7Baggers
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-09-30 2015-06-30 2015-03-31 2014-09-30 2014-06-30 2014-03-31 2013-09-30 
      
    		                                              
      cash flows from operating activities
    		                                              
      net income
    		15,896,000 -64,849,000 866,562,000 -65,886,000 -106,654,000 -99,179,000 -91,576,000 -155,792,000 -132,970,000 -198,883,000 -138,959,000 -170,889,000 -109,315,000 -152,087,000 -126,726,000 -143,265,000 -133,624,000 -118,370,000 -128,642,000 -74,354,000 -69,692,000 -181,427,000 -112,687,000 -77,677,000 -59,997,000 -41,789,000 -72,113,000 -48,330,000 -50,969,000 -9,519,000 -19,263,000 1,270,000 -33,738,000 -17,475,000 -29,057,000 -26,796,000 -35,167,000 -38,914,000 -41,233,000 -43,223,000 -38,361,000 -37,915,000 -27,282,000 -25,104,000 -14,098,000 -4,416,499 
      adjustments to reconcile net income to net cash from operating activities:
    		                                              
      depreciation and amortization
    		11,109,000 7,583,000 7,221,000 6,764,000 6,486,000 7,018,000 55,395,000 80,705,000 62,055,000 51,005,000 42,825,000 38,865,000 34,477,000 29,180,000 26,314,000 18,811,000 16,750,000 14,986,000 13,587,000 12,402,000 11,643,000 10,210,000 9,235,000 9,277,000 8,143,000 7,701,000 7,059,000 6,771,000 7,073,000 6,221,000 6,022,000 5,939,000 10,295,000              
      non-cash operating lease expense
    		2,001,000 1,844,000 1,790,000 1,480,000 1,800,000 2,680,000 1,792,000 1,671,000 2,482,000 2,732,000 2,942,000 2,379,000 3,210,000 2,387,000 1,908,000 1,870,000 1,850,000 1,847,000 1,819,000 1,789,000 1,894,000                          
      non-cash royalty revenue related to sale of future royalties
    		-64,061,000 -52,125,000 -32,974,000 -52,630,000 -55,528,000 -48,121,000 -25,228,000 -42,861,000 -21,540,000 -15,822,000 -13,237,000 -17,121,000 -14,135,000 -9,369,000 -8,113,000 -9,143,000 -5,636,000 -5,823,000 -2,858,000 -1,756,000                           
      non-cash interest expense on liability related to sale of future royalties
    		49,976,000 49,668,000 49,661,000 52,355,000 52,699,000 52,276,000 50,064,000 48,759,000 18,278,000 18,851,000 18,902,000 16,861,000 17,953,000 18,951,000 18,874,000 19,928,000 19,672,000 20,003,000 18,080,000 17,260,000                           
      change in valuation of contingent consideration
    		0 0 -800,000 -10,175,000 700,000 5,100,000 -100,000 -2,700,000 1,500,000                                      
      tangible asset impairment
    		419,000   2,609,000 1,318,000                                          
      loss on sale of fixed assets
    		53,000 0 77,000 0 526,000                                          
      gain on lease terminations
    		   0 0                                          
      unrealized gain on clearpoint equity investments
    		  3,122,000       1,073,000 39,000 2,447,000 3,482,000 -3,418,000 1,049,000 8,454,000                               
      unrealized loss on clearpoint convertible debt security
    		   0 0   -1,916,000              -2,050,000 2,799,000                        
      unrealized gain on marketable securities - equity investments
    		-1,622,000 -764,000 -774,000                                            
      realized loss on clearpoint convertible debt security
    		   0                                           
      disposal of asset
    		   269,000   544,000 671,000 2,000      79,000                                
      deferred income taxes
    		  2,000 -55,910,000 -3,000 2,000 -1,000 3,979,000 -2,000 -50,903,000 -4,000                                    
      amortization of discounts on investments
    		-6,103,000 -4,556,000 -2,313,000  -2,954,000 -3,296,000 -3,697,000              76,000 -302,000 -333,000  -467,000                      
      amortization of debt issuance costs
    		305,000 302,000 299,000 307,000 300,000 295,000 296,000 299,000 573,000 563,000 438,000 585,000 381,000 471,000 464,000 471,000 466,000 459,000 452,000 254,000 256,000 254,000 256,000 260,000 154,000 141,000 139,000 134,000 134,000 130,000 126,000 125,000 123,000 105,000 80,000 78,000 77,000 75,000 72,000        
      share-based compensation expense
    		19,426,000 18,543,000 18,060,000 17,239,000 19,755,000 19,243,000 18,378,000 16,508,000 26,942,000 29,371,000 28,815,000 27,344,000 28,670,000 27,730,000 26,589,000 26,236,000 25,871,000 25,699,000 25,707,000 21,416,000 16,779,000 16,910,000 15,220,000 11,466,000 10,484,000 10,921,000 9,263,000 8,479,000 8,942,000 8,083,000 7,748,000 6,477,000 7,168,000 7,885,000 9,029,000 8,399,000 8,959,000 8,736,000 8,915,000 8,054,000 8,328,000 9,748,000 4,622,000 4,278,000 3,705,000 2,639,697 
      unrealized foreign currency transaction losses (gains)
    		-171,000      269,000         14,111,000 17,297,000        143,000 -803,000 865,000                    
      changes in operating assets and liabilities:
    		                                              
      inventory
    		-18,526,000 -10,782,000 2,191,000 11,086,000 -3,106,000 -1,936,000 120,000 5,938,000 -4,326,000 -5,183,000 -4,612,000 -5,900,000 -795,000 -323,000 350,000 -676,000 570,000 -57,000 1,963,000 1,451,000 -553,000 841,000 102,000 -1,882,000 -722,000 -518,000 -334,000 -2,571,000 141,000 -1,947,000 -1,446,000 -2,829,000 -819,000 -1,456,000 -1,350,000            
      prepaid expenses and other current assets
    		-1,679,000 4,232,000 -16,429,000 -9,194,000 8,166,000 5,887,000 93,904,000 -104,459,000 -4,484,000 6,340,000 57,611,000 -16,006,000 -52,046,000 -8,687,000 25,118,000 -23,471,000 -7,488,000 44,000 15,605,000 -3,332,000 7,280,000 -9,894,000 -6,675,000 2,936,000 -4,521,000 -7,059,000 -191,000 -308,000 -1,555,000 -704,000 958,000 -1,214,000 -154,000 -509,000 93,000 76,000 -68,000 461,000 702,000        
      trade and royalty receivables
    		-6,474,000 21,901,000 -47,792,000 40,761,000 -7,719,000 8,190,000 -39,500,000 8,348,000 8,135,000 25,404,000 -43,426,000 -23,695,000 4,776,000 -1,177,000 -28,372,000                                
      deposits and other assets
    		2,328,000 -216,000 -611,000 4,550,000 -2,153,000 -1,130,000 11,192,000 625,000 -2,339,000 6,193,000 743,000 839,000 -2,778,000 -464,000 -510,000 212,000 -155,000 -425,000 136,000 -445,000 -42,000 5,644,000 -5,819,000 -3,176,000 -5,091,000 1,098,000 -10,754,000 -708,000 34,000 -111,000 -308,000 -59,000 -22,000 -237,000 -226,000 -124,000    -75,000 120,000 138,000   17,000 -6,877 
      accounts payable and accrued expenses
    		-43,205,000 -11,638,000 18,502,000 -32,905,000 18,285,000 -13,313,000 -5,389,000 7,912,000 7,997,000 -1,087,000 33,524,000 25,974,000 10,628,000 21,620,000 -30,680,000 36,771,000 18,111,000 19,533,000 -28,756,000 16,408,000 61,887,000 -3,497,000 -4,000,000 26,141,000 8,241,000 21,107,000 -28,653,000 25,271,000 16,381,000 9,035,000 -6,810,000 12,204,000 -645,000 16,375,000 -3,923,000 2,179,000          147,022 
      other liabilities
    		-9,177,000 -16,862,000 -458,000 16,563,000 -1,841,000 -8,876,000 5,984,000 -551,000 1,299,000 933,000 -3,988,000 -3,650,000 3,259,000 -1,078,000 -3,089,000 -2,364,000 -1,257,000 -1,167,000 -1,916,000 166,000   1,264,000 1,115,000 3,902,000 586,000 8,065,000 315,000 1,132,000 960,000 -475,000  350,000 1,081,000 -624,000            
      deferred revenue
    		-8,143,000 -3,355,000 7,200,000 5,718,000 0 0 -801,000 -423,000 1,224,000 -214,000 -1,137,000     45,000 30,000 -1,931,000 -2,154,000 -2,092,000 -2,015,000 -2,725,000 -1,200,000 -2,969,000 -930,000 1,937,000 574,000 581,000 2,729,000 1,795,000 1,409,000 -1,241,000 6,106,000 4,022,000 582,000 758,000 181,000 344,000 243,000        
      payments on contingent consideration
    		0 0 -4,684,000 0                                           
      net cash from operating activities
    		-66,301,000 -58,333,000 870,103,000 -30,004,000 -76,992,000 -71,453,000 70,761,000 -100,288,000 -14,519,000 -14,120,000 -29,491,000 -165,963,000 -38,045,000 -55,242,000 -97,404,000 -68,840,000 -51,190,000 -31,145,000 -100,157,000 -64,366,000 26,659,000 -74,810,000 -81,554,000 -10,206,000 -15,502,000 -30,522,000 -42,409,000 -15,143,000 3,377,000 3,000 -15,878,000 21,288,000 -15,769,000 13,320,000 -28,902,000 -13,319,000           
      cash flows from investing activities
    		                                              
      purchases of fixed assets
    		-3,445,000 -1,317,000 -1,724,000 -3,767,000 -522,000 7,375,000 -9,588,000 -5,566,000 -6,357,000 -6,245,000 -10,270,000 -8,622,000 -5,382,000 -8,700,000 -9,312,000 -8,726,000 -5,844,000 -7,974,000 -5,669,000 -6,352,000 -3,308,000 -2,160,000 -6,023,000 -4,653,000 -4,253,000 -1,986,000 -2,865,000 -4,608,000 -1,302,000 -708,000 -479,000 -2,043,000 -479,000 -354,000 -225,000 -1,236,000           
      proceeds from sale of fixed assets
    		0 0 70,000 0 18,000                                          
      purchases of marketable securities- available for sale
    		-204,103,000 -524,829,000 -322,335,000 -131,304,000 -184,946,000 -187,361,000 -104,373,000     -12,335,000 0 -1,394,000 -39,035,000 -56,772,000 -83,445,000 -50,946,000 -141,985,000                            
      purchases of marketable securities- equity investments
    		-29,508,000 -11,820,000 -5,209,000 -9,763,000 -32,208,000 -8,341,000 -9,065,000 -12,020,000 -8,219,000   0    -4,636,000 -5,382,000 0 -200,000,000                            
      sale and redemption of marketable securities- available for sale
    		177,200,000 110,401,000 136,750,000 258,773,000 154,186,000 75,000,000 61,650,000 0 0 9,044,000 12,500,000 63,244,000 84,456,000 90,433,000 167,101,000 150,179,000 178,603,000 122,623,000 392,093,000                            
      sale and redemption of marketable securities- equity investments
    		22,983,000 8,233,000 8,896,000 6,503,000 21,051,000 19,366,000 1,207,000 120,150,000 7,829,000 2,053,000 2,196,000 8,527,000 100,801,000 1,207,000 2,423,000 3,541,000                               
      proceeds from settlement of clearpoint convertible debt security
    		                                              
      acquisition of product rights and licenses
    		-252,750,000 -2,677,000 -808,000 -2,730,000 -10,254,000 0 -54,763,000 -22,896,000 -22,849,000 -13,039,000 -33,397,000 -18,375,000 -20,643,000 -9,292,000 -72,134,000 -15,312,000 -19,968,000 -7,646,000 -14,192,000 -12,516,000 -23,196,000 9,012,000 -11,434,000  -8,269,000   -1,451,000                   
      net cash from investing activities
    		-289,623,000 -422,009,000 -184,360,000 267,712,000 -42,675,000 -65,923,000 -114,932,000 -94,418,000 -29,596,000 -23,752,000 -28,971,000 32,439,000 136,445,000 72,254,000 49,043,000 68,274,000 64,704,000 56,057,000 30,147,000 -208,120,000 -394,211,000 142,057,000 -101,274,000 -228,997,000 30,429,000 -38,171,000 -150,498,000   7,744,000 -1,648,000 -54,042,000 19,272,000 23,469,000 24,418,000 23,131,000 38,236,000 20,997,000 22,117,000        
      cash flows from financing activities
    		                                              
      proceeds from exercise of options
    		16,830,000 1,134,000 15,751,000 23,245,000 573,000 2,717,000 2,030,000 269,000 3,446,000 14,670,000 5,655,000 1,429,000 10,005,000 754,000 2,444,000 1,189,000 2,976,000 1,389,000 11,755,000 37,192,000 7,942,000 15,058,000 9,987,000 6,081,000 8,066,000 2,848,000 1,281,000 2,237,000 5,039,000 2,456,000 1,136,000 745,000 902,000 429,000 106,000 42,000 892,000 0 34,000 617,000 5,053,000 3,019,000 359,000    
      proceeds from employee stock purchase plan
    		0   3,226,000 0   2,149,000 0   3,343,000 0   3,165,000 0   2,897,000 0                          
      proceeds from sale of future royalties
    		                                              
      payments on contingent consideration obligation
    		0 0 -6,341,000                                            
      payment of finance lease principal
    		   0 0 0 -1,490,000 0 0 0 -1,379,000 0 0 0 -1,276,000 0 0 0 -2,224,000 0 -2,829,000                          
      net cash from financing activities
    		15,219,000 3,961,000 9,410,000 26,471,000 -17,627,000 246,482,000 540,000 620,485,000 3,361,000 18,460,000 4,094,000 302,918,000 -139,995,000 3,861,000 1,168,000 4,354,000 2,976,000 4,016,000 9,531,000 40,089,000 643,054,000 -32,918,000 18,490,000 2,284,000 382,354,000 2,849,000 225,722,000 3,726,000 5,080,000 121,629,000 1,136,000 1,851,000 1,707,000 39,997,000 663,000 42,000 892,000 0 34,000 145,967,000 5,053,000 3,019,000 359,000 218,000 118,146,000 -2,856,428 
      effect of exchange rate changes on cash
    		-6,064,000 13,588,000 5,393,000 -8,653,000 8,542,000 -5,187,000 -2,030,000 3,095,000 -2,332,000 10,314,000 -7,963,000 6,020,000 -12,139,000 1,694,000 1,653,000 -3,888,000 -4,019,000 1,787,000 -1,701,000 7,239,000 7,000 845,000 -403,000 1,370,000 -2,298,000 794,000 -1,169,000 -1,402,000 -1,219,000 -3,263,000 2,273,000 857,000 3,617,000 2,119,000 -394,000 -1,819,000 -425,000 -919,000 1,579,000        
      net decrease in cash and cash equivalents
    		      -45,661,000  -43,086,000 -9,098,000 -62,331,000  -53,734,000 22,567,000 -45,540,000 -100,000 12,471,000 30,715,000 -62,180,000 -225,158,000 275,509,000          -14,117,000    -4,215,000            
      cash and cash equivalents, and restricted cash beginning of period
    		0 0 795,316,000 0 0 0 610,284,000 0 0 0 295,925,000 0 0 0 197,218,000 0 0 0 216,312,000 0 0 0 295,528,000                        
      cash and cash equivalents, and restricted cash end of period
    		-346,769,000 -462,793,000 1,495,862,000 255,526,000 -128,752,000 103,919,000 564,623,000 428,874,000 -43,086,000 -9,098,000 233,594,000 175,414,000 -53,734,000 22,567,000 151,678,000 -100,000 12,471,000 30,715,000 154,132,000 -225,158,000 275,509,000 35,174,000 130,787,000 -235,549,000                       
      supplemental disclosure of cash information
    		                                              
      cash paid for interest
    		3,546,000 0 2,156,000 0 2,157,000 0 3,666,000  11,710,000 9,354,000 12,956,000  4,406,000 2,143,000 6,130,000 -1,000 4,407,000 0 5,182,000    4,878,000  3,931,000 0 3,111,000 846,000 3,089,000 815,000 3,023,000 775,000 3,022,000 224,000 2,250,000 0 2,250,000 0 2,263,000    0 0 1,000 83,115 
      cash paid for income taxes
    		936,000 36,148,000 3,040,000 4,769,000 6,664,000 4,075,000 2,042,000  4,435,000 6,981,000 2,215,000  1,080,000 962,000 1,987,000 2,181,000 1,400,000 3,440,000 687,000    507,000  918,000 476,000 537,000 664,000 161,000 432,000 326,000 485,000 282,000 306,000 28,000 310,000 369,000 39,000 225,000        
      supplemental disclosure of non-cash investing and financing activity
    		                                              
      unrealized gain on marketable securities, net of tax
    		   -2,261,000 2,760,000 -112,000 -444,000  19,000 397,000 54,000      -136,000      -63,000                        
      right-of-use assets obtained in exchange for operating lease obligations
    		26,825,000 0 850,000 676,000 4,063,000 0 1,723,000      -33,348,000 68,055,000 587,000   0 13,000                            
      fixed asset additions through tenant improvement allowance
    		381,000 11,000 374,000 173,000 1,936,000                                          
      milestone payable
    		7,350,000   -38,975,000 12,500,000 35,000,000 2,500,000  0 -30,000,000 32,500,000  0                                  
      unrealized loss on clearpoint equity investments
    		       -1,592,000                                       
      net increase in cash and cash equivalents
    		 -462,793,000 700,546,000                    -164,741,000 -235,549,000 394,983,000 -65,050,000 31,646,000 -37,415,000 -16,875,000   -30,046,000 8,827,000   8,035,000       31,701,000 -94,683,000 100,441,000 -130,050,450 
      unrealized loss on marketable securities, net of tax
    		 -186,000 -88,000          736,000 -156,000 -2,913,000    -1,294,000                            
      unrealized gain on clearpoint convertible debt security
    		      -166,000     3,348,000 4,387,000 -3,537,000 1,542,000 10,335,000    -18,619,000                           
      unrealized foreign currency transaction losses
    		  2,251,000          34,887,000 34,224,000 2,135,000        8,675,000           828,000 820,000 -199,000 438,000          
      intangible asset impairment
    		       0 0                                      
      gain on lease modification
    		                                              
      gain on sale of priority review voucher
    		                                              
      unrealized (gain) loss on clearpoint equity investments
    		   -3,731,000   -9,000           2,654,000 -6,764,000                            
      realized loss for the sale of clearpoint equity investment
    		                                              
      realized gain on redemption of marketable securities - equity investments
    		                                              
      unrealized (gain) loss on marketable securities - equity investments
    		                                              
      non-cash stock consideration, milestone payment
    		       0 0                                      
      amortization of (discounts) premiums on investments
    		       -2,111,000 -1,000 -3,000 -85,000                -257,000                    
      loss on extinguishment of debt
    		                                              
      unrealized foreign currency transaction (gains) losses
    		         -3,275,000 -10,057,000          -23,829,000         536,000 -1,300,000 -95,000               
      non-cash foreign currency remeasurement loss on intercompany loan
    		                                              
      proceeds from sale of priority review voucher
    		                                              
      sale and redemption of clearpoint equity investments
    		       0 0                                      
      repayment of senior secured term loan
    		                   0 -18,333,000 -5,000,000 -5,000,000 -5,000,000 -5,000,000                      
      debt extinguishment costs related to senior secured term loan
    		                                              
      cash consideration received from a&r royalty purchase agreement
    		                                              
      debt issuance costs related to senior secured term loan
    		       0 -85,000 -15,000 -182,000                                    
      proceeds from issuance of senior secured term loan
    		                                              
      repayment of convertible notes
    		           0                                   
      proceeds from stock purchase agreement
    		                                              
      accrued brokerage fees in connection with sale of priority review voucher
    		                                              
      capital expenditures unpaid at the end of the period
    		                                              
      unrealized gain on marketable securities- equity investments
    		    -812,000 -401,000 -710,000     -3,327,000 -37,000   -323,000 -656,000                              
      proceeds from principal payment of clearpoint convertible debt security
    		                                              
      proceeds from sales of future royalties
    		    0                                          
      debt issuance costs related to secured loan
    		                                              
      unrealized foreign currency transaction gains
    		                  24,691,000                            
      realized gain on redemption of marketable securities- equity investments
    		                                              
      unrealized (gain) loss on marketable securities- equity investments
    		       2,967,000 -1,120,000 -2,198,000 -2,166,000                                    
      purchase of equity investment in clearpoint
    		               0 0 0 -100,000                            
      payments on deferred and contingent consideration obligation
    		                                              
      realized loss on the sale of clearpoint equity investment
    		                                              
      capital expenditures unpaid at the end of period
    		         8,000 28,000                                    
      change in valuation of deferred and contingent consideration
    		          2,400,000 6,300,000 -5,300,000 -15,200,000 -11,700,000 -12,100,000 10,800,000 700,000 100,000 6,300,000 8,400,000 7,680,000 900,000  9,500,000 5,300,000 21,160,000                    
      unrealized (gain) loss on clearpoint convertible debt security
    		          -59,000       3,532,000 -7,858,000                            
      non-cash finance lease amortization expense
    		                   0 170,000                          
      settlement of deferred and contingent consideration
    		                   0 0                          
      non-cash stock consideration, acquisition
    		                   0 0                          
      amortization of premiums on investments
    		           -79,000 252,000 653,000 887,000                -96,000 42,000 128,000 157,000 208,000 275,000 470,000 509,000 631,000 404,000 429,000 486,000 315,000 496,000 414,000  
      non-cash interest expense
    		                   5,920,000 5,685,000 5,534,000 5,459,000 5,444,000 2,528,000 2,073,000 1,982,000 1,955,000 1,919,000 1,864,000 1,780,000 1,756,000 1,725,000 1,674,000 1,600,000 1,578,000 1,546,000 1,495,000 1,446,000        
      purchase of convertible debt security
    		                   0 0 0 -10,000,000                        
      termination and exit fees related to payoff of senior secured term loan
    		                                              
      net proceeds from public offerings
    		                   0 9,142,000 5,447,000 13,503,000  99,717,000 104,000 224,441,000  41,000              0    
      cash consideration received from royalty purchase agreement
    		                   0                           
      loss on disposal of asset
    		            -1,000        -1,000            -42,000              
      unrealized loss on marketable securities- equity investments
    		              6,477,000    302,000                            
      amortization of premiums (discounts) on investments
    		               1,247,000 1,408,000 1,285,000 1,359,000                            
      proceeds from issuance of convertible notes
    		                       -304,000                       
      termination and exit fees related to payoff of secured term loan
    		                   0                           
      payments on deferred consideration obligation
    		                   0 -2,271,000                          
      trade receivables
    		                -19,205,000 15,590,000 -25,010,000 -10,604,000 -1,739,000 -486,000 2,346,000 5,646,000 15,581,000 -30,488,000 20,786,000 -26,908,000 17,748,000 -16,206,000 -4,223,000 -1,209,000 -4,232,000 -16,000 -6,746,000 1,193,000           
      right-of-use assets obtained in exchange for finance lease obligations
    		                                              
      issuance of common stock related to rights exchange
    		                                              
      unrealized gain on equity investment in clearpoint
    		                                              
      purchases of marketable securities
    		                   -432,719,000 -639,844,000 -68,288,000 -298,814,000 -254,682,000 -13,125,000 -60,538,000 -165,723,000 -39,958,000 0 -5,973,000 -22,683,000 -61,901,000 0 0 -19,467,000 -11,685,000           
      sale and redemption of marketable securities
    		                   243,467,000 272,137,000 203,493,000 224,997,000  56,076,000 40,334,000 18,090,000  29,984,000 14,425,000 21,514,000  20,490,000 100,247,000 44,110,000  65,937,000          
      purchase of equity investment
    		                                              
      business acquisition, net of cash acquired
    		                           0                   
      unrealized gain on equity investment
    		                                              
      unrealized loss on equity investment
    		                                              
      other long-term liabilities
    		                                   -1,481,000 681,000          
      non-cash lease expense
    		                      1,330,000                        
      unrealized loss on equity investment in clearpoint
    		                      1,574,000                        
      right-of-use assets obtained in exchange for lease obligations
    		                      22,642,000   329,000 11,314,000                    
      change in the fair value of deferred and contingent consideration
    		                                              
      sale & redemption of marketable securities
    		                                      41,795,000   40,598,000     
      acquisition of product rights
    		                           -4,530,000                   
      proceeds from shares issued under employee stock purchase plan
    		                       2,013,000 0   1,488,000 0   1,106,000 805,000 0 557,000            
      debt issuance costs related to secured term loan
    		                               0 0              
      net proceeds from public offering
    		                                              
      proceeds from issuance of secured term loan
    		                               0 0              
      cash and cash equivalents, beginning of period
    		                         0 169,498,000 0 0 0 111,792,000 0 0 0 58,321,000 0 0 0 58,022,000 0 0 49,748,000 0 0 15,414,000 0 
      change in valuation of warrant liability
    		                                0   -91,000 -3,000     41,000 40,000 -17,000 55,000  
      unrealized gain on mri investment
    		                        -2,400,000                      
      purchases of equity investment in mri
    		                        0                      
      change in unrealized gain on marketable securities, net of tax
    		                        -463,000 839,000 59,000 59,000      -9,000 -22,000  -189,000          
      cash and cash equivalents, end of period
    		                         -65,050,000 201,144,000 -37,415,000 -16,875,000 126,113,000 97,675,000 -30,046,000 8,827,000 78,905,000 54,106,000 8,035,000 14,628,000 -4,507,000 40,165,000 111,492,000 -7,605,000 36,825,000 31,701,000 -94,683,000 115,855,000 -130,050,450 
      benefit for deferred income taxes
    		                                   23,000           
      supplemental disclosures of non-cash information related to investing and financing activities
    		                                              
      amortization of premiums and accretion of discounts on investments
    		                            -124,000                  
      net cash (used in) / provided by investing activities
    		                                              
      acquisition, including transaction costs
    		                               0 -739,000              
      debt issuance costs related to convertible notes
    		                                              
      change in unrealized gain on marketable securities
    		                                      658,000  -224,000 125,000  10,000 10,000  
      depreciation
    		                                  612,000 813,000 813,000 815,000 849,000 760,000 685,000 634,000 543,000 562,000 588,000 588,556 
      payments on long-term debt
    		                                              
      receivables
    		                                         1,267,000     
      sales & redemptions of marketable securities
    		                                              
      net cash provided by/(used in) investing activities
    		                                       -6,284,000       
      change in unrealized loss on marketable securities
    		                                             -39,695 
      net (decrease)/increase in cash and cash equivalents
    		                                              
      net cash provided/(used in) investing activities
    		                                         20,607,000     
      net increase/(decrease) in cash and cash equivalents
    		                                              
      grant and collaboration receivables
    		                                           -20,000 120,000 86,790 
      net proceeds from sale of series four convertible preferred stock
    		                                             0 
      change in carry value of preferred securities resulting from recapitalization
    		                                             0 
      maturities of marketable securities
    		                                           31,806,000 21,273,000 6,487,191 
      ipo closing costs included in accounts payable and accrued expenses
    		                                              
      net proceeds from secondary offering
    		                                            118,183,000  
      net proceeds from sale of series one convertible preferred stock
    		                                              
      net proceeds from initial public offering
    		                                             -70,629 
      noncash interest expense
    		                                              
      supplemental disclosures of noncash information related to investing and financing activities
    		                                              
    The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.