Pacira BioSciences, Inc
(NASDAQ:PCRX)

Pacira BioSciences, Inc. provides non-opioid pain management and regenerative health solutions for health care practitioners and their patients in the United States. The company develops products based on its proprietary DepoFoam product delivery technology that encapsulates drugs without altering t...

Website: http://www.pacira.com

Founded: 2006

Full Time Employees: 606

Sector: Healthcare

Industry: Drug Manufacturers-Specialty & Generic

Pharmaceuticals

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At a glance:

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Quarterly

Annual

Unit: USD	2026-03-31	2025-12-31	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-12-31	2014-09-30	2014-06-30	2014-03-31	2013-12-31	2013-09-30	2013-06-30	2013-03-31	2012-09-30	2012-06-30	2012-03-31	2011-12-31	2011-09-30	2011-06-30	2011-03-31	2010-12-31

revenues:
net product sales	177,376,000	196,873,000	178,040,000	180,347,000	167,594,000	187,253,000	167,722,000	176,387,000	165,824,000	179,764,000	163,583,000	169,467,000	159,431,000	171,587,000	166,560,000	168,581,000	157,422,000	158,574,000	126,791,000	134,863,000	118,738,000	129,764,000	116,889,000	75,216,000	104,745,000	121,846,000	104,350,000	101,824,000	90,906,000	94,714,000	82,708,000	80,717,000	74,287,000	78,827,000	66,951,000	70,139,000	68,425,000	71,764,000	66,119,000	67,687,000	64,502,000	68,190,000	61,150,000	58,062,000	57,086,000	60,829,000	50,920,000	46,034,000	35,742,000	32,436,000	22,408,000	16,278,000	10,835,000	4,550,000	4,981,000
royalty revenue			1,476,000	752,000	1,329,000		851,000	1,636,000	1,293,000	1,480,000	343,000		910,000	368,000	906,000	830,000	569,000	620,000	931,000	602,000	289,000	1,210,000	595,000	289,000	939,000	578,000	335,000	780,000	407,000	400,000	740,000	390,000	320,000	225,000	358,000	665,000	652,000	781,000	879,000	597,000	616,000	774,000	706,000	730,000	874,000	606,000	771,000	809,000	668,000	886,000	608,000	620,000	509,000	452,000	763,000
total revenues	177,376,000	196,873,000	179,516,000	181,099,000	168,923,000	187,253,000	168,573,000	178,023,000	167,117,000	181,244,000	163,926,000	169,467,000	160,341,000	171,955,000	167,466,000	169,411,000	157,991,000	159,194,000	127,722,000	135,590,000	119,027,000	130,974,000	117,484,000	75,505,000	105,684,000	122,424,000	104,685,000	102,604,000	91,313,000	95,114,000	83,448,000	84,107,000	74,607,000	79,078,000	67,335,000	70,934,000	69,283,000	72,902,000	68,355,000	69,640,000	65,474,000	69,321,000	62,213,000	59,148,000	58,316,000	61,792,000	52,048,000	47,165,000	36,662,000	33,565,000	23,259,000	17,141,000	11,587,000	8,486,000	12,344,000	7,804,000	4,233,000	3,956,000	3,636,000	3,863,000
yoy	5.00%	5.14%	6.49%	1.73%	1.08%	3.32%	2.83%	5.05%	4.23%	5.40%	-2.11%	0.03%	1.49%	8.02%	31.12%	24.94%	32.74%	21.55%	8.71%	79.58%	12.63%	6.98%	12.23%	-26.41%	15.74%	28.71%	25.45%	21.99%	22.39%	20.28%	23.93%	18.57%	7.68%	8.47%	-1.49%	1.86%	5.82%	5.17%	9.87%	17.74%	12.27%	12.18%	19.53%	25.41%	59.06%	84.10%	123.78%	175.16%	216.41%	295.53%	88.42%	119.64%	173.73%	114.51%	239.49%	102.02%
qoq	-9.90%	9.67%	-0.87%	7.21%	-9.79%	11.08%	-5.31%	6.53%	-7.79%	10.56%	-3.27%	5.69%	-6.75%	2.68%	-1.15%	7.23%	-0.76%	24.64%	-5.80%	13.92%	-9.12%	11.48%	55.60%	-28.56%	-13.67%	16.95%	2.03%	12.37%	-4.00%	13.98%	-0.78%	12.73%	-5.65%	17.44%	-5.07%	2.38%	-4.96%	6.65%	-1.85%	6.36%	-5.55%	11.43%	5.18%	1.43%	-5.63%	18.72%	10.35%	28.65%	9.23%	44.31%	35.69%	47.93%	36.54%	-31.25%	58.18%	84.36%	7.00%	8.80%	-5.88%
operating expenses:
cost of goods sold	36,413,000	40,299,000	34,278,000	40,866,000	34,306,000	39,886,000	38,864,000	44,262,000	47,416,000	47,692,000	39,750,000	48,207,000	49,020,000	61,916,000	50,678,000	50,627,000	36,074,000	39,007,000	34,651,000	35,248,000	31,349,000	35,297,000	29,993,000	22,305,000	29,732,000	31,903,000	22,304,000	25,201,000	27,303,000	23,979,000	19,065,000	20,916,000	22,885,000	21,294,000	18,228,000	23,811,000	24,581,000	23,621,000	43,152,000	23,053,000	20,278,000	19,428,000	15,901,000	18,929,000	17,580,000	14,618,000	20,391,000	19,954,000
research and development	28,072,000	37,453,000	25,966,000	28,200,000	25,342,000	23,897,000	19,104,000	20,338,000	18,238,000	19,463,000	20,830,000	18,824,000	17,140,000	17,505,000	19,405,000	26,282,000	21,605,000	15,514,000	11,578,000	12,573,000	15,879,000	15,331,000	14,651,000	13,620,000	15,819,000	19,653,000	20,255,000	17,827,000	14,384,000	14,174,000	14,897,000	12,239,000	14,378,000	10,028,000	11,775,000	18,856,000	16,632,000	17,069,000	9,754,000	9,362,000	9,493,000	13,153,000	5,893,000	3,649,000	5,967,000	3,887,000	4,425,000	5,216,000	5,204,000	4,836,000	5,962,000	4,857,000	5,905,000	3,527,000	1,872,000	1,294,000	2,636,000	4,344,000	4,381,000	3,513,000
selling, general and administrative	93,944,000	101,608,000	91,797,000	88,578,000	86,776,000	79,614,000	74,333,000	68,126,000	72,026,000	65,801,000	67,947,000	64,850,000	70,843,000	63,970,000	61,283,000	65,003,000	64,260,000	51,203,000	48,807,000	50,813,000	48,522,000	52,833,000	52,561,000	43,342,000	44,780,000	54,223,000	50,128,000	49,126,000	48,518,000	44,646,000	44,179,000	44,249,000	44,191,000	39,178,000	40,644,000	39,552,000	42,120,000	34,673,000	36,314,000	43,669,000	37,957,000	37,553,000	35,310,000	34,752,000	31,428,000	31,019,000	28,217,000	24,837,000	22,589,000	20,172,000	15,320,000	14,080,000	12,936,000	11,378,000	10,413,000	11,152,000	6,694,000	4,988,000	4,671,000	3,805,000
amortization of acquired intangible assets	14,322,000	14,322,000	14,322,000	14,322,000	14,322,000	14,322,000	14,322,000	14,322,000	14,322,000	14,322,000	14,322,000	14,322,000	14,322,000	14,322,000	14,322,000	14,322,000	14,322,000	7,653,000	1,967,000	1,967,000	1,967,000	1,966,000	1,967,000	1,967,000	1,967,000	1,967,000	1,967,000	1,770,000
other operating (gains) expenses	-2,277,000
total operating expenses	170,474,000	194,533,000	173,154,000	172,600,000	166,933,000	162,549,000	308,100,000	149,783,000	153,905,000	148,076,000	146,205,000	129,590,000	163,432,000	181,848,000	146,177,000	138,176,000	140,598,000	154,983,000	96,289,000	100,747,000	99,590,000	112,192,000	99,864,000	82,652,000	88,590,000	120,710,000	102,272,000	97,329,000	90,234,000	82,852,000	79,400,000	77,566,000	81,544,000	70,614,000	70,907,000	86,714,000	83,333,000	75,363,000	89,220,000	76,084,000	67,728,000	70,134,000	57,104,000	57,330,000	54,975,000	53,874,000	53,033,000	50,007,000	45,920,000	43,384,000	36,073,000	29,151,000	30,232,000	24,192,000	18,970,000	18,941,000	18,950,000	12,689,000	12,167,000	10,985,000
income from operations	6,902,000	2,340,000	6,362,000	8,499,000	1,990,000	24,704,000	-139,527,000	28,240,000	13,212,000	33,168,000	17,721,000	39,877,000	-3,091,000	-9,893,000	21,289,000	31,235,000	17,393,000	4,211,000	31,433,000	34,843,000	19,437,000	18,782,000	17,620,000	-7,147,000	17,094,000	1,714,000	2,413,000	5,275,000	1,079,000	12,262,000	4,048,000	6,541,000	-6,937,000	8,464,000	-3,572,000	-15,780,000	-14,050,000	-2,461,000	-20,865,000	-6,444,000	-2,254,000	-813,000	5,109,000	1,818,000	3,341,000	7,918,000	-985,000	-2,842,000	-9,258,000	-9,819,000	-12,814,000								-8,531,000	-7,122,000
yoy	246.83%	-90.53%	-104.56%	-69.90%	-84.94%	-25.52%	-887.35%	-29.18%	-527.43%	-435.27%	-16.76%	27.67%	-117.77%	-334.93%	-32.27%	-10.36%	-10.52%	-77.58%	78.39%	-587.52%	13.71%	995.80%	630.21%	-235.49%	1484.24%	-86.02%	-40.39%	-19.35%	-115.55%	44.87%	-213.33%	-141.45%	-50.63%	-443.93%	-82.88%	144.88%	523.34%	202.71%	-508.40%	-454.46%	-167.46%	-110.27%	-618.68%	-163.97%	-136.09%	-180.64%	-92.31%
qoq	194.96%	-63.22%	-25.14%	327.09%	-91.94%	-117.71%	-594.08%	113.75%	-60.17%	87.17%	-55.56%	-1390.10%	-68.76%	-146.47%	-31.84%	79.58%	313.04%	-86.60%	-9.79%	79.26%	3.49%	6.59%	-346.54%	-141.81%	897.32%	-28.97%	-54.26%	388.88%	-91.20%	202.92%	-38.11%	-194.29%	-181.96%	-336.95%	-77.36%	12.31%	470.91%	-88.21%	223.79%	185.89%	177.24%	-115.91%	181.02%	-45.59%	-57.81%	-903.86%	-65.34%	-69.30%	-5.71%	-23.37%									19.78%
operating margin %	3.89%	1.19%	3.54%	4.69%	1.18%	13.19%	-82.77%	15.86%	7.91%	18.30%	10.81%	23.53%	-1.93%	-5.75%	12.71%	18.44%	11.01%	2.65%	24.61%	25.70%	16.33%	14.34%	15.00%	-9.47%	16.17%	1.40%	2.31%	5.14%	1.18%	12.89%	4.85%	7.78%	-9.30%	10.70%	-5.30%	-22.25%	-20.28%	-3.38%	-30.52%	-9.25%	-3.44%	-1.17%	8.21%	3.07%	5.73%	12.81%	-1.89%	-6.03%	-25.25%	-29.25%	-55.09%	0%	0%	0%	0%	0%	0%	0%	-234.63%	-184.36%
other income:
interest income	1,930,000	2,295,000	8,534,000	5,008,000	6,895,000	5,555,000	5,482,000	4,749,000	3,903,000	3,425,000	2,766,000	2,111,000	3,142,000	2,785,000	1,234,000	252,000	271,000	80,000	177,000	224,000	415,000	693,000	1,025,000	1,323,000	1,589,000	1,667,000	1,736,000	1,817,000	2,156,000	2,004,000	1,586,000	1,533,000	1,374,000	1,273,000	1,068,000	1,224,000	514,000	400,000	346,000	324,000	252,000	174,000	171,000	177,000	155,000	145,000	134,000	61,000	42,000	52,000	62,000	72,000	73,000	87,000	68,000	63,000	144,000	46,000	37,000	29,000
interest expense	-3,699,000	-3,892,000	-4,279,000	-4,695,000	-4,580,000	-4,680,000	-4,689,000	-3,884,000	-3,316,000	-3,388,000	-3,464,000	-3,865,000	-9,589,000	-11,041,000	-9,856,000	-8,833,000	-10,246,000	-10,423,000	-7,333,000	-7,023,000	-6,971,000	-7,062,000	-7,132,000	-5,456,000	-6,022,000	-5,997,000	-5,940,000	-5,878,000	-5,814,000	-5,754,000	-5,642,000	-5,397,000	-5,157,000	-5,105,000	-5,127,000	-5,226,000	-2,589,000	-1,858,000	-1,601,000	-1,733,000	-1,868,000	-1,883,000	-1,905,000	-1,940,000	-1,996,000	-2,056,000	-2,037,000	-2,079,000	-2,107,000	-1,928,000	-1,892,000								-676,000	-2,481,000
other	-135,000	-172,000	-110,000	-10,739,000	4,401,000	-53,000	-122,000	-39,000	-159,000	515,000	-422,000	-269,000	-10,000	81,000	-10,598,000	-647,000	-124,000	-66,000	-46,000	-2,396,000	-157,000	281,000	2,708,000	3,969,000	-4,104,000	-925,000	-4,025,000	-87,000	61,000	-189,000	-694,000	-78,000	75,000	-2,000	79,000	80,000	10,000	-74,000	-8,000	-47,000	48,000	-83,000	-8,000	43,000	-117,000	-39,000	-43,000	-41,000	-34,000	-17,000	-8,000						10,000		-22,000	110,000
total other income	-1,904,000	-1,769,000	3,162,000	-10,426,000	6,716,000	822,000	671,000	8,344,000	428,000
income before income taxes	4,998,000	571,000	9,524,000	-1,927,000	8,706,000	25,526,000	-138,856,000	36,584,000	13,640,000	33,720,000	16,601,000	37,854,000	-26,474,000	-18,068,000	2,069,000	22,007,000	7,294,000	-6,198,000	24,231,000	25,648,000	12,724,000	12,694,000	6,150,000	-7,311,000	8,557,000	-3,541,000	-5,816,000	1,127,000	-2,518,000	8,323,000	-702,000	2,599,000	-10,645,000	4,630,000	-7,552,000	-19,713,000	-19,836,000	-3,993,000	-22,128,000	-7,900,000	-3,822,000	-2,606,000	3,367,000	47,000	1,312,000	5,975,000	-3,004,000	-5,037,000	-11,477,000	-11,956,000	-14,784,000
income tax expense	-2,082,000	1,066,000	-4,092,000	-2,920,000	-3,894,000	-6,742,250	-4,610,000	-17,698,000		-2,724,000	-5,743,000	-12,091,000		-1,339,750	-2,762,000	-2,131,000	-466,000				-2,355,000				-398,000				-253,000			-35,000	-35,000	-35,000	-45,000	-30,000	-30,000	21,000	-36,000	-58,000	-32,000	-93,000	-281,000	-39,000	-52,000
net income	2,916,000	1,637,000	5,432,000	-4,847,000	4,812,000	16,041,000	-143,466,000	18,886,000	8,979,000	24,870,000	10,858,000	25,763,000	-19,536,000	-10,102,000	-693,000	19,876,000	6,828,000	-5,130,000	17,660,000	19,081,000	10,369,000	14,515,000	130,119,000	-7,269,000	8,159,000	-4,888,000	-6,087,000	2,730,000	-2,771,000	8,285,000	-640,000	2,564,000	-10,680,000	4,595,000	-7,597,000	-19,743,000	-19,866,000	-3,972,000	-22,164,000	-7,958,000	-3,854,000	-2,498,000	3,086,000	8,000	1,260,000	5,802,000	-3,004,000	-5,037,000	-11,477,000	-11,956,000	-14,784,000	-14,031,000	-23,138,000	-15,745,000	-8,296,000	-11,894,000	-15,283,000	-9,508,000	-8,763,000	-9,775,000
yoy	-39.40%	-89.79%	-103.79%	-125.66%	-46.41%	-35.50%	-1421.29%	-26.69%	-145.96%	-346.19%	-1666.81%	29.62%	-386.12%	96.92%	-103.92%	4.17%	-34.15%	-135.34%	-86.43%	-362.50%	27.09%	-396.95%	-2237.65%	-366.26%	-394.44%	-159.00%	851.09%	6.47%	-74.05%	80.30%	-91.58%	-112.99%	-46.24%	-215.68%	-65.72%	148.09%	415.46%	59.01%	-818.21%	-99575.00%	-405.87%	-143.05%	-202.73%	-100.16%	-110.98%	-148.53%	-79.68%	-64.10%	-50.40%	-24.06%	78.21%	17.97%	51.40%	65.60%	-5.33%	21.68%
qoq	78.13%	-69.86%	-212.07%	-200.73%	-70.00%	-111.18%	-859.64%	110.34%	-63.90%	129.05%	-57.85%	-231.87%	93.39%	1357.72%	-103.49%	191.10%	-233.10%	-129.05%	-7.45%	84.02%	-28.56%	-88.84%	-1890.05%	-189.09%	-266.92%	-19.70%	-322.97%	-198.52%	-133.45%	-1394.53%	-124.96%	-124.01%	-332.43%	-160.48%	-61.52%	-0.62%	400.15%	-82.08%	178.51%	106.49%	54.28%	-180.95%	38475.00%	-99.37%	-78.28%	-293.14%	-40.36%	-56.11%	-4.01%	-19.13%	5.37%	-39.36%	46.95%	89.79%	-30.25%	-22.17%	60.74%	8.50%	-10.35%
net income margin %	1.64%	0.83%	3.03%	-2.68%	2.85%	8.57%	-85.11%	10.61%	5.37%	13.72%	6.62%	15.20%	-12.18%	-5.87%	-0.41%	11.73%	4.32%	-3.22%	13.83%	14.07%	8.71%	11.08%	110.75%	-9.63%	7.72%	-3.99%	-5.81%	2.66%	-3.03%	8.71%	-0.77%	3.05%	-14.32%	5.81%	-11.28%	-27.83%	-28.67%	-5.45%	-32.42%	-11.43%	-5.89%	-3.60%	4.96%	0.01%	2.16%	9.39%	-5.77%	-10.68%	-31.30%	-35.62%	-63.56%	-81.86%	-199.69%	-185.54%	-67.21%	-152.41%	-361.04%	-240.34%	-241.01%	-253.04%
net income per common share:
basic and diluted net income per common share	70	30	120		100	-625	-3,110		0.19																0.19							0.06								-0.21	-0.1				0.03
weighted-average common shares outstanding:
basic	40,461,000	44,566	44,038,000	45,459,000	46,275,000	46,245	46,134,000	46,174	46,499	46,222	46,416	46,088	45,949	45,521	45,831	45,501	44,869	44,262	44,476	44,145	43,833	42,671	42,928	42,221	42,032			41,384				40,796		39,806				37,236	37,312	37,181	37,020	36,540	36,663	36,481	36,235
diluted	40,910,000	45,042	44,459,000	45,459,000	46,526,000	46,245	46,134,000	50,539	52,193	51,979	52,067	52,054	45,949	46,538	45,831	52,478	46,438	45,630	45,463	45,592	45,966	43,682	44,275	42,221	42,785			42,345				41,694		39,806				37,236	37,312	37,181	37,020	41,301	41,043	41,445	41,779
goodwill impairment							163,243,000
contingent consideration charges (gains), acquisition-related expenses, restructuring and other		3,315,250	6,791,000
gain on early extinguishment of debt			-983,000					7,518,000
contingent consideration (gains) charges, acquisition-related expenses, restructuring and other				634,000
basic net income per common share				-110				0.41		0.54	0.23	0.56	-0.43	-0.22	-0.02	0.44	0.15	-0.12	0.4	0.43	0.24	0.32	3.03	-0.17				0.07										-0.11	-0.59			-0.07	0.08
diluted net income per common share				-110				0.39		0.52	0.23	0.51	-0.43	-0.22	-0.02	0.4	0.15	-0.11	0.39	0.42	0.23	0.31	2.94	-0.17				0.06										-0.11	-0.59			-0.07	0.08
contingent consideration gains, acquisition-related expenses, restructuring and other					6,187,000
contingent consideration (gains) charges, restructuring charges and other						718,000	-1,766,000		1,903,000
contingent consideration charges (gains), restructuring charges and other								2,735,000		-287,500	3,356,000
net income per share
loss on early extinguishment of debt													-16,926,000										-8,071,000													-11,000	-3,721,000
income tax benefit									-4,661,000				6,938,000					1,068,000	-6,571,000	-6,567,000		1,821,000	123,969,000	42,000		269,750	-271,000	1,603,000		-2,000	62,000																						442,000
total other expense										552,000	-1,120,000	-2,023,000	-23,383,000	-8,175,000	-19,220,000	-9,228,000	-10,099,000	-10,409,000	-7,202,000	-9,195,000	-6,713,000	-6,088,000	-11,470,000	-164,000	-8,537,000	-5,255,000	-8,229,000	-4,148,000	-3,597,000	-3,939,000	-4,750,000	-3,942,000	-3,708,000	-3,834,000	-3,980,000	-3,933,000	-5,786,000	-1,532,000	-1,263,000	-1,456,000	-1,568,000	-1,793,000	-1,742,000	-1,771,000	-2,029,000	-1,943,000	-2,019,000	-2,195,000	-2,219,000	-2,137,000	-1,970,000								-232,000	-2,653,000
acquisition-related (gains) charges, restructuring charges and other												-16,613,000
acquisition-related charges (gains) and other													12,107,000	-3,308,000	489,000
collaborative licensing and milestone revenue																				125,000												3,000,000		26,000	26,000	130,000	206,000	357,000	1,357,000	1,356,000	356,000
acquisition-related (gains) charges, product discontinuation and other																-18,058,000		326,250	-714,000
acquisition-related charges, product discontinuation and other																	4,337,000
acquisition-related charges (gains), product discontinuation and other																				146,000
acquisition-related loss (gains), product discontinuation and other																					1,873,000
acquisition-related charges (gains) and product discontinuation																						-399,750	692,000	1,418,000
acquisition-related (gains) charges and product discontinuation																									-3,708,000
acquisition-related charges and product discontinuation																										3,066,500	7,618,000	3,405,000
basic and diluted net loss per common share																										-0.12	-0.15		-0.07	0.2	-0.02		-0.26	-0.298	-0.19	-0.49	-0.52									0.17	-0.08	-0.14	-0.34	-0.36	-0.44	-0.42	-0.71	-0.49	-0.27	-0.47	-0.75	-0.55	-0.51	-0.98
weighted-average common shares outstanding:
basic and diluted																										41,513	41,645		41,240	40,911	40,995		40,707		40,463	40,160	37,998									35,299	35,943	35,463	33,710,970	33,181,895	33,359,576	33,083,289	32,709,298	32,436,207	30,953,635	25,367,306	16,437,464	17,230,826	17,233,146	10,014,042
product discontinuation																													29,000	53,000	1,259,000	162,000	90,000	114,000	260,000	4,495,000
royalty interest obligation																																													-71,000	7,000	-73,000	-136,000	-120,000	-244,000	-132,000			378,000			-8,000	116,000	429,000	-311,000
collaborative licensing and development revenue																																										267,250	357,000	356,000	356,000	357,000	357,000	322,000	252,000	243,000	243,000	243,000	243,000	3,484,000	6,600,000	6,490,000	1,229,000	1,352,000	1,283,000	1,210,000
loss on extinguishment of debt																																										-12,750		-51,000
cost of revenues																																																	18,127,000	18,376,000	14,791,000	10,214,000	11,391,000	9,287,000	6,685,000	6,495,000	6,601,000	3,357,000	3,115,000	3,667,000
supply and royalty revenue																																																								1,314,000
supply revenue																																																									1,217,000	1,682,000	1,469,000	1,716,000
royalties																																																									685,750	922,000	884,000	937,000
total other (expense)

Balance Sheets:

Quarterly

Annual

Unit: USD	2026-03-31	2025-12-31	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-12-31	2014-09-30	2014-06-30	2014-03-31	2013-12-31	2013-09-30	2013-06-30	2013-03-31	2012-09-30	2012-06-30	2012-03-31	2011-12-31	2011-09-30	2011-06-30	2011-03-31	2010-12-31

assets
current assets:
cash and cash equivalents	144,306,000	158,545,000	147,589,000	300,484,000	283,610,000	276,774,000	245,965,000	247,053,000	184,052,000	153,298,000	99,119,000	86,810,000	35,545,000	104,139,000	109,424,000	122,061,000	226,751,000	585,578,000	134,036,000	105,774,000	66,699,000	99,957,000	125,244,000	78,552,000	54,589,000	78,228,000	85,139,000	59,737,000	215,036,000	132,526,000	230,941,000	116,871,000	41,563,000	54,126,000	26,216,000	53,814,000	108,970,000	35,944,000	24,442,000	25,309,000	35,029,000	56,984,000	30,522,000	32,722,000	40,897,000	37,520,000	17,756,000	108,200,000	18,762,000	12,515,000	3,383,000	8,626,000	26,272,000	8,709,000	21,445,000	25,213,000	46,168,000	16,402,000	27,450,000	59,331,000	26,133,000
short-term available-for-sale investments	57,874,000	79,879,000	98,745,000	145,380,000	210,016,000	207,841,000	207,845,000	157,173,000	141,838,000	125,283,000	136,069,000	133,956,000	138,454,000	184,512,000	219,301,000	194,332,000	225,443,000	70,831,000	559,822,000
accounts receivable	125,635,000	124,069,000	115,268,000	114,367,000	104,745,000	113,304,000	100,653,000	104,779,000	101,639,000	105,556,000	96,956,000	99,079,000	93,205,000	98,397,000	93,471,000	91,105,000	92,103,000	96,318,000	49,975,000	68,357,000	52,583,000	53,046,000	46,143,000	44,013,000	38,988,000	47,530,000	42,573,000	41,147,000	39,766,000	38,000,000	34,266,000	35,641,000	31,203,000	31,658,000	27,021,000	27,467,000	27,702,000	29,937,000	26,765,000	28,651,000	25,901,000	25,855,000	25,919,000	24,281,000	24,511,000	22,366,000	20,517,000	20,545,000	15,969,000	14,590,000	9,771,000	7,756,000	5,243,000	2,459,000	3,214,000
inventories	150,370,000	152,863,000	157,680,000	148,163,000	133,754,000	125,282,000	111,865,000	103,438,000	96,782,000	104,353,000	96,520,000	92,130,000	92,977,000	96,063,000	96,799,000	100,588,000	103,662,000	98,550,000	67,209,000	65,264,000	64,606,000	64,650,000	68,542,000	66,690,000	59,666,000	58,296,000	60,238,000	52,697,000	47,028,000	48,569,000	44,884,000	42,053,000	40,043,000	41,411,000	39,112,000	33,602,000	30,311,000	31,278,000	37,476,000	60,916,000	63,744,000	61,645,000	56,132,000	48,769,000	36,264,000	29,263,000	23,662,000	19,194,000	15,364,000	15,557,000	15,606,000	14,221,000	10,760,000	11,906,000	9,299,000	5,078,000	1,245,000	1,667,000	1,884,000	1,778,000	1,605,000
prepaid expenses and other current assets	36,776,000	32,618,000	43,469,000	37,219,000	27,837,000	21,929,000	23,641,000	19,771,000	18,802,000	21,504,000	18,591,000	17,349,000	15,933,000	15,223,000	14,416,000	18,124,000	19,059,000	14,771,000	11,310,000	12,363,000	12,995,000	12,265,000	11,710,000	18,328,000	14,476,000	10,781,000	10,392,000	8,526,000	9,437,000	7,946,000	6,490,000	6,039,000	7,700,000	6,694,000	5,622,000	7,480,000	6,252,000	9,277,000	10,075,000	5,755,000	8,959,000	6,117,000	4,611,000	3,429,000	4,089,000	4,461,000	3,504,000	3,139,000	2,572,000	2,819,000	2,486,000	2,559,000	2,740,000	2,024,000	1,431,000	1,496,000	1,839,000	1,482,000	1,391,000	1,107,000	812,000
total current assets	514,961,000	547,974,000	562,751,000	745,613,000	759,962,000	745,130,000	689,969,000	632,214,000	543,113,000	509,994,000	447,255,000	429,324,000	376,114,000	498,334,000	533,411,000	526,210,000	667,018,000	866,048,000	822,352,000	792,579,000	720,247,000	651,623,000	658,520,000	455,823,000	431,594,000	408,557,000	378,847,000	394,609,000	508,673,000	477,969,000	472,049,000	455,054,000	418,734,000	391,110,000	365,835,000	450,991,000	447,964,000	243,089,000	235,444,000	257,989,000	248,625,000	252,582,000	233,100,000	229,626,000	219,750,000	214,257,000	199,240,000	208,906,000	98,478,000	106,751,000	111,685,000	121,490,000	128,989,000	85,129,000	100,076,000	62,264,000	82,649,000	43,400,000	53,604,000	64,026,000	31,055,000
fixed assets	136,281,000	140,690,000	147,388,000	155,178,000	164,451,000	167,169,000	166,852,000	168,850,000	171,804,000	173,927,000	175,783,000	180,310,000	181,617,000	183,512,000	193,646,000	191,279,000	189,767,000	188,401,000	159,235,000	153,302,000	144,822,000	136,688,000	125,527,000	113,297,000	108,105,000	104,681,000	104,856,000	105,492,000	107,051,000	108,670,000	110,063,000	111,276,000	109,225,000	107,046,000	105,947,000	103,239,000	102,571,000	101,016,000	100,388,000	99,282,000	95,846,000	90,324,000	86,323,000	77,809,000	67,206,000	60,632,000	56,148,000	53,513,000	49,891,000	48,182,000	45,944,000	42,065,000	41,130,000	35,319,000	29,966,000	26,492,000	25,103,000	25,825,000	24,633,000	24,359,000	23,950,000
right-of-use assets	39,409,000	41,777,000	44,266,000	46,528,000	48,728,000	49,222,000	53,830,000	56,264,000	58,626,000	61,020,000	63,394,000	65,837,000	68,084,000	70,877,000	69,662,000	72,082,000	74,271,000	76,410,000	69,790,000	71,252,000	72,888,000	74,492,000	76,047,000	77,799,000	37,613,000	38,124,000	35,756,000	36,494,000	26,686,000
goodwill	19,773,000	20,214,000	20,317,000	20,300,000	21,520,000			163,243,000	163,243,000	163,243,000	163,243,000	163,243,000	163,243,000	163,243,000	157,361,000	146,132,000	145,722,000	145,175,000	99,547,000	99,547,000	99,547,000	99,547,000	99,547,000	99,547,000	99,547,000	99,547,000	99,547,000	100,538,000	62,040,000	62,040,000	62,040,000	59,912,000	57,490,000	55,197,000	52,956,000	50,943,000	48,829,000	46,737,000	44,670,000	42,751,000	32,784,000	30,880,000	28,888,000	27,123,000	25,381,000	23,761,000	22,048,000	12,520,000	11,327,000	10,328,000	9,539,000	8,980,000	8,582,000	8,109,000	7,992,000
intangible assets	353,227,000	368,100,000	382,396,000	422,563,000	434,969,000	425,970,000	440,292,000	454,614,000	468,936,000	483,258,000	497,580,000	511,902,000	526,224,000	540,546,000	581,002,000	595,324,000	609,646,000	623,968,000	90,621,000	92,588,000	94,554,000	96,521,000	98,487,000	100,454,000	102,421,000	104,387,000	106,354,000	108,320,000
deferred tax assets	122,115,000	123,854,000	120,188,000	128,270,000	129,008,000	130,376,000	134,022,000	135,136,000	141,057,000	144,485,000	151,660,000	156,140,000	167,570,000	160,309,000	155,531,000	167,149,000	169,282,000	153,364,000	93,265,000	98,599,000	104,467,000	106,164,000	104,122,000
investments and other assets	22,768,000	22,308,000	20,271,000	18,810,000	28,031,000	35,649,000	36,726,000	36,499,000	36,542,000	36,049,000	35,547,000	35,625,000	32,285,000	27,170,000	26,358,000	35,812,000	35,770,000	21,987,000	21,192,000
total assets	1,208,534,000	1,264,917,000	1,297,577,000	1,537,262,000	1,586,669,000	1,553,516,000	1,521,691,000	1,646,820,000	1,583,321,000	1,574,386,000	1,534,462,000	1,542,381,000	1,523,418,000	1,681,200,000	1,734,365,000	1,733,988,000	1,891,476,000	2,075,353,000	1,356,002,000	1,325,833,000	1,287,549,000	1,274,513,000	1,220,269,000	866,111,000	821,379,000	831,065,000	807,489,000	787,843,000	719,156,000	689,353,000	659,045,000	642,681,000	622,037,000	628,371,000	606,090,000	605,745,000	599,962,000	391,466,000	381,153,000	400,699,000	391,206,000	389,623,000	368,988,000	354,993,000	335,030,000	326,072,000	305,394,000	292,080,000	163,693,000	169,820,000	172,395,000	178,430,000	185,241,000	132,826,000	142,853,000	94,264,000	113,490,000	77,609,000	87,092,000	97,869,000	66,562,000
liabilities and stockholders’ equity
current liabilities:
accounts payable	14,012,000	15,150,000	17,687,000	30,124,000	23,172,000	19,133,000	19,367,000	18,730,000	8,982,000	15,698,000	16,511,000	24,206,000	17,261,000	15,220,000	12,933,000	13,983,000	14,843,000	10,543,000	7,895,000	12,179,000	9,110,000	10,431,000	13,008,000	9,160,000	15,850,000	12,799,000	16,064,000	13,347,000	13,369,000	14,368,000	13,795,000	14,260,000	14,913,000	14,658,000	12,278,000	10,392,000	9,373,000	7,511,000	7,287,000	4,614,000	10,484,000	8,739,000	8,471,000	13,299,000	5,565,000	6,758,000	7,747,000	3,145,000	2,605,000	3,069,000	1,559,000	1,712,000	1,001,000	4,789,000	440,000	2,302,000	3,440,000	4,313,000	5,052,000	6,097,000	6,038,000
accrued expenses	84,957,000	95,601,000	79,643,000	71,023,000	80,069,000	80,124,000	76,377,000	64,811,000	66,818,000	64,243,000	59,884,000	56,221,000	61,633,000	89,785,000	76,357,000	77,275,000	87,669,000	127,555,000	50,798,000	52,163,000	50,239,000	70,974,000	60,403,000	47,684,000	44,717,000	70,427,000	61,002,000	51,907,000	39,696,000	45,865,000				41,057,000	39,701,000	46,755,000	34,900,000	36,666,000	31,077,000	38,330,000	29,067,000	35,375,000	30,295,000	26,790,000	25,296,000	28,450,000	23,383,000	23,035,000	16,913,000	17,885,000	15,573,000	12,260,000	9,872,000	13,036,000	9,279,000	7,040,000	7,159,000	4,998,000	3,641,000	3,830,000	3,260,000
lease liabilities	9,818,000	9,839,000	9,748,000	9,620,000	9,405,000	8,887,000	9,191,000	9,149,000	9,003,000	8,801,000	8,625,000	8,981,000	8,951,000	9,121,000	8,364,000	8,134,000	8,018,000	7,891,000	5,879,000	5,644,000	5,503,000	7,425,000	7,455,000	7,620,000	3,968,000	4,935,000	5,043,000	6,172,000	5,583,000
total current liabilities	108,787,000	120,590,000	107,078,000	313,164,000	314,732,000	309,920,000	306,401,000	92,690,000	93,444,000	97,383,000	93,661,000	108,912,000	98,698,000	147,774,000	131,526,000	133,179,000	305,073,000	521,118,000	225,788,000	228,693,000	232,084,000	253,328,000	86,272,000	70,583,000	80,313,000	107,673,000	95,838,000	83,004,000	58,991,000	60,661,000	54,523,000	53,024,000	48,368,000	56,217,000	52,337,000	57,510,000	45,648,000	44,838,000	146,831,000	150,438,000	146,139,000	151,676,000	145,411,000	145,472,000	136,453,000	140,010,000	135,223,000	129,506,000	121,587,000	121,943,000	116,972,000	15,835,000	12,698,000	19,828,000	15,236,000	19,158,000	31,911,000	17,829,000	17,479,000	19,663,000	16,322,000
long-term debt	367,656,000	372,189,000	376,721,000	97,828,000	101,489,000	104,211,000	107,024,000	109,751,000	112,477,000	115,202,000	117,965,000	134,823,000	137,534,000	251,056,000	309,848,000	318,344,000	326,828,000	335,263,000																																		96,892,000	95,857,000	24,930,000	24,670,000	23,632,000	18,537,000	20,603,000	20,358,000	19,570,000	21,869,000
contingent consideration	15,789,000	18,066,000	17,834,000	17,209,000	17,566,000	20,241,000	19,157,000	22,401,000	20,892,000	24,698,000	24,275,000	21,482,000	39,740,000	28,122,000	34,204,000	35,247,000	56,527,000		5,070,000	5,026,000	14,864,000	14,736,000	5,406,000	4,504,000	14,041,000	18,179,000	13,591,000	11,500,000
deferred tax liabilities	4,093,000	4,213,000	4,587,000	4,583,000	6,996,000
other liabilities	24,611,000	20,572,000	25,304,000	25,153,000	23,866,000	16,817,000	12,784,000	13,005,000	12,690,000	13,573,000	11,945,000	11,783,000	11,579,000	9,669,000	19,112,000	19,473,000	10,722,000	9,847,000	7,553,000	7,697,000	5,288,000	3,832,000	4,219,000	2,984,000	1,535,000	1,502,000	2,320,000	8,993,000	8,993,000	16,874,000	16,363,000	15,886,000	15,463,000	16,498,000	16,232,000	17,859,000	10,332,000	11,427,000	12,557,000	14,163,000	11,020,000	11,473,000	6,125,000	5,447,000	5,404,000	5,409,000	5,235,000	4,384,000	3,435,000	3,190,000	2,911,000	2,743,000	2,694,000	2,399,000	2,538,000	2,675,000	2,778,000	3,571,000	2,292,000
total liabilities	554,641,000	571,806,000	570,363,000	779,495,000	788,128,000	775,168,000	772,108,000	767,542,000	691,159,000	704,256,000	702,911,000	734,406,000	755,377,000	906,190,000	964,242,000	977,352,000	1,181,900,000	1,344,945,000	637,400,000	638,665,000	636,731,000	654,825,000	635,579,000	477,963,000	447,342,000	476,121,000	461,327,000	446,193,000	391,637,000	368,127,000	357,779,000	352,168,000	343,516,000	348,888,000	341,290,000	344,697,000	329,329,000	172,490,000	167,005,000	172,348,000	165,036,000	171,231,000	159,975,000	159,714,000	151,009,000	154,927,000	150,322,000	144,111,000	127,982,000	128,571,000	123,277,000	119,288,000	115,449,000	52,381,000	48,348,000	57,022,000	65,221,000	63,734,000	64,157,000	66,723,000	114,945,000
commitments and contingencies
stockholders’ equity:
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at march 31, 2026 and december 31, 2025
common stock	48,000	48,000	48,000	48,000	47,000	47,000	47,000	47,000	47,000	46,000	46,000	46,000	46,000	46,000	46,000	46,000	45,000	45,000	45,000	44,000	44,000	44,000	43,000	43,000	42,000	42,000	42,000	42,000	41,000	41,000	41,000	41,000	41,000	41,000	41,000	40,000	40,000	37,000	37,000	37,000	37,000	37,000	37,000	37,000	36,000	36,000	36,000	36,000	34,000	34,000	34,000	33,000	33,000				25,000	17,000			1,000
treasury stock	-227,013,000	-176,565,000	-125,543,000	-75,515,000	-25,121,000	-25,121,000	-25,121,000	-25,121,000																																											-2,000								-2,000	-2,000
additional paid-in capital	1,073,809,000	1,064,623,000	1,049,545,000	1,035,563,000	1,023,808,000	1,009,435,000	996,376,000	983,178,000	989,780,000	976,633,000	963,181,000	950,626,000	936,419,000	924,095,000	909,396,000	895,151,000	867,890,000	942,091,000	925,169,000	911,368,000	894,108,000	873,201,000	852,190,000	785,124,000	766,280,000	753,978,000	740,183,000	729,531,000	718,449,000	709,691,000	697,977,000	686,888,000	677,836,000	669,032,000	658,557,000	647,206,000	637,066,000	565,207,000	556,405,000	548,277,000	538,227,000	526,696,000	514,796,000	504,146,000	492,898,000	481,334,000	470,975,000	460,907,000	343,578,000	337,639,000	333,542,000	328,787,000	325,375,000	296,525,000	294,806,000	229,335,000	228,470,000	178,821,000	178,368,000	177,817,000	88,523,000
accumulated deficit	-196,406,000	-199,322,000	-200,959,000	-206,391,000	-201,544,000	-206,356,000	-222,397,000	-78,931,000	-97,817,000	-106,796,000	-131,666,000	-142,524,000	-168,287,000	-148,751,000	-138,649,000	-137,956,000	-157,832,000	-211,895,000	-206,765,000	-224,425,000	-243,506,000	-253,875,000	-268,390,000	-398,509,000	-391,239,000	-399,398,000	-394,510,000	-388,423,000	-391,153,000	-388,226,000	-396,511,000	-395,871,000	-398,455,000	-389,136,000	-393,731,000	-386,134,000	-366,391,000	-346,238,000	-342,266,000	-320,101,000	-312,143,000	-308,289,000	-305,791,000	-308,877,000	-308,885,000	-310,145,000	-315,947,000	-312,943,000	-307,906,000	-296,429,000	-284,473,000								-155,448,000	-146,686,000	-136,911,000
accumulated other comprehensive income	3,455,000	4,327,000	4,123,000	4,062,000	1,351,000	343,000	678,000	105,000	152,000	247,000				-380,000	-670,000	-605,000	-527,000	167,000	153,000	181,000	172,000	318,000	847,000	1,490,000	-1,046,000	322,000	447,000	500,000	182,000											138,000	49,000					-80,000	8,000	-31,000	5,000	5,000	17,000	13,000	44,000	64,000	98,000	17,000	15,000
total stockholders’ equity	653,893,000	693,111,000	727,214,000	757,767,000	798,541,000	778,348,000	749,583,000	879,278,000	892,162,000	870,130,000	831,551,000	807,975,000	768,041,000	775,010,000	770,123,000	756,636,000	709,576,000	730,408,000	718,602,000	687,168,000	650,818,000	619,688,000	584,690,000	388,148,000	374,037,000	354,944,000	346,162,000	341,650,000	327,519,000	321,226,000	301,266,000	290,513,000	278,521,000	279,483,000	264,800,000	261,048,000	270,633,000	218,976,000	214,148,000	228,351,000	226,170,000	218,392,000	209,013,000	195,279,000	184,021,000	171,145,000	155,072,000	147,969,000	35,711,000		49,118,000	59,142,000	69,792,000	80,445,000	94,505,000	37,242,000	48,269,000	13,875,000	22,935,000	31,146,000
total liabilities and stockholders’ equity	1,208,534,000	1,264,917,000	1,297,577,000	1,537,262,000	1,586,669,000	1,553,516,000	1,521,691,000	1,646,820,000	1,583,321,000	1,574,386,000	1,534,462,000	1,542,381,000	1,523,418,000	1,681,200,000	1,734,365,000	1,733,988,000	1,891,476,000	2,075,353,000	1,356,002,000	1,325,833,000	1,287,549,000	1,274,513,000	1,220,269,000	866,111,000	821,379,000	831,065,000	807,489,000	787,843,000	719,156,000	689,353,000	659,045,000	642,681,000	622,037,000	628,371,000	606,090,000	605,745,000	599,962,000	391,466,000	381,153,000	400,699,000	391,206,000	389,623,000	368,988,000	354,993,000	335,030,000	326,072,000	305,394,000	292,080,000	163,693,000		172,395,000	178,430,000	185,241,000	132,826,000	142,853,000	94,264,000	113,490,000	77,609,000	87,092,000	97,869,000
current portion of long-term debt												10,863,000	10,853,000	33,648,000	33,872,000	33,776,000	33,680,000	24,234,000																																						1,364,000	7,039,000	4,871,000	4,869,000	5,568,000	3,182,000
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at december 31, 2025 and 2024
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2025 and december 31, 2024
current portion of convertible senior notes				202,397,000	202,086,000	201,776,000	201,466,000		8,641,000	8,641,000	8,641,000	8,641,000
convertible senior notes				280,267,000	279,801,000	279,334,000	278,867,000	479,549,000	399,210,000	398,594,000	397,976,000	397,360,000	405,384,000				160,000,000	350,466,000	155,751,000	153,681,000	151,647,000	149,648,000	456,464,000	314,182,000	310,078,000					338,000	334,000	330,000	327,000	324,000	320,000	319,000	759,000		107,563,000	106,388,000	105,215,000	105,928,000	104,907,000	103,885,000	104,135,000	103,100,000	102,065,000	101,031,000	99,996,000	98,961,000	97,927,000
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2025 and december 31, 2024
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at march 31, 2025 and december 31, 2024
noncurrent available-for-sale investments										2,410,000			8,281,000	37,209,000	17,394,000
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at december 31, 2024 and 2023
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2024 and december 31, 2023
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2024 and december 31, 2023
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at march 31, 2024 and december 31, 2023
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at december 31, 2023 and 2022
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2023 and december 31, 2022
accumulated other comprehensive loss											-10,000	-173,000	-137,000																	-280,000	-241,000	-545,000	-901,000	-454,000	-67,000	-64,000	-82,000	-30,000	-28,000			-52,000	-29,000	-27,000	-28,000
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2023 and december 31, 2022
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at march 31, 2023 and december 31, 2022
income taxes payable																11,000	863,000	429,000	395,000		721,000	114,000		1,615,000	1,737,000	1,333,000	138,000	78,000	343,000	90,000	35,000		111,000	76,000	38,000	44,000	96,000	66,000	82,000	58,000	98,000	208,000	312,000	72,000	31,000
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at december 31, 2022 and 2021
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2022 and december 31, 2021
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2022 and december 31, 2021
deferred revenue																	10,125,000	10,125,000																			7,357,000	7,487,000	7,617,000	7,747,000	7,877,000	8,082,000	8,439,000	8,795,000	9,152,000	9,508,000	9,864,000	10,221,000	2,960,000	3,212,000	2,991,000	3,234,000	3,477,000	4,343,000	4,634,000	8,073,000	8,416,000	17,847,000	18,414,000	18,855,000
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at march 31, 2022 and december 31, 2021
long-term available-for-sale investments
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at december 31, 2021 and 2020
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2021 and december 31, 2020
short-term investments																				540,821,000	523,364,000	421,705,000	406,881,000	248,240,000	263,875,000	213,722,000	180,505,000	232,502,000	197,406,000	250,928,000	155,468,000	254,450,000	298,225,000	257,221,000	267,864,000	328,628,000	274,729,000	136,653,000	136,686,000	137,358,000	114,992,000	101,981,000	115,916,000	120,425,000	113,989,000	119,138,000	131,972,000	55,660,000	45,811,000	59,637,000	78,464,000	87,330,000	83,974,000	58,240,000	62,840,000	29,617,000	29,985,000	20,666,000	19,755,000
long-term investments																					34,971,000	95,459,000	44,062,000	8,261,000	35,120,000	64,798,000	70,577,000	25,362,000		25,871,000		1,601,000	21,683,000	60,047,000	80,807,000						13,470,000	13,462,000	17,921,000	17,941,000	19,938,000	24,431,000	24,527,000	13,474,000
equity investments and other assets																				17,966,000	16,053,000	14,019,000
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2021 and december 31, 2020
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at march 31, 2021 and december 31, 2020
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at december 31, 2020 and 2019
equity investment and other assets																							13,957,000	10,930,000	6,979,000	10,971,000	11,552,000	17,028,000
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2020 and december 31, 2019
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2020 and december 31, 2019
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at march 31, 2020 and december 31, 2019
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at december 31, 2019 and 2018
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2019 and december 31, 2018
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2019 and december 31, 2018
equity investment																													14,146,000	14,146,000	14,146,000	14,146,000	14,146,000	14,146,000
other assets																													560,000	657,000	747,000	692,000	759,000	825,000	545,000	572,000	598,000	624,000	651,000	677,000	481,000	2,294,000	2,595,000	2,252,000	2,432,000	2,588,000	2,948,000	3,103,000	3,353,000	3,402,000	3,557,000	3,712,000	3,845,000	548,000	586,000	762,000	479,000	1,180,000	1,075,000	1,138,000	2,645,000
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at march 31, 2019 and december 31, 2018
current portion of deferred revenue																																		102,000			520,000	595,000	822,000	1,048,000	1,275,000	1,426,000	1,426,000	1,426,000	1,426,000	1,426,000	1,426,000	1,426,000	1,008,000	1,008,000	972,000	972,000	972,000	1,166,000	4,353,000	7,231,000	13,054,000	2,354,000	2,458,000	2,550,000	2,267,000
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at december 31, 2018 and 2017
accrued expenses and current portion of deferred revenue																															40,359,000	38,434,000	33,017,000
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2018 and december 31, 2017
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2018 and december 31, 2017
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at march 31, 2018 and december 31, 2017
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at december 31, 2017 and 2016
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2017 and december 31, 2016
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2017 and december 31, 2016
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at march 31, 2017 and december 31, 2016
intangibles																																										81,000	161,000	242,000	323,000	403,000	483,000	564,000	644,000	1,157,000	1,670,000	2,183,000	2,695,000	3,721,000	4,233,000	4,746,000	5,259,000	7,204,000	7,780,000	8,346,000	8,912,000
preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at december 31, 2016 and 2015
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2016 and december 31, 2015
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2016 and december 31, 2015
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at march 31, 2016 and december 31, 2015
restricted cash																																														1,509,000	1,829,000	2,168,000		1,633,000	1,975,000	998,000		1,791,000	1,847,000		1,299,000	1,687,000	2,069,000		1,314,000
current portion of royalty interest obligation																																														276,000	602,000	869,000	1,065,000	1,020,000	941,000	891,000	853,000	837,000	1,164,000	1,221,000	1,219,000	1,293,000	1,459,000	1,618,000	1,575,000
preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at december 31, 2015 and 2014
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2015 and december 31, 2014
preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2015 and december 31, 2014
preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at march 31, 2015 and december 31, 2014
royalty interest obligation																																																		226,000	403,000	584,000	723,000	881,000	1,270,000	1,442,000	1,537,000	1,842,000	2,220,000	2,877,000
preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at december 31, 2014 and 2013
preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at september 30, 2014 and december 31, 2013
preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at june 30, 2014 and december 31, 2013
preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at march 31, 2014 and december 31, 2013
liabilities and stockholders' equity
stockholders' equity:
preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at december 31, 2013 and 2012
total stockholders' equity																																																		41,249,000
total liabilities and stockholders' equity																																																		169,820,000
preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at september 30, 2013 and december 31, 2012
preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at june 30, 2013 and december 31, 2012
preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at march 31, 2013 and december 31, 2012
contingent purchase liability																																																								2,042,000	2,042,000	2,042,000	2,042,000	2,042,000	2,042,000
preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding
common stock, par value 0.001 par value...																																																						32,000	32,000	25,000			17,000	17,000
trade accounts receivable																																																								860,000	2,113,000	1,496,000	1,055,000	1,810,000	1,191,000
related party debt, including accrued interest																																																													49,795,000
stockholders’ equity
preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at december 31, 2011; 88,000,000 shares authorized, 6,322,640 shares issued and outstanding at december 31, 2010
preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at september 30, 2011; 88,000,000 shares authorized, 6,322,640 shares issued and outstanding at december 31, 2010
deferred rent																																																											1,352,000	1,344,000	1,331,000
preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at june 30, 2011; 88,000,000 shares authorized, 6,322,640 shares issued and outstanding at december 31, 2010
other long-term liabilities																																																												2,372,000	2,452,000
preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at march 31, 2011; 88,000,000 shares authorized, 6,322,640 shares issued and outstanding at december 31, 2010
liabilities and stockholders’ deficit
royalty interest obligation, excluding current potion																																																													2,996,000
deferred revenue, excluding current portion																																																													18,138,000
stockholders’ deficit:
preferred stock, par value 0.001, 88,000,000 shares authorized, 6,322,640 issued and outstanding at december 31, 2010 and 2009																																																													6,000
less: treasury stock, 1,065 shares at cost																																																													-2,000
total stockholders’ deficit																																																													-48,383,000
total liabilities and stockholders’ deficit																																																													66,562,000

Cashflow Statements:

Quarterly

Annual

Unit: USD	2026-03-31	2025-12-31	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-12-31	2014-09-30	2014-06-30	2014-03-31	2013-12-31	2013-09-30	2013-06-30	2013-03-31	2012-09-30	2012-06-30	2012-03-31	2011-12-31	2011-09-30	2011-06-30	2011-03-31

operating activities:
net income	2,916,000	1,637,000	5,432,000	-4,847,000	4,812,000	16,041,000	-143,466,000	18,886,000	8,979,000	24,870,000	10,858,000	25,763,000	-19,536,000	-10,102,000	-693,000	19,876,000	6,828,000	-5,130,000	17,660,000	19,081,000	10,369,000	14,515,000	130,119,000	-7,270,000	8,159,000													-3,972,000	-22,165,000	-7,958,000	-3,854,000	-2,498,000	3,086,000	8,000	1,260,000
adjustments to reconcile net income to net cash from operating activities:
deferred taxes	1,730,000	-3,744,000	8,072,000	752,000	1,397,000	3,508,000	1,115,000	12,535,000	3,463,000	6,601,000	4,914,000	11,442,000	-7,342,000	-10,840,000	702,000	2,164,000	29,000	-2,081,000	5,340,000	5,867,000	1,746,000
depreciation of fixed assets and amortization of intangible assets	21,331,000	21,342,000	21,191,000	27,322,000	21,168,000	21,243,000	20,253,000	18,863,000	18,426,000	18,485,000	18,433,000	19,054,000	19,602,000	30,406,000	20,198,000	20,864,000	20,033,000	13,070,000	5,730,000	4,897,000	4,851,000	5,061,000	5,037,000	4,989,000	4,821,000	5,090,000	5,605,000
amortization of debt issuance costs and debt discount	577,000
stock-based compensation	13,539,000	13,499,000	13,978,000	15,472,000	14,553,000	12,266,000	13,230,000	12,524,000	13,151,000	12,420,000	12,530,000	10,955,000	11,990,000	12,677,000	12,682,000	11,544,000	11,189,000	10,890,000	10,785,000	10,461,000	10,110,000	10,896,000	10,954,000	9,223,000	8,847,000	9,189,000	9,244,000	7,783,000	7,434,000	8,186,000	8,107,000	7,047,000	8,385,000	8,194,000	8,663,000	7,344,000	7,400,000	7,732,000	7,361,000	7,665,000	8,490,000	9,728,000	8,827,000	7,296,000	7,517,000	7,623,000	7,687,000	5,537,000	3,975,000	3,286,000	3,777,000	2,225,000	2,225,000	1,469,000	1,039,000	712,000
changes in contingent consideration	-2,277,000	232,000	625,000	-357,000	-2,675,000	1,084,000	-3,244,000	1,509,000	-3,806,000	423,000	2,793,000	-18,258,000	11,618,000	-6,082,000	-1,043,000	-21,280,000	-1,071,000	1,158,000	-1,159,000	139,000	-1,127,000	6,764,000	752,000	1,562,000	-3,874,000	9,345,000
net accretion of discount on available-for-sale investments	-570,000
other net gains
changes in operating assets and liabilities:
accounts receivable	-1,567,000	-8,799,000	-897,000	-9,605,000	8,559,000	-12,651,000	4,127,000	-3,141,000	3,917,000	-8,599,000	2,123,000	-5,875,000	5,192,000	-4,926,000	-2,366,000	998,000	4,215,000	-13,504,000	18,382,000	-15,774,000	462,000	-6,902,000	-2,131,000	-5,025,000	8,542,000	-4,957,000	-1,426,000	-375,000	-1,766,000	-3,734,000	1,375,000	-4,438,000	798,000	-4,637,000	446,000	235,000	2,235,000	-3,172,000	1,886,000	-2,750,000	-46,000	64,000	-1,638,000	230,000	-2,145,000	-1,849,000	28,000	-4,576,000	-1,379,000	-4,819,000
inventories	2,491,000	4,817,000	-9,513,000	-14,399,000	-8,472,000	-13,417,000	-8,427,000	-6,657,000	7,572,000	-7,833,000	-4,390,000	847,000	3,086,000	735,000	3,789,000	3,074,000	-5,112,000	-1,907,000	-1,945,000	-658,000	43,000	3,893,000	-1,852,000	-7,024,000	-1,370,000	1,941,000	-7,448,000	-4,059,000	1,540,000	-3,684,000	-2,831,000	-2,010,000	1,368,000	-2,299,000	-5,510,000	-3,291,000	967,000	6,198,000	23,440,000	2,828,000	-2,099,000	-5,513,000	-7,363,000	-12,505,000	-7,001,000	-5,601,000	-4,468,000	-3,830,000	193,000	49,000			1,317,000						-106,000	-173,000
prepaid expenses and other assets	-4,537,000	12,699,000	4,724,000	-11,524,000	-7,111,000	-1,022,000	-5,029,000	-2,206,000	897,000	-2,653,000	-2,617,000	-2,443,000	-1,926,000	-2,131,000	2,665,000	1,027,000	-4,260,000	235,000	1,851,000	-1,198,000	254,000	-357,000	1,319,000	1,973,000	-3,674,000	-1,434,000	-1,288,000	481,000	-1,644,000	-1,816,000	-1,514,000	1,312,000	-1,210,000	-258,000	1,885,000	-1,202,000	3,051,000	825,000	-4,294,000	3,009,000	-2,917,000	-1,360,000				-751,000	-364,000	-569,000	237,000	-334,000					64,000	366,000
accounts payable	-936,000	-2,929,000	-12,013,000	6,880,000	2,464,000	-325,000	637,000	9,748,000	-6,976,000	-1,072,000	-7,695,000	7,055,000	2,628,000	1,591,000	-577,000	-847,000	6,105,000	-9,437,000	-2,981,000	3,507,000	-1,351,000	-2,195,000	2,400,000	-6,385,000	2,868,000	-2,651,000	2,150,000	121,000	-1,442,000	827,000	1,426,000	-2,932,000	106,000																										-298,000	258,000
accrued expenses	-10,305,000
other liabilities	3,288,000		-5,826,000	9,823,000	1,082,000	3,909,000	-405,000	-19,000	-771,000	394,000	-238,000	-143,000	421,000	-1,179,000	144,000	409,000	70,000	1,767,000	-1,032,000	737,000	-1,701,000	-797,000	1,382,000	-1,879,000	-1,173,000	-5,904,000	-577,000	-194,000	-51,000	85,000	487,000	434,000	-109,000	-556,000	-1,519,000	-419,000	-1,061,000	-1,097,000	-1,574,000	3,177,000	-419,000	4,796,000	952,000	9,000	29,000	210,000	879,000	985,000	278,000	312,000	203,000	82,000	450,000				-2,170,000	1,405,000	-433,000	1,225,000
net cash from operating activities	25,680,000	43,689,000	60,834,000	12,012,000	35,459,000	33,132,000	53,920,000	53,236,000	49,101,000	47,584,000	44,438,000	43,499,000	19,128,000	42,037,000	42,654,000	29,806,000	30,777,000	23,215,000	60,287,000	30,134,000	12,081,000	46,667,000	39,781,000	-15,624,000	6,208,000	25,904,000	18,354,000	22,763,000	3,499,000	21,220,000	16,629,000	13,710,000	-2,689,000	16,931,000	-2,808,000	3,656,000	6,000	17,349,000	11,684,000	7,541,000	-3,121,000	17,035,000	2,817,000	8,651,000	493,000	13,011,000	8,976,000	8,218,000	-4,736,000	-6,280,000									-10,923,000	-3,987,000
capital expenditures	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0									0	0
free cash flows	25,680,000	43,689,000	60,834,000	12,012,000	35,459,000	33,132,000	53,920,000	53,236,000	49,101,000	47,584,000	44,438,000	43,499,000	19,128,000	42,037,000	42,654,000	29,806,000	30,777,000	23,215,000	60,287,000	30,134,000	12,081,000	46,667,000	39,781,000	-15,624,000	6,208,000	25,904,000	18,354,000	22,763,000	3,499,000	21,220,000	16,629,000	13,710,000	-2,689,000	16,931,000	-2,808,000	3,656,000	6,000	17,349,000	11,684,000	7,541,000	-3,121,000	17,035,000	2,817,000	8,651,000	493,000	13,011,000	8,976,000	8,218,000	-4,736,000	-6,280,000									-10,923,000	-3,987,000
investing activities:
acquisition of gq bio therapeutics gmbh	-335,000	0	0	0	-16,702,000
purchases of fixed assets	-2,724,000	-218,000	-3,870,000	-2,697,000	-8,548,000	-2,118,000	-4,092,000	-1,590,000	-2,836,000	-1,798,000	-3,394,000	-3,404,000	-6,565,000	-5,492,000	-5,181,000	-11,735,000	-7,668,000	-9,166,000	-13,076,000	-10,551,000	-13,073,000	-14,408,000	-7,763,000	-8,906,000	-6,724,000	-4,497,000	-1,592,000	-2,052,000	-2,018,000	-2,243,000	-4,453,000	-2,634,000	-5,184,000	-5,076,000	-5,419,000	-5,155,000	-3,616,000	-4,882,000	-3,906,000	-8,868,000	-7,053,000	-9,124,000	-9,604,000	-13,305,000	-9,237,000	-7,112,000	-4,946,000	-6,023,000	-3,808,000
purchases of available-for-sale investments		-27,591,000	-38,765,000	-5,056,000	-69,629,000	-45,195,000	-101,236,000	-49,726,000	-56,055,000	-25,926,000	-42,173,000	-20,012,000	-49,497,000	-68,259,000	-131,785,000	-32,040,000	-155,601,000	-97,996,000
sales of available-for-sale investments	22,500,000	47,142,000	86,249,000	71,166,000	69,250,000	46,945,000	53,165,000	36,101,000	43,361,000	36,098,000	41,225,000	33,500,000	126,245,000	84,940,000	89,700,000			598,122,000
net cash from investing activities	19,441,000	19,333,000	43,614,000	62,163,000	-25,629,000	-368,000	-52,163,000	-15,215,000	-15,530,000	8,374,000	-4,342,000	7,326,000	66,183,000	11,189,000	-47,516,000	19,161,000	-208,019,000	66,918,000	-35,077,000	3,033,000	-55,664,000	-82,317,000	-202,847,000	36,123,000	-28,566,000	-30,795,000	5,625,000	-181,799,000	78,481,000	-123,163,000	94,459,000	59,573,000	-10,293,000	8,699,000	-27,478,000	-61,150,000	-143,836,000	-6,917,000	-13,320,000	-19,642,000	-21,875,000	7,255,000	-6,840,000	-19,483,000	-1,163,000	4,017,000	-101,801,000	-30,574,000	9,019,000	14,599,000
financing activities:
proceeds from exercises of stock options	2,000	490,000								0	26,000	1,580,000	333,000	905,000	1,601,000	10,857,000	11,024,000	4,795,000	3,052,000	5,672,000	10,325,000	9,238,000	29,627,000	2,898,000	3,455,000	3,478,000	1,423,000	2,467,000	1,101,000
payment of employee withholding taxes on restricted stock unit vests	-4,355,000	-143,000	-8,000	-5,285,000	-181,000	-77,000	-32,000	-378,000	-4,000
purchase of treasury stock, inclusive of broker fees	-50,045,000	-48,248,000	-50,041,000
repayment of term loan a facility		0	-98,749,000	-3,750,000	-2,813,000	-2,812,000	-2,813,000	-2,812,000	-2,813,000		-27,812,000
repayment of revolving credit facility	-5,000,000	-5,000,000
net cash from financing activities	-59,398,000	-51,652,000	-257,476,000	-57,505,000	-2,994,000	-1,955,000	-2,845,000	24,980,000	-2,817,000	-1,779,000	-27,787,000	440,000	-153,905,000		-7,775,000	-153,657,000	-181,585,000	361,409,000	3,052,000	5,908,000	10,325,000	10,363,000	209,758,000	3,464,000	-1,281,000	-2,020,000	1,423,000	3,737,000	530,000	3,528,000	2,982,000	2,025,000	419,000	2,280,000	2,688,000	2,338,000	216,856,000	1,070,000	769,000	2,381,000	3,041,000	2,172,000	1,823,000	2,657,000	4,047,000	2,736,000	2,381,000	111,794,000	1,964,000	813,000	979,000	1,187,000	86,186,000	250,000			49,130,000	11,000	0	38,017,000
effect of exchange rate changes on cash and cash equivalents	38,000	-414,000	133,000
net increase in cash and cash equivalents	-14,239,000	10,956,000	-152,895,000	16,874,000	6,836,000	30,809,000	-1,088,000	63,001,000	30,754,000					-5,285,000	-12,637,000			451,542,000	28,262,000			-25,287,000	46,692,000	23,963,000	-23,639,000	-6,911,000	25,402,000	-155,299,000	82,510,000	-98,415,000	114,070,000	75,308,000	-12,563,000			-55,156,000	73,026,000				-21,955,000	26,462,000	-2,200,000	-8,175,000	3,377,000	19,764,000	-90,444,000	89,438,000	6,247,000				16,146,000						-31,881,000	33,198,000
cash and cash equivalents, beginning of period	158,545,000		0	0	276,774,000		0	0	153,298,000		0	0	104,139,000		0	0	585,578,000		0	0	99,957,000		0	0	78,228,000		0	0	132,526,000		0	0	54,126,000		0	0	35,944,000		0	0	56,984,000		0	0	37,520,000		0	0	12,515,000		0	0	10,126,000	0	0	46,168,000		0	0	26,133,000
cash and cash equivalents, end of period	144,306,000		-152,895,000	16,874,000	283,610,000		-1,088,000	63,001,000	184,052,000		12,309,000	51,265,000	35,545,000		-12,637,000	-104,690,000	226,751,000		28,262,000	39,075,000	66,699,000		46,692,000	23,963,000	54,589,000		25,402,000	-155,299,000	215,036,000		114,070,000	75,308,000	41,563,000		-27,598,000	-55,156,000	108,970,000		-867,000	-9,720,000	35,029,000		-2,200,000	-8,175,000	40,897,000		-90,444,000	89,438,000	18,762,000		-5,243,000	-17,646,000	26,272,000	-12,736,000	-3,768,000	25,213,000		-11,048,000	-31,881,000	59,331,000
supplemental cash flow information:
cash paid for interest	1,595,000				2,715,000				3,969,000		4,129,000	3,168,000	17,634,000		8,934,000	4,719,000	9,967,000		1,510,000	1,900,000	1,686,000						0	4,097,000	5,000	4,097,000	6,000	0	4,102,000		4,512,000	4,000	2,380,000																							1,175,000
net cash paid for income taxes	50,000				286,000				-245,000
non-cash investing and financing activities:
fixed assets included in accounts payable and accrued liabilities	1,362,000				767,000				607,000		-918,000	136,000	2,252,000		3,032,000	-3,790,000	6,244,000		-3,377,000	1,063,000	7,033,000
excise tax on share repurchases included in accrued liabilities	403,000
goodwill impairment						0
indefinite-lived intangible asset impairment		0
investment impairment		0
loss on lease terminations
loss on early extinguishment of debt		0				0	0			0	0	0	16,926,000									0												0	0	11,000	3,721,000													0	0	0	3,398,000
other net losses				0	-5,887,000	289,000	-162,000	36,000	73,000
accrued expenses and other liabilities
purchases of debt and equity investments
proceeds from shares issued under employee stock purchase plan		1,232,000	0			934,000	0				-1,000				-1,000				0			1,125,000	0			1,132,000	0			832,000	0			806,000	0			500,000	0			898,000	0
proceeds from revolving credit facility		0
proceeds from 2029 convertible senior notes						0	0
proceeds from term loan a facility											0	0	149,550,000
repayment of 2024 convertible senior notes						0	0							0	0	0	-192,609,000
repayment of 2025 convertible senior notes		0				0	0
repayment of term loan b facility											0	0	-296,875,000
purchase of capped call transactions						0	0
debt extinguishment costs										0	0	0	-5,750,000
payment of debt issuance and financing costs		17,000				0	0			0	0	0	-1,163,000									0												0	0	0	-11,000,000													0
cash and cash equivalents, beginning of year
cash and cash equivalents, end of year
see accompanying notes to consolidated financial statements.
amortization of debt issuance costs			626,000	849,000	845,000	846,000	840,000	763,000	681,000	685,000	683,000	691,000	937,000	1,443,000	904,000	874,000	1,179,000	778,000	666,000	659,000	651,000		629,000	444,000	439,000
amortization of debt discount			56,000	23,000	22,000	22,000	23,000	23,000	24,000	24,000	25,000	28,000	675,000	700,000	695,000	706,000	706,000	5,907,000	5,844,000	5,744,000	5,657,000	5,570,000	5,430,000	3,660,000	3,594,000	3,530,000	3,467,000	3,404,000	3,345,000	3,287,000	3,229,000	3,170,000	3,113,000	3,058,000	3,003,000	2,951,000	1,411,000	1,022,000	1,022,000	1,022,000	1,022,000	1,022,000	1,022,000	1,023,000	1,035,000	1,035,000	1,035,000	1,034,000	1,035,000	1,035,000	1,034,000	1,035,000	855,000
accrued expenses and income taxes payable			7,530,000	-19,377,000	4,702,000	-826,000	11,185,000	-2,110,000	3,471,000	4,117,000	4,615,000	-5,651,000	-25,120,000	3,703,000	-4,522,000	-9,877,000	-9,161,000	22,485,000	1,106,000	-113,000	-18,027,000	10,455,000	5,014,000	3,232,000	-24,700,000	16,209,000	2,160,000	7,010,000	-5,166,000	5,274,000	2,232,000	5,320,000	-7,623,000
purchases of debt investments			0
see accompanying condensed notes to consolidated financial statements.
gain on early extinguishment of debt
impairment of investment														0
impairment of indefinite-lived intangible asset
payment of contingent consideration																	-32,000,000													-1,000	-2,127,000	-2,422,000	-2,293,000	-2,241,000	-2,013,000	-2,114,000	-2,092,000	-2,067,000	-9,919,000	-1,967,000	-1,904,000	-1,992,000	-1,765,000	-1,742,000	-1,620,000	-1,713,000	-9,528,000	-1,193,000	-999,000	-790,000
purchase of treasury stock						0	0
repayment of 2022 convertible senior notes														0	0							0
other losses										-278,000
acquisition of flexion therapeutics, inc.
sale of equity investment																		0	0
purchases of equity and debt investments										0	0	-2,758,000	-4,000,000	0	-250,000	0	-12,750,000	0	-2,967,000
proceeds from common stock issued under employee stock purchase plan
proceeds from term loan a facility maturing march 2028
proceeds from term loan b facility maturing december 2026
repayment of term loan b facility maturing december 2026														-59,375,000	-9,375,000
repayment of term loan a facility maturing march 2028
net decrease in cash and cash equivalents											12,309,000	51,265,000	-68,594,000				-358,827,000				-33,258,000																		-867,000
cash paid for income taxes, net of refunds											1,277,000	594,000	201,000		112,000	4,095,000	9,000		812,000	1,446,000	1,000						212,000			-18,000	0			-4,000	0			-6,000	12,000	99,000	142,000
issuance of common stock from conversion of 2022 convertible senior notes															0
loss on disposal of fixed assets														0	0	184,000	9,000													55,000	0	0	10,000	-6,000	109,000	1,893,000	137,000									1,000	0	149,000	8,000	1,000	0						270,000
loss on investment												34,000	-23,000		76,000	90,000	18,000								3,971,000
loss on investment and other non-operating income																			40,000	2,446,000	155,000
proceeds from debt component of the 2025 convertible senior notes																						0
proceeds from equity component of the 2025 convertible senior notes																						0
retirement of equity component of the 2022 convertible senior notes																						0
net cash (used) provided by financing activities
payment of contingent consideration to myoscience, inc. securityholders																			0			0	0	-9,145,000	-264,000
loss on disposal and impairment of fixed assets																				1,000	-11,000	0	0	0	22,000	12,000
loss on investment (net of stock dividend) and other non-operating income
changes in operating assets and liabilities
deferred revenue																																					-205,000	-357,000	-356,000	-357,000	-356,000	-357,000	-356,000	-357,000	-356,000	-357,000	-356,000	7,678,000	-252,000	257,000									-533,000	1,000,000
acquisition of myoscience, inc.																										992,000	0
proceeds from term loan b credit facility
repayment of 2019 convertible senior notes																										0	0	0	-338,000					0
conversion premium on 2019 convertible senior notes																										0	0
purchases of available for sale investments																				-131,479,000	-186,653,000
sales of available for sale investments																				149,006,000	145,282,000
debt investments																					-1,220,000
amortization of unfavorable lease obligation and debt issuance costs																										434,000	429,000	424,000	420,000	404,000	400,000	395,000	391,000	364,000	360,000	356,000	168,000	120,000	119,000	120,000	120,000	120,000	120,000	119,000	122,000	122,000	122,000	121,000	122,000	122,000	121,000	122,000	94,000
purchases of investments																						-219,852,000	-254,401,000	347,000	-72,610,000	-98,393,000	-78,131,000	-119,272,000	-22,688,000	-180,505,000	-1,000	-52,169,000	-130,580,000	-66,735,000	-161,226,000	-94,449,000	-180,342,000	-34,425,000	-36,600,000	-53,947,000	-67,843,000
sales of investments																						153,103,000	59,317,000	44,682,000	50,768,000	71,103,000	85,348,000	59,830,000	103,187,000	59,586,000	101,040,000	116,798,000	127,764,000	97,751,000	141,180,000	40,568,000	42,214,000	34,457,000	37,105,000	45,140,000	54,925,000
equity investment																										0	0
reversal of deferred tax valuation allowance
conversion premium on the 2019 convertible senior notes
gain on investment
payment of contingent consideration to myoscience, inc securityholders																								-855,000	-4,736,000
net increase in contingent consideration liabilities																											0
net decrease in accrued fixed assets																								-692,000	-423,000				-37,000
net loss																										-4,888,000	-6,087,000	2,730,000	-2,771,000	8,285,000	-640,000	2,564,000	-10,680,000		-7,597,000	-19,743,000	-19,866,000												-11,477,000	-11,956,000	-14,784,000	-14,031,000	-23,138,000	-15,745,000	-8,296,000	-11,894,000	-15,283,000	-9,508,000	-8,762,000	-9,775,000
adjustments to reconcile net loss to net cash from operating activities:
proceeds from issuance of 2022 convertible senior notes
costs for conversions of convertible senior notes
net increase in accrued fixed assets																											2,345,000			32,000	-2,162,000	2,265,000	-233,000	-865,000	760,000	1,115,000	1,179,000	-604,000	477,000	-2,216,000	1,554,000
depreciation of fixed assets																													3,600,000		3,504,000	2,848,000	2,762,000
conversion premium on convertible senior notes																													-233,000
depreciation of fixed assets and amortization of intangibles																																		3,659,000	3,361,000	3,709,000	3,104,000	3,260,000	3,278,000	3,216,000	3,165,000	3,119,000	2,830,000	2,783,000	2,743,000	2,707,000	2,392,000	2,333,000	2,603,000
loss on unexercised investment purchase option																														0
issuance of common stock from conversion of 2019 convertible senior notes																																		0	0	494,000	120,466,000
retirement of equity component of 2019 convertible senior notes																																		0	-2,000	-515,000	-125,811,000
proceeds from exercise of stock options																															2,982,000	1,073,000	419,000	1,474,000	2,691,000	1,761,000	852,000		769,000	1,390,000	3,041,000				4,047,000										230,000	153,000	124,000	11,000	0	1,000
proceeds from 2022 convertible senior notes																																		0	0	0	345,000,000
costs for conversion of convertible senior notes																																		0	-1,000	0	-284,000
restricted cash																																										0	0	0	1,509,000	320,000	339,000	-2,168,000	1,633,000	342,000	-977,000	-998,000	1,523,000			1,299,000			-2,069,000	1,314,000
accounts payable, accrued expenses and income taxes payable																																		4,817,000	-6,009,000	11,607,000	-1,056,000	6,401,000	2,967,000
royalty interest obligation																																										0	0	0	-276,000	-329,000	-264,000	-196,000	-181,000	-98,000
cash paid for interest, including royalty interest obligation																																						0	1,926,000	0	1,926,000	0	1,927,000	0	2,297,000	320,000	2,290,000	332,000	2,251,000	343,000	2,311,000	262,000	584,000	1,008,000	1,114,000	1,168,000	1,166,000	1,213,000
repayment of debt																																				-479,000	-117,712,000													0
accrued payment of contingent consideration
equity component of the 2022 convertible senior notes																																					70,930,000
adjustments to reconcile net income to net cash fromoperating activities:
proceeds from follow-on public offering																																														45,000	0
proceeds from exercise of stock options and warrants																																										1,275,000	1,823,000			1,507,000	2,381,000	1,387,000	1,964,000	813,000	979,000	1,187,000	877,000
conversion of principal and equity component of convertible senior notes																																										-1,000	0
issuance of stock from conversion of convertible senior notes																																										-1,000	0
conversion of principal and premium paid on convertible senior notes																																							0
accounts payable and accrued expenses																																									-6,227,000	7,907,000	-2,984,000	9,334,000	-4,316,000	4,078,000	4,950,000	6,757,000	-1,531,000	3,823,000	3,161,000	3,098,000	162,000
proceeds from convertible senior notes																																																		0	0	0	120,000,000
equity component of convertible senior notes																																																		0
loss on extinguishment of debt																																											0											0
purchases of short-term investments																																											-32,276,000	-42,984,000	-49,937,000	570,000	-87,418,000	-34,046,000	-18,946,000	-12,185,000
sales of short-term investments																																											36,805,000	38,548,000	59,631,000	12,270,000	11,075,000
purchases of long-term investments																																														2,000	-10,984,000
cash paid for income taxes																																											40,000	-1,000	160,000
purchases of fixed assets accrued but not paid
prepaid expenses and other current assets																																												660,000	372,000
proceeds from sales of fixed assets																																																						0
proceeds from borrowings on long-term debt																																																						0
value of warrants issued with debt																																																						0
sale of short-term investments																																																	32,772,000	31,000,000	23,764,000	12,050,000	18,750,000
supplemental cash flow information
noncash investing and financing activities:
depreciation and amortization																																																		1,700,000	1,330,000	1,286,000	1,431,000	1,417,000	1,405,000	1,380,000	1,284,000	1,029,000	1,011,000	990,000
impairment of long-lived assets
purchase of fixed assets																																																											-1,203,000	-832,000
proceeds from initial public offering																																																									0	0	0	38,016,000
proceeds from offering																																																						0
initial public offering costs paid in 2010																																																									0	0
non cash investing and financing activities:
conversion of notes to common stock																																																									0	0	0	51,222,000
conversion of preferred stock to common stock																																																									0	0	0	6,000
adjustments to reconcile net loss to net cash used in operating activities:
value of equity premium on convertible senior notes																																																				0	24,936,000
amortization of unfavorable lease obligation and deferred financing costs
amortization of end of term fee and warrants																																																						261,000
accounts receivable, net of allowances
net purchases of short-term investments
amortization of deferred financing costs and unfavorable lease obligation
amortization of note discounts and warrants																																																								103,000	104,000	249,000	98,000	1,193,000
change in royalty interest obligation																																																											-816,000	-76,000
trade accounts receivable																																																								1,253,000			755,000	-619,000
proceeds from sale of short-term investments																																																								371,000
financing costs
proceeds from sale of fixed assets
purchase of short-term investments
proceeds from secondary offering
proceeds from convertible notes
proceeds from secured promissory notes and credit facility
payoff of credit facility
accrual for repurchase of intangibles
accrued fixed asset purchase
value of warrants issued with debt and beneficial conversion feature
value of warrants issued to landlord
accrued financing cost
share-based compensation																																																										442,000	551,000	972,000
proceeds from secured promissory notes
proceeds from credit facility
amortization of other assets and unfavorable lease obligation																																																											-72,000	93,000
deferred rent																																																											8,000	13,000
other current assets																																																												-402,000
initial public offering issuance costs paid in 2010																																																												907,000
impairment loss
proceeds from issuance of preferred stock
proceeds from exercise of stock options and issuance of common stock
accrued fixed asset purchases

Pacira BioSciences, Inc(NASDAQ:PCRX)

Pacira BioSciences, Inc
(NASDAQ:PCRX)