7Baggers
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 
      
    		                              
      assets
    		                              
      current assets:
    		                              
      cash and cash equivalents
    		174,858,000 192,037,000 157,132,000 183,581,000 97,376,000 99,271,000 141,078,000 107,954,000 117,828,000 112,567,000 80,618,000 122,715,000 175,761,000 94,307,000 63,324,000 122,470,000 190,183,000 167,953,000 119,856,000 114,038,000 85,874,000 123,456,000 106,336,000 46,928,000 68,809,000 82,810,000 82,629,000 71,976,000 69,663,000 285,518,000 
      short-term investments
    		177,244,000 115,745,000 111,208,000 60,046,000 126,404,000 119,487,000 72,474,000 98,417,000 83,256,000 72,425,000 106,876,000 67,893,000 24,963,000 43,901,000 82,253,000 59,731,000 10,000,000 57,913,000 144,169,000 209,444,000 278,521,000 128,942,000 97,870,000 186,452,000 189,936,000 204,637,000 243,904,000 235,328,000 268,200,000 73,672,000 
      accounts receivable
    		51,742,000 31,910,000 40,065,000 41,724,000 24,888,000 20,451,000 15,995,000 21,266,000 3,041,000 24,650,000 7,424,000 12,660,000 11,159,000 7,808,000 29,440,000 3,985,000 3,224,000 2,551,000             
      inventory
    		41,396,000 48,181,000 22,069,000 26,364,000 28,680,000 34,858,000 27,278,000 31,122,000 25,583,000 23,958,000 23,425,000 21,599,000 14,621,000 19,916,000 13,223,000 3,675,000 5,606,000 6,381,000 2,189,000            
      prepaid expenses and other current assets
    		30,290,000 32,438,000 25,433,000 20,084,000 33,953,000 26,954,000 13,766,000 17,538,000 26,401,000 12,440,000 13,157,000 10,537,000 15,311,000 14,006,000 10,517,000 6,585,000 8,499,000 9,802,000 9,140,000 9,557,000 14,018,000 12,095,000 8,849,000 8,247,000 9,595,000 9,011,000 8,423,000 6,446,000 3,665,000 4,416,000 
      total current assets
    		475,530,000 420,311,000 355,907,000 331,799,000 311,301,000 301,021,000 270,591,000 276,297,000 256,109,000 246,040,000 231,500,000 243,060,000 241,815,000 179,938,000 198,757,000 196,446,000 217,512,000 244,810,000 275,564,000 333,249,000 378,413,000 264,493,000 213,055,000 241,627,000 268,340,000 296,458,000 334,956,000 313,750,000 341,528,000 363,869,000 
      property and equipment
    		1,655,000 1,076,000 606,000 662,000 561,000 625,000 712,000 734,000 918,000 1,136,000 1,393,000 1,658,000 1,995,000 2,150,000 2,475,000 2,834,000 3,168,000 3,449,000 3,815,000 4,051,000 4,573,000 5,210,000 5,804,000 6,398,000 6,409,000 6,359,000 6,190,000 6,356,000 2,360,000 350,000 
      operating lease right-of-use assets
    		10,073,000 10,304,000 10,453,000 10,376,000 11,095,000 11,779,000 12,324,000 11,931,000 12,668,000 13,191,000 5,228,000 5,385,000 6,173,000 4,069,000 4,815,000 5,550,000 6,128,000 5,386,000 5,982,000 6,566,000 1,166,000 1,323,000 1,629,000 1,927,000 2,218,000 2,503,000 3,347,000    
      other long-term assets
    		8,288,000 8,195,000 8,202,000 10,315,000 7,853,000 7,904,000 4,128,000 827,000 2,294,000 2,353,000 2,323,000 5,824,000 5,627,000 5,669,000 5,918,000 8,720,000 6,551,000 5,813,000 5,797,000 5,588,000 48,000          
      intangible asset
    		15,500,000 15,750,000 16,000,000 16,250,000 16,500,000 16,750,000 17,000,000 17,250,000 17,500,000 17,750,000 18,000,000 18,250,000 18,500,000 18,750,000 19,000,000 19,250,000 19,500,000 19,750,000 20,000,000            
      deferred tax assets
    		201,287,000 205,514,000 208,158,000 211,151,000 207,988,000 204,349,000 214,918,000 219,283,000 193,574,000 203,862,000 184,418,000 185,495,000 185,843,000       10,000 3,000  5,410,000 4,372,000 4,628,000 2,607,000 1,456,000 1,216,000 1,173,000 700,000 
      total assets
    		712,333,000 661,150,000 599,326,000 580,553,000 555,298,000 542,428,000 519,673,000 526,322,000 483,063,000 484,332,000 442,862,000 459,672,000 459,953,000 210,576,000 230,965,000 232,800,000 252,859,000 279,208,000 311,158,000 349,464,000 384,413,000 271,441,000 226,108,000 254,534,000 281,805,000 308,137,000 346,159,000 321,965,000 347,101,000 365,129,000 
      ​
    		                              
      liabilities and shareholders’ equity
    		                              
      current liabilities:
    		                              
      accounts payable
    		6,150,000 8,956,000 1,982,000 2,039,000 8,328,000 7,393,000 5,632,000 8,246,000 1,012,000 648,000 1,391,000 7,899,000 1,469,000 2,522,000 3,383,000 1,868,000 1,649,000 4,156,000 2,763,000 503,000 3,925,000 2,373,000 4,274,000 5,693,000 6,440,000 9,338,000 6,890,000 10,918,000 4,668,000 561,000 
      accrued collaboration expenses
    		63,282,000 52,389,000 53,775,000 48,157,000 29,148,000 29,943,000                         
      accrued expenses
    		30,941,000 35,959,000 22,126,000 32,355,000 40,379,000 33,374,000 44,718,000 44,667,000 41,149,000 35,316,000 20,885,000 30,112,000 30,868,000 34,500,000 38,887,000 38,031,000 28,528,000 31,064,000 30,316,000 29,199,000 19,475,000 16,499,000 13,379,000 20,415,000 19,360,000 19,179,000 15,618,000 16,418,000 13,353,000 12,583,000 
      operating lease liabilities
    		2,696,000 2,522,000 2,292,000 1,993,000 2,031,000 2,085,000 2,279,000 2,253,000 2,313,000 2,238,000 3,482,000 3,301,000 3,274,000 3,336,000 3,311,000 3,381,000 3,246,000 2,636,000 2,374,000 2,107,000 1,492,000 1,680,000 1,689,000 1,697,000 1,610,000 1,496,000 1,384,000    
      other current liabilities
    		20,523,000 18,001,000 17,092,000 16,077,000 16,069,000 11,484,000 11,427,000 8,193,000 6,430,000 4,596,000 4,334,000 5,754,000 8,789,000 3,186,000 4,773,000 1,544,000 1,004,000 926,000  37,000    25,000  165,000  218,000   
      total current liabilities
    		123,592,000 117,827,000 97,267,000 100,621,000 95,955,000 84,291,000 64,212,000 63,666,000 53,468,000 47,472,000 36,587,000 47,066,000 56,492,000 43,544,000 50,354,000 44,824,000 34,427,000 38,782,000 35,453,000 31,846,000 24,892,000 20,552,000 19,342,000 27,830,000 27,560,000 30,178,000 36,892,000 42,554,000 28,021,000 23,144,000 
      non-current liabilities:
    		                              
      non-current deferred revenue
    		31,811,000 31,811,000 31,811,000 31,811,000 11,811,000 11,799,000 11,811,000 11,954,000 11,872,000 12,006,000 12,163,000 12,000,000 14,198,000                  
      non-current operating lease liabilities
    		7,022,000 7,243,000 7,623,000 7,862,000 8,564,000 9,317,000 9,864,000 10,005,000 10,651,000 11,283,000 2,133,000 2,618,000 3,435,000 1,278,000 2,096,000 2,669,000 3,499,000 3,500,000 4,200,000 4,878,000 55,000 139,000 551,000        
      other long-term liabilities
    		14,525,000 9,262,000 5,136,000 1,823,000 1,962,000 1,926,000 1,891,000 1,858,000 1,945,000 1,915,000 1,884,000 1,839,000 1,820,000 260,000 271,000 270,000 885,000 1,141,000 809,000 805,000 957,000 334,000 381,000 326,000 943,000 943,000 509,000    
      total liabilities
    		176,950,000 166,143,000 141,837,000 142,117,000 118,292,000 107,333,000 87,778,000 87,483,000 77,936,000 72,676,000 52,767,000 63,523,000 75,945,000 57,082,000 64,721,000 47,763,000 38,811,000 43,423,000 40,462,000 37,529,000 25,904,000 21,025,000 20,274,000 29,111,000 29,894,000 32,940,000 39,640,000 42,698,000 28,188,000 23,330,000 
      commitments and contingencies
    		                              
      shareholders’ equity:
    		                              
      class a ordinary shares, nominal value of 0.000273235 per share; 44,789,913 shares and 41,881,319 shares issued and outstanding as of september 30, 2025 and december 31, 2024, respectively
    		12,000                              
      class b ordinary shares, nominal value of 0.000273235 per share; 1,795,158 shares issued and outstanding as of september 30, 2025 and december 31, 2024
    		1,000                              
      class a1 ordinary shares, nominal value of 0.000273235 per share; 12,781,964 shares issued and outstanding as of september 30, 2025 and december 31, 2024
    		4,000                              
      class b1 ordinary shares, 0.000273235 nominal value; 16,057,618 shares issued and outstanding as of september 30, 2025 and december 31, 2024
    		4,000                              
      additional paid-in capital
    		1,011,854,000 989,811,000 970,238,000 959,722,000 949,282,000 934,767,000 927,582,000 916,763,000 908,295,000 900,956,000 894,325,000 888,120,000 880,554,000 874,153,000 866,935,000 860,482,000 853,139,000 844,260,000 837,656,000 829,424,000 822,301,000 670,371,000 588,090,000 581,467,000 576,129,000 572,318,000 566,542,000 473,483,000 470,600,000 469,018,000 
      accumulated other comprehensive loss
    		-155,000 -53,000 -165,000          -70,000 -90,000 -103,000 -66,000   -21,000            
      accumulated deficit
    		-476,337,000 -494,772,000 -512,604,000 -521,143,000 -512,255,000 -499,562,000 -495,654,000 -477,950,000 -503,187,000 -489,332,000 -504,304,000 -492,034,000 -496,495,000 -720,588,000 -700,607,000 -675,397,000 -639,064,000 -608,520,000 -566,957,000 -517,473,000 -463,816,000 -419,980,000 -382,511,000 -356,092,000 -324,295,000 -297,237,000 -260,046,000 -194,225,000 -151,645,000  
      total shareholders’ equity
    		535,383,000 495,007,000 457,489,000 438,436,000 437,006,000 435,095,000 431,895,000 438,839,000 405,127,000 411,656,000 390,095,000 396,149,000 384,008,000 153,494,000 166,244,000 185,037,000 214,048,000 235,785,000 270,696,000 311,935,000 358,509,000 250,416,000 205,834,000 225,423,000 251,911,000 275,197,000 306,519,000 279,267,000 318,913,000 341,799,000 
      total liabilities and shareholders’ equity
    		712,333,000 661,150,000 599,326,000 580,553,000 555,298,000 542,428,000 519,673,000 526,322,000 483,063,000 484,332,000 442,862,000 459,672,000 459,953,000 210,576,000 230,965,000 232,800,000 252,859,000 279,208,000 311,158,000 349,464,000 384,413,000 271,441,000 226,108,000 254,534,000 281,805,000 308,137,000 346,159,000    
      class a ordinary shares, nominal value of 0.000273235 per share; 43,397,623 shares and 41,881,319 shares issued and outstanding as of june 30, 2025 and december 31, 2024, respectively
    		 12,000                             
      class b ordinary shares, nominal value of 0.000273235 per share; 1,795,158 shares issued and outstanding as of june 30, 2025 and december 31, 2024
    		 1,000                             
      class a1 ordinary shares, nominal value of 0.000273235 per share; 12,781,964 shares issued and outstanding as of june 30, 2025 and december 31, 2024
    		 4,000                             
      class b1 ordinary shares, 0.000273235 nominal value; 16,057,618 shares issued and outstanding as of june 30, 2025 and december 31, 2024
    		 4,000                             
      class a ordinary shares, nominal value of 0.000273235 per share; 42,162,592 shares and 41,881,319 shares issued and outstanding as of march 31, 2025 and december 31, 2024, respectively
    		  11,000                            
      class b ordinary shares, nominal value of 0.000273235 per share; 1,795,158 shares issued and outstanding as of march 31, 2025 and december 31, 2024
    		  1,000                            
      class a1 ordinary shares, nominal value of 0.000273235 per share; 12,781,964 shares issued and outstanding as of march 31, 2025 and december 31, 2024
    		  4,000                            
      class b1 ordinary shares, 0.000273235 nominal value; 16,057,618 shares issued and outstanding as of march 31, 2025 and december 31, 2024
    		  4,000                            
      deferred revenue
    		     12,000 156,000 307,000 2,564,000 4,674,000 6,495,000  12,092,000 12,000,000 12,000,000                
      class a ordinary shares, par value of 0.000273235 per share; 41,881,319 shares and 35,781,373 shares issued and outstanding as of december 31, 2024 and 2023, respectively
    		   11,000                           
      class b ordinary shares, par value of 0.000273235 per share; 1,795,158 shares issued and outstanding as of december 31, 2024 and 2023
    		   1,000                           
      class a1 ordinary shares, 0.000273235 par value; 12,781,964 shares and 16,826,468 issued and outstanding as of december 31, 2024 and 2023, respectively
    		   4,000                           
      class b1 ordinary shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of december 31, 2024 and 2023
    		   4,000                           
      accumulated other comprehensive income
    		   -163,000 -41,000 -130,000 -53,000 6,000 -1,000 13,000 55,000 44,000     -45,000 27,000  -34,000 6,000 9,000 240,000 33,000 62,000 101,000 8,000  -55,000 7,000 
      class a ordinary shares, nominal value of 0.000273235 per share; 41,523,449 shares and 35,781,373 shares issued and outstanding as of september 30, 2024 and december 31, 2023, respectively
    		    11,000                          
      class b ordinary shares, nominal value of 0.000273235 per share; 1,795,158 shares issued and outstanding as of september 30, 2024 and december 31, 2023
    		    1,000                          
      class a1 ordinary shares, 0.000273235 nominal value; 12,781,964 and 16,826,468 shares issued and outstanding as of september 30, 2024 and december 31, 2023, respectively
    		    4,000                          
      class b1 ordinary shares, 0.000273235 nominal value; 16,057,618 shares issued and outstanding as of september 30, 2024 and december 31, 2023
    		    4,000                          
      class a ordinary shares, nominal value of 0.000273235 per share; 40,447,538 shares and 35,781,373 shares issued and outstanding as of june 30, 2024 and december 31, 2023, respectively
    		     11,000                         
      class b ordinary shares, nominal value of 0.000273235 per share; 1,795,158 shares issued and outstanding as of june 30, 2024 and december 31, 2023
    		     1,000                         
      class a1 ordinary shares, 0.000273235 nominal value; 12,781,964 and 16,826,468 shares issued and outstanding as of june 30, 2024 and december 31, 2023, respectively
    		     4,000                         
      class b1 ordinary shares, 0.000273235 nominal value; 16,057,618 shares issued and outstanding as of june 30, 2024 and december 31, 2023
    		     4,000                         
      class a common shares, par value of 0.000273235 per share; 40,184,356 shares and 35,781,373 shares issued and outstanding as of march 31, 2024 and december 31, 2023, respectively
    		      11,000                        
      class b common shares, par value of 0.000273235 per share; 1,795,158 shares issued and outstanding as of march 31, 2024 and december 31, 2023
    		      1,000                        
      class a1 common shares, 0.000273235 par value; 12,781,964 and 16,826,468 shares issued and outstanding as of march 31, 2024 and december 31, 2023, respectively
    		      4,000                        
      class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of march 31, 2024 and december 31, 2023
    		      4,000                        
      contract asset
    		           7,656,000                   
      class a common shares, par value of 0.000273235 per share; 35,781,373 shares and 34,750,560 shares issued and outstanding as of december 31, 2023 and 2022, respectively
    		       10,000                       
      class b common shares, par value of 0.000273235 per share; 1,795,158 shares and 1,813,457 shares issued and outstanding as of december 31, 2023 and 2022, respectively
    		       1,000                       
      class a1 common shares, 0.000273235 par value; 16,826,468 shares and 17,075,868 issued and outstanding as of december 31, 2023 and 2022, respectively
    		       5,000                       
      class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of december 31, 2023 and 2022
    		       4,000                       
      class a common shares, par value of 0.000273235 per share; 35,387,987 shares and 34,750,560 shares issued and outstanding as of september 30, 2023 and december 31, 2022, respectively
    		        10,000                      
      class b common shares, par value of 0.000273235 per share; 1,795,158 shares and 1,813,457 shares issued and outstanding as of september 30, 2023 and december 31, 2022, respectively
    		        1,000                      
      class a1 common shares, 0.000273235 par value; 17,075,868 shares issued and outstanding as of september 30, 2023 and december 31, 2022
    		        5,000                      
      class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of september 30, 2023 and december 31, 2022
    		        4,000                      
      class a common shares, par value of 0.000273235 per share; 35,074,019 shares and 34,750,560 shares issued and outstanding as of june 30, 2023 and december 31, 2022, respectively
    		         9,000                     
      class b common shares, par value of 0.000273235 per share; 1,795,158 shares and 1,813,457 shares issued and outstanding as of june 30, 2023 and december 31, 2022, respectively
    		         1,000                     
      class a1 common shares, 0.000273235 par value; 17,075,868 shares issued and outstanding as of june 30, 2023 and december 31, 2022
    		         5,000                     
      class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of june 30, 2023 and december 31, 2022
    		         4,000                     
      class a common shares, par value of 0.000273235 per share; 34,886,136 shares and 34,750,560 shares issued and outstanding as of march 31, 2023 and december 31, 2022, respectively
    		          9,000                    
      class b common shares, par value of 0.000273235 per share; 1,813,457 shares issued and outstanding as of march 31, 2023 and december 31, 2022
    		          1,000                    
      class a1 common shares, 0.000273235 par value; 17,075,868 shares issued and outstanding as of march 31, 2023 and december 31, 2022
    		          5,000                    
      class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of march 31, 2023 and december 31, 2022
    		          4,000                    
      class a common shares, par value of 0.000273235 per share; 34,750,560 shares and 34,059,725 shares issued and outstanding as of december 31, 2022 and 2021, respectively
    		           9,000                   
      class b common shares, par value of 0.000273235 per share; 1,813,457 shares issued and outstanding as of december 31, 2022 and 2021
    		           1,000                   
      class a1 common shares, 0.000273235 par value; 17,075,868 shares and 17,129,603 issued and outstanding as of december 31, 2022 and 2021, respectively
    		           5,000                   
      class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of december 31, 2022 and 2021
    		           4,000                   
      class a common shares, par value of 0.000273235 per share; 34,523,660 shares and 34,059,725 shares issued and outstanding as of september 30, 2022 and december 31, 2021, respectively
    		            9,000                  
      class b common shares, par value of 0.000273235 per share; 1,813,457 shares issued and outstanding as of september 30, 2022 and december 31, 2021
    		            1,000                  
      class a1 common shares, 0.000273235 par value; 17,129,603 shares issued and outstanding as of september 30, 2022 and december 31, 2021
    		            5,000                  
      class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of september 30, 2022 and december 31, 2021
    		            4,000                  
      class a common shares, par value of 0.000273235 per share; 34,426,089 shares and 34,059,725 shares issued and outstanding as of june 30, 2022 and december 31, 2021, respectively
    		             9,000                 
      class b common shares, par value of 0.000273235 per share; 1,813,457 shares issued and outstanding as of june 30, 2022 and december 31, 2021
    		             1,000                 
      class a1 common shares, 0.000273235 par value; 17,129,603 shares issued and outstanding as of june 30, 2022 and december 31, 2021
    		             5,000                 
      class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of june 30, 2022 and december 31, 2021
    		             4,000                 
      class a common shares, par value of 0.000273235 per share; 34,270,445 shares and 34,059,725 shares issued and outstanding as of march 31, 2022 and december 31, 2021, respectively
    		              9,000                
      class b common shares, par value of 0.000273235 per share; 1,813,457 shares issued and outstanding as of march 31, 2022 and december 31, 2021
    		              1,000                
      class a1 common shares, 0.000273235 par value; 17,129,603 shares issued and outstanding as of march 31, 2022 and december 31, 2021
    		              5,000                
      class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of march 31, 2022 and december 31, 2021
    		              4,000                
      restricted cash
    		                 210,000 210,000 210,000 210,000 210,000 210,000 210,000 210,000 210,000 210,000   263,000 
      class a common shares, par value of 0.000273235 per share; 34,059,725 shares and 31,777,420 shares issued and outstanding as of december 31, 2021 and 2020, respectively
    		               8,000               
      class b common shares, par value of 0.000273235 per share; 1,813,457 shares and 2,355,458 shares issued and outstanding as of december 31, 2021 and 2020, respectively
    		               1,000               
      class a1 common shares, 0.000273235 par value; 17,129,603 shares and 18,024,526 issued and outstanding as of december 31, 2021 and 2020, respectively
    		               5,000               
      class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of december 31, 2021 and 2020
    		               4,000               
      class a common shares, par value of 0.000273235 per share; 32,992,834 shares and 31,777,420 shares issued and outstanding as of september 30, 2021 and december 31, 2020, respectively
    		                8,000              
      class b common shares, par value of 0.000273235 per share; 1,813,457 shares and 2,355,458 shares issued and outstanding as of september 30, 2021 and december 31, 2020, respectively
    		                1,000              
      class a1 common shares, 0.000273235 par value; 18,024,526 issued and outstanding as of september 30, 2021 and december 31, 2020
    		                5,000              
      class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of september 30, 2021 and december 31, 2020
    		                4,000              
      class a common shares, par value of 0.000273235 per share; 32,569,148 shares and 31,777,420 shares issued and outstanding as of june 30, 2021 and december 31, 2020, respectively
    		                 8,000             
      class b common shares, par value of 0.000273235 per share; 1,813,457 shares and 2,355,458 shares issued and outstanding as of june 30, 2021 and december 31, 2020, respectively
    		                 1,000             
      class a1 common shares, 0.000273235 par value; 18,024,526 issued and outstanding as of june 30, 2021 and december 31, 2020
    		                 5,000             
      class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of june 30, 2021 and december 31, 2020
    		                 4,000             
      class a common shares, par value of 0.000273235 per share; 32,320,276 shares and 31,777,420 shares issued and outstanding as of march 31, 2021 and december 31, 2020, respectively
    		                  8,000            
      class b common shares, par value of 0.000273235 per share; 1,927,614 shares and 2,355,458 shares issued and outstanding as of march 31, 2021 and december 31, 2020, respectively
    		                  1,000            
      class a1 common shares, 0.000273235 par value; 18,024,526 issued and outstanding as of march 31, 2021 and december 31, 2020
    		                  5,000            
      class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of march 31, 2021 and december 31, 2020
    		                  4,000            
      non-current restricted cash
    		                              
      class a common shares, par value of 0.000273235 per share; 31,777,420 shares and 19,245,201 shares issued and outstanding as of december 31, 2020 and 2019, respectively
    		                   8,000           
      class b common shares, par value of 0.000273235 per share; 2,355,458 shares and 4,638,855 shares issued and outstanding as of december 31, 2020 and 2019, respectively
    		                   1,000           
      class a1 common shares, 0.000273235 par value; 18,024,526 shares and 14,995,954 issued and outstanding as of december 31, 2020 and 2019, respectively
    		                   5,000           
      class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of december 31, 2020 and 2019
    		                   4,000           
      class a common shares, par value of 0.000273235 per share; 31,479,648 shares and 19,245,201 shares issued and outstanding as of september 30, 2020 and december 31, 2019, respectively
    		                    8,000          
      class b common shares, par value of 0.000273235 per share; 2,355,458 shares and 4,638,855 shares issued and outstanding as of september 30, 2020 and december 31, 2019, respectively
    		                    1,000          
      class a1 common shares, 0.000273235 par value; 18,024,526 shares and 14,995,954 issued and outstanding as of september 30, 2020 and december 31, 2019, respectively
    		                    5,000          
      class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of september 30, 2020 and december 31, 2019
    		                    4,000          
      deferred offering costs
    		                     205,000      433,000   
      class a common shares, par value of 0.000273235 per share; 25,369,973 shares and 19,245,201 shares issued and outstanding as of june 30, 2020 and december 31, 2019, respectively
    		                     7,000         
      class b common shares, par value of 0.000273235 per share; 2,463,011 shares and 4,638,855 shares issued and outstanding as of june 30, 2020 and december 31, 2019
    		                     1,000         
      class a1 common shares, 0.000273235 par value; 16,595,954 shares and 14,995,954 issued and outstanding as of june 30, 2020 and december 31, 2019, respectively
    		                     4,000         
      class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of june 30, 2020 and december 31, 2019
    		                     4,000         
      class a common shares, par value of 0.000273235 per share; 21,519,500 shares and 19,245,201 shares issued and outstanding as of march 31, 2020 and december 31, 2019, respectively
    		                      6,000        
      class b common shares, par value of 0.000273235 per share; 3,008,373 shares and 4,638,855 shares issued and outstanding as of march 31, 2020 and december 31, 2019
    		                      1,000        
      class a1 common shares, 0.000273235 par value; 14,995,954 shares issued and outstanding as of march 31, 2020 and december 31, 2019, respectively
    		                      4,000        
      class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of march 31, 2020 and december 31, 2019
    		                      4,000        
      accrued milestones
    		                        150,000  13,000,000 15,000,000   
      noncurrent liabilities:
    		                              
      noncurrent operating lease liabilities
    		                       955,000 1,391,000 1,819,000 2,239,000    
      class a common shares, par value of 0.000273235 per share; 19,245,201 shares and 15,797,220 shares issued and outstanding as of december 31, 2019 and december 31, 2018, respectively
    		                       6,000       
      class b common shares, par value of 0.000273235 per share; 4,638,855 shares issued and outstanding as of december 31, 2019 and december 31, 2018
    		                       1,000       
      class a1 common shares, 0.000273235 par value; 14,995,954 and 12,995,954 shares issued and outstanding as of december 31, 2019 and december 31, 2018, respectively
    		                       4,000       
      class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of december 31, 2019 and december 31, 2018
    		                       4,000       
      class a common shares, par value of 0.000273235 per share; 19,178,913 shares and 15,797,220 shares issued and outstanding as of september 30, 2019 and december 31, 2018, respectively
    		                        6,000      
      class b common shares, par value of 0.000273235 per share; 4,638,855 shares issued and outstanding as of september 30, 2019 and december 31, 2018
    		                        1,000      
      class a1 common shares, 0.000273235 par value; 14,995,954 shares and 12,995,954 shares issued and outstanding as of september 30, 2019 and december 31, 2018, respectively
    		                        4,000      
      class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of september 30, 2019 and december 31, 2018
    		                        4,000      
      class a common shares, par value of 0.000273235 per share; 19,165,265 shares and 15,797,220 shares issued and outstanding as of june 30, 2019 and december 31, 2018, respectively
    		                         6,000     
      class b common shares, par value of 0.000273235 per share; 4,638,855 shares issued and outstanding as of june 30, 2019 and december 31, 2018
    		                         1,000     
      class a1 common shares, 0.000273235 par value; 14,995,954 shares and 12,995,954 shares issued and outstanding as of june 30, 2019 and december 31, 2018, respectively
    		                         4,000     
      class b1 common shares, 0.000273235 par value; 16,057,618 shares issued and outstanding as of june 30, 2019 and december 31, 2018
    		                         4,000     
      class a common shares, par value of 0.000273235 per share; 19,000,408 shares and 15,797,220 shares issued and outstanding as of march 31, 2019 and december 31, 2018, respectively
    		                          6,000    
      class b common shares, par value of 0.000273235 per share; 4,638,855 shares and 4,638,855 shares issued and outstanding as of march 31, 2019 and december 31, 2018, respectively
    		                          1,000    
      class a1 common shares, 0.000273235 par value; 14,995,954 shares and 12,995,954 shares issued and outstanding as of march 31, 2019 and december 31, 2018, respectively
    		                          4,000    
      class b1 common shares, 0.000273235 par value; 16,057,618 shares and 16,057,618 shares issued and outstanding as of march 31, 2019 and december 31, 2018, respectively
    		                          4,000    
      liabilities, convertible preferred shares and shareholders’ equity
    		                              
      deferred rent
    		                           144,000 167,000 186,000 
      convertible preferred shares (series a, b and c), 0.000273235 par value; 0 shares and 22,885,492 shares issued and outstanding as of december 31, 2018 and december 31, 2017, respectively; aggregate liquidation preference of 0 and 120,000 as of december 31, 2018 and december 31, 2017, respectively;
    		                              
      shareholders’ equity
    		                              
      class a common shares, par value of 0.000273235 per share; 15,797,220 shares and 719,976 shares issued and outstanding as of december 31, 2018 and december 31, 2017; respectively
    		                           4,000   
      class b common shares, par value of 0.000273235 per share; 4,638,855 shares and 3,568,353 shares issued and outstanding as of december 31, 2018 and december 31, 2017, respectively
    		                           1,000   
      class a1 common shares, 0.000273235 par value; 12,995,954 shares and 0 shares issued and outstanding as of december 31, 2018 and december 31, 2017, respectively
    		                           4,000   
      class b1 common shares, 0.000273235 par value; 16,057,618 shares and 0 shares issued and outstanding as of december 31, 2018 and december 31, 2017, respectively
    		                           4,000   
      total liabilities, convertible preferred shares and shareholders’ equity
    		                           321,965,000 347,101,000 365,129,000 
      advanced clinical payments
    		                            1,830,000  
      accrued milestone
    		                            10,000,000 10,000,000 
      convertible preferred shares (series a, b and c), 0.000273235 par value; 0 shares and 22,885,492 shares issued and outstanding as of september 30, 2018 and december 31, 2017, respectively; aggregate liquidation preference of 0 and 120,000 as of september 30, 2018 and december 31, 2017, respectively;
    		                              
      class a common shares, par value of 0.000273235 per share; 15,772,257 shares and 719,976 shares issued and outstanding as of september 30, 2018 and december 31, 2017; respectively
    		                            4,000  
      class b common shares, par value of 0.000273235 per share; 4,638,855 shares and 3,568,353 shares issued and outstanding as of september 30, 2018 and december 31, 2017, respectively
    		                            1,000  
      class a1 common shares, 0.000273235 par value; 12,995,954 shares and 0 shares issued and outstanding as of september 30, 2018 and december 31, 2017, respectively
    		                            4,000  
      class b1 common shares, 0.000273235 par value; 16,057,618 shares and 0 shares issued and outstanding as of september 30, 2018 and december 31, 2017, respectively
    		                            4,000  
      convertible preferred shares (series a, b and c), 0.000273235 par value; 0 shares and 22,885,492 shares issued and outstanding as of june 30, 2018 and december 31, 2017, respectively; aggregate liquidation preference of 0 and 120,000 as of june 30, 2018 and december 31, 2017, respectively;
    		                              
      class a common shares, par value of 0.000273235 per share; 15,754,771 shares and 719,976 shares issued and outstanding as of june 30, 2018 and december 31, 2017; respectively
    		                             4,000 
      class b common shares, par value of 0.000273235 per share; 4,638,855 shares and 3,568,353 shares issued and outstanding as of june 30, 2018 and december 31, 2017, respectively
    		                             1,000 
      class a1 common shares, 0.000273235 par value; 12,995,954 shares and 0 shares issued and outstanding as of june 30, 2018 and december 31, 2017, respectively
    		                             4,000 
      class b1 common shares, 0.000273235 par value; 16,057,618 shares and 0 shares issued and outstanding as of june 30, 2018 and december 31, 2017, respectively
    		                             4,000 
    The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.