7Baggers

iRhythm Technologies, Inc
(NASDAQ:IRTC) 

IRTC stock logo

iRhythm Technologies, Inc., a digital healthcare company, provides ambulatory electrocardiogram (ECG) monitoring products for patients at risk for arrhythmias in the United States. It offers Zio service, an ambulatory cardiac monitoring solution that combines a wire-free, patch-based, and wearable b...

Founded: 2008
Full Time Employees: 997
Sector: Healthcare
Industry: Medical Instruments & Supplies
Healthcare
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At a glance:
Bull Thesis:
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Moat:
Income Statements:
Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 
                                           
      revenue
    		199,390,000 208,890,000 192,884,000 186,687,000 158,677,000 164,325,000 147,538,000 148,047,000 131,929,000 132,511,000 124,604,000 124,130,000 111,436,000 112,617,000 103,875,000 102,051,000 92,378,000 81,804,000 85,432,000 81,278,000 74,311,000 78,809,000 71,944,000 50,878,000 63,535,000 59,104,000 54,673,000 53,331,000 47,214,000 43,155,000 38,104,000 35,469,000 30,565,000 28,182,000 25,035,000 23,854,000 21,437,000 18,704,000 16,780,000 
      yoy
    		25.66% 27.12% 30.74% 26.10% 20.27% 24.01% 18.41% 19.27% 18.39% 17.67% 19.96% 21.64% 20.63% 37.67% 21.59% 25.56% 24.31% 3.80% 18.75% 59.75% 16.96% 33.34% 31.59% -4.60% 34.57% 36.96% 43.48% 50.36% 54.47% 53.13% 52.20% 48.69% 42.58% 50.67% 49.20%     
      qoq
    		-4.55% 8.30% 3.32% 17.65% -3.44% 11.38% -0.34% 12.22% -0.44% 6.35% 0.38% 11.39% -1.05% 8.42% 1.79% 10.47% 12.93% -4.25% 5.11% 9.38% -5.71% 9.54% 41.40% -19.92% 7.50% 8.10% 2.52% 12.96% 9.41% 13.26% 7.43% 16.04% 8.46% 12.57% 4.95% 11.27% 14.61% 11.47%  
      cost of revenue
    		58,037,000 60,835,000 55,762,000 53,830,000 49,461,000 49,257,000 46,062,000 44,576,000 44,413,000 45,085,000 42,130,000 37,905,000 35,755,000 33,910,000 32,954,000 31,806,000 30,619,000 30,521,000 29,284,000 25,995,000 23,458,000 20,498,000 18,232,000 15,484,000 16,063,000 13,915,000 13,785,000 12,825,000 11,730,000 10,529,000 9,949,000 9,490,000 8,611,000 7,706,000 6,920,000 6,744,000 6,337,000 5,786,000 5,282,000 
      gross profit
    		141,353,000 148,055,000 137,122,000 132,857,000 109,216,000 115,068,000 101,476,000 103,471,000 87,516,000 87,426,000 82,474,000 86,225,000 75,681,000 78,707,000 70,921,000 70,245,000 61,759,000 51,283,000 56,148,000 55,283,000 50,853,000 58,311,000 53,712,000 35,394,000 47,472,000 45,189,000 40,888,000 40,506,000 35,484,000 32,626,000 28,155,000 25,979,000 21,954,000 20,476,000 18,115,000 17,110,000 15,100,000 12,918,000 11,498,000 
      yoy
    		29.43% 28.67% 35.13% 28.40% 24.80% 31.62% 23.04% 20.00% 15.64% 11.08% 16.29% 22.75% 22.54% 53.48% 26.31% 27.06% 21.45% -12.05% 4.54% 56.19% 7.12% 29.04% 31.36% -12.62% 33.78% 38.51% 45.22% 55.92% 61.63% 59.34% 55.42% 51.84% 45.39% 58.51% 57.55%     
      qoq
    		-4.53% 7.97% 3.21% 21.65% -5.09% 13.39% -1.93% 18.23% 0.10% 6.00% -4.35% 13.93% -3.84% 10.98% 0.96% 13.74% 20.43% -8.66% 1.56% 8.71% -12.79% 8.56% 51.75% -25.44% 5.05% 10.52% 0.94% 14.15% 8.76% 15.88% 8.38% 18.33% 7.22% 13.03% 5.87% 13.31% 16.89% 12.35%  
      gross margin %
    		70.89% 70.88% 71.09% 71.17% 68.83% 70.02% 68.78% 69.89% 66.34% 65.98% 66.19% 69.46% 67.91% 69.89% 68.28% 68.83% 66.85% 62.69% 65.72% 68.02% 68.43% 73.99% 74.66% 69.57% 74.72% 76.46% 74.79% 75.95% 75.16% 75.60% 73.89% 73.24% 71.83% 72.66% 72.36% 71.73% 70.44% 69.07% 68.52% 
      operating expenses:
    		                                       
      research and development
    		21,358,000 21,046,000 21,033,000 21,012,000 21,519,000 19,081,000 15,694,000 19,690,000 16,994,000 15,416,000 16,309,000 13,677,000 14,842,000 12,675,000 11,448,000 11,945,000 10,542,000 11,870,000 8,685,000 9,606,000 8,510,000 11,604,000 8,768,000 12,542,000 8,415,000 9,268,000 13,499,000 8,639,000 6,756,000 7,003,000 5,164,000 4,564,000 4,019,000 4,148,000 3,790,000 2,776,000 2,621,000 2,303,000 1,635,000 
      acquired in-process research and development
    		296,000 740,000 302,000 1,698,000 296,000 302,000 32,069,000                                 
      selling, general and administrative
    		135,884,000 122,004,000 124,216,000 126,376,000 119,957,000 99,768,000 103,375,000 106,762,000 108,660,000 100,114,000 93,768,000 91,420,000 100,343,000 86,730,000 80,559,000 81,751,000 73,158,000 71,612,000 70,745,000 62,669,000 69,813,000 56,288,000 49,701,000 43,014,000 48,230,000 53,647,000 45,649,000 43,189,000 36,705,000 37,172,000 32,739,000 33,094,000 28,577,000 26,950,000 20,308,000 20,255,000 17,224,000 14,963,000 12,529,000 
      total operating expenses
    		157,538,000 145,769,000 145,551,000 151,565,000 141,772,000 119,151,000 151,779,000 126,452,000 125,654,000 126,608,000 110,077,000 105,097,000 115,185,000 99,405,000 92,007,000 93,696,000 110,308,000 83,482,000 79,430,000 72,275,000 78,323,000 67,892,000 58,469,000 55,556,000 56,645,000 62,915,000 59,148,000 51,828,000 43,461,000 44,175,000 37,903,000 37,658,000 32,596,000 31,098,000 24,098,000 23,031,000 19,845,000 17,266,000 14,164,000 
      income from operations
    		-16,185,000 2,286,000 -8,429,000 -18,708,000 -32,556,000 -4,083,000 -50,303,000 -22,981,000 -38,138,000 -39,182,000 -27,603,000 -18,872,000 -39,504,000 -20,698,000 -21,086,000 -23,451,000 -48,549,000 -32,199,000 -23,282,000 -16,992,000 -27,470,000 -9,581,000 -4,757,000 -20,162,000 -9,173,000 -17,726,000 -18,260,000 -11,322,000 -7,977,000 -11,549,000 -9,748,000 -11,679,000 -10,642,000 -10,622,000 -5,983,000 -5,921,000 -4,745,000 -4,348,000 -2,666,000 
      yoy
    		-50.29% -155.99% -83.24% -18.59% -14.64% -89.58% 82.24% 21.77% -3.46% 89.30% 30.91% -19.53% -18.63% -35.72% -9.43% 38.01% 76.73% 236.07% 389.43% -15.72% 199.47% -45.95% -73.95% 78.08% 14.99% 53.49% 87.32% -3.06% -25.04% 8.73% 62.93% 97.25% 124.28% 144.30% 124.42%     
      qoq
    		-808.01% -127.12% -54.94% -42.54% 697.35% -91.88% 118.89% -39.74% -2.66% 41.95% 46.26% -52.23% 90.86% -1.84% -10.08% -51.70% 50.78% 38.30% 37.02% -38.14% 186.71% 101.41% -76.41% 119.80% -48.25% -2.92% 61.28% 41.93% -30.93% 18.48% -16.53% 9.74% 0.19% 77.54% 1.05% 24.78% 9.13% 63.09%  
      operating margin %
    		-8.12% 1.09% -4.37% -10.02% -20.52% -2.48% -34.09% -15.52% -28.91% -29.57% -22.15% -15.20% -35.45% -18.38% -20.30% -22.98% -52.55% -39.36% -27.25% -20.91% -36.97% -12.16% -6.61% -39.63% -14.44% -29.99% -33.40% -21.23% -16.90% -26.76% -25.58% -32.93% -34.82% -37.69% -23.90% -24.82% -22.13% -23.25% -15.89% 
      interest and other income, net:
    		                                       
      interest income
    		4,879,000 5,337,000 5,944,000 5,321,000 4,919,000 5,740,000 6,456,000                                 
      interest expense
    		-3,290,000 -3,322,000 -3,281,000 -3,278,000 -3,273,000 -3,320,000 -3,329,000 -3,312,000 -2,860,000 -941,000 -927,000 -832,000 -950,000 -1,013,000 -614,000 -482,000 -2,029,000 -248,000 -279,000 -307,000 -335,000 -374,000 -384,000 -381,000 -380,000 -385,000 -409,000 -440,000 -409,000 -535,000 -861,000 -861,000 -858,000 -864,000 -862,000 -839,000 -822,000 -860,000 -807,000 
      other income
    		1,163,000 1,725,000 578,000 2,264,000 875,000 481,000 1,182,000      1,432,000 1,586,000 365,000 69,000 16,000 15,000 -76,000 55,000 124,000 280,000 569,000 237,000 505,000 829,000 396,000 310,000 379,000 444,000 365,000 334,000 383,000 225,000 321,000 316,000 264,000 -253,750 -602,000 
      total interest and other income
    		2,752,000 3,740,000 3,241,000 4,307,000 2,521,000 2,901,000 4,309,000                                 
      income before income taxes
    		-13,433,000 6,026,000 -5,188,000 -14,401,000 -30,035,000 -1,182,000 -45,994,000 -19,913,000 -45,635,000 -38,444,000 -26,921,000 -18,269,000 -39,022,000 -20,125,000 -21,335,000 -23,864,000 -50,562,000 -32,432,000 -23,637,000 -17,244,000 -27,681,000 -9,675,000 -4,572,000 -20,306,000 -9,048,000 -17,282,000 -18,273,000 -11,452,000 -8,007,000           
      income tax provision
    		500,000 447,000 24,000 -183,000 665,000 151,000 188,000 194,000 32,000 255,000 195,000 213,000 87,000 73,000 116,000 33,000 47,000 59,000 94,000 116,000 98,000 -24,000 105,000 131,000 17,000 18,000 20,000 15,000 12,000           
      net income
    		-13,933,000 5,579,000 -5,212,000 -14,218,000 -30,700,000 -1,333,000 -46,182,000 -20,107,000 -45,667,000 -38,699,000 -27,116,000 -18,482,000 -39,109,000 -20,198,000 -21,451,000 -23,897,000 -50,609,000 -32,491,000 -23,731,000 -17,360,000 -27,779,000 -9,651,000 -4,677,000 -20,437,000 -9,065,000 -17,300,000 -18,293,000 -11,467,000 -8,019,000 -14,713,000 -10,244,000 -12,206,000 -11,117,000 -11,149,000 -6,524,000 -6,444,000 -5,303,000   
      yoy
    		-54.62% -518.53% -88.71% -29.29% -32.77% -96.56% 70.31% 8.79% 16.77% 91.60% 26.41% -22.66% -22.72% -37.84% -9.61% 37.66% 82.18% 236.66% 407.40% -15.06% 206.44% -44.21% -74.43% 78.22% 13.04% 17.58% 78.57% -6.05% -27.87% 31.97% 57.02% 89.42% 109.64%       
      qoq
    		-349.74% -207.04% -63.34% -53.69% 2203.08% -97.11% 129.68% -55.97% 18.01% 42.72% 46.72% -52.74% 93.63% -5.84% -10.24% -52.78% 55.76% 36.91% 36.70% -37.51% 187.84% 106.35% -77.12% 125.45% -47.60% -5.43% 59.53% 43.00% -45.50% 43.63% -16.07% 9.80% -0.29% 70.89% 1.24% 21.52%    
      net income margin %
    		-6.99% 2.67% -2.70% -7.62% -19.35% -0.81% -31.30% -13.58% -34.61% -29.20% -21.76% -14.89% -35.10% -17.94% -20.65% -23.42% -54.78% -39.72% -27.78% -21.36% -37.38% -12.25% -6.50% -40.17% -14.27% -29.27% -33.46% -21.50% -16.98% -34.09% -26.88% -34.41% -36.37% -39.56% -26.06% -27.01% -24.74% 0% 0% 
      net loss per common share, basic and diluted
    		-430 180 -160 -440 -970 -40 -1,480 -650 -1,470 -1,260 -890 -610 -1,290 -660 -710 -800 -1,710 -1,110 -810 -590 -950 -330 -170 -750 -340 -660 -720 -460 -330           
      weighted-average shares, basic and diluted
    		32,507,000 32,004,000 32,170,000 31,990,000 31,590,000 31,196,000 31,262,000 31,145,000 31,033,000 30,528,000 30,607,000 30,502,000 30,297,000 29,915,720,000 30,055,166,000 29,843,141,000 29,596,325,000 29,331,010,000 29,397,845,000 29,318,894,000 29,164,430,000 27,754,404,000 28,050,210,000 27,176,601,000 26,839,870,000 25,265,918,000 25,247,831,000 24,724,808,000 24,474,308,000 23,885,858,000 24,059,010,000 23,747,131,000 23,479,955,000       
      impairment charges
    		 1,979,000  2,479,000  160,250 641,000                                 
      loss on extinguishment of debt
    		        -7,589,000                               
      interest and other income
    		       6,380,000 2,952,000 1,679,000 1,609,000 1,435,000                            
      impairment and restructuring charges
    		                26,608,000                       
      net income per common share, basic and diluted
    		                             -352.5 -430 -510 -470 -202.5 -290 -290 -240 -2,550 -2,800 
      weighted-average shares used for eps calculation
    		                                  22,811,907,000 22,362,608,000 22,151,926,000  1,454,307,000 
      net income and comprehensive loss
    		                                     -3,659,250 -4,075,000 
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 
                                            
        assets
      		                                      
        current assets:
      		                                      
        cash and cash equivalents
      		240,146,000 255,605,000 309,105,000 375,278,000 419,597,000 519,535,000 550,552,000 520,421,000 36,173,000 47,478,000 61,578,000 52,804,000 78,832,000 71,222,000 101,253,000 94,786,000 127,562,000 167,371,000 138,872,000 137,375,000 88,628,000 95,336,000 81,730,000 56,514,000 20,462,000 34,634,000 16,154,000 28,235,000 20,023,000 17,345,000 19,241,000 16,473,000 8,671,000 20,429,000 16,249,000 15,583,000 51,643,000 5,761,000 
        marketable securities
      		309,474,000 309,608,000 236,435,000 145,311,000 115,956,000 2,496,000 10,905,000 48,671,000 97,591,000 110,995,000 103,161,000                            
        accounts receivable
      		80,863,000 76,157,000 82,153,000 80,639,000 79,941,000 77,427,000 85,513,000 89,712,000 61,484,000 50,067,000 51,108,000 49,557,000 49,918,000 60,534,000 57,380,000 55,286,000 46,430,000 52,820,000 63,423,000 59,982,000 29,932,000 28,955,000 22,877,000 24,211,000 23,867,000 25,003,000 29,137,000 28,252,000 21,977,000 20,465,000 19,065,000 17,165,000 12,953,000 12,039,000 10,851,000 10,982,000 9,406,000 9,308,000 
        inventory
      		23,800,000 19,559,000 18,399,000 14,336,000 14,039,000 15,032,000 15,425,000 14,873,000 13,973,000 13,648,000 14,478,000 16,388,000 15,155,000 14,452,000 14,422,000 12,446,000 10,268,000 9,960,000 9,261,000 6,863,000 5,313,000 5,062,000 4,989,000 4,227,000 4,037,000 3,499,000 2,774,000 2,504,000 2,062,000 2,320,000 2,168,000 1,857,000 1,683,000 1,314,000 1,231,000 1,156,000 1,390,000 1,672,000 
        prepaid expenses and other current assets
      		26,275,000 19,106,000 17,825,000 20,449,000 16,286,000 13,419,000 15,113,000 13,778,000 21,591,000 12,104,000 11,816,000 11,608,000 10,555,000 7,326,000 8,526,000 9,838,000 9,693,000 5,641,000 7,219,000 6,975,000 7,363,000 4,685,000 3,743,000 4,223,000 4,337,000 3,653,000 3,669,000 3,810,000 4,100,000 2,769,000 2,507,000 1,777,000 2,582,000 1,989,000 1,817,000 1,388,000 1,671,000 1,013,000 
        total current assets
      		680,558,000 680,035,000 663,917,000 636,013,000 645,819,000 627,909,000 677,508,000 687,455,000 230,812,000 234,292,000 242,141,000 253,890,000 288,772,000 285,850,000 284,819,000 286,354,000 305,522,000 325,188,000 335,567,000 336,106,000 377,825,000 365,939,000 146,535,000 154,431,000 172,792,000 184,880,000 94,974,000 93,308,000 106,482,000 106,731,000 109,656,000 111,542,000 119,581,000 122,788,000 123,817,000 106,597,000 118,608,000 17,845,000 
        property and equipment
      		156,704,000 149,316,000 139,703,000 130,850,000 125,092,000 122,390,000 117,572,000 112,274,000 104,114,000 96,668,000 89,845,000 82,208,000 75,670,000 71,515,000 65,923,000 57,135,000 55,944,000 53,429,000 47,086,000 37,447,000 34,247,000 32,775,000 30,199,000 28,454,000 26,464,000 17,803,000 12,618,000 10,208,000 9,158,000 8,250,000 7,560,000 6,860,000 6,221,000 6,207,000 6,166,000 5,529,000 4,653,000 3,363,000 
        operating lease right-of-use assets
      		40,324,000 43,300,000 44,749,000 46,171,000 47,564,000 45,570,000 46,833,000 48,073,000 49,317,000 60,899,000 57,917,000 59,301,000 60,666,000 62,010,000 63,940,000 65,256,000 84,587,000 86,116,000 87,533,000 89,206,000 84,714,000 86,247,000 87,758,000 89,249,000 90,124,000 91,935,000 94,326,000 9,232,000           
        restricted cash
      		8,358,000 8,358,000 8,358,000 8,358,000 8,358,000                              91,000 91,000 91,000 91,000 
        goodwill
      		862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 862,000 
        long-term strategic investments
      		72,860,000 68,091,000 64,897,000 62,745,000 61,902,000 59,059,000                                 
        other assets
      		46,699,000 45,252,000 41,544,000 41,099,000 41,852,000 45,540,000 68,052,000 52,733,000 48,039,000 47,048,000 38,723,000 25,440,000 22,252,000 20,153,000 20,142,000 19,110,000 16,052,000 14,655,000 14,176,000 14,866,000 14,091,000 11,378,000 10,870,000 9,944,000 7,940,000 5,574,000 4,515,000 3,574,000 3,208,000 3,146,000 2,840,000 3,057,000 3,465,000 3,798,000 3,531,000 3,384,000 3,052,000 5,310,000 
        total assets
      		1,006,365,000 995,214,000 964,030,000 926,098,000 931,449,000 909,688,000 919,185,000 909,755,000 433,144,000 439,769,000 429,488,000 421,701,000 448,222,000 440,390,000 435,686,000 428,717,000 462,967,000 480,250,000 485,224,000 478,487,000 511,739,000 497,201,000 276,224,000 282,940,000 306,212,000 310,080,000 207,295,000 117,184,000 119,710,000 118,989,000 120,918,000 122,321,000 133,123,000 133,655,000 134,376,000 132,801,000 138,156,000 27,380,000 
        liabilities and stockholders’ equity
      		                                      
        current liabilities:
      		                                      
        accounts payable
      		8,559,000 8,278,000 12,775,000 11,946,000 7,221,000 7,593,000 13,425,000 8,440,000 5,543,000 7,212,000 7,150,000 9,778,000 7,517,000 7,404,000 5,987,000 5,413,000 10,509,000 4,893,000 8,945,000 5,152,000 4,365,000 3,838,000 5,012,000 5,544,000 8,243,000 4,187,000 3,628,000 1,960,000 2,284,000 1,911,000 2,658,000 1,525,000 2,395,000 2,076,000 2,658,000 1,413,000 2,103,000 1,581,000 
        accrued liabilities
      		102,342,000 117,882,000 99,577,000 79,976,000 84,900,000 73,958,000 65,940,000 70,044,000 83,362,000 76,631,000 64,469,000 54,607,000 65,497,000 60,264,000 49,954,000 41,935,000 51,486,000 53,141,000 42,598,000 36,260,000 40,532,000 32,185,000 25,170,000 23,247,000 32,586,000 32,227,000 23,304,000 20,099,000 26,570,000 19,178,000 16,355,000 12,658,000 15,644,000 11,436,000 9,985,000 8,284,000 10,165,000 6,894,000 
        deferred revenue
      		4,056,000 4,224,000 3,499,000 3,282,000 2,932,000 3,031,000 3,146,000 3,068,000 3,306,000 3,383,000 3,695,000 3,486,000 3,051,000 3,003,000 2,977,000 2,933,000 3,049,000 2,374,000 2,507,000 1,425,000 930,000 938,000 1,197,000 1,115,000 1,251,000 889,000 1,199,000 1,309,000 1,243,000 1,174,000 642,000 1,099,000 1,238,000 904,000 557,000 980,000 947,000 850,000 
        operating lease liabilities, current portion
      		16,793,000 16,526,000 16,360,000 16,140,000 15,867,000 15,522,000 15,384,000 15,289,000 15,159,000 15,065,000 14,099,000 14,032,000  12,920,000 11,498,000 11,501,000 11,142,000 10,707,000 7,301,000 4,878,000 8,171,000 8,211,000 8,157,000 8,078,000 7,914,000 8,036,000 7,384,000 5,052,000           
        total current liabilities
      		131,750,000 146,910,000 132,211,000 111,344,000 110,920,000 100,104,000 97,895,000 96,841,000 107,370,000 102,291,000 89,413,000 81,903,000 89,096,000 83,591,000 70,416,000 61,782,000 87,853,000 82,782,000 73,018,000 59,382,000 65,665,000 55,866,000 47,314,000 42,845,000 52,066,000 45,467,000 35,654,000 28,549,000 30,236,000 22,263,000 19,655,000 16,938,000 20,918,000 16,044,000 15,196,000 10,677,000 13,215,000 9,325,000 
        long-term senior convertible notes
      		650,313,000 648,753,000 648,007,000 647,237,000 646,443,000 645,821,000 644,977,000 644,076,000                               
        other noncurrent liabilities
      		907,000 9,926,000 9,775,000 8,727,000 8,579,000 17,978,000 940,000 908,000 1,012,000 1,013,000 1,012,000 1,013,000 1,307,000 1,163,000 952,000 832,000 697,000 2,432,000 2,265,000 1,836,000 1,830,000                  
        operating lease liabilities, noncurrent portion
      		62,185,000 67,732,000 70,377,000 72,125,000 74,599,000 74,019,000 76,184,000 77,640,000 79,715,000 81,724,000 80,242,000 82,012,000  81,481,000 84,749,000 86,344,000 85,212,000 86,593,000 87,984,000 89,270,000 81,293,000 82,537,000 83,800,000 85,042,000 85,748,000 87,099,000 88,106,000 3,990,000           
        total liabilities
      		845,155,000 873,321,000 860,370,000 839,433,000 840,541,000 837,922,000 819,996,000 819,465,000 223,047,000 219,974,000 205,609,000 199,867,000 208,410,000 201,166,000 191,044,000 183,875,000 183,452,000 184,410,000 178,782,000 168,915,000 170,127,000 162,655,000 158,278,000 157,963,000 170,803,000 167,495,000 158,687,000 67,461,000 65,288,000 55,031,000 52,451,000 49,698,000 53,570,000 48,266,000 46,950,000 43,489,000 45,594,000 45,212,000 
        commitments and contingencies
      		                                      
        stockholders’ equity:
      		                                      
        preferred stock, 0.001 par value – 5,000 shares authorized; none issued and outstanding at march 31, 2026 and december 31, 2025
      		                                      
        common stock
      		33,000 32,000 32,000 32,000 31,000 31,000 31,000 31,000 31,000 31,000 30,000 30,000 28,000    27,000 27,000 27,000 27,000 27,000 27,000 25,000 25,000 25,000 25,000 23,000 24,000 23,000 23,000 23,000 23,000 23,000 28,000 27,000 27,000 22,000 1,000 
        additional paid-in capital
      		1,003,514,000 955,601,000 932,467,000 901,085,000 874,607,000 854,363,000 835,356,000 806,621,000 855,784,000 826,686,000 803,792,000 783,182,000 762,380,000 741,879,000 725,748,000 701,822,000 685,594,000 669,373,000 656,231,000 641,996,000 646,258,000 629,484,000 408,096,000 394,507,000 395,695,000 385,614,000 271,551,000 261,231,000 257,955,000 252,765,000 247,039,000 239,037,000 236,184,000 230,831,000 226,365,000 221,776,000 219,718,000 5,974,000 
        accumulated other comprehensive income
      		42,000 285,000 -26,000 143,000 165,000  182,000      -396,000   -353,000 -61,000 -6,000 7,000 12,000 11,000 68,000 181,000 364,000 82,000 39,000 35,000 2,000           
        accumulated deficit
      		-817,379,000 -809,025,000 -803,813,000 -789,595,000 -758,895,000 -757,562,000 -711,380,000 -691,273,000 -645,606,000 -606,907,000 -579,791,000 -561,309,000 -522,200,000 -502,002,000 -480,551,000 -456,654,000 -406,045,000 -373,554,000 -349,823,000 -332,463,000 -304,684,000 -295,033,000 -290,356,000 -269,919,000 -260,393,000 -243,093,000 -223,001,000 -211,534,000 -203,515,000 -188,801,000 -178,557,000 -166,352,000 -156,589,000 -145,440,000 -138,916,000 -132,472,000 -127,169,000 -120,903,000 
        treasury stock
      		-25,000,000 -25,000,000 -25,000,000 -25,000,000 -25,000,000 -25,000,000 -25,000,000 -25,000,000                               
        total stockholders’ equity
      		161,210,000 121,893,000 103,660,000 86,665,000 90,908,000 71,766,000 99,189,000 90,290,000 210,097,000 219,795,000 223,879,000 221,834,000 239,812,000 239,224,000 244,642,000 244,842,000 279,515,000 295,840,000 306,442,000 309,572,000 341,612,000 334,546,000 117,946,000 124,977,000 135,409,000 142,585,000 48,608,000 49,723,000 54,422,000 63,958,000 68,467,000 72,623,000 79,553,000 85,389,000 87,426,000 89,312,000 92,562,000  
        total liabilities and stockholders’ equity
      		1,006,365,000 995,214,000 964,030,000 926,098,000 931,449,000 909,688,000 919,185,000 909,755,000 433,144,000 439,769,000 429,488,000 421,701,000 448,222,000 440,390,000 435,686,000 428,717,000 462,967,000 480,250,000 485,224,000 478,487,000 511,739,000 497,201,000 276,224,000 282,940,000 306,212,000 310,080,000 207,295,000 117,184,000 119,710,000     133,655,000 134,376,000    
        preferred stock, 0.001 par value – 5,000 shares authorized; none issued and outstanding at september 30, 2025 and december 31, 2024
      		                                      
        preferred stock, 0.001 par value – 5,000 shares authorized; none issued and outstanding at june 30, 2025 and december 31, 2024
      		                                      
        preferred stock, 0.001 par value – 5,000 shares authorized; none issued and outstanding at march 31, 2025 and december 31, 2024
      		                                      
        debt, noncurrent portion
      		        34,950,000 34,946,000 34,942,000 34,939,000  34,931,000 34,927,000 34,917,000 9,690,000 12,603,000 15,515,000 18,427,000 21,339,000 24,252,000 27,164,000 30,076,000 32,989,000              
        preferred stock, 0.001 par value – 5,000 shares authorized; none issued and outstanding at december 31, 2024 and 2023
      		                                      
        restricted cash, long-term
      		     8,358,000 8,358,000 8,358,000                               
        preferred stock, 0.001 par value – 5,000 shares authorized; none issued and outstanding at september 30, 2024 and december 31, 2023
      		                                      
        accumulated other comprehensive loss
      		     -66,000  -89,000 -112,000 -15,000 -152,000 -69,000  -681,000 -583,000              -41,000 -29,000 -38,000 -85,000 -65,000 -30,000 -50,000 -19,000 -9,000  
        preferred stock, 0.001 par value – 5,000 shares authorized; none issued and outstanding at june 30, 2024 and december 31, 2023
      		                                      
        preferred stock, 0.001 par value – 5,000 shares authorized; none issued and outstanding at march 31, 2024 and december 31, 2023
      		                                      
        preferred stock, 0.001 par value – 5,000 shares authorized; none issued and outstanding at december 31, 2023 and 2022
      		                                      
        preferred stock, 0.001 par value - 5,000 shares authorized; none issued and outstanding at september 30, 2023 and december 31, 2022
      		                                      
        preferred stock, 0.001 par value - 5,000 shares authorized; none issued and outstanding at june 30, 2023 and december 31, 2022
      		                                      
        short-term investments
      		           123,533,000 134,312,000 132,316,000 103,238,000 113,998,000 111,569,000 89,396,000 116,792,000 124,911,000 246,589,000 231,901,000 33,196,000 65,256,000 120,089,000 118,091,000 43,240,000 30,507,000 58,320,000 63,832,000 66,675,000 74,270,000 93,692,000    54,407,000  
        preferred stock, 0.001 par value - 5,000 shares authorized; none issued and outstanding at march 31, 2023 and december 31, 2022
      		                                      
        debt, current
      		                                      
        operating lease liabilities, current
      		            13,031,000                          
        debt, noncurrent
      		            34,935,000                          
        operating lease liabilities, noncurrent
      		            83,072,000                          
        preferred stock, 0.001 par value – 5,000,000 shares authorized at december 31, 2022 and 2021; and none issued and outstanding at december 31, 2022 and 2021, respectively
      		                                      
        debt, current portion
      		                11,667,000 11,667,000 11,667,000 11,667,000 11,667,000 10,694,000 7,778,000 4,861,000 1,944,000       1,495,000 1,487,000 1,479,000 1,471,000    
        preferred stock, 0.001 par value...
      		                                      
        common stock, 0.001 par value...
      		             28,000 28,000 27,000                       
        preferred stock, 0.001 par value – 5,000,000 shares authorized at december 31, 2021 and 2020; and none issued and outstanding at december 31, 2021 and 2020, respectively
      		                                      
        preferred stock, 0.001 par value – 5,000,000 shares authorized at september 30, 2021 and december 31, 2020; and none issued and outstanding
      		                                      
        preferred stock, 0.001 par value – 5,000,000 shares authorized at june 30, 2021 and december 31, 2020; and none issued and outstanding at june 30, 2021 and december 31, 2020
      		                                      
        preferred stock, 0.001 par value – 5,000,000 shares authorized at march 31, 2021 and december 31, 2020; and none issued and outstanding at march 31, 2021 and december 31, 2020
      		                                      
        long-term investments
      		                        8,030,000 9,026,000             
        preferred stock, 0.001 par value – 5,000,000 shares authorized at december 31, 2020 and 2019; and none issued and outstanding at december 31, 2020 and 2019, respectively
      		                                      
        preferred stock, 0.001 par value – 5,000,000 shares authorized at september 30, 2020 and december 31, 2019; and none issued and outstanding at september 30, 2020 and december 31, 2019
      		                                      
        preferred stock, 0.001 par value – 5,000,000 shares authorized at june 30, 2020 and december 31, 2019; and none issued and outstanding at june 30, 2020 and december 31, 2019
      		                                      
        preferred stock, 0.001 par value – 5,000,000 shares authorized at march 31, 2020 and december 31, 2019; and none issued and outstanding at march 31, 2020 and december 31, 2019
      		                                      
        accrued interest
      		                        128,000 128,000             
        deferred rent, noncurrent portion
      		                            153,000 214,000 222,000 227,000 161,000 169,000 140,000 26,000 26,000 27,000 
        preferred stock, 0.001 par value – 5,000,000 shares authorized at december 31, 2019 and 2018; and none issued and outstanding at december 31, 2019 and 2018, respectively
      		                                      
        debt
      		                         34,929,000 34,927,000 34,922,000 34,899,000 32,554,000 32,574,000 32,533,000 32,491,000 32,053,000 31,614,000 32,652,000 32,227,000 31,796,000 
        preferred stock, 0.001 par value – 5,000,000 shares authorized at september 30, 2019 and december 31, 2018; and none issued and outstanding at september 30, 2019 and december 31, 2018
      		                                      
        accrued interest, current portion
      		                          139,000 129,000 139,000   161,000 154,000 149,000 525,000    
        preferred stock, 0.001 par value – 5,000,000 shares authorized at june 30, 2019 and december 31, 2018; and none issued and outstanding at june 30, 2019 and december 31, 2018
      		                                      
        preferred stock, 0.001 par value – 5,000,000 shares authorized at march 31, 2019 and december 31, 2018; and none issued and outstanding at march 31, 2019 and december 31, 2018
      		                                      
        investments, long-term
      		                                2,994,000   16,429,000 10,981,000  
        preferred stock, 0.001 par value – 5,000,000 shares authorized at december 31, 2018 and 2017; and none issued and outstanding at december 31, 2018 and 2017, respectively
      		                                      
        preferred stock, 0.001 par value – 5,000,000 authorized at september 30, 2018 and december 31, 2017, respectively; and none issued and outstanding at september 30, 2018 and december 31, 2017, respectively
      		                                      
        total liabilities, preferred stock and stockholders’ equity
      		                             118,989,000 120,918,000 122,321,000 133,123,000      
        preferred stock, 0.001 par value – 5,000,000 authorized at june 30, 2018 and december 31, 2017, respectively; and none issued and outstanding at june 30, 2018 and december 31, 2017, respectively
      		                                      
        preferred stock, 0.001 par value – 5,000,000 authorized at march 31, 2018 and december 31, 2017, respectively; and none issued and outstanding at march 31, 2018 and december 31, 2017, respectively
      		                                      
        liabilities, and stockholders’ equity
      		                                      
        accrued interest, net of current portion
      		                                   134,000 126,000 119,000 
        preferred stock, 0.001 par value – 5,000,000 shares authorized at december 31, 2017 and 2016, respectively; and none issued and outstanding at december 31, 2017 and 2016, respectively
      		                                      
        investments, short-term
      		                                 87,017,000 93,578,000 77,397,000   
        preferred stock, 0.001 par value – 5,000,000 authorized at september 30, 2017 and december 31, 2016, respectively; and none issued and outstanding at september 30, 2017 and december 31, 2016, respectively
      		                                      
        preferred stock, 0.001 par value – 5,000,000 authorized at june 30, 2017 and december 31, 2016, respectively; and none issued and outstanding at june 30, 2017 and december 31, 2016, respectively
      		                                      
        stockholders’ deficit:
      		                                      
        preferred stock, 0.001 par value – 5,000,000 authorized at march 31, 2017 and december 31, 2016, respectively; and none issued and outstanding at march 31, 2017 and december 31, 2016, respectively
      		                                      
        total liabilities, stockholders’ equity
      		                                   132,801,000   
        liabilities, convertible preferred stock and stockholders’ equity
      		                                      
        preferred stock warrant liabilities
      		                                     3,945,000 
        convertible preferred stock, 0.001 par value – zero and 11,392,882 shares authorized at december 31, 2016 and 2015, respectively; zero and 11,046,146 shares issued and outstanding at december 31, 2016 and 2015, respectively; aggregate liquidation preference of 0, and 117,495 at december 31, 2016 and 2015, respectively
      		                                      
        stockholders’ equity
      		                                      
        preferred stock, 0.001 par value – 5,000,000 and zero shares authorized at december 31, 2016 and 2015, respectively; and none issued and outstanding at december 31, 2016 and 2015, respectively
      		                                      
        total liabilities, convertible preferred stock and stockholders’ equity
      		                                    138,156,000  
        liabilities, convertible preferred stock and stockholders’ deficit
      		                                      
        convertible preferred stock, 0.001 par value – 11,392,882 and 11,392,882 shares authorized at september 30, 2016 and december 31, 2015, respectively; 11,046,146 and 11,046,146 shares issued and outstanding at september 30, 2016 and december 31, 2015, respectively; aggregate liquidation preference of 117,495, and 117,495 at september 30, 2016 and december 31, 2015, respectively
      		                                     97,096,000 
        total stockholders’ deficit
      		                                     -114,928,000 
        total liabilities, convertible preferred stock and stockholders’ deficit
      		                                     27,380,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 
                                             
          cash flows from operating activities
        		                                     
          net loss
        		-13,933,000 -5,212,000 -14,218,000 -30,700,000  -46,182,000 -20,107,000 -45,667,000 -38,699,000 -27,116,000 -18,482,000 -39,109,000  -21,451,000 -23,897,000 -50,609,000 -32,491,000 -23,731,000 -17,360,000 -27,779,000 -9,651,000 -4,677,000 -20,437,000 -9,065,000 -17,300,000 -17,782,000 -11,467,000 -8,019,000 -14,713,000 -10,244,000 -12,206,000 -11,117,000 -11,149,000 -6,524,000 -6,444,000 -5,303,000 -6,266,000 
          adjustments to reconcile net loss to net cash from operating activities:
        		                                     
          depreciation and amortization
        		5,042,000 5,173,000 5,105,000 5,210,000 5,289,000 5,135,000 5,160,000 5,131,000 4,914,000 4,067,000 3,791,000 3,576,000 3,475,000 3,436,000 3,351,000 3,143,000 3,104,000 2,549,000 2,153,000 2,036,000 1,978,000 1,702,000 1,669,000 1,551,000 1,188,000 965,000 671,000 621,000 596,000 568,000 557,000 548,000 494,000 468,000 337,000 298,000 -78,000 
          stock-based compensation
        		21,491,000 21,006,000 22,827,000 23,344,000 16,008,000 17,158,000 21,821,000 20,991,000 23,846,000 21,008,000 14,099,000 18,251,000 15,794,000 12,945,000 15,098,000 13,903,000 11,876,000 12,161,000 10,260,000 20,230,000 13,998,000 17,444,000 9,768,000 305,000 7,177,000 7,319,000 7,330,000 4,415,000 4,795,000 4,211,000 4,076,000 3,247,000 3,099,000 2,732,000 2,264,000 2,028,000 620,000 
          amortization of premium and accretion of discounts
        		-730,000 -892,000 -654,000 -619,000 -114,000 -87,000 -241,000 -908,000 -1,413,000 -1,416,000                            
          amortization of operating lease right-of-use assets
        		1,503,000 1,448,000 1,423,000 1,393,000 1,315,000 1,263,000 1,240,000 1,244,000 1,553,000 1,494,000 1,384,000 1,365,000 1,339,000 -2,998,000 1,316,000 6,547,000  1,814,000 1,672,000 1,555,000  1,511,000 1,491,000 1,495,000  2,391,000 3,878,000 1,183,000          
          amortization of debt discount
        		809,000 746,000 770,000 794,000 623,000 843,000 752,000 578,000                              
          change in fair value of strategic investments
        		-1,447,000 -894,000 -2,152,000 -843,000 -843,000                                 
          provision for credit losses and contractual allowances
        		27,844,000 25,457,000 25,277,000 29,427,000  17,251,000                                
          acquired in-process research and development
        		296,000 302,000 1,698,000 296,000 302,000                                 
          other
        		340,000 790,000 69,000 103,000 215,000 -179,000 290,000 106,000 703,000 -507,000 -35,000 176,000 34,000 3,000                        
          changes in operating assets and liabilities:
        		                                     
          accounts receivable
        		-33,000,000 -19,461,000 -26,791,000 -30,125,000 -23,240,000 -9,164,000 -14,998,000 -44,518,000 -29,389,000 -13,128,000 -17,612,000 -21,064,000 -3,955,000 -17,683,000 -17,321,000 -22,878,000 -6,749,000 848,000 -7,853,000 -39,818,000 -11,957,000 -13,006,000 -3,005,000 -9,989,000 -5,930,000 -4,951,000 -6,860,000 -10,984,000 -7,797,000 -3,891,000 -5,661,000 -5,536,000 -4,390,000 -2,898,000 -2,314,000 -3,348,000 -1,400,000 
          inventory
        		-2,424,000 -1,849,000 -4,213,000 -388,000 817,000 425,000 -543,000 -923,000 -906,000 1,340,000 1,949,000 -1,404,000 -733,000 -29,000 -1,969,000 -2,377,000 -317,000 -616,000 -2,419,000 -1,608,000 -330,000 -44,000 -824,000 -191,000 -538,000 -724,000 -270,000 -442,000 257,000 -152,000 -311,000 -174,000 -369,000 -83,000 -75,000 234,000 282,000 
          prepaid expenses and other current assets
        		-4,613,000 -1,276,000 2,624,000 -4,165,000 -2,860,000 1,687,000 -1,335,000 7,813,000 -9,487,000 -289,000 -207,000 -1,053,000 -3,229,000 1,200,000 1,313,000 -146,000 -4,051,000 1,577,000 -242,000 387,000 -2,680,000 -939,000 478,000 114,000 -684,000 15,000 142,000 -169,000 -1,337,000 -277,000 -744,000 790,000 -598,000 -172,000 -428,000 403,000 -658,000 
          other assets
        		-1,981,000 -3,708,000 -446,000 729,000 3,835,000 4,392,000 -312,000 -4,694,000 -991,000 -8,325,000 -10,282,000 -3,189,000 -2,101,000 -9,000 -1,032,000 -3,058,000 -1,358,000 -444,000 746,000 -775,000 -2,711,000 -710,000 -726,000 -2,002,000 -2,366,000 -1,192,000 -809,000 -365,000 -50,000 -306,000 216,000 409,000 326,000 -285,000 -162,000 -346,000 -393,000 
          accounts payable and accrued liabilities
        		-22,522,000 15,007,000 15,171,000 -489,000 971,000 2,302,000 2,196,000 -12,877,000                              
          deferred revenue
        		-145,000 725,000 217,000 350,000 -99,000 -115,000 78,000 -238,000 -77,000 -312,000 209,000 435,000 48,000 27,000 43,000 -116,000 675,000 -133,000 1,082,000 495,000 -8,000 -259,000 82,000 -136,000 362,000 -289,000 -111,000 66,000 69,000 532,000 -457,000 -139,000 334,000 347,000 -423,000 33,000 97,000 
          operating lease liabilities
        		-2,703,000 -2,479,000 -1,527,000 -2,208,000 -2,380,000 -2,033,000 -1,358,000 -1,945,000 -1,797,000 -2,031,000 -1,702,000 -59,000 -1,571,000 3,081,000 -1,598,000 -6,175,000 1,223,000 1,617,000 -1,212,000 -1,364,000 -1,284,000 -1,209,000 -1,163,000 -1,163,000 -1,162,000 -355,000 -2,524,000 -1,200,000          
          net cash from operating activities
        		-26,173,000 34,883,000 27,659,000 -7,891,000 19,232,000 24,347,000 11,840,000 -52,029,000 -15,972,000 1,196,000 -4,572,000 -30,753,000 12,576,000 3,669,000 -372,000 -38,885,000 -13,045,000 17,677,000 -543,000 -41,842,000 7,818,000 10,942,000 -10,153,000 -22,366,000 -4,860,000 -222,000 318,000 -17,099,000 -4,348,000 -5,097,000 -6,363,000 -13,260,000 -3,723,000 -3,788,000 -1,001,000 -6,399,000 -1,034,000 
          capital expenditures
        		-6,905,000 -14,831,000 -10,369,000 -9,419,000 -6,844,000 -8,834,000 -8,488,000 -9,776,000 -13,517,000 -9,087,000 -9,397,000 -8,423,000 -7,093,000 -6,333,000 -10,832,000 -5,572,000 -4,625,000 -13,308,000 -5,923,000 -4,211,000 -2,364,000 -5,601,000 -2,181,000 -3,405,000 -11,817,000 -4,172,000 -2,833,000 -1,635,000 -1,493,000 -1,461,000 -1,118,000 -1,108,000 -911,000 -531,000 -946,000 -1,174,000 -942,000 
          free cash flows
        		-33,078,000 20,052,000 17,290,000 -17,310,000 12,388,000 15,513,000 3,352,000 -61,805,000 -29,489,000 -7,891,000 -13,969,000 -39,176,000 5,483,000 -2,664,000 -11,204,000 -44,457,000 -17,670,000 4,369,000 -6,466,000 -46,053,000 5,454,000 5,341,000 -12,334,000 -25,771,000 -16,677,000 -4,394,000 -2,515,000 -18,734,000 -5,841,000 -6,558,000 -7,481,000 -14,368,000 -4,634,000 -4,319,000 -1,947,000 -7,573,000 -1,976,000 
          cash flows from investing activities
        		                                     
          purchases of property and equipment
        		-6,905,000 -14,831,000 -10,369,000 -9,419,000 -6,844,000 -8,834,000 -8,488,000 -9,776,000 -13,517,000 -9,087,000 -9,397,000 -8,423,000 -7,093,000 -6,333,000 -10,832,000 -5,572,000 -4,625,000 -13,308,000 -5,923,000 -4,211,000 -2,364,000 -5,601,000 -2,181,000 -3,405,000 -11,817,000 -4,172,000 -2,833,000 -1,635,000 -1,493,000 -1,461,000 -1,118,000 -1,108,000 -911,000 -531,000 -946,000 -1,174,000 -942,000 
          purchases of marketable securities
        		-94,030,000 -171,073,000 -135,146,000 -34,320,000 -115,815,000 0 0 -2,426,000 -55,083,000 -36,351,000                            
          maturities of marketable securities
        		132,650,000 99,000,000 44,600,000 5,600,000 2,500,000 8,500,000 38,000,000 52,200,000 70,000,000 30,000,000                            
          purchases of strategic investments
        		-1,500,000    -2,000,000 -40,000,000                                
          net cash from investing activities
        		30,215,000 -89,204,000 -100,915,000 -38,139,000 -122,159,000 -55,334,000 14,512,000 39,998,000 1,400,000 -15,438,000 9,009,000 3,820,000 -8,114,000 -35,362,000 -431,000 -8,527,000 -27,133,000 13,660,000 1,702,000 117,035,000 -17,485,000 -204,481,000 29,664,000 59,911,000 -12,508,000 -87,872,000 -15,343,000 26,449,000 4,269,000 1,686,000 6,703,000 21,459,000 -10,472,000 6,233,000 -658,000 -29,696,000 -66,345,000 
          cash flows from financing activities
        		                                     
          proceeds from issuance of common stock in connection with employee equity incentive plans
        		149,000 825,000 7,094,000 1,729,000 2,987,000 148,000 4,734,000 604,000 3,468,000 66,000 4,381,000 905,000 3,148,000 1,662,000 7,296,000 1,076,000 3,286,000 80,000 4,001,000 1,576,000 6,562,000                 
          net cash from financing activities
        		149,000 825,000 7,094,000 1,729,000 2,987,000 -35,000 3,788,000 504,641,000 3,468,000 66,000 4,381,000 905,000 3,148,000 1,662,000 7,270,000 14,636,000 369,000 -2,838,000 338,000 -26,446,000 2,959,000 207,145,000 5,705,000 -1,493,000 3,196,000 106,574,000 2,944,000 -1,138,000 2,757,000 1,515,000 2,428,000 -397,000 2,437,000 1,735,000 2,325,000 35,000 113,261,000 
          effect of exchange rate changes
        		-57,000 -4,000 -11,000 -18,000     -201,000 76,000                            
          net increase in cash, cash equivalents and restricted cash
        		4,134,000 -53,500,000 -66,173,000 -44,319,000                                  
          cash, cash equivalents and restricted cash, beginning of period
        		244,370,000 0 0 427,955,000                                  
          cash, cash equivalents and restricted cash, end of period
        		248,504,000 -53,500,000 -66,173,000 383,636,000                                  
          loss on extinguishment of debt
        		    0 0 0 7,589,000                              
          impairment charges
        		 0   0        0 0 0 23,164,000                      
          purchases of acquired in-process research and development
        		                                     
          payment of svb term loan and termination costs
        		    0 0 0 -37,751,000                              
          proceeds from braidwell debt
        		    0 0 0 75,000,000                              
          payments of issuance costs for braidwell debt
        		    0 0 -297,000 -1,803,000                              
          payment of braidwell debt and termination costs
        		    0 0 0 -78,660,000                              
          proceeds from issuance of 2029 notes
        		    0 0 0 661,250,000                              
          payments of issuance costs for 2029 notes
        		    0 -183,000 -649,000 -16,592,000                              
          purchases of capped call transactions
        		    0 0 0 -72,407,000                              
          purchase of treasury stock
        		    0 0 0 -25,000,000                              
          net income
        		                                     
          adjustments to reconcile net income to net cash from operating activities:
        		                                     
          benefit from credit losses and contractual allowances
        		                                     
          sales of marketable securities
        		                                     
          purchase of acquired in-process research and development
        		                                     
          proceeds from svb term loan
        		                                     
          net increase in cash and cash equivalents
        		            7,610,000 -30,031,000 6,467,000 -32,776,000 -39,809,000 28,499,000 1,497,000 48,747,000 -6,708,000 13,606,000 25,216,000 36,052,000 -14,172,000    2,678,000 -1,896,000 2,768,000 7,802,000      
          cash and cash equivalents, beginning of year
        		                                     
          cash and cash equivalents, end of year
        		                                     
          effect of exchange rate changes on cash
        		     5,000 -9,000 -4,000                              
          net increase in cash, cash equivalents, and restricted cash
        		     -31,017,000 30,131,000 492,606,000                   -12,081,000 8,212,000          
          cash, cash equivalents, and restricted cash, beginning of period
        		     0 0 36,173,000                              
          cash, cash equivalents, and restricted cash, end of period
        		     -31,017,000 30,131,000 528,779,000                              
          supplemental disclosures of cash flow information:
        		                                     
          interest paid
        		      0 1,595,000 774,000 769,000 739,000 678,000 641,000 462,000 247,000 1,967,000 251,000 285,000 327,000 331,000 370,000 336,000 402,000 394,000 398,000 410,000 425,000 411,000 3,513,000 804,000 961,000 787,000 398,000 777,000 0 375,000 378,000 
          cash taxes paid
        		      349,000 11,000 336,000 506,000 280,000 8,000                          
          cash received from tenant improvement allowances
        		        0 0 0 1,603,000                          
          non-cash investing and financing activities:
        		                                     
          property and equipment costs included in accounts payable and accrued liabilities
        		      210,000 23,000    203,000 -1,019,000   225,000  -5,283,000 5,204,000 115,000  -1,322,000 1,233,000 136,000              
          capitalized stock-based compensation in property and equipment
        		      2,180,000 1,649,000 1,787,000 1,820,000                            
          provision for doubtful accounts and contractual allowances
        		       16,289,000 17,973,000 14,169,000 16,061,000 21,425,000  14,529,000 15,227,000 14,022,000  9,755,000 4,412,000 9,768,000  6,927,000 4,340,000 9,184,000  6,898,000 5,974,000 4,709,000  2,481,000 3,760,000 2,680,000      
          accounts payable
        		        -1,668,000 62,000 -2,629,000 2,262,000 112,000 1,417,000 786,000 -5,308,000 5,643,000 -1,381,000 1,200,000 673,000 819,000 -160,000 -1,705,000 -2,835,000 5,723,000 -1,144,000 1,358,000 -333,000 332,000 -630,000 1,056,000 -950,000 667,000 -559,000 1,216,000 -690,000 236,000 
          accrued liabilities
        		        8,388,000 12,180,000 9,958,000 -11,228,000 6,401,000 9,348,000 8,153,000 -9,429,000 -3,392,000 13,323,000 4,155,000 -6,140,000 6,673,000 4,324,000 -222,000 -9,467,000 367,000 8,822,000 3,193,000 -6,380,000 7,441,000 2,838,000 3,474,000 -2,977,000 4,070,000 1,075,000 2,092,000 -1,873,000 3,743,000 
          purchase of strategic investment
        		        0 0                            
          payment of loans
        		                                     
          proceeds from term loans
        		                                     
          tax withholding upon vesting of restricted stock awards
        		                0 -1,000 -747,000 -25,105,000 -1,297,000 -3,563,000 -687,000 -4,462,000 -177,000 -1,554,000 -299,000 -3,258,000 -2,239,000 -100,000 -264,000 -1,274,000      
          payment of issuance costs for long-term debt
        		                                     
          right-of-use assets obtained in exchange for operating lease liabilities
        		        -117,000    20,000 0 0 7,666,000                      
          proceeds from term loan
        		             0 0 35,000,000                      
          payments of issuance costs for long-term debt
        		                                     
          net decrease in cash and cash equivalents
        		         -14,100,000 8,774,000 -26,028,000                      4,180,000 666,000 -36,060,000  
          cash and cash equivalents, beginning of period
        		         0 0 78,832,000                      0 0 51,643,000  
          cash and cash equivalents, end of period
        		         -14,100,000 8,774,000 52,804,000                      4,180,000 666,000 15,583,000  
          property and equipment included in accounts payable and accrued liabilities
        		         -18,000                            
          amortization of premium and accretion of discounts on investments
        		           -1,137,000                          
          purchases of short-term investments
        		           -33,757,000 -51,021,000                         
          sales of short-term investments
        		            0                         
          maturities of short-term investments
        		           46,000,000 50,000,000                         
          capitalized stock-based compensation
        		           1,648,000 1,557,000 1,524,000 1,532,000 1,250,000 1,059,000 902,000 721,000 911,000                  
          benefit from doubtful accounts and contractual allowances
        		                                     
          reimbursement of tenant improvement allowance
        		                 0                    
          issuance of common stock in connection with follow-on public offering
        		                                     
          accretion of discounts on investments
        		             -147,000             -192,000 -227,000          
          payment of long-term debt
        		             0 0 -21,389,000                      
          payments of issuance costs for long term debt
        		             0 -26,000 -51,000                      
          cash and cash equivalents beginning of period
        		             0 0 127,562,000  0 0 88,628,000  0 0 20,462,000              
          cash and cash equivalents end of period
        		             -30,031,000 6,467,000 94,786,000  28,499,000 1,497,000 137,375,000  13,606,000 25,216,000 56,514,000              
          supplemental disclosures of cash flow information
        		                                     
          non-cash investing and financing activities
        		                                     
          purchases of available-for-sale investments
        		              -45,545,000 -45,974,000 -55,508,000 -20,247,000 -16,375,000 -30,054,000 -62,621,000 -206,880,000 0 -8,009,000 -19,889,000 -101,050,000 -35,360,000 -9,616,000 -19,088,000 -31,454,000 -37,179,000 -5,437,000 -39,586,000 -34,209,000 -24,212,000 -31,822,000  
          sales of available-for-sale investments
        		              19,946,000 15,019,000     0 0 0 14,525,000              
          maturities of available-for-sale investments
        		              36,000,000 28,000,000 33,000,000 47,215,000 24,000,000 151,300,000 47,500,000 8,000,000 31,845,000 56,800,000 17,700,000 17,350,000 22,850,000 37,700,000 18,888,000 34,601,000 45,000,000 28,004,000 30,025,000 40,882,000 24,500,000 3,300,000  
          accretion of discounts on investments, net and other
        		               432,000  338,000 512,000 498,000  38,000                
          amortization of debt discount and issuance costs
        		                       4,000 4,000 2,000 5,000 26,000 92,000 -7,000 61,000 64,000 63,000 69,000 64,000 64,000 -33,000 
          accretion of discounts on investments, net of premium amortization
        		                       -171,000 -268,000             
          provision for bad debt and contractual allowance
        		                                3,476,000 1,711,000    
          cost of operating lease right-of-use assets
        		                                     
          repayments of long-term debt
        		                                     
          deferred offering costs included in accounts payable and accrued liabilities
        		                                     
          right-of-use assets obtained in exchange for new operating lease liabilities
        		                  290,000 5,757,000 0 0 0 621,000 -310,000             
          issuance of common stock in follow-on public offering, net of offering costs
        		                                     
          offering costs included in accounts payable and accrued liabilities
        		                                     
          payment of long term debt
        		                  -2,916,000 -2,917,000                  
          loss on disposal of assets
        		                            4,000         
          repayment of interest paid in kind
        		                                     
          deferred rent
        		                            52,000 -8,000 -5,000 66,000 -8,000 29,000   -1,000 
          proceeds from long-term debt, net of debt discount
        		                                     
          premiums paid on extinguishment of debt
        		                                     
          issuance of common stock in connection with follow-on public offering, net of offering costs
        		                                     
          offering costs in accounts payable and accrued liabilities
        		                                     
          proceeds from issuance of common stock
        		                      6,392,000 2,969,000 3,086,000 1,000,000 3,289,000 2,120,000  1,615,000 4,192,000 877,000      
          non-cash interest expense
        		                                398,000 393,000 384,000 375,000 382,000 
          payments of deferred offering costs
        		                                     
          issuance of common stock in public offering
        		                                     
          repayment of debt
        		                             0        
          stock offering costs included in accounts payable and accrued liabilities
        		                                     
          cash, cash equivalents and restricted cash beginning of period
        		                          0 20,023,000  0 0 8,671,000      
          cash, cash equivalents and restricted cash end of period
        		                          -12,081,000 28,235,000  -1,896,000 2,768,000 16,473,000      
          property, plant and equipment costs included in liabilities
        		                                     
          property, plant and equipment costs included in accounts payable and accrued liabilities
        		                           38,000  -132,000        
          amortization on investments
        		                                     
          change in fair value of preferred stock warrant liabilities
        		                                    1,127,000 
          proceeds from issuance of common stock upon exercise of stock options, net of repurchases
        		                                   35,000 50,000 
          proceeds from issuance of common stock upon exercise of warrants
        		                                     
          proceeds from long-term debt, net of debt discount and issuance costs
        		                                     
          proceeds of issuance of common stock upon initial public offering
        		                                     
          conversion of preferred stock to common stock
        		                                     
          conversion of preferred stock warrants to common stock warrants
        		                                     
          amortization of premiums (accretion of discounts) on investments
        		                             -283,000 -179,000 -171,000  -91,000 -70,000 -46,000  
          property, plant and equipment costs included in accounts payable
        		                               80,000  -22,000    
          change in accrued interest
        		                                     
          restricted cash
        		                                     
          proceeds from issuance of convertible preferred stock, net of issuance costs
        		                                     
          payments of issuance costs for revolving line of credit
        		                                     
          issuance of warrants to purchase preferred stock
        		                                     
          series e convertible preferred stock issuance costs included in accrued liabilities
        		                                     
          property and equipment included in accounts payable
        		                                    271,000 
          change in restricted cash
        		                                     
          net proceeds from employee stock transactions
        		                                     
          payments of deferred issuance costs
        		                                     
          proceeds from issuance of common stock related to the exercise of options and employee stock purchase program, net of repurchases
        		                                     
          change in allowance for doubtful accounts and contractual allowance
        		                                   1,772,000  
          series e preferred stock issuance costs included in accrued liabilities
        		                                     
          deferred offering costs included in accounts payables and accrued liabilities