7Baggers
Quarterly
Annual
    Unit: USD2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-09-30 2018-06-30 2018-03-31 2017-09-30 2017-06-30 2017-03-31 2016-09-30 2016-06-30 2016-03-31 2015-09-30 2015-06-30 2015-03-31 2014-09-30 2014-06-30 2014-03-31 2013-09-30 2013-06-30 2013-03-31 2012-09-30 2012-06-30 2012-03-31 2011-09-30 2011-06-30 2011-03-31 2010-06-30 2010-03-31 2009-09-30 2007-09-30 2007-06-30 
      
    		                                                       
      assets
    		                                                       
      current assets:
    		                                                       
      cash and cash equivalents
    		186,193,000 183,646,000 100,019,000 232,684,000 494,597,000 622,517,000 99,915,000 62,055,000 77,196,000 113,308,000 331,549,000 59,340,000 53,272,000 42,282,000 36,269,000 49,174,000 33,540,000 44,205,000 54,004,000 109,120,000 61,867,000 66,651,000 46,697,000 89,486,000 72,508,000 47,493,000 38,046,000 264,861,000 38,125,000 12,960,000 34,797,000 8,215,000 8,393,302 10,756,000 42,815,000 45,537,000 32,003,000 33,255,000 68,478,000 96,811,000 52,034,000 25,477,000 33,783,000 34,962,000 29,442,000 25,593,000 34,550,000 20,643,000 25,891,000 17,372,000 42,611,000 57,917,000 34,803,000  64,526,000 
      restricted cash
    		5,000,000 5,000,000 5,000,000 5,000,000 5,000,000                                                83,000  83,000 
      marketable securities
    		610,831,000 659,422,000 826,232,000 765,943,000 563,197,000 436,546,000 534,216,000 170,296,000 221,222,000 216,169,000 27,225,000 93,852,000 158,494,000 177,671,000 234,077,000 249,970,000 290,306,000 263,019,000 230,145,000 226,817,000 322,513,000 341,859,000 392,348,000 364,124,000 393,888,000 430,332,000 450,492,000 225,444,000 144,700,000 49,177,000 32,369,000 31,912,000 31,164,553 32,259,000 9,227,000 42,715,000 66,331,000 43,351,000 50,802,000 15,249,000 26,753,000 27,907,000 36,420,000 55,432,000 25,697,000 19,063,000 22,840,000 30,017,000 36,998,000 22,861,000 6,047,000  16,942,000   
      trade receivables
    		79,231,000 61,428,000 53,822,000 30,463,000 6,899,000                                                   
      inventory
    		63,497,000 55,241,000 34,068,000 8,715,000 7,072,000 854,000                                                  
      prepaid expenses and other current assets
    		58,604,000 23,242,000 13,786,000 20,861,000 14,963,000 14,035,000 3,150,000 3,118,000 3,177,000 1,807,000 2,595,000 3,920,000 2,780,000 1,217,000 1,338,000 3,812,000 2,221,000 822,000 1,014,000 1,664,000 2,223,000 976,000 1,152,000 1,712,000 2,389,000 565,000 767,000 968,000 374,000 583,000 781,000 225,000 1,632,783 1,820,000 554,000 1,975,000 2,213,000 1,367,000 2,911,000 2,264,000 1,605,000 1,358,000 1,637,000 1,475,000 803,000 839,000 608,000 1,362,000 832,000 524,000 721,000 1,011,000 1,112,000  1,315,000 
      total current assets
    		1,003,356,000 987,979,000 1,032,927,000 1,063,666,000 1,091,728,000 1,073,952,000 637,281,000 235,469,000 301,595,000 331,284,000 361,369,000 157,112,000 214,546,000 221,170,000 271,684,000 302,956,000 326,067,000 308,046,000 285,163,000 337,601,000 386,603,000 409,486,000 440,197,000 455,322,000 468,785,000 478,390,000 489,305,000 491,273,000 183,199,000 62,720,000 67,947,000 40,352,000 41,190,638 44,835,000 52,596,000 90,227,000 100,547,000 77,973,000 122,191,000 114,324,000 80,392,000 54,742,000 71,840,000 91,869,000 55,942,000 45,495,000 57,998,000 52,022,000 63,721,000 40,757,000 49,379,000 58,928,000 52,940,000  65,924,000 
      property and equipment
    		1,615,000 1,901,000 2,190,000 2,268,000 1,695,000 1,742,000 1,553,000 659,000 455,000 512,000 601,000 701,000 789,000 796,000 851,000 844,000 891,000 978,000 1,047,000 1,153,000 1,265,000 1,373,000 1,184,000 181,000 211,000 240,000 244,000 255,000 279,000 111,000 120,000 5,000 1,476 103,000 374,000 561,000 714,000 855,000 1,134,000 1,264,000 1,408,000 1,488,000 1,620,000 1,350,000 1,205,000 1,166,000 1,324,000 1,316,000 1,403,000 1,752,000 3,020,000 3,463,000 4,554,000  5,589,000 
      intangible assets
    		4,548,000 4,639,000 4,729,000 4,819,000 4,910,000 5,000,000                                                  
      right-of-use asset
    		5,862,000 2,110,000 2,401,000 2,512,000 1,456,000 1,586,000 1,713,000 1,836,000 411,000 653,000 602,000 831,000 1,057,000 696,000 797,000 897,000 997,000 707,000 785,000 863,000 520,000 598,000 675,000 751,000 826,000 930,000                              
      total assets
    		1,015,381,000 996,629,000 1,042,247,000 1,073,265,000 1,099,789,000 1,082,280,000 640,547,000 237,964,000 302,461,000 332,449,000 362,572,000 158,644,000 216,392,000 222,662,000 273,332,000 304,697,000 327,955,000 309,731,000 286,995,000 339,617,000 388,388,000 411,457,000 442,056,000 456,254,000 469,822,000 479,560,000 489,549,000 491,528,000 183,478,000 62,831,000 68,067,000 40,357,000 41,507,184 44,938,000 52,970,000 91,014,000 101,539,000 79,392,000 123,656,000 115,946,000 82,184,000 56,663,000 73,924,000 93,700,000 57,613,000 47,164,000 59,841,000 53,868,000 65,621,000 42,926,000 52,550,000 62,542,000 57,562,000  71,600,000 
      liabilities and stockholders’ equity
    		                                                       
      current liabilities:
    		                                                       
      accounts payable
    		37,975,000 42,056,000 43,599,000 45,966,000 8,994,000 21,528,000 28,041,000 16,542,000 17,534,000 12,128,000 23,831,000 18,562,000 11,294,000 22,780,000 21,380,000 10,418,000 1,067,000 4,396,000 1,017,000 6,277,000 5,004,000 1,115,000 1,178,000 773,000 446,000 4,376,000 1,031,000 588,000 1,420,000 1,400,000 1,285,000 2,780,000 1,159,836 680,000 744,000 1,424,000 3,018,000 3,738,000 4,442,000 5,226,000 5,810,000 5,693,000 5,222,000 5,719,000 3,690,000 3,468,000 3,040,000 2,921,000 1,999,000 1,691,000 1,280,000 1,462,000 4,536,000  1,981,000 
      accrued liabilities
    		157,479,000 124,165,000 124,695,000 131,003,000                                                    
      lease liability
    		1,049,000 1,016,000 983,000 878,000 557,000 542,000 527,000 513,000 411,000 653,000 602,000 760,000 879,000 413,000 410,000 406,000 403,000 320,000 318,000 315,000 323,000 319,000 315,000 310,000 306,000 302,000                              
      total current liabilities
    		196,503,000 167,237,000 169,277,000 177,847,000 125,162,000 114,341,000 118,548,000 99,665,000 99,706,000 98,348,000 115,894,000 98,920,000 84,009,000 76,635,000 76,838,000 69,325,000 56,710,000 48,791,000 46,557,000 49,365,000 45,275,000 25,703,000 25,130,000 15,464,000 12,316,000 10,456,000 6,642,000 5,436,000 6,294,000 8,523,000 6,436,000 5,906,000 3,915,390 3,364,000 8,639,000 30,633,000 32,525,000 30,920,000 32,961,000 32,666,000 32,365,000 25,931,000 20,071,000 16,551,000 18,965,000 18,254,000 15,644,000 17,116,000 15,349,000 17,314,000 12,267,000 13,037,000 17,759,000  15,871,000 
      long term liabilities:
    		                                                       
      loan payable, net of discount
    		118,376,000 118,005,000 117,569,000 117,087,000 116,607,000 116,135,000 115,480,000 114,727,000 99,249,000 83,965,000 49,289,000 48,983,000 48,670,000                                           
      total long term liabilities
    		122,900,000 118,755,000 118,587,000 118,263,000 117,507,000 117,180,000 116,666,000 116,050,000 99,249,000 83,965,000 49,289,000 49,054,000 48,848,000 283,000 387,000 491,000 594,000 387,000 468,000 548,000 197,000 279,000 361,000 441,000 520,000 598,000                              
      total liabilities
    		319,403,000 285,992,000 287,864,000 296,110,000 242,669,000 231,521,000 235,214,000 215,715,000 198,955,000 182,313,000 165,183,000 147,974,000 132,857,000 76,918,000 77,225,000 69,816,000 57,304,000 49,178,000 47,025,000 49,913,000 45,472,000 25,982,000 25,491,000 15,905,000 12,836,000 11,054,000 6,642,000 5,436,000 6,294,000 8,523,000 6,436,000 5,906,000 3,915,390 3,364,000 8,639,000 30,644,000 32,557,000 33,252,000 39,928,000 41,948,000 43,960,000 42,051,000 38,488,000 37,096,000 25,423,000 26,700,000 26,071,000 29,287,000 29,184,000 29,825,000 17,031,000 19,153,000 26,726,000  19,139,000 
      stockholders’ equity:
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at june 30, 2025 and december 31, 2024; 2,369,797 and 2,369,797 shares issued and outstanding at june 30, 2025 and december 31, 2024, respectively
    		                                                       
      common stock
    		2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 2,000 1,000 1,000 1,000 1,000 1,157 14,000 14,000 14,000 13,000 11,000 11,000 10,000 9,000 7,000 7,000 7,000 6,000 6,000 6,000 5,000 5,000 4,000 4,000 4,000   3,000 
      additional paid-in-capital
    		2,612,566,000 2,585,666,000 2,556,095,000 2,518,648,000 2,493,288,000 2,334,760,000 1,741,153,000 1,246,385,000 1,228,949,000 1,189,776,000 1,160,079,000 887,660,000 879,538,000 870,972,000 863,495,000 837,636,000 810,295,000 738,575,000 665,385,000 655,622,000 650,211,000 644,413,000 639,567,000 635,535,000 630,550,000 622,678,000 610,845,000 605,418,000 290,182,000 152,276,000 151,247,000 115,692,000 105,161,301 757,626,000 757,081,000 756,053,000 747,055,000 704,403,000 700,927,000 671,240,000 613,180,000 541,849,000 540,155,000 538,538,000 475,273,000 448,555,000 447,226,000 412,262,000 411,375,000 375,545,000 367,480,000 366,276,000 337,376,000   
      accumulated other comprehensive income
    		1,111,000 389,000 468,000 1,271,000 -368,000 -172,000 468,000                       47,000 36,000 64,000  81,000 4,000 11,000  6,000 11,000 3,000 4,000 6,000 9,000 7,000 8,000 4,000 19,000 1,000 10,000 3,000   3,000   
      accumulated deficit
    		-1,917,701,000 -1,875,420,000 -1,802,182,000 -1,742,766,000 -1,635,802,000 -1,483,831,000 -1,336,290,000 -1,224,096,000 -1,125,356,000 -1,039,556,000 -962,660,000 -876,755,000 -795,558,000 -724,828,000 -667,310,000 -602,761,000 -539,661,000 -478,010,000 -425,464,000 -366,341,000 -308,378,000 -259,355,000 -223,220,000 -195,480,000 -174,051,000     -98,016,000                          
      total stockholders’ equity
    		695,978,000 710,637,000 754,383,000 777,155,000 857,120,000 850,759,000 405,333,000 22,249,000 103,506,000 150,136,000 197,389,000 10,670,000 83,535,000 145,744,000 196,107,000 234,881,000 270,651,000 260,553,000 239,970,000 289,704,000 342,916,000 385,475,000 416,565,000 440,349,000 456,986,000 468,506,000 482,907,000 486,092,000 177,184,000 54,308,000 61,631,000 34,451,000 37,591,794 41,574,000 44,331,000 60,370,000 68,982,000 46,140,000 83,728,000 73,998,000 38,224,000 14,612,000 35,436,000 56,604,000 32,190,000 20,464,000 33,770,000 24,581,000 36,437,000 13,101,000 35,519,000 43,389,000 30,836,000  52,461,000 
      total liabilities and stockholders’ equity
    		1,015,381,000 996,629,000 1,042,247,000 1,073,265,000 1,099,789,000 1,082,280,000 640,547,000 237,964,000 302,461,000 332,449,000 362,572,000 158,644,000 216,392,000 222,662,000 273,332,000 304,697,000 327,955,000 309,731,000 286,995,000 339,617,000 388,388,000 411,457,000 442,056,000 456,254,000 469,822,000 479,560,000 489,549,000 491,528,000 183,478,000 62,831,000 68,067,000 40,357,000 41,507,184 44,938,000 52,970,000 91,014,000 101,539,000 79,392,000 123,656,000 115,946,000 82,184,000 56,663,000 73,924,000 93,700,000 57,613,000 47,164,000 59,841,000 53,868,000 65,621,000 42,926,000 52,550,000 62,542,000 57,562,000  71,600,000 
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at march 31, 2025 and december 31, 2024; 2,369,797 and 2,369,797 shares issued and outstanding at march 31, 2025 and december 31, 2024, respectively
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at december 31, 2024 and december 31, 2023; 2,369,797 and 2,369,797 shares issued and outstanding at december 31, 2024 and december 31, 2023, respectively
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at september 30, 2024 and december 31, 2023; 2,369,797 and 2,369,797 shares issued and outstanding at september 30, 2024 and december 31, 2023, respectively
    		                                                       
      accrued expenses
    		    115,611,000 92,271,000 89,980,000 82,610,000 81,761,000 85,567,000 91,461,000 79,598,000 71,836,000 53,442,000 55,048,000 58,501,000 55,240,000 44,075,000 45,222,000 42,773,000 39,948,000 24,269,000 23,637,000 14,381,000 11,564,000 5,778,000 5,611,000 4,848,000 4,874,000 7,123,000 5,151,000 3,126,000 2,755,554                      9,619,000 
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at june 30, 2024 and december 31, 2023; 2,369,797 and 2,369,797 shares issued and outstanding at june 30, 2024 and december 31, 2023, respectively
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at march 31, 2024 and december 31, 2023; 2,369,797 and 2,369,797 shares issued and outstanding at march 31, 2024 and december 31, 2023, respectively
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at december 31, 2023 and december 31, 2022; 2,369,797 and 2,369,797 shares issued and outstanding at december 31, 2023 and december 31, 2022, respectively
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at september 30, 2023 and december 31, 2022; 2,369,797 and 2,369,797 shares issued and outstanding at september 30, 2023 and december 31, 2022, respectively
    		                                                       
      accumulated other comprehensive loss
    		       -42,000 -89,000 -86,000 -32,000 -237,000 -447,000                                           
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at june 30, 2023 and december 31, 2022; 2,369,797 and 2,369,797 shares issued and outstanding at june 30, 2023 and december 31, 2022, respectively
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at march 31, 2023 and december 31, 2022; 2,369,797 and 2,369,797 shares issued and outstanding at march 31, 2023 and december 31, 2022, respectively
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at december 31, 2022 and december 31, 2021; 2,369,797 and 1,969,797 shares issued and outstanding at december 31, 2022 and december 31, 2021, respectively
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at september 30, 2022 and december 31, 2021; 1,969,797 shares issued and outstanding at september 30, 2022 and december 31, 2021
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at june 30, 2022 and december 31, 2021; 1,969,797 shares issued and outstanding at june 30, 2022 and december 31, 2021
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at march 31, 2022 and december 31, 2021; 1,969,797 shares issued and outstanding at march 31, 2022 and december 31, 2021
    		                                                       
      accumulated other comprehensive gain
    		             -402,000 -80,000 4,000 15,000 -14,000 47,000 421,000 1,081,000 415,000 216,000 292,000 485,000 178,000                              
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at december 31, 2021 and december 31, 2020; 1,969,797 shares issued and outstanding at december 31, 2021 and december 31, 2020
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at september 30, 2021 and december 31, 2020; 1,969,797 shares issued andoutstanding at september 30, 2021 and december 31, 2020
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at june 30, 2021 and december 31, 2020; 1,969,797 shares issued and outstanding at june 30, 2021 and december 31, 2020
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at march 31, 2021 and december 31, 2020; 1,969,797 shares issued and outstanding at march 31, 2021 and december 31, 2020
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at december 31, 2020 and december 31, 2019; 1,969,797 shares issued and outstanding at december 31, 2020 and december 31, 2019
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at september 30, 2020 and december 31, 2019; 1,969,797 shares issued and outstanding at september 30, 2020 and december 31, 2019
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at june 30, 2020 and december 31, 2019; 1,969,797 shares issued and outstanding at june 30, 2020 and december 31, 2019
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at march 31, 2020 and december 31, 2019; 1,969,797 shares issued and outstanding at march 31, 2020 and december 31, 2019
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at december 31, 2019 and december 31, 2018; 1,969,797 shares issued and outstanding at december 31, 2019 and december 31, 2018
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at september 30, 2019 and december 31, 2018; 1,969,797 shares issued and outstanding at september 30, 2019 and december 31, 2018
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at june 30, 2019 and december 31, 2018; 1,969,797 shares issued and outstanding at june 30, 2019 and december 31, 2018
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at march 31, 2019 and december 31, 2018; 1,969,797 shares issued and outstanding at march 31, 2019 and december 31, 2018
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at september 30, 2018 and december 31, 2017; 1,969,797 shares issued and outstanding at september 30, 2018 and december 31, 2017
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at june 30, 2018 and december 31, 2017; 1,969,797 shares issued and outstanding at june 30, 2018 and december 31, 2017
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at march 31, 2018 and december 31, 2017; 1,969,797 shares issued and outstanding at march 31, 2018 and december 31, 2017
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at september 30, 2017 and december 31, 2016; 1,969,797 and no shares issued and outstanding at september 30, 2017 and december 31, 2016, respectively
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at june 30, 2017 and december 31, 2016; 1,969,797 and no shares issued and outstanding at june 30, 2017 and december 31, 2016, respectively
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at march 31, 2017 and december 31, 2016; no shares issued and outstanding at each of march 31, 2017 and december 31, 2016
    		                                                       
      other receivable — related party
    		                                                       
      goodwill and other intangibles assets
    		                                315,070                       
      liabilities and stockholders’ deficit
    		                                                       
      convertible promissory notes payable — related parties
    		                                                       
      advances payable — related party
    		                                                       
      accrued interest on advances — related party
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at september 30, 2016 and december 31, 2015; no shares issued and outstanding at each of september 30, 2016 and december 31, 2015
    		                                                       
      accrued contract research costs
    		                                 1,202,000 2,737,000 17,206,000 14,728,000 12,511,000 14,276,000 12,987,000 12,488,000 8,352,000 5,911,000 4,901,000 3,719,000 3,776,000 4,007,000 3,010,000 2,871,000 3,253,000 2,535,000 2,591,000 2,854,000   
      other accrued liabilities
    		                                 1,450,000 2,826,000 5,047,000 5,529,000 5,408,000 4,994,000 5,212,000 4,765,000 4,497,000 3,624,000 2,839,000 3,643,000 3,119,000 2,530,000 3,249,000 2,909,000 2,152,000 2,802,000 3,226,000 4,125,000   
      current portion of capital lease obligations
    		                                 22,000 33,000 43,000 43,000 42,000 42,000 41,000 41,000 4,000 8,000 11,000 13,000           
      current portion of term loans
    		                                 10,000 2,299,000 6,913,000 9,207,000 9,221,000 9,207,000 9,200,000 9,261,000 7,385,000 5,306,000 3,081,000 7,900,000 7,878,000 6,055,000 4,613,000 3,093,000 5,529,000      
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at june 30, 2016 and december 31, 2015; no shares issued and outstanding at each of june 30, 2016 and december 31, 2015
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at march 31, 2016 and december 31, 2015; no shares issued and outstanding at each of march 31, 2016 and december 31, 2015
    		                                                       
      other assets
    		                                   226,000 278,000 564,000 331,000 358,000 384,000 433,000 464,000 481,000 466,000 503,000 519,000 530,000 497,000 417,000 151,000 151,000 68,000  87,000 
      long-term liabilities:
    		                                                       
      capital lease obligations, net of current portion
    		                                   11,000 22,000 33,000 54,000 65,000 75,000    4,000           
      term loans, net of current portion
    		                                    10,000 2,299,000 6,913,000 9,217,000 11,520,000 16,120,000 18,417,000 20,545,000 6,454,000 8,438,000 10,416,000 12,154,000 13,815,000 11,471,000      
      total long-term liabilities
    		                                   11,000 32,000 2,332,000 6,967,000 9,282,000 11,595,000 16,120,000 18,417,000 20,545,000 6,458,000 8,446,000 10,427,000 12,171,000 13,835,000 12,511,000 4,764,000 6,116,000 8,967,000   
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at each of september 30, 2015 and december 31, 2014; no shares issued and outstanding at each of september 30, 2015 and december 31, 2014
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at each of june 30, 2015 and december 31, 2014; no shares issued and outstanding at each of june 30, 2015 and december 31, 2014
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at march 31, 2015 and december 31, 2014; no shares issued and outstanding at each of march 31, 2015 and december 31, 2014
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at september 30, 2014 and december 31, 2013; no shares issued and outstanding at september 30, 2014 and december 31, 2013
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at june 30, 2014 and december 31, 2013; no shares issued and outstanding at june 30, 2014 and december 31, 2013
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at march 31, 2014 and december 31, 2013; no shares issued and outstanding at march 31, 2014 and december 31, 2013
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at september 30, 2013 and december 31, 2012; no shares issued and outstanding at september 30, 2013 and december 31, 2012
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at june 30, 2013 and december 31, 2012; no shares issued and outstanding at june 30, 2013 and december 31, 2012
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at march 31, 2013 and december 31, 2012; no shares issued and outstanding at march 31, 2013 and december 31, 2012
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at september 30, 2012 and december 31, 2011; no shares issued and outstanding at september 30, 2012 and december 31, 2011
    		                                                       
      capital lease obligations
    		                                             13,000 12,000 20,000 31,000 117,000 1,078,000 1,185,000 1,352,000   
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at june 30, 2012 and december 31, 2011; no shares issued and outstanding at june 30, 2012 and december 31, 2011
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at march 31, 2012 and december 31, 2011; no shares issued and outstanding at march 31, 2012 and december 31, 2011
    		                                                       
      collaboration receivable
    		                                                       
      deferred collaboration revenue
    		                                               3,303,000 4,446,000 4,572,000 4,572,000 4,573,000 4,892,000   
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at september 30, 2011 and december 31, 2010; no shares issued and outstanding at september 30, 2011 and december 31, 2010
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at june 30, 2011 and december 31, 2010; no shares issued and outstanding at june 30, 2011 and december 31, 2010
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at march 31, 2011 and december 31, 2010; no shares issued and outstanding at march 31, 2011 and december 31, 2010
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at june 30, 2010 and december 31, 2009; no shares issued and outstanding at june 30, 2010 and december 31, 2009
    		                                                       
      preferred stock, par value 0.0001 per share authorized: 5,000,000 shares at march 31, 2010 and december 31, 2009; no shares issued and outstanding at march 31, 2010 and december 31, 2009
    		                                                       
      deferred collaboration revenue—long-term
    		                                                    7,875,000   
      collaboration payable—long-term
    		                                                       
      capital lease obligations—long-term
    		                                                    1,092,000  3,268,000 
      stockholders’ equity
    		                                                       
      preferred stock, par value 0.0001 per share
    		                                                       
      authorized: 5,000,000 shares at september 30, 2009 and december 31, 2008; no shares issued and outstanding at september 30, 2009 and december 31, 2008
    		                                                       
      authorized: 100,000,000 shares at september 30, 2009 and december 31, 2008; 33,978,300 and 33,919,584 shares issued and outstanding at september 30, 2009 and december 31, 2008, respectively
    		                                                    3,000   
      stockholders' equity
    		                                                       
      marketable securities available-for-sale
    		                                                       
      deferred offering costs
    		                                                       
      capital lease obligations—current
    		                                                      2,440,000 
      other current liabilities
    		                                                      1,831,000 
      deferred revenue
    		                                                       
      convertible preferred stock, at redemption value:
    		                                                       
      series a convertible preferred stock, 0.0001 par value per share. authorized: no shares at june 30, 2007 and 8,000,000 shares at december 31, 2006; no shares issued and outstanding at june 30, 2007 and 8,000,000 shares issued and outstanding at december 31, 2006
    		                                                       
      preferred stock, par value 0.0001 per share. authorized 5,000,000 shares at june 30, 2007 and no shares at december 31, 2006; no shares issued and outstanding at june 30, 2007 and at december 31, 2006
    		                                                       
      additional paid-in capital
    		                                                      322,111,000 
      deficit accumulated during the development stage
    		                                                       
    The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.