7Baggers
Quarterly
Annual
    Unit: USD2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-09-30 2019-06-30 2019-03-31 2018-09-30 2018-06-30 2018-03-31 2017-09-30 2017-06-30 2017-03-31 2016-09-30 2016-06-30 2016-03-31 2015-09-30 2015-06-30 2015-03-31 2014-09-30 2014-06-30 2014-03-31 2013-09-30 2013-06-30 2013-03-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 
      
    		                                                                 
      operating activities
    		                                                                 
      net income
    		251,412,000 -718,470,000 -92,541,000  215,055,000 168,568,000 -14,618,000  146,820,000 104,438,000 69,420,000  -19,648,000 34,665,000 1,647,000  -52,833,000 -363,316,000 121,832,000  148,234,000 114,801,000 -157,833,000 102,276,000 261,898,000 85,201,000 149,316,000 92,321,000 45,991,000 63,526,000 105,604,000 86,511,000 87,145,000 111,282,000 74,121,000 87,960,000 88,113,000 70,700,000 25,768,000 43,586,000 -93,639,000 75,409,000 42,185,000 43,425,000 33,209,000 27,145,000 27,681,000 37,473,000 32,482,000 33,202,000 21,827,000 24,459,000 13,243,000 -6,388,000 1,464,000 5,653,000 -1,672,000 2,171,000 -12,988,000 -56,940,000 -28,810,000 -51,879,000 -46,710,000 -60,020,000 -19,359,000 
      adjustments to reconcile net income to net cash from operating activities:
    		                                                                 
      acquired in-process research and development
    		42,500,000    0 0 10,000,000  0 0 1,000,000  0        10,000,000 3,000,000 202,250,000 51,775,000 2,200,000 56,000,000    75,000,000   15,000,000 0 8,750,000    75,000,000 0 127,000,000                         
      intangible asset amortization
    		168,368,000 162,103,000 154,448,000  157,457,000 155,223,000 155,730,000  154,883,000 152,062,000 149,786,000  141,232,000 148,456,000 172,094,000  159,804,000 140,480,000 68,192,000  66,684,000 62,974,000 62,847,000 62,863,000 61,576,000 56,885,000 46,989,000 54,959,000 53,007,000 47,313,000 26,186,000 25,665,000 26,453,000 26,737,000 22,642,000 26,127,000 23,668,000 24,677,000                            
      share-based compensation
    		88,125,000 64,501,000 67,653,000  59,760,000 56,654,000 61,441,000  56,115,000 61,433,000 56,352,000  56,681,000 53,687,000 50,070,000  53,239,000 48,163,000 34,485,000  30,356,000 30,604,000 28,654,000 28,785,000 28,289,000 27,552,000 25,103,000 26,312,000 24,303,000 27,126,000 27,260,000 25,193,000 24,874,000 25,433,000 24,183,000 23,114,000 23,300,000 20,819,000 18,251,000 18,552,000 13,815,000 11,876,000 11,506,000 8,757,000                      
      acquisition accounting inventory fair value step-up adjustment
    		40,355,000 37,109,000 29,880,000  35,034,000 33,243,000 28,943,000  30,822,000 27,814,000 60,458,000  70,964,000 68,282,000 63,943,000  82,646,000                                                 
      depreciation
    		9,878,000 11,906,000 10,425,000  7,775,000 7,812,000 7,653,000  7,675,000 7,515,000 7,574,000  7,594,000 7,747,000 7,617,000  7,773,000 6,835,000 4,779,000  4,810,000 4,739,000 4,527,000 3,991,000 3,355,000 3,539,000 3,906,000 3,735,000 3,722,000 3,065,000 3,093,000 3,130,000 3,121,000 2,517,000 2,527,000 2,548,000 2,363,000 2,232,000 1,868,000 1,860,000 1,309,000 895,000 595,000 575,000 374,000 229,000 186,000 111,000 79,000 85,000 104,000 173,000 188,000 224,000 301,000 326,000 364,000 369,000 370,000 438,000 609,000 627,000 524,000   
      non-cash interest expense
    		5,299,000 4,848,000 17,066,000  7,677,000 5,212,000 5,988,000  6,062,000 5,427,000 4,766,000  14,262,000 5,572,000 12,168,000  28,045,000                                          535,000 625,000 592,000 513,000 330,000   
      benefit from losses on accounts receivable and inventory
    		8,223,000 1,452,000 5,319,000  2,680,000 5,783,000 7,403,000  2,182,000 3,234,000 2,316,000  6,916,000 3,980,000 2,170,000  4,702,000 7,659,000 1,083,000  5,070,000 1,458,000 2,620,000 1,444,000 1,875,000 528,000 2,064,000 2,080,000 590,000 277,000 600,000 948,000 76,000 790,000 898,000 3,411,000 184,000 426,000 948,000 1,112,000 813,000 522,000 1,094,000 142,000                      
      deferred tax benefit
    		-271,410,000 -66,419,000 -43,833,000  -64,404,000 -75,183,000 -66,385,000  -78,922,000 -79,334,000 -66,061,000    -45,339,000    -19,110,000  -38,141,000 -18,792,000 -63,976,000 -16,588,000 -134,294,000 -17,053,000                                        
      other non-cash transactions
    		1,016,000 13,579,000 -6,537,000  4,095,000 846,000 14,674,000  6,106,000 31,383,000 16,773,000  2,743,000 -14,394,000 -14,701,000  6,639,000 -4,783,000 7,766,000  9,176,000 1,594,000 1,902,000 -1,890,000 -3,728,000 1,181,000 -4,026,000 -5,030,000 16,026,000 6,480,000 6,595,000 1,405,000 493,000 -612,000 1,579,000 -11,772,000 7,306,000 632,000 -2,686,000 1,039,000 1,868,000 1,184,000 1,276,000 1,975,000 1,462,000 -2,102,000 2,411,000                   
      changes in assets and liabilities:
    		                                                                 
      accounts receivable
    		-50,996,000 -55,519,000 66,049,000  -22,256,000 8,720,000 -8,443,000  -18,858,000 13,979,000 28,460,000  -9,637,000 -24,508,000 -9,723,000  6,882,000 -16,593,000 -18,245,000  -8,644,000 -34,221,000 37,861,000 43,267,000 9,386,000 -56,960,000 -1,162,000 2,235,000 -56,591,000 -19,235,000 5,445,000 -8,483,000 -6,116,000 -8,356,000 -13,802,000 -2,182,000 -3,710,000 -4,769,000 -28,801,000 -5,875,000 -16,014,000 1,366,000 -20,104,000 -18,911,000 -10,346,000 1,367,000 -8,794,000 -2,946,000 -6,429,000 -3,616,000 698,000 -7,967,000 -19,000 -2,140,000 358,000 -3,111,000 -5,000 -2,185,000 -369,000 43,000 -1,465,000 89,000 79,000 927,000 -104,000 
      inventories
    		-31,909,000 -26,231,000 -35,621,000  -9,286,000 -4,747,000 -12,844,000  -4,934,000 -816,000 -6,266,000  -8,529,000 -17,117,000 -24,812,000  -4,489,000 -7,388,000 -22,014,000  -3,035,000 -8,591,000 -10,235,000 -4,466,000 -9,874,000 -8,688,000 1,355,000 -5,626,000 -3,312,000 -1,253,000 -1,621,000 -4,258,000 933,000 -8,743,000 -6,307,000 -1,746,000 -7,000 -1,842,000 -6,882,000 -231,000 -3,071,000 2,659,000 -7,335,000 1,231,000 909,000 864,000 -58,000 506,000 440,000 302,000 50,000 -613,000 -49,000 -911,000 -71,000 631,000 -329,000 223,000 358,000 1,450,000 -56,000 -4,038,000 10,000 1,026,000 -2,000 
      prepaid expenses and other current assets
    		-6,674,000 -28,065,000 36,277,000  -34,164,000 -20,075,000 54,947,000  -33,935,000 -45,424,000 42,032,000  1,147,000 -516,000 23,170,000  -13,371,000 -18,454,000 -2,897,000  -20,049,000 -27,010,000 -17,843,000 -6,929,000 -14,941,000 -988,000 12,257,000 -1,734,000 -3,534,000 -9,720,000 9,767,000 -10,637,000 1,823,000 -9,104,000 -1,231,000 8,378,000 1,994,000 -15,670,000 3,326,000 -3,421,000 4,357,000 3,372,000 -8,400,000 -6,272,000 1,547,000 -3,173,000 -2,217,000 117,000 769,000 -978,000 -842,000 817,000 121,000 173,000 -685,000 1,571,000 258,000 522,000 259,000 949,000 193,000 500,000 -951,000 361,000 -764,000 
      operating lease assets
    		3,178,000 6,527,000 5,913,000  3,498,000 3,496,000 3,703,000  2,845,000 7,070,000 4,508,000  3,733,000 3,844,000 3,095,000  4,161,000 4,203,000 3,690,000  3,308,000 3,227,000 3,195,000 3,520,000                                          
      other non-current assets
    		18,824,000 -50,000 -752,000  -3,845,000 -1,609,000 -4,090,000  -7,973,000 -3,367,000 -9,541,000  -3,677,000 -1,308,000 979,000  -1,664,000 -330,000 157,000  11,959,000 1,659,000 323,000 1,557,000 268,000 426,000                                        
      accounts payable
    		62,358,000 -12,666,000 19,131,000  -12,790,000 15,449,000 -19,597,000  10,243,000 -26,824,000 34,286,000  28,959,000 2,846,000 -27,617,000  -142,000 -31,983,000 51,292,000  15,381,000 -14,340,000 19,604,000 43,200,000 -15,650,000 1,554,000 2,745,000 -15,765,000 23,136,000 783,000 -518,000 5,865,000 -10,512,000 -4,440,000 10,664,000 2,697,000 -1,174,000 3,303,000 -2,310,000 -40,134,000 8,579,000 1,963,000 -11,451,000 16,158,000 -13,906,000 6,714,000 4,649,000 -3,334,000 3,798,000 1,017,000 599,000 -842,000 -2,512,000 2,518,000 1,727,000 -3,082,000 1,166,000 -480,000 -1,182,000 -878,000 -1,908,000 -393,000 6,059,000 -16,000 -1,036,000 
      accrued liabilities
    		126,277,000 -256,389,000 181,038,000  51,024,000 -29,273,000 34,677,000  13,547,000 7,177,000 -96,985,000  62,294,000 -21,189,000 -23,241,000  36,846,000 42,969,000 13,719,000  33,482,000 5,226,000 -12,198,000 21,662,000 -56,346,000 -2,685,000 4,966,000 12,624,000 47,484,000 9,489,000 -17,329,000 -15,743,000 -4,058,000 1,117,000 -6,706,000 22,777,000 -650,000 -17,485,000 20,289,000 -1,748,000 927,000 9,311,000 -5,089,000 -2,660,000 -4,012,000 22,878,000 -6,539,000 -1,051,000 9,121,000 3,439,000 -298,000 4,497,000 3,171,000 536,000 1,072,000 2,707,000 -5,409,000 597,000 -90,000 -655,000 -7,947,000 2,753,000 476,000 5,501,000 1,820,000 
      income taxes payable
    		12,738,000 46,282,000 12,988,000  2,068,000 3,172,000 14,858,000  15,222,000 20,524,000 25,413,000  4,296,000 -21,235,000 16,767,000  31,010,000 -46,464,000 24,625,000  -30,392,000 24,652,000 20,829,000 13,763,000 -10,676,000 39,726,000 -10,714,000 -17,468,000 14,183,000 6,008,000 -28,266,000 30,753,000 -75,000 -22,360,000 25,758,000 2,496,000 -23,666,000 30,163,000 13,549,000 -303,000 5,757,000 2,812,000 -20,501,000 -1,397,000                      
      operating lease liabilities, less current portion
    		-3,475,000 -1,797,000 -1,090,000  -2,792,000 -3,929,000 -2,980,000  -1,905,000 -6,991,000 -4,959,000  -4,054,000 -4,170,000 -3,915,000  -4,633,000 -4,608,000 -4,182,000  -2,906,000 -3,072,000 -3,906,000 -3,568,000                                          
      other non-current liabilities
    		529,000 792,000 3,971,000  2,161,000 1,990,000 -3,831,000  1,200,000 17,465,000 1,835,000  -4,295,000 5,932,000 5,130,000  5,136,000 6,569,000 4,774,000  7,342,000 18,596,000 7,316,000 -17,811,000 7,404,000 6,773,000 -6,711,000 6,304,000 7,651,000 -2,602,000 7,359,000 8,174,000 3,765,000 7,195,000 7,392,000 5,198,000 6,451,000 6,820,000 4,449,000 3,772,000 4,689,000 3,416,000 3,513,000 3,196,000                      
      net cash from operating activities
    		474,616,000 88,855,000 429,784,000 398,580,000 398,747,000 331,352,000 267,229,000 167,339,000 307,195,000 296,765,000 320,708,000 341,971,000 417,991,000 303,036,000 208,979,000 177,755,000 274,060,000 41,695,000 284,997,000 186,271,000 257,889,000 182,519,000 272,969,000 337,503,000 148,847,000 202,253,000 220,575,000 191,624,000 162,359,000 188,897,000 135,091,000 164,540,000 136,531,000 129,594,000 143,716,000 175,076,000 140,571,000 96,555,000 129,697,000 74,924,000 68,723,000 129,800,000 8,719,000 65,890,000 44,143,000 76,969,000 24,295,000 43,659,000 46,053,000 37,436,000 24,448,000 31,275,000 18,486,000 2,607,000 6,500,000 1,772,000 -11,442,000 -1,058,000 -5,150,000 -18,786,000 -28,689,000 -44,587,000 -38,170,000 -28,061,000 -15,371,000 
      capex
    		-15,175,000 -12,967,000 -13,881,000 0 -10,788,000 -7,091,000 -6,904,000 0 -4,299,000 -5,739,000 -3,822,000 0 4,902,000 -12,278,000 -12,292,000 0 -8,328,000 -7,178,000 -2,168,000 0 -3,369,000 -2,690,000 -4,830,000 -11,087,000 -13,963,000 -7,948,000 -3,940,000 -4,132,000 -7,149,000 -8,347,000 -8,151,000 -3,574,000 -2,382,000 -1,701,000 -2,472,000 -5,159,000 -13,022,000 -14,410,000 -8,139,000 -11,133,000 -3,527,000 -2,164,000 -3,567,000 -1,143,000 -2,499,000 -2,209,000 -285,000 -756,000 -362,000 -95,000 -66,000 -113,000 -316,000 -216,000 -86,000 -6,000 -30,000 -12,000 -5,000 -74,000 -56,000 -1,151,000 -458,000 -1,043,000 -593,000 
      free cash flows
    		459,441,000 75,888,000 415,903,000 398,580,000 387,959,000 324,261,000 260,325,000 167,339,000 302,896,000 291,026,000 316,886,000 341,971,000 422,893,000 290,758,000 196,687,000 177,755,000 265,732,000 34,517,000 282,829,000 186,271,000 254,520,000 179,829,000 268,139,000 326,416,000 134,884,000 194,305,000 216,635,000 187,492,000 155,210,000 180,550,000 126,940,000 160,966,000 134,149,000 127,893,000 141,244,000 169,917,000 127,549,000 82,145,000 121,558,000 63,791,000 65,196,000 127,636,000 5,152,000 64,747,000 41,644,000 74,760,000 24,010,000 42,903,000 45,691,000 37,341,000 24,382,000 31,162,000 18,170,000 2,391,000 6,414,000 1,766,000 -11,472,000 -1,070,000 -5,155,000 -18,860,000 -28,745,000 -45,738,000 -38,628,000 -29,104,000 -15,964,000 
      investing activities
    		                                                                 
      acquisition of investments
    		-640,125,000 -240,000,000 -440,050,000  -130,125,000 -330,000,000 -375,000,000  -190,000,000    -300,000    -594,000 -5,400,000 -20,700,000  -621,275,000 -855,475,000 -185,000,000 -225,000,000 -245,975,000 -115,000,000 -415,000,000 -265,000,000 -235,000,000 -270,000,000   -11,209,000 -52,711,000 -773,000                               
      asset acquisition, net of cash acquired
    		0                                                                 
      acquisition of intangible assets
    		-30,000,000 0 -25,000,000          0 0 -25,000,000      0 -100,000,000 -13,000,000 -55,000,000   2,000      0         0                        
      purchases of property, plant and equipment
    		-15,175,000 -12,967,000 -13,881,000  -10,788,000 -7,091,000 -6,904,000  -4,299,000 -5,739,000 -3,822,000  4,902,000 -12,278,000 -12,292,000  -8,328,000 -7,178,000 -2,168,000  -3,369,000 -2,690,000 -4,830,000 -11,087,000 -13,963,000 -7,948,000 -3,940,000 -4,132,000 -7,149,000                                     
      proceeds from maturity of investments
    		400,000,000 470,000,000 310,000,000  355,000,000 80,000,000 120,000,000          0 335,000,000 760,000,000  355,000,000 220,000,000 345,000,000 190,000,000 285,000,000 345,000,000 180,000,000 190,000,000 195,000,000                                     
      net cash from investing activities
    		-327,800,000 -641,020,000 -168,931,000 -193,287,000 214,087,000 -257,091,000 -271,904,000 101,798,000 -174,299,000 -85,739,000 -4,822,000 -324,378,000 4,602,000 -89,162,000 -37,292,000 -10,092,000 -26,813,000 -5,912,370,000 737,132,000 73,219,000 -279,644,000 -741,165,000 -60,080,000 -159,661,000 -2,638,000 166,052,000 -190,846,000 -190,234,000 -47,149,000 -203,347,000 -30,151,000 -3,574,000 -1,531,034,000 -204,412,000 -11,995,000 -5,159,000 -12,022,000 18,293,000 -83,139,000 -13,133,000 -957,203,000 -2,164,000 -3,567,000 -2,443,000 -3,749,000 -561,242,000 82,508,000 -65,599,000 -13,622,000 -820,000 -1,191,000 -1,113,000 -806,000 -1,175,000 951,000 -5,044,000 -1,905,000 -312,000 1,137,000 -6,994,000 6,220,000 -8,241,000 -2,927,000 9,405,000 -11,470,000 
      financing activities
    		                                                                 
      repayments of long-term debt
    		-7,750,000 -7,750,000 -757,750,000  -7,750,000 -7,750,000 -7,750,000  -7,750,000 -7,750,000 -7,750,000  -307,746,000 -7,754,000 -258,764,000  -258,760,000 -575,921,000 -8,347,000  -8,347,000 -8,346,000 -8,347,000 -8,347,000 -8,346,000 -8,347,000 -8,347,000 0 -9,023,000 -9,023,000 -9,024,000 -9,023,000 0 -9,885,000 -9,397,000 -961,000 -893,118,000 -2,284,000                            
      share repurchases
    		0    -150,001,000    -74,371,000    0        0 -7,484,000 -139,053,000 -19,997,000 -59,869,000 -111,249,000 -21,454,000 -21,015,000 -34,546,000 -25,566,000 -16,963,000 -13,896,000 -96,575,000 -28,879,000 -134,365,000 -9,612,000 -1,352,000 -10,338,000 -6,486,000   -48,819,000                        
      payment of employee withholding taxes related to share-based awards
    		-3,812,000 -2,249,000 -67,163,000  -1,605,000 -2,847,000 -49,296,000  -1,884,000 -4,188,000 -43,266,000  -2,567,000 -6,289,000 -33,776,000  -2,431,000 -3,388,000 -23,784,000  -1,097,000 -1,116,000 -13,547,000 -1,087,000 -1,003,000 -13,810,000 -1,169,000 -1,429,000 -14,594,000 -1,589,000 -1,889,000 -14,431,000 -6,317,000 -1,802,000 -12,476,000 -8,723,000 -1,901,000 -14,778,000 -6,755,000 -1,188,000 -9,363,000 -3,706,000 -170,000 -1,427,000                      
      proceeds from employee equity incentive and purchase plans
    		733,000 10,497,000 11,447,000  17,000 10,940,000 494,000  5,512,000 10,866,000 21,228,000  21,260,000 24,874,000 21,729,000  14,822,000 51,882,000 50,407,000  10,088,000 10,987,000 13,264,000 9,968,000 13,065,000 3,057,000 16,998,000 56,470,000 10,588,000 3,722,000   3,340,000                                 
      repayment of 2024 notes
    		                                                                 
      net proceeds from issuance of 2030 notes
    		                                                                 
      net cash from financing activities
    		-10,829,000 -124,525,000 -813,466,000 -8,275,000 246,428,000 -161,085,000 -56,552,000 -100,306,000 -78,493,000 -96,667,000 -29,788,000 19,596,000 -289,053,000 10,777,000 -270,811,000 -246,609,000 -465,181,000 4,664,036,000 18,276,000 55,878,000 -22,656,000 642,534,000 -147,683,000 -19,463,000 -56,153,000 -130,349,000 -13,972,000 28,873,000 -47,575,000 27,028,000 -214,481,000 -181,674,000 891,722,000 -34,170,000 -144,520,000 -94,424,000 7,223,000 -3,261,000 263,267,000 -39,455,000 497,662,000 -45,722,000 47,456,000 3,133,000 -5,488,000 468,653,000 -18,225,000 2,801,000 -33,612,000 719,000 -2,990,000 -8,221,000 -4,401,000 -10,856,000 -4,048,000 6,637,000 9,805,000 127,000 -3,875,000 776,000 21,174,000 3,259,000 38,923,000 1,629,000 -1,187,000 
      effect of exchange rates on cash and cash equivalents
    		203,000 4,624,000 1,695,000 -2,289,000 3,071,000 -759,000 -1,698,000 1,789,000 -1,017,000 34,000 331,000 4,935,000 -5,447,000 -4,221,000 -1,489,000 -1,386,000 -1,686,000 506,000 -641,000 459,000 271,000 592,000 -948,000 -943,000 217,000 -112,000 -1,820,000 1,649,000 -501,000 824,000 1,759,000 1,740,000 1,382,000 -2,826,000 3,794,000 1,723,000 3,268,000 -13,026,000 -3,040,000 45,000 188,000 2,241,000 1,188,000 -3,265,000 344,000                     
      net increase in cash and cash equivalents
    		   194,729,000 862,333,000 -87,583,000 -62,925,000 170,620,000 53,386,000 114,393,000 286,429,000 42,124,000 128,093,000 220,430,000 -100,613,000 -80,332,000 -219,620,000 -1,206,133,000 1,039,764,000 315,827,000 -44,140,000 84,480,000 64,258,000 157,436,000 90,273,000 237,844,000 13,937,000 31,912,000 67,134,000    -501,399,000 -111,814,000 -9,005,000 77,216,000 139,040,000 98,561,000 306,785,000 22,381,000 -390,630,000 84,155,000 53,796,000 63,315,000 35,250,000 -16,111,000 88,578,000 -19,139,000 -1,181,000 37,335,000 20,267,000 21,941,000   3,403,000     -25,004,000 -1,295,000   -17,027,000 -28,028,000 
      cash and cash equivalents, at beginning of period
    		0 0 2,412,864,000  0 0 1,506,310,000  0 0 881,482,000  0 0 591,448,000  0 0 1,057,769,000  0 0 637,344,000 0 0 309,622,000 0 0 386,035,000 0 0 365,963,000 0 0 988,785,000 0 0 684,042,000 0 0 636,504,000 0 0 387,196,000 0 0 82,076,000 0 0 0 44,794,000 0 0 0 15,595,000 0 0 0 24,903,000 0 0 0 102,945,000 0 0 
      cash and cash equivalents, at end of period
    		136,190,000 -672,066,000 1,861,946,000  862,333,000 -87,583,000 1,443,385,000  53,386,000 114,393,000 1,167,911,000  128,093,000 220,430,000 490,835,000  -219,620,000 -1,206,133,000 2,097,533,000  -44,140,000 84,480,000 701,602,000 157,436,000 90,273,000 547,466,000 13,937,000 31,912,000 453,169,000 13,402,000 -107,782,000 346,995,000 -501,399,000 -111,814,000 979,780,000 77,216,000 139,040,000 782,603,000 306,785,000 22,381,000 245,874,000 84,155,000 53,796,000 450,511,000 35,250,000 -16,111,000 170,654,000 -19,139,000 -1,181,000 37,335,000 65,061,000 21,941,000 13,279,000 -9,424,000 18,998,000 3,365,000 -3,542,000 -1,243,000 17,015,000 -25,004,000 -1,295,000 -49,569,000 100,771,000 -17,027,000 -28,028,000 
      net decrease in cash and cash equivalents
    		 -672,066,000 -550,918,000                           13,402,000 -107,782,000 -18,968,000                         -3,542,000 -1,243,000 -7,888,000    -2,174,000   
      deferred revenue
    		        0 0 -459,000  -523,000 -524,000 -523,000  -697,000 -274,000 -637,000  -1,180,000 -1,180,000 -1,180,000 -1,180,000 -1,180,000 -1,874,000 -1,874,000 -1,874,000 -1,875,000 -2,157,000 -2,170,000 27,490,000 -206,000 -210,000 -266,000 -277,000 -97,000 -285,000 -361,000 -284,000 -273,000 -284,000 -285,000 -207,000 -298,000 535,000 -285,000 -284,000 -513,000 -479,000 3,000 -2,424,000 -296,000 -69,000 249,000 -110,000 -134,000 -10,540,000 -2,000 -362,000 8,685,000 1,652,000 -285,000 -789,000 -313,000 
      net proceeds from issuance of exchangeable senior notes, due 2030
    		                                                                 
      repayment of exchangeable senior notes, due 2024
    		                                                                 
      impairment charge
    		                    0 0 136,139,000                                           
      loss on disposal of a business
    		            -1,556,000                                                     
      proceeds from sale of a business
    		            0                                                     
      deferred tax expense
    		            -64,559,000                                                     
      acquisition of a business, net of cash acquired
    		                0                                                 
      net proceeds from issuance of borrowings under credit agreement
    		                0                                                 
      net proceeds from issuance of senior secured notes, due 2029
    		                0                                                 
      payments for repurchase of exchangeable senior notes, due 2021
    		                                                                 
      deferred tax provision
    		                -74,994,000                                                 
      net proceeds from issuance of exchangeable senior notes, due 2026
    		                    0                                             
      net proceeds from revolving credit facility
    		                                                                 
      repayments under revolving credit facility
    		                    0         -500,000,000 -200,000,000 -150,000,000                                  
      payments for partial repurchase of exchangeable senior notes, due 2021
    		                    -23,300,000                                             
      amortization of debt discount and deferred financing costs
    		                  15,688,000  15,820,000 12,793,000 12,000,000 11,831,000 11,451,000 11,133,000 11,165,000 10,887,000 10,617,000 7,855,000 5,764,000 5,615,000 5,642,000 5,414,000 5,362,000                               
      loss on extinguishment of debt
    		                    614,000                           150,000                  
      acquisitions, net of cash acquired
    		                                      0 0 -828,676,000    0                     
      proceeds from revolving credit facility
    		                    0                                             
      loss on disposal of assets
    		                      73,000 1,000 4,000 3,000                                        
      impairment charges
    		                          0                                       
      loss on extinguishment and modification of debt
    		                          0         0      0                        
      net proceeds from sale of assets
    		                                                                 
      proceeds from tenant improvement allowance on build-to-suit lease
    		                          0                                       
      payment of debt modification costs
    		                          0                                       
      deferred income taxes
    		                          -12,430,000 -16,921,000 -15,307,000 -23,403,000 -14,956,000 -15,000,000 -15,410,000 910,000 -1,962,000 -8,495,000 -7,612,000 -9,261,000 -17,648,000 -14,220,000 -4,378,000 -8,898,000 -5,190,000 -3,874,000                      
      other long-term assets
    		                          -2,911,000 405,000 -3,988,000 442,000 -97,000 -2,170,000 -524,000 -2,411,000 -1,985,000 -2,897,000 -3,380,000 -3,278,000 -2,410,000 -1,820,000 -1,545,000 -804,000 -1,618,000 -999,000                      
      net proceeds from issuance of debt
    		                                   -2,043,000   559,011,000 0 636,355,000 0   0                     
      loss on disposal of property, plant and equipment
    		                           -141,000 256,000                                     
      loss on disposal of property and equipment
    		                             -97,000 375,000 82,000 -34,000 0 37,000 71,000 38,000 8,000   2,000 7,000 0 40,000 7,000   18,000 0   -34,000    0 0 5,000 9,000 830,000 0   0 0 
      purchases of property and equipment
    		                             -8,347,000 -8,151,000 -3,574,000 -2,382,000 -1,701,000 -2,472,000 -5,159,000 -13,022,000 -14,410,000 -8,139,000 -11,133,000 -3,527,000 -2,164,000 -3,567,000 -1,143,000 -2,499,000 -2,209,000 -285,000 -756,000 -362,000 -95,000 -66,000 -113,000 -316,000 -216,000 -86,000 -6,000 -30,000 -12,000 -5,000 -74,000 -56,000 -1,151,000 -458,000 -1,043,000 -593,000 
      acquisition of in-process research and development
    		                                -15,000,000 0 -8,750,000    -75,000,000 -2,000,000 -125,000,000                         
      proceeds from employee equity incentive and purchase plans and exercise of warrants
    		                               5,676,000    7,295,000   16,810,000 10,175,000 21,467,000 8,114,000                        
      excess tax benefit from share-based compensation
    		                                 4,435,000 -7,938,000   -10,635,000 -3,283,000 4,985,000 -5,777,000   -889,000 1,972,000 -4,324,000 -1,914,000                   
      net proceeds from sale of business
    		                                   0 1,000,000 32,703,000                            
      acquisition of noncontrolling interests
    		                                      -310,000 -17,465,000 -119,175,000                         
      proceeds from employee equity incentive plans
    		                                  3,780,000                               
      acquisition accounting inventory fair value step-up adjustments
    		                                      0 2,455,000 8,022,000                         
      contingent consideration
    		                                      0 0 -14,900,000                         
      payment of contingent consideration
    		                                      0 0 -35,100,000                         
      proceeds from employee equity incentive plans and exercise of warrants
    		                                     13,504,000                            
      amortization of intangible assets
    		                                      30,630,000 32,795,000 31,182,000 19,564,000 19,399,000 19,555,000 21,750,000 15,751,000 13,513,000 1,862,000 1,862,000 1,862,000 1,862,000 1,862,000 1,862,000 2,044,000 2,057,000 2,057,000 2,057,000 1,822,000 1,732,000 3,374,000 3,488,000 3,845,000 2,121,000 2,280,000 2,288,000 
      intangible asset impairment
    		                                      0                           
      change in fair value of contingent consideration
    		                                         5,000,000 3,400,000 4,500,000 900,000                     
      repayment of long-term debt
    		                                       -2,505,000 -2,299,000 -1,393,000 -457,186,000 -5,938,000    0                  
      acquisition accounting inventory fair value step-up
    		                                         512,000 1,086,000 1,545,000                      
      liability under government settlement
    		                                            0 0 -7,320,000 95,000 95,000 -1,072,000 -2,904,000 126,000 123,000 121,000 -2,876,000 -2,346,000     0    0 
      purchases of marketable securities
    		                                            0 -6,815,000 -30,628,000 -67,751,000                  
      proceeds from sale of marketable securities
    		                                            0 66,164,000 15,082,000                   
      proceeds from maturities of marketable securities
    		                                            0 14,150,000 17,838,000         0 0 0 1,004,000 25,000 501,000     
      purchase of product rights
    		                                            -1,250,000 -8,250,000 -1,250,000 -1,125,000 -1,125,000 -1,125,000 -1,125,000 -1,000,000 -1,000,000 -1,000,000 -1,000,000    -1,000,000 -7,000,000      
      cash acquired from merger with azur pharma
    		                                              81,751,000                   
      purchases of intangible assets
    		                                           -1,300,000                      
      proceeds from exercise of share options and warrants
    		                                           9,609,000                      
      share-based compensation expense
    		                                            6,612,000 5,258,000 3,281,000                   
      purchase accounting inventory fair value step-up
    		                                            11,442,000                     
      movement in deferred income taxes
    		                                                                 
      other long-term liabilities
    		                                                                 
      decrease in restricted cash
    		                                                                 
      proceeds from employee stock purchases, exercise of stock options and warrants
    		                                            2,422,000   2,951,000 4,057,000                 
      payment of employee withholding taxes upon exercise of share-based awards
    		                                            0 0 -25,299,000                   
      payments of debt extinguishment costs
    		                                               -150,000                  
      net repayments under revolving credit facility
    		                                                                 
      other assets and liabilities
    		                                             -892,000 -299,000                   
      proceeds from exercise of stock options and warrants
    		                                              5,160,000    4,526,000               
      net repayments under revolving credit facilities
    		                                                -4,000,000 0 -3,350,000               
      stock-based compensation expense
    		                                               10,946,000 3,195,000 3,415,000 3,148,000 2,250,000 2,177,000 1,960,000 1,832,000 2,448,000 1,313,000 1,114,000 1,082,000 2,316,000 1,688,000 1,875,000 2,227,000 2,287,000 1,793,000 
      long-term debt, non-cash interest expense
    		                                               0 0 188,000 206,000 231,000              
      other assets
    		                                               -4,000 69,000    -101,000   -731,000 247,000 -517,000 -4,000 261,000 160,000 -269,000 -232,000 304,000 -266,000 
      deferred rent
    		                                               0 -12,000 -65,000 -5,000 -4,000 13,000 22,000 22,000 22,000        -85,000 -75,000 
      decrease (increase) in restricted cash
    		                                                                 
      proceeds from offerings of common stock, net of issuance costs
    		                                                                 
      proceeds from issuance of long-term debt
    		                                                                 
      net (repayments under) proceeds from revolving credit facilities
    		                                                                 
      supplemental disclosure of cash flow information:
    		                                                                 
      cash paid for interest
    		                                                             4,554,000 3,616,000   
      supplemental disclosure of non-cash investing and financing activities:
    		                                                                 
      liability for purchase of product rights
    		                                                       0 0         
      warrants to purchase common stock
    		                                                                 
      modification to warrants to purchase common stock issued in conjunction with long-term debt
    		                                                                 
      decrease in restricted cash and investments
    		                                                    510,000 41,000 2,037,000  125,000 -300,000 1,138,000       
      repayment of senior secured notes
    		                                                   0 0 -116,496,000 -3,000,000     0      
      proceeds from term loan
    		                                                   -261,000 0             
      repayment of term loan
    		                                                 -4,166,000 -4,166,000 -4,166,000              
      gain on sale of product rights
    		                                                           0    -715,000 0 
      decrease (increase) in restricted cash and investments
    		                                                           85,000 0 0 11,941,000 -1,550,000  
      transfer of restricted cash to marketable securities
    		                                                                 
      proceeds from sale of product rights
    		                                                           0    1,150,000 0 
      prepayment penalties and fees
    		                                                                 
      proceeds from employee stock purchases and exercise of stock options and warrants
    		                                                                 
      proceeds from sale of senior secured notes and warrants, net of issuance costs
    		                                                           -28,000 0 -634,000 39,200,000   
      modification to warrants to purchase common stock issued in conjunction with senior secured notes
    		                                                                 
      loss on extinguishment of debt, non-cash portion
    		                                                    0             
      proceeds from offering of common stock, net of issuance costs
    		                                                    -302,000             
      proceeds from private offerings, net of issuance costs
    		                                                                 
      proceeds from employee stock purchases and exercise of stock options
    		                                                    67,000   236,000 25,000   192,000 0     
      net repayment of revolving credit facilities
    		                                                    0             
      warrants to purchase common stock issued in conjunction with unregistered sales of equity securities
    		                                                       0          
      senior secured notes, non-cash interest expense
    		                                                     873,000 1,050,000  701,000         
      senior secured notes, accrued and unpaid interest
    		                                                                 
      proceeds from exercise of employee stock options
    		                                                      511,000           
      net repayment of revolving line of credit
    		                                                      -1,559,000           
      fair value adjustment to acquired finished goods
    		                                                               0 0 
      revaluation of preferred stock warrant liability
    		                                                               0 0 
      senior secured notes
    		                                                                 
      increase in restricted cash and investments
    		                                                                 
      net proceeds from line of credit
    		                                                                 
      warrants to purchase common stock issued in conjunction with registered direct public offering
    		                                                           0      
      warrants to purchase common stock issued in conjunction with senior secured notes
    		                                                           0 0     
      warrants to purchase common stock issued in conjunction with equity financing facility
    		                                                           0 0     
      purchases of product rights
    		                                                        -2,000,000         
      net repayments of line of credit
    		                                                                 
      proceeds from public offerings, net of issuance costs
    		                                                                 
      common stock issued as employee bonuses
    		                                                            0     
      accrued unpaid interest on senior secured notes
    		                                                                 
      benefit from government settlement
    		                                                         149,000 62,000    -1,818,000   
      net (repayments of) proceeds from line of credit
    		                                                                 
      accrued unpaid interest for senior secured notes
    		                                                          5,078,000       
      proceeds from exercise of stock options
    		                                                              2,000   
      repayment under line of credit
    		                                                          -3,875,000       
      interest on development financing
    		                                                                 
      gain on extinguishment of development financing
    		                                                                 
      proceeds from sale of property and equipment
    		                                                                 
      proceeds from maturites of long-term restricted cash equivalents
    		                                                                 
      proceeds from issuances of convertible preferred stock, net of issuance costs
    		                                                                 
      proceeds from line of credit
    		                                                             6,100,000 3,179,000 4,307,000 3,308,000 
      proceeds from development financing
    		                                                                 
      beneficial conversion feature - deemed dividend attributable to preferred stockholders
    		                                                                 
      •
    		                                                                 
      transfer of long-term restricted investments to marketable securities
    		                                                            0 0 -4,410,000   
      proceeds from sale of common stock in initial public offering, net of issuance costs
    		                                                                -650,000 
      net (repayments under) proceeds from line of credit
    		                                                                 
      proceeds from sale of common stock in registered direct public offering, net of issuance costs
    		                                                                 
      supplemental disclosure of non-cash financing and investing activities:
    		                                                                 
      conversion of preferred stock warrant liability to stockholders’ equity
    		                                                                0 
      purchased product rights liability
    		                                                                 
      1.
    		                                                                 
      purchase of developed technology
    		                                                             -10,000,000 -10,000,000   
      repayments under line of credit
    		                                                             -3,181,000 -3,458,000 -3,445,000 -3,845,000 
      supplemental disclosure of non-cash financing activities:
    		                                                                 
      fair value of warrants granted under 40.0 million senior notes
    		                                                              2,000,000   
      purchased in-process research and development
    		                                                                 
      purchases of available-for-sale securities
    		                                                                 
      proceeds from sales of available-for-sale securities
    		                                                                 
      proceeds from maturities of available-for-sale securities
    		                                                                 
      cash paid for shares of orphan medical, inc., net of cash acquired
    		                                                                 
      proceeds from maturites of long term restricted cash equivalents
    		                                                                 
      proceeds from initial public offering
    		                                                                 
      proceeds from sale of senior secured notes, net of issuance costs
    		                                                                 
      warrants to purchase series bb convertible preferred stock issued in conjuction with senior secured notes
    		                                                                 
      beneficial conversion feature—deemed dividend attributable to preferred stockholders
    		                                                                 
      depreciation and amortization
    		                                                                332,000 
      excess of cash paid over accrued for interest
    		                                                                315,000 
      gain on extinguishment of development financing obligation
    		                                                                 
      proceeds from issuances of common stock, net of issuance costs
    		                                                                0 
    The information provided in this report is taken from www.sec.gov and many other data providers. While we have conducted our best efforts to ensure that the parsed data is accurate, we cannot guarantee its accuracy. Please use caution and understand that any consequences of its use are your own responsibility.