7Baggers
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 
      
    		                                                
      assets
    		                                                
      current assets:
    		                                                
      cash and cash equivalents
    		202,510,000 176,306,000 127,055,000 173,729,000 150,619,000 480,693,000 112,250,000 213,584,000 72,575,000 102,059,000 85,768,000 132,944,000 391,651,000 159,868,000 153,988,000 307,584,000 197,538,000 290,875,000 383,794,000 713,526,000 197,486,000 335,639,000 298,190,000 433,584,000 122,577,000 131,337,000 269,712,000 113,432,000 82,956,000 110,854,000 226,730,000 100,488,000 60,407,000 90,751,000 159,501,000 161,120,000 142,280,000 55,069,000 70,763,000 93,569,000 166,686,000 52,351,000 178,040,000 24,324,000 53,387,000 17,452,000 55,447,000 7,427,000 
      marketable debt securities
    		222,738,000 311,279,000 367,385,000 436,296,000 470,989,000 283,128,000 299,830,000 363,625,000 369,519,000 449,922,000 543,586,000 614,818,000 497,024,000 382,927,000 444,333,000 432,612,000 539,579,000 554,881,000 581,614,000 488,007,000                             
      accounts receivable
    		112,543,000 124,464,000 98,839,000 121,801,000 93,301,000 105,982,000 100,253,000 73,390,000 79,263,000 70,523,000 42,991,000 40,445,000 31,164,000 37,207,000 28,369,000 28,432,000 25,383,000 24,720,000 25,032,000 23,093,000 27,762,000 14,893,000 29,327,000 32,844,000 23,121,000 20,901,000 15,628,000 12,740,000 9,155,000 17,425,000 3,671,000 5,172,000                 
      inventory
    		52,200,000 46,498,000 46,031,000 45,007,000 43,334,000 40,137,000 35,907,000 33,969,000 31,802,000 28,256,000 26,616,000 26,766,000 21,849,000 21,079,000 17,809,000 16,231,000 15,191,000 15,083,000 12,462,000 13,048,000 14,457,000 11,061,000 11,375,000 11,546,000 14,138,000 13,632,000 10,948,000 7,065,000 5,556,000 3,342,000 2,068,000 757,000                 
      prepaid expenses and other assets
    		53,215,000 61,241,000 59,845,000 40,290,000                                             
      total current assets
    		643,206,000 719,788,000 699,155,000 817,123,000 799,608,000 964,640,000 595,967,000 732,184,000 599,188,000 702,137,000 766,336,000 883,899,000 1,012,668,000 678,542,000 707,519,000 856,604,000 846,884,000 949,492,000 1,070,936,000 1,295,304,000 872,003,000 906,039,000 894,318,000 851,017,000 613,486,000 699,431,000 786,887,000 522,369,000 567,480,000 604,743,000 581,580,000 269,583,000 390,903,000 419,794,000 444,685,000 401,695,000 416,785,000 411,084,000 430,234,000 450,207,000 460,707,000 336,530,000 350,514,000 193,416,000 206,741,000 158,216,000 169,636,000 55,225,000 
      property, plant, and equipment
    		249,961,000 255,763,000 260,906,000 265,929,000 272,448,000 278,707,000 285,111,000 290,566,000 296,811,000 288,990,000 277,873,000 259,726,000 234,614,000 207,381,000 177,073,000 141,247,000 119,069,000 104,568,000  73,515,000                             
      intangible assets
    		172,943,000 174,733,000 176,524,000 178,314,000 164,942,000 166,243,000 165,045,000 166,271,000 157,302,000 158,237,000 159,171,000 160,105,000 158,401,000 159,196,000 159,992,000 130,788,000 130,869,000 130,950,000 131,031,000 131,113,000 131,194,000 131,275,000 129,000,000 129,000,000 129,020,000 129,069,000 129,086,000 129,223,000 130,232,000 132,776,000 137,122,000 141,545,000                 
      goodwill
    		44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000 44,406,000                 
      other assets
    		57,862,000 60,121,000 62,373,000 62,680,000 41,365,000 54,700,000 47,727,000 47,616,000 27,896,000 26,489,000 22,259,000 16,846,000 18,285,000 21,144,000 21,218,000 20,558,000 16,419,000 12,668,000 8,929,000 8,812,000 5,092,000 2,627,000 4,862,000 3,471,000 3,111,000 3,181,000 2,660,000 3,514,000 3,199,000 3,239,000 1,574,000 1,315,000 1,345,000 1,736,000 1,762,000 1,837,000 1,868,000 1,446,000 2,063,000 595,000 734,000 790,000 781,000 774,000 825,000 1,129,000 550,000 2,648,000 
      total assets
    		1,190,445,000 1,306,265,000 1,311,927,000 1,503,456,000 1,538,363,000 1,618,437,000 1,307,080,000 1,491,013,000 1,238,140,000 1,311,310,000 1,383,404,000 1,545,444,000 1,618,474,000 1,320,627,000 1,384,029,000 1,522,397,000 1,484,801,000 1,512,444,000 1,597,763,000 1,759,555,000 1,268,385,000 1,314,041,000 1,233,140,000 1,135,496,000 879,944,000 958,927,000 1,007,759,000 719,558,000 765,145,000 806,022,000 817,350,000 490,753,000 435,047,000 497,542,000 545,822,000 540,626,000 515,166,000 481,951,000 524,184,000 559,569,000 602,130,000 343,004,000 355,840,000 197,967,000 210,931,000 162,586,000 172,707,000 59,649,000 
      liabilities, noncontrolling interest and stockholders' equity
    		                                                
      current liabilities:
    		                                                
      accounts payable
    		40,573,000 34,242,000 47,450,000 38,756,000 35,990,000 59,807,000 40,972,000 42,114,000 33,357,000 42,115,000 58,981,000 43,274,000 23,533,000 34,213,000 23,685,000 17,138,000 15,575,000 21,790,000 15,744,000 12,923,000 10,850,000 9,014,000 14,405,000 12,871,000 13,460,000 8,743,000 12,664,000 12,275,000 8,198,000 10,314,000 7,569,000 8,886,000 9,288,000 11,876,000 8,345,000 5,364,000 6,616,000 6,954,000 6,012,000 2,942,000 4,422,000 10,171,000 5,755,000 4,857,000 4,161,000 3,590,000 3,495,000 1,437,000 
      accrued liabilities
    		220,526,000 180,792,000 173,007,000 240,973,000 185,028,000 154,421,000 149,133,000 196,486,000 178,622,000 167,656,000 144,404,000 204,678,000 189,051,000 170,355,000 126,356,000 145,555,000 109,660,000 91,060,000 82,699,000 108,491,000 79,653,000 71,887,000 67,719,000 83,194,000 69,557,000 59,264,000 48,957,000 62,450,000 58,483,000 55,735,000 49,291,000 61,427,000 54,278,000 50,130,000 42,773,000 54,554,000 43,487,000 24,714,000 23,565,000 24,784,000 20,148,000 12,716,000 8,398,000 7,575,000 6,831,000 5,278,000 3,238,000 4,406,000 
      lease liabilities
    		12,142,000 11,766,000 10,487,000 10,297,000 10,424,000 11,717,000 12,781,000 12,595,000 12,067,000 10,884,000 11,261,000 11,779,000 11,819,000 11,631,000 11,323,000 11,066,000 10,698,000 10,305,000 9,380,000 8,976,000                             
      liabilities for sales of future royalties
    		65,545,000 63,863,000 57,376,000 49,847,000 48,731,000 46,921,000 42,689,000 29,242,000 29,932,000 23,724,000 3,533,000 875,439,000                                     
      other liabilities
    		1,236,000 2,581,000 3,348,000 4,280,000 4,835,000 15,197,000 14,479,000 12,205,000 10,230,000 10,392,000 9,257,000 4,820,000 4,050,000 3,768,000 3,392,000 1,005,000 471,000           4,759,000 4,702,000 4,836,000 4,944,000 5,119,000 5,228,000 5,414,000 5,589,000 6,393,000 8,845,000 6,073,000 4,480,000 561,000 634,000 684,000 478,000 505,000 533,000 560,000 182,000 200,000 
      total current liabilities
    		340,022,000 293,244,000 291,668,000 344,153,000 285,008,000 272,866,000 245,575,000 280,437,000 253,978,000 244,379,000 218,179,000 261,210,000 227,361,000 220,636,000 167,231,000 181,368,000 135,933,000 127,067,000 127,044,000 189,609,000 201,186,000 219,729,000 196,858,000 103,300,000 90,307,000 75,006,000 66,880,000 74,725,000 66,681,000 66,049,000 57,583,000 71,014,000 64,261,000 62,675,000 51,755,000 60,259,000 50,431,000 31,983,000 29,880,000 27,918,000 24,733,000 23,042,000 14,243,000 12,517,000 11,072,000 8,943,000 6,811,000 5,921,000 
      deferred tax liabilities
    		30,058,000 30,058,000 30,058,000 30,058,000 30,058,000 30,058,000 30,058,000 30,058,000 31,667,000 31,667,000 31,667,000 31,667,000 33,306,000 33,306,000 33,306,000 33,306,000 33,306,000 33,306,000 33,306,000 33,306,000 33,306,000 33,306,000 33,306,000 33,306,000 31,166,000 31,166,000 31,166,000 31,166,000 31,166,000 31,166,000 31,166,000 31,166,000                 
      total liabilities
    		1,174,286,000 1,147,979,000 1,160,681,000 1,241,159,000 1,184,536,000 1,186,019,000 1,166,816,000 1,215,599,000 1,206,426,000 1,182,280,000 1,162,923,000 1,192,950,000 1,149,645,000 642,554,000 587,605,000 599,836,000 551,127,000 540,273,000 543,181,000 605,180,000 602,194,000 618,454,000 623,994,000 481,732,000 152,679,000 139,140,000 121,030,000 110,650,000 102,549,000 102,051,000 93,693,000 107,299,000 69,489,000 68,089,000 57,344,000 66,652,000 59,276,000 38,056,000 34,360,000 28,479,000 25,367,000 23,726,000 14,721,000 13,022,000 11,605,000 9,503,000 6,993,000 9,540,000 
      noncontrolling interest
    		7,000,000 7,000,000 7,000,000 7,000,000 7,000,000                                            
      stockholders’ equity:
    		                                                
      preferred stock, par value of 0.001 per share—25,000,000 shares authorized; nil outstanding in 2025 and in 2024
    		                                                
      common stock
    		96,000 96,000 94,000 92,000 92,000 92,000 83,000 82,000    70,000    69,000    67,000    58,000    51,000    44,000    41,000    39,000 39,000 36,000 36,000 32,000 32,000 30,000 30,000  
      treasury stock
    		-7,991,000 -7,991,000 -7,566,000 -3,593,000 -3,555,000 -3,395,000 -3,332,000 -432,000 -381,000 -381,000 -356,000                                      
      deferred compensation obligation
    		7,991,000 7,991,000 7,566,000 3,593,000 3,555,000 3,395,000 3,332,000 432,000 381,000 381,000 356,000                                      
      additional paid-in capital
    		4,411,531,000 4,374,333,000 4,252,417,000 4,212,692,000 4,169,298,000 4,123,364,000 3,698,957,000 3,662,346,000 3,298,357,000 3,236,879,000 3,169,371,000 3,140,019,000 3,108,170,000 3,071,000,000 3,028,829,000 2,997,497,000 2,884,695,000 2,850,016,000 2,810,176,000 2,773,195,000 2,260,682,000 2,220,963,000 2,162,667,000 2,086,863,000 2,066,483,000 2,045,685,000 2,013,859,000 1,639,773,000 1,605,412,000 1,559,722,000 1,526,972,000 1,221,762,000 1,123,861,000 1,105,348,000 1,087,028,000 1,003,561,000 915,084,000 837,943,000 827,109,000 816,578,000 806,202,000 509,658,000 501,597,000 324,128,000 321,714,000 259,555,000 258,599,000  
      accumulated other comprehensive income
    		820,000   -643,000 896,000 -1,095,000 -431,000 647,000        -1,404,000 54,000 232,000 56,000 689,000 1,013,000 1,284,000    255,000      -5,680,000 -7,404,000 -4,223,000 231,000 905,000 12,000 252,000 92,000     -174,000 -118,000 -48,000 -46,000 11,000 
      accumulated deficit
    		-4,403,288,000 -4,222,875,000 -4,107,924,000 -3,956,844,000 -3,823,459,000 -3,689,943,000 -3,558,345,000 -3,387,661,000 -3,264,471,000 -3,104,822,000 -2,944,994,000 -2,781,022,000 -2,629,189,000 -2,384,083,000 -2,225,921,000 -2,073,601,000 -1,951,143,000 -1,878,145,000 -1,755,717,000 -1,619,576,000 -1,595,565,000 -1,526,720,000 -1,552,035,000 -1,433,010,000 -1,339,205,000 -1,226,211,000 -1,127,039,000 -1,030,283,000 -942,457,000 -855,147,000 -802,419,000 -832,672,000 -750,941,000 -671,714,000 -598,823,000 -530,533,000 -459,246,000 -394,339,000 -337,416,000 -284,659,000 -229,439,000 -190,207,000 -160,420,000 -139,041,000 -122,302,000 -106,454,000   
      total stockholders’ equity
    		9,159,000 151,286,000 144,246,000 255,297,000 346,827,000 432,418,000 140,264,000 275,414,000 31,714,000 129,030,000 220,481,000 352,494,000 468,829,000 678,073,000 796,424,000 922,561,000 933,674,000 972,171,000 1,054,582,000 1,154,375,000 666,191,000 695,587,000 609,146,000 653,764,000 727,265,000 819,787,000 886,729,000 608,908,000 662,596,000 703,971,000 723,657,000 383,454,000 365,558,000 429,453,000 488,478,000 473,974,000 455,890,000 443,895,000 489,824,000 531,090,000 576,763,000 319,278,000 341,119,000 184,945,000 199,326,000 153,083,000 165,714,000  
      total liabilities, noncontrolling interest and stockholders’ equity
    		1,190,445,000 1,306,265,000 1,311,927,000 1,503,456,000 1,538,363,000                                            
      accumulated other comprehensive loss
    		 -268,000 -341,000      -2,244,000 -3,098,000 -3,967,000 -6,573,000 -10,222,000 -8,914,000 -6,554,000        -1,545,000 -147,000 -71,000  -148,000 -633,000 -410,000 -654,000 -946,000         -868,000 -39,000 -209,000 -94,000      
      liabilities and stockholders' equity
    		                                                
      commitments and contingencies
    		                                                
      preferred stock, par value of 0.001 per share—25,000,000 shares authorized; nil outstanding in 2024 and in 2023
    		                                                
      total liabilities and stockholders’ equity
    		     1,618,437,000 1,307,080,000 1,491,013,000 1,238,140,000 1,311,310,000 1,383,404,000 1,545,444,000 1,618,474,000 1,320,627,000 1,384,029,000 1,522,397,000 1,484,801,000 1,512,444,000 1,597,763,000 1,759,555,000 1,268,385,000 1,314,041,000 1,233,140,000 1,135,496,000 879,944,000 958,927,000 1,007,759,000 719,558,000 765,145,000 806,022,000 817,350,000 490,753,000 435,047,000 497,542,000 545,822,000 540,626,000 515,166,000 481,951,000 524,184,000 559,569,000 602,130,000 343,004,000 355,840,000      
      contract liabilities
    		           1,479,000 2,958,000 4,437,000 5,867,000 7,609,000  3,912,000 19,221,000 59,219,000 102,898,000                            
      preferred stock, par value of 0.001 per share—25,000,000 shares authorized; nil outstanding in 2023 and in 2022
    		                                                
      prepaid expenses and other current assets
    		        46,029,000 51,377,000 67,375,000 68,926,000 70,980,000 77,461,000 63,020,000 71,745,000 69,193,000 63,933,000 68,034,000 57,630,000 64,264,000 58,196,000 64,788,000 51,397,000 49,169,000 46,612,000 44,995,000 42,858,000 49,671,000 36,844,000 33,953,000 28,700,000 19,376,000 19,685,000 19,224,000 20,136,000 18,944,000 17,799,000 17,088,000 13,060,000 12,324,000 9,430,000 6,877,000 5,929,000 5,547,000 4,945,000 4,239,000 1,848,000 
      equity investments
    		        4,039,000 5,458,000 5,197,000 5,531,000 13,786,000 15,412,000 25,596,000 34,925,000 86,215,000 103,710,000 134,756,000 155,375,000                             
      right-of-use assets
    		        26,427,000 19,222,000 22,949,000 25,961,000 28,751,000 31,245,000 32,699,000 34,936,000 36,696,000 38,619,000 38,511,000 40,524,000 37,597,000 37,067,000 35,827,000  31,711,000 33,356,000 23,024,000                      
      preferred stock — 25,000,000 shares authorized; nil outstanding as of september 30, 2023 and december 31, 2022
    		                                                
      common stock — 250,000,000 shares authorized; 72,174,307 and 70,197,297 shares issued and outstanding as of september 30, 2023 and december 31, 2022, respectively
    		        72,000                                        
      preferred stock — 25,000,000 shares authorized; nil outstanding as of june 30, 2023 and december 31, 2022
    		                                                
      common stock — 250,000,000 shares authorized; 71,465,424 and 70,197,297 shares issued and outstanding as of june 30, 2023 and december 31, 2022, respectively
    		         71,000                                       
      preferred stock — 25,000,000 shares authorized; nil outstanding as of march 31, 2023 and december 31, 2022
    		                                                
      common stock — 250,000,000 shares authorized; 70,660,249 and 70,197,297 shares issued and outstanding as of march 31, 2023 and december 31, 2022, respectively
    		          71,000                                      
      preferred stock, par value of 0.001 per share—25,000,000 shares authorized; nil outstanding as of december 31, 2022 and december 31, 2021
    		                                                
      liabilities and stockholders’ equity
    		                                                
      liabilities related to the sale of future royalties
    		            862,063,000                                    
      preferred stock — 25,000,000 shares authorized; nil outstanding as of september 30, 2022 and december 31, 2021
    		                                                
      common stock — 250,000,000 shares authorized; 70,079,777 and 69,344,998 shares issued and outstanding as of september 30, 2022 and december 31, 2021, respectively
    		            70,000                                    
      liability related to the sale of future royalties
    		             358,942,000 355,633,000 351,786,000 348,073,000 344,039,000 340,211,000 335,665,000 331,034,000 325,783,000 320,836,000 315,369,000                         
      preferred stock — 25,000,000 shares authorized; nil outstanding as of june 30, 2022 and december 31, 2021
    		                                                
      common stock — 250,000,000 shares authorized; 70,010,398 and 69,344,998 shares issued and outstanding as of june 30, 2022 and december 31, 2021, respectively
    		             70,000                                   
      preferred stock — 25,000,000 shares authorized; nil outstanding as of march 31, 2022 and december 31, 2021
    		                                                
      common stock — 250,000,000 shares authorized; 69,796,940 and 69,344,998 shares issued and outstanding as of march 31, 2022 and december 31, 2021, respectively
    		              70,000                                  
      preferred stock, par value of 0.001 per share—25,000,000 shares authorized; nil outstanding as of december 31, 2021 and december 31, 2020
    		                                                
      preferred stock — 25,000,000 shares authorized; nil outstanding as of september 30, 2021 and december 31, 2020
    		                                                
      common stock — 250,000,000 shares authorized; 67,961,963 and 66,818,520 shares issued and outstanding as of september 30, 2021 and december 31, 2020, respectively
    		                68,000                                
      preferred stock — 25,000,000 shares authorized; nil outstanding as of june 30, 2021 and december 31, 2020
    		                                                
      common stock — 250,000,000 shares authorized; 67,764,950 and 66,818,520 shares issued and outstanding as of june 30, 2021 and december 31, 2020, respectively
    		                 68,000                               
      property and equipment
    		                  87,570,000  48,773,000 48,339,000 47,596,000 44,348,000 31,877,000 25,317,000 21,696,000 20,046,000 19,828,000 20,858,000 20,830,000 21,837,000 16,030,000 16,405,000 16,517,000 17,055,000 18,226,000 17,054,000 13,418,000 7,373,000 6,285,000 4,772,000 3,514,000 3,033,000 2,621,000 2,497,000 1,777,000 1,325,000 
      preferred stock — 25,000,000 shares authorized; nil outstanding as of march 31, 2021 and december 31, 2020
    		                                                
      common stock — 250,000,000 shares authorized; 67,439,477 and 66,818,520 shares issued and outstanding as of march 31, 2021 and december 31, 2020, respectively
    		                  67,000                              
      preferred stock, par value of 0.001 per share—25,000,000 shares authorized; nil outstanding as of december 31, 2020 and 2019
    		                                                
      short-term investments
    		                    568,034,000 477,777,000 365,088,000 321,646,000 404,481,000 486,949,000 445,604,000 346,274,000 420,142,000 436,278,000 314,616,000 134,005,000 310,659,000 308,897,000 265,689,000 219,028,000 254,150,000 336,734,000 341,092,000 343,428,000 281,697,000 273,678,000 164,526,000 163,163,000 147,807,000 135,819,000 109,950,000 45,950,000 
      investments in equity securities
    		                    129,320,000                            
      long-term investments
    		                     4,068,000 41,711,000 5,174,000       29,907,000 9,975,000 24,964,000 57,802,000 80,862,000 117,963,000 76,211,000 50,021,000 75,932,000 99,259,000 133,492,000        
      short-term lease liabilities
    		                    7,785,000 7,258,000 7,487,000 7,235,000 7,290,000 6,999,000 5,259,000                      
      long-term lease liabilities
    		                    36,668,000 36,308,000 34,958,000 29,757,000 31,206,000 32,968,000 22,984,000                      
      preferred stock — 25,000,000 shares authorized; nil outstanding as of september 30, 2020 and december 31, 2019
    		                                                
      common stock — 250,000,000 shares authorized; 60,815,690 and 57,838,220 shares issued and outstanding as of september 30, 2020 and december 31, 2019, respectively
    		                    61,000                            
      receivable related to daiichi sankyo license agreements
    		                     8,473,000                           
      investment in arcturus equity securities
    		                     140,220,000 35,420,000 27,752,000 26,333,000 24,167,000                       
      short-term contract liability
    		                     131,570,000 107,247,000                          
      long-term contract liability
    		                     3,328,000 38,036,000                          
      preferred stock — 25,000,000 shares authorized; nil outstanding as of june 30, 2020 and december 31, 2019
    		                                                
      common stock — 250,000,000 shares authorized; 60,413,756 and 57,838,220 shares issued and outstanding as of june 30, 2020 and december 31, 2019, respectively
    		                     60,000                           
      receivable related to daiichi sankyo license agreement
    		                      125,550,000                          
      preferred stock — 25,000,000 shares authorized; nil outstanding as of march 31, 2020 and december 31, 2019
    		                                                
      common stock — 250,000,000 shares authorized; 59,488,873 and 57,838,220 shares issued and outstanding as of march 31, 2020 and december 31, 2019, respectively
    		                      59,000                          
      right-of-use lease assets
    		                       30,328,000                         
      preferred stock, par value of 0.001 per share—25,000,000 shares authorized; nil outstanding as of december 31, 2019 and 2018
    		                                                
      preferred stock — 25,000,000 shares authorized; nil outstanding as of september 30, 2019 and december 31, 2018
    		                                                
      common stock — 250,000,000 shares authorized; 57,749,890 and 50,860,588 shares issued and outstanding as of september 30, 2019 and december 31, 2018, respectively
    		                        58,000                        
      preferred stock — 25,000,000 shares authorized; nil outstanding as of june 30, 2019 and december 31, 2018
    		                                                
      common stock — 250,000,000 shares authorized; 57,665,375 and 50,860,588 shares issued and outstanding as of june 30, 2019 and december 31, 2018, respectively
    		                         58,000                       
      preferred stock — 25,000,000 shares authorized; nil outstanding as of march 31, 2019 and
    		                                                
      december 31, 2018
    		                                                
      common stock — 250,000,000 shares authorized; 57,303,888 and 50,860,588 shares issued
    		                                                
      and outstanding as of march 31, 2019 and december 31, 2018, respectively
    		                          57,000                      
      preferred stock, par value of 0.001 per share—25,000,000 shares authorized; nil outstanding as of december 31, 2018 and 2017
    		                                                
      preferred stock — 25,000,000 shares authorized; nil outstanding as of september 30, 2018 and
    		                                                
      december 31, 2017
    		                                                
      common stock — 250,000,000 shares authorized; 50,533,070 and 44,167,071 shares issued
    		                                                
      and outstanding as of september 30, 2018 and december 31, 2017, respectively
    		                            51,000                    
      preferred stock — 25,000,000 shares authorized; nil outstanding as of june 30, 2018 and
    		                                                
      common stock — 250,000,000 shares authorized; 50,116,056 and 44,167,071 shares issued
    		                                                
      and outstanding as of june 30, 2018 and december 31, 2017, respectively
    		                             50,000                   
      restricted cash
    		                              542,000 461,000 461,000 461,000 271,000 1,411,000 1,411,000 1,482,000 1,291,000 150,000 912,000 1,071,000 1,071,000 744,000 744,000 744,000 744,000 451,000 
      deferred rent—current portion
    		                              723,000 701,000 695,000 669,000 637,000 341,000 328,000 315,000 303,000 192,000 163,000 155,000 90,000 85,000 80,000 75,000 78,000 78,000 
      preferred stock — 25,000,000 shares authorized; nil outstanding as of march 31, 2018 and
    		                                                
      common stock — 250,000,000 shares authorized; 49,665,203 and 44,167,071 shares issued
    		                                                
      and outstanding as of march 31, 2018 and december 31, 2017, respectively
    		                              50,000                  
      preferred stock, par value of 0.001 per share—25,000,000 shares authorized; nil outstanding as of december 31, 2017 and 2016
    		                                                
      preferred stock — 25,000,000 shares authorized; nil outstanding as of september 30, 2017 and
    		                                                
      december 31, 2016
    		                                                
      common stock — 250,000,000 shares authorized; 42,488,312 and 41,240,230 shares issued
    		                                                
      and outstanding as of september 30, 2017 and december 31, 2016, respectively
    		                                42,000                
      preferred stock — 25,000,000 shares authorized; nil outstanding as of june 30, 2017 and
    		                                                
      common stock — 250,000,000 shares authorized; 42,428,124 and 41,240,230 shares issued
    		                                                
      and outstanding as of june 30, 2017 and december 31, 2016, respectively
    		                                 42,000               
      preferred stock — 25,000,000 shares authorized; nil outstanding as of march 31, 2017 and
    		                                                
      common stock — 250,000,000 shares authorized; 42,273,429 and 41,240,230 shares issued
    		                                                
      and outstanding as of march 31, 2017 and december 31, 2016, respectively
    		                                  42,000              
      preferred stock, par value of 0.001 per share—25,000,000 shares authorized; nil outstanding as of december 31, 2016 and 2015
    		                                                
      preferred stock — 25,000,000 shares authorized; nil outstanding as of september 30, 2016 and
    		                                                
      december 31, 2015
    		                                                
      common stock — 250,000,000 shares authorized; 40,052,032 and 38,882,394 shares issued
    		                                                
      and outstanding as of september 30, 2016 and december 31, 2015, respectively
    		                                    40,000            
      preferred stock — 25,000,000 shares authorized; nil outstanding as of june 30, 2016 and december 31, 2015
    		                                                
      common stock — 250,000,000 shares authorized; 39,046,247 and 38,882,394 shares issued and outstanding as of june 30, 2016 and december 31, 2015, respectively
    		                                     39,000           
      preferred stock — 25,000,000 shares authorized; nil outstanding as of march 31, 2016 and december 31, 2015
    		                                                
      common stock — 250,000,000 shares authorized; 38,992,346 and 38,882,394 shares issued and outstanding as of march 31, 2016 and december 31, 2015, respectively
    		                                      39,000          
      preferred stock, par value of 0.001 per share—25,000,000 shares authorized; nil outstanding as of december 31, 2015 and 2014
    		                                                
      preferred stock, par value of 0.001 per share—25,000,000 shares authorized; nil outstanding as of september 30, 2015 and december 31, 2014
    		                                                
      preferred stock, par value of 0.001 per share—25,000,000 shares authorized; nil outstanding as of june 30, 2015 and december 31, 2014
    		                                                
      preferred stock, par value of 0.001 per share—25,000,000 shares authorized; nil outstanding as of march 31, 2015 and december 31, 2014
    		                                                
      liabilities, convertible preferred stock and stockholders’ equity
    		                                                
      convertible preferred stock warrant liability
    		                                               3,419,000 
      series a redeemable convertible preferred stock, par value of 0.001 per share — nil and 35,377,556 shares authorized as of december 31, 2014 and 2013; nil and 34,349,894 shares issued and outstanding as of december 31, 2014 and 2013
    		                                                
      series b convertible preferred stock, par value of 0.001 per share—nil and 27,081,680 shares authorized, issued and outstanding as of december 31, 2014 and 2013
    		                                                
      stockholders’ equity
    		                                                
      preferred stock, par value of 0.001 per share—25,000,000 shares authorized; nil outstanding as of december 31, 2014 and 2013
    		                                                
      total liabilities, convertible preferred stock and stockholders’ equity
    		                                           197,967,000 210,931,000 162,586,000 172,707,000  
      series a redeemable convertible preferred stock, par value of 0.001 per share—nil and 35,377,556 shares authorized; nil and 34,349,894 shares issued and outstanding as of september 30, 2014 and december 31, 2013
    		                                                
      series b convertible preferred stock, par value of 0.001 per share—nil and 27,081,680 shares authorized, issued and outstanding as of september 30, 2014 and december 31, 2013
    		                                                
      preferred stock, par value of 0.001 per share—25,000,000 shares authorized; nil outstanding as of september 30, 2014 and december 31, 2013
    		                                                
      series a redeemable convertible preferred stock, par value of 0.001 per share—nil and 35,377,566 shares authorized; nil and 34,349,894 shares issued and outstanding as of june 30, 2014 and december 31, 2013
    		                                                
      series b convertible preferred stock, par value of 0.001 per share—nil and 27,081,680 shares authorized, issued and outstanding as of june 30, 2014 and december 31, 2013
    		                                                
      preferred stock, par value of 0.001 per share—25,000,000 shares authorized; nil outstanding as of june 30, 2014 and december 31, 2013
    		                                                
      series a redeemable convertible preferred stock, par value of 0.001 per share—nil and 35,377,566 shares authorized; nil and 34,349,894 shares issued and outstanding as of march 31, 2014 and december 31, 2013
    		                                                
      series b convertible preferred stock, par value of 0.001 per share—nil and 27,081,680 shares authorized, issued and outstanding as of march 31, 2014 and december 31, 2013
    		                                                
      preferred stock, par value of 0.001 per share—25,000,000 shares authorized; nil outstanding as of march 31, 2014 and december 31, 2013
    		                                                
      deficit accumulated during the development stage
    		                                              -92,869,000 -74,836,000 
      liabilities, convertible preferred stock and stockholders’ deficit
    		                                                
      series a redeemable convertible preferred stock, par value of 0.001 per share—35,377,556
    		                                                
      shares authorized as of december 31, 2012 and 2013; 34,349,894 shares issued and outstanding as of december 31, 2012 and 2013; redemption value of 138,155 as of december 31, 2013
    		                                               51,001,000 
      series b convertible preferred stock, par value of 0.001 per share—27,081,680 shares
    		                                                
      authorized, issued and outstanding as of december 31, 2012 and 2013; aggregate liquidation preference of 76,739 as of december 31, 2013
    		                                               73,929,000 
      stockholders’ deficit:
    		                                                
      and 3,766,289 shares issued and outstanding as of december 31, 2012 and 2013
    		                                               4,000 
      total stockholders’ deficit
    		                                               -74,821,000 
      total liabilities, convertible preferred stock and stockholders’ deficit
    		                                               59,649,000 
      operating expenses:
    		                                                
      research and development
    		                                               12,641,000 
      general and administrative
    		                                               3,344,000 
      total operating expenses
    		                                               15,985,000 
      income from operations
    		                                               -15,985,000 
      other income, net:
    		                                                
      interest income
    		                                               1,000 
      interest expense
    		                                                
      other income
    		                                               -350,000 
      total other income
    		                                               -349,000 
      net income
    		                                               -16,334,000 
      net income attributable to common stockholders
    		                                               -19,561,000 
      net income per share
    		                                                
      diluted
    		                                               -14,200 
      shares used in computing net income per share attributable to common stockholders, basic and diluted
    		                                               1,377,207,000 
    The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.