7Baggers
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 
      
                                                               
      assets
                                                               
      current assets:
                                                               
      cash and cash equivalents
    147,589,000 300,484,000 283,610,000 276,774,000 245,965,000 247,053,000 184,052,000 153,298,000 99,119,000 86,810,000 35,545,000 104,139,000 109,424,000 122,061,000 226,751,000 585,578,000 134,036,000 105,774,000 66,699,000 99,957,000 125,244,000 78,552,000 54,589,000 78,228,000 85,139,000 59,737,000 215,036,000 132,526,000 230,941,000 116,871,000 41,563,000 54,126,000 26,216,000 53,814,000 108,970,000 35,944,000 24,442,000 25,309,000 35,029,000 56,984,000 30,522,000 32,722,000 40,897,000 37,520,000 17,756,000 108,200,000 18,762,000 12,515,000 3,383,000 8,626,000 26,272,000 8,709,000 21,445,000 25,213,000 46,168,000 16,402,000 27,450,000 59,331,000 26,133,000 
      short-term available-for-sale investments
    98,745,000 145,380,000 210,016,000 207,841,000 207,845,000 157,173,000 141,838,000 125,283,000 136,069,000 133,956,000 138,454,000 184,512,000 219,301,000 194,332,000 225,443,000 70,831,000 559,822,000                                           
      accounts receivable
    115,268,000 114,367,000 104,745,000 113,304,000 100,653,000 104,779,000 101,639,000 105,556,000 96,956,000 99,079,000 93,205,000 98,397,000 93,471,000 91,105,000 92,103,000 96,318,000 49,975,000 68,357,000 52,583,000 53,046,000 46,143,000 44,013,000 38,988,000 47,530,000 42,573,000 41,147,000 39,766,000 38,000,000 34,266,000 35,641,000 31,203,000 31,658,000 27,021,000 27,467,000 27,702,000 29,937,000 26,765,000 28,651,000 25,901,000 25,855,000 25,919,000 24,281,000 24,511,000 22,366,000 20,517,000 20,545,000 15,969,000 14,590,000 9,771,000 7,756,000 5,243,000 2,459,000 3,214,000       
      inventories
    157,680,000 148,163,000 133,754,000 125,282,000 111,865,000 103,438,000 96,782,000 104,353,000 96,520,000 92,130,000 92,977,000 96,063,000 96,799,000 100,588,000 103,662,000 98,550,000 67,209,000 65,264,000 64,606,000 64,650,000 68,542,000 66,690,000 59,666,000 58,296,000 60,238,000 52,697,000 47,028,000 48,569,000 44,884,000 42,053,000 40,043,000 41,411,000 39,112,000 33,602,000 30,311,000 31,278,000 37,476,000 60,916,000 63,744,000 61,645,000 56,132,000 48,769,000 36,264,000 29,263,000 23,662,000 19,194,000 15,364,000 15,557,000 15,606,000 14,221,000 10,760,000 11,906,000 9,299,000 5,078,000 1,245,000 1,667,000 1,884,000 1,778,000 1,605,000 
      prepaid expenses and other current assets
    43,469,000 37,219,000 27,837,000 21,929,000 23,641,000 19,771,000 18,802,000 21,504,000 18,591,000 17,349,000 15,933,000 15,223,000 14,416,000 18,124,000 19,059,000 14,771,000 11,310,000 12,363,000 12,995,000 12,265,000 11,710,000 18,328,000 14,476,000 10,781,000 10,392,000 8,526,000 9,437,000 7,946,000 6,490,000 6,039,000 7,700,000 6,694,000 5,622,000 7,480,000 6,252,000 9,277,000 10,075,000 5,755,000 8,959,000 6,117,000 4,611,000 3,429,000 4,089,000 4,461,000 3,504,000 3,139,000 2,572,000 2,819,000 2,486,000 2,559,000 2,740,000 2,024,000 1,431,000 1,496,000 1,839,000 1,482,000 1,391,000 1,107,000 812,000 
      total current assets
    562,751,000 745,613,000 759,962,000 745,130,000 689,969,000 632,214,000 543,113,000 509,994,000 447,255,000 429,324,000 376,114,000 498,334,000 533,411,000 526,210,000 667,018,000 866,048,000 822,352,000 792,579,000 720,247,000 651,623,000 658,520,000 455,823,000 431,594,000 408,557,000 378,847,000 394,609,000 508,673,000 477,969,000 472,049,000 455,054,000 418,734,000 391,110,000 365,835,000 450,991,000 447,964,000 243,089,000 235,444,000 257,989,000 248,625,000 252,582,000 233,100,000 229,626,000 219,750,000 214,257,000 199,240,000 208,906,000 98,478,000 106,751,000 111,685,000 121,490,000 128,989,000 85,129,000 100,076,000 62,264,000 82,649,000 43,400,000 53,604,000 64,026,000 31,055,000 
      fixed assets
    147,388,000 155,178,000 164,451,000 167,169,000 166,852,000 168,850,000 171,804,000 173,927,000 175,783,000 180,310,000 181,617,000 183,512,000 193,646,000 191,279,000 189,767,000 188,401,000 159,235,000 153,302,000 144,822,000 136,688,000 125,527,000 113,297,000 108,105,000 104,681,000 104,856,000 105,492,000 107,051,000 108,670,000 110,063,000 111,276,000 109,225,000 107,046,000 105,947,000 103,239,000 102,571,000 101,016,000 100,388,000 99,282,000 95,846,000 90,324,000 86,323,000 77,809,000 67,206,000 60,632,000 56,148,000 53,513,000 49,891,000 48,182,000 45,944,000 42,065,000 41,130,000 35,319,000 29,966,000 26,492,000 25,103,000 25,825,000 24,633,000 24,359,000 23,950,000 
      right-of-use assets
    44,266,000 46,528,000 48,728,000 49,222,000 53,830,000 56,264,000 58,626,000 61,020,000 63,394,000 65,837,000 68,084,000 70,877,000 69,662,000 72,082,000 74,271,000 76,410,000 69,790,000 71,252,000 72,888,000 74,492,000 76,047,000 77,799,000 37,613,000 38,124,000 35,756,000 36,494,000 26,686,000                                 
      goodwill
    20,317,000 20,300,000 21,520,000   163,243,000 163,243,000 163,243,000 163,243,000 163,243,000 163,243,000 163,243,000 157,361,000 146,132,000 145,722,000 145,175,000 99,547,000 99,547,000 99,547,000 99,547,000 99,547,000 99,547,000 99,547,000 99,547,000 99,547,000 100,538,000 62,040,000 62,040,000 62,040,000 59,912,000 57,490,000 55,197,000 52,956,000 50,943,000 48,829,000 46,737,000 44,670,000 42,751,000 32,784,000 30,880,000 28,888,000 27,123,000 25,381,000 23,761,000 22,048,000 12,520,000 11,327,000 10,328,000 9,539,000 8,980,000 8,582,000 8,109,000 7,992,000       
      intangible assets
    382,396,000 422,563,000 434,969,000 425,970,000 440,292,000 454,614,000 468,936,000 483,258,000 497,580,000 511,902,000 526,224,000 540,546,000 581,002,000 595,324,000 609,646,000 623,968,000 90,621,000 92,588,000 94,554,000 96,521,000 98,487,000 100,454,000 102,421,000 104,387,000 106,354,000 108,320,000                                  
      deferred tax assets
    120,188,000 128,270,000 129,008,000 130,376,000 134,022,000 135,136,000 141,057,000 144,485,000 151,660,000 156,140,000 167,570,000 160,309,000 155,531,000 167,149,000 169,282,000 153,364,000 93,265,000 98,599,000 104,467,000 106,164,000 104,122,000                                       
      investments and other assets
    20,271,000 18,810,000 28,031,000 35,649,000 36,726,000 36,499,000 36,542,000 36,049,000 35,547,000 35,625,000 32,285,000 27,170,000 26,358,000 35,812,000 35,770,000 21,987,000 21,192,000                                           
      total assets
    1,297,577,000 1,537,262,000 1,586,669,000 1,553,516,000 1,521,691,000 1,646,820,000 1,583,321,000 1,574,386,000 1,534,462,000 1,542,381,000 1,523,418,000 1,681,200,000 1,734,365,000 1,733,988,000 1,891,476,000 2,075,353,000 1,356,002,000 1,325,833,000 1,287,549,000 1,274,513,000 1,220,269,000 866,111,000 821,379,000 831,065,000 807,489,000 787,843,000 719,156,000 689,353,000 659,045,000 642,681,000 622,037,000 628,371,000 606,090,000 605,745,000 599,962,000 391,466,000 381,153,000 400,699,000 391,206,000 389,623,000 368,988,000 354,993,000 335,030,000 326,072,000 305,394,000 292,080,000 163,693,000 169,820,000 172,395,000 178,430,000 185,241,000 132,826,000 142,853,000 94,264,000 113,490,000 77,609,000 87,092,000 97,869,000 66,562,000 
      liabilities and stockholders’ equity
                                                               
      current liabilities:
                                                               
      accounts payable
    17,687,000 30,124,000 23,172,000 19,133,000 19,367,000 18,730,000 8,982,000 15,698,000 16,511,000 24,206,000 17,261,000 15,220,000 12,933,000 13,983,000 14,843,000 10,543,000 7,895,000 12,179,000 9,110,000 10,431,000 13,008,000 9,160,000 15,850,000 12,799,000 16,064,000 13,347,000 13,369,000 14,368,000 13,795,000 14,260,000 14,913,000 14,658,000 12,278,000 10,392,000 9,373,000 7,511,000 7,287,000 4,614,000 10,484,000 8,739,000 8,471,000 13,299,000 5,565,000 6,758,000 7,747,000 3,145,000 2,605,000 3,069,000 1,559,000 1,712,000 1,001,000 4,789,000 440,000 2,302,000 3,440,000 4,313,000 5,052,000 6,097,000 6,038,000 
      accrued expenses
    79,643,000 71,023,000 80,069,000 80,124,000 76,377,000 64,811,000 66,818,000 64,243,000 59,884,000 56,221,000 61,633,000 89,785,000 76,357,000 77,275,000 87,669,000 127,555,000 50,798,000 52,163,000 50,239,000 70,974,000 60,403,000 47,684,000 44,717,000 70,427,000 61,002,000 51,907,000 39,696,000 45,865,000    41,057,000 39,701,000 46,755,000 34,900,000 36,666,000 31,077,000 38,330,000 29,067,000 35,375,000 30,295,000 26,790,000 25,296,000 28,450,000 23,383,000 23,035,000 16,913,000 17,885,000 15,573,000 12,260,000 9,872,000 13,036,000 9,279,000 7,040,000 7,159,000 4,998,000 3,641,000 3,830,000 3,260,000 
      lease liabilities
    9,748,000 9,620,000 9,405,000 8,887,000 9,191,000 9,149,000 9,003,000 8,801,000 8,625,000 8,981,000 8,951,000 9,121,000 8,364,000 8,134,000 8,018,000 7,891,000 5,879,000 5,644,000 5,503,000 7,425,000 7,455,000 7,620,000 3,968,000 4,935,000 5,043,000 6,172,000 5,583,000                                 
      current portion of long-term debt
             10,863,000 10,853,000 33,648,000 33,872,000 33,776,000 33,680,000 24,234,000                                      1,364,000 7,039,000 4,871,000 4,869,000 5,568,000 3,182,000 
      total current liabilities
    107,078,000 313,164,000 314,732,000 309,920,000 306,401,000 92,690,000 93,444,000 97,383,000 93,661,000 108,912,000 98,698,000 147,774,000 131,526,000 133,179,000 305,073,000 521,118,000 225,788,000 228,693,000 232,084,000 253,328,000 86,272,000 70,583,000 80,313,000 107,673,000 95,838,000 83,004,000 58,991,000 60,661,000 54,523,000 53,024,000 48,368,000 56,217,000 52,337,000 57,510,000 45,648,000 44,838,000 146,831,000 150,438,000 146,139,000 151,676,000 145,411,000 145,472,000 136,453,000 140,010,000 135,223,000 129,506,000 121,587,000 121,943,000 116,972,000 15,835,000 12,698,000 19,828,000 15,236,000 19,158,000 31,911,000 17,829,000 17,479,000 19,663,000 16,322,000 
      long-term debt
    376,721,000 97,828,000 101,489,000 104,211,000 107,024,000 109,751,000 112,477,000 115,202,000 117,965,000 134,823,000 137,534,000 251,056,000 309,848,000 318,344,000 326,828,000 335,263,000                                    24,930,000 24,670,000 23,632,000 18,537,000 20,603,000 20,358,000 19,570,000 21,869,000 
      contingent consideration
    17,834,000 17,209,000 17,566,000 20,241,000 19,157,000 22,401,000 20,892,000 24,698,000 24,275,000 21,482,000 39,740,000 28,122,000 34,204,000 35,247,000 56,527,000  5,070,000 5,026,000 14,864,000 14,736,000 5,406,000 4,504,000 14,041,000 18,179,000 13,591,000 11,500,000                                  
      deferred tax liabilities
    4,587,000 4,583,000 6,996,000                                                         
      other liabilities
    25,304,000 25,153,000 23,866,000 16,817,000 12,784,000 13,005,000 12,690,000 13,573,000 11,945,000 11,783,000 11,579,000 9,669,000 19,112,000 19,473,000 10,722,000 9,847,000 7,553,000 7,697,000 5,288,000 3,832,000 4,219,000 2,984,000 1,535,000 1,502,000 2,320,000 8,993,000 8,993,000 16,874,000 16,363,000 15,886,000 15,463,000 16,498,000 16,232,000 17,859,000 10,332,000 11,427,000 12,557,000 14,163,000 11,020,000 11,473,000 6,125,000 5,447,000 5,404,000 5,409,000 5,235,000 4,384,000 3,435,000 3,190,000 2,911,000 2,743,000 2,694,000 2,399,000 2,538,000 2,675,000 2,778,000 3,571,000 2,292,000   
      total liabilities
    570,363,000 779,495,000 788,128,000 775,168,000 772,108,000 767,542,000 691,159,000 704,256,000 702,911,000 734,406,000 755,377,000 906,190,000 964,242,000 977,352,000 1,181,900,000 1,344,945,000 637,400,000 638,665,000 636,731,000 654,825,000 635,579,000 477,963,000 447,342,000 476,121,000 461,327,000 446,193,000 391,637,000 368,127,000 357,779,000 352,168,000 343,516,000 348,888,000 341,290,000 344,697,000 329,329,000 172,490,000 167,005,000 172,348,000 165,036,000 171,231,000 159,975,000 159,714,000 151,009,000 154,927,000 150,322,000 144,111,000 127,982,000 128,571,000 123,277,000 119,288,000 115,449,000 52,381,000 48,348,000 57,022,000 65,221,000 63,734,000 64,157,000 66,723,000 114,945,000 
      commitments and contingencies
                                                               
      stockholders’ equity:
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2025 and december 31, 2024
                                                               
      common stock
    48,000 48,000 47,000 47,000 47,000 47,000 47,000 46,000 46,000 46,000 46,000 46,000 46,000 46,000 45,000 45,000 45,000 44,000 44,000 44,000 43,000 43,000 42,000 42,000 42,000 42,000 41,000 41,000 41,000 41,000 41,000 41,000 41,000 40,000 40,000 37,000 37,000 37,000 37,000 37,000 37,000 37,000 36,000 36,000 36,000 36,000 34,000 34,000 34,000 33,000 33,000 32,000 32,000 25,000 25,000 17,000 17,000 17,000 1,000 
      treasury stock
    -125,543,000 -75,515,000 -25,121,000 -25,121,000 -25,121,000 -25,121,000                                           -2,000        -2,000 -2,000  
      additional paid-in capital
    1,049,545,000 1,035,563,000 1,023,808,000 1,009,435,000 996,376,000 983,178,000 989,780,000 976,633,000 963,181,000 950,626,000 936,419,000 924,095,000 909,396,000 895,151,000 867,890,000 942,091,000 925,169,000 911,368,000 894,108,000 873,201,000 852,190,000 785,124,000 766,280,000 753,978,000 740,183,000 729,531,000 718,449,000 709,691,000 697,977,000 686,888,000 677,836,000 669,032,000 658,557,000 647,206,000 637,066,000 565,207,000 556,405,000 548,277,000 538,227,000 526,696,000 514,796,000 504,146,000 492,898,000 481,334,000 470,975,000 460,907,000 343,578,000 337,639,000 333,542,000 328,787,000 325,375,000 296,525,000 294,806,000 229,335,000 228,470,000 178,821,000 178,368,000 177,817,000 88,523,000 
      accumulated deficit
    -200,959,000 -206,391,000 -201,544,000 -206,356,000 -222,397,000 -78,931,000 -97,817,000 -106,796,000 -131,666,000 -142,524,000 -168,287,000 -148,751,000 -138,649,000 -137,956,000 -157,832,000 -211,895,000 -206,765,000 -224,425,000 -243,506,000 -253,875,000 -268,390,000 -398,509,000 -391,239,000 -399,398,000 -394,510,000 -388,423,000 -391,153,000 -388,226,000 -396,511,000 -395,871,000 -398,455,000 -389,136,000 -393,731,000 -386,134,000 -366,391,000 -346,238,000 -342,266,000 -320,101,000 -312,143,000 -308,289,000 -305,791,000 -308,877,000 -308,885,000 -310,145,000 -315,947,000 -312,943,000 -307,906,000 -296,429,000 -284,473,000        -155,448,000 -146,686,000 -136,911,000 
      accumulated other comprehensive income
    4,123,000 4,062,000 1,351,000 343,000 678,000 105,000 152,000 247,000    -380,000 -670,000 -605,000 -527,000 167,000 153,000 181,000 172,000 318,000 847,000 1,490,000 -1,046,000 322,000 447,000 500,000 182,000           138,000 49,000     -80,000 8,000 -31,000 5,000 5,000 17,000 13,000 44,000 64,000 98,000 17,000 15,000     
      total stockholders’ equity
    727,214,000 757,767,000 798,541,000 778,348,000 749,583,000 879,278,000 892,162,000 870,130,000 831,551,000 807,975,000 768,041,000 775,010,000 770,123,000 756,636,000 709,576,000 730,408,000 718,602,000 687,168,000 650,818,000 619,688,000 584,690,000 388,148,000 374,037,000 354,944,000 346,162,000 341,650,000 327,519,000 321,226,000 301,266,000 290,513,000 278,521,000 279,483,000 264,800,000 261,048,000 270,633,000 218,976,000 214,148,000 228,351,000 226,170,000 218,392,000 209,013,000 195,279,000 184,021,000 171,145,000 155,072,000 147,969,000 35,711,000  49,118,000 59,142,000 69,792,000 80,445,000 94,505,000 37,242,000 48,269,000 13,875,000 22,935,000 31,146,000  
      total liabilities and stockholders’ equity
    1,297,577,000 1,537,262,000 1,586,669,000 1,553,516,000 1,521,691,000 1,646,820,000 1,583,321,000 1,574,386,000 1,534,462,000 1,542,381,000 1,523,418,000 1,681,200,000 1,734,365,000 1,733,988,000 1,891,476,000 2,075,353,000 1,356,002,000 1,325,833,000 1,287,549,000 1,274,513,000 1,220,269,000 866,111,000 821,379,000 831,065,000 807,489,000 787,843,000 719,156,000 689,353,000 659,045,000 642,681,000 622,037,000 628,371,000 606,090,000 605,745,000 599,962,000 391,466,000 381,153,000 400,699,000 391,206,000 389,623,000 368,988,000 354,993,000 335,030,000 326,072,000 305,394,000 292,080,000 163,693,000  172,395,000 178,430,000 185,241,000 132,826,000 142,853,000 94,264,000 113,490,000 77,609,000 87,092,000 97,869,000  
      current portion of convertible senior notes
     202,397,000 202,086,000 201,776,000 201,466,000  8,641,000 8,641,000 8,641,000 8,641,000                                                  
      convertible senior notes
     280,267,000 279,801,000 279,334,000 278,867,000 479,549,000 399,210,000 398,594,000 397,976,000 397,360,000 405,384,000    160,000,000 350,466,000 155,751,000 153,681,000 151,647,000 149,648,000 456,464,000 314,182,000 310,078,000     338,000 334,000 330,000 327,000 324,000 320,000 319,000 759,000  107,563,000 106,388,000 105,215,000 105,928,000 104,907,000 103,885,000 104,135,000 103,100,000 102,065,000 101,031,000 99,996,000 98,961,000 97,927,000           
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2025 and december 31, 2024
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at march 31, 2025 and december 31, 2024
                                                               
      noncurrent available-for-sale investments
           2,410,000   8,281,000 37,209,000 17,394,000                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at december 31, 2024 and 2023
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2024 and december 31, 2023
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2024 and december 31, 2023
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at march 31, 2024 and december 31, 2023
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at december 31, 2023 and 2022
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2023 and december 31, 2022
                                                               
      accumulated other comprehensive loss
            -10,000 -173,000 -137,000                 -280,000 -241,000 -545,000 -901,000 -454,000 -67,000 -64,000 -82,000 -30,000 -28,000   -52,000 -29,000 -27,000 -28,000                 
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2023 and december 31, 2022
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at march 31, 2023 and december 31, 2022
                                                               
      income taxes payable
                 11,000 863,000 429,000 395,000  721,000 114,000  1,615,000 1,737,000 1,333,000 138,000 78,000 343,000 90,000 35,000  111,000 76,000 38,000 44,000 96,000 66,000 82,000 58,000 98,000 208,000 312,000 72,000 31,000                 
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at december 31, 2022 and 2021
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2022 and december 31, 2021
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2022 and december 31, 2021
                                                               
      deferred revenue
                  10,125,000 10,125,000                   7,357,000 7,487,000 7,617,000 7,747,000 7,877,000 8,082,000 8,439,000 8,795,000 9,152,000 9,508,000 9,864,000 10,221,000 2,960,000 3,212,000 2,991,000 3,234,000 3,477,000 4,343,000 4,634,000 8,073,000 8,416,000 17,847,000 18,414,000 18,855,000  
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at march 31, 2022 and december 31, 2021
                                                               
      long-term available-for-sale investments
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at december 31, 2021 and 2020
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2021 and december 31, 2020
                                                               
      short-term investments
                     540,821,000 523,364,000 421,705,000 406,881,000 248,240,000 263,875,000 213,722,000 180,505,000 232,502,000 197,406,000 250,928,000 155,468,000 254,450,000 298,225,000 257,221,000 267,864,000 328,628,000 274,729,000 136,653,000 136,686,000 137,358,000 114,992,000 101,981,000 115,916,000 120,425,000 113,989,000 119,138,000 131,972,000 55,660,000 45,811,000 59,637,000 78,464,000 87,330,000 83,974,000 58,240,000 62,840,000 29,617,000 29,985,000 20,666,000 19,755,000   
      long-term investments
                      34,971,000 95,459,000 44,062,000 8,261,000 35,120,000 64,798,000 70,577,000 25,362,000  25,871,000  1,601,000 21,683,000 60,047,000 80,807,000      13,470,000 13,462,000 17,921,000 17,941,000 19,938,000 24,431,000 24,527,000 13,474,000              
      equity investments and other assets
                     17,966,000 16,053,000 14,019,000                                        
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2021 and december 31, 2020
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at march 31, 2021 and december 31, 2020
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at december 31, 2020 and 2019
                                                               
      equity investment and other assets
                        13,957,000 10,930,000 6,979,000 10,971,000 11,552,000 17,028,000                                  
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2020 and december 31, 2019
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2020 and december 31, 2019
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at march 31, 2020 and december 31, 2019
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at december 31, 2019 and 2018
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2019 and december 31, 2018
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2019 and december 31, 2018
                                                               
      equity investment
                              14,146,000 14,146,000 14,146,000 14,146,000 14,146,000 14,146,000                            
      other assets
                              560,000 657,000 747,000 692,000 759,000 825,000 545,000 572,000 598,000 624,000 651,000 677,000 481,000 2,294,000 2,595,000 2,252,000 2,432,000 2,588,000 2,948,000 3,103,000 3,353,000 3,402,000 3,557,000 3,712,000 3,845,000 548,000 586,000 762,000 479,000 1,180,000 1,075,000 1,138,000 2,645,000 
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at march 31, 2019 and december 31, 2018
                                                               
      current portion of deferred revenue
                                   102,000   520,000 595,000 822,000 1,048,000 1,275,000 1,426,000 1,426,000 1,426,000 1,426,000 1,426,000 1,426,000 1,426,000 1,008,000 1,008,000 972,000 972,000 972,000 1,166,000 4,353,000 7,231,000 13,054,000 2,354,000 2,458,000 2,550,000 2,267,000 
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at december 31, 2018 and 2017
                                                               
      accrued expenses and current portion of deferred revenue
                                40,359,000 38,434,000 33,017,000                             
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2018 and december 31, 2017
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2018 and december 31, 2017
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at march 31, 2018 and december 31, 2017
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at december 31, 2017 and 2016
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2017 and december 31, 2016
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2017 and december 31, 2016
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at march 31, 2017 and december 31, 2016
                                                               
      intangibles
                                           81,000 161,000 242,000 323,000 403,000 483,000 564,000 644,000 1,157,000 1,670,000 2,183,000 2,695,000 3,721,000 4,233,000 4,746,000 5,259,000 7,204,000 7,780,000 8,346,000 8,912,000 
      preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at december 31, 2016 and 2015
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2016 and december 31, 2015
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2016 and december 31, 2015
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at march 31, 2016 and december 31, 2015
                                                               
      restricted cash
                                               1,509,000 1,829,000 2,168,000  1,633,000 1,975,000 998,000  1,791,000 1,847,000  1,299,000 1,687,000 2,069,000  1,314,000 
      current portion of royalty interest obligation
                                               276,000 602,000 869,000 1,065,000 1,020,000 941,000 891,000 853,000 837,000 1,164,000 1,221,000 1,219,000 1,293,000 1,459,000 1,618,000 1,575,000 
      preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at december 31, 2015 and 2014
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at september 30, 2015 and december 31, 2014
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized; none issued and outstanding at june 30, 2015 and december 31, 2014
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at march 31, 2015 and december 31, 2014
                                                               
      royalty interest obligation
                                                   226,000 403,000 584,000 723,000 881,000 1,270,000 1,442,000 1,537,000 1,842,000 2,220,000 2,877,000 -930,000 
      preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at december 31, 2014 and 2013
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at september 30, 2014 and december 31, 2013
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at june 30, 2014 and december 31, 2013
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at march 31, 2014 and december 31, 2013
                                                               
      liabilities and stockholders' equity
                                                               
      stockholders' equity:
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at december 31, 2013 and 2012
                                                               
      total stockholders' equity
                                                   41,249,000            
      total liabilities and stockholders' equity
                                                   169,820,000            
      preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at september 30, 2013 and december 31, 2012
                                                               
      long-term debt, net of debt discount
                                                     96,892,000          
      preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at june 30, 2013 and december 31, 2012
                                                               
      long-term debt, net of discount
                                                      95,857,000         
      preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at march 31, 2013 and december 31, 2012
                                                               
      contingent purchase liability
                                                         2,042,000 2,042,000 2,042,000 2,042,000 2,042,000 2,042,000 
      preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding
                                                               
      trade accounts receivable
                                                         860,000 2,113,000 1,496,000 1,055,000 1,810,000 1,191,000 
      related party debt, including accrued interest
                                                              49,795,000 
      stockholders’ equity
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at december 31, 2011; 88,000,000 shares authorized, 6,322,640 shares issued and outstanding at december 31, 2010
                                                               
      preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at september 30, 2011; 88,000,000 shares authorized, 6,322,640 shares issued and outstanding at december 31, 2010
                                                               
      deferred rent
                                                            1,352,000 1,344,000 1,331,000 
      preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at june 30, 2011; 88,000,000 shares authorized, 6,322,640 shares issued and outstanding at december 31, 2010
                                                               
      other long-term liabilities
                                                             2,372,000 2,452,000 
      preferred stock, par value 0.001; 5,000,000 shares authorized, none issued and outstanding at march 31, 2011; 88,000,000 shares authorized, 6,322,640 shares issued and outstanding at december 31, 2010
                                                               
      liabilities and stockholders’ deficit
                                                               
      royalty interest obligation, excluding current potion
                                                              2,996,000 
      deferred revenue, excluding current portion
                                                              18,138,000 
      stockholders’ deficit:
                                                               
      preferred stock, par value 0.001, 88,000,000 shares authorized, 6,322,640 issued and outstanding at december 31, 2010 and 2009
                                                              6,000 
      less: treasury stock, 1,065 shares at cost
                                                              -2,000 
      total stockholders’ deficit
                                                              -48,383,000 
      total liabilities and stockholders’ deficit
                                                              66,562,000 
      revenues:
                                                               
      supply revenue
                                                              7,640,000 
      royalties
                                                              3,705,000 
      collaborative licensing and development revenue
                                                              3,217,000 
      total revenues
                                                              14,562,000 
      operating expenses:
                                                               
      cost of revenues
                                                              12,276,000 
      research and development
                                                              18,628,000 
      selling, general and administrative
                                                              6,030,000 
      total operating expenses
                                                              36,934,000 
      income from operations
                                                              -22,372,000 
      other income
                                                              150,000 
      loss on early extinguishment of debt
                                                              -184,000 
      interest:
                                                               
      interest income
                                                              146,000 
      interest expense
                                                              -3,959,000 
      net income
                                                              -27,149,000 
      basic and diluted net income per common share
                                                              -47,290 
      weighted-average common shares outstanding—basic and diluted
                                                              574,072,000 
    The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.