000             
      amortization of premium on investment securities
    		                               255,000 400,000 502,000 549,000             
      non-cash license fee from collaboration arrangement
    		                                   0            
      decrease (increase) in restricted cash
    		                                           0    
      net increase in cash and cash equivalents
    		                               40,081,000    18,840,000 87,211,000 -15,694,000 -22,806,000 -73,117,000 114,335,000 -125,689,000 153,716,000 -29,063,000 35,935,000 -37,995,000 48,020,000 
      cash and cash equivalents at beginning of year
    		                                               
      cash and cash equivalents at end of year
    		                                               
      foreign currency remeasurement gain
    		                                -3,827,000 -3,956,000 -648,000             
      increase in restricted cash
    		                                0 1,000 1,220,000 0 341,000 0 -1,543,000  1,071,000 119,000 -1,358,000   0 -293,000 
      proceeds from issuance of common stock in connection with collaboration agreement
    		                                               
      cash and cash equivalents at beginning of period
    		                                0 0 161,120,000  0 0 93,569,000  0 0 24,324,000  0 0 7,427,000 
      cash and cash equivalents at end of period
    		                                -30,344,000 -68,750,000 159,501,000  87,211,000 -15,694,000 70,763,000  114,335,000 -125,689,000 178,040,000  35,935,000 -37,995,000 55,447,000 
      net decrease in cash and cash equivalents
    		                                 -68,750,000 -1,619,000             
      revaluation of convertible preferred stock warrant liability
    		                                           0 0 0 3,324,000 
      proceeds from the issuance of common stock from equity awards
    		                                               
      payment of preferred stock dividend
    		                                           0 0 0 -4,346,000 
      reclassification of warrant liability to equity upon conversion to common stock warrants
    		                                               
      conversion of series a and series b preferred stock to common stock
    		                                           0 0 0 129,360,000 
      proceeds from issuance of common stock in connection with underwritten public offerings
    		                                               
      proceeds from issuance of common stock
    		                                     -25,000 314,000 887,000        
      accrued expenses and other liabilities
    		                                               
      costs of fixed assets included in accounts payable and accrued liabilities
    		                                               
      costs of fixed assets included in accounts payable
    		                                               
      and accrued liabilities
    		                                        -24,000       
      reclassification of warrant liability to equity upon conversion to
    		                                               
      common stock warrants
    		                                            0 0 6,743,000 
      proceeds from issuance of common stock, net of issuance costs
    		                                         2,595,000 175,440,000     
      accrued expenses, deferred rent and other liabilities
    		                                               
      proceeds from issuance of convertible preferred stock
    		                                               
      proceeds from issuance of promissory notes
    		                                               
      issuance of series a redeemable convertible preferred stock in lieu of cash dividend
    		                                               
      sale of investments
    		                                               
      net proceeds from issuance of common stock, net of issuance costs
    		                                               
      net proceeds from issuance of common stock
    		                                             10,000 126,100,000 
      noncash interest expense
    		                                               
      net proceeds from issuance of convertible preferred stock
    		                                               
      issuance of convertible preferred stock warrants
    		                                               
      issuance of series a redeemable convertible preferred stock in lieu
    		                                               
      of cash dividend
    		                                               
      conversion of interest accrued on promissory notes into series a
    		                                               
      redeemable convertible preferred stock
    		                                               
      conversion of promissory notes into series a redeemable
    		                                               
      convertible preferred stock
    		                                               
    The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.