Madrigal Pharmaceuticals, Inc(NASDAQ:MDGL) 
Madrigal Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, focuses on the development and commercialization of therapeutic candidates for the treatment of cardiovascular, metabolic, and liver diseases. Its lead product candidate is MGL-3196, a liver-directed selective thyroid hormon...
Website: http://www.madrigalpharma.com
Founded: 2011
Full Time Employees: 29
Sector: Healthcare
Industry: Biotechnology
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At a glance:
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Quarterly
Annual
| Unit: USD | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 | 2013-09-30 | 2013-06-30 | 2013-03-31 | 2012-09-30 | 2012-06-30 | 2012-03-31 | 2011-09-30 | 2011-06-30 | 2011-03-31 | 2010-09-30 | 2010-06-30 | 2010-03-31 | 2009-09-30 | 2007-09-30 | 2007-06-30 | 2006-12-31 |
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revenues: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
product revenue | 311,337,000 | 321,083,000 | 287,268,000 | 212,802,000 | 137,250,000 | 103,320,000 | 62,175,000 | 14,638,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
operating expenses: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cost of sales | 26,847,000 | 24,448,000 | 18,122,000 | 9,065,000 | 4,513,000 | 3,445,000 | 2,152,000 | 636,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
research and development | 108,692,000 | 116,268,000 | 174,004,000 | 54,081,000 | 44,172,000 | 25,648,000 | 68,742,000 | 71,091,000 | 71,237,000 | 70,640,000 | 70,951,000 | 68,605,000 | 62,154,000 | 70,742,000 | 68,271,000 | 58,499,000 | 47,929,000 | 52,889,000 | 54,873,000 | 51,632,000 | 45,770,000 | 53,429,000 | 53,292,000 | 44,688,000 | 33,400,000 | 24,910,000 | 19,447,000 | 15,594,000 | 12,373,000 | 6,211,000 | 5,109,000 | 5,198,000 | 6,682,000 | 6,816,000 | 4,380,000 | 7,804,921 | 3,407,000 | 14,413,000 | 16,377,000 | 16,182,000 | 16,208,000 | 18,761,000 | 17,583,000 | 17,623,000 | 17,876,000 | 16,380,000 | 11,743,000 | 11,252,000 | 12,066,000 | 10,751,000 | 10,417,000 | 9,436,000 | 11,023,000 | 9,688,000 | 10,195,000 | 9,084,000 | 13,613,000 | |||
selling, general and administrative | 268,521,000 | 239,976,000 | 209,117,000 | 196,858,000 | 167,876,000 | 141,223,000 | 107,585,000 | 105,448,000 | 80,800,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||
total operating expenses | 404,060,000 | 380,692,000 | 401,243,000 | 260,004,000 | 216,561,000 | 170,316,000 | 178,479,000 | 177,175,000 | 152,037,000 | 117,176,000 | 98,534,000 | 86,450,000 | 78,336,000 | 85,299,000 | 80,412,000 | 70,273,000 | 57,587,000 | 64,601,000 | 63,160,000 | 61,742,000 | 52,979,000 | 59,555,000 | 58,786,000 | 50,327,000 | 38,005,000 | 29,954,000 | 24,195,000 | 22,704,000 | 18,119,000 | 11,333,000 | 7,826,000 | 7,069,000 | 8,637,000 | 8,439,000 | 6,075,000 | 14,090,518 | 3,489,000 | 6,447,000 | 17,394,000 | 19,504,000 | 20,332,000 | 19,449,000 | 21,701,000 | 22,907,000 | 21,794,000 | 22,063,000 | 20,258,000 | 14,539,000 | 14,134,000 | 14,712,000 | 13,882,000 | 13,363,000 | 12,109,000 | 13,614,000 | 12,404,000 | 13,281,000 | 12,233,000 | 17,466,000 | ||
income from operations | -92,723,000 | -59,609,000 | -113,975,000 | -47,202,000 | -79,311,000 | -66,996,000 | -116,304,000 | -162,537,000 | -152,037,000 | -117,176,000 | -98,534,000 | -86,450,000 | -78,336,000 | -85,299,000 | -80,412,000 | -70,273,000 | -57,587,000 | -64,601,000 | -63,160,000 | -61,742,000 | -52,979,000 | -59,555,000 | -58,786,000 | -50,327,000 | -38,005,000 | -29,954,000 | -24,195,000 | -22,704,000 | -8,637,000 | 118,172,000 | ||||||||||||||||||||||||||||||
yoy | 16.91% | -11.03% | -2.00% | -70.96% | -47.83% | -42.82% | 18.03% | 88.01% | 94.08% | 37.37% | 22.54% | 23.02% | 36.03% | 32.04% | 27.31% | 13.82% | 8.70% | 8.47% | 7.44% | 22.68% | 39.40% | 98.82% | 142.97% | 121.67% | ||||||||||||||||||||||||||||||||||||
qoq | 55.55% | -47.70% | 141.46% | -40.48% | 18.38% | -42.40% | -28.44% | 6.91% | 29.75% | 18.92% | 13.98% | 10.36% | -8.16% | 6.08% | 14.43% | 22.03% | -10.86% | 2.28% | 2.30% | 16.54% | -11.04% | 1.31% | 16.81% | 32.42% | 26.88% | 23.80% | 6.57% | |||||||||||||||||||||||||||||||||
operating margin % | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | NaN% | -Infinity% | NaN% | NaN% | NaN% | -Infinity% | NaN% | NaN% | NaN% | -Infinity% | NaN% | NaN% | NaN% | -Infinity% | NaN% | NaN% | NaN% | -Infinity% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | -Infinity% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | 0% | 0% | 0% | NaN% | NaN% | NaN% | NaN% | Infinity% | NaN% | NaN% | |
interest income | 8,243,000 | 9,459,000 | 10,308,000 | 8,227,000 | 9,370,000 | 11,079,000 | 13,019,000 | 14,222,000 | 8,334,000 | 8,953,000 | 3,298,000 | 3,551,000 | 3,776,000 | 1,076,000 | 717,000 | 323,000 | 69,000 | 52,000 | 60,000 | 91,000 | 160,000 | 432,000 | 823,000 | 1,204,000 | 1,870,000 | 2,214,000 | 2,766,000 | 3,005,000 | 3,039,000 | 2,821,000 | 1,166,000 | 705,000 | 174,000 | 92,000 | 76,000 | 19,000 | 17,000 | |||||||||||||||||||||||
interest expense | -7,819,000 | -8,297,000 | -7,451,000 | -3,264,000 | -3,297,000 | -3,499,000 | -3,679,000 | -3,656,000 | -3,838,000 | -3,971,000 | -3,504,000 | -2,901,000 | -2,336,000 | -1,682,000 | -1,502,000 | -780,000 | 435,000 | |||||||||||||||||||||||||||||||||||||||||||
other expense | -2,092,000 | -128,000 | -293,000 | -42,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income | -94,391,000 | -58,575,000 | -114,190,000 | -42,281,000 | -73,238,000 | -59,416,000 | -106,964,000 | -151,971,000 | -147,541,000 | -112,194,000 | -98,740,000 | -85,800,000 | -76,896,000 | -85,905,000 | -81,197,000 | -70,730,000 | -57,518,000 | -64,549,000 | -63,100,000 | -61,651,000 | -52,546,000 | -59,123,000 | -57,963,000 | -49,023,000 | -36,135,000 | -27,740,000 | -21,429,000 | -19,699,000 | -15,080,000 | -8,512,000 | -6,460,000 | -6,364,000 | -8,363,000 | -8,347,000 | -5,999,000 | -14,048,740 | -3,379,000 | -6,524,000 | -17,628,000 | -19,800,000 | -20,707,000 | -19,966,000 | -22,286,000 | -23,557,000 | -22,515,000 | -22,787,000 | -20,728,000 | -14,996,000 | -14,620,000 | -15,051,000 | -12,734,000 | -12,502,000 | -11,401,000 | -10,262,000 | -9,074,000 | -9,308,000 | 118,119,000 | |||
yoy | 28.88% | -1.42% | 6.76% | -72.18% | -50.36% | -47.04% | 8.33% | 77.12% | 91.87% | 30.60% | 21.61% | 21.31% | 33.69% | 33.08% | 28.68% | 14.73% | 9.46% | 9.18% | 8.86% | 25.76% | 45.42% | 113.13% | 170.49% | 148.86% | 139.62% | 225.89% | 231.72% | 209.54% | 80.32% | 1.98% | 7.68% | -54.70% | 147.50% | 27.94% | -65.97% | -29.05% | -83.68% | -67.32% | -20.90% | -15.95% | -8.03% | -12.38% | 7.52% | 57.09% | 54.00% | 51.40% | 62.78% | 19.95% | 28.23% | 46.67% | 40.34% | 34.31% | -109.65% | |||||||
qoq | 61.15% | -48.70% | 170.07% | -42.27% | 23.26% | -44.45% | -29.62% | 3.00% | 31.51% | 13.63% | 15.08% | 11.58% | -10.49% | 5.80% | 14.80% | 22.97% | -10.89% | 2.30% | 2.35% | 17.33% | -11.12% | 2.00% | 18.24% | 35.67% | 30.26% | 29.45% | 8.78% | 30.63% | 77.16% | 31.76% | 1.51% | -23.90% | 0.19% | 39.14% | -57.30% | 315.77% | -48.21% | -62.99% | -10.97% | -4.38% | 3.71% | -10.41% | -5.40% | 4.63% | -1.19% | 9.93% | 38.22% | 2.57% | -2.86% | 18.20% | 1.86% | 9.66% | 11.10% | 13.09% | -2.51% | -107.88% | ||||
net income margin % | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | NaN% | -Infinity% | NaN% | NaN% | NaN% | -Infinity% | NaN% | NaN% | NaN% | -Infinity% | NaN% | NaN% | NaN% | -Infinity% | NaN% | NaN% | NaN% | -Infinity% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | -Infinity% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | -10238.78% | -765.26% | -923.34% | -Infinity% | -Infinity% | -Infinity% | -Infinity% | Infinity% | NaN% | NaN% | |
net loss per common, series a preferred and series b preferred share: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted net loss per common, series a preferred, and series b preferred share | -3,250 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted weighted-average number of shares outstanding | 29,032,422,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on extinguishment of debt | -2,779,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net loss per common share: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted net loss per common share | -2,530 | -5,080 | -1,900 | -3,320 | -2,590 | -4,920 | -7,100 | -7,380 | -5,720 | -5,340 | -4,690 | -4,230 | -4,980 | -4,750 | -4,140 | -3,360 | -3,790 | -3,790 | -3,720 | -3,320 | -3,820 | -3,750 | -3,180 | -2,340 | -1,800 | -1,390 | -1,280 | -560 | -450 | -680 | -500 | -1.34 | -250 | |||||||||||||||||||||||||||
basic and diluted weighted-average number of common shares outstanding | 22,434,310,000 | 22,482,502,000 | 22,207,017,000 | 22,091,314,000 | 21,272,962,000 | 21,745,929,000 | 21,402,646,000 | 20,001,569,000 | 18,687,774,000 | 18,476,414,000 | 18,310,952,000 | 18,187,924,000 | 17,137,201,000 | 17,103,395,000 | 17,103,395,000 | 17,103,395,000 | 16,535,188,000 | 16,639,776,000 | 16,571,322,000 | 15,840,401,000 | 15,446,638,000 | 15,448,425,000 | 15,433,348,000 | 15,429,154,000 | 15,394,659,000 | 15,415,096,000 | 15,368,986,000 | 15,364,465,000 | 15,307,872,000 | 14,383,720,000 | 14,127,868,000 | 12,378,622,000 | 12,039,005,000 | 11,955,739,000 | 10,462,182 | 137,397,015,000 | 137,362,260,000 | 135,971,551,000 | 132,295,909,000 | 108,376,264,000 | 105,774,949,000 | 94,046,278,000 | 85,438,127,000 | 69,047,161,000 | 69,034,823,000 | 68,991,371,000 | 60,661,720,000 | 57,650,412,000 | 56,366,992,000 | 42,211,858,000 | 42,166,739,000 | 42,008,818,000 | 40,342,671,000 | 39,451,592,000 | ||||||
total revenues | 147,000 | 1,664,000 | 1,354,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
yoy | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | |||||||||||||||||||||||||||
qoq | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | NaN% | -91.17% | 22.90% | |||||||||||||||||||||||||||||
general and administrative | 46,536,000 | 27,583,000 | 17,845,000 | 16,182,000 | 14,557,000 | 12,141,000 | 11,774,000 | 9,658,000 | 11,712,000 | 8,287,000 | 10,110,000 | 7,209,000 | 6,126,000 | 5,494,000 | 5,639,000 | 4,605,000 | 5,044,000 | 4,748,000 | 7,110,000 | 5,746,000 | 5,122,000 | 2,717,000 | 1,871,000 | 1,955,000 | 1,623,000 | 1,695,000 | 6,285,597 | 3,592,000 | 3,040,000 | 2,981,000 | 3,127,000 | 4,150,000 | 3,241,000 | 2,940,000 | 5,324,000 | 4,171,000 | 4,187,000 | 3,878,000 | 2,796,000 | 2,882,000 | 2,646,000 | 3,131,000 | 2,946,000 | 2,673,000 | 2,591,000 | 2,716,000 | 3,086,000 | 3,149,000 | 3,853,000 | |||||||||||
other income | 273,000 | 100,000 | 200,000 | 100,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income per common share: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted net income per common share | -980 | -450 | -690 | -20 | -50 | -130 | -150 | -190 | -190 | -240 | -280 | -330 | -330 | -300 | -250 | -270 | -300 | -300 | -270 | -220 | -240 | |||||||||||||||||||||||||||||||||||||||
interest income (expense) | 41,778 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on disposal of property and equipment | 91,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
grant revenues | 147,000 | 521,000 | 211,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
collaboration revenues: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
license and milestone revenue | 1,143,000 | 1,143,000 | 1,143,000 | 1,143,000 | 1,143,000 | 1,143,000 | 117,171,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
total collaboration revenues | 1,143,000 | 1,143,000 | 1,143,000 | 3,383,000 | 3,360,000 | 4,023,000 | 130,405,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
license and milestone revenues | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cost sharing reimbursements | 2,240,000 | 2,217,000 | 2,880,000 | 13,234,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restructuring | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other income: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income per common share: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic | -250 | 3,490 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
diluted | -250 | 3,480 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
weighted-average common shares outstanding: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic | 40,382,862,000 | 33,882,760,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
diluted | 40,382,862,000 | 33,904,842,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
research grant revenue | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
in-process research and development | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other compensation expense | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
investment income | 725,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible preferred stock beneficial conversion charge | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible preferred stock dividends | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income attributable to common stockholders | -16,741,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted weighted-average common shares outstanding | 33,390,082,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted net income attributable to common stockholders per share | -0.5 |
Balance Sheets:
Quarterly
Annual
| Unit: USD | 2026-03-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 | 2013-09-30 | 2013-06-30 | 2013-03-31 | 2012-09-30 | 2012-06-30 | 2012-03-31 | 2011-09-30 | 2011-06-30 | 2011-03-31 | 2010-09-30 | 2010-06-30 | 2010-03-31 | 2009-09-30 | 2007-09-30 | 2007-06-30 |
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assets | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current assets: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents | 227,033,000 | 295,694,000 | 186,193,000 | 183,646,000 | 100,019,000 | 232,684,000 | 494,597,000 | 622,517,000 | 99,915,000 | 62,055,000 | 77,196,000 | 113,308,000 | 331,549,000 | 59,340,000 | 53,272,000 | 42,282,000 | 36,269,000 | 49,174,000 | 33,540,000 | 44,205,000 | 54,004,000 | 109,120,000 | 61,867,000 | 66,651,000 | 46,697,000 | 89,486,000 | 72,508,000 | 47,493,000 | 38,046,000 | 264,861,000 | 38,125,000 | 12,960,000 | 34,797,000 | 8,215,000 | 8,393,302 | 10,756,000 | 42,815,000 | 45,537,000 | 32,003,000 | 33,255,000 | 68,478,000 | 96,811,000 | 52,034,000 | 25,477,000 | 33,783,000 | 34,962,000 | 29,442,000 | 25,593,000 | 34,550,000 | 20,643,000 | 25,891,000 | 17,372,000 | 34,906,000 | 42,611,000 | 57,917,000 | 34,803,000 | 64,526,000 | |
restricted cash | 5,155,000 | 5,000,000 | 5,000,000 | 5,000,000 | 5,000,000 | 5,000,000 | 5,000,000 | 83,000 | 83,000 | |||||||||||||||||||||||||||||||||||||||||||||||||
marketable securities | 585,738,000 | 814,055,000 | 610,831,000 | 659,422,000 | 826,232,000 | 765,943,000 | 563,197,000 | 436,546,000 | 534,216,000 | 170,296,000 | 221,222,000 | 216,169,000 | 27,225,000 | 93,852,000 | 158,494,000 | 177,671,000 | 234,077,000 | 249,970,000 | 290,306,000 | 263,019,000 | 230,145,000 | 226,817,000 | 322,513,000 | 341,859,000 | 392,348,000 | 364,124,000 | 393,888,000 | 430,332,000 | 450,492,000 | 225,444,000 | 144,700,000 | 49,177,000 | 32,369,000 | 31,912,000 | 31,164,553 | 32,259,000 | 9,227,000 | 42,715,000 | 66,331,000 | 43,351,000 | 50,802,000 | 15,249,000 | 26,753,000 | 27,907,000 | 36,420,000 | 55,432,000 | 25,697,000 | 19,063,000 | 22,840,000 | 30,017,000 | 36,998,000 | 22,861,000 | 19,215,000 | 6,047,000 | 16,942,000 | |||
trade receivables | 187,356,000 | 113,285,000 | 79,231,000 | 61,428,000 | 53,822,000 | 30,463,000 | 6,899,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||
inventory | 112,070,000 | 69,317,000 | 63,497,000 | 55,241,000 | 34,068,000 | 8,715,000 | 7,072,000 | 854,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||
prepaid expenses and other current assets | 64,955,000 | 49,329,000 | 58,604,000 | 23,242,000 | 13,786,000 | 20,861,000 | 14,963,000 | 14,035,000 | 3,150,000 | 3,118,000 | 3,177,000 | 1,807,000 | 2,595,000 | 3,920,000 | 2,780,000 | 1,217,000 | 1,338,000 | 3,812,000 | 2,221,000 | 822,000 | 1,014,000 | 1,664,000 | 2,223,000 | 976,000 | 1,152,000 | 1,712,000 | 2,389,000 | 565,000 | 767,000 | 968,000 | 374,000 | 583,000 | 781,000 | 225,000 | 1,632,783 | 1,820,000 | 554,000 | 1,975,000 | 2,213,000 | 1,367,000 | 2,911,000 | 2,264,000 | 1,605,000 | 1,358,000 | 1,637,000 | 1,475,000 | 803,000 | 839,000 | 608,000 | 1,362,000 | 832,000 | 524,000 | 682,000 | 721,000 | 1,011,000 | 1,112,000 | 1,315,000 | |
total current assets | 1,182,307,000 | 1,346,680,000 | 1,003,356,000 | 987,979,000 | 1,032,927,000 | 1,063,666,000 | 1,091,728,000 | 1,073,952,000 | 637,281,000 | 235,469,000 | 301,595,000 | 331,284,000 | 361,369,000 | 157,112,000 | 214,546,000 | 221,170,000 | 271,684,000 | 302,956,000 | 326,067,000 | 308,046,000 | 285,163,000 | 337,601,000 | 386,603,000 | 409,486,000 | 440,197,000 | 455,322,000 | 468,785,000 | 478,390,000 | 489,305,000 | 491,273,000 | 183,199,000 | 62,720,000 | 67,947,000 | 40,352,000 | 41,190,638 | 44,835,000 | 52,596,000 | 90,227,000 | 100,547,000 | 77,973,000 | 122,191,000 | 114,324,000 | 80,392,000 | 54,742,000 | 71,840,000 | 91,869,000 | 55,942,000 | 45,495,000 | 57,998,000 | 52,022,000 | 63,721,000 | 40,757,000 | 54,803,000 | 49,379,000 | 58,928,000 | 52,940,000 | 65,924,000 | |
property and equipment | 8,035,000 | 2,913,000 | 1,615,000 | 1,901,000 | 2,190,000 | 2,268,000 | 1,695,000 | 1,742,000 | 1,553,000 | 659,000 | 455,000 | 512,000 | 601,000 | 701,000 | 789,000 | 796,000 | 851,000 | 844,000 | 891,000 | 978,000 | 1,047,000 | 1,153,000 | 1,265,000 | 1,373,000 | 1,184,000 | 181,000 | 211,000 | 240,000 | 244,000 | 255,000 | 279,000 | 111,000 | 120,000 | 5,000 | 1,476 | 103,000 | 374,000 | 561,000 | 714,000 | 855,000 | 1,134,000 | 1,264,000 | 1,408,000 | 1,488,000 | 1,620,000 | 1,350,000 | 1,205,000 | 1,166,000 | 1,324,000 | 1,316,000 | 1,403,000 | 1,752,000 | 2,617,000 | 3,020,000 | 3,463,000 | 4,554,000 | 5,589,000 | |
intangible assets | 7,284,000 | 7,477,000 | 4,548,000 | 4,639,000 | 4,729,000 | 4,819,000 | 4,910,000 | 5,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||
operating lease right-of-use assets | 6,203,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other noncurrent assets | 23,498,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total assets | 1,227,327,000 | 1,362,457,000 | 1,015,381,000 | 996,629,000 | 1,042,247,000 | 1,073,265,000 | 1,099,789,000 | 1,082,280,000 | 640,547,000 | 237,964,000 | 302,461,000 | 332,449,000 | 362,572,000 | 158,644,000 | 216,392,000 | 222,662,000 | 273,332,000 | 304,697,000 | 327,955,000 | 309,731,000 | 286,995,000 | 339,617,000 | 388,388,000 | 411,457,000 | 442,056,000 | 456,254,000 | 469,822,000 | 479,560,000 | 489,549,000 | 491,528,000 | 183,478,000 | 62,831,000 | 68,067,000 | 40,357,000 | 41,507,184 | 44,938,000 | 52,970,000 | 91,014,000 | 101,539,000 | 79,392,000 | 123,656,000 | 115,946,000 | 82,184,000 | 56,663,000 | 73,924,000 | 93,700,000 | 57,613,000 | 47,164,000 | 59,841,000 | 53,868,000 | 65,621,000 | 42,926,000 | 57,881,000 | 52,550,000 | 62,542,000 | 57,562,000 | 71,600,000 | |
liabilities and stockholders’ equity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current liabilities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts payable | 60,801,000 | 44,941,000 | 37,975,000 | 42,056,000 | 43,599,000 | 45,966,000 | 8,994,000 | 21,528,000 | 28,041,000 | 16,542,000 | 17,534,000 | 12,128,000 | 23,831,000 | 18,562,000 | 11,294,000 | 22,780,000 | 21,380,000 | 10,418,000 | 1,067,000 | 4,396,000 | 1,017,000 | 6,277,000 | 5,004,000 | 1,115,000 | 1,178,000 | 773,000 | 446,000 | 4,376,000 | 1,031,000 | 588,000 | 1,420,000 | 1,400,000 | 1,285,000 | 2,780,000 | 1,159,836 | 680,000 | 744,000 | 1,424,000 | 3,018,000 | 3,738,000 | 4,442,000 | 5,226,000 | 5,810,000 | 5,693,000 | 5,222,000 | 5,719,000 | 3,690,000 | 3,468,000 | 3,040,000 | 2,921,000 | 1,999,000 | 1,691,000 | 2,393,000 | 1,280,000 | 1,462,000 | 4,536,000 | 1,981,000 | |
accrued liabilities | 275,761,000 | 345,382,000 | 157,479,000 | 124,165,000 | 124,695,000 | 131,003,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
operating lease liabilities | 1,697,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total current liabilities | 338,259,000 | 391,406,000 | 196,503,000 | 167,237,000 | 169,277,000 | 177,847,000 | 125,162,000 | 114,341,000 | 118,548,000 | 99,665,000 | 99,706,000 | 98,348,000 | 115,894,000 | 98,920,000 | 84,009,000 | 76,635,000 | 76,838,000 | 69,325,000 | 56,710,000 | 48,791,000 | 46,557,000 | 49,365,000 | 45,275,000 | 25,703,000 | 25,130,000 | 15,464,000 | 12,316,000 | 10,456,000 | 6,642,000 | 5,436,000 | 6,294,000 | 8,523,000 | 6,436,000 | 5,906,000 | 3,915,390 | 3,364,000 | 8,639,000 | 30,633,000 | 32,525,000 | 30,920,000 | 32,961,000 | 32,666,000 | 32,365,000 | 25,931,000 | 20,071,000 | 16,551,000 | 18,965,000 | 18,254,000 | 15,644,000 | 17,116,000 | 15,349,000 | 17,314,000 | 14,948,000 | 12,267,000 | 13,037,000 | 17,759,000 | 15,871,000 | |
long term liabilities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loan payable, net of discount | 340,330,000 | 339,753,000 | 118,376,000 | 118,005,000 | 117,569,000 | 117,087,000 | 116,607,000 | 116,135,000 | 115,480,000 | 114,727,000 | 99,249,000 | 83,965,000 | 49,289,000 | 48,983,000 | 48,670,000 | |||||||||||||||||||||||||||||||||||||||||||
operating lease liabilities, net of current portion | 5,284,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total long term liabilities | 345,614,000 | 345,319,000 | 122,900,000 | 118,755,000 | 118,587,000 | 118,263,000 | 117,507,000 | 117,180,000 | 116,666,000 | 116,050,000 | 99,249,000 | 83,965,000 | 49,289,000 | 49,054,000 | 48,848,000 | 283,000 | 387,000 | 491,000 | 594,000 | 387,000 | 468,000 | 548,000 | 197,000 | 279,000 | 361,000 | 441,000 | 520,000 | 598,000 | ||||||||||||||||||||||||||||||
total liabilities | 683,873,000 | 736,725,000 | 319,403,000 | 285,992,000 | 287,864,000 | 296,110,000 | 242,669,000 | 231,521,000 | 235,214,000 | 215,715,000 | 198,955,000 | 182,313,000 | 165,183,000 | 147,974,000 | 132,857,000 | 76,918,000 | 77,225,000 | 69,816,000 | 57,304,000 | 49,178,000 | 47,025,000 | 49,913,000 | 45,472,000 | 25,982,000 | 25,491,000 | 15,905,000 | 12,836,000 | 11,054,000 | 6,642,000 | 5,436,000 | 6,294,000 | 8,523,000 | 6,436,000 | 5,906,000 | 3,915,390 | 3,364,000 | 8,639,000 | 30,644,000 | 32,557,000 | 33,252,000 | 39,928,000 | 41,948,000 | 43,960,000 | 42,051,000 | 38,488,000 | 37,096,000 | 25,423,000 | 26,700,000 | 26,071,000 | 29,287,000 | 29,184,000 | 29,825,000 | 31,620,000 | 17,031,000 | 19,153,000 | 26,726,000 | 19,139,000 | |
stockholders’ equity: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, par value 0.0001... | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
common stock, par value 0.0001... | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 2,000 | 1,000 | 1,000 | 1,000 | 1,000 | 1,157 | 14,000 | 14,000 | 14,000 | 13,000 | 11,000 | 11,000 | 10,000 | 9,000 | 7,000 | 7,000 | 7,000 | 6,000 | 6,000 | 6,000 | 5,000 | 5,000 | 4,000 | 4,000 | 4,000 | 4,000 | 3,000 | ||
additional paid-in-capital | 2,727,227,000 | 2,656,553,000 | 2,612,566,000 | 2,585,666,000 | 2,556,095,000 | 2,518,648,000 | 2,493,288,000 | 2,334,760,000 | 1,741,153,000 | 1,246,385,000 | 1,228,949,000 | 1,189,776,000 | 1,160,079,000 | 887,660,000 | 879,538,000 | 870,972,000 | 863,495,000 | 837,636,000 | 810,295,000 | 738,575,000 | 665,385,000 | 655,622,000 | 650,211,000 | 644,413,000 | 639,567,000 | 635,535,000 | 630,550,000 | 622,678,000 | 610,845,000 | 605,418,000 | 290,182,000 | 152,276,000 | 151,247,000 | 115,692,000 | 105,161,301 | 757,626,000 | 757,081,000 | 756,053,000 | 747,055,000 | 704,403,000 | 700,927,000 | 671,240,000 | 613,180,000 | 541,849,000 | 540,155,000 | 538,538,000 | 475,273,000 | 448,555,000 | 447,226,000 | 412,262,000 | 411,375,000 | 375,545,000 | 368,482,000 | 367,480,000 | 366,276,000 | 337,376,000 | ||
accumulated other comprehensive income | 1,082,000 | 1,068,000 | 1,111,000 | 389,000 | 468,000 | 1,271,000 | -368,000 | -172,000 | 468,000 | 47,000 | 36,000 | 64,000 | 81,000 | 4,000 | 11,000 | 6,000 | 11,000 | 3,000 | 4,000 | 6,000 | 9,000 | 7,000 | 8,000 | 4,000 | 19,000 | 1,000 | 10,000 | 3,000 | 2,000 | 3,000 | ||||||||||||||||||||||||||||
accumulated deficit | -2,184,857,000 | -2,031,891,000 | -1,917,701,000 | -1,875,420,000 | -1,802,182,000 | -1,742,766,000 | -1,635,802,000 | -1,483,831,000 | -1,336,290,000 | -1,224,096,000 | -1,125,356,000 | -1,039,556,000 | -962,660,000 | -876,755,000 | -795,558,000 | -724,828,000 | -667,310,000 | -602,761,000 | -539,661,000 | -478,010,000 | -425,464,000 | -366,341,000 | -308,378,000 | -259,355,000 | -223,220,000 | -195,480,000 | -174,051,000 | -98,016,000 | ||||||||||||||||||||||||||||||
total stockholders’ equity | 543,454,000 | 625,732,000 | 695,978,000 | 710,637,000 | 754,383,000 | 777,155,000 | 857,120,000 | 850,759,000 | 405,333,000 | 22,249,000 | 103,506,000 | 150,136,000 | 197,389,000 | 10,670,000 | 83,535,000 | 145,744,000 | 196,107,000 | 234,881,000 | 270,651,000 | 260,553,000 | 239,970,000 | 289,704,000 | 342,916,000 | 385,475,000 | 416,565,000 | 440,349,000 | 456,986,000 | 468,506,000 | 482,907,000 | 486,092,000 | 177,184,000 | 54,308,000 | 61,631,000 | 34,451,000 | 37,591,794 | 41,574,000 | 44,331,000 | 60,370,000 | 68,982,000 | 46,140,000 | 83,728,000 | 73,998,000 | 38,224,000 | 14,612,000 | 35,436,000 | 56,604,000 | 32,190,000 | 20,464,000 | 33,770,000 | 24,581,000 | 36,437,000 | 13,101,000 | 26,261,000 | 35,519,000 | 43,389,000 | 30,836,000 | 52,461,000 | |
total liabilities and stockholders’ equity | 1,227,327,000 | 1,362,457,000 | 1,015,381,000 | 996,629,000 | 1,042,247,000 | 1,073,265,000 | 1,099,789,000 | 1,082,280,000 | 640,547,000 | 237,964,000 | 302,461,000 | 332,449,000 | 362,572,000 | 158,644,000 | 216,392,000 | 222,662,000 | 273,332,000 | 304,697,000 | 327,955,000 | 309,731,000 | 286,995,000 | 339,617,000 | 388,388,000 | 411,457,000 | 442,056,000 | 456,254,000 | 469,822,000 | 479,560,000 | 489,549,000 | 491,528,000 | 183,478,000 | 62,831,000 | 68,067,000 | 40,357,000 | 41,507,184 | 44,938,000 | 52,970,000 | 91,014,000 | 101,539,000 | 79,392,000 | 123,656,000 | 115,946,000 | 82,184,000 | 56,663,000 | 73,924,000 | 93,700,000 | 57,613,000 | 47,164,000 | 59,841,000 | 53,868,000 | 65,621,000 | 42,926,000 | 57,881,000 | 52,550,000 | 62,542,000 | 57,562,000 | 71,600,000 | |
right-of-use asset | 5,387,000 | 5,862,000 | 2,110,000 | 2,401,000 | 2,512,000 | 1,456,000 | 1,586,000 | 1,713,000 | 1,836,000 | 411,000 | 653,000 | 602,000 | 831,000 | 1,057,000 | 696,000 | 797,000 | 897,000 | 997,000 | 707,000 | 785,000 | 863,000 | 520,000 | 598,000 | 675,000 | 751,000 | 826,000 | 930,000 | |||||||||||||||||||||||||||||||
lease liability | 1,083,000 | 1,049,000 | 1,016,000 | 983,000 | 878,000 | 557,000 | 542,000 | 527,000 | 513,000 | 411,000 | 653,000 | 602,000 | 760,000 | 879,000 | 413,000 | 410,000 | 406,000 | 403,000 | 320,000 | 318,000 | 315,000 | 323,000 | 319,000 | 315,000 | 310,000 | 306,000 | 302,000 | |||||||||||||||||||||||||||||||
accrued expenses | 115,611,000 | 92,271,000 | 89,980,000 | 82,610,000 | 81,761,000 | 85,567,000 | 91,461,000 | 79,598,000 | 71,836,000 | 53,442,000 | 55,048,000 | 58,501,000 | 55,240,000 | 44,075,000 | 45,222,000 | 42,773,000 | 39,948,000 | 24,269,000 | 23,637,000 | 14,381,000 | 11,564,000 | 5,778,000 | 5,611,000 | 4,848,000 | 4,874,000 | 7,123,000 | 5,151,000 | 3,126,000 | 2,755,554 | 9,619,000 | ||||||||||||||||||||||||||||
accumulated other comprehensive loss | -42,000 | -89,000 | -86,000 | -32,000 | -237,000 | -447,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive gain | -402,000 | -80,000 | 4,000 | 15,000 | -14,000 | 47,000 | 421,000 | 1,081,000 | 415,000 | 216,000 | 292,000 | 485,000 | 178,000 | |||||||||||||||||||||||||||||||||||||||||||||
other receivable — related party | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
goodwill and other intangibles assets | 315,070 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities and stockholders’ deficit | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible promissory notes payable — related parties | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
advances payable — related party | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued interest on advances — related party | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued contract research costs | 1,202,000 | 2,737,000 | 17,206,000 | 14,728,000 | 12,511,000 | 14,276,000 | 12,987,000 | 12,488,000 | 8,352,000 | 5,911,000 | 4,901,000 | 3,719,000 | 3,776,000 | 4,007,000 | 3,010,000 | 2,871,000 | 3,253,000 | 2,726,000 | 2,535,000 | 2,591,000 | 2,854,000 | |||||||||||||||||||||||||||||||||||||
other accrued liabilities | 1,450,000 | 2,826,000 | 5,047,000 | 5,529,000 | 5,408,000 | 4,994,000 | 5,212,000 | 4,765,000 | 4,497,000 | 3,624,000 | 2,839,000 | 3,643,000 | 3,119,000 | 2,530,000 | 3,249,000 | 2,909,000 | 2,152,000 | 3,313,000 | 2,802,000 | 3,226,000 | 4,125,000 | |||||||||||||||||||||||||||||||||||||
current portion of capital lease obligations | 22,000 | 33,000 | 43,000 | 43,000 | 42,000 | 42,000 | 41,000 | 41,000 | 4,000 | 8,000 | 11,000 | 13,000 | ||||||||||||||||||||||||||||||||||||||||||||||
current portion of term loans | 10,000 | 2,299,000 | 6,913,000 | 9,207,000 | 9,221,000 | 9,207,000 | 9,200,000 | 9,261,000 | 7,385,000 | 5,306,000 | 3,081,000 | 7,900,000 | 7,878,000 | 6,055,000 | 4,613,000 | 3,093,000 | 5,529,000 | |||||||||||||||||||||||||||||||||||||||||
other assets | 226,000 | 278,000 | 564,000 | 331,000 | 358,000 | 384,000 | 433,000 | 464,000 | 481,000 | 466,000 | 503,000 | 519,000 | 530,000 | 497,000 | 417,000 | 461,000 | 151,000 | 151,000 | 68,000 | 87,000 | ||||||||||||||||||||||||||||||||||||||
long-term liabilities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
capital lease obligations, net of current portion | 11,000 | 22,000 | 33,000 | 54,000 | 65,000 | 75,000 | 4,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||
term loans, net of current portion | 10,000 | 2,299,000 | 6,913,000 | 9,217,000 | 11,520,000 | 16,120,000 | 18,417,000 | 20,545,000 | 6,454,000 | 8,438,000 | 10,416,000 | 12,154,000 | 13,815,000 | 11,471,000 | ||||||||||||||||||||||||||||||||||||||||||||
total long-term liabilities | 11,000 | 32,000 | 2,332,000 | 6,967,000 | 9,282,000 | 11,595,000 | 16,120,000 | 18,417,000 | 20,545,000 | 6,458,000 | 8,446,000 | 10,427,000 | 12,171,000 | 13,835,000 | 12,511,000 | 16,672,000 | 4,764,000 | 6,116,000 | 8,967,000 | |||||||||||||||||||||||||||||||||||||||
capital lease obligations | 13,000 | 12,000 | 20,000 | 31,000 | 117,000 | 277,000 | 1,078,000 | 1,185,000 | 1,352,000 | |||||||||||||||||||||||||||||||||||||||||||||||||
collaboration receivable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred collaboration revenue | 3,303,000 | 4,446,000 | 4,572,000 | 4,572,000 | 4,572,000 | 4,573,000 | 4,892,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||
term loan | 1,667,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred collaboration revenue—long-term | 7,875,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
collaboration payable—long-term | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
capital lease obligations—long-term | 1,092,000 | 3,268,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ equity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
authorized: 5,000,000 shares at september 30, 2009 and december 31, 2008; no shares issued and outstanding at september 30, 2009 and december 31, 2008 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
authorized: 100,000,000 shares at september 30, 2009 and december 31, 2008; 33,978,300 and 33,919,584 shares issued and outstanding at september 30, 2009 and december 31, 2008, respectively | 3,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders' equity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
marketable securities available-for-sale | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred offering costs | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
capital lease obligations—current | 2,440,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other current liabilities | 1,831,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenue | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible preferred stock, at redemption value: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
series a convertible preferred stock, 0.0001 par value per share... | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
additional paid-in capital | 322,111,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deficit accumulated during the development stage |
Cashflow Statements:
Quarterly
Annual
| Unit: USD | 2026-03-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 | 2013-09-30 | 2013-06-30 | 2013-03-31 | 2012-09-30 | 2012-06-30 | 2012-03-31 | 2011-09-30 | 2011-06-30 | 2011-03-31 | 2010-09-30 | 2010-06-30 | 2010-03-31 | 2009-09-30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cash flows from operating activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net loss | -94,391,000 | -114,190,000 | -42,281,000 | -73,238,000 | -151,971,000 | -147,541,000 | -112,194,000 | -98,740,000 | -85,800,000 | -76,896,000 | -85,905,000 | -81,197,000 | -70,730,000 | -57,518,000 | -64,549,000 | -63,100,000 | -61,651,000 | -52,546,000 | -59,123,000 | -57,963,000 | -49,023,000 | -36,135,000 | -27,740,000 | -21,429,000 | -19,699,000 | -15,080,000 | -8,512,000 | -6,460,000 | -6,364,000 | -8,363,000 | -8,347,000 | -5,999,000 | -8,735,589 | -3,379,000 | -6,524,000 | -17,628,000 | -19,800,000 | -20,707,000 | -19,966,000 | -22,286,000 | -23,557,000 | |||||||||||||||
adjustments to reconcile net loss to net cash from operating activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stock-based compensation expense | 34,018,000 | 26,252,000 | 25,159,000 | 20,931,000 | 17,676,000 | 17,898,000 | 24,404,000 | 19,902,000 | 14,852,000 | 12,660,000 | 10,973,000 | 11,250,000 | 8,082,000 | 8,122,000 | 7,944,000 | 7,477,000 | 6,356,000 | 6,242,000 | 8,179,000 | 6,096,000 | 5,134,000 | 5,061,000 | 5,689,000 | 4,846,000 | 4,032,000 | 4,950,000 | 7,755,000 | 6,022,000 | 4,976,000 | 2,227,000 | 1,167,000 | 1,029,000 | 676,000 | 602,000 | 545,000 | 448,000 | 1,168,000 | 843,000 | 1,710,000 | 1,566,000 | 1,513,000 | 2,586,000 | 1,683,000 | 1,591,000 | 1,216,000 | 801,000 | 731,000 | 827,000 | 867,000 | 812,000 | 827,000 | 963,000 | 1,135,000 | 1,087,000 | ||
depreciation and amortization expense | 386,000 | 358,000 | 377,000 | 379,000 | 363,000 | 298,000 | 267,000 | 168,000 | 142,000 | 135,000 | 126,000 | 124,000 | 129,000 | 121,000 | 110,000 | 107,000 | 106,000 | 97,000 | 89,000 | 113,000 | 116,000 | 115,000 | 115,000 | 125,000 | 28,000 | 28,000 | 28,000 | 28,000 | 24,000 | 24,000 | 23,000 | 9,000 | ||||||||||||||||||||||||
amortization of debt issuance costs and discount | 449,000 | 329,000 | 371,000 | 436,000 | 482,000 | 480,000 | 472,000 | 655,000 | 753,000 | 674,000 | 554,000 | 433,000 | 306,000 | 313,000 | ||||||||||||||||||||||||||||||||||||||||||
amortization and interest accretion related to operating leases | 408,000 | 1,551,000 | 55,000 | 56,000 | 58,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||
other non-cash items | -2,440,000 | -330,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
changes in operating assets and liabilities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
trade receivables | -52,880,000 | -34,054,000 | -17,803,000 | -7,606,000 | -23,359,000 | -23,564,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||
prepaid expenses and other assets | -40,649,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
inventory | -22,187,000 | -5,820,000 | -8,256,000 | -21,173,000 | -25,353,000 | -1,643,000 | -6,218,000 | -854,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
accounts payable | 3,584,000 | 5,961,000 | -4,081,000 | -1,543,000 | -2,367,000 | 36,972,000 | -7,534,000 | -11,513,000 | 11,499,000 | -992,000 | 5,406,000 | -11,703,000 | 5,269,000 | 7,268,000 | -11,486,000 | 1,400,000 | 10,962,000 | 9,351,000 | -3,329,000 | 3,379,000 | -5,260,000 | 1,273,000 | 3,889,000 | -63,000 | 405,000 | 327,000 | -3,930,000 | 1,889,000 | 115,000 | -1,495,000 | 2,018,000 | 598,000 | 58,000 | 222,000 | 923,000 | |||||||||||||||||||||
accrued liabilities | 4,287,000 | 187,537,000 | 33,314,000 | -530,000 | -6,308,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||
accrued interest, net of interest received on maturity of investments | 1,980,000 | 202,000 | 513,000 | 2,853,000 | -13,337,000 | 503,000 | -9,878,000 | -1,380,000 | -2,323,000 | 435,000 | -1,393,000 | -2,169,000 | 416,000 | -318,000 | -207,000 | 106,000 | 53,000 | 184,000 | 65,000 | 485,000 | 1,086,000 | 280,000 | 640,000 | -86,000 | 2,073,000 | 1,306,000 | ||||||||||||||||||||||||||||||
net cash from operating activities | -167,435,000 | 79,850,000 | -47,052,000 | -88,891,000 | -104,486,000 | -66,984,000 | -134,945,000 | -149,157,000 | -79,933,000 | -84,920,000 | -75,310,000 | -84,067,000 | -58,515,000 | -59,069,000 | -57,360,000 | -49,913,000 | -48,051,000 | -45,556,000 | -46,881,000 | -43,429,000 | -54,947,000 | -47,850,000 | -24,258,000 | -30,506,000 | -12,282,000 | -11,324,000 | ||||||||||||||||||||||||||||||
capital expenditures | -870,000 | 0 | 0 | -195,000 | -779,000 | -131,000 | -357,000 | -1,036,000 | -339,000 | -69,000 | -35,000 | -29,000 | -33,000 | -103,000 | -52,000 | -113,000 | -50,000 | -2,000 | -44,000 | -10,000 | -3,000 | -7,000 | -314,000 | -134,000 | 2,000 | |||||||||||||||||||||||||||||||
free cash flows | -168,305,000 | 79,850,000 | -47,052,000 | -104,681,000 | -67,763,000 | -135,076,000 | -149,514,000 | -80,969,000 | -85,259,000 | -75,379,000 | -84,102,000 | -58,544,000 | -59,102,000 | -57,463,000 | -49,965,000 | -48,164,000 | -45,606,000 | -46,883,000 | -43,473,000 | -54,957,000 | -47,853,000 | -24,265,000 | -30,820,000 | -12,416,000 | -11,322,000 | |||||||||||||||||||||||||||||||
cash flows from investing activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of marketable securities | -157,829,000 | -478,208,000 | -225,534,000 | -130,812,000 | -350,186,000 | -416,033,000 | -280,791,000 | -84,197,000 | -474,890,000 | -68,853,000 | -91,874,000 | -198,822,000 | -12,785,000 | -14,197,000 | -78,929,000 | -37,567,000 | -54,749,000 | -115,300,000 | -130,349,000 | -93,722,000 | -116,156,000 | -59,317,000 | -95,222,000 | -58,647,000 | -212,230,000 | -140,957,000 | ||||||||||||||||||||||||||||||
sales and maturities of marketable securities | 353,869,000 | 275,069,000 | 273,392,000 | 294,690,000 | 302,431,000 | 214,421,000 | 163,824,000 | 182,607,000 | 113,803,000 | 119,391,000 | 88,211,000 | 11,993,000 | 79,201,000 | 79,367,000 | 98,268,000 | 93,545,000 | 70,505,000 | 155,441,000 | 103,026,000 | 60,302,000 | 111,368,000 | 154,073,000 | 114,594,000 | 109,421,000 | 181,857,000 | 169,222,000 | 128,716,000 | 170,387,000 | 51,051,000 | 48,763,000 | 20,071,000 | -13,089,000 | 8,470,000 | 11,563,000 | -32,246,154 | 37,186,000 | 15,717,000 | |||||||||||||||||||
purchases of property and equipment, net of disposals | -3,849,000 | -195,000 | -779,000 | -131,000 | -357,000 | -1,036,000 | -339,000 | -69,000 | -35,000 | -29,000 | -33,000 | -103,000 | -52,000 | -113,000 | -50,000 | -2,000 | -44,000 | -10,000 | -3,000 | -7,000 | -314,000 | -134,000 | 2,000 | |||||||||||||||||||||||||||||||||
net cash from investing activities | 192,191,000 | -206,996,000 | 47,858,000 | 163,878,000 | -47,950,000 | -202,391,000 | -122,098,000 | 98,053,000 | -362,123,000 | 50,199,000 | -3,732,000 | -186,864,000 | 66,387,000 | 65,137,000 | 19,236,000 | 55,926,000 | 15,643,000 | 40,091,000 | -27,325,000 | -33,464,000 | -4,798,000 | 94,753,000 | 19,365,000 | 50,460,000 | -30,507,000 | 28,267,000 | 8,317,000 | 11,478,000 | 16,197,000 | -8,262,000 | ||||||||||||||||||||||||||
cash flows from financing activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from exercise of common stock options | 2,329,000 | 83,000 | 451,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash from financing activities | 2,329,000 | 236,647,000 | 1,741,000 | 8,640,000 | 19,771,000 | 7,462,000 | 134,123,000 | 573,706,000 | 479,916,000 | 19,580,000 | 42,930,000 | 52,690,000 | 264,337,000 | 0 | 19,503,000 | 21,099,000 | 63,541,000 | 67,094,000 | 4,629,000 | 350,000 | 0 | 35,000 | 25,815,000 | 54,173,000 | 7,617,000 | -211,000 | 120,000 | 12,280,000 | 23,951,000 | 441,000 | 33,050,000 | -135,000 | 34,837,000 | 2,103,000 | 13,956,000 | -247,000 | 26,351,000 | |||||||||||||||||||
effect of exchange rate changes on cash, cash equivalents and restricted cash | 1,320,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
net increase in cash, cash equivalents, and restricted cash | 28,405,000 | 109,501,000 | 2,547,000 | 83,627,000 | -261,913,000 | -122,920,000 | 522,602,000 | |||||||||||||||||||||||||||||||||||||||||||||||||
cash, cash equivalents, and restricted cash at beginning of period | 203,783,000 | 0 | 0 | 105,019,000 | 0 | 0 | 0 | 99,915,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
cash, cash equivalents, and restricted cash at end of period | 232,188,000 | 109,501,000 | 2,547,000 | 188,646,000 | -132,665,000 | -261,913,000 | -122,920,000 | 622,517,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
supplemental disclosure of cash flow information: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
obtaining an operating lease right-of-use asset in exchange for an operating lease liability | 1,672,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of property and equipment in accounts payable | 2,979,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on extinguishment of debt | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
prepaid expenses and other current assets | 9,275,000 | -35,362,000 | -9,456,000 | 7,075,000 | -5,898,000 | -928,000 | -10,885,000 | -32,000 | 59,000 | -1,370,000 | 788,000 | 1,325,000 | -1,140,000 | -1,563,000 | 121,000 | 2,474,000 | -1,591,000 | -1,399,000 | 191,000 | 651,000 | 559,000 | -1,247,000 | 175,000 | 561,000 | 677,000 | -1,794,000 | 888,000 | 290,000 | 287,000 | -517,000 | 520,000 | 647,000 | 289,000 | 153,000 | ||||||||||||||||||||||
acquisition of intangible asset | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of debt | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payment of debt issuance costs | 0 | -75,000 | -75,000 | -213,000 | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||
repayment of debt | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuances of stock, excluding related parties, net of transaction costs | 8,640,000 | -23,000 | 0 | 85,949,000 | 311,561,000 | 235,703,000 | 2,730,000 | 18,958,000 | 21,092,000 | 63,541,000 | 66,616,000 | |||||||||||||||||||||||||||||||||||||||||||||
proceeds from related parties - warrants, exercise of common stock options, net of transaction costs | 17,735,000 | 19,794,000 | 7,462,000 | 48,174,000 | 262,145,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||
obtaining a right-of-use asset in exchange for a lease liability | 0 | 162,000 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||
debt issuance costs in accounts payable and accrued expenses | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
intangible assets in accounts payable at the end of the period | 5,000,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of loan payable | 0 | 15,000,000 | 15,000,000 | 35,000,000 | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||
net increase in cash and cash equivalents | 37,860,000 | -15,141,000 | -36,112,000 | -218,241,000 | 272,209,000 | 6,068,000 | 10,990,000 | 6,013,000 | -12,905,000 | 15,634,000 | -10,665,000 | -9,799,000 | -55,116,000 | 47,253,000 | -4,784,000 | 19,954,000 | -42,789,000 | 16,978,000 | -28,333,000 | 44,777,000 | 3,544,000 | 4,475,000 | 13,762,000 | |||||||||||||||||||||||||||||||||
net income | -22,787,000 | -20,728,000 | -15,051,000 | -12,734,000 | -12,502,000 | -11,401,000 | -10,262,000 | -9,074,000 | -9,308,000 | 119,220,000 | ||||||||||||||||||||||||||||||||||||||||||||||
adjustments to reconcile net income to net cash from operating activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued expense | 23,340,000 | 2,291,000 | 7,370,000 | 849,000 | -3,806,000 | -5,894,000 | 11,863,000 | 7,762,000 | 18,394,000 | -1,606,000 | -3,453,000 | 3,261,000 | 11,165,000 | -1,147,000 | 15,679,000 | 632,000 | 8,359,000 | 2,817,000 | 1,972,000 | |||||||||||||||||||||||||||||||||||||
proceeds from the sale of related party warrants and stock and exercise of common stock options, net of transaction costs | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents at beginning of period | 0 | 0 | 0 | 331,549,000 | 0 | 0 | 0 | 36,269,000 | 0 | 0 | 0 | 54,004,000 | 0 | 0 | 0 | 46,697,000 | 0 | 0 | 0 | 57,379,000 | 0 | 0 | 148,627,000 | 0 | 0 | 19,145,000 | -34,659,751 | 0 | 34,966,000 | 0 | 0 | 46,024,000 | 0 | 0 | 48,490,000 | 0 | 0 | 81,512,000 | 0 | 0 | 30,075,000 | 0 | 0 | 31,310,000 | 0 | 0 | 44,155,000 | 18,358,000 | ||||||||
cash and cash equivalents at end of period | 37,860,000 | -15,141,000 | -36,112,000 | 113,308,000 | 272,209,000 | 6,068,000 | 10,990,000 | 42,282,000 | -12,905,000 | 15,634,000 | -10,665,000 | 44,205,000 | -55,116,000 | 47,253,000 | -4,784,000 | 66,651,000 | -42,789,000 | 16,978,000 | 25,015,000 | 47,493,000 | -226,815,000 | 226,736,000 | 38,125,000 | -21,837,000 | 26,582,000 | 8,215,000 | -2,362,698 | -32,059,000 | 42,815,000 | 13,534,000 | -1,252,000 | 33,255,000 | -28,333,000 | 44,777,000 | 52,034,000 | -8,306,000 | -1,179,000 | 34,962,000 | 3,849,000 | -8,957,000 | 34,550,000 | -5,248,000 | 8,519,000 | 17,372,000 | -7,705,000 | -15,306,000 | 57,917,000 | -29,723,000 | ||||||||
proceeds from the sale of related party stock and exercise of common stock options, net of transaction costs | 1,925,000 | 6,251,000 | 17,903,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from the exercise of common stock options | 7,000 | 35,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of property and equipment in accounts payable at period end | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from the exercise of common stock options, net of transaction costs | 478,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued expenses | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of property and equipment in accounts payable or accrued expense at period end | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash provided by financing activities | 83,000 | 313,009,000 | 265,000 | 0 | 34,879,000 | 3,399,000 | 5,516,000 | |||||||||||||||||||||||||||||||||||||||||||||||||
net decrease in cash and cash equivalents | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
acquisition of a right-of-use asset in exchange for a lease liability | 900,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of stock, net of transaction costs | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of stock, net of transaction costs, including exercise of common stock options | 265,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
pik interest expense on convertible promissory notes payable — related parties | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts receivable - related parties | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued interest — related party | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash received from merger transaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of property and equipment | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net proceeds from the sale of property, equipment and other assets | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash provided (used) in investing activities | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock, net of transaction costs | 3,399,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from convertible notes — related parties | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net increase (decrease) in cash and cash equivalents | 7,849,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
exchange of related party advances payable for convertible notes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
related party debt restructuring | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common and preferred stock, net of transaction costs | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stock-based compensation expense and share based payments | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other receivable — related parties | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
prepaid expense | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net proceeds from the sale of property and equipment | 216,440 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash provided by in investing activities | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from advances—related party | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
supplemental disclosure of non-cash financing activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
depreciation and amortization | 96,000 | 46,000 | 166,000 | 168,000 | 169,000 | 167,000 | 169,000 | 168,000 | 148,000 | 125,000 | 100,000 | 170,000 | 223,000 | 230,000 | 350,000 | 384,000 | 439,000 | 473,000 | 482,000 | 515,000 | 302,000 | |||||||||||||||||||||||||||||||||||
gain on disposal of property and equipment | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other assets | 52,000 | 27,000 | 26,000 | 32,000 | 37,000 | 16,000 | 112,000 | 0 | 207,000 | |||||||||||||||||||||||||||||||||||||||||||||||
accrued contract research costs | 2,478,000 | 2,217,000 | 194,000 | 1,289,000 | 499,000 | 2,081,000 | 2,441,000 | 1,010,000 | 140,000 | -57,000 | -231,000 | 1,166,000 | 139,000 | -382,000 | 742,000 | 191,000 | -56,000 | 492,000 | ||||||||||||||||||||||||||||||||||||||
other accrued liabilities | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from the sale of common stock to related parties, net of transaction costs | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
payment of term loans | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payment of capital lease obligations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash (used in) provided by financing activities | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash paid for interest | 827,000 | 96,000 | 213,000 | 267,000 | 325,000 | 443,000 | 495,000 | 560,000 | 596,000 | 533,000 | 789,000 | 428,000 | 406,000 | 501,000 | 717,000 | 376,000 | 371,000 | 32,000 | 40,000 | 48,000 | -10,000 | |||||||||||||||||||||||||||||||||||
maturities of marketable securities | 31,600,000 | 37,000,000 | 15,250,000 | 25,670,000 | 19,768,000 | 18,408,000 | 25,009,000 | 18,950,000 | 16,500,000 | 3,695,000 | 9,650,000 | 14,302,000 | 11,000,000 | 11,342,000 | ||||||||||||||||||||||||||||||||||||||||||
net cash provided by investing activities | 22,381,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash used by financing activities | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock, net of transaction costs, and exercise of common stock options | 7,831,000 | 28,122,000 | 51,555,000 | 10,118,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from the sale of common stock to related parties | 0 | 5,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash (used in) provided by investing activities | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net (decrease) increase in cash and cash equivalents | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from term loans | 0 | 290,000 | 13,210,000 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock, excluding to related parties, and exercise of common stock options, net of transaction costs | 11,000 | 26,000 | 1,045,000 | 28,204,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
collaboration receivable | 0 | 0 | 116,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred collaboration revenue | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from the issuance of common stock, excluding to related parties, net of transaction costs | 158,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from the issuance of common stock to related parties | 25,759,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock and exercise of common stock options, net of transaction costs | 20,000 | 35,018,000 | 190,000 | 39,000 | 69,000 | 26,699,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from term loan | 2,000,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
restricted cash | -389,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
collaboration payable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
supplemental disclosure of noncash operating, investing and financing activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
acquisition of equipment under capital leases | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale—leaseback of property and equipment | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
milestone payments receivable for product development milestones | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
in-process research and development | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
common stock issued for licenses | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
expense deferred offering costs | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other stock-related compensation expense | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
changes in operating assets and liabilities, net of acquisitions: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenue | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash paid for acquisitions, net of cash acquired | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
advances issued to related parties | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repayment of advances from related parties | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuances of common stock and exercise of common stock warrants | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of convertible preferred stock | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from exercise of stock options | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repurchase of common stock from officers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale-leaseback of property and equipment | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payment of capital lease obligation | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payment of deferred offering costs | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
supplemental disclosure of noncash investing and financing activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchase of equipment under capital lease | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible preferred stock beneficial conversion charge | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible preferred stock dividends | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
conversion of preferred stock |