Jazz Pharmaceuticals plc(NASDAQ:JAZZ) 
Jazz Pharmaceuticals plc, a biopharmaceutical company, identifies, develops and commercializes pharmaceutical products for various unmet medical needs in the United States, Europe, and internationally. The company has a portfolio of products and product candidates with a focus in the areas of neuros...
Website: http://www.jazzpharma.com
Founded: 2005
Full Time Employees: 1,620
Sector: Healthcare
Industry: Biotechnology
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| Unit: USD | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-12-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-12-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-12-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 | 2013-12-31 | 2013-09-30 | 2013-06-30 | 2013-03-31 | 2012-12-31 | 2012-09-30 | 2012-06-30 | 2012-03-31 | 2011-12-31 | 2011-09-30 | 2011-06-30 | 2011-03-31 | 2010-12-31 | 2010-09-30 | 2010-06-30 | 2010-03-31 | 2009-12-31 | 2009-09-30 | 2009-06-30 | 2009-03-31 | 2008-12-31 | 2008-09-30 | 2008-06-30 | 2008-03-31 | 2007-12-31 | 2007-09-30 | 2007-06-30 |
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revenues: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
product sales | 1,132,448,000 | 1,064,412,000 | 985,571,000 | 839,418,000 | 1,025,211,000 | 989,707,000 | 964,144,000 | 842,102,000 | 967,339,000 | 938,398,000 | 946,987,000 | 884,219,000 | 967,526,000 | 935,766,000 | 928,300,000 | 809,837,000 | 892,883,000 | 834,247,000 | 748,340,000 | 603,531,000 | 661,303,000 | 596,949,000 | 558,203,000 | 530,205,000 | 576,526,000 | 532,321,000 | 523,423,000 | 503,331,000 | 467,334,000 | 465,197,000 | 496,095,000 | 440,847,000 | 430,095,000 | 407,971,000 | 389,655,000 | 373,678,000 | 392,614,000 | 371,621,000 | 379,110,000 | 333,916,000 | 338,924,000 | 338,754,000 | 332,106,000 | 307,035,000 | 324,223,000 | 304,407,000 | 289,100,000 | 244,986,000 | 233,796,000 | 230,386,000 | 206,564,000 | 194,652,000 | 181,942,000 | 174,130,000 | 128,310,000 | 107,336,000 | 80,935,000 | 72,216,000 | 63,464,000 | 49,903,000 | 52,357,000 | 43,838,000 | 39,528,000 | 34,283,000 | 37,319,000 | 29,992,000 | 26,478,000 | 21,319,000 | 18,880,000 | 17,022,000 | 14,751,000 | 13,984,000 | 14,860,000 | 13,436,000 | 13,615,000 |
royalties and contract revenues | 65,478,000 | 61,695,000 | 60,141,000 | 58,423,000 | 62,962,000 | 65,262,000 | 59,681,000 | 59,881,000 | 44,596,000 | 33,742,000 | 10,330,000 | 8,593,000 | 4,597,000 | 4,886,000 | 4,578,000 | 3,884,000 | 3,848,000 | 3,868,000 | 3,471,000 | 4,050,000 | 4,214,000 | 3,939,000 | 4,233,000 | 4,521,000 | 5,214,000 | 5,381,000 | 10,710,000 | 4,855,000 | 9,123,000 | 4,176,000 | 4,384,000 | 3,766,000 | 6,304,000 | 3,884,000 | 4,731,000 | 2,375,000 | 4,007,000 | 2,560,000 | 2,051,000 | 2,094,000 | 1,957,000 | 2,118,000 | 1,641,000 | 2,268,000 | 3,919,000 | 2,177,000 | 2,130,000 | 1,933,000 | 1,978,000 | 1,774,000 | 1,688,000 | 1,585,000 | 1,761,000 | 1,385,000 | 1,229,000 | 1,078,000 | |||||||||||||||||||
total revenues | 1,197,926,000 | 1,126,107,000 | 1,045,712,000 | 897,841,000 | 1,088,173,000 | 1,054,969,000 | 1,023,825,000 | 901,983,000 | 1,011,935,000 | 972,140,000 | 957,317,000 | 892,812,000 | 972,123,000 | 940,652,000 | 932,878,000 | 813,721,000 | 896,731,000 | 838,115,000 | 751,811,000 | 607,581,000 | 665,517,000 | 600,888,000 | 562,436,000 | 534,726,000 | 581,740,000 | 537,702,000 | 534,133,000 | 508,186,000 | 476,457,000 | 469,373,000 | 500,479,000 | 444,613,000 | 436,399,000 | 411,855,000 | 394,386,000 | 376,053,000 | 396,621,000 | 374,181,000 | 381,161,000 | 336,010,000 | 340,881,000 | 340,872,000 | 333,747,000 | 309,303,000 | 328,142,000 | 306,584,000 | 291,230,000 | 246,919,000 | 235,774,000 | 232,160,000 | 208,252,000 | 196,237,000 | 183,703,000 | 175,515,000 | 129,539,000 | 108,414,000 | 83,536,000 | 73,293,000 | 64,567,000 | 50,881,000 | 53,369,000 | 44,753,000 | 40,486,000 | 35,173,000 | 38,284,000 | 30,809,000 | 37,280,000 | 22,076,000 | 19,595,000 | 17,746,000 | 15,539,000 | 14,634,000 | 15,477,000 | 21,474,000 | 14,264,000 |
yoy | 10.09% | 6.74% | 2.14% | -0.46% | 7.53% | 8.52% | 6.95% | 1.03% | 4.10% | 3.35% | 2.62% | 9.72% | 8.41% | 12.23% | 24.08% | 33.93% | 34.74% | 39.48% | 33.67% | 13.62% | 14.40% | 11.75% | 5.30% | 5.22% | 22.10% | 14.56% | 6.72% | 14.30% | 9.18% | 13.97% | 26.90% | 18.23% | 10.03% | 10.07% | 3.47% | 11.92% | 16.35% | 9.77% | 14.21% | 8.63% | 3.88% | 11.18% | 14.60% | 25.26% | 39.18% | 32.06% | 39.84% | 25.83% | 28.35% | 32.27% | 60.76% | 81.01% | 119.91% | 139.47% | 100.63% | 113.07% | 56.53% | 63.77% | 59.48% | 44.66% | 39.40% | 45.26% | 8.60% | 59.33% | 95.38% | 73.61% | 139.91% | 50.85% | 26.61% | -17.36% | 8.94% | ||||
qoq | 6.38% | 7.69% | 16.47% | -17.49% | 3.15% | 3.04% | 13.51% | -10.87% | 4.09% | 1.55% | 7.22% | -8.16% | 3.35% | 0.83% | 14.64% | -9.26% | 6.99% | 11.48% | 23.74% | -8.71% | 10.76% | 6.84% | 5.18% | -8.08% | 8.19% | 0.67% | 5.11% | 6.66% | 1.51% | -6.22% | 12.57% | 1.88% | 5.96% | 4.43% | 4.88% | -5.19% | 6.00% | -1.83% | 13.44% | -1.43% | 0.00% | 2.13% | 7.90% | -5.74% | 7.03% | 5.27% | 17.95% | 4.73% | 1.56% | 11.48% | 6.12% | 6.82% | 4.67% | 35.49% | 19.49% | 29.78% | 13.98% | 13.51% | 26.90% | -4.66% | 19.25% | 10.54% | 15.11% | -8.13% | 24.26% | -17.36% | 68.87% | 12.66% | 10.42% | 14.20% | 6.18% | -5.45% | -27.93% | 50.55% | |
operating expenses: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cost of product sales | 153,528,000 | 128,880,000 | 116,268,000 | 104,620,000 | 128,713,000 | 111,611,000 | 109,902,000 | 95,487,000 | 107,243,000 | 102,153,000 | 97,537,000 | 128,644,000 | 167,364,000 | 133,661,000 | 124,208,000 | 115,284,000 | 136,153,000 | 145,224,000 | 119,194,000 | 40,189,000 | 50,157,000 | 42,095,000 | 28,008,000 | 28,657,000 | 35,348,000 | 31,400,000 | 27,676,000 | 33,506,000 | 26,337,000 | 26,574,000 | 34,714,000 | 33,919,000 | 25,248,000 | 31,203,000 | 28,672,000 | 25,065,000 | 33,656,000 | 24,311,000 | 23,980,000 | 23,439,000 | 24,030,000 | 28,385,000 | 21,813,000 | 28,298,000 | 28,808,000 | 26,994,000 | 30,692,000 | 30,924,000 | 25,643,000 | 24,252,000 | 25,031,000 | 27,220,000 | 25,763,000 | 32,629,000 | 15,370,000 | 10,758,000 | 3,862,000 | 3,901,000 | 3,370,000 | 2,809,000 | 4,784,000 | 3,091,000 | 2,802,000 | 2,882,000 | 2,782,000 | 2,338,000 | 2,575,000 | 1,943,000 | 3,305,000 | 5,525,000 | 2,796,000 | 2,298,000 | 3,283,000 | 1,938,000 | 1,679,000 |
selling, general and administrative | 406,212,000 | 530,647,000 | 358,399,000 | 514,013,000 | 369,287,000 | 325,772,000 | 338,523,000 | 351,712,000 | 396,034,000 | 308,310,000 | 340,844,000 | 297,917,000 | 383,203,000 | 358,478,000 | 366,473,000 | 308,813,000 | 398,462,000 | 363,682,000 | 429,031,000 | 260,508,000 | 247,172,000 | 207,255,000 | 191,406,000 | 208,400,000 | 214,275,000 | 178,706,000 | 176,014,000 | 167,947,000 | 161,865,000 | 155,873,000 | 158,579,000 | 207,213,000 | 143,050,000 | 124,523,000 | 132,328,000 | 144,255,000 | 127,141,000 | 124,368,000 | 122,618,000 | 128,765,000 | 125,555,000 | 104,044,000 | 107,132,000 | 112,388,000 | 105,694,000 | 93,501,000 | 100,556,000 | 106,363,000 | 81,299,000 | 74,970,000 | 77,506,000 | 70,528,000 | 61,377,000 | 60,924,000 | 60,638,000 | 46,999,000 | 36,384,000 | 30,547,000 | 22,094,000 | 19,911,000 | 17,070,000 | 18,040,000 | 17,096,000 | 16,790,000 | 15,718,000 | 15,061,000 | 13,657,000 | 14,216,000 | 20,183,000 | 24,329,000 | 34,109,000 | 32,780,000 | 27,957,000 | 18,069,000 | 18,175,000 |
research and development | 213,909,000 | 198,203,000 | 189,972,000 | 180,652,000 | 240,500,000 | 199,919,000 | 220,734,000 | 222,847,000 | 216,608,000 | 234,402,000 | 209,238,000 | 189,410,000 | 172,555,000 | 148,870,000 | 139,047,000 | 129,981,000 | 155,443,000 | 141,036,000 | 132,696,000 | 76,573,000 | 91,699,000 | 78,647,000 | 78,922,000 | 86,107,000 | 97,382,000 | 79,855,000 | 62,384,000 | 60,105,000 | 56,657,000 | 51,160,000 | 56,132,000 | 62,667,000 | 65,995,000 | 47,362,000 | 40,157,000 | 44,928,000 | 44,158,000 | 47,796,000 | 39,091,000 | 31,252,000 | 29,455,000 | 50,784,000 | 27,833,000 | 27,181,000 | 24,559,000 | 22,423,000 | 20,090,000 | 18,109,000 | 13,809,000 | 12,814,000 | 9,250,000 | 10,747,000 | 7,277,000 | 6,920,000 | 2,321,000 | 3,959,000 | 3,764,000 | 3,279,000 | 3,382,000 | 3,695,000 | 4,118,000 | 7,317,000 | 7,962,000 | 6,215,000 | 6,317,000 | 7,644,000 | 11,192,000 | 11,408,000 | 14,689,000 | 12,149,000 | 21,882,000 | 21,243,000 | 20,540,000 | 16,978,000 | 17,407,000 |
intangible asset amortization | 169,742,000 | 168,368,000 | 162,103,000 | 154,448,000 | 158,903,000 | 157,457,000 | 155,223,000 | 155,730,000 | 151,553,000 | 154,883,000 | 152,062,000 | 149,786,000 | 137,387,000 | 141,232,000 | 148,456,000 | 172,094,000 | 157,293,000 | 159,804,000 | 140,480,000 | 68,192,000 | 67,075,000 | 66,684,000 | 62,974,000 | 62,847,000 | 173,490,000 | 62,863,000 | 61,576,000 | 56,885,000 | 46,543,000 | 46,989,000 | 54,959,000 | 53,007,000 | 52,901,000 | 47,313,000 | 26,186,000 | 25,665,000 | 26,162,000 | 26,453,000 | 26,737,000 | 22,642,000 | 23,690,000 | 26,127,000 | 23,668,000 | 24,677,000 | 31,977,000 | 30,630,000 | 32,795,000 | 31,182,000 | 20,524,000 | 19,564,000 | 19,399,000 | 19,555,000 | 21,907,000 | 19,742,000 | 15,751,000 | 13,513,000 | 1,862,000 | 1,862,000 | 1,862,000 | 1,862,000 | 1,862,000 | 1,862,000 | 2,044,000 | 2,057,000 | |||||||||||
acquired in-process research and development | 42,500,000 | 905,362,000 | 10,000,000 | 18,000,000 | 1,000,000 | 375,000,000 | 69,148,000 | 36,000,000 | 10,000,000 | 3,000,000 | 202,250,000 | 51,775,000 | 2,200,000 | 56,000,000 | 8,000,000 | 75,000,000 | 2,000,000 | 15,000,000 | 8,750,000 | 626,000 | 75,000,000 | 127,000,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
total operating expenses | 943,391,000 | 1,068,598,000 | 1,732,104,000 | 953,733,000 | 897,403,000 | 794,759,000 | 824,382,000 | 835,776,000 | 889,438,000 | 799,748,000 | 799,681,000 | 766,757,000 | 1,235,509,000 | 915,889,000 | 847,332,000 | 726,172,000 | 847,351,000 | 809,746,000 | 821,401,000 | 445,462,000 | 492,103,000 | 404,681,000 | 364,310,000 | 724,400,000 | 520,495,000 | 404,599,000 | 329,850,000 | 374,443,000 | 291,402,000 | 280,596,000 | 347,280,000 | 356,806,000 | 295,194,000 | 325,401,000 | 229,343,000 | 239,913,000 | 231,117,000 | 237,928,000 | 212,426,000 | 214,848,000 | 234,253,000 | 209,340,000 | 180,446,000 | 192,544,000 | 198,223,000 | 248,548,000 | 216,939,000 | 313,578,000 | 141,275,000 | 131,600,000 | 131,186,000 | 128,050,000 | 116,324,000 | 120,215,000 | 94,080,000 | 75,229,000 | 45,872,000 | 39,589,000 | 30,708,000 | 28,277,000 | 27,834,000 | 30,310,000 | 29,904,000 | 27,944,000 | 26,874,000 | 27,100,000 | 29,246,000 | 29,299,000 | 71,314,000 | 45,490,000 | 62,633,000 | 58,442,000 | 74,221,000 | 39,272,000 | 57,017,000 |
income from operations | 254,535,000 | 57,509,000 | -686,392,000 | -55,892,000 | 190,770,000 | 260,210,000 | 199,443,000 | 66,207,000 | 122,497,000 | 172,392,000 | 157,636,000 | 126,055,000 | -263,386,000 | 24,763,000 | 85,546,000 | 87,549,000 | 49,380,000 | 28,369,000 | -69,590,000 | 162,119,000 | 173,414,000 | 196,207,000 | 198,126,000 | -189,674,000 | 61,245,000 | 133,103,000 | 204,283,000 | 133,743,000 | 185,055,000 | 188,777,000 | 153,199,000 | 87,807,000 | 141,205,000 | 86,454,000 | 165,043,000 | 136,140,000 | 165,504,000 | 136,253,000 | 168,735,000 | 121,162,000 | 106,628,000 | 131,532,000 | 153,301,000 | 116,759,000 | 129,919,000 | 58,036,000 | 74,291,000 | -66,659,000 | 94,499,000 | 100,560,000 | 77,066,000 | 68,187,000 | 67,379,000 | 55,300,000 | 35,459,000 | 33,185,000 | 37,664,000 | 33,704,000 | 33,859,000 | 22,604,000 | 25,535,000 | 14,443,000 | 10,582,000 | 7,229,000 | 11,410,000 | 3,709,000 | 8,034,000 | -7,223,000 | -51,719,000 | -27,744,000 | -47,094,000 | -43,808,000 | -58,744,000 | -17,798,000 | -42,753,000 |
yoy | 33.43% | -77.90% | -444.15% | -184.42% | 55.73% | 50.94% | 26.52% | -47.48% | -146.51% | 596.17% | 84.27% | 43.98% | -633.39% | -12.71% | -222.93% | -46.00% | -71.52% | -85.54% | -135.12% | -185.47% | 183.15% | 47.41% | -3.01% | -241.82% | -66.90% | -29.49% | 33.34% | 52.31% | 31.05% | 118.36% | -7.18% | -35.50% | -14.68% | -36.55% | -2.19% | 12.36% | 55.22% | 3.59% | 10.07% | 3.77% | -17.93% | 126.64% | 106.35% | -275.16% | 37.48% | -42.29% | -3.60% | -197.76% | 40.25% | 81.84% | 117.34% | 105.48% | 78.89% | 64.08% | 4.73% | 46.81% | 47.50% | 133.36% | 219.97% | 212.69% | 123.79% | 289.40% | 31.72% | -200.08% | -122.06% | -113.37% | -117.06% | -83.51% | -11.96% | 55.88% | 10.15% | ||||
qoq | 342.60% | -108.38% | 1128.07% | -129.30% | -26.69% | 30.47% | 201.24% | -45.95% | -28.94% | 9.36% | 25.05% | -147.86% | -1163.63% | -71.05% | -2.29% | 77.30% | 74.06% | -140.77% | -142.93% | -6.51% | -11.62% | -0.97% | -204.46% | -409.70% | -53.99% | -34.84% | 52.74% | -27.73% | -1.97% | 23.22% | 74.47% | -37.82% | 63.33% | -47.62% | 21.23% | -17.74% | 21.47% | -19.25% | 39.26% | 13.63% | -18.93% | -14.20% | 31.30% | -10.13% | 123.86% | -21.88% | -211.45% | -170.54% | -6.03% | 30.49% | 13.02% | 1.20% | 21.84% | 55.95% | 6.85% | -11.89% | 11.75% | -0.46% | 49.79% | -11.48% | 76.80% | 36.49% | 46.38% | -36.64% | 207.63% | -53.83% | -211.23% | -86.03% | 86.42% | -41.09% | 7.50% | -25.43% | 230.06% | -58.37% | |
operating margin % | 21.25% | 5.11% | -65.64% | -6.23% | 17.53% | 24.67% | 19.48% | 7.34% | 12.11% | 17.73% | 16.47% | 14.12% | -27.09% | 2.63% | 9.17% | 10.76% | 5.51% | 3.38% | -9.26% | 26.68% | 26.06% | 32.65% | 35.23% | -35.47% | 10.53% | 24.75% | 38.25% | 26.32% | 38.84% | 40.22% | 30.61% | 19.75% | 32.36% | 20.99% | 41.85% | 36.20% | 41.73% | 36.41% | 44.27% | 36.06% | 31.28% | 38.59% | 45.93% | 37.75% | 39.59% | 18.93% | 25.51% | -27.00% | 40.08% | 43.31% | 37.01% | 34.75% | 36.68% | 31.51% | 27.37% | 30.61% | 45.09% | 45.99% | 52.44% | 44.43% | 47.85% | 32.27% | 26.14% | 20.55% | 29.80% | 12.04% | 21.55% | -32.72% | -263.94% | -156.34% | -303.07% | -299.36% | -379.56% | -82.88% | -299.73% |
interest expense | -45,406,000 | -48,576,000 | -47,363,000 | -53,706,000 | -51,256,000 | -58,702,000 | -62,023,000 | -66,116,000 | -70,324,000 | -71,497,000 | -73,470,000 | -74,147,000 | -74,125,000 | -80,244,000 | -63,189,000 | -70,684,000 | -88,598,000 | -93,372,000 | -69,420,000 | -27,376,000 | -27,573,000 | -27,428,000 | -26,210,000 | -18,496,000 | -18,244,000 | -17,861,000 | -18,234,000 | -17,922,000 | -17,904,000 | -18,920,000 | -19,646,000 | -20,605,000 | -21,426,000 | -19,192,000 | -18,294,000 | -18,844,000 | -19,131,000 | -18,498,000 | -12,121,000 | -12,192,000 | -12,210,000 | -12,650,000 | -15,812,000 | -16,245,000 | -16,678,000 | -14,530,000 | -11,429,000 | -10,076,000 | -6,173,000 | -6,202,000 | -7,142,000 | -7,670,000 | -7,750,000 | -1,481,000 | -58,000 | -110,000 | -129,000 | -659,000 | -777,000 | -1,077,000 | -1,197,000 | -4,687,000 | -5,767,000 | -5,762,000 | -5,384,000 | -5,856,000 | -5,794,000 | -5,365,000 | -5,355,000 | -5,235,000 | -3,787,000 | -3,554,000 | -3,511,000 | -3,314,000 | |
foreign exchange gain | -658,000 | 102,000 | -1,799,000 | 507,000 | -1,693,000 | -2,382,000 | 3,193,000 | -4,133,000 | -4,649,000 | -1,343,000 | -10,540,000 | 315,500 | -2,631,000 | 2,950,000 | 943,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income before income tax benefit and equity in loss of investees | 208,471,000 | 9,035,000 | -735,554,000 | 133,219,000 | 200,807,000 | 137,927,000 | 59,100,750 | 99,518,000 | 81,784,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income tax benefit | 4,963,000 | -242,424,000 | -17,170,000 | -57,912,000 | -14,533,000 | -30,653,000 | -21,705,750 | -47,176,000 | -24,323,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
equity in loss of investees | 57,000 | 47,000 | 86,000 | 542,000 | 16,000 | 285,000 | 12,000 | 1,347,000 | 461,000 | -126,000 | 1,669,000 | 1,005,000 | 773,000 | 2,545,000 | 2,461,000 | 4,142,000 | 2,988,000 | 3,256,000 | -1,365,000 | 624,000 | 623,000 | 1,897,000 | -182,000 | 1,298,000 | 1,030,000 | 868,000 | 893,000 | 843,000 | 437,000 | 586,000 | 337,000 | 372,000 | 273,000 | ||||||||||||||||||||||||||||||||||||||||||
net income | 203,451,000 | 251,412,000 | -718,470,000 | -92,541,000 | 191,115,000 | 215,055,000 | 168,568,000 | -14,618,000 | 94,154,000 | 146,820,000 | 104,438,000 | 69,420,000 | -240,724,000 | -19,648,000 | 34,665,000 | 1,647,000 | -35,351,000 | -52,833,000 | -363,316,000 | 121,832,000 | 133,414,000 | 148,234,000 | 114,801,000 | -157,833,000 | 73,992,000 | 102,276,000 | 261,898,000 | 85,201,000 | 159,470,000 | 149,316,000 | 92,321,000 | 45,991,000 | 232,207,000 | 63,526,000 | 105,604,000 | 86,511,000 | 124,283,000 | 87,145,000 | 111,282,000 | 74,121,000 | 82,761,000 | 87,960,000 | 88,113,000 | 70,700,000 | 81,611,000 | 25,768,000 | 43,586,000 | -93,639,000 | 55,293,000 | 75,409,000 | 42,185,000 | 43,425,000 | 200,551,000 | 33,209,000 | 27,145,000 | 27,681,000 | 37,473,000 | 32,482,000 | 33,202,000 | 21,827,000 | 24,459,000 | 13,243,000 | -6,388,000 | 1,464,000 | 5,653,000 | -1,672,000 | 2,171,000 | -12,988,000 | -56,940,000 | -28,809,000 | -51,880,000 | -46,710,000 | -60,020,000 | -19,359,000 | -39,863,000 |
yoy | 6.45% | 16.91% | -526.22% | 533.06% | 102.98% | 46.48% | 61.40% | -121.06% | -139.11% | -847.25% | 201.28% | 4114.94% | 580.95% | -62.81% | -109.54% | -98.65% | -126.50% | -135.64% | -416.47% | -177.19% | 80.31% | 44.94% | -56.17% | -285.25% | -53.60% | -31.50% | 183.68% | 85.26% | -31.32% | 135.05% | -12.58% | -46.84% | 86.84% | -27.10% | -5.10% | 16.72% | 50.17% | -0.93% | 26.29% | 4.84% | 1.41% | 241.35% | 102.16% | -175.50% | 47.60% | -65.83% | 3.32% | -315.63% | -72.43% | 127.07% | 55.41% | 56.88% | 435.19% | 2.24% | -18.24% | 26.82% | 53.21% | 145.28% | -619.76% | 1390.92% | 332.67% | -892.05% | -394.24% | -111.27% | -109.93% | -94.20% | -104.18% | -72.19% | -5.13% | 48.81% | 30.15% | ||||
qoq | -19.08% | -134.99% | 676.38% | -148.42% | -11.13% | 27.58% | -1253.15% | -115.53% | -35.87% | 40.58% | 50.44% | -128.84% | 1125.18% | -156.68% | 2004.74% | -104.66% | -33.09% | -85.46% | -398.21% | -8.68% | -10.00% | 29.12% | -172.74% | -313.31% | -27.65% | -60.95% | 207.39% | -46.57% | 6.80% | 61.74% | 100.74% | -80.19% | 265.53% | -39.85% | 22.07% | -30.39% | 42.62% | -21.69% | 50.14% | -10.44% | -5.91% | -0.17% | 24.63% | -13.37% | 216.71% | -40.88% | -146.55% | -269.35% | -26.68% | 78.76% | -2.86% | -78.35% | 503.91% | 22.34% | -1.94% | -26.13% | 15.37% | -2.17% | 52.11% | -10.76% | 84.69% | -307.31% | -536.34% | -74.10% | -438.10% | -177.02% | -116.72% | -77.19% | 97.65% | -44.47% | 11.07% | -22.18% | 210.04% | -51.44% | |
net income margin % | 16.98% | 22.33% | -68.71% | -10.31% | 17.56% | 20.38% | 16.46% | -1.62% | 9.30% | 15.10% | 10.91% | 7.78% | -24.76% | -2.09% | 3.72% | 0.20% | -3.94% | -6.30% | -48.33% | 20.05% | 20.05% | 24.67% | 20.41% | -29.52% | 12.72% | 19.02% | 49.03% | 16.77% | 33.47% | 31.81% | 18.45% | 10.34% | 53.21% | 15.42% | 26.78% | 23.01% | 31.34% | 23.29% | 29.20% | 22.06% | 24.28% | 25.80% | 26.40% | 22.86% | 24.87% | 8.40% | 14.97% | -37.92% | 23.45% | 32.48% | 20.26% | 22.13% | 109.17% | 18.92% | 20.96% | 25.53% | 44.86% | 44.32% | 51.42% | 42.90% | 45.83% | 29.59% | -15.78% | 4.16% | 14.77% | -5.43% | 5.82% | -58.83% | -290.58% | -162.34% | -333.87% | -319.19% | -387.80% | -90.15% | -279.47% |
net income per ordinary share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic | 3,340 | 4,140 | -11,740 | 3,130 | 3,500 | 2,680 | -230 | 1,500 | 2,330 | 1,630 | 1,090 | -3,850 | -310 | 560 | 30 | -540 | -860 | -6,110 | 2,160 | 2,390 | 2,670 | 2,070 | -2,820 | 1,975 | 1,800 | 4,620 | 1,490 | 1,195 | 2,470 | 1,530 | 770 | 1,065 | 1,060 | 1,760 | 1,440 | 1,210 | -97.5 | 430 | 730 | -1,580 | 480 | 510 | 0.89 | 0.77 | 0.81 | 0.54 | 0.66 | 0.34 | -0.18 | 0.05 | 0.07 | ||||||||||||||||||||||||
diluted | 3,340 | 4,080 | -11,740 | 3,020 | 3,420 | 2,490 | -230 | 1,430 | 2,140 | 1,520 | 1,040 | -3,840 | -310 | 550 | 30 | -540 | -860 | -6,110 | 2,090 | 2,350 | 2,640 | 2,060 | -2,820 | 1,950 | 1,780 | 4,560 | 1,470 | 1,170 | 2,410 | 1,500 | 750 | 1,042.5 | 1,030 | 1,720 | 1,410 | 1,190 | -97.5 | 410 | 700 | -1,580 | 450 | 480 | 0.79 | 0.69 | 0.71 | 0.48 | 0.61 | 0.32 | -0.18 | 0.04 | 0.07 | ||||||||||||||||||||||||
weighted-average ordinary shares used in per share calculations - basic | 60,981 | 60,696 | 61,194 | 61,838 | 61,414 | 62,882 | 62,537 | 63,291 | 63,114 | 63,991 | 63,494 | 62,539 | 62,785 | 62,436 | 61,865 | 59,694 | 61,284 | 59,448 | 56,468 | 55,712 | 55,545 | 55,413 | 55,956 | 56,749 | 56,674 | 56,707 | 57,206 | 59,976 | 60,476 | 60,177 | 59,928 | 60,018 | 60,108 | 60,100 | 59,880 | 60,500 | 60,437 | 60,499 | 61,142 | ||||||||||||||||||||||||||||||||||||
weighted-average ordinary shares used in per share calculations - diluted | 60,981 | 61,606 | 61,194 | 66,007 | 63,174 | 69,625 | 62,537 | 72,066 | 71,293 | 73,540 | 73,771 | 62,539 | 62,785 | 63,431 | 62,907 | 59,694 | 61,284 | 59,448 | 58,393 | 56,517 | 56,236 | 55,864 | 55,956 | 57,550 | 57,438 | 57,427 | 58,081 | 61,221 | 61,857 | 61,438 | 61,178 | 61,317 | 61,436 | 61,463 | 61,178 | 61,870 | 61,644 | 61,833 | 62,474 | ||||||||||||||||||||||||||||||||||||
foreign exchange loss | -213,000 | -471,750 | -701,000 | -141,500 | -1,377,000 | -558,750 | -639,000 | -464,000 | -1,132,000 | -894,250 | -1,033,000 | -1,933,000 | -611,000 | -1,295,250 | -756,000 | -2,697,000 | -1,728,000 | -2,278,750 | -2,224,000 | -5,427,000 | -1,464,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
income before income tax (benefit) expense and equity in loss of investees | -109,811,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income tax (benefit) expense | -17,812,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income per ordinary share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted | -1,520 | -0.105 | -0.05 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
weighted-average ordinary shares used in per share calculations - basic and diluted | 60,979 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income before income tax expense and equity in loss of investees | -1,602,000 | 55,101,000 | 21,014,000 | 6,325,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income tax expense | 11,669,000 | -15,324,000 | -100,042,000 | -43,027,000 | -16,112,000 | 536,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
impairment charge | 133,648,000 | 34,034,750 | 136,139,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss before income tax expense and equity in loss of investees | -8,197,750 | -60,130,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income before income tax provision and equity in loss of investees | -17,002,000 | -67,634,000 | -136,060,000 | 144,805,000 | 168,140,000 | 171,452,000 | -209,302,000 | 40,767,000 | 114,209,000 | 184,116,000 | 115,210,000 | 165,457,000 | 169,101,000 | 129,431,000 | 65,474,000 | 118,925,000 | 65,038,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income tax provision | 57,145,750 | -18,057,000 | 228,621,000 | 18,019,000 | 10,767,000 | 19,283,000 | 54,754,000 | -51,287,000 | -34,523,000 | 10,903,000 | -78,650,000 | 29,116,000 | 5,144,000 | 19,348,000 | 36,524,000 | 19,146,000 | -113,654,000 | 1,239,000 | 35,515,000 | 29,160,000 | 26,754,000 | 29,120,000 | 45,332,000 | 34,030,000 | 13,748,000 | 29,945,000 | 30,647,000 | 32,059,000 | 33,633,000 | 24,221,000 | 19,350,000 | 17,027,000 | 32,064,000 | 18,335,000 | 23,605,000 | 17,634,000 | |||||||||||||||||||||||||||||||||||||||
income before income tax provision and equity in gain of investees | 135,686,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
equity in gain of investees | -4,165,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
impairment charges | 42,896,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on extinguishment and modification of debt | -1,425,000 | -638,000 | -16,815,000 | -3,749,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income before income tax provision and equity in loss of investee | 141,322,000 | 115,832,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
equity in loss of investee | 203,000 | 161,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
foreign currency loss | -392,000 | -749,000 | -969,000 | -614,000 | -385,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income before income tax provision and equity in loss of investee, net of tax | 95,283,250 | 116,368,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
equity in loss of investee, net of tax | 25,750 | 103,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net loss attributable to noncontrolling interests, net of tax | -1,000 | -73,000 | -989,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income attributable to jazz pharmaceuticals plc | 124,283,000 | 87,145,000 | 111,282,000 | 82,761,000 | 87,960,000 | 88,114,000 | 70,700,000 | 81,612,000 | 25,766,000 | 43,659,000 | -92,650,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income attributable to jazz pharmaceuticals plc per ordinary share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic | 1,122.5 | 1,440 | 1,840 | 1,010 | 1,430 | 1,440 | 1,160 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
diluted | 1,100 | 1,410 | 1,800 | 977.5 | 1,390 | 1,400 | 1,120 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
foreign currency gain | -819,000 | 2,091,000 | -977,000 | -1,914,000 | 2,245,000 | 2,003,000 | 6,483,000 | 74,000 | 123,000 | 271,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income before income tax provision | 156,614,000 | 108,151,000 | 84,856,000 | 117,905,000 | 118,760,000 | 102,759,000 | 9,078,250 | 49,989,000 | 62,936,000 | -76,612,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income attributable to noncontrolling interests, net of tax | -250 | -265,000 | 2,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
weighted-average ordinary shares used in per share calculation - basic | 61,232 | 61,435 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
weighted-average ordinary shares used in per share calculation - diluted | 63,036 | 63,154 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
weighted-average ordinary shares used in calculating net income attributable to jazz pharmaceuticals plc per ordinary share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic | 61,190,000 | 60,803,000 | 59,746,000 | 60,305,000 | 59,519,000 | 58,526,000 | 58,298,000 | 58,217 | 58,737 | 58,358 | 56,643,000 | 57,703 | 56,952 | 53,923 | 41,499 | 42,028 | 41,209 | 40,362 | 36,343 | 38,965 | 35,423 | 31,412 | 29,021 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
diluted | 63,090,000 | 62,964,000 | 62,614,000 | 62,680,000 | 62,378,000 | 58,526,000 | 61,569,000 | 61,519 | 61,568 | 61,511 | 60,195,000 | 60,883 | 60,554 | 58,084 | 46,798 | 47,241 | 46,601 | 45,697 | 39,411 | 41,737 | 35,423 | 34,926 | 29,023 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
intangible asset impairment | 8,201,500 | 32,806,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income per ordinary share attributable to jazz pharmaceuticals plc: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic | 3,340 | 4,140 | -11,740 | 3,130 | 3,500 | 2,680 | -230 | 1,500 | 2,330 | 1,630 | 1,090 | -3,850 | -310 | 560 | 30 | -540 | -860 | -6,110 | 2,160 | 2,390 | 2,670 | 2,070 | -2,820 | 1,975 | 1,800 | 4,620 | 1,490 | 1,195 | 2,470 | 1,530 | 770 | 1,065 | 1,060 | 1,760 | 1,440 | 1,210 | -97.5 | 430 | 730 | -1,580 | 480 | 510 | 0.89 | 0.77 | 0.81 | 0.54 | 0.66 | 0.34 | -0.18 | 0.05 | 0.07 | ||||||||||||||||||||||||
diluted | 3,340 | 4,080 | -11,740 | 3,020 | 3,420 | 2,490 | -230 | 1,430 | 2,140 | 1,520 | 1,040 | -3,840 | -310 | 550 | 30 | -540 | -860 | -6,110 | 2,090 | 2,350 | 2,640 | 2,060 | -2,820 | 1,950 | 1,780 | 4,560 | 1,470 | 1,170 | 2,410 | 1,500 | 750 | 1,042.5 | 1,030 | 1,720 | 1,410 | 1,190 | -97.5 | 410 | 700 | -1,580 | 450 | 480 | 0.79 | 0.69 | 0.71 | 0.48 | 0.61 | 0.32 | -0.18 | 0.04 | 0.07 | ||||||||||||||||||||||||
weighted-average ordinary shares used in calculating net income per ordinary share attributable to jazz pharmaceuticals plc: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic | 61,190,000 | 60,803,000 | 59,746,000 | 60,305,000 | 59,519,000 | 58,526,000 | 58,298,000 | 58,217 | 58,737 | 58,358 | 56,643,000 | 57,703 | 56,952 | 53,923 | 41,499 | 42,028 | 41,209 | 40,362 | 36,343 | 38,965 | 35,423 | 31,412 | 29,021 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
diluted | 63,090,000 | 62,964,000 | 62,614,000 | 62,680,000 | 62,378,000 | 58,526,000 | 61,569,000 | 61,519 | 61,568 | 61,511 | 60,195,000 | 60,883 | 60,554 | 58,084 | 46,798 | 47,241 | 46,601 | 45,697 | 39,411 | 41,737 | 35,423 | 34,926 | 29,023 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
income from continuing operations before income tax provision | 87,357,000 | 93,744,000 | 65,790,000 | 61,059,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income from continuing operations | 55,293,000 | 75,409,000 | 42,185,000 | 43,425,000 | 166,206,000 | 33,595,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss from discontinued operations | -1,727,000 | -386,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic income per ordinary share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
diluted income per ordinary share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
weighted-average ordinary shares used in per share computations: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic | 61,190,000 | 60,803,000 | 59,746,000 | 60,305,000 | 59,519,000 | 58,526,000 | 58,298,000 | 58,217 | 58,737 | 58,358 | 56,643,000 | 57,703 | 56,952 | 53,923 | 41,499 | 42,028 | 41,209 | 40,362 | 36,343 | 38,965 | 35,423 | 31,412 | 29,021 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
diluted | 63,090,000 | 62,964,000 | 62,614,000 | 62,680,000 | 62,378,000 | 58,526,000 | 61,569,000 | 61,519 | 61,568 | 61,511 | 60,195,000 | 60,883 | 60,554 | 58,084 | 46,798 | 47,241 | 46,601 | 45,697 | 39,411 | 41,737 | 35,423 | 34,926 | 29,023 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
interest income | -7,399,000 | 1,000 | 1,000 | 1,000 | 2,000 | 2,000 | 5,000 | 2,000 | 6,000 | 21,000 | 134,000 | 353,000 | 450,000 | 897,000 | 1,582,000 | 1,969,000 | 1,300,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
foreign exchange and other | -339,250 | -1,099,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on extinguishment of debt | -150,000 | -1,097,000 | -12,287,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income from continuing operations before provision for income tax expense | 29,977,250 | 46,451,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
provision for income tax expense | 6,241,500 | 12,856,000 | 6,593,000 | 5,517,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other expense | -240,000 | -1,000 | -13,000 | -12,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income before provision for income tax expense | 33,738,000 | 33,198,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
weighted-average ordinary shares used in computing net income per share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic | 61,190,000 | 60,803,000 | 59,746,000 | 60,305,000 | 59,519,000 | 58,526,000 | 58,298,000 | 58,217 | 58,737 | 58,358 | 56,643,000 | 57,703 | 56,952 | 53,923 | 41,499 | 42,028 | 41,209 | 40,362 | 36,343 | 38,965 | 35,423 | 31,412 | 29,021 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
diluted | 63,090,000 | 62,964,000 | 62,614,000 | 62,680,000 | 62,378,000 | 58,526,000 | 61,569,000 | 61,519 | 61,568 | 61,511 | 60,195,000 | 60,883 | 60,554 | 58,084 | 46,798 | 47,241 | 46,601 | 45,697 | 39,411 | 41,737 | 35,423 | 34,926 | 29,023 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
interest income and other | 71,000 | 69,000 | 4,000 | 2,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
royalties | 576,000 | 792,000 | 819,000 | 693,000 | 728,000 | 630,000 | 674,000 | 605,000 | 681,000 | 532,000 | 518,000 | 472,000 | 431,000 | 440,000 | 503,000 | 365,000 | 332,000 | 253,000 | 360,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
contract revenues | 213,500 | 285,000 | 284,000 | 285,000 | 284,000 | 285,000 | 284,000 | 285,000 | 284,000 | 285,000 | 10,284,000 | 285,000 | 284,000 | 284,000 | 285,000 | 285,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income per share | -0.45 | -1.28 | -1.07 | -2.17 | -1.97 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic | 3,340 | 4,140 | -11,740 | 3,130 | 3,500 | 2,680 | -230 | 1,500 | 2,330 | 1,630 | 1,090 | -3,850 | -310 | 560 | 30 | -540 | -860 | -6,110 | 2,160 | 2,390 | 2,670 | 2,070 | -2,820 | 1,975 | 1,800 | 4,620 | 1,490 | 1,195 | 2,470 | 1,530 | 770 | 1,065 | 1,060 | 1,760 | 1,440 | 1,210 | -97.5 | 430 | 730 | -1,580 | 480 | 510 | 0.89 | 0.77 | 0.81 | 0.54 | 0.66 | 0.34 | -0.18 | 0.05 | 0.07 | ||||||||||||||||||||||||
diluted | 3,340 | 4,080 | -11,740 | 3,020 | 3,420 | 2,490 | -230 | 1,430 | 2,140 | 1,520 | 1,040 | -3,840 | -310 | 550 | 30 | -540 | -860 | -6,110 | 2,090 | 2,350 | 2,640 | 2,060 | -2,820 | 1,950 | 1,780 | 4,560 | 1,470 | 1,170 | 2,410 | 1,500 | 750 | 1,042.5 | 1,030 | 1,720 | 1,410 | 1,190 | -97.5 | 410 | 700 | -1,580 | 450 | 480 | 0.79 | 0.69 | 0.71 | 0.48 | 0.61 | 0.32 | -0.18 | 0.04 | 0.07 | ||||||||||||||||||||||||
weighted-average common shares used in computing net income per share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic | 61,190,000 | 60,803,000 | 59,746,000 | 60,305,000 | 59,519,000 | 58,526,000 | 58,298,000 | 58,217 | 58,737 | 58,358 | 56,643,000 | 57,703 | 56,952 | 53,923 | 41,499 | 42,028 | 41,209 | 40,362 | 36,343 | 38,965 | 35,423 | 31,412 | 29,021 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
diluted | 63,090,000 | 62,964,000 | 62,614,000 | 62,680,000 | 62,378,000 | 58,526,000 | 61,569,000 | 61,519 | 61,568 | 61,511 | 60,195,000 | 60,883 | 60,554 | 58,084 | 46,798 | 47,241 | 46,601 | 45,697 | 39,411 | 41,737 | 35,423 | 34,926 | 29,023 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
other income | -4,000 | 2,000 | 1,000 | 8,000 | 10,000 | 19,000 | -1,000 | -19,000 | -19,000 | 4,904,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of intangible assets | 1,402,750 | 2,057,000 | 1,822,000 | 1,732,000 | 2,363,500 | 3,487,000 | 3,846,000 | 2,121,000 | 1,734,000 | 2,287,000 | 2,287,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale of product rights | 3,918,000 | 715,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income per share | -0.45 | -1.28 | -1.07 | -2.17 | -1.97 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted | -1,520 | -0.105 | -0.05 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
weighted-average common shares used in computing net loss per share: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted | 30,895 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income per share | -0.45 | -1.28 | -1.07 | -2.17 | -1.97 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
weighted-average common shares used in computing net loss per share, basic and diluted | 30,018 | 28,925 | 26,994 | 23,858 | 23,743 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
provision for government settlement | 17,469,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
contract revenue | 2,581,500 | 7,785,000 | 289,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on extinguishment of development financing obligation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
beneficial conversion feature | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income attributable to common stockholders | -19,701,500 | -19,359,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income per share attributable to common stockholders, basic | -1.875 | -0.82 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
weighted-average common shares used in computing income per share attributable to common stockholders, basic | 23,671 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income per share attributable to common stockholders, diluted | -1.875 | -0.82 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shares used in computing income per share attributable to common stockholders, diluted | 2,626.25 | 23,671 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss attributable to common stockholders | -39,863,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss per share attributable to common stockholders, basic and diluted | -5.27 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
weighted-average common shares used in computing loss per share attributable to common stockholders, basic and diluted | 25,646 | 13,829 | 7,561 |
Balance Sheets:
Quarterly
Annual
| Unit: USD | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-12-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-12-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-12-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 | 2013-12-31 | 2013-09-30 | 2013-06-30 | 2013-03-31 | 2012-12-31 | 2012-09-30 | 2012-06-30 | 2012-03-31 | 2011-12-31 | 2011-09-30 | 2011-06-30 | 2011-03-31 | 2010-12-31 | 2010-09-30 | 2010-06-30 | 2010-03-31 | 2009-12-31 | 2009-09-30 | 2009-06-30 | 2009-03-31 | 2008-12-31 | 2008-09-30 | 2008-06-30 | 2008-03-31 | 2007-12-31 | 2007-09-30 | 2007-06-30 |
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assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current assets: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents | 1,391,899,000 | 1,326,070,000 | 1,189,880,000 | 1,861,946,000 | 2,412,864,000 | 2,218,135,000 | 1,355,802,000 | 1,443,385,000 | 1,506,310,000 | 1,335,690,000 | 1,282,304,000 | 1,167,911,000 | 881,482,000 | 839,358,000 | 711,265,000 | 490,835,000 | 591,448,000 | 671,780,000 | 891,400,000 | 2,097,533,000 | 1,057,769,000 | 741,942,000 | 786,082,000 | 701,602,000 | 637,344,000 | 795,175,000 | 637,739,000 | 547,466,000 | 309,622,000 | 499,018,000 | 485,081,000 | 453,169,000 | 386,035,000 | 252,615,000 | 239,213,000 | 346,995,000 | 365,963,000 | 366,567,000 | 867,966,000 | 979,780,000 | 988,785,000 | 998,859,000 | 921,643,000 | 782,603,000 | 684,042,000 | 575,040,000 | 268,255,000 | 245,874,000 | 636,504,000 | 588,462,000 | 504,307,000 | 450,511,000 | 387,196,000 | 189,793,000 | 154,543,000 | 170,654,000 | 82,076,000 | 101,215,000 | 102,396,000 | 65,061,000 | 44,794,000 | 22,853,000 | 9,574,000 | 18,998,000 | 15,595,000 | 12,230,000 | 15,772,000 | 17,015,000 | 24,903,000 | 49,907,000 | 51,202,000 | 100,771,000 | 102,945,000 | 119,972,000 | 148,000,000 |
investments | 1,050,000,000 | 720,000,000 | 480,000,000 | 710,000,000 | 580,000,000 | 400,000,000 | 625,000,000 | 375,000,000 | 120,000,000 | 250,000,000 | 80,000,000 | 60,000,000 | 60,000,000 | 335,000,000 | 1,075,000,000 | 1,175,000,000 | 910,000,000 | 280,000,000 | 440,000,000 | 275,000,000 | 245,000,000 | 285,000,000 | 515,000,000 | 565,000,000 | 330,000,000 | 255,000,000 | 215,000,000 | 200,000,000 | 80,000,000 | 60,000,000 | 60,000,000 | 59,418,000 | 48,409,000 | 764,000 | 5,502,000 | ||||||||||||||||||||||||||||||||||||||||
accounts receivable | 830,747,000 | 764,364,000 | 714,004,000 | 652,992,000 | 716,765,000 | 723,639,000 | 698,037,000 | 707,095,000 | 705,794,000 | 627,841,000 | 610,389,000 | 623,938,000 | 651,493,000 | 601,179,000 | 594,034,000 | 572,392,000 | 563,360,000 | 499,023,000 | 506,660,000 | 413,976,000 | 396,490,000 | 361,664,000 | 351,920,000 | 317,301,000 | 355,987,000 | 267,031,000 | 311,249,000 | 320,485,000 | 263,838,000 | 279,437,000 | 278,441,000 | 281,424,000 | 224,129,000 | 258,616,000 | 238,752,000 | 243,035,000 | 234,244,000 | 238,072,000 | 231,837,000 | 223,802,000 | 209,685,000 | 195,816,000 | 193,647,000 | 189,682,000 | 186,371,000 | 187,604,000 | 160,775,000 | 154,986,000 | 124,805,000 | 113,271,000 | 114,075,000 | 93,833,000 | 75,480,000 | 88,304,000 | 78,130,000 | 56,143,000 | 34,374,000 | 31,428,000 | 24,999,000 | 21,383,000 | 22,081,000 | 14,114,000 | 14,095,000 | 11,955,000 | 12,313,000 | 9,202,000 | 9,197,000 | 7,012,000 | 6,643,000 | 6,686,000 | 5,221,000 | 5,310,000 | 5,389,000 | 6,566,000 | 6,462,000 |
inventories | 416,962,000 | 483,111,000 | 504,989,000 | 492,776,000 | 480,445,000 | 539,302,000 | 542,555,000 | 577,321,000 | 597,039,000 | 611,827,000 | 657,214,000 | 674,778,000 | 714,061,000 | 728,074,000 | 861,705,000 | 985,454,000 | 1,072,721,000 | 1,137,851,000 | 1,251,259,000 | 115,475,000 | 95,396,000 | 91,404,000 | 92,534,000 | 85,610,000 | 78,608,000 | 71,108,000 | 68,999,000 | 60,707,000 | 52,956,000 | 43,435,000 | 46,156,000 | 46,384,000 | 43,245,000 | 41,344,000 | 39,658,000 | 37,653,000 | 34,051,000 | 32,351,000 | 33,291,000 | 25,369,000 | 19,451,000 | 30,018,000 | 30,781,000 | 30,692,000 | 30,037,000 | 37,612,000 | 33,098,000 | 36,988,000 | 28,669,000 | 24,868,000 | 28,130,000 | 22,830,000 | 26,525,000 | 30,300,000 | 48,355,000 | 16,992,000 | 3,909,000 | 4,297,000 | 4,736,000 | 5,017,000 | 5,046,000 | 4,476,000 | 4,429,000 | 3,522,000 | 3,426,000 | 4,532,000 | 4,193,000 | 4,430,000 | 4,788,000 | 6,264,000 | 6,219,000 | 2,200,000 | 2,213,000 | 3,231,000 | 3,216,000 |
prepaid expenses | 152,481,000 | 146,892,000 | 164,000,000 | 150,280,000 | 177,411,000 | 155,132,000 | 134,421,000 | 122,562,000 | 185,476,000 | 109,990,000 | 107,490,000 | 72,779,000 | 91,912,000 | 92,877,000 | 108,304,000 | 117,399,000 | 131,413,000 | 94,474,000 | 104,455,000 | 57,185,000 | 62,422,000 | 58,305,000 | 49,109,000 | 38,824,000 | 39,434,000 | 30,841,000 | 31,712,000 | 28,974,000 | 25,017,000 | 23,189,000 | 33,586,000 | 27,476,000 | 23,182,000 | 29,249,000 | 28,433,000 | 38,118,000 | 24,501,000 | 23,304,000 | 23,143,000 | 18,472,000 | 20,699,000 | 21,275,000 | 26,250,000 | 27,614,000 | 12,800,000 | 24,206,000 | 28,447,000 | 14,335,000 | 7,183,000 | 19,350,000 | 21,410,000 | 11,286,000 | 7,445,000 | 7,127,000 | 5,906,000 | 5,714,000 | 1,690,000 | 2,535,000 | 3,575,000 | 2,577,000 | 1,858,000 | 1,992,000 | 2,287,000 | 2,324,000 | 1,653,000 | 1,969,000 | 2,426,000 | 2,206,000 | 2,366,000 | 3,114,000 | 3,680,000 | 3,210,000 | 3,224,000 | 2,392,000 | 2,655,000 |
other current assets | 323,954,000 | 315,441,000 | 297,560,000 | 259,823,000 | 261,543,000 | 354,215,000 | 325,851,000 | 314,535,000 | 320,809,000 | 310,404,000 | 272,458,000 | 245,244,000 | 267,192,000 | 250,016,000 | 255,525,000 | 243,888,000 | 252,392,000 | 225,098,000 | 200,190,000 | 147,727,000 | 152,491,000 | 127,258,000 | 112,701,000 | 94,300,000 | 78,895,000 | 81,401,000 | 75,367,000 | 62,985,000 | 67,572,000 | 54,310,000 | 55,634,000 | 62,868,000 | 76,686,000 | 49,120,000 | 36,448,000 | 27,052,000 | 29,310,000 | 24,517,000 | 26,244,000 | 22,431,000 | 19,047,000 | 18,969,000 | 21,985,000 | 21,522,000 | 21,322,000 | 18,362,000 | 18,468,000 | 23,747,000 | 33,843,000 | 18,551,000 | 19,716,000 | 21,395,000 | 19,113,000 | 9,942,000 | 13,508,000 | 4,073,000 | 1,260,000 | 532,000 | 382,000 | 402,000 | 279,000 | 962,000 | 788,000 | 992,000 | 979,000 | 261,000 | 62,000 | 2,106,000 | 2,382,000 | 736,000 | 376,000 | 1,346,000 | 381,000 | 1,574,000 | 547,000 |
total current assets | 4,166,043,000 | 3,755,878,000 | 3,350,433,000 | 4,127,817,000 | 4,629,028,000 | 4,390,423,000 | 3,681,666,000 | 3,539,898,000 | 3,435,428,000 | 3,245,752,000 | 3,009,855,000 | 2,784,650,000 | 2,606,140,000 | 2,571,504,000 | 2,590,833,000 | 2,500,856,000 | 2,611,334,000 | 2,628,226,000 | 2,953,964,000 | 3,166,896,000 | 2,839,568,000 | 2,555,573,000 | 2,302,346,000 | 1,517,637,000 | 1,630,268,000 | 1,520,556,000 | 1,370,066,000 | 1,305,617,000 | 1,234,005,000 | 1,464,389,000 | 1,306,931,000 | 1,126,321,000 | 968,277,000 | 830,944,000 | 662,504,000 | 752,853,000 | 748,069,000 | 744,229,000 | 1,230,890,000 | 1,270,618,000 | 1,257,667,000 | 1,314,943,000 | 1,244,910,000 | 1,102,935,000 | 1,015,845,000 | 878,520,000 | 544,912,000 | 517,320,000 | 864,617,000 | 810,067,000 | 734,176,000 | 647,372,000 | 551,572,000 | 385,012,000 | 300,442,000 | 327,140,000 | 199,131,000 | 152,140,000 | 136,088,000 | 94,840,000 | 74,458,000 | 44,797,000 | 32,083,000 | 38,742,000 | 36,954,000 | 29,144,000 | 32,725,000 | 33,544,000 | 43,999,000 | 69,704,000 | 70,196,000 | 119,245,000 | 116,091,000 | 144,978,000 | 161,155,000 |
property, plant and equipment | 199,857,000 | 188,913,000 | 184,975,000 | 178,869,000 | 173,413,000 | 176,422,000 | 169,281,000 | 166,236,000 | 169,646,000 | 222,476,000 | 229,264,000 | 227,552,000 | 228,050,000 | 216,339,000 | 239,523,000 | 257,632,000 | 256,837,000 | 255,006,000 | 277,066,000 | 123,863,000 | 127,935,000 | 128,204,000 | 128,259,000 | 129,562,000 | 131,506,000 | 129,472,000 | 127,183,000 | 113,006,000 | 200,358,000 | 198,053,000 | 188,086,000 | 178,920,000 | |||||||||||||||||||||||||||||||||||||||||||
operating lease assets | 58,880,000 | 61,204,000 | 63,082,000 | 49,181,000 | 53,582,000 | 77,164,000 | 73,145,000 | 61,637,000 | 65,340,000 | 65,038,000 | 69,040,000 | 75,538,000 | 73,326,000 | 73,728,000 | 78,365,000 | 83,412,000 | 86,586,000 | 89,628,000 | 149,254,000 | 125,738,000 | 129,169,000 | 130,717,000 | 133,179,000 | 135,976,000 | 139,385,000 | 141,878,000 | 144,746,000 | 147,365,000 | |||||||||||||||||||||||||||||||||||||||||||||||
intangible assets | 4,429,510,000 | 4,565,737,000 | 4,768,987,000 | 4,718,158,000 | 4,755,695,000 | 5,144,217,000 | 5,079,462,000 | 5,235,496,000 | 5,418,039,000 | 5,417,860,000 | 5,705,777,000 | 5,764,209,000 | 5,794,437,000 | 5,570,394,000 | 6,237,959,000 | 6,783,057,000 | 7,152,328,000 | 7,282,579,000 | 7,588,029,000 | 2,108,046,000 | 2,195,051,000 | 2,241,107,000 | 2,286,126,000 | 2,238,658,000 | 2,440,977,000 | 2,593,030,000 | 2,687,941,000 | 2,679,393,000 | 2,731,334,000 | 2,787,281,000 | 2,842,277,000 | 2,953,146,000 | 2,979,127,000 | 3,019,035,000 | 3,033,103,000 | 2,998,780,000 | 3,012,001,000 | 3,110,439,000 | 1,300,761,000 | 1,348,160,000 | 1,185,606,000 | 1,270,777,000 | 1,282,955,000 | 1,284,308,000 | 1,437,435,000 | 1,550,624,000 | 1,680,004,000 | 1,755,861,000 | 812,396,000 | 823,724,000 | 822,976,000 | 835,003,000 | 869,952,000 | 876,959,000 | 927,409,000 | 326,072,000 | 14,585,000 | 16,447,000 | 18,309,000 | 20,171,000 | 22,033,000 | 23,895,000 | 25,757,000 | 27,802,000 | 29,858,000 | 31,915,000 | 33,972,000 | 35,794,000 | 32,526,000 | 65,663,000 | 71,074,000 | 74,919,000 | 36,040,000 | 58,664,000 | 60,952,000 |
goodwill | 1,829,340,000 | 1,827,483,000 | 1,843,974,000 | 1,760,045,000 | 1,716,323,000 | 1,804,646,000 | 1,735,931,000 | 1,739,495,000 | 1,753,130,000 | 1,705,320,000 | 1,742,675,000 | 1,723,444,000 | 1,692,662,000 | 1,592,635,000 | 1,687,648,000 | 1,782,444,000 | 1,827,609,000 | 1,849,547,000 | 1,887,699,000 | 938,398,000 | 958,303,000 | 937,099,000 | 918,021,000 | 909,226,000 | 920,018,000 | 906,725,000 | 924,990,000 | 919,972,000 | 927,630,000 | 932,422,000 | 936,493,000 | 960,509,000 | 947,537,000 | 941,428,000 | 926,290,000 | 899,290,000 | 893,810,000 | 927,993,000 | 661,845,000 | 670,991,000 | 657,139,000 | 669,029,000 | 664,015,000 | 654,470,000 | 702,713,000 | 724,388,000 | 760,314,000 | 763,763,000 | 450,456,000 | 446,823,000 | 439,014,000 | 436,355,000 | 442,600,000 | 437,652,000 | 446,236,000 | 239,737,000 | 38,213,000 | 38,213,000 | 38,213,000 | 38,213,000 | 38,213,000 | 38,213,000 | 38,213,000 | 38,213,000 | 38,213,000 | 38,213,000 | 38,213,000 | 38,213,000 | 38,213,000 | 38,213,000 | 38,213,000 | 38,213,000 | 38,213,000 | 38,213,000 | 38,213,000 |
deferred tax assets | 869,130,000 | 846,168,000 | 602,903,000 | 575,097,000 | 560,245,000 | 583,218,000 | 545,222,000 | 507,749,000 | 477,834,000 | 464,367,000 | 430,086,000 | 399,097,000 | 376,247,000 | 314,965,000 | 320,550,000 | 314,672,000 | 311,103,000 | 314,666,000 | 296,493,000 | 258,454,000 | 254,916,000 | 254,810,000 | 243,395,000 | 230,242,000 | 221,403,000 | 183,944,000 | 184,383,000 | 65,090,000 | 57,879,000 | 37,582,000 | 40,997,000 | 38,103,000 | 34,559,000 | 50,006,000 | 50,604,000 | 50,822,000 | 48,440,000 | 35,696,000 | 35,869,000 | 35,888,000 | 33,613,000 | 45,565,000 | 46,538,000 | 47,517,000 | 35,813,000 | ||||||||||||||||||||||||||||||
deferred financing costs | 7,550,000 | 8,034,000 | 8,516,000 | 8,999,000 | 9,489,000 | 4,395,000 | 5,736,000 | 5,784,000 | 6,478,000 | 7,172,000 | 7,865,000 | 8,559,000 | 9,254,000 | 9,949,000 | 10,643,000 | 11,336,000 | 12,029,000 | 12,724,000 | 13,406,000 | 4,724,000 | 5,238,000 | 5,802,000 | 6,347,000 | 6,887,000 | 7,426,000 | 7,971,000 | 8,517,000 | 9,056,000 | 9,589,000 | 10,058,000 | 10,779,000 | 7,144,000 | 7,673,000 | 8,149,000 | 8,705,000 | 9,325,000 | 9,737,000 | 10,258,000 | 6,610,000 | 6,843,000 | 23,268,000 | 24,315,000 | 25,188,000 | 31,223,000 | 33,174,000 | 35,068,000 | 24,427,000 | 25,896,000 | 14,605,000 | 15,458,000 | 16,308,000 | 15,686,000 | 16,576,000 | ||||||||||||||||||||||
other non-current assets | 99,030,000 | 103,068,000 | 121,271,000 | 116,516,000 | 114,482,000 | 75,231,000 | 71,425,000 | 70,780,000 | 67,464,000 | 76,080,000 | 65,978,000 | 64,076,000 | 55,139,000 | 35,153,000 | 34,612,000 | 35,508,000 | 40,813,000 | 45,776,000 | 47,082,000 | 30,351,000 | 25,721,000 | 38,646,000 | 48,828,000 | 47,107,000 | 47,914,000 | 44,274,000 | 40,835,000 | 40,736,000 | 42,696,000 | 56,003,000 | 23,404,000 | 22,985,000 | 16,419,000 | 16,420,000 | 16,638,000 | 17,625,000 | 14,060,000 | 37,764,000 | 37,005,000 | 29,543,000 | 27,548,000 | 25,393,000 | 22,498,000 | 19,189,000 | 15,931,000 | 13,482,000 | 11,135,000 | 9,296,000 | 7,304,000 | 6,391,000 | 5,502,000 | ||||||||||||||||||||||||
total assets | 11,659,340,000 | 11,356,485,000 | 10,944,141,000 | 11,534,682,000 | 12,012,257,000 | 12,255,716,000 | 11,361,868,000 | 11,327,075,000 | 11,393,359,000 | 11,204,065,000 | 11,260,540,000 | 11,047,125,000 | 10,835,255,000 | 10,384,667,000 | 11,200,133,000 | 11,768,917,000 | 12,298,639,000 | 12,478,152,000 | 13,212,993,000 | 6,756,470,000 | 6,535,901,000 | 6,291,958,000 | 6,066,501,000 | 5,215,295,000 | 5,538,897,000 | 5,527,850,000 | 5,488,661,000 | 5,280,235,000 | 5,203,491,000 | 5,485,788,000 | 5,348,967,000 | 5,287,128,000 | 5,123,672,000 | 4,999,024,000 | 4,804,024,000 | 4,815,824,000 | 4,800,227,000 | 4,930,581,000 | 3,448,094,000 | 3,534,979,000 | 3,359,663,000 | 3,464,300,000 | 3,393,274,000 | 3,237,593,000 | 3,338,955,000 | 3,347,536,000 | 3,155,749,000 | 3,196,434,000 | 2,238,221,000 | 2,185,499,000 | 2,093,880,000 | 2,009,690,000 | 1,966,493,000 | 1,726,699,000 | 1,697,944,000 | 895,360,000 | 253,573,000 | 207,813,000 | 193,409,000 | 154,178,000 | 135,729,000 | 107,992,000 | 97,264,000 | 106,706,000 | 107,396,000 | 102,172,000 | 108,574,000 | 109,937,000 | 117,498,000 | 179,793,000 | 186,591,000 | 239,018,000 | 207,554,000 | 258,767,000 | 276,870,000 |
liabilities and shareholders’ equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current liabilities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts payable | 122,061,000 | 152,227,000 | 89,366,000 | 95,930,000 | 77,869,000 | 85,425,000 | 97,096,000 | 80,976,000 | 102,750,000 | 109,850,000 | 98,428,000 | 125,454,000 | 90,758,000 | 102,249,000 | 74,161,000 | 73,336,000 | 100,298,000 | 63,815,000 | 64,826,000 | 77,738,000 | 26,945,000 | 67,063,000 | 50,043,000 | 66,308,000 | 47,545,000 | 70,104,000 | 82,222,000 | 42,669,000 | 40,602,000 | 37,373,000 | 31,379,000 | 46,933,000 | 24,368,000 | 29,972,000 | 28,529,000 | 29,144,000 | 22,415,000 | 17,626,000 | 28,406,000 | 32,622,000 | 21,807,000 | 29,124,000 | 26,409,000 | 27,317,000 | 25,126,000 | 29,671,000 | 32,555,000 | 72,538,000 | 21,005,000 | 22,434,000 | 20,367,000 | 31,634,000 | 15,887,000 | 20,535,000 | 34,505,000 | 13,689,000 | 5,129,000 | 8,463,000 | 4,665,000 | 3,648,000 | 3,049,000 | 3,891,000 | 6,403,000 | 3,885,000 | 2,158,000 | 5,240,000 | 4,074,000 | 4,554,000 | 5,736,000 | 6,614,000 | 8,522,000 | 8,915,000 | 2,856,000 | 2,872,000 | 4,268,000 |
accrued liabilities | 1,034,170,000 | 1,001,556,000 | 874,811,000 | 1,063,918,000 | 910,947,000 | 858,578,000 | 800,993,000 | 826,530,000 | 793,914,000 | 769,942,000 | 748,304,000 | 712,349,000 | 803,255,000 | 668,390,000 | 593,207,000 | 604,710,000 | 666,304,000 | 603,715,000 | 561,091,000 | 374,035,000 | 352,732,000 | 302,071,000 | 266,918,000 | 261,041,000 | 267,873,000 | 238,740,000 | 218,751,000 | 292,390,000 | 264,887,000 | 257,453,000 | 258,794,000 | 240,544,000 | 198,779,000 | 179,890,000 | 169,701,000 | 183,645,000 | 193,268,000 | 172,418,000 | 157,622,000 | 307,504,000 | 164,070,000 | 166,375,000 | 146,053,000 | 146,975,000 | 164,091,000 | 161,476,000 | 142,843,000 | 147,737,000 | 119,718,000 | 106,390,000 | 96,771,000 | 100,935,000 | 104,666,000 | 123,632,000 | 125,080,000 | 74,566,000 | 34,783,000 | 35,834,000 | 26,713,000 | 23,274,000 | 23,572,000 | 19,075,000 | 16,217,000 | 15,368,000 | 14,296,000 | 21,370,000 | 22,147,000 | 21,401,000 | 19,024,000 | 23,161,000 | 31,252,000 | 30,133,000 | 29,047,000 | 23,892,000 | 22,198,000 |
current portion of long-term debt | 1,029,903,000 | 1,029,179,000 | 1,028,478,000 | 31,000,000 | 31,000,000 | 31,000,000 | 605,798,000 | 605,375,000 | 604,954,000 | 604,507,000 | 31,000,000 | 31,000,000 | 31,000,000 | 31,000,000 | 31,000,000 | 31,000,000 | 31,000,000 | 31,000,000 | 248,585,000 | 248,613,000 | 246,322,000 | 243,999,000 | 33,387,000 | 33,387,000 | 33,387,000 | 33,387,000 | 33,387,000 | 33,387,000 | 33,387,000 | 33,387,000 | 33,387,000 | 45,117,000 | 40,605,000 | 36,094,000 | 36,094,000 | 136,094,000 | 36,094,000 | 36,094,000 | 37,500,000 | 37,592,000 | 37,587,000 | 117,589,000 | 28,478,000 | 9,388,000 | 9,428,000 | 9,444,000 | 9,473,000 | 9,513,000 | 5,572,000 | 5,572,000 | 5,572,000 | 32,656,000 | 29,688,000 | 26,719,000 | 23,750,000 | 32,693,000 | 16,131,000 | 16,064,000 | 15,995,000 | 15,925,000 | |||||||||||||||
income taxes payable | 56,387,000 | 91,140,000 | 78,550,000 | 31,762,000 | 18,757,000 | 54,974,000 | 52,138,000 | 49,325,000 | 35,074,000 | 89,026,000 | 67,529,000 | 40,095,000 | 7,717,000 | 10,444,000 | 5,796,000 | 26,677,000 | 9,608,000 | 34,256,000 | 3,645,000 | 49,334,000 | 25,200,000 | 25,910,000 | 55,979,000 | 31,211,000 | 10,965,000 | 43,488,000 | 30,413,000 | 40,833,000 | 1,197,000 | 7,139,000 | 17,934,000 | 36,048,000 | 21,577,000 | 13,603,000 | 7,494,000 | 35,300,000 | 4,506,000 | 5,222,000 | 1,761,000 | 19,735,000 | 1,808,000 | 16,357,000 | 13,456,000 | 26,334,000 | 7,588,000 | 15,755,000 | 5,500,000 | 824,000 | 336,000 | 19,850,000 | 17,539,000 | 37,803,000 | 39,884,000 | ||||||||||||||||||||||
total current liabilities | 2,242,521,000 | 2,274,102,000 | 2,071,205,000 | 1,222,610,000 | 1,038,573,000 | 1,029,977,000 | 1,556,025,000 | 1,562,206,000 | 1,536,692,000 | 1,573,329,000 | 945,265,000 | 908,902,000 | 933,193,000 | 812,954,000 | 705,442,000 | 737,409,000 | 809,303,000 | 735,053,000 | 880,588,000 | 752,093,000 | 653,745,000 | 642,133,000 | 409,960,000 | 396,123,000 | 364,490,000 | 390,439,000 | 369,493,000 | 413,999,000 | 345,487,000 | 341,287,000 | 347,950,000 | 375,619,000 | 293,947,000 | 268,177,000 | 250,393,000 | 392,773,000 | 257,406,000 | 232,859,000 | 226,721,000 | 398,831,000 | 226,642,000 | 340,192,000 | 225,164,000 | 220,582,000 | 216,801,000 | 223,743,000 | 197,768,000 | 238,009,000 | 204,028,000 | 203,359,000 | 184,346,000 | 243,725,000 | 191,538,000 | 178,572,000 | 192,318,000 | 104,584,000 | 52,870,000 | 57,535,000 | 81,317,000 | 61,441,000 | 59,936,000 | 58,100,000 | 56,284,000 | 69,911,000 | 59,241,000 | 38,110,000 | 50,208,000 | 168,530,000 | 173,491,000 | 66,440,000 | 70,303,000 | 74,722,000 | 36,856,000 | 31,360,000 | 31,627,000 |
long-term debt, less current portion | 4,328,354,000 | 4,331,982,000 | 4,335,616,000 | 5,336,481,000 | 6,077,640,000 | 6,080,802,000 | 5,100,983,000 | 5,105,111,000 | 5,107,988,000 | 5,110,757,000 | 5,686,646,000 | 5,689,662,000 | 5,693,341,000 | 5,695,814,000 | 5,989,998,000 | 5,992,868,000 | 6,018,943,000 | 6,247,287,000 | 6,489,315,000 | 1,853,033,000 | 1,848,516,000 | 1,843,685,000 | 2,069,669,000 | 1,576,984,000 | 1,573,870,000 | 1,570,781,000 | 1,567,842,000 | 1,565,277,000 | 1,563,025,000 | 1,560,582,000 | 1,558,314,000 | 1,537,044,000 | 1,540,433,000 | 1,543,819,000 | 1,635,800,000 | 1,739,594,000 | 1,993,531,000 | 2,147,379,000 | 1,141,652,000 | 1,146,433,000 | 1,166,916,000 | 1,172,103,000 | 1,337,986,000 | 1,334,661,000 | 1,333,000,000 | 1,331,340,000 | 1,186,960,000 | 1,189,096,000 | 544,404,000 | 545,564,000 | 546,724,000 | 418,506,000 | 427,073,000 | 435,631,000 | 444,190,000 | 20,569,000 | 24,629,000 | 28,670,000 | 32,694,000 | ||||||||||||||||
operating lease liabilities, less current portion | 50,892,000 | 53,426,000 | 55,107,000 | 38,780,000 | 38,938,000 | 71,115,000 | 67,617,000 | 56,158,000 | 59,225,000 | 61,892,000 | 65,547,000 | 72,095,000 | 71,838,000 | 72,984,000 | 77,845,000 | 83,078,000 | 87,200,000 | 89,359,000 | 156,556,000 | 136,020,000 | 140,035,000 | 141,925,000 | 144,264,000 | 147,110,000 | 151,226,000 | 153,434,000 | 156,289,000 | 154,066,000 | |||||||||||||||||||||||||||||||||||||||||||||||
deferred tax liabilities | 594,470,000 | 629,033,000 | 682,123,000 | 670,801,000 | 676,736,000 | 791,784,000 | 775,228,000 | 809,714,000 | 847,706,000 | 841,234,000 | 910,724,000 | 932,247,000 | 944,337,000 | 933,670,000 | 1,096,416,000 | 1,222,084,000 | 1,300,541,000 | 1,329,184,000 | 1,421,027,000 | 109,915,000 | 130,397,000 | 141,588,000 | 162,376,000 | 165,095,000 | 224,095,000 | 250,167,000 | 283,669,000 | 296,148,000 | 309,097,000 | 337,021,000 | 354,932,000 | 382,072,000 | 383,472,000 | ||||||||||||||||||||||||||||||||||||||||||
other non-current liabilities | 124,519,000 | 108,912,000 | 93,731,000 | 91,119,000 | 86,614,000 | 110,971,000 | 99,416,000 | 97,425,000 | 104,751,000 | 127,480,000 | 126,683,000 | 109,178,000 | 106,812,000 | 123,935,000 | 129,420,000 | 124,644,000 | 116,998,000 | 137,806,000 | 132,507,000 | 105,868,000 | 101,148,000 | 142,475,000 | 134,839,000 | 117,258,000 | 109,374,000 | 102,583,000 | 120,713,000 | 111,897,000 | 218,879,000 | 208,647,000 | 205,731,000 | 192,181,000 | 176,608,000 | 158,497,000 | 144,690,000 | 128,809,000 | 112,617,000 | 106,101,000 | 94,196,000 | 79,207,000 | 69,253,000 | 59,666,000 | 52,664,000 | 45,122,000 | 38,393,000 | 33,596,000 | 29,175,000 | 25,395,000 | 20,040,000 | 16,747,000 | 13,330,000 | 9,817,000 | 6,621,000 | 2,161,000 | 1,615,000 | 1,314,000 | |||||||||||||||||||
commitments and contingencies | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shareholders’ equity: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, nominal value 0.0001 per share; 300,000 shares authorized; 61,435 and 60,631 shares issued and outstanding at december 31, 2025 and 2024, respectively | 6,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-voting euro deferred shares, €0.01 par value per share... | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
capital redemption reserve | 473,000 | 473,000 | 473,000 | 473,000 | 473,000 | 473,000 | 473,000 | 473,000 | 473,000 | 473,000 | 473,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 472,000 | 471,000 | 471,000 | 471,000 | 471,000 | 471,000 | 471,000 | 471,000 | 471,000 | 471,000 | 471,000 | 471,000 | 471,000 | 471,000 | 471,000 | 471,000 | 471,000 | |||||||||||||||||||
additional paid-in capital | 4,240,472,000 | 4,085,669,000 | 4,000,280,000 | 3,925,161,000 | 3,913,542,000 | 3,837,698,000 | 3,779,114,000 | 3,714,283,000 | 3,699,954,000 | 3,639,940,000 | 3,580,115,000 | 3,511,732,000 | 3,477,124,000 | 3,387,997,000 | 3,312,319,000 | 3,239,327,000 | 3,534,792,000 | 3,469,884,000 | 3,403,482,000 | 2,694,858,000 | 2,633,670,000 | 2,537,989,000 | 2,499,135,000 | 2,294,474,000 | 2,266,026,000 | 2,209,156,000 | 2,171,458,000 | 2,130,738,000 | 2,113,630,000 | 2,078,032,000 | 2,037,091,000 | 1,955,756,000 | 1,935,486,000 | 1,899,628,000 | 1,720,584,000 | 1,681,774,000 | 1,665,232,000 | 1,635,431,000 | 1,617,069,000 | 1,586,750,000 | 1,562,900,000 | 1,534,032,000 | 1,512,450,000 | 1,488,262,000 | 1,458,005,000 | 1,431,790,000 | 1,273,159,000 | 1,251,587,000 | 1,220,317,000 | 1,201,221,000 | 1,184,965,000 | 1,168,633,000 | 1,151,010,000 | 1,133,542,000 | 1,126,371,000 | 1,103,498,000 | 542,697,000 | 528,682,000 | 521,429,000 | 513,108,000 | 505,413,000 | 498,516,000 | 496,263,000 | 437,179,000 | 434,811,000 | 430,852,000 | 422,724,000 | 421,497,000 | 407,923,000 | 405,689,000 | 379,437,000 | 375,607,000 | 371,440,000 | 368,136,000 | 366,165,000 |
accumulated other comprehensive loss | -568,598,000 | -569,898,000 | -485,768,000 | -785,610,000 | -947,667,000 | -603,397,000 | -888,227,000 | -882,394,000 | -842,147,000 | -1,035,399,000 | -866,823,000 | -980,230,000 | -1,125,509,000 | -1,617,646,000 | -1,106,029,000 | -590,720,000 | -400,360,000 | -397,517,000 | -190,935,000 | -179,428,000 | -134,352,000 | -187,801,000 | -236,109,000 | -257,436,000 | -223,393,000 | -259,442,000 | -210,436,000 | -220,674,000 | -197,791,000 | -179,466,000 | -168,228,000 | -98,768,000 | -140,878,000 | -158,987,000 | -210,249,000 | -299,843,000 | -317,333,000 | -235,376,000 | -249,988,000 | -222,284,000 | -267,472,000 | -231,277,000 | -248,042,000 | -278,584,000 | -388,000 | -31,000 | -2,000 | ||||||||||||||||||||||||||||
retained earnings | 646,176,000 | 442,725,000 | 191,313,000 | 1,034,806,000 | 1,127,347,000 | 936,232,000 | 871,178,000 | 864,038,000 | 878,656,000 | 884,298,000 | 811,849,000 | 803,006,000 | 733,586,000 | 974,310,000 | 993,958,000 | 959,347,000 | 830,226,000 | 865,577,000 | 918,410,000 | 1,281,726,000 | 1,159,894,000 | 1,026,480,000 | 878,246,000 | 770,929,000 | 1,067,815,000 | 1,104,158,000 | 1,021,879,000 | 819,850,000 | 841,050,000 | 1,128,218,000 | 1,000,356,000 | 929,050,000 | 917,956,000 | 728,123,000 | 690,164,000 | 601,522,000 | 528,907,000 | 315,415,000 | 324,844,000 | 242,441,000 | 302,686,000 | 260,176,000 | 181,828,000 | 95,066,000 | 34,704,000 | -34,666,000 | -53,946,000 | -74,118,000 | 18,532,000 | ||||||||||||||||||||||||||
total shareholders’ equity | 4,318,584,000 | 3,959,030,000 | 3,706,359,000 | 4,174,891,000 | 4,093,756,000 | 4,171,067,000 | 3,762,599,000 | 3,696,461,000 | 3,736,997,000 | 3,489,373,000 | 3,525,675,000 | 3,335,041,000 | 3,085,734,000 | 2,745,194,000 | 3,200,781,000 | 3,608,487,000 | 3,965,191,000 | 3,938,477,000 | 4,131,490,000 | 3,797,689,000 | 3,659,745,000 | 3,377,201,000 | 3,141,805,000 | 2,808,500,000 | 3,110,981,000 | 3,054,405,000 | 2,983,434,000 | 2,730,447,000 | 2,757,422,000 | 3,027,317,000 | 2,869,752,000 | 2,786,571,000 | 2,713,097,000 | 2,469,297,000 | 2,201,032,000 | 1,983,986,000 | 1,877,339,000 | 1,716,003,000 | 1,692,458,000 | 1,607,440,000 | 1,598,646,000 | 1,563,477,000 | 1,446,823,000 | 1,305,330,000 | 1,371,208,000 | 1,340,613,000 | 1,280,087,000 | 1,295,534,000 | 1,243,701,000 | 1,175,453,000 | 1,161,900,000 | 1,121,292,000 | 886,087,000 | 831,459,000 | 781,832,000 | ||||||||||||||||||||
total liabilities and shareholders’ equity | 11,659,340,000 | 11,356,485,000 | 10,944,141,000 | 11,534,682,000 | 12,012,257,000 | 12,255,716,000 | 11,361,868,000 | 11,327,075,000 | 11,393,359,000 | 11,204,065,000 | 11,260,540,000 | 11,047,125,000 | 10,835,255,000 | 10,384,667,000 | 11,200,133,000 | 11,768,917,000 | 12,298,639,000 | 12,478,152,000 | 13,212,993,000 | 6,756,470,000 | 6,535,901,000 | 6,291,958,000 | 6,066,501,000 | 5,215,295,000 | 5,538,897,000 | 5,527,850,000 | 5,488,661,000 | 5,280,235,000 | 5,203,491,000 | 5,485,788,000 | 5,348,967,000 | 5,287,128,000 | 5,123,672,000 | 4,999,024,000 | 4,804,024,000 | 4,815,824,000 | 4,800,227,000 | 4,930,581,000 | 3,448,094,000 | 3,534,979,000 | 3,359,663,000 | 3,464,300,000 | 3,393,274,000 | 3,237,593,000 | 3,338,955,000 | 3,347,536,000 | 3,155,749,000 | 3,196,434,000 | 2,238,221,000 | 2,185,499,000 | 2,093,880,000 | 2,009,690,000 | 1,966,493,000 | 1,726,699,000 | 1,697,944,000 | 895,360,000 | |||||||||||||||||||
ordinary shares | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | 6,000 | |||||||||||||||||||||||||||||||||
non-voting euro deferred shares | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | 55,000 | |||||||||||||||||||||||||||||||||
ordinary shares, nominal value 0.0001 per share; 300,000 shares authorized; 60,631 and 62,255 shares issued and outstanding at december 31, 2024 and 2023, respectively | 6,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenue | 4,000 | 4,000 | 4,000 | 463,000 | 871,000 | 1,278,000 | 1,686,000 | 2,093,000 | 2,267,000 | 2,441,000 | 2,373,000 | 2,546,000 | 3,090,000 | 3,633,000 | 4,176,000 | 4,720,000 | 4,720,000 | 4,720,000 | 4,720,000 | 5,414,000 | 5,935,000 | 6,456,000 | 6,977,000 | 8,618,000 | 8,618,000 | 8,575,000 | 8,590,000 | 1,123,000 | 1,499,000 | 1,432,000 | 1,378,000 | 1,370,000 | 1,330,000 | 1,330,000 | 1,138,000 | 1,138,000 | 1,138,000 | 1,138,000 | 1,138,000 | 1,138,000 | 1,138,000 | 1,138,000 | 1,138,000 | 1,138,000 | 1,943,000 | 2,011,000 | 1,138,000 | 1,138,000 | 1,138,000 | 1,366,000 | 1,561,000 | 1,273,000 | 3,412,000 | 3,424,000 | 3,208,000 | 2,675,000 | 2,500,000 | 2,349,000 | 12,605,000 | 12,322,000 | 12,400,000 | 3,430,000 | 1,494,000 | 1,494,000 | 1,999,000 | 2,027,000 | |||||||||
ordinary shares, nominal value 0.0001 per share; 300,000 shares authorized; 62,255 and 63,214 shares issued and outstanding at december 31, 2023 and 2022, respectively | 6,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenue, non-current | 116,000 | 231,000 | 347,000 | 463,000 | 986,000 | 1,510,000 | 1,852,000 | 2,315,000 | 2,951,000 | 3,588,000 | 4,225,000 | 4,861,000 | 6,041,000 | 7,221,000 | 8,401,000 | 9,581,000 | 10,934,000 | 12,288,000 | 13,641,000 | 16,115,000 | 18,270,000 | 20,470,000 | 22,624,000 | 2,601,000 | 2,881,000 | 3,161,000 | 3,441,000 | 3,721,000 | 3,646,000 | 3,930,000 | 4,215,000 | 4,499,000 | 4,784,000 | 5,148,000 | 5,433,000 | 5,718,000 | 6,001,000 | 6,283,000 | 6,566,000 | 6,776,000 | 7,129,000 | 7,356,000 | 7,630,000 | 7,915,000 | 8,199,000 | 8,484,000 | 8,768,000 | 9,053,000 | 9,338,000 | 9,622,000 | 9,907,000 | 10,191,000 | 12,752,000 | 13,037,000 | |||||||||||||||||||||
ordinary shares, nominal value 0.0001 per share; 300,000 shares authorized; 63,214 and 61,633 shares issued and outstanding at december 31, 2022 and 2021, respectively | 6,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
assets held for sale | 90,888,000 | 78,033,000 | 32,833,000 | 59,546,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, nominal value 0.0001 per share; 300,000 shares authorized; 61,633 and 56,171 shares issued and outstanding at december 31, 2021 and 2020, respectively | 6,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, nominal value 0.0001 per share; 300,000 shares authorized; 56,171 and 56,140 shares issued and outstanding at december 31, 2020 and 2019, respectively | 6,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, nominal value 0.0001 per share; 300,000 shares authorized; 56,140 and 57,504 shares issued and outstanding at december 31, 2019 and 2018, respectively | 6,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, nominal value 0.0001 per share; 300,000 shares authorized; 57,504 and 59,898 shares issued and outstanding at december 31, 2018 and 2017, respectively | 6,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
property and equipment | 170,080,000 | 159,386,000 | 136,626,000 | 119,913,000 | 107,490,000 | 99,898,000 | 93,476,000 | 86,788,000 | 85,572,000 | 83,452,000 | 80,428,000 | 71,283,000 | 58,363,000 | 44,205,000 | 38,462,000 | 30,048,000 | 14,246,000 | 12,060,000 | 10,768,000 | 7,795,000 | 7,281,000 | 6,671,000 | 4,631,000 | 2,026,000 | 1,557,000 | 930,000 | 647,000 | 652,000 | 690,000 | 716,000 | 901,000 | 909,000 | 1,124,000 | 1,444,000 | 1,778,000 | 2,140,000 | 2,514,000 | 3,708,000 | 4,260,000 | 3,875,000 | 3,941,000 | 3,286,000 | 3,025,000 | ||||||||||||||||||||||||||||||||
ordinary shares, nominal value 0.0001 per share; 300,000 shares authorized; 59,898 and 59,820 shares issued and outstanding at december 31, 2017 and 2016, respectively | 6,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred tax assets, net, non-current | 23,662,000 | 20,158,000 | 18,038,000 | 15,060,000 | 117,507,000 | 122,036,000 | 122,863,000 | 76,391,000 | 73,280,000 | 74,185,000 | 75,494,000 | 101,249,000 | 96,495,000 | 94,250,000 | 74,597,000 | 70,976,000 | 65,136,000 | 62,933,000 | 74,850,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred tax liability, net, non-current | 540,964,000 | 551,639,000 | 548,038,000 | 556,733,000 | 725,358,000 | 289,906,000 | 299,627,000 | 294,485,000 | 325,216,000 | 326,707,000 | 327,683,000 | 375,054,000 | 413,460,000 | 456,611,000 | 471,993,000 | 168,497,000 | 170,127,000 | 167,744,000 | 169,176,000 | 178,393,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, nominal value 0.0001 per share; 300,000 shares authorized; 59,820 and 61,305 shares issued and outstanding at december 31, 2016 and 2015, respectively | 6,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred tax liability | 9,417,000 | 9,438,000 | 9,430,000 | 9,430,000 | 6,259,000 | 6,259,000 | 6,259,000 | 6,259,000 | 275,000 | 259,000 | 259,000 | 275,000 | 180,919,000 | 185,706,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, nominal value 0.0001 per share; 300,000 shares authorized; 61,305 and 60,643 shares issued and outstanding at december 31, 2015 and 2014, respectively | 6,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total jazz pharmaceuticals plc shareholders’ equity | 1,598,646,000 | 1,563,463,000 | 1,446,768,000 | 1,305,276,000 | 1,371,144,000 | 1,340,523,000 | 1,279,691,000 | 1,248,893,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncontrolling interests | 14,000 | 55,000 | 54,000 | 64,000 | 90,000 | 396,000 | 17,615,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
jazz pharmaceuticals plc shareholders' equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
contingent consideration | 50,000,000 | 47,700,000 | 42,700,000 | 39,300,000 | 34,800,000 | 36,200,000 | 35,300,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, nominal value 0.0001 per share; 300,000 shares authorized; 60,643 and 57,854 shares issued and outstanding at december 31, 2014 and 2013, respectively | 6,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive income | -122,097,000 | -57,133,000 | 59,946,000 | 70,892,000 | 56,153,000 | 44,622,000 | 19,220,000 | 10,606,000 | 31,046,000 | 13,860,000 | 3,000 | 4,000 | -3,000 | 12,000 | 19,000 | 1,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total shareholders' equity | 1,266,508,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
contingent consideration, non-current | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, nominal value 0.0001 per share; 300,000 shares authorized; 57,854 and 58,014 shares issued and outstanding at december 31, 2013 and 2012, respectively | 6,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated deficit | -2,674,000 | -29,264,000 | -17,871,000 | -61,296,000 | -261,847,000 | -295,056,000 | -322,201,000 | -349,882,000 | -387,355,000 | -419,837,000 | -453,039,000 | -474,866,000 | -499,325,000 | -512,568,000 | -506,180,000 | -507,644,000 | -513,297,000 | -511,625,000 | -513,796,000 | -500,808,000 | -443,868,000 | -415,058,000 | -363,179,000 | -316,469,000 | -256,449,000 | -237,090,000 | |||||||||||||||||||||||||||||||||||||||||||||||||
other long-term assets | 4,546,000 | 3,662,000 | 20,405,000 | 19,226,000 | 385,000 | 87,000 | 83,000 | 152,000 | 302,000 | 335,000 | 371,000 | 310,000 | 1,040,000 | 1,247,000 | 1,456,000 | 1,886,000 | 246,000 | 246,000 | 2,505,000 | 2,848,000 | 2,766,000 | 1,269,000 | 1,541,000 | 1,440,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||
marketable securities | 73,564,000 | 75,822,000 | 12,133,000 | 1,004,000 | 999,000 | 1,500,000 | 4,410,000 | 10,939,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchased product rights liability | 5,743,000 | 6,972,000 | 15,191,000 | 4,500,000 | 4,875,000 | 4,750,000 | 4,625,000 | 4,500,000 | 4,375,000 | 4,250,000 | 4,125,000 | 4,000,000 | 6,000,000 | 7,000,000 | 6,000,000 | 14,000,000 | 21,000,000 | 21,000,000 | 31,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability under government settlement | 7,320,000 | 7,225,000 | 7,130,000 | 8,202,000 | 4,128,000 | 4,002,000 | 2,715,000 | 2,594,000 | 2,954,000 | 10,658,000 | 13,063,000 | 13,063,000 | 13,063,000 | 13,063,000 | 14,881,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.0001 par value per share... | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ordinary shares, nominal value 0.0001 per share; 300,000 and 150,000 shares authorized; 58,014 and 42,468 shares issued and outstanding at december 31, 2012 and 2011, respectively | 6,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restricted cash | 400,000 | 400,000 | 400,000 | 910,000 | 951,000 | 2,988,000 | 950,000 | 1,075,000 | 775,000 | 1,913,000 | 1,998,000 | 1,998,000 | 1,998,000 | 1,939,000 | 304,000 | 275,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities and stockholders’ equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
revolving credit facility | 4,000,000 | 4,000,000 | 7,350,000 | 7,350,000 | 7,350,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchased product rights liability, non-current | 750,000 | 2,000,000 | 3,250,000 | 4,500,000 | 5,625,000 | 6,750,000 | 7,875,000 | 9,000,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability under government settlement, non-current | 6,978,000 | 6,978,000 | 8,142,000 | 8,142,000 | 10,658,000 | 14,881,000 | 14,881,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred rent | 12,000 | 77,000 | 82,000 | 86,000 | 73,000 | 51,000 | 29,000 | 7,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ equity: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.0001 par value... | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
common stock, 0.0001 par value... | 4,000 | 4,000 | 3,000 | 3,000 | 2,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total stockholders’ equity | 192,788,000 | 141,329,000 | 101,596,000 | 60,073,000 | 30,551,000 | -92,878,000 | -38,179,000 | -35,619,000 | 12,442,000 | 54,992,000 | 111,690,000 | 129,077,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities and stockholders’ equity | 253,573,000 | 207,813,000 | 193,409,000 | 154,178,000 | 135,729,000 | 117,498,000 | 179,793,000 | 186,591,000 | 239,018,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
common stock | 4,000 | 4,000 | 4,000 | 4,000 | 4,000 | 3,000 | 3,000 | 3,000 | 3,000 | 3,000 | 2,000 | 2,000 | 2,000 | 2,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities and stockholders’ deficit | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ deficit: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total stockholders’ deficit | -805,000 | -16,301,000 | -68,998,000 | -72,830,000 | -82,442,000 | -88,898,000 | -92,296,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities and stockholders’ deficit | 107,992,000 | 97,264,000 | 106,706,000 | 107,396,000 | 102,172,000 | 108,574,000 | 109,937,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
line of credit | 7,840,000 | 9,399,000 | 3,000,000 | 3,875,000 | 3,265,000 | 6,099,000 | 3,180,000 | 3,459,000 | 2,597,000 | 3,134,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
senior secured notes | 32,891,000 | 23,759,000 | 14,638,000 | 123,970,000 | 118,534,000 | 113,614,000 | 113,704,000 | 113,367,000 | 75,116,000 | 74,862,000 | 74,622,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
common stock subject to repurchase | 12,492,000 | 13,241,000 | 13,241,000 | 13,241,000 | 13,241,000 | 13,222,000 | 13,174,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchased product rights liability, noncurrent | 10,000,000 | 11,000,000 | 12,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenue, noncurrent | 10,476,000 | 10,761,000 | 11,045,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability under government settlement, noncurrent | 10,658,000 | 10,658,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term restricted cash and investments | 12,000,000 | 12,085,000 | 12,085,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-current portion of deferred revenue | 11,330,000 | 11,614,000 | 11,899,000 | 12,183,000 | 12,468,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities, convertible preferred stock, and stockholders’ equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock warrant liability | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability for early exercise of options and unvested restricted common stock | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible preferred stock, 0.0001 par value... | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities, convertible preferred stock and stockholders’ equity | 207,554,000 | 258,767,000 | 276,870,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities, convertible preferred stock and stockholders’ equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred rent and other non-current liabilities | 452,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
convertible preferred stock |
Cashflow Statements:
Quarterly
Annual
| Unit: USD | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-12-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-12-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-12-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 | 2013-12-31 | 2013-09-30 | 2013-06-30 | 2013-03-31 | 2012-12-31 | 2012-09-30 | 2012-06-30 | 2012-03-31 | 2011-12-31 | 2011-09-30 | 2011-06-30 | 2011-03-31 | 2010-12-31 | 2010-09-30 | 2010-06-30 | 2010-03-31 | 2009-12-31 | 2009-09-30 | 2009-06-30 | 2009-03-31 | 2008-12-31 | 2008-09-30 | 2008-06-30 | 2008-03-31 | 2007-12-31 | 2007-09-30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
operating activities | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income | 203,451,000 | 251,412,000 | 191,115,000 | 215,055,000 | 168,568,000 | -14,618,000 | 94,154,000 | 146,820,000 | 104,438,000 | 69,420,000 | -240,724,000 | -19,648,000 | 34,665,000 | 1,647,000 | -35,351,000 | 121,832,000 | 133,414,000 | 148,234,000 | 114,801,000 | -157,833,000 | 73,992,000 | 102,276,000 | 261,898,000 | 85,201,000 | 159,470,000 | 149,316,000 | 92,321,000 | 45,991,000 | 232,207,000 | 63,526,000 | 105,604,000 | 86,511,000 | 124,283,000 | 87,145,000 | 111,282,000 | 74,121,000 | 82,761,000 | 87,960,000 | 88,113,000 | 70,700,000 | 81,611,000 | 25,768,000 | 43,586,000 | -93,639,000 | 55,293,000 | 75,409,000 | 42,185,000 | 43,425,000 | 200,551,000 | 33,209,000 | 27,145,000 | 27,681,000 | 37,473,000 | 32,482,000 | 33,202,000 | 21,827,000 | 24,459,000 | 1,464,000 | ||||||||||||||||
adjustments to reconcile net income to net cash from operating activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
acquired in-process research and development | 0 | 42,500,000 | 0 | 0 | 0 | 10,000,000 | 18,000,000 | 0 | 0 | 1,000,000 | 375,000,000 | 0 | 36,000,000 | 10,000,000 | 3,000,000 | 202,250,000 | 0 | 51,775,000 | 2,200,000 | 56,000,000 | 8,000,000 | 75,000,000 | 0 | 15,000,000 | 0 | 8,750,000 | 626,000 | 75,000,000 | 0 | 127,000,000 | ||||||||||||||||||||||||||||||||||||||||||||
intangible asset amortization | 169,742,000 | 168,368,000 | 162,103,000 | 154,448,000 | 158,903,000 | 157,457,000 | 155,223,000 | 155,730,000 | 151,553,000 | 154,883,000 | 152,062,000 | 149,786,000 | 137,387,000 | 141,232,000 | 148,456,000 | 172,094,000 | 157,293,000 | 159,804,000 | 140,480,000 | 68,192,000 | 67,075,000 | 66,684,000 | 62,974,000 | 62,847,000 | 173,490,000 | 62,863,000 | 61,576,000 | 56,885,000 | 46,543,000 | 46,989,000 | 54,959,000 | 53,007,000 | 52,901,000 | 47,313,000 | 26,186,000 | 25,665,000 | 26,162,000 | 26,453,000 | 26,737,000 | 22,642,000 | 23,690,000 | 26,127,000 | 23,668,000 | 24,677,000 | ||||||||||||||||||||||||||||||
share-based compensation | 70,854,000 | 88,125,000 | 64,501,000 | 67,653,000 | 70,190,000 | 59,760,000 | 56,654,000 | 61,441,000 | 52,941,000 | 56,115,000 | 61,433,000 | 56,352,000 | 61,558,000 | 56,681,000 | 53,687,000 | 50,070,000 | 53,119,000 | 53,239,000 | 48,163,000 | 34,485,000 | 31,384,000 | 30,356,000 | 30,604,000 | 28,654,000 | 25,937,000 | 28,785,000 | 28,289,000 | 27,552,000 | 26,723,000 | 25,103,000 | 26,312,000 | 24,303,000 | 27,321,000 | 27,126,000 | 27,260,000 | 25,193,000 | 24,281,000 | 24,874,000 | 25,433,000 | 24,183,000 | 24,317,000 | 23,114,000 | 23,300,000 | 20,819,000 | 19,020,000 | 18,251,000 | 18,552,000 | 13,815,000 | 12,412,000 | 11,876,000 | 11,506,000 | 8,757,000 | ||||||||||||||||||||||
acquisition accounting inventory fair value step-up adjustment | 40,604,000 | 40,355,000 | 37,109,000 | 29,880,000 | 37,794,000 | 35,034,000 | 33,243,000 | 28,943,000 | 32,352,000 | 30,822,000 | 27,814,000 | 60,458,000 | 70,203,000 | 70,964,000 | 68,282,000 | 63,943,000 | 74,448,000 | 82,646,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
depreciation | 9,427,000 | 9,878,000 | 11,906,000 | 10,425,000 | 9,514,000 | 7,775,000 | 7,812,000 | 7,653,000 | 7,648,000 | 7,675,000 | 7,515,000 | 7,574,000 | 7,344,000 | 7,594,000 | 7,747,000 | 7,617,000 | 7,327,000 | 7,773,000 | 6,835,000 | 4,779,000 | 4,597,000 | 4,810,000 | 4,739,000 | 4,527,000 | 4,457,000 | 3,991,000 | 3,355,000 | 3,539,000 | 3,870,000 | 3,906,000 | 3,735,000 | 3,722,000 | 3,801,000 | 3,065,000 | 3,093,000 | 3,130,000 | 3,621,000 | 3,121,000 | 2,517,000 | 2,527,000 | 2,751,000 | 2,548,000 | 2,363,000 | 2,232,000 | 2,060,000 | 1,868,000 | 1,860,000 | 1,309,000 | 983,000 | 895,000 | 595,000 | 575,000 | 518,000 | 374,000 | 229,000 | 186,000 | 111,000 | 79,000 | 85,000 | 104,000 | 173,000 | 188,000 | 224,000 | 301,000 | 326,000 | 364,000 | 369,000 | 370,000 | 438,000 | 609,000 | 627,000 | 524,000 | ||
non-cash interest expense | 5,329,000 | 5,299,000 | 4,848,000 | 17,066,000 | 3,096,000 | 7,677,000 | 5,212,000 | 5,988,000 | 6,123,000 | 6,062,000 | 5,427,000 | 4,766,000 | 5,971,000 | 14,262,000 | 5,572,000 | 12,168,000 | 26,600,000 | 28,045,000 | 535,000 | 625,000 | 592,000 | 513,000 | 330,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||
provision for losses on accounts receivable and inventory | 4,114,000 | 8,223,000 | 1,452,000 | 5,319,000 | 11,892,000 | 2,680,000 | 5,783,000 | 7,403,000 | 3,381,000 | 2,182,000 | 3,234,000 | 2,316,000 | 1,471,000 | 6,916,000 | 3,980,000 | 2,170,000 | 6,224,000 | 4,702,000 | 7,659,000 | 1,083,000 | 5,852,000 | 5,070,000 | 1,458,000 | 2,620,000 | 2,821,000 | 1,444,000 | 1,875,000 | 528,000 | -6,000 | 2,064,000 | 2,080,000 | 590,000 | 365,000 | 277,000 | 600,000 | 948,000 | 445,000 | 76,000 | 790,000 | 898,000 | 41,000 | 3,411,000 | 184,000 | 426,000 | -380,000 | 948,000 | 1,112,000 | 813,000 | 688,000 | 522,000 | 1,094,000 | 142,000 | 1,958,000 | |||||||||||||||||||||
deferred tax benefit | -63,309,000 | -271,410,000 | -66,419,000 | -43,833,000 | -2,355,000 | -64,404,000 | -75,183,000 | -66,385,000 | -78,922,000 | -79,334,000 | -66,061,000 | -45,339,000 | -19,110,000 | -16,028,000 | -38,141,000 | -18,792,000 | -63,976,000 | -68,675,000 | -16,588,000 | -134,294,000 | -17,053,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
impairment of property, plant and equipment | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other non-cash transactions | -4,955,000 | 1,016,000 | 13,579,000 | -6,537,000 | -1,637,000 | 4,095,000 | 846,000 | 14,674,000 | -42,919,000 | 6,106,000 | 31,383,000 | 16,773,000 | 11,866,000 | 2,743,000 | -14,394,000 | -14,701,000 | 410,000 | 6,639,000 | -4,783,000 | 7,766,000 | 1,908,000 | 9,176,000 | 1,594,000 | 1,902,000 | 386,000 | -1,890,000 | -3,728,000 | 1,181,000 | -2,471,000 | -4,026,000 | -5,030,000 | 16,026,000 | -159,000 | 6,480,000 | 6,595,000 | 1,405,000 | -5,201,000 | 493,000 | -612,000 | 1,579,000 | -1,353,000 | -11,772,000 | 7,306,000 | 632,000 | 1,518,000 | -2,686,000 | 1,039,000 | 1,868,000 | 1,843,000 | 1,184,000 | 1,276,000 | 1,975,000 | 1,752,000 | 1,462,000 | -2,102,000 | 2,411,000 | ||||||||||||||||||
changes in assets and liabilities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts receivable | -65,813,000 | -50,996,000 | -55,519,000 | 66,049,000 | 864,000 | -22,256,000 | 8,720,000 | -8,443,000 | -75,464,000 | -18,858,000 | 13,979,000 | 28,460,000 | -46,267,000 | -9,637,000 | -24,508,000 | -9,723,000 | -64,779,000 | 6,882,000 | -16,593,000 | -18,245,000 | -33,643,000 | -8,644,000 | -34,221,000 | 37,861,000 | -88,019,000 | 43,267,000 | 9,386,000 | -56,960,000 | 15,386,000 | -1,162,000 | 2,235,000 | -56,591,000 | 34,551,000 | -19,235,000 | 5,445,000 | -8,483,000 | 2,671,000 | -6,116,000 | -8,356,000 | -13,802,000 | -14,180,000 | -2,182,000 | -3,710,000 | -4,769,000 | -4,351,000 | -28,801,000 | -5,875,000 | -16,014,000 | -11,197,000 | 1,366,000 | -20,104,000 | -18,911,000 | 13,049,000 | -10,346,000 | 1,367,000 | -8,794,000 | -2,946,000 | -6,429,000 | -3,616,000 | 698,000 | -7,967,000 | -19,000 | -2,140,000 | 358,000 | -3,111,000 | -5,000 | -2,185,000 | -369,000 | 43,000 | -1,465,000 | 89,000 | 79,000 | 927,000 | -104,000 |
inventories | 7,720,000 | -31,909,000 | -26,231,000 | -35,621,000 | -18,665,000 | -9,286,000 | -4,747,000 | -12,844,000 | -1,404,000 | -4,934,000 | -816,000 | -6,266,000 | 816,000 | -8,529,000 | -17,117,000 | -24,812,000 | -14,970,000 | -4,489,000 | -7,388,000 | -22,014,000 | -8,676,000 | -3,035,000 | -8,591,000 | -10,235,000 | -9,762,000 | -4,466,000 | -9,874,000 | -8,688,000 | -10,929,000 | 1,355,000 | -5,626,000 | -3,312,000 | -1,535,000 | -1,253,000 | -1,621,000 | -4,258,000 | -2,907,000 | 933,000 | -8,743,000 | -6,307,000 | 9,866,000 | -1,746,000 | -7,000 | -1,842,000 | 2,554,000 | -6,882,000 | -231,000 | -3,071,000 | -5,071,000 | 2,659,000 | -7,335,000 | 1,231,000 | -18,000 | 909,000 | 864,000 | -58,000 | 506,000 | 440,000 | 302,000 | 50,000 | -613,000 | -49,000 | -911,000 | -71,000 | 631,000 | -329,000 | 223,000 | 358,000 | 1,450,000 | -56,000 | -4,038,000 | 10,000 | 1,026,000 | -2,000 |
prepaid expenses and other assets | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts payable | -28,972,000 | 62,358,000 | -12,666,000 | 19,131,000 | -3,135,000 | -12,790,000 | 15,449,000 | -19,597,000 | -8,102,000 | 10,243,000 | -26,824,000 | 34,286,000 | -15,413,000 | 28,959,000 | 2,846,000 | -27,617,000 | 37,854,000 | -142,000 | -31,983,000 | 51,292,000 | -39,580,000 | 15,381,000 | -14,340,000 | 19,604,000 | -24,334,000 | 43,200,000 | -15,650,000 | 1,554,000 | 6,924,000 | 2,745,000 | -15,765,000 | 23,136,000 | -5,916,000 | 783,000 | -518,000 | 5,865,000 | 4,649,000 | -10,512,000 | -4,440,000 | 10,664,000 | -7,106,000 | 2,697,000 | -1,174,000 | 3,303,000 | -4,101,000 | -2,310,000 | -40,134,000 | 8,579,000 | -1,581,000 | 1,963,000 | -11,451,000 | 16,158,000 | -4,743,000 | -13,906,000 | 6,714,000 | 4,649,000 | -3,334,000 | 3,798,000 | 1,017,000 | 599,000 | -842,000 | -2,512,000 | 2,518,000 | 1,727,000 | -3,082,000 | 1,166,000 | -480,000 | -1,182,000 | -878,000 | -1,908,000 | -393,000 | 6,059,000 | -16,000 | -1,036,000 |
accrued liabilities | 26,170,000 | 126,277,000 | -256,389,000 | 181,038,000 | 29,731,000 | 51,024,000 | -29,273,000 | 34,677,000 | 53,016,000 | 13,547,000 | 7,177,000 | -96,985,000 | 148,127,000 | 62,294,000 | -21,189,000 | -23,241,000 | 48,821,000 | 36,846,000 | 42,969,000 | 13,719,000 | 52,967,000 | 33,482,000 | 5,226,000 | -12,198,000 | 31,804,000 | 21,662,000 | -56,346,000 | -2,685,000 | 6,134,000 | 4,966,000 | 12,624,000 | 47,484,000 | 17,005,000 | 9,489,000 | -17,329,000 | -15,743,000 | 19,781,000 | -4,058,000 | 1,117,000 | -6,706,000 | -1,656,000 | 22,777,000 | -650,000 | -17,485,000 | 1,529,000 | 20,289,000 | -1,748,000 | 927,000 | 13,155,000 | 9,311,000 | -5,089,000 | -2,660,000 | -13,970,000 | -4,012,000 | 22,878,000 | -6,539,000 | -1,051,000 | 9,121,000 | 3,439,000 | -298,000 | 4,497,000 | 3,171,000 | 536,000 | 1,072,000 | 2,707,000 | -5,409,000 | 597,000 | -90,000 | -655,000 | -7,947,000 | 2,753,000 | 476,000 | 5,501,000 | 1,820,000 |
income taxes payable | -34,784,000 | 12,738,000 | 46,282,000 | 12,988,000 | -34,840,000 | 2,068,000 | 3,172,000 | 14,858,000 | -35,939,000 | 15,222,000 | 20,524,000 | 25,413,000 | -1,520,000 | 4,296,000 | -21,235,000 | 16,767,000 | -24,695,000 | 31,010,000 | -46,464,000 | 24,625,000 | -2,051,000 | -30,392,000 | 24,652,000 | 20,829,000 | -32,757,000 | 13,763,000 | -10,676,000 | 39,726,000 | -5,736,000 | -10,714,000 | -17,468,000 | 14,183,000 | 7,836,000 | 6,008,000 | -28,266,000 | 30,753,000 | -361,000 | -75,000 | -22,360,000 | 25,758,000 | -15,264,000 | 2,496,000 | -23,666,000 | 30,163,000 | -10,369,000 | 13,549,000 | -303,000 | 5,757,000 | -19,898,000 | 2,812,000 | -20,501,000 | -1,397,000 | ||||||||||||||||||||||
other liabilities | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash from operating activities | 362,518,000 | 474,616,000 | 88,855,000 | 429,784,000 | 398,580,000 | 398,747,000 | 331,352,000 | 267,229,000 | 167,339,000 | 307,195,000 | 296,765,000 | 320,708,000 | 341,971,000 | 417,991,000 | 303,036,000 | 208,979,000 | 177,755,000 | 274,060,000 | 41,695,000 | 284,997,000 | 186,271,000 | 257,889,000 | 182,519,000 | 272,969,000 | 87,798,000 | 337,503,000 | 148,847,000 | 202,253,000 | 224,346,000 | 220,575,000 | 191,624,000 | 162,359,000 | 204,559,000 | 188,897,000 | 135,091,000 | 164,540,000 | 180,695,000 | 136,531,000 | 129,594,000 | 143,716,000 | 119,741,000 | 175,076,000 | 140,571,000 | 96,555,000 | 132,421,000 | 129,697,000 | 74,924,000 | 68,723,000 | 79,207,000 | 129,800,000 | 8,719,000 | 65,890,000 | 104,345,000 | 44,143,000 | 76,969,000 | 24,295,000 | 43,659,000 | 46,053,000 | 37,436,000 | 24,448,000 | 31,275,000 | 18,486,000 | 2,607,000 | 6,500,000 | 1,772,000 | -11,442,000 | -1,058,000 | -5,150,000 | -18,786,000 | -28,689,000 | -44,587,000 | -38,170,000 | -28,061,000 | -15,371,000 |
capital expenditures | -16,729,000 | -15,175,000 | -12,967,000 | -13,881,000 | -13,287,000 | -10,788,000 | -7,091,000 | -6,904,000 | -10,102,000 | -4,299,000 | -5,739,000 | -3,822,000 | -9,378,000 | 4,902,000 | -12,278,000 | -12,292,000 | -9,967,000 | -8,328,000 | -7,178,000 | -2,168,000 | -4,115,000 | -3,369,000 | -2,690,000 | -4,830,000 | -7,137,000 | -11,087,000 | -13,963,000 | -7,948,000 | -5,149,000 | -3,940,000 | -4,132,000 | -7,149,000 | -8,878,000 | -8,347,000 | -8,151,000 | -3,574,000 | -1,277,000 | -2,382,000 | -1,701,000 | -2,472,000 | -3,367,000 | -5,159,000 | -13,022,000 | -14,410,000 | -13,548,000 | -8,139,000 | -11,133,000 | -3,527,000 | -3,102,000 | -2,164,000 | -3,567,000 | -1,143,000 | -983,000 | -2,499,000 | -2,209,000 | -285,000 | -756,000 | -362,000 | -95,000 | -66,000 | -113,000 | -316,000 | -216,000 | -86,000 | -6,000 | -30,000 | -12,000 | -5,000 | -74,000 | -56,000 | -1,151,000 | -458,000 | -1,043,000 | -593,000 |
free cash flows | 345,789,000 | 459,441,000 | 75,888,000 | 415,903,000 | 385,293,000 | 387,959,000 | 324,261,000 | 260,325,000 | 157,237,000 | 302,896,000 | 291,026,000 | 316,886,000 | 332,593,000 | 422,893,000 | 290,758,000 | 196,687,000 | 167,788,000 | 265,732,000 | 34,517,000 | 282,829,000 | 182,156,000 | 254,520,000 | 179,829,000 | 268,139,000 | 80,661,000 | 326,416,000 | 134,884,000 | 194,305,000 | 219,197,000 | 216,635,000 | 187,492,000 | 155,210,000 | 195,681,000 | 180,550,000 | 126,940,000 | 160,966,000 | 179,418,000 | 134,149,000 | 127,893,000 | 141,244,000 | 116,374,000 | 169,917,000 | 127,549,000 | 82,145,000 | 118,873,000 | 121,558,000 | 63,791,000 | 65,196,000 | 76,105,000 | 127,636,000 | 5,152,000 | 64,747,000 | 103,362,000 | 41,644,000 | 74,760,000 | 24,010,000 | 42,903,000 | 45,691,000 | 37,341,000 | 24,382,000 | 31,162,000 | 18,170,000 | 2,391,000 | 6,414,000 | 1,766,000 | -11,472,000 | -1,070,000 | -5,155,000 | -18,860,000 | -28,745,000 | -45,738,000 | -38,628,000 | -29,104,000 | -15,964,000 |
investing activities | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
acquisition of investments | -510,100,000 | -640,125,000 | -240,000,000 | -440,050,000 | -470,000,000 | -130,125,000 | -330,000,000 | -375,000,000 | -120,100,000 | -190,000,000 | 0 | -300,000 | -125,000 | -594,000 | -5,400,000 | -20,700,000 | -735,925,000 | -621,275,000 | -855,475,000 | -185,000,000 | -331,125,000 | -225,000,000 | -245,975,000 | -115,000,000 | -250,915,000 | -415,000,000 | -265,000,000 | -235,000,000 | -95,000,000 | -270,000,000 | -582,000 | -11,209,000 | -52,711,000 | -773,000 | ||||||||||||||||||||||||||||||||||||||||
asset acquisition, net of cash acquired | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
acquisition of intangible assets | -53,500,000 | -30,000,000 | 0 | -25,000,000 | 0 | 0 | 0 | -25,000,000 | 0 | 0 | 0 | -100,000,000 | -13,000,000 | 0 | -55,000,000 | 0 | 2,000 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of property, plant and equipment | -16,729,000 | -15,175,000 | -12,967,000 | -13,881,000 | -13,287,000 | -10,788,000 | -7,091,000 | -6,904,000 | -10,102,000 | -4,299,000 | -5,739,000 | -3,822,000 | -9,378,000 | 4,902,000 | -12,278,000 | -12,292,000 | -9,967,000 | -8,328,000 | -7,178,000 | -2,168,000 | -4,115,000 | -3,369,000 | -2,690,000 | -4,830,000 | -7,137,000 | -11,087,000 | -13,963,000 | -7,948,000 | -5,149,000 | -3,940,000 | -4,132,000 | -7,149,000 | ||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of an asset | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from maturity of investments | 180,000,000 | 400,000,000 | 470,000,000 | 310,000,000 | 290,000,000 | 355,000,000 | 80,000,000 | 120,000,000 | 250,000,000 | 0 | 0 | 335,000,000 | 760,000,000 | 835,000,000 | 355,000,000 | 220,000,000 | 345,000,000 | 165,000,000 | 190,000,000 | 285,000,000 | 345,000,000 | 290,000,000 | 180,000,000 | 190,000,000 | 195,000,000 | 80,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
net cash from investing activities | -372,162,000 | -327,800,000 | -641,020,000 | -168,931,000 | -193,287,000 | 214,087,000 | -257,091,000 | -271,904,000 | 101,798,000 | -174,299,000 | -85,739,000 | -4,822,000 | -324,378,000 | 4,602,000 | -89,162,000 | -37,292,000 | -10,092,000 | -26,813,000 | -5,912,370,000 | 737,132,000 | 73,219,000 | -279,644,000 | -741,165,000 | -60,080,000 | -159,053,000 | -159,661,000 | -2,638,000 | 166,052,000 | 33,742,000 | -190,846,000 | -190,234,000 | -47,149,000 | -31,878,000 | -203,347,000 | -30,151,000 | -3,574,000 | -1,859,000 | -1,531,034,000 | -204,412,000 | -11,995,000 | -3,367,000 | -5,159,000 | -12,022,000 | 18,293,000 | -14,174,000 | -83,139,000 | -13,133,000 | -957,203,000 | -3,102,000 | -2,164,000 | -3,567,000 | -2,443,000 | 87,189,000 | -3,749,000 | -561,242,000 | 82,508,000 | -65,599,000 | -13,622,000 | -820,000 | -1,191,000 | -1,113,000 | -806,000 | -1,175,000 | 951,000 | -5,044,000 | -1,905,000 | -312,000 | 1,137,000 | -6,994,000 | 6,220,000 | -8,241,000 | -2,927,000 | 9,405,000 | -11,470,000 |
financing activities | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repayments of long-term debt | -7,750,000 | -7,750,000 | -7,750,000 | -757,750,000 | -7,750,000 | -7,750,000 | -7,750,000 | -7,750,000 | -7,750,000 | -7,750,000 | -7,750,000 | -7,750,000 | -7,750,000 | -307,746,000 | -7,754,000 | -258,764,000 | -258,760,000 | -258,760,000 | -575,921,000 | -8,347,000 | -8,347,000 | -8,347,000 | -8,346,000 | -8,347,000 | -8,347,000 | -8,347,000 | -8,346,000 | -8,347,000 | -8,347,000 | -8,347,000 | 0 | -9,023,000 | -9,024,000 | -9,023,000 | -9,024,000 | -9,023,000 | -9,022,000 | 0 | -9,885,000 | -9,397,000 | -9,397,000 | -961,000 | -893,118,000 | -2,284,000 | -2,434,000 | |||||||||||||||||||||||||||||
share repurchases | 0 | 0 | 0 | -150,001,000 | -99,795,000 | -74,371,000 | 0 | 0 | 0 | 0 | -7,484,000 | -139,053,000 | -110,335,000 | -19,997,000 | -59,869,000 | -111,249,000 | -446,657,000 | -21,454,000 | -21,015,000 | -34,546,000 | -42,374,000 | -25,566,000 | -16,963,000 | -13,896,000 | -18,477,000 | -96,575,000 | -28,879,000 | -134,365,000 | -40,251,000 | -9,612,000 | -1,352,000 | -10,338,000 | -12,242,000 | -6,486,000 | -34,087,000 | -48,819,000 | ||||||||||||||||||||||||||||||||||||||
payment of employee withholding taxes related to share-based awards | -1,996,000 | -3,812,000 | -2,249,000 | -67,163,000 | -4,005,000 | -1,605,000 | -2,847,000 | -49,296,000 | -1,614,000 | -1,884,000 | -4,188,000 | -43,266,000 | -2,811,000 | -2,567,000 | -6,289,000 | -33,776,000 | -5,999,000 | -2,431,000 | -3,388,000 | -23,784,000 | -1,117,000 | -1,097,000 | -1,116,000 | -13,547,000 | -839,000 | -1,087,000 | -1,003,000 | -13,810,000 | -733,000 | -1,169,000 | -1,429,000 | -14,594,000 | -680,000 | -1,589,000 | -1,889,000 | -14,431,000 | -639,000 | -6,317,000 | -1,802,000 | -12,476,000 | -700,000 | -8,723,000 | -1,901,000 | -14,778,000 | -724,000 | -6,755,000 | -1,188,000 | -9,363,000 | -287,000 | -3,706,000 | -170,000 | -1,427,000 | ||||||||||||||||||||||
proceeds from employee equity incentive and purchase plans | 85,186,000 | 733,000 | 10,497,000 | 11,447,000 | 9,196,000 | 17,000 | 10,940,000 | 494,000 | 8,853,000 | 5,512,000 | 10,866,000 | 21,228,000 | 30,157,000 | 21,260,000 | 24,874,000 | 21,729,000 | 18,150,000 | 14,822,000 | 51,882,000 | 50,407,000 | 65,342,000 | 10,088,000 | 10,987,000 | 13,264,000 | 31,741,000 | 9,968,000 | 13,065,000 | 3,057,000 | 9,281,000 | 16,998,000 | 56,470,000 | 10,588,000 | 9,031,000 | 3,722,000 | 3,340,000 | |||||||||||||||||||||||||||||||||||||||
repayment of 2024 notes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payment of debt modification costs | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net proceeds from issuance of 2030 notes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net cash from financing activities | 75,440,000 | -10,829,000 | -124,525,000 | -813,466,000 | -8,275,000 | 246,428,000 | -161,085,000 | -56,552,000 | -100,306,000 | -78,493,000 | -96,667,000 | -29,788,000 | 19,596,000 | -289,053,000 | 10,777,000 | -270,811,000 | -246,609,000 | -465,181,000 | 4,664,036,000 | 18,276,000 | 55,878,000 | -22,656,000 | 642,534,000 | -147,683,000 | -87,780,000 | -19,463,000 | -56,153,000 | -130,349,000 | -446,456,000 | -13,972,000 | 28,873,000 | -47,575,000 | -39,984,000 | 27,028,000 | -214,481,000 | -181,674,000 | -172,045,000 | 891,722,000 | -34,170,000 | -144,520,000 | -123,861,000 | -94,424,000 | 7,223,000 | -3,261,000 | -8,599,000 | 263,267,000 | -39,455,000 | 497,662,000 | -28,896,000 | -45,722,000 | 47,456,000 | 3,133,000 | 3,590,000 | -5,488,000 | 468,653,000 | -18,225,000 | 2,801,000 | -33,612,000 | 719,000 | -2,990,000 | -8,221,000 | -4,401,000 | -10,856,000 | -4,048,000 | 6,637,000 | 9,805,000 | 127,000 | -3,875,000 | 776,000 | 21,174,000 | 3,259,000 | 38,923,000 | 1,629,000 | -1,187,000 |
effect of exchange rates on cash and cash equivalents | 33,000 | 203,000 | 4,624,000 | 1,695,000 | -2,289,000 | 3,071,000 | -759,000 | -1,698,000 | 1,789,000 | -1,017,000 | 34,000 | 331,000 | 4,935,000 | -5,447,000 | -4,221,000 | -1,489,000 | -1,386,000 | -1,686,000 | 506,000 | -641,000 | 459,000 | 271,000 | 592,000 | -948,000 | 1,204,000 | -943,000 | 217,000 | -112,000 | -1,028,000 | -1,820,000 | 1,649,000 | -501,000 | 723,000 | 824,000 | 1,759,000 | 1,740,000 | -7,395,000 | 1,382,000 | -2,826,000 | 3,794,000 | -2,587,000 | 1,723,000 | 3,268,000 | -13,026,000 | -646,000 | -3,040,000 | 45,000 | 188,000 | 833,000 | 2,241,000 | 1,188,000 | -3,265,000 | 2,279,000 | 344,000 | ||||||||||||||||||||
net increase in cash and cash equivalents | 65,829,000 | 194,729,000 | 862,333,000 | -87,583,000 | -62,925,000 | 170,620,000 | 53,386,000 | 114,393,000 | 286,429,000 | 42,124,000 | 128,093,000 | 220,430,000 | -100,613,000 | -80,332,000 | -219,620,000 | -1,206,133,000 | 1,039,764,000 | 315,827,000 | -44,140,000 | 84,480,000 | 64,258,000 | -157,831,000 | 157,436,000 | 90,273,000 | 237,844,000 | -189,396,000 | 13,937,000 | 31,912,000 | 67,134,000 | -604,000 | -501,399,000 | -111,814,000 | -9,005,000 | -10,074,000 | 77,216,000 | 139,040,000 | 98,561,000 | 109,002,000 | 306,785,000 | 22,381,000 | -390,630,000 | 48,042,000 | 84,155,000 | 53,796,000 | 63,315,000 | 197,403,000 | 35,250,000 | -16,111,000 | 88,578,000 | -19,139,000 | -1,181,000 | 37,335,000 | 20,267,000 | 21,941,000 | 3,403,000 | -25,004,000 | -1,295,000 | -17,027,000 | -28,028,000 | |||||||||||||||
cash and cash equivalents, at beginning of period | 0 | 0 | 0 | 2,412,864,000 | 0 | 0 | 0 | 1,506,310,000 | 0 | 0 | 0 | 881,482,000 | 0 | 0 | 0 | 591,448,000 | 0 | 0 | 0 | 1,057,769,000 | 0 | 0 | 0 | 637,344,000 | 0 | 0 | 0 | 309,622,000 | 0 | 0 | 0 | 386,035,000 | 0 | 0 | 0 | 365,963,000 | 0 | 0 | 0 | 988,785,000 | 0 | 0 | 0 | 684,042,000 | 0 | 0 | 0 | 636,504,000 | 0 | 0 | 0 | 387,196,000 | 0 | 0 | 0 | 82,076,000 | 0 | 0 | 0 | 44,794,000 | 0 | 0 | 0 | 15,595,000 | 0 | 0 | 0 | 24,903,000 | 0 | 0 | 0 | 102,945,000 | 0 | 0 |
cash and cash equivalents, at end of period | 65,829,000 | 136,190,000 | -672,066,000 | 1,861,946,000 | 194,729,000 | 862,333,000 | -87,583,000 | 1,443,385,000 | 170,620,000 | 53,386,000 | 114,393,000 | 1,167,911,000 | 42,124,000 | 128,093,000 | 220,430,000 | 490,835,000 | -80,332,000 | -219,620,000 | -1,206,133,000 | 2,097,533,000 | 315,827,000 | -44,140,000 | 84,480,000 | 701,602,000 | -157,831,000 | 157,436,000 | 90,273,000 | 547,466,000 | -189,396,000 | 13,937,000 | 31,912,000 | 453,169,000 | 133,420,000 | 13,402,000 | -107,782,000 | 346,995,000 | -604,000 | -501,399,000 | -111,814,000 | 979,780,000 | -10,074,000 | 77,216,000 | 139,040,000 | 782,603,000 | 109,002,000 | 306,785,000 | 22,381,000 | 245,874,000 | 48,042,000 | 84,155,000 | 53,796,000 | 450,511,000 | 197,403,000 | 35,250,000 | -16,111,000 | 170,654,000 | -19,139,000 | -1,181,000 | 37,335,000 | 65,061,000 | 21,941,000 | 13,279,000 | -9,424,000 | 18,998,000 | 3,365,000 | -3,542,000 | -1,243,000 | 17,015,000 | -25,004,000 | -1,295,000 | -49,569,000 | 100,771,000 | -17,027,000 | -28,028,000 |
supplemental disclosure of cash flow information: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash paid for interest | 4,554,000 | 3,616,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash paid for income taxes, net of refunds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
prepaid expenses and other current assets | -6,674,000 | -28,065,000 | 36,277,000 | 9,866,000 | -34,164,000 | -20,075,000 | 54,947,000 | -88,852,000 | -33,935,000 | -45,424,000 | 42,032,000 | 11,987,000 | 1,147,000 | -516,000 | 23,170,000 | -48,598,000 | -13,371,000 | -18,454,000 | -2,897,000 | -33,140,000 | -20,049,000 | -27,010,000 | -17,843,000 | -2,792,000 | -6,929,000 | -14,941,000 | -988,000 | -292,000 | 12,257,000 | -1,734,000 | -3,534,000 | -16,284,000 | -9,720,000 | 9,767,000 | -10,637,000 | -7,188,000 | 1,823,000 | -9,104,000 | -1,231,000 | 9,018,000 | 8,378,000 | 1,994,000 | -15,670,000 | 7,674,000 | 3,326,000 | -3,421,000 | 4,357,000 | -2,571,000 | 3,372,000 | -8,400,000 | -6,272,000 | -9,248,000 | 1,547,000 | -3,173,000 | -2,217,000 | 117,000 | 769,000 | -978,000 | -842,000 | 817,000 | 121,000 | 173,000 | -685,000 | 1,571,000 | 258,000 | 522,000 | 259,000 | 949,000 | 193,000 | 500,000 | -951,000 | 361,000 | -764,000 | |
operating lease assets | 3,178,000 | 6,527,000 | 5,913,000 | 6,414,000 | 3,498,000 | 3,496,000 | 3,703,000 | 525,000 | 2,845,000 | 7,070,000 | 4,508,000 | 4,097,000 | 3,733,000 | 3,844,000 | 3,095,000 | 3,529,000 | 4,161,000 | 4,203,000 | 3,690,000 | 2,636,000 | 3,308,000 | 3,227,000 | 3,195,000 | 3,229,000 | 3,520,000 | |||||||||||||||||||||||||||||||||||||||||||||||||
other non-current assets | 18,824,000 | -50,000 | -752,000 | -40,276,000 | -3,845,000 | -1,609,000 | -4,090,000 | 4,997,000 | -7,973,000 | -3,367,000 | -9,541,000 | -20,032,000 | -3,677,000 | -1,308,000 | 979,000 | 2,654,000 | -1,664,000 | -330,000 | 157,000 | 7,972,000 | 11,959,000 | 1,659,000 | 323,000 | -17,081,000 | 1,557,000 | 268,000 | 426,000 | |||||||||||||||||||||||||||||||||||||||||||||||
operating lease liabilities, less current portion | -3,475,000 | -1,797,000 | -1,090,000 | -15,040,000 | -2,792,000 | -3,929,000 | -2,980,000 | -3,110,000 | -1,905,000 | -6,991,000 | -4,959,000 | -4,283,000 | -4,054,000 | -4,170,000 | -3,915,000 | -2,614,000 | -4,633,000 | -4,608,000 | -4,182,000 | -2,499,000 | -2,906,000 | -3,072,000 | -3,906,000 | -2,907,000 | -3,568,000 | |||||||||||||||||||||||||||||||||||||||||||||||||
other non-current liabilities | 529,000 | 792,000 | 3,971,000 | -14,851,000 | 2,161,000 | 1,990,000 | -3,831,000 | -26,671,000 | 1,200,000 | 17,465,000 | 1,835,000 | -18,163,000 | -4,295,000 | 5,932,000 | 5,130,000 | -21,425,000 | 5,136,000 | 6,569,000 | 4,774,000 | -42,221,000 | 7,342,000 | 18,596,000 | 7,316,000 | 7,195,000 | -17,811,000 | 7,404,000 | 6,773,000 | 7,293,000 | -6,711,000 | 6,304,000 | 7,651,000 | 6,003,000 | -2,602,000 | 7,359,000 | 8,174,000 | 4,847,000 | 3,765,000 | 7,195,000 | 7,392,000 | 8,093,000 | 5,198,000 | 6,451,000 | 6,820,000 | 4,814,000 | 4,449,000 | 3,772,000 | 4,689,000 | 4,695,000 | 3,416,000 | 3,513,000 | 3,196,000 | |||||||||||||||||||||||
net decrease in cash and cash equivalents | -672,066,000 | -550,918,000 | 13,402,000 | -107,782,000 | -18,968,000 | -3,542,000 | -1,243,000 | -7,888,000 | -2,174,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net loss | -92,541,000 | 5,653,000 | -1,672,000 | 2,171,000 | -12,988,000 | -56,940,000 | -28,810,000 | -51,879,000 | -46,710,000 | -60,020,000 | -19,359,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
adjustments to reconcile net loss to net cash from operating activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
intangible asset impairment charge | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on disposal of a business | -1,554,000 | -1,556,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred revenue | -4,000 | 0 | 0 | -459,000 | -523,000 | -523,000 | -524,000 | -523,000 | -697,000 | -697,000 | -274,000 | -637,000 | -1,180,000 | -1,180,000 | -1,180,000 | -1,180,000 | -1,180,000 | -1,180,000 | -1,180,000 | -1,874,000 | -1,874,000 | -1,874,000 | -1,874,000 | -1,875,000 | -2,154,000 | -2,157,000 | -2,170,000 | 27,490,000 | -633,000 | -206,000 | -210,000 | -266,000 | 123,000 | -277,000 | -97,000 | -285,000 | -285,000 | -361,000 | -284,000 | -273,000 | -285,000 | -284,000 | -285,000 | -207,000 | -1,157,000 | -298,000 | 535,000 | -285,000 | -284,000 | -513,000 | -479,000 | 3,000 | -2,424,000 | -296,000 | -69,000 | 249,000 | -110,000 | -134,000 | -10,540,000 | -2,000 | -362,000 | 8,685,000 | 1,652,000 | -285,000 | -789,000 | -313,000 | ||||||||
proceeds from sale of a business | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net proceeds from issuance of exchangeable senior notes, due 2030 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repayment of exchangeable senior notes, due 2024 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred tax expense | -145,377,000 | -64,559,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
acquisition of a business, net of cash acquired | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net proceeds from issuance of borrowings under credit agreement | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net proceeds from issuance of senior secured notes, due 2029 | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payments for repurchase of exchangeable senior notes, due 2021 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
impairment charge | 0 | 0 | 0 | 136,139,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
distributions from equity method investees | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net proceeds from issuance of exchangeable senior notes, due 2026 | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net proceeds from revolving credit facility | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repayments under revolving credit facility | 0 | 0 | 0 | -500,000,000 | -200,000,000 | -150,000,000 | -80,000,000 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net proceeds from sale of assets | -194,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred tax provision | -74,994,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payments for partial repurchase of exchangeable senior notes, due 2021 | 0 | -23,300,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of debt discount and deferred financing costs | 15,688,000 | 16,046,000 | 15,820,000 | 12,793,000 | 12,000,000 | 11,981,000 | 11,831,000 | 11,451,000 | 11,133,000 | 11,291,000 | 11,165,000 | 10,887,000 | 10,617,000 | 10,792,000 | 7,855,000 | 5,764,000 | 5,615,000 | 5,715,000 | 5,642,000 | 5,414,000 | 5,362,000 | 5,390,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
impairment charges | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on extinguishment and modification of debt | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from revolving credit facility | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from tenant improvement allowance on build-to-suit lease | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on extinguishment of debt | 614,000 | 150,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
acquisitions, net of cash acquired | 0 | 0 | 0 | 0 | -828,676,000 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on disposal of assets | 73,000 | 13,000 | 1,000 | 4,000 | 3,000 | 3,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net proceeds from issuance of debt | -91,000 | -130,000 | -318,000 | -2,043,000 | -981,000 | 559,011,000 | 0 | 636,355,000 | 0 | 0 | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred income taxes | -12,430,000 | -16,921,000 | -15,307,000 | -172,232,000 | -23,403,000 | -14,956,000 | -15,000,000 | -24,701,000 | -15,410,000 | 910,000 | -1,962,000 | -35,841,000 | -8,495,000 | -7,612,000 | -9,261,000 | -7,177,000 | -17,648,000 | -14,220,000 | -4,378,000 | 7,865,000 | -8,898,000 | -5,190,000 | -3,874,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||
other long-term assets | -2,911,000 | 405,000 | -3,988,000 | 1,944,000 | 442,000 | -97,000 | -2,170,000 | 5,187,000 | -524,000 | -2,411,000 | -1,985,000 | -2,167,000 | -2,897,000 | -3,380,000 | -3,278,000 | -3,116,000 | -2,410,000 | -1,820,000 | -1,545,000 | -885,000 | -804,000 | -1,618,000 | -999,000 | -1,194,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||
loss on disposal of property, plant and equipment | -141,000 | 256,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on disposal of property and equipment | 113,000 | -97,000 | 375,000 | 82,000 | 44,000 | -34,000 | 0 | 37,000 | 55,000 | 71,000 | 38,000 | 8,000 | 2,000 | -1,000 | 7,000 | 0 | 40,000 | 17,000 | 7,000 | 18,000 | 0 | -34,000 | 0 | 0 | 5,000 | 9,000 | 830,000 | 0 | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||
purchases of property and equipment | -8,878,000 | -8,347,000 | -8,151,000 | -3,574,000 | -1,277,000 | -2,382,000 | -1,701,000 | -2,472,000 | -3,367,000 | -5,159,000 | -13,022,000 | -14,410,000 | -13,548,000 | -8,139,000 | -11,133,000 | -3,527,000 | -3,102,000 | -2,164,000 | -3,567,000 | -1,143,000 | -983,000 | -2,499,000 | -2,209,000 | -285,000 | -756,000 | -362,000 | -95,000 | -66,000 | -113,000 | -316,000 | -216,000 | -86,000 | -6,000 | -30,000 | -12,000 | -5,000 | -74,000 | -56,000 | -1,151,000 | -458,000 | -1,043,000 | -593,000 | ||||||||||||||||||||||||||||||||
net proceeds from sale of business | 0 | 0 | 1,000,000 | 32,703,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
acquisition of noncontrolling interests | -13,000 | -19,000 | -310,000 | -17,465,000 | -119,175,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
acquisition of in-process research and development | 0 | -15,000,000 | 0 | -8,750,000 | -626,000 | -75,000,000 | -2,000,000 | -125,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from employee equity incentive and purchase plans and exercise of warrants | 5,676,000 | 6,498,000 | 7,295,000 | 10,035,000 | 16,810,000 | 10,175,000 | 21,467,000 | 7,126,000 | 8,114,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
acquisition accounting inventory fair value step-up adjustments | 0 | 0 | 2,455,000 | 8,022,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
contingent consideration | 0 | 0 | 0 | -14,900,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payment of contingent consideration | 0 | 0 | 0 | -35,100,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
excess tax benefit from share-based compensation | 4,435,000 | -7,938,000 | -10,635,000 | 2,234,000 | -3,283,000 | 4,985,000 | -5,777,000 | 255,000 | -889,000 | -5,519,000 | 1,972,000 | -4,324,000 | -1,914,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from employee equity incentive plans | 3,780,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
change in fair value of contingent consideration | 2,300,000 | 5,000,000 | 3,400,000 | 4,500,000 | -1,400,000 | 900,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from employee equity incentive plans and exercise of warrants | 13,504,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
amortization of intangible assets | 31,977,000 | 30,630,000 | 32,795,000 | 31,182,000 | 20,524,000 | 19,564,000 | 19,399,000 | 19,555,000 | 21,908,000 | 21,750,000 | 15,751,000 | 13,513,000 | 1,862,000 | 1,862,000 | 1,862,000 | 1,862,000 | 1,862,000 | 1,862,000 | 2,044,000 | 2,057,000 | 2,057,000 | 2,057,000 | 1,822,000 | 1,732,000 | 3,374,000 | 3,488,000 | 3,845,000 | 2,121,000 | 2,280,000 | 2,288,000 | ||||||||||||||||||||||||||||||||||||||||||||
gain on sale of business | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability under government settlement | 0 | 0 | 0 | -7,320,000 | 95,000 | 95,000 | -1,072,000 | -2,904,000 | 126,000 | 123,000 | 121,000 | -2,876,000 | -2,346,000 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of marketable securities | 0 | 0 | -6,815,000 | -30,628,000 | -67,751,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of marketable securities | 0 | 0 | 66,164,000 | 15,082,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from maturities of marketable securities | 0 | 0 | 14,150,000 | 17,838,000 | 0 | 0 | 0 | 1,004,000 | 25,000 | 501,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchase of product rights | -5,750,000 | -1,250,000 | -8,250,000 | -1,250,000 | -1,125,000 | -1,125,000 | -1,125,000 | -1,125,000 | -1,000,000 | -1,000,000 | -1,000,000 | -1,000,000 | -1,000,000 | -7,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
intangible asset impairment | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repayment of long-term debt | -2,505,000 | -2,299,000 | -1,393,000 | -1,393,000 | -457,186,000 | -5,938,000 | -5,937,000 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
decrease in restricted cash | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payments of debt extinguishment costs | -150,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net repayments under revolving credit facility | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
acquisition accounting inventory fair value step-up | 512,000 | 1,086,000 | 1,545,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash acquired from merger with azur pharma | 81,751,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of intangible assets | -1,300,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from exercise of share options and warrants | 9,609,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from employee share purchases, exercise of share options and warrants | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
payment of employee withholding taxes upon exercise of share-based awards | 0 | 0 | 0 | -25,299,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from offerings of common stock, net of issuance costs | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
share-based compensation expense | 6,612,000 | 5,258,000 | 3,281,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchase accounting inventory fair value step-up | 11,442,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
movement in deferred income taxes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other long-term liabilities | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from employee stock purchases, exercise of stock options and warrants | 2,422,000 | 2,951,000 | 4,057,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other assets and liabilities | -892,000 | -299,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from exercise of stock options and warrants | 5,160,000 | 4,526,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net repayments under revolving credit facilities | -4,000,000 | 0 | -3,350,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stock-based compensation expense | 10,946,000 | 3,195,000 | 3,415,000 | 3,148,000 | 2,250,000 | 2,177,000 | 1,960,000 | 1,832,000 | 2,448,000 | 1,313,000 | 1,114,000 | 1,082,000 | 2,316,000 | 1,688,000 | 1,875,000 | 2,227,000 | 2,287,000 | 1,793,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term debt, non-cash interest expense | 0 | 0 | 188,000 | 206,000 | 231,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other assets | -4,000 | 69,000 | -101,000 | -731,000 | 247,000 | -517,000 | -4,000 | 261,000 | 160,000 | -269,000 | -232,000 | 304,000 | -266,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred rent | 0 | -12,000 | -65,000 | -5,000 | -4,000 | 13,000 | 22,000 | 22,000 | 22,000 | -85,000 | -75,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of long-term debt | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net (repayments under) proceeds from revolving credit facilities | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
supplemental disclosure of non-cash investing and financing activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liability for purchase of product rights | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
warrants to purchase common stock | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
modification to warrants to purchase common stock issued in conjunction with long-term debt | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
decrease in restricted cash and investments | 0 | 510,000 | 41,000 | 2,037,000 | -2,038,000 | 125,000 | -300,000 | 1,138,000 | 85,000 | 0 | 0 | 11,941,000 | -1,550,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repayment of senior secured notes | 0 | 0 | -116,496,000 | -3,000,000 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from term loan | -261,000 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repayment of term loan | -4,166,000 | -4,166,000 | -4,166,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on sale of product rights | 0 | -715,000 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
transfer of restricted cash to marketable securities | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of product rights | 0 | 1,150,000 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
prepayment penalties and fees | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from employee stock purchases and exercise of stock options and warrants | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of senior secured notes and warrants, net of issuance costs | -28,000 | 0 | -634,000 | 39,200,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
modification to warrants to purchase common stock issued in conjunction with senior secured notes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
loss on extinguishment of debt, non-cash portion | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from offering of common stock, net of issuance costs | -302,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from private offerings, net of issuance costs | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from employee stock purchases and exercise of stock options | 67,000 | 236,000 | 25,000 | 192,000 | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net repayment of revolving credit facilities | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
warrants to purchase common stock issued in conjunction with unregistered sales of equity securities | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
senior secured notes, non-cash interest expense | 873,000 | 1,050,000 | 701,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
senior secured notes, accrued and unpaid interest | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from exercise of employee stock options | 511,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net repayment of revolving line of credit | -1,559,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fair value adjustment to acquired finished goods | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
revaluation of preferred stock warrant liability | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
senior secured notes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net proceeds from line of credit | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
warrants to purchase common stock issued in conjunction with registered direct public offering | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
warrants to purchase common stock issued in conjunction with senior secured notes | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
warrants to purchase common stock issued in conjunction with equity financing facility | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of product rights | -2,000,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net repayments of line of credit | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from public offerings, net of issuance costs | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
common stock issued as employee bonuses | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued unpaid interest on senior secured notes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
provision for government settlement | 149,000 | 62,000 | -1,818,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net (repayments of) proceeds from line of credit | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued unpaid interest for senior secured notes | 5,078,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from exercise of stock options | 2,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repayment under line of credit | -3,875,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest on development financing | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on extinguishment of development financing | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of property and equipment | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from maturites of long-term restricted cash equivalents | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuances of convertible preferred stock, net of issuance costs | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from line of credit | 6,100,000 | 3,179,000 | 4,307,000 | 3,308,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from development financing | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
beneficial conversion feature - deemed dividend attributable to preferred stockholders | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
transfer of long-term restricted investments to marketable securities | 0 | 0 | -4,410,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of common stock in initial public offering, net of issuance costs | -650,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net (repayments under) proceeds from line of credit | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of common stock in registered direct public offering, net of issuance costs | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
supplemental disclosure of non-cash financing and investing activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
conversion of preferred stock warrant liability to stockholders’ equity | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchased product rights liability | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchase of developed technology | -10,000,000 | -10,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
repayments under line of credit | -3,181,000 | -3,458,000 | -3,445,000 | -3,845,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
supplemental disclosure of non-cash financing activities: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fair value of warrants granted under 40.0 million senior notes | 2,000,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchased in-process research and development | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
purchases of available-for-sale securities | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sales of available-for-sale securities | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from maturities of available-for-sale securities | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash paid for shares of orphan medical, inc., net of cash acquired | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from maturites of long term restricted cash equivalents | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from initial public offering | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from sale of senior secured notes, net of issuance costs | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
warrants to purchase series bb convertible preferred stock issued in conjuction with senior secured notes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
beneficial conversion feature—deemed dividend attributable to preferred stockholders | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
depreciation and amortization | 332,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
excess of cash paid over accrued for interest | 315,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
gain on extinguishment of development financing obligation | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuances of common stock, net of issuance costs | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
increase in restricted cash and investments |