7Baggers

Kiniksa Pharmaceuticals, Ltd
(NASDAQ:KNSA) 

KNSA stock logo

Kiniksa Pharmaceuticals, Ltd., a clinical-stage biopharmaceutical company, focuses on discovering, acquiring, developing, and commercializing therapeutic medicines for patients suffering from debilitating diseases with significant unmet medical need worldwide. Its product candidates include Rilonace...

Founded: 2015
Full Time Employees: 135
Sector: Healthcare
Industry: Biotechnology
Pharmaceuticals
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At a glance:
Bull Thesis:
Bear Thesis:
Main Competitors:
Moat:
Income Statements:
Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 
                                    
      revenue:
    		                                
      product revenue
    		214,266,000 202,127,000 180,855,000 156,797,000 137,785,000 122,536,000 112,214,000 103,394,000 78,885,000 71,220,000 64,802,000 54,495,000 42,659,000 39,939,000 33,424,000 26,972,000 22,189,000 18,745,000 12,095,000 7,704,000             
      license and collaboration revenue
    		       5,237,000 973,000 12,175,000 2,244,000 16,978,000 5,686,000 21,945,000 65,711,000                  
      total revenue
    		214,266,000 202,127,000 180,855,000 156,797,000 137,785,000 122,536,000 112,214,000 108,631,000 79,858,000 83,395,000 67,046,000 71,473,000 48,345,000 61,884,000 99,135,000 26,972,000 32,189,000                
      yoy
    		55.51% 64.95% 61.17% 44.34% 72.54% 46.93% 67.37% 51.99% 65.18% 34.76% -32.37% 164.99% 50.19%                    
      qoq
    		6.01% 11.76% 15.34% 13.80% 12.44% 9.20% 3.30% 36.03% -4.24% 24.38% -6.19% 47.84% -21.88% -37.58% 267.55% -16.21%                 
      costs and operating expenses:
    		                                
      cost of goods sold
    		20,796,000 20,945,000 20,257,000 18,603,000 17,868,000 17,896,000 20,109,000 12,322,000 10,583,000 9,584,000 9,088,000 7,699,000 7,036,000 6,710,000 6,937,000 5,029,000 4,219,000 3,867,000 2,767,000 2,466,000             
      collaboration expenses
    		75,577,000 70,030,000 63,307,000 52,418,000 43,790,000 48,189,000 29,307,000 30,014,000 20,801,000 16,939,000 17,311,000 13,986,000 8,288,000 7,522,000 4,623,000 3,672,000 8,254,000                
      research and development
    		27,475,000 34,609,000 24,166,000 18,753,000 19,325,000 35,215,000 26,057,000 24,017,000 26,334,000 20,052,000 17,106,000 23,767,000 15,172,000 14,390,000 16,485,000 13,798,000 20,817,000 27,433,000 19,236,000 23,945,000 28,683,000 37,398,000 31,419,000 22,324,000 20,901,000 22,886,000 22,014,000 30,848,000 59,253,000 36,122,000 20,644,000 17,200,000 
      selling, general and administrative
    		61,151,000 56,775,000 49,104,000 46,863,000 43,530,000 40,535,000 46,399,000 42,395,000 38,682,000 36,739,000 34,468,000 29,175,000 29,045,000 27,215,000 24,677,000 23,841,000 22,218,000 22,741,000 20,759,000 21,848,000 20,600,000            
      total operating expenses
    		184,999,000 182,359,000 156,834,000 136,637,000 124,513,000 141,835,000 121,872,000 108,748,000 96,400,000 83,314,000 77,973,000 74,627,000 59,541,000 55,837,000 52,722,000 46,340,000 55,508,000 54,876,000 42,762,000 48,259,000 49,283,000 52,898,000 43,218,000 31,860,000 29,387,000 32,581,000 30,446,000 39,289,000 67,647,000 44,135,000 26,159,000 21,527,000 
      income from operations
    		29,267,000 19,768,000 24,021,000 20,160,000 13,272,000 -19,299,000 -9,658,000 -117,000 -16,542,000 81,000 -10,927,000 -3,154,000 -11,196,000 6,047,000 46,413,000 -19,368,000 -23,319,000 -36,131,000 -30,667,000 -40,555,000 -49,283,000 -52,898,000 -43,218,000 -31,860,000 -29,387,000 -32,581,000 -30,446,000 -39,289,000 -67,647,000 -44,135,000 -26,159,000  
      yoy
    		120.52% -202.43% -348.72% -17330.77% -180.23% -23925.93% -11.61% -96.29% 47.75% -98.66% -123.54% -83.72% -51.99% -116.74% -251.35% -52.24% -52.68% -31.70% -29.04% 27.29% 67.70% 62.36% 41.95% -18.91% -56.56% -26.18% 16.39%      
      qoq
    		48.05% -17.71% 19.15% 51.90% -168.77% 99.82% 8154.70% -99.29% -20522.22% -100.74% 246.45% -71.83% -285.15% -86.97% -339.64% -16.94% -35.46% 17.82% -24.38% -17.71% -6.83% 22.40% 35.65% 8.42% -9.80% 7.01% -22.51% -41.92% 53.27% 68.72%   
      operating margin %
    		13.66% 9.78% 13.28% 12.86% 9.63% -15.75% -8.61% -0.11% -20.71% 0.10% -16.30% -4.41% -23.16% 9.77% 46.82% -71.81% -72.44% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% 
      other income
    		3,414,000 3,501,000 3,136,000 2,717,000 2,293,000 2,320,000 2,457,000 2,421,000 2,266,000 2,369,000 2,428,000 1,915,000 1,832,000                    
      income before income taxes
    		32,681,000 23,269,000 27,157,000 22,877,000 15,565,000 -16,979,000 -7,201,000 2,304,000 -14,276,000 2,450,000 -8,499,000 -1,239,000 -9,364,000 6,841,000 46,735,000                  
      provision for income taxes
    		-10,089,000 -5,198,250 -8,722,000 -5,045,000 -7,026,000    -3,428,000    -2,906,000   -716,000 -1,925,000   -1,014,000             
      net income
    		22,592,000 14,199,000 18,435,000 17,832,000 8,539,000 -8,888,000 -12,693,000 -3,908,000 -17,704,000 25,237,000 -13,855,000 14,972,000 -12,270,000 4,461,000 224,093,000 -19,981,000 -25,210,000 -36,333,000 -30,544,000 -41,563,000 -49,484,000 -53,657,000 -43,836,000 -37,469,000 -26,419,000 -31,797,000 -27,058,000 -37,191,000 -65,821,000    
      yoy
    		164.57% -259.75% -245.24% -556.29% -148.23% -135.22% -8.39% -126.10% 44.29% 465.73% -106.18% -174.93% -51.33% -112.28% -833.67% -51.93% -49.05% -32.29% -30.32% 10.93% 87.30% 68.75% 62.01% 0.75% -59.86%        
      qoq
    		59.11% -22.98% 3.38% 108.83% -196.07% -29.98% 224.80% -77.93% -170.15% -282.15% -192.54% -222.02% -375.05% -98.01% -1221.53% -20.74% -30.61% 18.95% -26.51% -16.01% -7.78% 22.40% 16.99% 41.83% -16.91% 17.51% -27.25% -43.50%     
      net income margin %
    		10.54% 7.02% 10.19% 11.37% 6.20% -7.25% -11.31% -3.60% -22.17% 30.26% -20.66% 20.95% -25.38% 7.21% 226.05% -74.08% -78.32% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% 
      net income per share
    		0.3 0.19 0.25 0.24 0.12 -0.12 -0.18 -0.06 -0.25 0.36 -0.2 0.21 -0.18 0.06 3.23 -0.29 -0.36 -0.52 -0.44 -0.61 -0.72 -0.81 -0.66 -0.65 -0.48 -0.57 -0.49 -0.68 -1.27 -0.87 -0.51 -0.97 
      weighted-average ordinary shares outstanding—basic
    		76,516,535 74,200,924 74,714,846 73,438,530 72,647,121 71,424,159  71,004,640                         
      weighted-average ordinary shares outstanding—diluted
    		82,409,703 78,979,030 80,035,400 77,942,082 76,145,617 71,424,159  71,004,640                         
      comprehensive income
    		                                
      other comprehensive loss
    		                                
      unrealized loss on short-term investments and currency translation adjustments, net of tax
    		-640    -2             -2.75 -72              
      total other comprehensive loss
    		-640    -2             -2.75 -72              
      total comprehensive income
    		21,952 14,329 18,333 17,944 8,537   -3,985  25,244 -13,869 14,930  4,575 224,113                  
      other comprehensive income
    		                                
      unrealized gain on short-term investments and currency translation adjustments, net of tax
    		 130 -102 112  -122 89 -77 -59 7 -14 -42 11 114 20 13 -37   48 13 -40 -3 -231 207 -29 -39      
      total other comprehensive income
    		 130 -102 112  -122 89 -77 -59 7 -14 -42  114 20     48 13 -40 -3 -231 207 -29 -39 93 12    
      benefit for income taxes
    		     8,091,000 -5,492,000 -6,212,000  22,787,000 -5,356,000 16,211,000  -2,380,000 177,358,000   -279,000 118,000  -210,000 -789,000 -667,000 -5,875,000 2,179,000 -346,000 2,002,000 374,000 17,000 -172,000 131,000  
      weighted-average ordinary shares outstanding—basic and diluted
    		      71,726,685                          
      comprehensive loss:
    		                                
      other comprehensive income:
    		                                
      total comprehensive loss
    		     -8,588 -12,604  -17,763    -12,259   -19,968 -25,247 -36,354 -30,616 -41,515 -49,471 -53,697 -43,839 -37,700 -26,212 -31,826 -27,097 -37,098 -65,809    
      comprehensive income:
    		                                
      weighted-average common shares outstanding—basic and diluted
    		        70,633,023    69,751,697   69,289,972 69,136,901 68,576,810 68,662,673 68,395,703 68,269,486 61,842,722 65,958,513 57,914,105 55,322,690 54,049,477 54,831,308 54,475,476 51,758,353 29,547,427 48,183,424 20,787,288 
      weighted-average common shares outstanding—basic
    		         70,058,952 70,186,016 69,918,287  69,382,275 69,445,071                  
      weighted-average common shares outstanding—diluted
    		         71,922,915 70,186,016 71,634,729  70,421,322 70,552,018                  
      other comprehensive loss:
    		                                
      total other comprehensive gain
    		            11   13 -37                
      interest income
    		             114,750 322,000 103,000 34,000 77,000 5,000 6,000 9,000 30,000 49,000 266,000 789,000 1,130,000 1,386,000 1,724,000 1,809,000 1,727,000 1,622,000 1,066,000 
      collaboration revenue
    		                10,000,000                
      income before provision for income taxes
    		               -19,265,000 -23,285,000   -40,549,000             
      loss before benefit for income taxes
    		                 -36,054,000 -30,662,000  -49,274,000 -52,868,000 -43,169,000 -31,594,000 -28,598,000 -31,451,000 -29,060,000 -37,565,000 -65,838,000    
      operating expenses:
    		                                
      general and administrative
    		                     7,455,250 11,799,000 9,536,000 8,486,000 9,695,000 8,432,000 8,441,000 8,394,000 8,013,000 5,515,000 4,327,000 
      unrealized gain on short-term investments
    		                           93 12    
      income before benefit from income taxes
    		                             -15,258,250 -24,537,000  
      net income and comprehensive loss
    		                             -15,161,750 -24,406,000 -20,259,000 
      benefit (provision) for income taxes
    		                               202,000 
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 
                                      
        assets
      		                                
        current assets:
      		                                
        cash and cash equivalents
      		189,952,000 165,596,000 174,858,000 192,037,000 157,132,000 183,581,000 97,376,000 99,271,000 141,078,000 107,954,000 117,828,000 112,567,000 80,618,000 122,715,000 175,761,000 94,307,000 63,324,000 122,470,000 190,183,000 167,953,000 119,856,000 114,038,000 85,874,000 123,456,000 106,336,000 46,928,000 68,809,000 82,810,000 82,629,000 71,976,000 69,663,000 285,518,000 
        short-term investments
      		278,141,000 248,478,000 177,244,000 115,745,000 111,208,000 60,046,000 126,404,000 119,487,000 72,474,000 98,417,000 83,256,000 72,425,000 106,876,000 67,893,000 24,963,000 43,901,000 82,253,000 59,731,000 10,000,000 57,913,000 144,169,000 209,444,000 278,521,000 128,942,000 97,870,000 186,452,000 189,936,000 204,637,000 243,904,000 235,328,000 268,200,000 73,672,000 
        accounts receivable
      		23,224,000 15,594,000 51,742,000 31,910,000 40,065,000 41,724,000 24,888,000 20,451,000 15,995,000 21,266,000 3,041,000 24,650,000 7,424,000 12,660,000 11,159,000 7,808,000 29,440,000 3,985,000 3,224,000 2,551,000             
        inventory
      		73,141,000 54,895,000 41,396,000 48,181,000 22,069,000 26,364,000 28,680,000 34,858,000 27,278,000 31,122,000 25,583,000 23,958,000 23,425,000 21,599,000 14,621,000 19,916,000 13,223,000 3,675,000 5,606,000 6,381,000 2,189,000            
        prepaid expenses and other current assets
      		29,714,000 42,614,000 30,290,000 32,438,000 25,433,000 20,084,000 33,953,000 26,954,000 13,766,000 17,538,000 26,401,000 12,440,000 13,157,000 10,537,000 15,311,000 14,006,000 10,517,000 6,585,000 8,499,000 9,802,000 9,140,000 9,557,000 14,018,000 12,095,000 8,849,000 8,247,000 9,595,000 9,011,000 8,423,000 6,446,000 3,665,000 4,416,000 
        total current assets
      		594,172,000 527,177,000 475,530,000 420,311,000 355,907,000 331,799,000 311,301,000 301,021,000 270,591,000 276,297,000 256,109,000 246,040,000 231,500,000 243,060,000 241,815,000 179,938,000 198,757,000 196,446,000 217,512,000 244,810,000 275,564,000 333,249,000 378,413,000 264,493,000 213,055,000 241,627,000 268,340,000 296,458,000 334,956,000 313,750,000 341,528,000 363,869,000 
        property and equipment
      		1,986,000 1,943,000 1,655,000 1,076,000 606,000 662,000 561,000 625,000 712,000 734,000 918,000 1,136,000 1,393,000 1,658,000 1,995,000 2,150,000 2,475,000 2,834,000 3,168,000 3,449,000 3,815,000 4,051,000 4,573,000 5,210,000 5,804,000 6,398,000 6,409,000 6,359,000 6,190,000 6,356,000 2,360,000 350,000 
        operating lease right-of-use assets
      		9,334,000 9,807,000 10,073,000 10,304,000 10,453,000 10,376,000 11,095,000 11,779,000 12,324,000 11,931,000 12,668,000 13,191,000 5,228,000 5,385,000 6,173,000 4,069,000 4,815,000 5,550,000 6,128,000 5,386,000 5,982,000 6,566,000 1,166,000 1,323,000 1,629,000 1,927,000 2,218,000 2,503,000 3,347,000    
        other long-term assets
      		11,162,000 11,307,000 8,288,000 8,195,000 8,202,000 10,315,000 7,853,000 7,904,000 4,128,000 827,000 2,294,000 2,353,000 2,323,000 5,824,000 5,627,000 5,669,000 5,918,000 8,720,000 6,551,000 5,813,000 5,797,000 5,588,000 48,000          
        intangible asset
      		15,000,000 15,250,000 15,500,000 15,750,000 16,000,000 16,250,000 16,500,000 16,750,000 17,000,000 17,250,000 17,500,000 17,750,000 18,000,000 18,250,000 18,500,000 18,750,000 19,000,000 19,250,000 19,500,000 19,750,000 20,000,000            
        deferred tax assets
      		193,626,000 198,149,000 201,287,000 205,514,000 208,158,000 211,151,000 207,988,000 204,349,000 214,918,000 219,283,000 193,574,000 203,862,000 184,418,000 185,495,000 185,843,000       10,000 3,000  5,410,000 4,372,000 4,628,000 2,607,000 1,456,000 1,216,000 1,173,000 700,000 
        total assets
      		825,280,000 763,633,000 712,333,000 661,150,000 599,326,000 580,553,000 555,298,000 542,428,000 519,673,000 526,322,000 483,063,000 484,332,000 442,862,000 459,672,000 459,953,000 210,576,000 230,965,000 232,800,000 252,859,000 279,208,000 311,158,000 349,464,000 384,413,000 271,441,000 226,108,000 254,534,000 281,805,000 308,137,000 346,159,000 321,965,000 347,101,000 365,129,000 
        liabilities and shareholders’ equity
      		                                
        current liabilities:
      		                                
        accounts payable
      		24,402,000 2,028,000 6,150,000 8,956,000 1,982,000 2,039,000 8,328,000 7,393,000 5,632,000 8,246,000 1,012,000 648,000 1,391,000 7,899,000 1,469,000 2,522,000 3,383,000 1,868,000 1,649,000 4,156,000 2,763,000 503,000 3,925,000 2,373,000 4,274,000 5,693,000 6,440,000 9,338,000 6,890,000 10,918,000 4,668,000 561,000 
        accrued collaboration expenses
      		75,577,000 70,015,000 63,282,000 52,389,000 53,775,000 48,157,000 29,148,000 29,943,000                         
        accrued expenses
      		32,771,000 42,020,000 30,941,000 35,959,000 22,126,000 32,355,000 40,379,000 33,374,000 44,718,000 44,667,000 41,149,000 35,316,000 20,885,000 30,112,000 30,868,000 34,500,000 38,887,000 38,031,000 28,528,000 31,064,000 30,316,000 29,199,000 19,475,000 16,499,000 13,379,000 20,415,000 19,360,000 19,179,000 15,618,000 16,418,000 13,353,000 12,583,000 
        operating lease liabilities
      		3,170,000 2,987,000 2,696,000 2,522,000 2,292,000 1,993,000 2,031,000 2,085,000 2,279,000 2,253,000 2,313,000 2,238,000 3,482,000 3,301,000 3,274,000 3,336,000 3,311,000 3,381,000 3,246,000 2,636,000 2,374,000 2,107,000 1,492,000 1,680,000 1,689,000 1,697,000 1,610,000 1,496,000 1,384,000    
        other current liabilities
      		20,691,000 22,134,000 20,523,000 18,001,000 17,092,000 16,077,000 16,069,000 11,484,000 11,427,000 8,193,000 6,430,000 4,596,000 4,334,000 5,754,000 8,789,000 3,186,000 4,773,000 1,544,000 1,004,000 926,000  37,000    25,000  165,000  218,000   
        total current liabilities
      		156,611,000 139,184,000 123,592,000 117,827,000 97,267,000 100,621,000 95,955,000 84,291,000 64,212,000 63,666,000 53,468,000 47,472,000 36,587,000 47,066,000 56,492,000 43,544,000 50,354,000 44,824,000 34,427,000 38,782,000 35,453,000 31,846,000 24,892,000 20,552,000 19,342,000 27,830,000 27,560,000 30,178,000 36,892,000 42,554,000 28,021,000 23,144,000 
        non-current liabilities:
      		                                
        non-current deferred revenue
      		31,811,000 31,811,000 31,811,000 31,811,000 31,811,000 31,811,000 11,811,000 11,799,000 11,811,000 11,954,000 11,872,000 12,006,000 12,163,000 12,000,000 14,198,000                  
        non-current operating lease liabilities
      		5,855,000 6,510,000 7,022,000 7,243,000 7,623,000 7,862,000 8,564,000 9,317,000 9,864,000 10,005,000 10,651,000 11,283,000 2,133,000 2,618,000 3,435,000 1,278,000 2,096,000 2,669,000 3,499,000 3,500,000 4,200,000 4,878,000 55,000 139,000 551,000        
        other long-term liabilities
      		25,316,000 18,522,000 14,525,000 9,262,000 5,136,000 1,823,000 1,962,000 1,926,000 1,891,000 1,858,000 1,945,000 1,915,000 1,884,000 1,839,000 1,820,000 260,000 271,000 270,000 885,000 1,141,000 809,000 805,000 957,000 334,000 381,000 326,000 943,000 943,000 509,000    
        total liabilities
      		219,593,000 196,027,000 176,950,000 166,143,000 141,837,000 142,117,000 118,292,000 107,333,000 87,778,000 87,483,000 77,936,000 72,676,000 52,767,000 63,523,000 75,945,000 57,082,000 64,721,000 47,763,000 38,811,000 43,423,000 40,462,000 37,529,000 25,904,000 21,025,000 20,274,000 29,111,000 29,894,000 32,940,000 39,640,000 42,698,000 28,188,000 23,330,000 
        commitments and contingencies
      		                                
        shareholders’ equity:
      		                                
        class a ordinary shares, nominal value of 0.000273235 per share; 46,054,720 shares and 45,659,424 shares issued and outstanding as of march 31, 2026 and december 31, 2025, respectively
      		12,000                                
        class b ordinary shares, nominal value of 0.000273235 per share; 1,795,158 shares issued and outstanding as of march 31, 2026 and december 31, 2025
      		1,000                                
        class a1 ordinary shares, nominal value of 0.000273235 per share; 12,781,964 shares issued and outstanding as of march 31, 2026 and december 31, 2025
      		4,000                                
        class b1 ordinary shares, 0.000273235 nominal value; 16,057,618 shares issued and outstanding as of march 31, 2026 and december 31, 2025
      		4,000                                
        additional paid-in capital
      		1,045,877,000 1,029,748,000 1,011,854,000 989,811,000 970,238,000 959,722,000 949,282,000 934,767,000 927,582,000 916,763,000 908,295,000 900,956,000 894,325,000 888,120,000 880,554,000 874,153,000 866,935,000 860,482,000 853,139,000 844,260,000 837,656,000 829,424,000 822,301,000 670,371,000 588,090,000 581,467,000 576,129,000 572,318,000 566,542,000 473,483,000 470,600,000 469,018,000 
        accumulated other comprehensive loss
      		-665,000 -25,000 -155,000 -53,000 -165,000          -70,000 -90,000 -103,000 -66,000   -21,000            
        accumulated deficit
      		-439,546,000 -462,138,000 -476,337,000 -494,772,000 -512,604,000 -521,143,000 -512,255,000 -499,562,000 -495,654,000 -477,950,000 -503,187,000 -489,332,000 -504,304,000 -492,034,000 -496,495,000 -720,588,000 -700,607,000 -675,397,000 -639,064,000 -608,520,000 -566,957,000 -517,473,000 -463,816,000 -419,980,000 -382,511,000 -356,092,000 -324,295,000 -297,237,000 -260,046,000 -194,225,000 -151,645,000  
        total shareholders’ equity
      		605,687,000 567,606,000 535,383,000 495,007,000 457,489,000 438,436,000 437,006,000 435,095,000 431,895,000 438,839,000 405,127,000 411,656,000 390,095,000 396,149,000 384,008,000 153,494,000 166,244,000 185,037,000 214,048,000 235,785,000 270,696,000 311,935,000 358,509,000 250,416,000 205,834,000 225,423,000 251,911,000 275,197,000 306,519,000 279,267,000 318,913,000 341,799,000 
        total liabilities and shareholders’ equity
      		825,280,000 763,633,000 712,333,000 661,150,000 599,326,000 580,553,000 555,298,000 542,428,000 519,673,000 526,322,000 483,063,000 484,332,000 442,862,000 459,672,000 459,953,000 210,576,000 230,965,000 232,800,000 252,859,000 279,208,000 311,158,000 349,464,000 384,413,000 271,441,000 226,108,000 254,534,000 281,805,000 308,137,000 346,159,000    
        class a ordinary shares, par value of 0.000273235 per share; 45,659,424 shares and 41,881,319 shares issued and outstanding as of december 31, 2025 and 2024, respectively
      		 12,000                               
        class b ordinary shares, par value of 0.000273235 per share; 1,795,158 shares issued and outstanding as of december 31, 2025 and 2024
      		 1,000                               
        class a1 ordinary shares, 0.000273235 par value; 12,781,964 shares issued and outstanding as of december 31, 2025 and 2024
      		 4,000                               
        class b1 ordinary shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of december 31, 2025 and 2024
      		 4,000                               
        class a ordinary shares, nominal value of 0.000273235 per share; 44,789,913 shares and 41,881,319 shares issued and outstanding as of september 30, 2025 and december 31, 2024, respectively
      		  12,000                              
        class b ordinary shares, nominal value of 0.000273235 per share; 1,795,158 shares issued and outstanding as of september 30, 2025 and december 31, 2024
      		  1,000                              
        class a1 ordinary shares, nominal value of 0.000273235 per share; 12,781,964 shares issued and outstanding as of september 30, 2025 and december 31, 2024
      		  4,000                              
        class b1 ordinary shares, 0.000273235 nominal value; 16,057,618 shares issued and outstanding as of september 30, 2025 and december 31, 2024
      		  4,000                              
        class a ordinary shares, nominal value of 0.000273235 per share; 43,397,623 shares and 41,881,319 shares issued and outstanding as of june 30, 2025 and december 31, 2024, respectively
      		   12,000                             
        class b ordinary shares, nominal value of 0.000273235 per share; 1,795,158 shares issued and outstanding as of june 30, 2025 and december 31, 2024
      		   1,000                             
        class a1 ordinary shares, nominal value of 0.000273235 per share; 12,781,964 shares issued and outstanding as of june 30, 2025 and december 31, 2024
      		   4,000                             
        class b1 ordinary shares, 0.000273235 nominal value; 16,057,618 shares issued and outstanding as of june 30, 2025 and december 31, 2024
      		   4,000                             
        class a ordinary shares, nominal value of 0.000273235 per share; 42,162,592 shares and 41,881,319 shares issued and outstanding as of march 31, 2025 and december 31, 2024, respectively
      		    11,000                            
        class b ordinary shares, nominal value of 0.000273235 per share; 1,795,158 shares issued and outstanding as of march 31, 2025 and december 31, 2024
      		    1,000                            
        class a1 ordinary shares, nominal value of 0.000273235 per share; 12,781,964 shares issued and outstanding as of march 31, 2025 and december 31, 2024
      		    4,000                            
        class b1 ordinary shares, 0.000273235 nominal value; 16,057,618 shares issued and outstanding as of march 31, 2025 and december 31, 2024
      		    4,000                            
        deferred revenue
      		       12,000 156,000 307,000 2,564,000 4,674,000 6,495,000  12,092,000 12,000,000 12,000,000                
        class a ordinary shares, par value of 0.000273235 per share; 41,881,319 shares and 35,781,373 shares issued and outstanding as of december 31, 2024 and 2023, respectively
      		     11,000                           
        class b ordinary shares, par value of 0.000273235 per share; 1,795,158 shares issued and outstanding as of december 31, 2024 and 2023
      		     1,000                           
        class a1 ordinary shares, 0.000273235 par value; 12,781,964 shares and 16,826,468 issued and outstanding as of december 31, 2024 and 2023, respectively
      		     4,000                           
        class b1 ordinary shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of december 31, 2024 and 2023
      		     4,000                           
        accumulated other comprehensive income
      		     -163,000 -41,000 -130,000 -53,000 6,000 -1,000 13,000 55,000 44,000     -45,000 27,000  -34,000 6,000 9,000 240,000 33,000 62,000 101,000 8,000  -55,000 7,000 
        class a ordinary shares, nominal value of 0.000273235 per share; 41,523,449 shares and 35,781,373 shares issued and outstanding as of september 30, 2024 and december 31, 2023, respectively
      		      11,000                          
        class b ordinary shares, nominal value of 0.000273235 per share; 1,795,158 shares issued and outstanding as of september 30, 2024 and december 31, 2023
      		      1,000                          
        class a1 ordinary shares, 0.000273235 nominal value; 12,781,964 and 16,826,468 shares issued and outstanding as of september 30, 2024 and december 31, 2023, respectively
      		      4,000                          
        class b1 ordinary shares, 0.000273235 nominal value; 16,057,618 shares issued and outstanding as of september 30, 2024 and december 31, 2023
      		      4,000                          
        class a ordinary shares, nominal value of 0.000273235 per share; 40,447,538 shares and 35,781,373 shares issued and outstanding as of june 30, 2024 and december 31, 2023, respectively
      		       11,000                         
        class b ordinary shares, nominal value of 0.000273235 per share; 1,795,158 shares issued and outstanding as of june 30, 2024 and december 31, 2023
      		       1,000                         
        class a1 ordinary shares, 0.000273235 nominal value; 12,781,964 and 16,826,468 shares issued and outstanding as of june 30, 2024 and december 31, 2023, respectively
      		       4,000                         
        class b1 ordinary shares, 0.000273235 nominal value; 16,057,618 shares issued and outstanding as of june 30, 2024 and december 31, 2023
      		       4,000                         
        class a common shares, par value of 0.000273235 per share; 40,184,356 shares and 35,781,373 shares issued and outstanding as of march 31, 2024 and december 31, 2023, respectively
      		        11,000                        
        class b common shares, par value of 0.000273235 per share; 1,795,158 shares issued and outstanding as of march 31, 2024 and december 31, 2023
      		        1,000                        
        class a1 common shares, 0.000273235 par value; 12,781,964 and 16,826,468 shares issued and outstanding as of march 31, 2024 and december 31, 2023, respectively
      		        4,000                        
        class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of march 31, 2024 and december 31, 2023
      		        4,000                        
        contract asset
      		             7,656,000                   
        class a common shares, par value of 0.000273235 per share; 35,781,373 shares and 34,750,560 shares issued and outstanding as of december 31, 2023 and 2022, respectively
      		         10,000                       
        class b common shares, par value of 0.000273235 per share; 1,795,158 shares and 1,813,457 shares issued and outstanding as of december 31, 2023 and 2022, respectively
      		         1,000                       
        class a1 common shares, 0.000273235 par value; 16,826,468 shares and 17,075,868 issued and outstanding as of december 31, 2023 and 2022, respectively
      		         5,000                       
        class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of december 31, 2023 and 2022
      		         4,000                       
        class a common shares, par value of 0.000273235 per share; 35,387,987 shares and 34,750,560 shares issued and outstanding as of september 30, 2023 and december 31, 2022, respectively
      		          10,000                      
        class b common shares, par value of 0.000273235 per share; 1,795,158 shares and 1,813,457 shares issued and outstanding as of september 30, 2023 and december 31, 2022, respectively
      		          1,000                      
        class a1 common shares, 0.000273235 par value; 17,075,868 shares issued and outstanding as of september 30, 2023 and december 31, 2022
      		          5,000                      
        class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of september 30, 2023 and december 31, 2022
      		          4,000                      
        class a common shares, par value of 0.000273235 per share; 35,074,019 shares and 34,750,560 shares issued and outstanding as of june 30, 2023 and december 31, 2022, respectively
      		           9,000                     
        class b common shares, par value of 0.000273235 per share; 1,795,158 shares and 1,813,457 shares issued and outstanding as of june 30, 2023 and december 31, 2022, respectively
      		           1,000                     
        class a1 common shares, 0.000273235 par value; 17,075,868 shares issued and outstanding as of june 30, 2023 and december 31, 2022
      		           5,000                     
        class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of june 30, 2023 and december 31, 2022
      		           4,000                     
        class a common shares, par value of 0.000273235 per share; 34,886,136 shares and 34,750,560 shares issued and outstanding as of march 31, 2023 and december 31, 2022, respectively
      		            9,000                    
        class b common shares, par value of 0.000273235 per share; 1,813,457 shares issued and outstanding as of march 31, 2023 and december 31, 2022
      		            1,000                    
        class a1 common shares, 0.000273235 par value; 17,075,868 shares issued and outstanding as of march 31, 2023 and december 31, 2022
      		            5,000                    
        class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of march 31, 2023 and december 31, 2022
      		            4,000                    
        class a common shares, par value of 0.000273235 per share; 34,750,560 shares and 34,059,725 shares issued and outstanding as of december 31, 2022 and 2021, respectively
      		             9,000                   
        class b common shares, par value of 0.000273235 per share; 1,813,457 shares issued and outstanding as of december 31, 2022 and 2021
      		             1,000                   
        class a1 common shares, 0.000273235 par value; 17,075,868 shares and 17,129,603 issued and outstanding as of december 31, 2022 and 2021, respectively
      		             5,000                   
        class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of december 31, 2022 and 2021
      		             4,000                   
        class a common shares, par value of 0.000273235 per share; 34,523,660 shares and 34,059,725 shares issued and outstanding as of september 30, 2022 and december 31, 2021, respectively
      		              9,000                  
        class b common shares, par value of 0.000273235 per share; 1,813,457 shares issued and outstanding as of september 30, 2022 and december 31, 2021
      		              1,000                  
        class a1 common shares, 0.000273235 par value; 17,129,603 shares issued and outstanding as of september 30, 2022 and december 31, 2021
      		              5,000                  
        class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of september 30, 2022 and december 31, 2021
      		              4,000                  
        class a common shares, par value of 0.000273235 per share; 34,426,089 shares and 34,059,725 shares issued and outstanding as of june 30, 2022 and december 31, 2021, respectively
      		               9,000                 
        class b common shares, par value of 0.000273235 per share; 1,813,457 shares issued and outstanding as of june 30, 2022 and december 31, 2021
      		               1,000                 
        class a1 common shares, 0.000273235 par value; 17,129,603 shares issued and outstanding as of june 30, 2022 and december 31, 2021
      		               5,000                 
        class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of june 30, 2022 and december 31, 2021
      		               4,000                 
        class a common shares, par value of 0.000273235 per share; 34,270,445 shares and 34,059,725 shares issued and outstanding as of march 31, 2022 and december 31, 2021, respectively
      		                9,000                
        class b common shares, par value of 0.000273235 per share; 1,813,457 shares issued and outstanding as of march 31, 2022 and december 31, 2021
      		                1,000                
        class a1 common shares, 0.000273235 par value; 17,129,603 shares issued and outstanding as of march 31, 2022 and december 31, 2021
      		                5,000                
        class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of march 31, 2022 and december 31, 2021
      		                4,000                
        restricted cash
      		                   210,000 210,000 210,000 210,000 210,000 210,000 210,000 210,000 210,000 210,000   263,000 
        class a common shares, par value of 0.000273235 per share; 34,059,725 shares and 31,777,420 shares issued and outstanding as of december 31, 2021 and 2020, respectively
      		                 8,000               
        class b common shares, par value of 0.000273235 per share; 1,813,457 shares and 2,355,458 shares issued and outstanding as of december 31, 2021 and 2020, respectively
      		                 1,000               
        class a1 common shares, 0.000273235 par value; 17,129,603 shares and 18,024,526 issued and outstanding as of december 31, 2021 and 2020, respectively
      		                 5,000               
        class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of december 31, 2021 and 2020
      		                 4,000               
        class a common shares, par value of 0.000273235 per share; 32,992,834 shares and 31,777,420 shares issued and outstanding as of september 30, 2021 and december 31, 2020, respectively
      		                  8,000              
        class b common shares, par value of 0.000273235 per share; 1,813,457 shares and 2,355,458 shares issued and outstanding as of september 30, 2021 and december 31, 2020, respectively
      		                  1,000              
        class a1 common shares, 0.000273235 par value; 18,024,526 issued and outstanding as of september 30, 2021 and december 31, 2020
      		                  5,000              
        class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of september 30, 2021 and december 31, 2020
      		                  4,000              
        class a common shares, par value of 0.000273235 per share; 32,569,148 shares and 31,777,420 shares issued and outstanding as of june 30, 2021 and december 31, 2020, respectively
      		                   8,000             
        class b common shares, par value of 0.000273235 per share; 1,813,457 shares and 2,355,458 shares issued and outstanding as of june 30, 2021 and december 31, 2020, respectively
      		                   1,000             
        class a1 common shares, 0.000273235 par value; 18,024,526 issued and outstanding as of june 30, 2021 and december 31, 2020
      		                   5,000             
        class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of june 30, 2021 and december 31, 2020
      		                   4,000             
        class a common shares, par value of 0.000273235 per share; 32,320,276 shares and 31,777,420 shares issued and outstanding as of march 31, 2021 and december 31, 2020, respectively
      		                    8,000            
        class b common shares, par value of 0.000273235 per share; 1,927,614 shares and 2,355,458 shares issued and outstanding as of march 31, 2021 and december 31, 2020, respectively
      		                    1,000            
        class a1 common shares, 0.000273235 par value; 18,024,526 issued and outstanding as of march 31, 2021 and december 31, 2020
      		                    5,000            
        class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of march 31, 2021 and december 31, 2020
      		                    4,000            
        non-current restricted cash
      		                                
        class a common shares, par value of 0.000273235 per share; 31,777,420 shares and 19,245,201 shares issued and outstanding as of december 31, 2020 and 2019, respectively
      		                     8,000           
        class b common shares, par value of 0.000273235 per share; 2,355,458 shares and 4,638,855 shares issued and outstanding as of december 31, 2020 and 2019, respectively
      		                     1,000           
        class a1 common shares, 0.000273235 par value; 18,024,526 shares and 14,995,954 issued and outstanding as of december 31, 2020 and 2019, respectively
      		                     5,000           
        class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of december 31, 2020 and 2019
      		                     4,000           
        class a common shares, par value of 0.000273235 per share; 31,479,648 shares and 19,245,201 shares issued and outstanding as of september 30, 2020 and december 31, 2019, respectively
      		                      8,000          
        class b common shares, par value of 0.000273235 per share; 2,355,458 shares and 4,638,855 shares issued and outstanding as of september 30, 2020 and december 31, 2019, respectively
      		                      1,000          
        class a1 common shares, 0.000273235 par value; 18,024,526 shares and 14,995,954 issued and outstanding as of september 30, 2020 and december 31, 2019, respectively
      		                      5,000          
        class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of september 30, 2020 and december 31, 2019
      		                      4,000          
        deferred offering costs
      		                       205,000      433,000   
        class a common shares, par value of 0.000273235 per share; 25,369,973 shares and 19,245,201 shares issued and outstanding as of june 30, 2020 and december 31, 2019, respectively
      		                       7,000         
        class b common shares, par value of 0.000273235 per share; 2,463,011 shares and 4,638,855 shares issued and outstanding as of june 30, 2020 and december 31, 2019
      		                       1,000         
        class a1 common shares, 0.000273235 par value; 16,595,954 shares and 14,995,954 issued and outstanding as of june 30, 2020 and december 31, 2019, respectively
      		                       4,000         
        class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of june 30, 2020 and december 31, 2019
      		                       4,000         
        class a common shares, par value of 0.000273235 per share; 21,519,500 shares and 19,245,201 shares issued and outstanding as of march 31, 2020 and december 31, 2019, respectively
      		                        6,000        
        class b common shares, par value of 0.000273235 per share; 3,008,373 shares and 4,638,855 shares issued and outstanding as of march 31, 2020 and december 31, 2019
      		                        1,000        
        class a1 common shares, 0.000273235 par value; 14,995,954 shares issued and outstanding as of march 31, 2020 and december 31, 2019, respectively
      		                        4,000        
        class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of march 31, 2020 and december 31, 2019
      		                        4,000        
        accrued milestones
      		                          150,000  13,000,000 15,000,000   
        noncurrent liabilities:
      		                                
        noncurrent operating lease liabilities
      		                         955,000 1,391,000 1,819,000 2,239,000    
        class a common shares, par value of 0.000273235 per share; 19,245,201 shares and 15,797,220 shares issued and outstanding as of december 31, 2019 and december 31, 2018, respectively
      		                         6,000       
        class b common shares, par value of 0.000273235 per share; 4,638,855 shares issued and outstanding as of december 31, 2019 and december 31, 2018
      		                         1,000       
        class a1 common shares, 0.000273235 par value; 14,995,954 and 12,995,954 shares issued and outstanding as of december 31, 2019 and december 31, 2018, respectively
      		                         4,000       
        class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of december 31, 2019 and december 31, 2018
      		                         4,000       
        class a common shares, par value of 0.000273235 per share; 19,178,913 shares and 15,797,220 shares issued and outstanding as of september 30, 2019 and december 31, 2018, respectively
      		                          6,000      
        class b common shares, par value of 0.000273235 per share; 4,638,855 shares issued and outstanding as of september 30, 2019 and december 31, 2018
      		                          1,000      
        class a1 common shares, 0.000273235 par value; 14,995,954 shares and 12,995,954 shares issued and outstanding as of september 30, 2019 and december 31, 2018, respectively
      		                          4,000      
        class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of september 30, 2019 and december 31, 2018
      		                          4,000      
        class a common shares, par value of 0.000273235 per share; 19,165,265 shares and 15,797,220 shares issued and outstanding as of june 30, 2019 and december 31, 2018, respectively
      		                           6,000     
        class b common shares, par value of 0.000273235 per share; 4,638,855 shares issued and outstanding as of june 30, 2019 and december 31, 2018
      		                           1,000     
        class a1 common shares, 0.000273235 par value; 14,995,954 shares and 12,995,954 shares issued and outstanding as of june 30, 2019 and december 31, 2018, respectively
      		                           4,000     
        class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of june 30, 2019 and december 31, 2018
      		                           4,000     
        class a common shares, par value of 0.000273235 per share; 19,000,408 shares and 15,797,220 shares issued and outstanding as of march 31, 2019 and december 31, 2018, respectively
      		                            6,000    
        class b common shares, par value of 0.000273235 per share; 4,638,855 shares and 4,638,855 shares issued and outstanding as of march 31, 2019 and december 31, 2018, respectively
      		                            1,000    
        class a1 common shares, 0.000273235 par value; 14,995,954 shares and 12,995,954 shares issued and outstanding as of march 31, 2019 and december 31, 2018, respectively
      		                            4,000    
        class b1 common shares, 0.000273235 par value; 16,057,618 shares and 16,057,618 shares issued and outstanding as of march 31, 2019 and december 31, 2018, respectively
      		                            4,000    
        liabilities, convertible preferred shares and shareholders’ equity
      		                                
        deferred rent
      		                             144,000 167,000 186,000 
        convertible preferred shares (series a, b and c), 0.000273235 par value; 0 shares and 22,885,492 shares issued and outstanding as of december 31, 2018 and december 31, 2017, respectively; aggregate liquidation preference of 0 and 120,000 as of december 31, 2018 and december 31, 2017, respectively;
      		                                
        shareholders’ equity
      		                                
        class a common shares, par value of 0.000273235 per share; 15,797,220 shares and 719,976 shares issued and outstanding as of december 31, 2018 and december 31, 2017; respectively
      		                             4,000   
        class b common shares, par value of 0.000273235 per share; 4,638,855 shares and 3,568,353 shares issued and outstanding as of december 31, 2018 and december 31, 2017, respectively
      		                             1,000   
        class a1 common shares, 0.000273235 par value; 12,995,954 shares and 0 shares issued and outstanding as of december 31, 2018 and december 31, 2017, respectively
      		                             4,000   
        class b1 common shares, 0.000273235 par value; 16,057,618 shares and 0 shares issued and outstanding as of december 31, 2018 and december 31, 2017, respectively
      		                             4,000   
        total liabilities, convertible preferred shares and shareholders’ equity
      		                             321,965,000 347,101,000 365,129,000 
        advanced clinical payments
      		                              1,830,000  
        accrued milestone
      		                              10,000,000 10,000,000 
        convertible preferred shares (series a, b and c), 0.000273235 par value; 0 shares and 22,885,492 shares issued and outstanding as of september 30, 2018 and december 31, 2017, respectively; aggregate liquidation preference of 0 and 120,000 as of september 30, 2018 and december 31, 2017, respectively;
      		                                
        class a common shares, par value of 0.000273235 per share; 15,772,257 shares and 719,976 shares issued and outstanding as of september 30, 2018 and december 31, 2017; respectively
      		                              4,000  
        class b common shares, par value of 0.000273235 per share; 4,638,855 shares and 3,568,353 shares issued and outstanding as of september 30, 2018 and december 31, 2017, respectively
      		                              1,000  
        class a1 common shares, 0.000273235 par value; 12,995,954 shares and 0 shares issued and outstanding as of september 30, 2018 and december 31, 2017, respectively
      		                              4,000  
        class b1 common shares, 0.000273235 par value; 16,057,618 shares and 0 shares issued and outstanding as of september 30, 2018 and december 31, 2017, respectively
      		                              4,000  
        convertible preferred shares (series a, b and c), 0.000273235 par value; 0 shares and 22,885,492 shares issued and outstanding as of june 30, 2018 and december 31, 2017, respectively; aggregate liquidation preference of 0 and 120,000 as of june 30, 2018 and december 31, 2017, respectively;
      		                                
        class a common shares, par value of 0.000273235 per share; 15,754,771 shares and 719,976 shares issued and outstanding as of june 30, 2018 and december 31, 2017; respectively
      		                               4,000 
        class b common shares, par value of 0.000273235 per share; 4,638,855 shares and 3,568,353 shares issued and outstanding as of june 30, 2018 and december 31, 2017, respectively
      		                               1,000 
        class a1 common shares, 0.000273235 par value; 12,995,954 shares and 0 shares issued and outstanding as of june 30, 2018 and december 31, 2017, respectively
      		                               4,000 
        class b1 common shares, 0.000273235 par value; 16,057,618 shares and 0 shares issued and outstanding as of june 30, 2018 and december 31, 2017, respectively
      		                               4,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 
                                       
          cash flows from operating activities:
        		                               
          net income
        		22,592,000 14,199,000 18,435,000 17,832,000 8,539,000     25,237,000 -13,855,000   4,461,000                  
          adjustments to reconcile net income to net cash from operating activities
        		                               
          depreciation and amortization expense
        		468,000 467,000 384,000 358,000 345,000 400,000 399,000 430,000 466,000 540,000 603,000 602,000 596,000 602,000 493,000 651,000 656,000 668,000 658,000 717,000 312,000           
          share-based compensation expense
        		10,056,000 10,235,000 10,144,000 8,876,000 7,748,000 8,298,000 7,826,000 7,363,000 7,206,000 7,773,000 6,788,000 6,473,000 6,115,000 6,372,000 6,041,000 6,676,000 6,031,000 6,131,000 6,199,000 5,717,000 7,126,000 6,257,000 5,558,000 4,851,000 4,209,000 4,965,000 3,758,000 3,464,000 2,893,000 2,582,000 1,502,000 
          non-cash lease expense
        		994,000 963,000 944,000 924,000 835,000 767,000 754,000 836,000 779,000 737,000 707,000 769,000 841,000 788,000 772,000 746,000 735,000 736,000 702,000 600,000 593,000 639,000 158,000 303,000 300,000       
          net amortization of premiums and accretion of discounts on short-term investments
        		1,302,000  603,000                             
          net gain on disposal of property and equipment
        		-54,000  -43,000                             
          deferred income taxes
        		4,523,000 3,138,000 4,227,000 2,644,000 2,993,000 -3,163,000 -3,639,000 10,569,000 4,365,000 -25,709,000 10,288,000 -19,444,000 1,077,000 348,000       10,000 40,000 -51,000 5,410,000 -1,038,000 255,000 -2,021,000 -1,150,000 -240,000 -43,000  
          changes in operating assets and liabilities:
        		                               
          prepaid expenses and other current assets
        		13,049,000 -12,316,000 2,030,000 -6,868,000 -5,327,000 13,799,000 -6,992,000 -13,267,000 3,750,000 8,845,000 -13,987,000 709,000 -2,634,000 4,868,000 -1,305,000 -3,489,000 -3,932,000               
          accounts receivable
        		-7,630,000 36,148,000 -19,832,000 8,155,000 1,659,000 -16,836,000 -4,437,000 -4,456,000 5,271,000 -18,225,000 21,609,000 -17,226,000 5,236,000 -1,501,000 -3,351,000 21,632,000 -25,455,000 -686,000 -673,000             
          inventory
        		-18,246,000 -13,499,000 6,785,000 -26,112,000 4,295,000 2,316,000 6,178,000 -7,580,000 3,844,000 -5,539,000 -1,625,000 -533,000 -1,826,000 -6,978,000 5,295,000 -6,693,000 -9,548,000 1,931,000 775,000             
          other long-term assets
        		125,000 -3,042,000 -143,000 -70,000 2,045,000 -2,524,000 -10,000 -3,839,000 -3,362,000 1,406,000 0 -90,000 3,268,000 -265,000 1,000 163,000 2,755,000 -2,225,000 -780,000 -48,000 -231,000           
          accounts payable
        		22,266,000 -4,122,000 -2,728,000 6,930,000 62,000 -6,284,000 911,000 1,729,000 -2,662,000 7,234,000 364,000 -743,000 -6,508,000 6,430,000 -1,053,000 -861,000 1,515,000 250,000 -2,538,000 3,582,000 72,000 -3,265,000 1,524,000 -2,031,000 -1,197,000 -201,000 -2,841,000 1,680,000 -3,343,000 5,842,000  
          accrued expenses, accrued collaboration expenses and other current liabilities
        		-5,047,000 19,627,000 8,368,000 13,098,000 -3,596,000 10,993,000 10,796,000                         
          operating lease liabilities
        		-993,000 -918,000 -760,000 -925,000 -852,000 -788,000 -877,000 -1,032,000 -1,287,000 -706,000 -741,000 -826,000 -988,000 -790,000 -781,000 -793,000 -643,000 -853,000 -837,000 -442,000 -421,000 -594,000 -272,000 -420,000 -413,000 -348,000 -314,000 -309,000 -293,000   
          other long-term liabilities
        		6,794,000 3,997,000 5,263,000 4,126,000 3,313,000 -139,000 36,000 35,000 33,000 -87,000 30,000 31,000 45,000 19,000 1,560,000 -11,000 1,000 -615,000 -257,000 333,000 4,000 -152,000 623,000 -48,000 55,000 -617,000 0 434,000 509,000   
          net cash from operating activities
        		50,199,000 53,894,000 33,677,000 28,090,000 22,324,000 18,770,000 -2,236,000 5,168,000 3,987,000 4,325,000 16,986,000 -3,743,000 -4,267,000   -7,824,000 -36,846,000 -18,884,000 -28,509,000 -38,783,000 -40,122,000 -41,191,000 -34,321,000 -29,224,000 -31,796,000 -24,170,000 -29,267,000 -41,676,000 -63,256,000 -27,638,000  
          capital expenditures
        		-53,000 -633,000 -722,000 139,000 -65,000 -193,000 23,000 76,000 18,000 -56,000 -16,000 -34,000 -24,000   0  -251,000 -51,000 -59,000 -54,000 -55,000 -5,000 0 -223,000 -1,996,000 -440,000 794,000 -1,561,000 -4,016,000  
          free cash flows
        		50,146,000 53,261,000 32,955,000 28,229,000 22,259,000 18,577,000 -2,213,000 5,244,000 4,005,000 4,269,000 16,970,000 -3,777,000 -4,291,000   -7,824,000  -19,135,000 -28,560,000 -38,842,000 -40,176,000 -41,246,000 -34,326,000 -29,224,000 -32,019,000 -26,166,000 -29,707,000 -40,882,000 -64,817,000 -31,654,000  
          cash flows from investing activities:
        		                               
          purchases of property and equipment
        		-161,000 -633,000 -671,000 -165,000 -99,000 -193,000 0 0 -84,000 -56,000 -16,000 -34,000 -24,000 32,000 -22,000   -251,000 -51,000 -59,000 -54,000 -55,000 -5,000 0 -223,000 -1,996,000 -440,000 794,000 -1,561,000 -4,016,000  
          purchases of short-term investments
        		-177,411,000 -110,962,000 -146,160,000 -34,323,000 -95,470,000 -21,994,000 -54,481,000 -89,263,000 -36,276,000 -60,817,000 -53,088,000 -38,132,000 -52,896,000 -62,802,000 -17,328,000 -25,511,000 -30,223,000 -59,790,000 0 -23,098,000 -74,362,000 -86,052,000 -210,205,000 -107,767,000 -26,187,000 -82,638,000 -132,647,000 -91,681,000 -181,807,000 -109,424,000  
          proceeds from the maturities of short-term investments
        		145,656,000 40,781,000 84,076,000 30,605,000 44,028,000 87,480,000 48,133,000 42,441,000 61,884,000 45,979,000 40,827,000 73,700,000 15,000,000 20,100,000 36,400,000 63,800,000 7,500,000 10,000,000 47,900,000 109,150,000 139,250,000 154,750,000 60,550,000 76,550,000 115,200,000 86,550,000 148,300,000 132,250,000 174,090,000 143,100,000  
          net cash from investing activities
        		-31,916,000 -70,814,000 -62,755,000 -3,883,000 -51,541,000 65,293,000 -6,348,000 -46,797,000 25,524,000 -14,894,000   -37,920,000 -42,660,000 19,040,000 38,265,000 -22,723,000 -50,041,000 47,849,000 85,993,000 44,834,000 68,643,000 -149,660,000 -31,217,000 88,790,000 1,916,000 15,213,000 41,363,000 -9,278,000 29,660,000  
          cash flows from financing activities:
        		                               
          proceeds from issuance of class a ordinary shares under incentive award plans and employee share purchase plan
        		6,389,000 8,576,000 16,252,000 12,745,000 3,180,000 2,720,000 9,401,000                         
          payments in connection with ordinary shares tendered for employee tax obligations
        		-316,000  -4,353,000 -2,047,000 -412,000                           
          net cash from financing activities
        		6,073,000 7,658,000 11,899,000 10,698,000 2,768,000 2,142,000 6,689,000 -178,000 3,613,000 695,000 552,000 158,000 90,000 1,190,000 361,000 542,000 423,000 1,212,000 2,680,000 887,000 1,106,000 712,000 146,399,000 77,561,000 2,414,000 373,000 53,000 494,000 83,187,000 291,000  
          net increase in cash and cash equivalents
        		24,356,000   34,905,000 -26,449,000    33,124,000                       
          cash and cash equivalents at beginning of period
        		165,596,000 0 0 0 183,581,000 0 0 0 107,954,000  0 0 122,715,000                   
          cash and cash equivalents at end of period
        		189,952,000 -9,262,000 -17,179,000 34,905,000 157,132,000 86,205,000 -1,895,000 -41,807,000 141,078,000  5,261,000 31,949,000 80,618,000                   
          supplemental information:
        		                               
          cash paid for income taxes
        		 3,000 0 1,000 3,008,000 1,262,000 -769,000   -1,312,000 201,000 3,520,000 3,196,000 6,081,000 1,315,000   420,000 5,000   0 200,000   -3,000 700,000   38,000 197,000 
          supplemental disclosure of non-cash investing and financing activities:
        		                               
          change in right-of-use asset as a result of new, modified, and terminated leases
        		521,000 697,000 713,000 775,000 912,000 48,000 70,000 291,000 1,172,000 0 184,000                     
          additions to property and equipment included in accrued expenses and other liabilities
        		108,000                               
          adjustments to reconcile net income to net cash from operating activities:
        		                               
          net amortization of discounts on short-term investments
        		                               
          net loss on disposal of property and equipment
        		    10,000                           
          contract asset
        		         0 0 0 7,656,000                   
          deferred revenue
        		     20,000,000 -1,000 -155,000 -294,000 -2,175,000 -2,244,000 -1,978,000 6,658,000 -14,290,000 14,290,000 0 12,000,000               
          proceeds from sale of property and equipment
        		     0 0       10,000 -10,000                 
          payments in connection with ordinary stock tendered for employee tax obligations
        		     -578,000 -2,712,000                         
          net decrease in cash and cash equivalents
        		      -1,895,000    5,261,000 31,949,000 -42,097,000                   
          additions to property and equipment included in accounts payable and accrued expenses and other liabilities
        		  -51,000 304,000 34,000  23,000 76,000 102,000                       
          amortization of premiums and accretion of discounts on short-term investments
        		    255,000  -487,000 -188,000 297,000  1,441,000 -1,152,000 -1,061,000  -119,000 76,000 164,000  14,000 193,000 410,000           
          amortization of discounts on short-term investments
        		                               
          gain on disposal of property and equipment
        		     0 0                         
          loss on disposal of property and equipment
        		     0 0   4,000 0 0 175,000 10,000 -11,000           -2,000    0 0 
          net loss
        		        -17,704,000    -12,270,000   -19,981,000 -25,210,000 -36,333,000 -30,544,000 -41,563,000 -49,484,000 -53,657,000 -43,836,000 -37,469,000 -26,419,000 -31,797,000 -27,058,000 -37,191,000 -65,821,000 -42,580,000 -24,406,000 
          adjustments to reconcile net loss to net cash from operating activities:
        		                               
          accrued expenses and other current liabilities
        		        3,285,000 5,286,000 7,608,000 14,693,000 -10,647,000 -3,791,000 1,971,000 -5,974,000 4,085,000               
          proceeds from issuance of class a common shares under incentive award plans and employee share purchase plan
        		        3,994,000 957,000 1,657,000 577,000 510,000 1,290,000 569,000 566,000 992,000 1,212,000 2,680,000             
          payments in connection with common stock tendered for employee tax obligations
        		        -381,000 -262,000 -1,105,000 -419,000 -420,000 -100,000 -208,000 -24,000 -569,000               
          intangible assets acquired
        		                               
          net increase in cash, cash equivalents and restricted cash
        		             -53,046,000 81,454,000 30,983,000 -59,146,000 -67,713,000 22,020,000 48,097,000 5,818,000 28,164,000 -37,582,000 17,120,000 59,408,000       
          cash, cash equivalents and restricted cash at beginning of period
        		             0 0 0 122,470,000 0 0 0 114,248,000 0 0 0 47,138,000       
          cash, cash equivalents and restricted cash at end of period
        		             -53,046,000 81,454,000 30,983,000 63,324,000 -67,713,000 22,020,000 48,097,000 120,066,000 28,164,000 -37,582,000 17,120,000 106,546,000       
          net cash provided (used) in investing activities
        		                               
          right-of-use asset obtained in exchange for operating lease obligation
        		            684,000 0    157,000              
          proceeds from issuance of class a common shares from follow-on offerings, net of underwriting discounts and commissions, inclusive of the over-allotment option exercise
        		                     0          
          proceeds from issuance of class a1 common shares from private placements, net of placement agent fees
        		                     0          
          payments of offering costs
        		                     -160,000 -407,000   0 0 -18,000 -100,000   
          net cash provided (used) in operating activities
        		                               
          intangible asset acquired
        		                  0 0 -20,000,000           
          class a common shares issued as consideration for primatope, including milestone payments
        		                               
          accrued milestones
        		                         -150,000 150,000 -13,000,000 -2,000,000   
          property and equipment included in accrued expenses and accounts payable
        		                         -149,000 118,000 216,000 37,000 234,000  
          prepaid expenses and other assets
        		                  1,230,000 -604,000 408,000  -1,925,000 -3,245,000 -598,000     -764,000  
          accrued expenses and other liabilities
        		                  -2,458,000 1,674,000 1,079,000  3,177,000 2,915,000 -7,061,000 1,953,000 -35,000 3,096,000 -376,000   
          proceeds from issuance of class a common shares from follow-on offering, net of underwriting discounts and commissions, inclusive of the over-allotment option exercise
        		                               
          proceeds from issuance of class a1 common shares from private placement, net of placement fees
        		                               
          deferred offering costs included in accrued expenses and accounts payable
        		                      -181,000      19,000 393,000 -845,000 
          proceeds from issuance of class a common shares under incentive award plans
        		                    1,106,000           
          depreciation expense
        		                     567,000 649,000 595,000 594,000 566,000 523,000 508,000 471,000 254,000 12,000 
          other
        		                               
          prepaid expenses and other short-term assets
        		                               
          accrued expenses and other short-term liabilities
        		                               
          proceeds from issuance of series c convertible preferred shares, net of issuance costs
        		                             0 0 
          proceeds from issuance of class a common shares upon completion of initial public offering, net of underwriting discounts and commissions, inclusive of the over-allotment option exercise
        		                               
          class a common shares issued or to be issued as consideration for primatope, including milestone payments
        		                         0 0     
          accretion of discounts on short-term investments
        		                      74,000 -85,000 -228,000 -457,000 -989,000 -1,209,000 -846,000 -753,000  
          proceeds from exercise of options and employee share purchase plan
        		                      331,000 2,936,000 2,414,000 373,000 53,000 512,000 181,000   
          proceeds from issuance of class a1 common shares from private placement, net of placement agent fees
        		                               
          proceeds from issuance of class a common shares from follow-on offering, net of underwriting commissions and discounts, inclusive of the over-allotment option exercise
        		                         0 0 0 48,595,000   
          proceeds from issuance of class a1 common shares from private placement, net of underwriting commissions and discounts
        		                         0 0 0 34,511,000   
          proceeds from issuance of class a common shares upon completion of initial public offering, net of underwriting commissions and discounts, inclusive of the over-allotment option exercise
        		                               
          net increase in cash and cash equivalents and restricted cash
        		                         -21,881,000 -14,001,000 181,000 10,653,000 2,313,000 -216,118,000 
          cash, cash equivalents, and restricted cash at beginning of period
        		                               
          cash, cash equivalents, and restricted cash at end of period
        		                               
          non-cash rent expense
        		                             -23,000 50,000 
          prepaid expenses, right-of-use assets and other assets
        		                          -463,000 201,000 -1,210,000   
          cash and cash equivalents and restricted cash at beginning of period
        		                          0 0 72,186,000 0 0 
          cash and cash equivalents and restricted cash at end of period
        		                          -14,001,000 181,000 82,839,000 2,313,000 -216,118,000 
          class a common shares issued or to be issued as consideration for primatope
        		                            7,000,000   
          proceeds from issuance of series b convertible preferred shares, net of issuance costs
        		                               
          accrued expenses
        		                              833,000 
          proceeds from issuance of class a common shares upon completion of initial public offering, net of underwriting commissions and discounts
        		                              0 
          payments of deferred offering costs
        		                               
          proceeds from exercise of options
        		                              59,000 
          net cash provided by financing activities