7Baggers

Krystal Biotech, Inc
(NASDAQ:KRYS) 

KRYS stock logo

Krystal Biotech, Inc., a clinical stage biotechnology company, engages in the field of redosable gene therapy to treat serious rare diseases in the United States. Its lead product candidate is beremagene geperpavec (B-VEC), which is in Phase III clinical study to treat dystrophic epidermolysis bullo...

Founded: 2015
Full Time Employees: 51
Sector: Healthcare
Industry: Biotechnology
Pharmaceuticals
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At a glance:
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Income Statements:
Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 
                                       
      product revenue
    		116,357,000 107,105,000 97,800,000 96,042,000 88,183,000 91,139,000 83,841,000 70,284,000 45,250,000 42,143,000 8,556,000                         
      yoy
    		31.95% 17.52% 16.65% 36.65% 94.88% 116.26% 879.91%                             
      qoq
    		8.64% 9.51% 1.83% 8.91% -3.24% 8.70% 19.29% 55.32% 7.37% 392.55%                          
      operating expenses
    		                                   
      cost of goods sold
    		6,323,000 6,592,000 4,263,000 7,165,000 5,028,000 4,949,000 6,684,000 6,009,000 2,419,000 2,871,000 223,000                         
      research and development
    		15,331,000 14,794,000 14,585,000 14,410,000 14,255,000 13,523,000 13,511,000 15,583,000 10,957,000 11,370,000 10,629,000 12,144,000 12,288,000 10,741,000 11,516,000 10,890,000 9,314,000 9,009,000 6,080,000 6,594,000 6,201,000 5,672,000 5,100,000 3,639,000 3,525,000 4,349,000 3,885,000 4,216,000 3,167,000 2,802,000 1,914,000 1,525,000 1,520,000 1,088,000 1,355,000 
      selling, general and administrative
    		41,014,000 41,449,000 37,578,000 35,160,000 32,723,000 31,288,000 28,713,000 27,626,000                            
      total operating expenses
    		62,668,000 62,835,000 56,426,000 56,735,000 52,006,000 49,760,000 61,408,000 61,718,000 51,934,000 39,005,000 34,549,000 38,048,000 48,823,000 34,771,000 31,451,000 28,753,000 50,222,000 21,876,000 15,652,000 16,393,000 14,353,000 10,420,000 9,680,000 6,954,000 5,946,000 6,154,000 5,342,000 5,890,000 4,694,000 4,219,000 2,972,000 2,449,000 2,277,000 1,498,000 2,093,000 
      income from operations
    		53,689,000 44,270,000 41,374,000 39,307,000 36,177,000 41,379,000 22,433,000 8,566,000 -6,684,000 3,138,000 -25,993,000 -38,048,000 -48,823,000 -34,771,000 -31,451,000 -28,753,000 -50,222,000 -21,876,000 -15,652,000 -16,393,000 -14,353,000 -10,420,000 -9,680,000 -6,954,000 -5,946,000 -6,154,000 -5,342,000 -5,890,000 -4,694,000 -4,219,000 -2,972,000 -2,449,000 -2,277,000 -1,498,000 -2,093,000 
      yoy
    		48.41% 6.99% 84.43% 358.87% -641.25% 1218.64% -186.30% -122.51% -86.31% -109.02% -17.35% 32.33% -2.79% 58.95% 100.94% 75.40% 249.91% 109.94% 61.69% 135.73% 141.39% 69.32% 81.21% 18.06% 26.67% 45.86% 79.74% 140.51% 106.15% 181.64% 42.00%     
      qoq
    		21.28% 7.00% 5.26% 8.65% -12.57% 84.46% 161.88% -228.16% -313.00% -112.07% -31.68% -22.07% 40.41% 10.56% 9.38% -42.75% 129.58% 39.76% -4.52% 14.21% 37.74% 7.64% 39.20% 16.95% -3.38% 15.20% -9.30% 25.48% 11.26% 41.96% 21.36% 7.55% 52.00% -28.43%  
      operating margin %
    		46.14% 41.33% 42.30% 40.93% 41.02% 45.40% 26.76% 12.19% -14.77% 7.45% -303.80% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      other income
    		                                   
      interest and other income
    		7,753,000 6,861,000 6,593,000 7,468,000 7,420,000 7,231,000 7,336,000 7,479,000 7,616,000 7,519,000 6,740,000 4,838,000 3,526,000 2,719,000 1,601,000 645,000 257,000 70,000 63,000 30,000 33,000 37,000 70,000 121,000 605,000 797,000 1,070,000 542,000 583,000 511,000 217,000 173,000 127,000   
      income before income taxes
    		61,442,000 51,131,000 47,967,000 46,775,000 43,597,000 48,610,000 29,769,000 16,045,000                            
      income tax expense
    		-5,510,000   -8,442,000 -7,864,000 -3,131,000 -2,589,000 -477,000                            
      net income
    		55,932,000 51,400,000 79,365,000 38,333,000 35,733,000 45,479,000 27,180,000 15,568,000 932,000 8,692,000 80,747,000 -33,210,000 -45,297,000 -32,052,000 -29,850,000 -28,108,000 -49,965,000 -21,806,000 -15,589,000 -16,363,000 -15,812,000 -10,383,000 -9,610,000 -6,833,000 -5,341,000 -5,357,000 -4,272,000 -5,348,000 -4,111,000    -2,150,000 -1,393,000 -5,273,000 
      yoy
    		56.53% 13.02% 192.00% 146.23% 3734.01% 423.23% -66.34% -146.88% -102.06% -127.12% -370.51% 18.15% -9.34% 46.99% 91.48% 71.78% 215.99% 110.02% 62.22% 139.47% 196.05% 93.82% 124.95% 27.77% 29.92%    91.21%       
      qoq
    		8.82% -35.24% 107.04% 7.28% -21.43% 67.33% 74.59% 1570.39% -89.28% -89.24% -343.14% -26.68% 41.32% 7.38% 6.20% -43.74% 129.13% 39.88% -4.73% 3.48% 52.29% 8.04% 40.64% 27.93% -0.30% 25.40% -20.12% 30.09%     54.34% -73.58%  
      net income margin %
    		48.07% 47.99% 81.15% 39.91% 40.52% 49.90% 32.42% 22.15% 2.06% 20.63% 943.75% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% -Infinity% -Infinity% -Infinity% 
      unrealized gain on available-for-sale securities
    		-1,577,000 210,750 657,000 -158,000              -5,000 7,000 -24,000 -3,000 -14,000 -20,000 16,000 14,000 -1,000 -7,000 2,000 14,000 1,000 3,000     
      foreign currency translation
    		-1,182,000 237,000 -714,000 925,000                                
      comprehensive income
    		53,173,000 51,436,000 79,308,000 39,100,000 36,313,000 43,777,000 29,326,000 15,233,000 -5,000 9,712,000 80,601,000 -33,292,000 -44,723,000 -31,305,000 -29,780,000 -28,456,000 -50,999,000 -21,955,000 -15,582,000 -16,387,000 -15,815,000 -10,397,000 -9,630,000 -6,817,000 -5,327,000 -5,358,000 -4,279,000 -5,346,000 -4,097,000 -3,707,000 -2,752,000 -2,278,000    
      net income per common share:
    		                                   
      basic
    		1,910 1,770 2,740 1,330 1,240 1,590 950 540 30 320 2,880                         
      diluted
    		1,830 1,700 2,660 1,290 1,200 1,530 910 530 30 310 2,790                         
      weighted-average common shares outstanding:
    		           26,656,883,000 25,712,220,000 25,491,721,000 25,619,125,000 25,545,167,000 25,114,453,000 22,196,846,000 22,212,266,000 22,204,659,000 21,253,508,000 18,787,161,000 19,676,016,000 18,383,941,000 17,359,356,000 15,901,083,000 17,291,245,000 14,522,515 14,417,649       
      basic
    		29,288,000 28,944,000 28,953,000 28,910,000 28,815,000 28,592,000 28,716,000 28,598,000 28,295,000 27,154,190,000 28,042,130,000                         
      diluted
    		30,507,000 29,951,000 29,833,000 29,749,000 29,871,000 29,740,000 29,902,000 29,637,000 29,291,000 27,751,809,000 28,892,226,000                         
      litigation settlement
    		      12,500,000 12,500,000 12,500,000    12,500,000    25,000,000                   
      income tax benefit
    		 269,000 31,398,000                                 
      unrealized gain on available-for-sale securities and other
    		    580,000 218,500 2,146,000 -335,000 -937,000                           
      expenses
    		                                   
      gain from sale of priority review voucher
    		          100,000,000                         
      selling, general, and administrative
    		        26,058,000 18,409,250 23,697,000                         
      expenses:
    		                                   
      other income:
    		                                   
      unrealized gain on available-for-sale securities and currency translation adjustment
    		         86,500 -146,000 -82,000 574,000 -328,000 70,000                     
      general and administrative
    		           25,904,000 24,035,000 24,030,000 19,935,000 17,863,000 15,908,000 12,867,000 9,572,000 9,799,000 8,152,000 4,748,000 4,580,000 3,315,000 2,421,000 1,805,000 1,457,000 1,674,000 1,527,000 1,417,000 1,058,000 924,000 757,000 410,000 738,000 
      net loss per common share: basic and diluted
    		           -1,250 -1,760 -1,250 -1,170 -1,100 -1,990 -950 -700  -740 -530 -490 -370 -310 -310 -250         
      weighted-average common shares outstanding:
    		           26,656,883,000 25,712,220,000 25,491,721,000 25,619,125,000 25,545,167,000 25,114,453,000 22,196,846,000 22,212,266,000 22,204,659,000 21,253,508,000 18,787,161,000 19,676,016,000 18,383,941,000 17,359,356,000 15,901,083,000 17,291,245,000 14,522,515 14,417,649       
      interest expense
    		                    -1,492,000             -813,250 -3,180,000 
      unrealized loss on available-for-sale securities and currency translation adjustment
    		               -348,000                    
      unrealized loss on available-for-sale securities and other
    		                -1,034,000                   
      net income per common share: basic and diluted
    		                   -740                
      other expense
    		                                   
      total interest and other income
    		                           542,000 583,000 511,000 217,000 173,000 127,000   
      net loss attributable to common stockholders per share: basic and diluted
    		                           -0.37 -0.29       
      net loss applicable to stockholders and members
    		                             -1,795,250 -2,755,000 -2,276,000 -2,150,000 -1,393,000 -5,273,000 
      net loss attributable to common stockholders and members per share: basic and diluted
    		                             -0.173 -0.26 -0.22 -0.21   
      weighted-average common shares and common units outstanding: basic and diluted
    		                             11,203,081 10,624,113 10,310,101 10,307,379 5,360,536  
      unrealized loss on available-for-sale securities
    		                               -2,000    
      total other expense
    		                                 105,000 -3,180,000 
      net loss attributable to common stockholders per share:
    		                                   
      basic and diluted
    		                                 -0.438 -1.26 
      weighted-average common shares and common units outstanding
    		                                   
      basic and diluted
    		                                  4,183,075 
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 
                                        
        assets
      		                                  
        current assets
      		                                  
        cash and cash equivalents
      		501,313,000 496,304,000 392,604,000 353,829,000 308,770,000 344,865,000 373,966,000 345,786,000 359,006,000 358,328,000 373,241,000 275,875,000 140,745,000 161,900,000 186,409,000 218,720,000 269,303,000 341,246,000 286,614,000 329,527,000 402,172,000 268,269,000 282,369,000 291,678,000 180,225,000 187,514,000 194,806,000 186,587,000 98,013,000 103,670,000 46,667,000 41,813,000 47,228,000  
        short-term investments
      		322,092,000 331,487,000 338,465,000 328,157,000 308,076,000 252,652,000 214,358,000 213,826,000 179,253,000 173,850,000 188,828,000 201,642,000 209,642,000 217,271,000 208,011,000 206,845,000 165,329,000 96,850,000 56,479,000 38,203,000 1,248,000 2,993,000 3,996,000 5,496,000 6,479,000 6,171,000 8,402,000 8,879,000 8,617,000 8,091,000 5,627,000 3,637,000   
        accounts receivable
      		127,022,000 127,425,000 129,633,000 111,439,000 103,260,000 104,746,000 97,298,000 103,236,000 46,467,000 42,040,000 9,316,000                        
        inventory
      		42,646,000 40,475,000 37,632,000 31,041,000 29,942,000 26,508,000 18,581,000 12,179,000 11,037,000 6,985,000 5,278,000                        
        prepaid taxes
      		10,642,000 14,006,000 10,103,000                                
        prepaid expenses and other current assets
      		16,026,000 14,905,000 17,213,000 16,881,000 16,750,000 13,274,000 8,961,000 7,745,000 6,485,000 6,706,000 5,465,000 6,487,000 5,042,000 4,608,000 3,158,000 3,205,000 3,366,000 4,171,000 2,719,000 2,197,000 2,406,000  1,287,000 1,365,000 1,625,000          
        total current assets
      		1,019,741,000 1,024,602,000 925,650,000 841,347,000 766,798,000 742,045,000 713,164,000 682,772,000 602,248,000 587,909,000 582,128,000 484,004,000 355,429,000 383,779,000 397,578,000 428,770,000 437,998,000 442,267,000 345,812,000 369,927,000 405,826,000 275,058,000 287,652,000 298,539,000 188,329,000 195,880,000 204,435,000 196,203,000 107,894,000 112,650,000 52,821,000 45,710,000 47,669,000 49,914,000 
        property and equipment
      		153,582,000 150,776,000 148,871,000 150,388,000 151,070,000 155,168,000 156,592,000 158,808,000 160,011,000 161,202,000 164,029,000 163,737,000 163,073,000 161,684,000 157,786,000 151,214,000 136,927,000 112,355,000 78,642,000 44,972,000 33,883,000 30,876,000 17,512,000 13,215,000 10,264,000 8,475,000 6,863,000 5,961,000 4,354,000 3,014,000 1,632,000 256,000 182,000 200,000 
        long-term investments
      		193,485,000 128,066,000 133,113,000 138,807,000 148,472,000 152,114,000 105,888,000 69,292,000 83,996,000 61,954,000 36,548,000 28,410,000 5,129,000 4,621,000 12,557,000 12,902,000 33,339,000 64,371,000 19,237,000 21,411,000      497,000         
        right-of-use assets
      		7,035,000 7,239,000 7,447,000 7,655,000 7,858,000 6,280,000 6,471,000 6,660,000 6,845,000 7,027,000 7,360,000 7,590,000 7,814,000 8,042,000 8,253,000 8,279,000 8,453,000 7,228,000 7,342,000 7,136,000 3,200,000 3,298,000             
        deferred tax asset, net of valuation allowance
      		22,824,000 22,824,000 24,680,000                                
        other non-current assets
      		300,000 287,000 333,000 197,000 218,000 231,000 203,000 126,000 196,000 263,000 285,000 285,000 402,000 324,000 205,000 159,000 157,000 74,000 62,000 110,000 109,000 1,612,000 1,411,000 1,436,000 1,505,000          
        total assets
      		1,396,967,000 1,333,794,000 1,240,094,000 1,138,394,000 1,074,416,000 1,055,838,000 982,318,000 917,658,000 853,296,000 818,355,000 790,350,000 684,026,000 531,847,000 558,450,000 576,379,000 601,324,000 616,874,000 626,295,000 451,095,000 443,556,000 443,018,000 310,844,000 311,451,000 318,145,000 205,131,000 209,023,000 214,232,000 205,156,000 115,704,000 116,116,000 54,453,000 46,030,000 47,851,000 50,114,000 
        liabilities and stockholders’ equity
      		                                  
        current liabilities
      		                                  
        accounts payable
      		4,089,000 3,238,000 2,097,000 7,124,000 2,672,000 4,985,000 5,580,000 5,425,000 5,359,000 4,132,000 4,340,000 4,446,000 4,109,000 3,981,000 5,761,000 9,229,000 8,209,000 8,398,000 4,757,000 1,265,000 1,844,000 2,105,000 2,591,000 1,613,000 636,000 724,000 1,252,000 896,000 1,126,000 888,000 378,000 214,000 89,000 193,000 
        current portion of lease liability
      		1,800,000 1,771,000 1,698,000 1,617,000 1,362,000 1,217,000 1,292,000 1,361,000 1,430,000 1,474,000 1,501,000 1,529,000 1,553,000 1,561,000 1,547,000 1,417,000 1,411,000 1,041,000 1,023,000 934,000 648,000 638,000 564,000 539,000 509,000  462,000 438,000 418,000      
        accrued rebates
      		70,717,000 58,181,000 55,769,000 51,638,000 47,405,000 36,804,000 29,545,000 21,733,000 11,289,000                          
        accrued expenses and other current liabilities
      		31,196,000 39,752,000 31,704,000 26,517,000 28,050,000 58,989,000 53,110,000 43,332,000 29,511,000 27,488,000 21,742,000 17,923,000 29,414,000 23,305,000 20,724,000 23,781,000 50,817,000 16,297,000 29,999,000 15,920,000 6,652,000 5,109,000 4,043,000 3,679,000 2,916,000 2,123,000 2,012,000 2,606,000 1,698,000 1,708,000 1,538,000 545,000 363,000 447,000 
        total current liabilities
      		107,802,000 102,942,000 91,268,000 86,896,000 79,489,000 101,995,000 89,527,000 71,851,000 47,589,000 33,094,000 27,583,000 23,898,000 35,076,000 28,847,000 28,032,000 34,427,000 60,437,000 25,736,000 35,779,000 18,119,000 9,144,000 15,452,000 7,198,000 5,831,000 4,061,000 3,327,000 3,726,000 3,940,000 3,242,000 2,596,000 1,916,000 759,000 452,000 640,000 
        lease liability
      		7,312,000 7,568,000 7,813,000 8,064,000 8,300,000 6,044,000 6,184,000 6,326,000 6,465,000 6,620,000 6,819,000 7,014,000 7,205,000 7,372,000 7,575,000 7,716,000 7,883,000 6,983,000 7,079,000 6,897,000 3,222,000 3,308,000 2,533,000 2,618,000 2,701,000  2,860,000 2,926,000 2,976,000      
        other long-term liabilities
      		5,124,000 3,724,000 3,137,000 2,787,000 1,953,000 1,419,000 761,000 588,000                           
        total liabilities
      		120,238,000 114,234,000 102,218,000 97,747,000 89,742,000 109,458,000 96,472,000 78,765,000 54,054,000 39,714,000 34,402,000 30,912,000 42,281,000 36,219,000 35,607,000 42,143,000 68,320,000 32,719,000 42,858,000 25,016,000 12,366,000 18,760,000 9,731,000 8,449,000 6,762,000 6,109,000 6,586,000 6,866,000 6,218,000 2,890,000 2,161,000 759,000 452,000 640,000 
        commitments and contingencies
      		                                  
        stockholders’ equity
      		                                  
        common stock; 0.00001 par value...
      		                                  
        additional paid-in capital
      		1,198,257,000 1,194,261,000 1,164,013,000 1,146,092,000 1,129,219,000 1,127,238,000 1,110,481,000 1,092,854,000 1,068,436,000 1,047,830,000 1,034,849,000 1,012,616,000 815,776,000 803,718,000 790,954,000 779,583,000 740,500,000 734,523,000 527,229,000 521,950,000 517,675,000 363,292,000 362,531,000 360,877,000 242,733,000 241,951,000 241,325,000 227,690,000 133,540,000 133,183,000 68,542,000 58,769,000 58,619,000 58,544,000 
        accumulated other comprehensive gain
      		-1,623,000  1,100,000 1,157,000 390,000 -190,000 1,512,000 -634,000 -299,000 638,000                    2,000     
        retained earnings
      		80,095,000 24,163,000                                 
        total stockholders’ equity
      		1,276,729,000 1,219,560,000 1,137,876,000 1,040,647,000 984,674,000 946,380,000 885,846,000 838,893,000 799,242,000                          
        total liabilities and stockholders’ equity
      		1,396,967,000 1,333,794,000 1,240,094,000 1,138,394,000 1,074,416,000 1,055,838,000 982,318,000 917,658,000 853,296,000                          
        stockholders' equity
      		                                  
        accumulated other comprehensive income
      		 1,136,000                -163,000 -14,000 -21,000 3,000 6,000 20,000 40,000 24,000 10,000 11,000 18,000 16,000      
        accumulated deficit
      		  -27,237,000 -106,602,000 -144,935,000 -180,668,000 -226,147,000 -253,327,000 -268,895,000 -269,827,000 -278,519,000 -359,266,000 -326,056,000 -280,759,000 -248,707,000 -218,857,000 -190,749,000 -140,784,000 -118,978,000 -103,389,000 -87,026,000 -71,214,000 -60,831,000 -51,221,000 -44,388,000 -39,047,000 -33,690,000 -29,418,000 -24,070,000 -19,959,000 -16,251,000 -13,496,000 -11,220,000 -9,070,000 
        liabilities and stockholders' equity
      		                                  
        total stockholders' equity
      		         778,641,000 755,948,000 653,114,000 489,566,000 522,231,000 540,772,000 559,181,000 548,554,000 593,576,000 408,237,000 418,540,000 430,652,000 292,084,000 301,720,000 309,696,000 198,369,000 202,914,000 207,646,000 198,290,000 109,486,000 113,226,000 52,292,000 45,271,000 47,399,000  
        total liabilities and stockholders' equity
      		         818,355,000 790,350,000 684,026,000 531,847,000 558,450,000 576,379,000 601,324,000 616,874,000 626,295,000 451,095,000 443,556,000 443,018,000 310,844,000 311,451,000 318,145,000 205,131,000 209,023,000 214,232,000 205,156,000 115,704,000      
        accumulated other comprehensive loss
      		          -382,000 -236,000 -154,000 -728,000 -1,475,000 -1,545,000               1,000 -2,000   
        preferred stock; 0.00001 par value...
      		                                  
        accumulated other comprehensive expense
      		                -1,197,000                  
        build-to-suit lease liability
      		                     7,600,000             
        build to suit lease liability
      		                                  
        prepaid and other current assets
      		                     3,796,000    2,195,000 1,227,000 737,000 1,264,000 889,000 527,000 260,000 441,000  
        prepaid rent
      		                      2,400,000 2,400,000 2,400,000          
        right-of-use asset
      		                      2,476,000 2,555,000 2,633,000 2,709,000 2,796,000 2,906,000 3,001,000      
        other noncurrent assets
      		                         1,462,000 138,000 86,000 455,000 452,000  64,000   
        current portion of lease liabilities
      		                         480,000         
        lease liabilities
      		                         2,782,000         
        other noncurrent liabilities
      		                             294,000 245,000    
        liabilities, convertible preferred stock, stockholders' and members’ equity
      		                                  
        preferred stock
      		                                  
        total preferred stock
      		                                  
        total liabilities, preferred stock and stockholders' equity
      		                             116,116,000 54,453,000 46,030,000 47,851,000  
        liabilities, preferred stock and stockholders' equity
      		                                  
        cash
      		                                 49,591,000 
        prepaid assets
      		                                 304,000 
        other current assets
      		                                 19,000 
        liabilities, convertible preferred stock and stockholders' and members’ equity
      		                                  
        accrued interest
      		                                  
        related party convertible promissory notes
      		                                  
        convertible promissory notes
      		                                  
        stockholders' and members’ equity
      		                                  
        common units; no par value; no common units authorized, issued, or outstanding at december 31, 2017; 3,490,884 units authorized, issued, and outstanding at december 31, 2016
      		                                  
        preferred units; no par value; no preferred units authorized, issued, or outstanding at december 31, 2017; 179,613 units authorized, issued, and outstanding at december 31, 2016
      		                                  
        total stockholders' and members’ equity
      		                                 49,474,000 
        total liabilities, convertible preferred stock and stockholders' and members’ equity
      		                                 50,114,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 
                                          
          operating activities
        		                                  
          net income
        		55,932,000 51,400,000 79,364,000 38,334,000 35,733,000 45,479,000 27,179,000 15,569,000 932,000 8,692,000                         
          adjustments to reconcile net income to net cash from operating activities
        		                                  
          depreciation
        		1,522,000 1,562,000 1,403,000 1,349,000 1,410,000 1,364,000 1,341,000 1,835,000 1,427,000                335,000 250,000 191,000 175,000 132,000 61,000 38,000 24,000 18,000 14,000 
          accretion on marketable securities
        		-576,000    -453,000  -431,000 -302,000 -802,000                          
          amortization of operating lease right-of-use assets
        		204,000 200,000 209,000 194,000 224,000 191,000 188,000 186,000 182,000                          
          stock-based compensation expense
        		13,609,000 13,764,000 13,153,000 14,119,000 13,478,000 13,356,000 13,316,000 13,156,000 9,299,000 9,853,000 8,312,000 11,331,000 10,437,000 9,552,000 9,059,000 8,189,000 6,430,000 5,145,000 3,666,000 4,195,000 2,313,000 570,000 1,356,000 807,000 539,000 323,000 278,000 325,000 313,000 302,000 278,000 147,000 65,000 58,000 
          realized gain on investments
        		-529,000 -404,000 -1,293,000 -2,754,000 -1,502,000 -1,642,000 -1,568,000 -1,646,000 -1,213,000                          
          other
        		136,000 289,000 -295,000 76,000 614,000 -73,000 636,000 327,000 -238,000 3,839,000 -1,919,000 -1,766,000 -605,000 -538,000 -58,000 -31,000 -135,000                  
          changes in operating assets and liabilities
        		                                  
          accounts receivable
        		58,000 2,492,000 -17,923,000 -8,179,000 1,486,000 -7,449,000 5,939,000 -56,769,000 -4,427,000 -32,724,000                         
          inventory
        		-243,000 -1,058,000 -4,713,000 880,000 -1,395,000 -6,521,000 -3,678,000 530,000 -2,238,000 -492,000                         
          prepaid taxes
        		3,365,000 -2,286,000                                 
          prepaid expenses and other current assets
        		-1,699,000  -1,354,000 19,000 -2,976,000  -104,000 -2,268,000 -264,000 -771,000 1,387,000 -1,197,000 -327,000 -1,342,000 183,000 28,000 820,000 -1,959,000 -552,000 54,000 1,312,000 -2,400,000 123,000 258,000 108,000          
          lease liability
        		-227,000 -165,000 -155,000 -122,000 -136,000 -216,000 -211,000 -207,000 -199,000 -226,000 -223,000 -215,000 -165,000 -188,000 -173,000 -160,000 -126,000 -45,000 -65,000 -98,000 -77,000 850,000 -60,000            
          other long-term liabilities
        		1,435,000 562,000 350,000 834,000 534,000 658,000 173,000                            
          accounts payable
        		1,022,000 -183,000 -4,020,000 4,123,000 906,000 -591,000 91,000 784,000 727,000 -222,000 -360,000 374,000 107,000 -938,000 -340,000 578,000 -554,000 937,000 455,000 -974,000 294,000 58,000 19,000 462,000 244,000 -369,000 -243,000 -170,000 583,000 -17,000 108,000 125,000 -104,000 -138,000 
          accrued rebates
        		12,685,000 2,310,000 4,124,000 4,233,000 10,601,000 7,259,000 7,812,000 10,444,000 5,312,000                          
          accrued expenses and other current liabilities
        		-6,312,000 5,786,000 5,917,000 -1,294,000 3,695,000 7,483,000 1,942,000 1,128,000 -5,162,000 2,763,000 3,461,000 1,799,000 -3,465,000 2,157,000 540,000 463,000 2,013,000 -4,021,000 4,048,000 2,390,000 288,000 1,325,000 899,000 -181,000 262,000 -144,000 263,000 275,000 153,000 163,000 380,000 181,000 -80,000 -393,000 
          accrued legal settlement
        		                25,000,000                  
          net cash from operating activities
        		80,382,000 77,508,000 39,659,000 52,729,000 30,969,000 52,843,000 58,857,000 -4,168,000 15,888,000 -7,232,000 -21,226,000 -34,190,000 -26,156,000 -22,329,000 -19,688,000 -43,059,000 -15,493,000 -20,900,000 -7,255,000 -10,129,000 -9,654,000 -8,024,000 -6,766,000 -5,066,000 -6,227,000  -4,243,000 -4,209,000 -3,215,000 -3,518,000 -1,940,000 -1,618,000 -2,369,000 -2,127,000 
          capital expenditures
        		-5,930,000 -2,139,000 -2,410,000 -1,972,000 -4,807,000 -801,000 -1,322,000 -1,019,000 7,196,000 -1,847,000 -1,676,000 -3,657,000 6,484,000 -5,217,000 -20,985,000 -16,515,000 -2,684,000 -48,733,000 -7,921,000 3,539,000 142,000 -683,000 -3,684,000 -573,000 -206,000  -462,000 -1,238,000 -1,332,000 -1,304,000 -832,000 0  -159,000 
          free cash flows
        		74,452,000 75,369,000 37,249,000 50,757,000 26,162,000 52,042,000 57,535,000 -5,187,000 23,084,000 -9,079,000 -22,902,000 -37,847,000 -19,672,000 -27,546,000 -40,673,000 -59,574,000 -18,177,000 -69,633,000 -15,176,000 -6,590,000 -9,512,000 -8,707,000 -10,450,000 -5,639,000 -6,433,000  -4,705,000 -5,447,000 -4,547,000 -4,822,000 -2,772,000 -1,618,000  -2,286,000 
          investing activities
        		                                  
          proceeds from disposal of assets
        		 0 0 0 435,000                              
          purchases of property and equipment
        		-7,148,000 -2,139,000 -1,704,000 -1,904,000 -6,204,000 -801,000 -1,046,000 -1,131,000 -1,260,000 -1,847,000 -1,781,000 -2,790,000 -5,381,000 -5,217,000 -14,056,000 -16,515,000 -17,191,000 -40,883,000 -20,991,000 -3,989,000 -2,473,000 -7,207,000 -4,182,000 -1,946,000 -1,508,000 -2,279,000 -1,175,000 -1,238,000 -1,707,000 -1,304,000 -832,000   -159,000 
          purchases of investments
        		-160,033,000   -113,899,000 -137,806,000 -143,472,000 -112,532,000 -113,401,000 -88,335,000 -82,906,000 -105,901,000 -174,393,000 -145,576,000 -104,069,000 -67,457,000 -84,501,000 -62,754,000 -106,652,000                 
          maturities of investments
        		103,598,000   105,278,000 88,806,000 60,495,000 79,250,000 95,179,000 63,615,000                          
          net cash from investing activities
        		-63,583,000 11,163,000 -4,286,000 -10,525,000 -54,769,000 -83,778,000 -34,328,000 -19,353,000 -25,980,000 -10,160,000 105,192,000 -15,957,000 3,563,000 -5,208,000 -14,743,000 -38,224,000 -55,908,000 -126,540,000 -37,166,000 -62,317,000 -747,000 -6,217,000 -2,709,000 -950,000 -1,305,000  -705,000 -1,236,000 -2,482,000 -3,767,000 -2,755,000   -159,000 
          financing activities
        		                                  
          proceeds from exercise of stock options
        		6,501,000 15,689,000 3,714,000 1,796,000 1,462,000 2,428,000 3,365,000 10,638,000 15,969,000                          
          taxes paid for employee tax withholding related to restricted stock units
        		-16,960,000 -23,000 -5,000 0 -12,116,000 0 0 0 -4,181,000                          
          taxes paid related to settlement of restricted stock awards
        		 0 0 0 -1,812,000 0 0 0 -1,205,000 0 0 0 -749,000 0 0 0 -649,000                  
          net cash from financing activities
        		-10,459,000 15,666,000 3,709,000 1,796,000 -12,466,000 2,428,000 3,365,000 10,638,000 10,583,000 2,619,000 13,388,000 185,269,000 1,474,000 3,069,000 2,120,000 30,700,000 -542,000 202,072,000 1,508,000 -199,000 144,304,000 141,000 166,000 117,469,000 243,000  13,167,000 94,019,000 40,000 64,288,000 9,549,000 4,000 6,000 -693,000 
          effect of exchange rate changes on cash and cash equivalents
        		-1,331,000 -637,000 -307,000 1,059,000 171,000 -594,000 286,000 -337,000 187,000 -140,000 12,000 8,000 -36,000                      
          net increase in cash and cash equivalents
        		5,009,000  38,775,000 45,059,000 -36,095,000  28,180,000 -13,220,000 678,000  97,366,000    -32,311,000 -50,583,000 -71,943,000 54,632,000 -42,913,000 -72,645,000 133,903,000 -14,100,000 -9,309,000   -7,292,000 8,219,000   57,003,000 4,854,000    
          cash and cash equivalents at beginning of period
        		496,304,000  0 0 344,865,000  0 0 358,328,000  0 0 161,900,000  0 0 341,246,000  0 0 268,269,000  0 0 187,514,000  0 0 103,670,000 0 0 0 49,591,000  
          cash and cash equivalents at end of period
        		501,313,000  38,775,000 45,059,000 308,770,000  28,180,000 -13,220,000 359,006,000  97,366,000 135,130,000 140,745,000  -32,311,000 -50,583,000 269,303,000  -42,913,000 -72,645,000 402,172,000  -9,309,000 111,453,000 180,225,000  8,219,000 88,574,000 98,013,000 57,003,000 4,854,000 -5,415,000 47,228,000  
          supplemental disclosures of non-cash activities
        		                                  
          unpaid purchases of property and equipment
        		1,218,000                14,507,000 -7,850,000 13,070,000 7,528,000 2,615,000 6,524,000 498,000 1,373,000 1,302,000 -345,000 713,000        
          initial recognition of right-of-use assets
        		 -8,000 0 -8,000 1,802,000         0 162,000 0 1,394,000            3,394,000      
          supplemental cash flow information
        		                                  
          income taxes paid
        		627,000 1,797,000 18,000 13,458,000 400,000 515,000 3,148,000                            
          gain from sale of priority review voucher
        		         0                         
          deferred tax asset
        		                                  
          accretion of marketable securities
        		                                  
          prepaid expenses and other assets
        		                                  
          proceeds from sale of priority review voucher
        		         0                         
          proceeds from issuance of common stock
        		                                  
          net change in cash and cash equivalents
        		                                  
          cash and cash equivalents at beginning of year
        		                                  
          cash and cash equivalents at end of year
        		                                  
          supplemental disclosures of non-cash investing and financing activities
        		                                  
          supplemental disclosure of cash flow information
        		                                  
          deferred income taxes
        		                                  
          amortization on marketable securities
        		  -325,000                                
          accrued litigation settlement
        		  0 0 -31,250,000  6,250,000 12,500,000 12,500,000    12,500,000                      
          purchases of available-for-sale securities
        		                                  
          maturities of available-for-sale securities
        		                                  
          unpaid purchases of property and equipment included in accounts payable and accrued expenses
        		  -706,000 -68,000 1,397,000  -276,000 112,000 8,456,000  105,000 -867,000 11,865,000  -6,929,000                    
          amortization of marketable securities
        		                                  
          other non-current assets
        		      -18,000 -23,000 52,000 -16,000 -158,000 156,000 -46,000 -119,000 -46,000 6,000 9,000                  
          proceeds from issuance of common stock, net of offering costs
        		                                  
          supplemental disclosures of non-cash investing activities
        		                                  
          amortization
        		                                  
          loss on disposal of fixed assets
        		                                  
          non-cash interest expense
        		                 0 0 0 1,492,000             0 
          issuance of common stock, net of issuance costs
        		         2,619,000                         
          repayment of astra build-to-suit liability
        		                                  
          depreciation and amortization
        		          826,000 1,038,000 705,000 1,089,000 975,000 976,000 1,015,000 784,000 783,000 666,000 536,000 490,000 477,000            
          loss on disposals of fixed assets
        		                      30,000   13,000 0        
          proceeds from maturities of investments
        		          112,874,000 161,226,000 154,520,000 104,078,000 66,770,000 62,792,000 24,037,000 20,995,000                 
          net loss
        		           -33,210,000 -45,297,000 -32,052,000 -29,850,000 -28,108,000 -49,965,000 -21,806,000   -15,812,000 -10,383,000 -9,610,000 -6,833,000 -5,341,000 -5,357,000 -4,272,000 -5,348,000 -4,111,000 -3,708,000 -2,755,000 -2,276,000 -2,150,000 -1,393,000 
          adjustments to reconcile net loss to net cash from operating activities
        		                                  
          issuance of common stock
        		           185,269,000 2,223,000  2,120,000 30,700,000 107,000  1,508,000 -199,000 152,264,000 141,000 166,000 117,469,000 243,000 299,000 13,167,000 94,019,000 40,000 64,288,000 9,549,000    
          net (decrease) in cash and cash equivalents
        		            -21,155,000                      
          repayment of astra build to suit liability
        		                 0 0 0 -7,960,000              
          unpaid offering costs
        		                24,000  -25,000 -178,000 214,000   110,000 22,000          
          prepaid rent
        		                      0 0 -2,400,000          
          initial recognition of right-of-use assets and modification
        		                  336,000                
          purchases of short-term investments
        		                     0 -12,000 -1,226,000 -1,967,000 -1,706,000 -2,218,000 -4,137,000 -512,000 -2,463,000 -1,987,000    
          proceeds from maturities of short-term investments
        		                   1,233,000 1,726,000 990,000 1,485,000 2,222,000 2,170,000 3,937,000 2,688,000        
          purchases of long-term investments
        		                                  
          decrease in
        		                                  
          amortization of right-of-use asset
        		                        26,000 26,000 68,000 65,000 67,000      
          purchase of other noncurrent assets
        		                                  
          net decrease in cash and cash equivalents
        		                        -7,289,000    -5,657,000      
          adjustments to reconcile net loss to net cash and cash equivalents from operating activities
        		                                  
          increase in
        		                                  
          prepaids and other current assets
        		                         -426,000 -528,000 415,000 -352,000 -367,000 -17,000    
          other noncurrent liabilities
        		                             48,000     
          net cash and cash equivalents from operating activities
        		                                  
          net cash and cash equivalents from investing activities
        		                                  
          net cash and cash equivalents from financing activities
        		                                  
          deferred rent liabilities
        		                                  
          purchases of other noncurrent assets
        		                            -263,000      
          issuance of preferred stock and preferred units
        		                                 0 
          unpaid purchase of property and equipment
        		                            375,000      
          unpaid deferred offering costs
        		                            155,000    1,000 -1,304,000 
          proceeds from the issuance of convertible promissory notes
        		                                 -1,000,000 
          proceeds from the issuance of related party convertible promissory notes
        		                                  
          conversion of convertible promissory notes to preferred stock
        		                                 0 
          conversion of preferred stock to common stock
        		                                 0 
          unpaid construction-in-progress
        		                                  
          conversion of preferred units to preferred stock
        		                                  
          prepaids and other assets
        		                                -118,000  
          issuance of common stock and common units
        		                                6,000 -693,000 
          net increase in cash
        		                                -2,363,000 -2,979,000 
          prepaid and other assets
        		                                  
          cash at beginning of period
        		                                 0 
          cash at end of period
        		                                 -2,979,000 
          conversion of common units to preferred units
        		                                  
          prepaid research and development expenses