7Baggers

PTC Therapeutics, Inc
(NASDAQ:PTCT) 

PTCT stock logo

PTC Therapeutics, Inc., a biopharmaceutical company, focuses on the discovery, development, and commercialization of medicines for the treatment of rare disorders. The company offers Translarna (ataluren) and Emflaza (deflazacort) for the treatment of nonsense mutation Duchenne muscular dystrophy in...

Founded: 1998
Full Time Employees: 754
Sector: Healthcare
Industry: Biotechnology
Pharmaceuticals
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Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-09-30 2015-06-30 2015-03-31 2014-09-30 2014-06-30 2014-03-31 2013-09-30 2013-06-30 
                                                     
      revenues:
    		                                                 
      net product revenue
    		225,573,000 183,992,000 130,956,000 118,329,000 153,426,000 154,706,000 135,421,000 133,220,000 177,604,000 155,062,000 144,038,000 174,592,000 187,557,000 127,508,000 134,186,000 143,701,000 129,832,000 118,906,000 115,605,000 103,113,000 91,280,000 107,258,000 82,708,000 75,239,000 68,196,000 81,407,000 71,369,000 85,476,000 53,054,000 85,833,000 53,021,000 68,170,000 55,981,000 57,953,000 41,780,000 47,891,000 26,442,000 25,119,000 22,013,000 15,437,000 18,878,000 9,772,000 6,161,000 5,069,000      
      collaboration and license revenue
    		143,000 -73,000 9,258,000 2,941,000 986,231,000                                             
      royalty revenue
    		46,835,000 79,387,000 70,793,000 57,605,000 36,439,000 58,162,000 61,365,000 53,183,000 31,154,000 50,999,000 50,173,000 36,853,000 30,831,000 39,876,000 32,924,000 21,825,000 18,896,000 21,295,000 13,127,000 13,563,000 6,655,000 4,090,000 696,000                           
      total revenues
    		272,551,000 164,677,000 211,007,000 178,875,000 1,176,096,000 213,172,000 196,786,000 186,704,000 210,118,000 307,056,000 196,576,000 213,808,000 220,382,000 167,412,000 217,127,000 165,526,000 148,735,000 165,229,000 138,743,000 116,676,000 117,942,000 118,864,000 118,404,000 75,239,000 68,259,000 96,459,000 71,416,000 85,522,000 53,583,000 86,338,000 53,591,000 68,743,000 56,062,000 78,030,000 41,853,000 47,962,000 26,547,000 25,191,000 22,986,000 15,633,000 18,895,000 9,776,000 6,774,000 7,482,000 1,694,000 1,677,000 9,217,000   
      yoy
    		-76.83% -22.75% 7.23% -4.19% 459.73% -30.58% 0.11% -12.68% -4.66% 83.41% -9.46% 29.17% 48.17% 1.32% 56.50% 41.87% 26.11% 39.01% 17.18% 55.07% 72.79% 23.23% 65.79% -12.02% 27.39% 11.72% 33.26% 24.41% -4.42% 10.65% 28.05% 43.33% 111.18% 209.75% 82.08% 206.80% 40.50% 157.68% 239.33% 108.94% 1015.41% 482.95% -26.51%       
      qoq
    		65.51% -21.96% 17.96% -84.79% 451.71% 8.33% 5.40% -11.14% -31.57% 56.20% -8.06% -2.98% 31.64% -22.90% 31.17% 11.29% -9.98% 19.09% 18.91% -1.07% -0.78% 0.39% 57.37% 10.23% -29.24% 35.07% -16.49% 59.61% -37.94% 61.11% -22.04% 22.62% -28.15% 86.44% -12.74% 80.67% 5.38% 9.59% 47.04% -17.26% 93.28% 44.32% -9.46% 341.68% 1.01% -81.81%    
      operating expenses:
    		                                                 
      cost of product, collaboration and license sales, excluding amortization of acquired intangible assets
    		28,028,000 6,950,000 15,781,000 11,420,000 12,862,000                                             
      amortization of acquired intangible assets
    		11,581,000 9,349,000 7,534,000 4,061,000 3,798,000 3,307,000 3,036,000 2,865,000 51,530,000 77,174,000 58,649,000 47,397,000 39,415,000 35,764,000 31,023,000 26,294,000 23,473,000 16,340,000 14,383,000 12,751,000 11,278,000 10,583,000 9,630,000 8,731,000 7,949,000 4,919,250 7,025,000 6,575,000                      
      research and development
    		100,873,000 133,128,000 100,158,000 112,990,000 108,973,000 124,770,000 161,412,000 132,169,000 116,129,000 121,353,000 164,212,000 185,874,000 195,124,000 188,694,000 165,462,000 157,263,000 140,078,000 149,844,000 130,845,000 125,482,000 134,513,000 118,013,000 92,998,000 176,525,000 90,107,000 81,831,000 63,076,000 59,979,000 52,566,000 53,647,000 54,368,000 32,607,000 31,363,000 29,234,000 30,024,000 30,835,000 27,363,000 26,011,000 31,396,000 28,827,000 31,399,000 30,640,000 28,190,000 27,938,000 18,765,000 18,313,000 15,889,000 13,886,196 14,712,091 
      selling, general and administrative
    		86,183,000 96,874,000 84,046,000 85,262,000 80,961,000 84,683,000 73,456,000 69,500,000 73,272,000 76,291,000 80,886,000 88,449,000 86,914,000 92,718,000 80,118,000 79,892,000 73,271,000 86,548,000 69,252,000 68,878,000 61,095,000 75,456,000 57,840,000 53,659,000 58,209,000 63,497,000 49,284,000 49,215,000 40,544,000 48,666,000 38,368,000 33,545,000 32,969,000 35,483,000 31,423,000 28,866,000 25,500,000 24,172,000 23,654,000 23,366,000 25,938,000 21,368,000 17,210,000 17,615,000      
      change in the fair value of contingent consideration
    		    -800,000 -10,175,000 700,000 5,100,000 -100,000 -2,700,000 1,500,000 -128,900,000                                      
      tangible asset impairment and losses on transactions
    		927,000 -10,275,000 472,000 99,000 77,000 -2,855,000 1,844,000 1,761,000                                          
      total operating expenses
    		227,592,000 236,026,000 207,991,000 213,832,000 205,871,000 375,561,000 251,296,000 226,922,000 255,571,000 301,236,000 314,740,000 423,351,000 337,997,000 367,753,000 285,314,000 257,888,000 235,257,000 249,959,000 231,819,000 215,169,000 216,090,000 215,238,000 173,535,000 262,512,000 161,250,000 169,243,000 131,891,000 124,280,000 122,723,000 131,476,000 101,821,000 74,317,000 72,805,000 72,580,000 72,745,000 60,459,000 52,902,000 50,183,000 55,050,000 52,193,000 57,337,000 52,008,000 45,400,000 45,553,000 29,295,000 27,046,000 23,429,000 20,565,188 21,307,148 
      income from operations
    		44,959,000 -71,349,000 3,016,000 -34,957,000 970,225,000 -162,389,000 -54,510,000 -40,218,000 -45,453,000 5,820,000 -118,164,000 -209,543,000 -117,615,000 -200,341,000 -68,187,000 -92,362,000 -86,522,000 -84,730,000 -93,076,000 -98,493,000 -98,148,000 -96,374,000 -55,131,000 -187,273,000 -92,991,000 -72,784,000 -60,475,000 -38,758,000 -69,140,000 -45,138,000 -48,230,000 -5,574,000 -16,743,000 5,450,000 -30,892,000 -12,497,000 -26,355,000 -24,992,000 -32,064,000           
      yoy
    		-95.37% -56.06% -105.53% -13.08% -2234.57% -2890.19% -53.87% -80.81% -61.35% -102.91% 73.29% 126.87% 35.94% 136.45% -26.74% -6.22% -11.85% -12.08% 68.83% -47.41% 5.55% 32.41% -8.84% 383.19% 34.50% 61.25% 25.39% 595.34% 312.95% -928.22% 56.12% -55.40% -36.47% -121.81% -3.66%               
      qoq
    		-163.01% -2465.68% -108.63% -103.60% -697.47% 197.91% 35.54% -11.52% -880.98% -104.93% -43.61% 78.16% -41.29% 193.81% -26.17% 6.75% 2.11% -8.97% -5.50% 0.35% 1.84% 74.81% -70.56% 101.39% 27.76% 20.35% 56.03% -43.94% 53.17% -6.41% 765.27% -66.71% -407.21% -117.64% 147.20% -52.58% 5.45% -22.06%            
      operating margin %
    		16.50% -43.33% 1.43% -19.54% 82.50% -76.18% -27.70% -21.54% -21.63% 1.90% -60.11% -98.01% -53.37% -119.67% -31.40% -55.80% -58.17% -51.28% -67.09% -84.42% -83.22% -81.08% -46.56% -248.90% -136.23% -75.46% -84.68% -45.32% -129.03% -52.28% -90.00% -8.11% -29.87% 6.98% -73.81% -26.06% -99.28% -99.21% -139.49% 0% 0% 0% 0% 0% 0% 0% 0% NaN% NaN% 
      interest expense
    		-49,030,000 -55,188,000 -32,592,000 -30,358,000 -34,092,000 -41,060,000 -41,609,000 -43,490,000 -40,834,000 -44,275,000 -28,160,000 -29,415,000 -27,331,000 -24,500,000 -20,880,000 -21,976,000 -23,514,000 -22,502,000 -21,802,000 -22,559,000 -19,159,000 -24,292,000 -21,039,000 -5,379,000 -5,642,000 -5,463,000 -2,666,000 -2,074,000 -2,288,000 -3,248,000 -3,118,000 -2,884,000 -3,303,000 -3,446,000 -3,421,000 -3,008,000 -2,219,000             
      other income
    		1,609,000 -12,546,000 6,502,000  -6,305,000   -2,025,000 1,591,000   1,479,000 9,956,000   -34,357,000  -31,376,000 -18,782,000 3,170,000  58,946,000 28,766,000 11,309,000  11,214,000 2,800,000 -183,000 -109,000 -937,000 734,000 -673,000 1,004,000 -343,250 766,000           17,000    
      income before income tax expense
    		-2,462,000    929,828,000                                             
      income tax expense
    		-347,000    -63,266,000    -6,880,000    -3,969,000   -3,392,000 -4,835,000   -488,000 -451,000   -84,000 -222,000   -774,000 -576,000 -241,000 -355,000 -389,000 -221,000 -828,000 -191,000  -165,000 -51,500 -184,000           
      net income attributable to common stockholders
    		-2,809,000 -134,965,000 15,896,000 -64,849,000 866,562,000                                           -4,416,499 -14,586,578 
      yoy
    		-100.32%                                                 
      qoq
    		-97.92% -949.05% -124.51% -107.48%                                            -69.72%  
      net income margin %
    		-1.03% -81.96% 7.53% -36.25% 73.68% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% -Infinity% -Infinity% 
      weighted-average shares outstanding:
    		                                                 
      basic
    		82,521,023,000 79,534,290,000 78,471,119,000 78,151,240,000 78,115,836,000                                           23,803,282 2,648,832 
      diluted
    		82,521,023,000 88,311,494,000 87,115,369,000 78,151,240,000 86,385,922,000                                             
      net income per share
    		-0.03 -1.82 0.2 -0.83 11.09 -0.85 -1.39 -1.29 -1.2 -2.06 -1.76 -2.66 -1.88 -2.36 -1.53 -2.13 -1.78 -2.02 -1.89 -1.68 -1.83 -1.05 -1.03 -2.78 -1.81 -1.26 -1.06 -0.75 -1.29 -0.99 -1.06 -0.21 -0.46 0.07 -0.82 -0.44 -0.85 -0.78 -1.03 -1.14 -1.22 -1.27 -1.14 -1.15 -0.93 -0.86 -0.58 -0.19 -5.51 
      manufacturing revenue
    		       301,000 1,360,000 971,000 2,365,000 2,363,000 1,988,000                                     
      income before income tax benefit
    		 -139,083,000 -23,074,000 -71,052,000                                              
      income tax benefit
    		 4,118,000 38,970,000 6,203,000  28,813,000 -8,663,000 -13,446,000  1,259,000 33,620,000 38,596,000  18,804,000 17,893,000   -226,000 36,000   -12,634,000 -22,288,000   -10,644,000 344,000         -150,000    93,000          
      other expense
    		   -5,737,000  -576,500 -1,872,000   -2,208,000 -20,266,000   -21,088,750 -38,141,000  -11,855,000    -10,884,000    -13,832,000           -1,820,000 -318,000 686,000 -786,000           
      collaboration revenue
    		         100,024,000   6,000 28,000 50,017,000  7,000 25,028,000 10,011,000  20,007,000                     2,000 207,000 338,000 716,000 1,418,000 9,147,000 15,455,361 5,867,806 
      cost of product sales, excluding amortization of acquired intangible assets
    		     16,283,000 10,848,000 15,527,000 14,740,000 29,118,000 9,493,000 12,731,000 14,144,000 10,893,000 14,011,000 9,639,000 10,135,000 9,327,000 6,539,000 7,358,000 9,104,000 4,886,000 4,667,000 5,304,000 4,085,000 2,148,250 3,006,000 3,211,000                      
      intangible asset impairment
    		           217,800,000                                      
      loss before income tax benefit
    		     -94,699,000 -97,991,000 -85,733,000  -157,051,000 -166,590,000 -237,479,000                                      
      net loss attributable to common stockholders
    		     -65,886,000 -106,654,000 -99,179,000 -91,576,000 -155,792,000 -132,970,000 -198,883,000 -138,959,000 -170,889,000 -109,315,000 -152,087,000 -126,726,000 -143,265,000 -133,624,000 -118,370,000 -128,642,000 -74,354,000 -69,692,000 -181,427,000 -112,687,000 -77,677,000 -59,997,000 -41,789,000 -72,113,000 -48,330,000 -50,969,000 -9,520,000 -19,263,000 1,270,000 -33,738,000 -17,475,000 -29,057,000 -26,796,000 -35,167,000 -38,914,000 -41,233,000    -27,282,000 -25,104,000 -14,098,000   
      weighted-average shares outstanding:
    		                                                 
      basic and diluted
    		     76,845,055,000 76,925,523,000 76,725,070,000 76,496,127,000 74,838,392,000 75,377,997,000 74,730,433,000 73,729,284,000 71,728,634,000 71,654,671,000 71,372,940,000 71,215,105,000 70,466,393,000 70,585,938,000 70,414,632,000 70,188,602,000 66,027,908,000 67,641,171,000 65,150,780,000 62,389,158,000 58,863,185,000 56,463,528,000 55,912,748,000 55,855,111,000 46,576,313,000 48,096,521,000 46,137,833,000 41,626,617,000 39,183,073,000 41,296,740,000 39,621,738,000 34,305,948,000 34,044,584,000 34,088,741,000 34,000,333,000 33,919,169,000 33,908,853,000 33,600,653,000 33,067,752,000 29,351,693,000 29,332,227,000 24,492,487,000   
      loss before income tax expense
    		        -84,696,000    -134,990,000 -189,693,000 -127,208,000 -148,695,000 -121,891,000 -138,608,000 -133,660,000 -117,882,000 -128,191,000 -61,720,000 -47,404,000 -181,343,000 -112,465,000 -67,033,000 -60,341,000 -41,015,000 -71,537,000 -49,323,000 -50,614,000 -9,131,000 -19,042,000 2,098,000 -33,547,000 -17,325,000 -28,892,000 -28,777,000 -34,983,000           
      change in the fair value of deferred and contingent consideration
    		            2,400,000 6,300,000 -5,300,000 -15,200,000 -11,700,000 -12,100,000 10,800,000 700,000 100,000 6,300,000 8,400,000 7,680,000 900,000 12,400,000 9,500,000 5,300,000 21,160,000                     
      settlement of deferred and contingent consideration
    		                       10,613,000                          
      collaboration and grant revenue
    		                     8,765,750 35,000,000  63,000 15,052,000 47,000 46,000 529,000 505,000 570,000 573,000 81,000 20,077,000 73,000 71,000 105,000 72,000 973,000 196,000 17,000         
      cost of product sales, excluding amortization of acquired intangible asset
    		                            2,376,000 3,761,000 3,292,000 2,572,000 3,045,000 2,435,000 1,582,000               
      amortization of acquired intangible asset
    		                            6,077,000 6,062,000 5,793,000 5,593,000 5,428,000 5,428,000 9,716,000               
      cost of product sales
    		                                   758,000 39,000             
      interest income
    		                                     -2,127,000 -2,133,000    498,000 524,000 354,000 248,000 171,000 26,695  
      grant revenue
    		                                         2,000 406,000 2,075,000 897,000 259,000 70,000 834,212 986,406 
      net income
    		                                         -43,223,000 -38,361,000 -37,915,000      
      net product sales
    		                                            81,000     
      general and administrative
    		                                            10,530,000 8,733,000 7,540,000 6,678,992 6,595,057 
      loss on extinguishment of debt
    		                                                 
      deemed dividend
    		                                                 
      gain on exchange of convertible preferred stock in connection with recapitalization
    		                                                 
      total revenues and non-cash cancellation revenue
    		                                               16,289,573 6,854,212 
      less beneficial conversion charge
    		                                                 
      weighted-average shares outstanding:
    		                                                 
      basic
    		82,521,023,000 79,534,290,000 78,471,119,000 78,151,240,000 78,115,836,000                                           23,803,282 2,648,832 
      diluted
    		                                               23,803,282 2,648,832 
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-09-30 2015-06-30 2015-03-31 2014-09-30 2014-06-30 2014-03-31 2013-09-30 2013-06-30 
                                                       
        assets
      		                                                 
        current assets:
      		                                                 
        cash and cash equivalents
      		833,986,000 984,648,000 672,617,000 1,017,386,000 1,480,231,000 779,709,000 526,001,000 654,779,000 548,355,000 594,001,000 165,157,000 208,393,000 167,495,000 279,834,000 104,424,000 158,158,000 144,178,000 189,718,000 189,818,000 177,347,000 146,632,000 208,812,000 433,970,000 158,461,000 123,287,000 288,028,000 523,577,000 136,094,000 201,144,000 169,498,000 206,913,000 223,788,000 97,675,000 111,792,000 141,838,000 133,011,000 54,106,000 58,321,000 50,286,000 35,658,000 40,165,000 140,712,000 29,220,000 36,825,000 52,873,000 21,172,000 115,855,000 24,044,819 154,095,269 
        marketable securities
      		1,058,477,000 960,723,000 1,015,200,000 971,764,000 546,950,000 359,987,000 487,356,000 438,514,000 336,458,000 282,738,000 129,653,000 129,550,000 118,808,000 130,871,000 184,008,000 347,387,000 443,615,000 583,658,000 678,125,000 769,734,000 841,774,000 894,838,000 707,049,000 340,430,000 472,572,000 398,535,000 185,072,000 227,447,000 206,018,000 58,088,000 42,491,000 72,318,000 80,595,000 79,454,000 27,472,000 48,058,000 148,471,000 173,345,000 198,052,000 237,235,000 258,547,000 230,809,000 225,999,000 243,642,000 156,516,000 205,687,000 130,730,000 133,182,565 11,582,786 
        trade and royalty receivables
      		219,919,000 181,621,000 203,074,000 196,133,000 210,495,000 158,554,000 199,976,000 187,150,000 197,660,000 160,822,000 165,718,000 177,503,000 201,867,000 155,614,000 124,456,000 135,943,000 141,288,000 110,455,000                                
        inventory
      		75,567,000 79,647,000 52,688,000 34,061,000 21,675,000 23,194,000 35,671,000 31,826,000 30,058,000 30,577,000 35,752,000 32,018,000 26,649,000 21,808,000 14,812,000 15,004,000 15,281,000 15,856,000 15,613,000 16,441,000 16,234,000 18,697,000 19,481,000 18,373,000 19,133,000 19,285,000 17,107,000 16,897,000 16,219,000 16,117,000 13,660,000 13,852,000 12,355,000 10,754,000 7,792,000 6,912,000 1,354,000             
        prepaid expenses and other current assets
      		66,054,000 67,309,000 64,224,000 53,531,000 57,055,000 44,087,000 32,546,000 45,641,000 56,207,000 150,491,000 44,082,000 42,227,000 98,573,000 105,658,000 89,562,000 38,184,000 29,647,000 54,681,000 30,939,000 23,910,000 23,601,000 39,469,000 26,888,000 34,116,000 24,307,000 17,898,000 20,723,000 17,424,000 9,348,000 9,247,000 8,020,000 6,305,000 5,760,000 6,669,000 5,413,000 5,224,000 4,623,000 4,691,000 4,860,000 4,776,000 5,104,000 4,627,000 4,241,000 6,116,000 2,831,000 2,597,000 1,957,000 2,126,575 1,609,382 
        total current assets
      		2,254,003,000 2,273,948,000 2,007,803,000 2,272,875,000 2,316,406,000 1,365,531,000 1,281,550,000 1,357,910,000 1,168,738,000 1,218,629,000 540,362,000 589,691,000 613,392,000 693,785,000 517,262,000 694,676,000 774,009,000 954,368,000 1,011,140,000 1,066,233,000 1,122,365,000 1,231,745,000 1,244,174,000 605,024,000 691,922,000 779,284,000 806,862,000 474,966,000 479,079,000 320,857,000 313,281,000 375,646,000 241,996,000 249,063,000 221,259,000 226,972,000 240,727,000 261,286,000 280,607,000 297,434,000 326,434,000 384,164,000 264,574,000 289,761,000 213,516,000 230,314,000 249,380,000 160,137,810 168,158,078 
        fixed assets
      		52,739,000 55,371,000 56,970,000 57,189,000 59,459,000 60,970,000 63,175,000 65,987,000 92,779,000 87,089,000 85,031,000 82,129,000 79,492,000 72,590,000 66,889,000 64,913,000 59,088,000 52,585,000 46,354,000 42,910,000 37,123,000 33,831,000 28,141,000 26,806,000 26,169,000 21,549,000 18,484,000 15,391,000 14,540,000 12,694,000 8,805,000 8,217,000 8,302,000 8,376,000 6,882,000 6,839,000 7,059,000 7,429,000 7,059,000 7,601,000 8,426,000 8,799,000 9,017,000 9,408,000 6,193,000 6,417,000 6,328,000 6,942,956 7,153,532 
        intangible assets
      		380,684,000 388,753,000 396,466,000 143,806,000 118,448,000 118,794,000 330,368,000 329,879,000 330,040,000 379,497,000 423,342,000 451,629,000 686,205,000 705,891,000 749,890,000 760,154,000 763,665,000 724,841,000 723,260,000 717,079,000 712,574,000 715,328,000 712,536,000 708,814,000 705,294,000 710,500,000 702,910,000 702,729,000 694,955,000 701,031,000 604,612,000 126,290,000 127,565,000 132,993,000 138,422,000 148,138,000              
        goodwill
      		82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 82,341,000 100,309,000                   
        operating lease rou assets
      		76,692,000 80,053,000 80,682,000 56,162,000 57,317,000 56,685,000 59,465,000 57,135,000 91,186,000 91,896,000 94,072,000 96,686,000 99,531,000 102,430,000 104,901,000 141,635,000 76,093,000 77,421,000 78,699,000 80,694,000 82,382,000 84,410,000 85,810,000                           
        deposits and other assets
      		22,645,000 18,301,000 19,438,000 21,782,000 21,416,000 20,703,000 25,337,000 23,103,000 24,545,000 36,246,000 34,737,000 35,648,000 47,878,000 48,582,000 55,115,000 60,338,000 44,395,000 46,500,000 65,531,000 69,412,000 75,156,000 60,623,000 28,057,000 53,652,000 39,866,000 30,108,000 30,889,000 16,145,000 12,996,000 2,299,000 1,620,000 1,620,000 1,548,000 1,221,000 1,157,000 1,129,000 859,000 630,000 511,000 528,000 372,000 3,137,000 231,000 351,000 1,086,000 827,000 132,000 163,349 156,474 
        total assets
      		2,869,104,000 2,898,767,000 2,643,700,000 2,634,155,000 2,655,387,000 1,705,024,000 1,842,236,000 1,916,355,000 1,789,629,000 1,895,698,000 1,259,885,000 1,338,124,000 1,608,839,000 1,705,619,000 1,576,398,000 1,804,057,000 1,799,591,000 1,938,056,000 2,007,325,000 2,058,669,000 2,111,941,000 2,208,278,000 2,181,059,000 1,476,637,000 1,545,592,000 1,623,782,000 1,641,486,000 1,291,572,000 1,283,911,000 1,119,222,000 1,028,627,000 511,773,000 379,411,000 391,653,000 367,720,000 383,078,000 248,645,000 269,345,000 288,177,000 305,563,000 335,232,000 396,100,000 273,822,000 299,520,000 220,795,000 237,558,000 255,840,000 167,244,115 175,468,084 
        liabilities and stockholders’ deficit
      		                                                 
        current liabilities:
      		                                                 
        accounts payable and accrued expenses
      		313,050,000 381,272,000 303,141,000 338,945,000 317,807,000 304,292,000 336,346,000 338,800,000 330,924,000 391,983,000 370,731,000 358,562,000 332,091,000 320,366,000 329,322,000 330,918,000 246,521,000 288,784,000 252,329,000 235,921,000 205,636,000 242,168,000 218,561,000 164,376,000 145,386,000 159,276,000 128,150,000 122,375,000 98,450,000 128,199,000 102,788,000 82,534,000 71,437,000 76,446,000 64,054,000 63,996,000 45,153,000 48,759,000 47,759,000 42,183,000 43,493,000 31,695,000 23,082,000 23,532,000 16,493,000 11,341,000 8,735,000 10,205,493 10,058,471 
        current portion of long-term debt
      		286,937,000 286,631,000 286,319,000             149,908,000 149,721,000 149,540,000 149,358,000     18,333,000 20,000,000 20,000,000 20,000,000 20,000,000 16,667,000 11,667,000 6,667,000 1,666,000               12,000 84,234 2,746,512 
        deferred revenue
      		498,000 2,040,000 1,691,000 9,760,000 12,833,000 5,505,000    801,000 1,224,000  214,000 1,351,000       1,887,000 4,151,000 5,992,000 7,702,000 8,638,000 8,242,000 8,810,000 8,005,000 5,497,000 3,716,000 2,004,000   3,937,000 6,122,000 2,602,000   910,000 726,000 396,000   373,000 769,000 242,000 492,000 3,631,430 6,983,506 
        operating lease liabilities- current
      		12,078,000 12,484,000 11,810,000 11,725,000 11,464,000 10,363,000 14,113,000 13,714,000 14,572,000 13,002,000 11,703,000 10,199,000 9,598,000 9,370,000 8,895,000 8,898,000 7,369,000 7,273,000 7,144,000 7,335,000 7,333,000 7,465,000 5,859,000                           
        finance lease liabilities- current
      		6,000,000 3,000,000 2,676,000 5,358,000 5,047,000 3,000,000 2,642,000 2,292,000 1,948,000 3,000,000 2,611,000 2,230,000 1,857,000 3,000,000 2,583,000 2,174,000 1,772,000 3,000,000 2,557,000 2,121,000 1,694,000 1,276,000 1,251,000 4,180,000                          
        liability for sale of future royalties- current
      		305,041,000 283,000,000 260,608,000 262,021,000 248,240,000 257,821,000 257,611,000 254,997,000 227,102,000 194,314,000 105,849,000 105,351,000 97,874,000 72,149,000 77,964,000 74,022,000 69,943,000 59,291,000 52,651,000 44,335,000 33,149,000 21,023,000 22,159,000                           
        total current liabilities
      		923,604,000 968,427,000 866,245,000 627,809,000 595,391,000 580,981,000 610,712,000 609,803,000 574,546,000 603,100,000 492,118,000 476,342,000 441,634,000 406,236,000 420,076,000 567,371,000 476,776,000 509,348,000 465,261,000 290,962,000 250,949,000 277,333,000 253,822,000 201,843,000 217,668,000 235,857,000 183,500,000 173,959,000 143,046,000 166,796,000 114,922,000 86,474,000 72,716,000 82,048,000 71,899,000 67,985,000 45,418,000 49,624,000 48,926,000 42,909,000 43,889,000 31,695,000 23,082,000 23,905,000 17,262,000 11,583,000 9,239,000 13,921,157 19,788,489 
        operating lease liabilities- noncurrent
      		90,072,000 93,583,000 95,488,000 71,237,000 73,559,000 74,947,000 82,770,000 79,118,000 104,837,000 97,627,000 99,682,000 100,425,000 100,442,000 100,860,000 102,124,000 137,353,000 72,432,000 73,619,000 74,823,000 76,425,000 77,863,000 79,499,000 81,674,000                           
        finance lease liabilities- noncurrent
      		 3,000,000 13,833,000 13,833,000 13,833,000 15,574,000 15,574,000 15,574,000 15,574,000 17,184,000 17,184,000 17,184,000 17,184,000 18,675,000 18,675,000 18,675,000 18,675,000 20,053,000 20,053,000 20,053,000 20,053,000 23,053,000 22,608,000 22,031,000                          
        liability for sale of future royalties- noncurrent
      		2,022,189,000 2,025,366,000 1,821,313,000 1,833,985,000 1,850,223,000 1,823,955,000 1,824,440,000 1,829,883,000 1,611,831,000 1,619,783,000 657,469,000 661,229,000 665,677,000 685,737,000 680,182,000 680,306,000 674,803,000 674,694,000 670,549,000 664,829,000 661,835,000 658,739,000 642,099,000                           
        other long-term liabilities
      		13,704,000 13,704,000 2,579,000 7,824,000 22,429,000 21,426,000 77,000 141,000 141,000 141,000 141,000 141,000 141,000 2,641,000 4,686,000    1,376,000 1,392,000 1,392,000 1,392,000 1,968,000 26,678,000 14,786,000 9,159,000 9,455,000 8,416,000 8,770,000 58,000 101,000 153,000 209,000 243,000 269,000 292,000 311,000 335,000 2,515,000 2,094,000 1,976,000 2,056,000 2,159,000 2,295,000 2,237,000 2,219,000 2,259,000 2,290,445 2,518,288 
        total liabilities
      		3,049,569,000 3,104,080,000 2,799,458,000 2,840,701,000 2,841,147,000 2,803,095,000 2,896,588,000 2,896,536,000 2,683,545,000 2,714,253,000 1,930,695,000 1,917,392,000 2,066,400,000 2,052,705,000 1,803,302,000 1,986,275,000 1,890,172,000 1,936,618,000 1,902,399,000 1,862,092,000 1,819,365,000 1,726,296,000 1,670,105,000 904,143,000 1,016,858,000 1,029,452,000 977,832,000 802,887,000 770,969,000 768,495,000 642,537,000 244,371,000 229,103,000 235,216,000 221,838,000 213,347,000 147,818,000 149,762,000 148,000,000 139,939,000 139,231,000 126,949,000 25,241,000 26,200,000 19,499,000 13,802,000 11,498,000 16,211,602 22,548,444 
        stockholders’ deficit:
      		                                                 
        common stock
      		81,000 80,000 79,000 78,000 78,000 77,000 76,000 76,000 76,000 75,000 75,000 75,000 73,000 72,000 71,000 71,000 71,000 71,000 70,000 70,000 70,000 70,000 68,000 67,000 62,000 62,000 61,000 58,000 58,000 51,000 51,000 47,000 42,000 42,000 41,000 41,000 34,000 34,000 34,000 34,000 34,000 34,000 34,000 33,000 30,000 30,000 30,000 24,344 24,344 
        additional paid-in capital
      		2,778,026,000 2,748,335,000 2,667,497,000 2,631,180,000 2,608,422,000 2,574,611,000 2,530,902,000 2,510,574,000 2,486,722,000 2,466,233,000 2,447,292,000 2,416,904,000 2,339,886,000 2,305,020,000 2,222,905,000 2,184,230,000 2,152,639,000 2,123,606,000 2,092,534,000 2,063,687,000 2,033,972,000 2,171,746,000 2,101,136,000 2,067,274,000 1,834,061,000 1,795,351,000 1,775,799,000 1,539,530,000 1,523,115,000 1,288,137,000 1,275,004,000 1,105,124,000 975,418,000 966,534,000 958,206,000 949,331,000 865,834,000 856,142,000 847,700,000 837,850,000 829,114,000 812,294,000 747,869,000 734,489,000 596,617,000 591,636,000 587,128,000 461,960,966 459,391,899 
        accumulated other comprehensive income
      		8,466,000 10,501,000 5,930,000 7,356,000      -1,285,000 9,609,000 -1,431,000 -1,587,000 4,796,000 36,205,000      -38,743,000 -60,957,000 -35,727,000 -10,016,000 -1,985,000 -10,584,000 616,000 1,922,000 805,000 1,462,000 1,628,000 1,855,000 4,953,000 3,969,000 3,013,000 1,999,000   756,000 885,000 1,084,000     90,000    
        accumulated deficit
      		-2,967,038,000 -2,964,229,000 -2,829,264,000 -2,845,160,000 -2,780,311,000 -3,646,873,000 -3,580,987,000 -3,474,333,000 -3,375,154,000 -3,283,578,000 -3,127,786,000 -2,994,816,000 -2,795,933,000 -2,656,974,000 -2,486,085,000 -2,376,770,000 -2,224,683,000 -2,097,957,000 -1,954,717,000 -1,821,093,000 -1,702,723,000 -1,628,877,000 -1,554,523,000 -1,484,831,000 -1,303,404,000 -1,190,499,000 -1,112,822,000 -1,052,825,000 -1,011,036,000 -938,923,000 -890,593,000 -839,624,000 -830,105,000 -814,108,000 -815,378,000 -781,640,000 -764,165,000 -735,108,000 -708,313,000           
        total stockholders’ deficit
      		-180,465,000 -205,313,000 -155,758,000 -206,546,000 -185,760,000 -1,098,071,000 -1,054,352,000 -980,181,000 -893,916,000 -818,555,000 -670,810,000 -579,268,000 -457,561,000                                     
        total liabilities and stockholders’ deficit
      		2,869,104,000 2,898,767,000 2,643,700,000 2,634,155,000 2,655,387,000 1,705,024,000 1,842,236,000 1,916,355,000 1,789,629,000 1,895,698,000 1,259,885,000 1,338,124,000 1,608,839,000                                     
        long-term debt
      		   286,013,000 285,712,000 285,412,000 285,106,000 284,806,000 284,512,000 284,213,000 573,174,000 572,643,000 572,091,000 571,722,000 282,749,000 282,460,000 282,176,000 281,894,000 281,604,000 430,496,000 430,038,000 309,145,000 302,971,000 297,029,000 294,574,000 293,859,000 293,149,000 135,683,000 138,468,000 141,347,000 144,258,000 147,204,000 146,878,000 144,971,000 143,091,000 141,242,000 99,895,000 98,216,000 96,559,000 94,936,000 93,366,000 93,198,000        
        contingent consideration payable
      		     800,000 22,000,000 21,300,000 36,200,000 36,300,000 39,000,000 37,500,000 166,400,000 164,000,000 157,700,000 163,000,000 228,200,000 239,900,000 252,000,000 241,200,000 240,500,000 240,400,000 234,100,000 225,700,000 357,200,000 356,300,000 344,900,000 336,200,000 330,900,000 310,240,000 218,700,000                   
        accumulated other comprehensive loss
      		    -13,949,000 -25,886,000 -4,343,000 -16,498,000 -5,560,000       10,251,000 -18,608,000 -24,282,000 -32,961,000 -46,087,000                 -876,000 -1,485,000         80,000   
        deferred tax liability
      		      55,909,000 55,911,000 55,904,000 55,905,000 51,927,000 51,928,000 102,831,000 102,834,000 137,110,000 137,110,000 137,110,000 137,110,000 136,733,000 136,735,000 136,735,000 136,735,000 130,863,000 130,862,000 130,862,000 130,862,000 122,032,000 122,032,000 122,032,000 122,032,000 115,200,000                   
        liabilities and stockholders’ (deficit) equity
      		                                                 
        other current liabilities
      		              1,312,000 1,451,000 1,450,000 1,460,000 1,222,000 1,250,000 1,250,000 1,250,000  4,868,000 3,644,000 8,339,000 6,840,000 4,179,000 3,132,000 3,814,000 3,463,000 2,274,000 1,279,000 1,665,000 1,723,000 1,387,000 265,000 865,000 257,000           
        stockholders’ (deficit) equity:
      		                                                 
        total stockholders’ (deficit) equity
      		             -347,086,000 -226,904,000 -182,218,000 -90,581,000                               151,032,513 152,919,640 
        total liabilities and stockholders’ (deficit) equity
      		             1,705,619,000 1,576,398,000                                   
        ​
      		              2,022,000                                   
        revenues:
      		                                                 
        net product revenue
      		              134,186,000                                   
        collaboration revenue
      		              50,017,000                                 15,455,361 5,867,806 
        royalty revenue
      		              32,924,000                                   
        total revenues
      		              217,127,000                                   
        operating expenses:
      		                                                 
        cost of product sales, excluding amortization of acquired intangible assets
      		              14,011,000                                   
        amortization of acquired intangible assets
      		              31,023,000                                   
        research and development
      		              165,462,000                                 13,886,196 14,712,091 
        selling, general and administrative
      		              80,118,000                                   
        change in the fair value of deferred and contingent consideration
      		              -5,300,000                                   
        total operating expenses
      		              285,314,000                                 20,565,188 21,307,148 
        income from operations
      		              -68,187,000                                   
        interest expense
      		              -20,880,000                                   
        other income
      		              -38,141,000                                   
        income before income tax expense
      		              -127,208,000                                   
        income tax benefit
      		              17,893,000                                   
        net income attributable to common stockholders
      		              -109,315,000                                 -4,416,499 -14,586,578 
        weighted-average shares outstanding:
      		                                                 
        basic and diluted
      		              71,654,671,000                                   
        net income per share
      		              -1,530                                 -0.19 -5.51 
        total liabilities and stockholders’ equity
      		               1,804,057,000 1,799,591,000 1,938,056,000 2,007,325,000 2,058,669,000 2,111,941,000 2,208,278,000 2,181,059,000 1,476,637,000 1,545,592,000 1,623,782,000 1,641,486,000 1,291,572,000 1,283,911,000 1,119,222,000 1,028,627,000 511,773,000 379,411,000 391,653,000 367,720,000 383,078,000 248,645,000 269,345,000 288,177,000 305,563,000 335,232,000 396,100,000 273,822,000 299,520,000 220,795,000 237,558,000 255,840,000   
        liabilities and stockholders’ equity
      		                                                 
        stockholders’ equity:
      		                                                 
        total stockholders’ equity
      		                 1,438,000 104,926,000 196,577,000 292,576,000 481,982,000 510,954,000 572,494,000 528,734,000 594,330,000 663,654,000 488,685,000 512,942,000 350,727,000 386,090,000 267,402,000 150,308,000 156,437,000 145,882,000 169,731,000 100,827,000 119,583,000 140,177,000 165,624,000 196,001,000 269,151,000 248,581,000 273,320,000 201,296,000 223,756,000 244,342,000   
        trade receivables
      		                  96,645,000 78,801,000 94,124,000 69,929,000 56,786,000 53,644,000 52,623,000 55,538,000 60,383,000 77,104,000 46,350,000 67,907,000 42,197,000 59,383,000 45,611,000 40,394,000 38,744,000 33,767,000 32,173,000 24,929,000 27,409,000 19,765,000 22,618,000         
        deferred consideration payable
      		                       2,384,000 40,000,000  19,700,000 19,400,000 19,300,000  38,200,000                   
        deferred revenue- long term
      		                        1,768,000                         
        deferred consideration payable- current
      		                         40,000,000    19,400,000                    
        deferred revenue- long-term
      		                         3,415,000                        
        deferred consideration payable- long-term
      		                             18,300,000                    
        deferred revenue - long-term
      		                             9,722,000 11,156,000 10,540,000 9,300,000 7,954,000 6,579,000 3,828,000 2,194,000 1,587,000            
        receivables
      		                                         8,016,000 5,114,000 3,178,000 1,296,000     
        preferred stock, 0.001 par value. undesignated 5,000,000 shares; issued and outstanding 0 shares at september 30, 2014 and december 31, 2013
      		                                                 
        grant and collaboration receivables
      		                                             858,000 838,000 783,851 870,641 
        preferred stock, 0.001 par value. undesignated 5,000,000 shares; issued and outstanding 0 shares at june 30, 2014 and december 31, 2013
      		                                                 
        preferred stock, 0.001 par value. undesignated 5,000,000 shares; issued and outstanding 0 shares at march 31, 2014 and december 31, 2013
      		                                                 
        liabilities, convertible preferred stocks and stockholders’ (deficit) equity
      		                                                 
        deferred revenue, less current portion
      		                                                241,667 
        long-term debt, less current portion
      		                                                 
        series one convertible preferred stock, designated 2,000,000 shares; issued and outstanding 1,483,337 shares at december 31, 2012
      		                                                 
        series two convertible preferred stock, designated 13,750,000 shares; issued and outstanding 10,701,405 shares at december 31, 2012
      		                                                 
        series three convertible preferred stock, designated 13,750,000 shares; issued and outstanding 2,853,517 shares at december 31, 2012
      		                                                 
        preferred stock, 0.001 par value. undesignated 5,000,000 shares; issued and outstanding 0 shares at september 30, 2013
      		                                                 
        total liabilities, convertible preferred stocks and stockholders’ (deficit) equity
      		                                               167,244,115 175,468,084 
        grant revenue
      		                                               834,212 986,406 
        total revenues and non-cash cancellation revenue
      		                                               16,289,573 6,854,212 
        general and administrative
      		                                               6,678,992 6,595,057 
        interest income
      		                                               26,695  
        loss on extinguishment of debt
      		                                                 
        net income
      		                                                 
        deemed dividend
      		                                                 
        gain on exchange of convertible preferred stock in connection with recapitalization
      		                                                 
        less beneficial conversion charge
      		                                                 
        basic
      		                                               23,803,282 2,648,832 
        diluted
      		                                               23,803,282 2,648,832 
        preferred stock, 0.001 par value. undesignated 5,000,000 shares; issued and outstanding 0 shares at june 30, 2013
      		                                                 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-09-30 2015-06-30 2015-03-31 2014-09-30 2014-06-30 2014-03-31 2013-09-30 
                                                        
          cash flows from operating activities
        		                                                
          net income
        		-2,809,000 -134,965,000 15,896,000 -64,849,000 866,562,000                                            
          adjustments to reconcile net income to net cash from operating activities:
        		                                                
          depreciation and amortization
        		15,413,000 12,902,000 11,109,000 7,583,000 7,221,000 6,764,000 6,486,000 7,018,000 55,395,000 80,705,000 62,055,000 51,005,000 42,825,000 38,865,000 89,915,506 29,180 26,314 18,811,000 16,750,000 14,986,000 13,587,000 12,402,000 11,643,000 10,210,000 9,235,000 9,277,000 8,143,000 7,701,000 7,059,000 6,771,000 7,073,000 6,221,000 6,022,000 5,939,000 10,295,000              
          non-cash operating lease expense
        		1,761,000 1,832,000 2,001,000 1,844,000 1,790,000 1,480,000 1,800,000 2,680,000 1,792,000 1,671,000 2,482,000 2,732,000 2,942,000 2,379,000 7,500,705 2,387 1,908 1,870,000 1,850,000 1,847,000 1,819,000 1,789,000 1,894,000                          
          non-cash royalty revenue related to sale of future royalties
        		-46,835,000 -79,408,000 -64,061,000 -52,125,000 -32,974,000 -52,630,000 -55,528,000 -48,121,000 -25,228,000 -42,861,000 -21,540,000 -15,822,000 -13,237,000 -17,121,000 -31,599,518 -9,369 -8,113 -9,143,000 -5,636,000 -5,823,000 -2,858,000 -1,756,000                           
          non-cash interest expense on liability related to sale of future royalties
        		65,699,000 65,853,000 49,976,000 49,668,000 49,661,000 52,355,000 52,699,000 52,276,000 50,064,000 48,759,000 18,278,000 18,851,000 18,902,000 16,861,000 55,740,175 18,951 18,874 19,928,000 19,672,000 20,003,000 18,080,000 17,260,000                           
          change in valuation of contingent consideration
        		 0 0 0 -800,000 -10,175,000 700,000 5,100,000 -100,000 -2,700,000 1,500,000                                      
          tangible asset impairment and losses on transactions
        		927,000                                                
          unrealized loss on clearpoint equity investments
        		   -44,000 3,122,000 -3,731,000 -5,206,000 1,261,000 -9,000 -1,592,000 1,995,000 1,073,000 39,000 2,447,000   1,049   2,654,000 -6,764,000                            
          unrealized gain on marketable securities - equity investments
        		-1,214,000 -800,000 -1,622,000 -764,000 -774,000                                            
          deferred income taxes
        		-10,000 1,000   2,000 -55,910,000 -3,000 2,000 -1,000 3,979,000 -2,000 -50,903,000 -4,000                                    
          amortization of discounts on investments
        		-4,114,000 -5,050,000 -6,103,000 -4,556,000 -2,313,000  -2,954,000 -3,296,000 -3,697,000              76,000 -302,000 -333,000  -467,000                      
          amortization of debt issuance costs
        		305,000 313,000 305,000 302,000 299,000 307,000 300,000 295,000 296,000 299,000 573,000 563,000 438,000 585,000 1,315,065 471 464 471,000 466,000 459,000 452,000 254,000 256,000 254,000 256,000 260,000 154,000 141,000 139,000 134,000 134,000 130,000 126,000 125,000 123,000 105,000 80,000 78,000 77,000 75,000 72,000        
          share-based compensation expense
        		23,421,000 18,518,000 19,426,000 18,543,000 18,060,000 17,239,000 19,755,000 19,243,000 18,378,000 16,508,000 26,942,000 29,371,000 28,815,000 27,344,000 82,934,681 27,730 26,589 26,236,000 25,871,000 25,699,000 25,707,000 21,416,000 16,779,000 16,910,000 15,220,000 11,466,000 10,484,000 10,921,000 9,263,000 8,479,000 8,942,000 8,083,000 7,748,000 6,477,000 7,168,000 7,885,000 9,029,000 8,399,000 8,959,000 8,736,000 8,915,000 8,054,000 8,328,000 9,748,000 4,622,000 4,278,000 3,705,000 2,639,697 
          unrealized foreign currency transaction losses
        		-887,000 -1,388,000 -171,000 2,688,000 2,251,000 -10,227,000   269,000 -17,507,000 16,726,000 -3,275,000 -10,057,000 -57,983,000 71,209,641 34,224 2,135 14,111,000 17,297,000    -23,829,000 -11,923,000 8,675,000  143,000 -803,000 865,000   536,000 -1,300,000 -95,000 -2,012,000 828,000 820,000 -199,000 438,000          
          changes in operating assets and liabilities:
        		                                                
          inventory
        		2,643,000 -26,779,000 -18,526,000 -10,782,000 2,191,000 11,086,000 -3,106,000 -1,936,000 120,000 5,938,000 -4,326,000 -5,183,000 -4,612,000 -5,900,000 -768,027 -323 350 -676,000 570,000 -57,000 1,963,000 1,451,000 -553,000 841,000 102,000 -1,882,000 -722,000 -518,000 -334,000 -2,571,000 141,000 -1,947,000 -1,446,000 -2,829,000 -819,000 -1,456,000 -1,350,000            
          prepaid expenses and other current assets
        		1,180,000 -22,942,000 -1,679,000 4,232,000 -16,429,000 -9,194,000 8,166,000 5,887,000 93,904,000 -104,459,000 -4,484,000 6,340,000 57,611,000 -16,006,000 -35,631,431 -8,687 25,118 -23,471,000 -7,488,000 44,000 15,605,000 -3,332,000 7,280,000 -9,894,000 -6,675,000 2,936,000 -4,521,000 -7,059,000 -191,000 -308,000 -1,555,000 -704,000 958,000 -1,214,000 -154,000 -509,000 93,000 76,000 -68,000 461,000 702,000        
          trade and royalty receivables
        		-40,390,000 22,214,000 -6,474,000 21,901,000 -47,792,000 40,761,000 -7,719,000 8,190,000 -39,500,000 8,348,000 8,135,000 25,404,000 -43,426,000 -23,695,000 -24,743,451 -1,177 -28,372                                
          deposits and other assets
        		-1,588,000 1,137,000 2,328,000 -216,000 -611,000 4,550,000 -2,153,000 -1,130,000 11,192,000 625,000 -2,339,000 6,193,000 743,000 839,000 -3,751,026 -464 -510 212,000 -155,000 -425,000 136,000 -445,000 -42,000 5,644,000 -5,819,000 -3,176,000 -5,091,000 1,098,000 -10,754,000 -708,000 34,000 -111,000 -308,000 -59,000 -22,000 -237,000 -226,000 -124,000    -75,000 120,000 138,000   17,000 -6,877 
          accounts payable and accrued expenses
        		-68,713,000 108,082,000 -43,205,000 -11,638,000 18,502,000 -32,905,000 18,285,000 -13,313,000 -5,389,000 7,912,000 7,997,000 -1,087,000 33,524,000 25,974,000 1,577,060 21,620 -30,680 36,771,000 18,111,000 19,533,000 -28,756,000 16,408,000 61,887,000 -3,497,000 -4,000,000 26,141,000 8,241,000 21,107,000 -28,653,000 25,271,000 16,381,000 9,035,000 -6,810,000 12,204,000 -645,000 16,375,000 -3,923,000 2,179,000          147,022 
          other liabilities
        		-2,309,000 9,101,000 -9,177,000 -16,862,000 -458,000 16,563,000 -1,841,000 -8,876,000 5,984,000 -551,000 1,299,000 933,000 -3,988,000 -3,650,000 -903,833 -1,078 -3,089 -2,364,000 -1,257,000 -1,167,000 -1,916,000 166,000   1,264,000 1,115,000 3,902,000 586,000 8,065,000 315,000 1,132,000 960,000 -475,000  350,000 1,081,000 -624,000            
          deferred revenue
        		-1,522,000 300,000 -8,143,000 -3,355,000 7,200,000 5,718,000 0 0 -801,000 -423,000 1,224,000 -214,000 -1,137,000     45,000 30,000 -1,931,000 -2,154,000 -2,092,000 -2,015,000 -2,725,000 -1,200,000 -2,969,000 -930,000 1,937,000 574,000 581,000 2,729,000 1,795,000 1,409,000 -1,241,000 6,106,000 4,022,000 582,000 758,000 181,000 344,000 243,000        
          payments on contingent consideration
        		 0 0 0 -4,684,000 0                                           
          net cash from operating activities
        		-59,042,000 -34,273,000 -66,301,000 -58,333,000 870,103,000 -30,004,000 -76,992,000 -71,453,000 70,761,000 -100,288,000 -14,519,000 -14,120,000 -29,491,000 -165,963,000 -190,538,354 -55,242 -97,404 -68,840,000 -51,190,000 -31,145,000 -100,157,000 -64,366,000 26,659,000 -74,810,000 -81,554,000 -10,206,000 -15,502,000 -30,522,000 -42,409,000 -15,143,000 3,377,000 3,000 -15,878,000 21,288,000 -15,769,000 13,320,000 -28,902,000 -13,319,000           
          capital expenditures
        		0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0           
          free cash flows
        		-59,042,000 -34,273,000 -66,301,000 -58,333,000 870,103,000 -30,004,000 -76,992,000 -71,453,000 70,761,000 -100,288,000 -14,519,000 -14,120,000 -29,491,000 -165,963,000 -190,538,354 -55,242 -97,404 -68,840,000 -51,190,000 -31,145,000 -100,157,000 -64,366,000 26,659,000 -74,810,000 -81,554,000 -10,206,000 -15,502,000 -30,522,000 -42,409,000 -15,143,000 3,377,000 3,000 -15,878,000 21,288,000 -15,769,000 13,320,000 -28,902,000 -13,319,000           
          cash flows from investing activities
        		                                                
          purchases of fixed assets
        		-1,197,000 -2,374,000 -3,445,000 -1,317,000 -1,724,000 -3,767,000 -522,000 7,375,000 -9,588,000 -5,566,000 -6,357,000 -6,245,000 -10,270,000 -8,622,000 -23,375,988 -8,700 -9,312 -8,726,000 -5,844,000 -7,974,000 -5,669,000 -6,352,000 -3,308,000 -2,160,000 -6,023,000 -4,653,000 -4,253,000 -1,986,000 -2,865,000 -4,608,000 -1,302,000 -708,000 -479,000 -2,043,000 -479,000 -354,000 -225,000 -1,236,000           
          proceeds from sale of fixed assets
        		 0 0 0 70,000 0 18,000                                          
          purchases of marketable securities- available for sale
        		-454,670,000 -312,263,000 -204,103,000 -524,829,000 -322,335,000 -131,304,000 -184,946,000 -187,361,000 -104,373,000     -12,335,000 -40,388,571 -1,394 -39,035 -56,772,000 -83,445,000 -50,946,000 -141,985,000                            
          purchases of marketable securities- equity investments
        		-23,957,000 -7,091,000 -29,508,000 -11,820,000 -5,209,000 -9,763,000 -32,208,000 -8,341,000 -9,065,000 -12,020,000 -8,219,000   0    -4,636,000 -5,382,000 0 -200,000,000                            
          sale of marketable securities- available for sale
        		376,359,000                                                
          sale of marketable securities- equity investments
        		9,885,000                                                
          acquisition of product rights and licenses
        		-156,000 -34,917,000 -252,750,000 -2,677,000 -808,000 -2,730,000 -10,254,000 0 -54,763,000 -22,896,000 -22,849,000 -13,039,000 -33,397,000 -18,375,000 -101,987,574 -9,292 -72,134 -15,312,000 -19,968,000 -7,646,000 -14,192,000 -12,516,000 -23,196,000 9,012,000 -11,434,000  -8,269,000   -1,451,000                   
          net cash from investing activities
        		-93,736,000 34,008,000 -289,623,000 -422,009,000 -184,360,000 267,712,000 -42,675,000 -65,923,000 -114,932,000 -94,418,000 -29,596,000 -23,752,000 -28,971,000 32,439,000 257,620,703 72,254 49,043 68,274,000 64,704,000 56,057,000 30,147,000 -208,120,000 -394,211,000 142,057,000 -101,274,000 -228,997,000 30,429,000 -38,171,000 -150,498,000 -24,596,000 -24,113,000 7,744,000 -1,648,000 -54,042,000 19,272,000 23,469,000 24,418,000 23,131,000 38,236,000   -6,284,000       
          cash flows from financing activities
        		                                                
          proceeds from exercise of options
        		6,403,000 59,387,000 16,830,000 1,134,000 15,751,000 23,245,000 573,000 2,717,000 2,030,000 269,000 3,446,000 14,670,000 5,655,000 1,429,000 13,199,802 754 2,444 1,189,000 2,976,000 1,389,000 11,755,000 37,192,000 7,942,000 15,058,000 9,987,000 6,081,000 8,066,000 2,848,000 1,281,000 2,237,000 5,039,000 2,456,000 1,136,000 745,000 902,000 429,000 106,000 42,000 892,000 0 34,000 617,000 5,053,000 3,019,000 359,000    
          payments on contingent consideration obligation
        		 0 0 0 -6,341,000                                            
          net cash from financing activities
        		6,403,000 302,504,000 15,219,000 3,961,000 9,410,000 26,471,000 -17,627,000 246,482,000 540,000 620,485,000 3,361,000 18,460,000 4,094,000 302,918,000 -134,971,029 3,861 1,168 4,354,000 2,976,000 4,016,000 9,531,000 40,089,000 643,054,000 -32,918,000 18,490,000 2,284,000 382,354,000 2,849,000 225,722,000 3,726,000 5,080,000 121,629,000 1,136,000 1,851,000 1,707,000 39,997,000 663,000 42,000 892,000    5,053,000 3,019,000 359,000 218,000 118,146,000 -2,856,428 
          effect of exchange rate changes on cash
        		-1,524,000 9,795,000 -6,064,000 13,588,000 5,393,000 -8,653,000 8,542,000 -5,187,000 -2,030,000 3,095,000 -2,332,000 10,314,000 -7,963,000 6,020,000 -8,795,347 1,694 1,653 -3,888,000 -4,019,000 1,787,000 -1,701,000 7,239,000 7,000 845,000 -403,000 1,370,000 -2,298,000 794,000 -1,169,000 -1,402,000 -1,219,000 -3,263,000 2,273,000 857,000 3,617,000 2,119,000 -394,000 -1,819,000 -425,000 -919,000 1,579,000        
          net increase in cash and cash equivalents
        		-147,899,000   -462,793,000 700,546,000                    -164,741,000 -235,549,000 394,983,000 -65,050,000 31,646,000 -37,415,000 -16,875,000   -30,046,000 8,827,000   8,035,000       31,701,000 -94,683,000 100,441,000 -130,050,450 
          cash and cash equivalents, and restricted cash beginning of period
        		998,334,000 0 0 0 795,316,000 0 0 0 610,284,000 0 0 0 295,925,000 0 197,020,782 0 197,218 0 0 0 216,312,000 0 0 0 295,528,000                        
          cash and cash equivalents, and restricted cash end of period
        		850,435,000 312,034,000 -346,769,000 -462,793,000 1,495,862,000 255,526,000 -128,752,000 103,919,000 564,623,000 428,874,000 -43,086,000 -9,098,000 233,594,000 175,414,000 120,336,755 22,567 151,678 -100,000 12,471,000 30,715,000 154,132,000 -225,158,000 275,509,000 35,174,000 130,787,000 -235,549,000                       
          supplemental disclosure of cash information
        		                                                
          cash paid for interest
        		2,156,000 0 3,546,000 0 2,156,000 0 2,157,000 0 3,666,000  11,710,000 9,354,000 12,956,000  12,670,727 2,143 6,130 -1,000 4,407,000 0 5,182,000    4,878,000  3,931,000 0 3,111,000 846,000 3,089,000 815,000 3,023,000 775,000 3,022,000 224,000 2,250,000 0 2,250,000 0 2,263,000    0 0 1,000 83,115 
          supplemental disclosure of non-cash investing and financing activity
        		                                                
          unrealized loss on marketable securities, net of tax
        		-1,517,000   -186,000 -88,000          -2,329,931 -156 -2,913    -1,294,000                            
          right-of-use assets obtained in exchange for operating lease obligations
        		 0 26,825,000 0 850,000 676,000 4,063,000 0 1,723,000      35,225,358 68,055 587   0 13,000                            
          decrease in right-of-use assets related to lease modifications and termination
        		1,466,000                                                
          decrease in operating lease liabilities due to lease modifications and termination
        		1,547,000                                                
          fixed asset additions through tenant improvement allowance
        		 0 381,000 11,000 374,000 173,000 1,936,000                                          
          intangible asset impairment
        		         0 0                                      
          tangible asset impairment
        		 500,000 419,000   2,609,000 1,318,000                                          
          loss on sale of fixed assets
        		 0 53,000 0 77,000 0 526,000                                          
          gain on lease terminations
        		     0 0                                          
          gain on lease modification
        		                                                
          gain on sale of priority review voucher
        		                                                
          unrealized loss on clearpoint convertible debt security
        		     0 0   -1,916,000 3,055,000 1,598,000 -59,000 3,348,000   1,542   3,532,000 -7,858,000   -2,050,000 2,799,000                        
          realized loss on sale of clearpoint equity investment
        		                                                
          realized loss on clearpoint convertible debt security
        		     0                                           
          realized gain on sale of marketable securities - equity investments
        		                                                
          non-cash stock consideration, milestone payment
        		         0 0                                      
          disposal of asset
        		 0    269,000   544,000 671,000 2,000      79                                
          loss on extinguishment of debt
        		                                                
          proceeds from sale of priority review voucher
        		                                                
          sale of clearpoint equity investments
        		                                                
          proceeds from settlement of clearpoint convertible debt security
        		                                                
          proceeds from employee stock purchase plan
        		 3,117,000 0   3,226,000 0   2,149,000 0   3,343,000 3,103,893   3,165,000 0   2,897,000 0                          
          repayment of senior secured term loan
        		                     0 -18,333,000 -5,000,000 -5,000,000 -5,000,000 -5,000,000                      
          debt extinguishment costs related to senior secured term loan
        		                                                
          cash consideration received from a&r royalty purchase agreement
        		                                                
          debt issuance costs related to senior secured term loan
        		         0 -85,000 -15,000 -182,000                                    
          payment of finance lease principal
        		 0    0 0 0 -1,490,000 0 0 0 -1,379,000 0 -1,274,724 0 -1,276 0 0 0 -2,224,000 0 -2,829,000                          
          total income taxes paid, net of refunds received:
        		                                                
          federal
        		                                                
          state:
        		                                                
          illinois
        		                                                
          other state
        		                                                
          foreign:
        		                                                
          brazil
        		                                                
          other foreign
        		                                                
          total income taxes paid, net of refunds received
        		                                                
          unrealized gain on marketable securities, net of tax
        		 116,000    -2,261,000 2,760,000 -112,000 -444,000  19,000 397,000 54,000      -136,000      -63,000                        
          accrued brokerage fees in connection with sale of priority review voucher
        		                                                
          milestone payable
        		 -32,084,000 7,350,000   -38,975,000 12,500,000 35,000,000 2,500,000  0 -30,000,000 32,500,000  49,950,000                                  
          capital expenditures unpaid at the end of the period
        		                                                
          unrealized gain on clearpoint equity investments
        		                                                
          sale and redemption of marketable securities- available for sale
        		  177,200,000 110,401,000 136,750,000 258,773,000 154,186,000 75,000,000 61,650,000 0 0 9,044,000 12,500,000 63,244,000 341,732,466 90,433 167,101 150,179,000 178,603,000 122,623,000 392,093,000                            
          sale and redemption of marketable securities- equity investments
        		  22,983,000 8,233,000 8,896,000 6,503,000 21,051,000 19,366,000 1,207,000 120,150,000 7,829,000 2,053,000 2,196,000 8,527,000 104,427,370 1,207 2,423 3,541,000                               
          proceeds from sale of future royalties
        		                                                
          net decrease in cash and cash equivalents
        		        -45,661,000  -43,086,000 -9,098,000 -62,331,000  -76,684,027 22,567 -45,540 -100,000 12,471,000 30,715,000 -62,180,000 -225,158,000 275,509,000          -14,117,000    -4,215,000            
          cash paid for income taxes
        		  936,000 36,148,000 3,040,000 4,769,000 6,664,000 4,075,000 2,042,000  4,435,000 6,981,000 2,215,000  4,026,051 962 1,987 2,181,000 1,400,000 3,440,000 687,000    507,000  918,000 476,000 537,000 664,000 161,000 432,000 326,000 485,000 282,000 306,000 28,000 310,000 369,000 39,000 225,000        
          unrealized gain on clearpoint convertible debt security
        		        -166,000             -18,619,000                           
          net loss
        		     -65,886,000 -106,654,000 -99,179,000 -91,576,000 -155,792,000 -132,970,000 -198,883,000 -138,959,000 -170,889,000 -387,849,187 -152,087 -126,726 -143,265,000 -133,624,000 -118,370,000 -128,642,000 -74,354,000 -69,692,000 -181,427,000 -112,687,000 -77,677,000 -59,997,000 -41,789,000 -72,113,000 -48,330,000 -50,969,000 -9,519,000 -19,263,000 1,270,000 -33,738,000 -17,475,000 -29,057,000 -26,796,000 -35,167,000 -38,914,000 -41,233,000 -43,223,000 -38,361,000 -37,915,000 -27,282,000 -25,104,000 -14,098,000 -4,416,499 
          adjustments to reconcile net loss to net cash from operating activities:
        		                                                
          realized loss for the sale of clearpoint equity investment
        		                                                
          realized gain on redemption of marketable securities - equity investments
        		                                                
          unrealized loss on marketable securities - equity investments
        		                                                
          amortization of premiums on investments
        		         -2,111,000 -1,000 -3,000 -85,000 -79,000 1,790,460 653 887 1,247,000 1,408,000 1,285,000 1,359,000        -257,000    -96,000 42,000 128,000 157,000 208,000 275,000 470,000 509,000 631,000 404,000 429,000 486,000 315,000 496,000 414,000  
          non-cash foreign currency remeasurement loss on intercompany loan
        		                                                
          sale and redemption of clearpoint equity investments
        		         0 0                                      
          proceeds from issuance of senior secured term loan
        		                                                
          repayment of convertible notes
        		             0                                   
          proceeds from stock purchase agreement
        		                                                
          unrealized gain on marketable securities- equity investments
        		      -812,000 -401,000 -710,000         -323,000 -656,000                              
          proceeds from principal payment of clearpoint convertible debt security
        		                                                
          proceeds from sales of future royalties
        		      0                                          
          debt issuance costs related to secured loan
        		                                                
          unrealized foreign currency transaction gains
        		                    24,691,000                            
          realized gain on redemption of marketable securities- equity investments
        		                                                
          unrealized loss on marketable securities- equity investments
        		         2,967,000 -1,120,000 -2,198,000 -2,166,000 -3,327,000 11,307,644 4,879 6,477    302,000                            
          purchase of equity investment in clearpoint
        		                 0 0 0 -100,000                            
          payments on deferred and contingent consideration obligation
        		                                                
          realized loss on the sale of clearpoint equity investment
        		                                                
          capital expenditures unpaid at the end of period
        		           8,000 28,000                                    
          change in valuation of deferred and contingent consideration
        		            2,400,000 6,300,000 -32,173,100 -15,200 -11,700 -12,100,000 10,800,000 700,000 100,000 6,300,000 8,400,000 7,680,000 900,000  9,500,000 5,300,000 21,160,000                    
          non-cash finance lease amortization expense
        		                     0 170,000                          
          settlement of deferred and contingent consideration
        		                     0 0                          
          non-cash stock consideration, acquisition
        		                     0 0                          
          non-cash interest expense
        		                     5,920,000 5,685,000 5,534,000 5,459,000 5,444,000 2,528,000 2,073,000 1,982,000 1,955,000 1,919,000 1,864,000 1,780,000 1,756,000 1,725,000 1,674,000 1,600,000 1,578,000 1,546,000 1,495,000 1,446,000        
          purchase of convertible debt security
        		                     0 0 0 -10,000,000                        
          termination and exit fees related to payoff of senior secured term loan
        		                                                
          net proceeds from public offerings
        		                     0 9,142,000 5,447,000 13,503,000  99,717,000 104,000 224,441,000  41,000              0    
          cash consideration received from royalty purchase agreement
        		                     0                           
          loss on disposal of asset
        		              80,918        -1,000            -42,000              
          proceeds from issuance of convertible notes
        		                         -304,000                       
          termination and exit fees related to payoff of secured term loan
        		                     0                           
          payments on deferred consideration obligation
        		                     0 -2,271,000                          
          trade receivables
        		                  -19,205,000 15,590,000 -25,010,000 -10,604,000 -1,739,000 -486,000 2,346,000 5,646,000 15,581,000 -30,488,000 20,786,000 -26,908,000 17,748,000 -16,206,000 -4,223,000 -1,209,000 -4,232,000 -16,000 -6,746,000 1,193,000           
          right-of-use assets obtained in exchange for finance lease obligations
        		                                                
          issuance of common stock related to rights exchange
        		                                                
          unrealized gain on equity investment in clearpoint
        		                                                
          purchases of marketable securities
        		                     -432,719,000 -639,844,000 -68,288,000 -298,814,000 -254,682,000 -13,125,000 -60,538,000 -165,723,000 -39,958,000 0 -5,973,000 -22,683,000 -61,901,000 0 0 -19,467,000 -11,685,000           
          sale and redemption of marketable securities
        		                     243,467,000 272,137,000 203,493,000 224,997,000  56,076,000 40,334,000 18,090,000  29,984,000 14,425,000 21,514,000  20,490,000 100,247,000 44,110,000  65,937,000          
          purchase of equity investment
        		                                                
          business acquisition, net of cash acquired
        		                             0                   
          unrealized gain on equity investment
        		                                                
          unrealized loss on equity investment
        		                                                
          other long-term liabilities
        		                                     -1,481,000 681,000          
          non-cash lease expense
        		                        1,330,000                        
          unrealized loss on equity investment in clearpoint
        		                        1,574,000                        
          right-of-use assets obtained in exchange for lease obligations
        		                        22,642,000   329,000 11,314,000                    
          change in the fair value of deferred and contingent consideration
        		                                                
          sale & redemption of marketable securities
        		                                        41,795,000   40,598,000     
          acquisition of product rights
        		                             -4,530,000                   
          proceeds from shares issued under employee stock purchase plan
        		                         2,013,000 0   1,488,000 0   1,106,000 805,000 0 557,000            
          debt issuance costs related to secured term loan
        		                                 0 0              
          net proceeds from public offering
        		                                                
          proceeds from issuance of secured term loan
        		                                 0 0              
          cash and cash equivalents, beginning of period
        		                           0 169,498,000 0 0 0 111,792,000 0 0 0 58,321,000 0 0 0 58,022,000 0 0 49,748,000 0 0 15,414,000 0 
          change in valuation of warrant liability
        		                                  0   -91,000 -3,000     41,000 40,000 -17,000 55,000  
          unrealized gain on mri investment
        		                          -2,400,000                      
          purchases of equity investment in mri
        		                          0                      
          change in unrealized gain on marketable securities, net of tax
        		                          -463,000 839,000 59,000 59,000      -9,000 -22,000  -189,000          
          cash and cash equivalents, end of period
        		                           -65,050,000 201,144,000 -37,415,000 -16,875,000 126,113,000 97,675,000 -30,046,000 8,827,000 78,905,000 54,106,000 8,035,000 14,628,000 -4,507,000 40,165,000 111,492,000 -7,605,000 36,825,000 31,701,000 -94,683,000 115,855,000 -130,050,450 
          benefit for deferred income taxes
        		                                     23,000           
          supplemental disclosures of non-cash information related to investing and financing activities
        		                                                
          amortization of premiums and accretion of discounts on investments
        		                              -124,000                  
          acquisition, including transaction costs
        		                                 0 -739,000              
          debt issuance costs related to convertible notes
        		                                                
          change in unrealized gain on marketable securities
        		                                        658,000     10,000 10,000  
          depreciation
        		                                    612,000 813,000 813,000 815,000 849,000 760,000 685,000 634,000 543,000 562,000 588,000 588,556 
          payments on long-term debt
        		                                                
          net cash provided by investing activities
        		                                        22,117,000        
          net cash provided by financing activities
        		                                        34,000        
          receivables
        		                                           1,267,000     
          sales & redemptions of marketable securities
        		                                                
          change in unrealized loss on marketable securities
        		                                               -39,695 
          net cash provided/(used in) investing activities
        		                                           20,607,000     
          change in unrealized gain (loss) on marketable securities
        		                                           125,000     
          grant and collaboration receivables
        		                                             -20,000 120,000 86,790 
          net proceeds from sale of series four convertible preferred stock
        		                                               0 
          change in carry value of preferred securities resulting from recapitalization
        		                                               0 
          maturities of marketable securities
        		                                             31,806,000 21,273,000 6,487,191 
          ipo closing costs included in accounts payable and accrued expenses
        		                                                
          net proceeds from secondary offering
        		                                              118,183,000  
          net proceeds from sale of series one convertible preferred stock
        		                                                
          net proceeds from initial public offering
        		                                               -70,629 
          noncash interest expense
        		                                                
          supplemental disclosures of noncash information related to investing and financing activities