7Baggers

Iovance Biotherapeutics, Inc
(NASDAQ:IOVA) 

IOVA stock logo

Iovance Biotherapeutics, Inc., a clinical-stage biotechnology company, focuses on developing and commercializing cancer immunotherapy products to harness the power of a patient's immune system to eradicate cancer cells. It has six ongoing phase 2 clinical studies, including C-144-01, of its lead pro...

Founded: 2007
Full Time Employees: 148
Sector: Healthcare
Industry: Biotechnology
PharmaceuticalsOncology
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Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-09-17 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-09-17 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-09-17 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 
                                                                        
      revenue
    		                                                                    
      product revenue
    		71,430,000 86,771,000 67,455,000 59,952,000 49,324,000 73,694,000 58,555,000 31,106,000 715,000 482,000 469,000 238,000                                                         
      total revenue
    		71,430,000 86,771,000 67,455,000 59,952,000 49,324,000 73,694,000 58,555,000 31,106,000 715,000 176,750 469,000 238,000                                                         
      yoy
    		44.82% 17.74% 15.20% 92.73% 6798.46% 41593.92% 12385.07% 12969.75%                                                             
      qoq
    		-17.68% 28.64% 12.52% 21.55% -33.07% 25.85% 88.24% 4250.49% 304.53% -62.31% 97.06%                                                          
      costs and expenses *
    		                                                                    
      cost of sales **
    		42,498,000 43,111,000 38,477,000                                                                  
      research and development **
    		62,487,000 71,203,000 75,174,000                                                                  
      selling, general, and administrative **
    		38,949,000 36,400,000 34,555,000                                                                  
      depreciation and amortization
    		8,539,000 9,517,000 9,007,000                                                                  
      total costs and expenses
    		152,473,000 160,231,000 162,356,000 173,726,000 170,545,000 160,270,000 147,621,000 133,020,000 118,437,000 121,738,000 118,830,000 110,324,000 110,856,000 107,036,000 100,395,000 99,734,000 91,713,000 99,465,000 86,242,000 81,426,000 75,570,000 68,534,000 58,966,000 63,627,000 70,810,000 65,110,000 51,611,000 50,165,000 39,986,000 34,943,000 35,060,000 31,378,000 26,877,000 26,071,000 22,343,000 23,581,000 20,882,000 15,922,000 18,979,000 11,727,000 7,010,000 8,454,000 7,643,000 6,440,225 5,298,059 4,868,185 2,802,500 55,141,399 2,110,169 2,259,514 11,497,530 9,409,063  1,029,260 704,913 1,722,706 1,627,636  1,646,425 3,136,133         
      income from operations
    		-81,043,000 -73,460,000 -94,901,000 -113,774,000 -121,221,000 -86,576,000 -89,066,000 -101,914,000 -117,722,000 -121,256,000 -118,361,000 -110,086,000 -110,856,000 -107,036,000 -100,395,000 -99,734,000 -91,713,000 -99,465,000 -86,242,000 -81,426,000 -75,570,000 -68,534,000 -58,966,000 -63,627,000 -70,810,000 -65,110,000 -51,611,000 -50,165,000 -39,986,000 -34,943,000 -35,060,000 -31,378,000 -26,877,000 -26,071,000 -22,343,000 -23,581,000 -20,882,000 -15,922,000 -18,979,000 -11,727,000 -7,010,000 -8,454,000 -7,643,000 -6,440,225  -4,868,185 -2,802,500 -55,141,399 -2,110,169 -2,259,514 -11,497,530 -9,409,063  -1,029,260 -704,913 -1,722,706 -1,627,636  -1,646,425 -3,136,133 -4,184,743 -5,814,141 -10,561,185 -658,250 -496,077 -167,027 -84,629 -67,680 
      yoy
    		-33.14% -15.15% 6.55% 11.64% 2.97% -28.60% -24.75% -7.42% 6.19% 13.29% 17.90% 10.38% 20.87% 7.61% 16.41% 22.48% 21.36% 45.13% 46.26% 27.97% 6.72% 5.26% 14.25% 26.84% 77.09% 86.33% 47.21% 59.87% 48.77% 34.03% 56.92% 33.06% 28.71% 63.74% 17.72% 101.08% 197.89% 88.34% 148.32% 82.09%  73.66% 172.72% -88.32%  115.45% -75.63% 486.05%  119.53% 1531.06% 446.18%   -57.19% -45.07% -61.11%  -84.41% 376.43% 743.57% 3380.96% 12379.39% 872.59%     
      qoq
    		10.32% -22.59% -16.59% -6.14% 40.02% -2.80% -12.61% -13.43% -2.91% 2.45% 7.52% -0.69% 3.57% 6.61% 0.66% 8.75% -7.79% 15.33% 5.91% 7.75% 10.27% 16.23% -7.33% -10.14% 8.75% 26.16% 2.88% 25.46% 14.43% -0.33% 11.73% 16.75% 3.09% 16.69% -5.25% 12.93% 31.15% -16.11% 61.84% 67.29% -17.08% 10.61% 18.68%   73.71% -94.92% 2513.13% -6.61% -80.35% 22.20%   46.01% -59.08% 5.84%   -47.50% -25.06% -28.02% -44.95% 1504.43% 32.69% 197.00% 97.36% 25.04%  
      operating margin %
    		-113.46% -84.66% -140.69% -189.78% -245.76% -117.48% -152.11% -327.63% -16464.62% -68603.11% -25236.89% -46254.62% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% -Infinity% -Infinity% -Infinity% -Infinity% NaN% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      other income
    		                                                                    
      interest and other income
    		1,333,000 1,740,000 1,243,000 4,104,000 3,220,000                                                                
      net loss before income taxes
    		-79,710,000 -71,720,000 -93,658,000 -109,670,000 -118,001,000 -77,001,000 -85,061,000 -98,559,000 -114,384,000 -118,138,000 -115,003,000 -107,005,000                                                         
      income tax benefit
    		665,000 -184,000 2,405,000 -1,988,000 1,838,000 -1,558,000 1,520,000 1,458,000 1,408,000 1,759,000 1,243,000 477,000                                                         
      net income
    		-79,045,000 -71,904,000 -91,253,000 -111,658,000 -116,163,000 -78,559,000 -83,541,000 -97,101,000 -112,976,000 -116,379,000 -113,760,000 -106,528,000 -107,370,000 -105,319,000 -99,618,000 -99,349,000 -91,607,000 -99,330,000 -86,122,000 -81,351,000 -75,449,000 -68,397,000 -58,571,000 -63,018,000 -69,595,000 -63,568,000 -49,487,000 -47,551,000 -36,950,000 -32,575,000 -33,830,000 -30,660,000 -26,515,000 -25,854,000 -22,149,000 -23,377,000 -20,684,000 -15,688,000 -18,758,000 -11,563,000 -6,884,000 -8,377,000 -7,635,000 -6,367,490 -5,298,059 -4,866,715 -2,798,310 -58,325,072 -2,110,169 -2,259,514 -11,496,516 -9,409,063  -3,429,255 -1,046,529 3,466,241 -673,896  -327,284 -5,772,679 -8,351,586 -5,818,478 -10,959,741 -564,296 -741,922 -713,757 -84,629 -67,680 
      yoy
    		-31.95% -8.47% 9.23% 14.99% 2.82% -32.50% -26.56% -8.85% 5.22% 10.50% 14.20% 7.23% 17.21% 6.03% 15.67% 22.12% 21.42% 45.23% 47.04% 29.09% 8.41% 7.60% 18.36% 32.53% 88.35% 95.14% 46.28% 55.09% 39.36% 26.00% 52.74% 31.15% 28.19% 64.80% 18.08% 102.17% 200.46% 87.27% 145.68% 81.59% 29.93% 72.13% 172.84% -89.08% 151.07% 115.39% -75.66% 519.88%  -34.11% 998.54% -371.45%   219.76% -160.05% -91.93%  -97.01% 922.99% 1025.67% 715.19% 12850.34% 733.77%     
      qoq
    		9.93% -21.20% -18.27% -3.88% 47.87% -5.96% -13.96% -14.05% -2.92% 2.30% 6.79% -0.78% 1.95% 5.72% 0.27% 8.45% -7.78% 15.34% 5.86% 7.82% 10.31% 16.78% -7.06% -9.45% 9.48% 28.45% 4.07% 28.69% 13.43% -3.71% 10.34% 15.63% 2.56% 16.73% -5.25% 13.02% 31.85% -16.37% 62.22% 67.97% -17.82% 9.72% 19.91% 20.19% 8.86% 73.92% -95.20% 2664.00% -6.61% -80.35% 22.19%   227.68% -130.19% -614.36%   -94.33% -30.88% 43.54% -46.91% 1842.20% -23.94% 3.95% 743.40% 25.04%  
      net income margin %
    		-110.66% -82.87% -135.28% -186.25% -235.51% -106.60% -142.67% -312.16% -15800.84% -65843.85% -24255.86% -44759.66% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% NaN% -Infinity% -Infinity% Infinity% -Infinity% NaN% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      net income per share
    		-0.19 -0.15 -0.25 -0.33 -0.36 -0.25 -0.28 -0.34 -0.42 -0.45 -0.46 -0.47 -0.5 -0.64 -0.63 -0.63 -0.58 -0.63 -0.55 -0.53 -0.51 -0.47 -0.4 -0.47                -0.23 -0.14 -0.18 -0.16 -0.14 -0.14 -0.18 -0.11  -0.09 -0.11 -1.5 -0.66  -0.01 1.28 0.05 -0.01   0.07 -0.11 -0.07 -0.15 -0.01     
      weighted-average shares of common stock outstanding, basic and diluted
    		418,511 357,345 364,037 334,511 322,868 289,877 303,269 284,817 266,220 235,131 245,817 224,481 213,694 159,259 157,817 157,274 157,113 153,406 155,508 153,751 147,370 138,301 146,492 133,162                                             
      * non-cash stock-based compensation included in cost of sales and operating expenses
    		                                                                    
      cost of sales
    		1,019 1,309 1,408 56,664,000 49,741,000 45,543,000 39,823,000 31,368,000 7,261,000 4,365,000 4,340,000 2,050,000                                                         
      research and development
    		5,117 5,672 5,011 79,363,000 76,879,000 72,224,000 68,245,000 62,084,000 79,783,000 87,470,000 87,526,000 86,347,000 82,734,000 80,573,000 72,502,000 73,406,000 68,300,000                 17,586,000 17,753,000 19,653,000 16,623,000 10,837,000 8,481,000 4,463,000 4,192,000 3,323,000 4,983,000  2,011,033 1,686,829 353,879 5,215,074 361,227 302,662 559,367 250,000  250,000 270,000 250,000 250,000  270,000 886,000         
      selling, general and administrative
    		5,133 4,836 5,481   27,628,500 39,553,000 39,568,000 31,393,000 29,903,000 26,964,000 21,927,000                                                         
      * non-cash stock-based compensation included in cost of sales and operating expenses - sum
    		11,269 11,817 11,900                                                                  
      ** excludes depreciation and amortization
    		                                                                    
      restructuring charges
    		  5,143,000                                                                  
      costs and expenses
    		                                                                    
      selling, general, and administrative
    		   37,699,000 43,925,000                                                                
      interest income
    		     2,674,500 4,005,000 3,355,000 3,338,000 3,118,000 3,358,000 3,081,000 3,486,000 1,717,000 777,000 385,000 106,000 135,000 120,000 75,000 121,000 137,000 395,000 609,000 1,215,000 1,542,000 2,124,000 2,614,000 3,036,000 2,368,000 1,230,000 718,000 362,000 217,000 194,000 204,000 198,000 234,000 221,000 164,000 126,000 77,000 8,000 72,735  1,470 4,190                      
      general and administrative
    		            28,122,000 26,463,000 27,893,000 26,328,000 23,413,000                 8,485,000 4,590,000 3,928,000 4,259,000 5,085,000 10,498,000 7,264,000 2,818,000                        79,834 167,027 84,629 67,680 
      ​
    		                                                                    
      research and development expenses
    		                 45,855,750 65,355,000 62,119,000 55,949,000 52,451,000 43,050,000 49,274,000 56,952,000 54,238,000 41,582,000 39,298,000 30,905,000 27,418,000 27,947,000 24,551,000 19,912,000                                    
      general and administrative expenses
    		                 14,953,750 20,887,000 19,307,000 19,621,000 16,083,000 15,916,000 14,353,000 13,858,000 10,872,000 10,029,000 10,867,000 9,081,000 7,525,000 7,113,000 6,827,000 6,965,000                                    
      revenues
    		                                                                    
      net loss per common share, basic and diluted
    		                        -550 -510 -400 -380 -300 -260 -360 -340 -310 -350 -350 -370 -330 -210 -1,150                              
      weighted- average common shares outstanding, basic and diluted
    		                        126,568,000                                            
      weighted-average common shares outstanding, basic and diluted
    		                          124,035,000 123,567,000 123,415,000  95,077,000 90,236,000 84,350,000 65,242,000 63,332,000 62,457,000 62,286,000 55,268,000 59,113,000 51,081,519 48,547,534 44,410,036 47,271,593 45,082,176 37,678,662     20,798,229 9,762,513     79,853,033     75,923,905 78,299,552       
      deemed dividend related to beneficial conversion feature of convertible preferred stock
    		                                      -49,454,000         -8,461,627                     
      net loss attributable to common stockholders
    		                                 -25,854,000 -22,149,000   -15,688,000 -68,212,000           -2,259,514                   
      operating expenses
    		                                         1,814,750 2,660,000  3,287,026 3,181,356 2,448,621 33,110,039 1,748,942 1,956,852    779,260  1,472,706 1,377,636    2,269,146 5,814,141 10,561,185 658,250     
      operating expenses*
    		                                           2,384,537                         
      research and development**
    		                                           4,055,688                         
      balance - january 1, 2015
    		                                            5,694                        
      fair value of vested stock options
    		                                                                    
      common stock issued upon exercise of warrants
    		                                                                    
      common stock issued upon conversion of preferred shares
    		                                            -2,000                        
      common stock sold in private placement, net of offering costs
    		                                                                    
      vesting of restricted shares issued for services
    		                                                                    
      balance - march 31, 2015
    		                                            3,694                        
      cost of lion transaction
    		                                                  1,675,000 6,700,000                 
      cost to induce exchange transaction
    		                                               -2,295,868      -2,295,868               
      total other income
    		                                             1,470 4,190 -3,183,673   1,014   -2,399,995 -341,616 5,188,947 953,739  1,319,141 -2,636,546 -4,166,843 -4,337       
      weighted-average common shares
    		                                                                    
      outstanding, basic and diluted
    		                                             877,755 26,632,908  24,137,782  1,759,377.5 14,152,052  6,241,327 818,806 19,560,238 78,293,095  78,293,095 78,136,665         
      cost of lion transaction - related party
    		                                               16,656,250                     
      impairment of intangible asset
    		                                               160,036                     
      interest expense
    		                                               -2,517,945   1,014   -104,127 -341,616 -1,595,502 -126,924  -110,810 -88,472 -119,863 -31,644       
      change in fair value of derivative liabilities
    		                                               10,001,955        243,924.5 1,595,933  1,927,839 -2,548,074 -1,645,405 3,546,042       
      amortization of discount on convertible notes
    		                                               -5,497,888           -497,888          
      financing costs
    		                                               -2,873,927                     
      net income attributable to common stockholders
    		                                               -66,786,699                     
      total other expense
    		                                                                    
      operating expenses (including 2,139,927,
    		                                                                    
      697,671, 2,360,345, 2,357,370 and 9,749,073
    		                                                                    
      in share based compensation costs)
    		                                                  918,309 2,459,063                 
      amortization of discount on notes
    		                                                       -124,472             
      operating expenses (including 87,386
    		                                                                    
      1,227,227, and 16,224,743 of non-cash
    		                                                                    
      share-based compensation costs)
    		                                                      434,913     2,250,133         
      private placement costs
    		                                                       -128,817.25 -515,269     -920,310       
      operating expenses (including 469,486,
    		                                                                    
      9,211,000, 1,696,712, 9,251,302 and 13,855,121
    		                                                                    
      in share-based compensation costs)
    		                                                          1,376,425          
      operating expenses (including 1,227,227
    		                                                                    
      40,302, and 15,835,268 of non-cash
    		                                                                    
      amortization of discount on convertible debentures and notes and other debt
    		                                                            -649,606.25 -2,598,425       
      change in fair value of derivative liability
    		                                                              -398,556 93,954 212,609 16,618   
      weighted-average shares outstanding, basic and diluted
    		                                                              74,074,238      
      balance, december 31, 2010
    		                                                              73,638,349      
      common stock sold in private placement at 1.00 per share, january 2011
    		                                                              45,000      
      common stock sold in private placement at 1.00 per share from april to june 2011
    		                                                              850,000      
      common stock issued for services, may 2011
    		                                                              130,000      
      common stock returned for cancellation
    		                                                              -3,000,000      
      fair value of vested stock options and warrants
    		                                                                    
      fair value of common stock issued to officer for services
    		                                                              6,000,000      
      fair value of common stock transferred to officer
    		                                                                    
      net loss for the period
    		                                                                    
      balance at june 30, 2011
    		                                                              77,663,349      
      weighted-average shares outstanding; basic and diluted
    		                                                               71,941,016 65,246,250    
      operating expenses:
    		                                                                    
      fair value of derivatives liability upon issuance
    		                                                                -140,837 -563,348   
      net income per share
    		-0.19 -0.15 -0.25 -0.33 -0.36 -0.25 -0.28 -0.34 -0.42 -0.45 -0.46 -0.47 -0.5 -0.64 -0.63 -0.63 -0.58 -0.63 -0.55 -0.53 -0.51 -0.47 -0.4 -0.47                -0.23 -0.14 -0.18 -0.16 -0.14 -0.14 -0.18 -0.11  -0.09 -0.11 -1.5 -0.66  -0.01 1.28 0.05 -0.01   0.07 -0.11 -0.07 -0.15 -0.01     
      basic and diluted
    		                                                                -0.003 -0.01   
      weighted average shares outstanding:
    		                                                                    
      basic and diluted
    		                                                                 72,002,038 71,860,008 113,176,668 
                                                                        
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 
                                                                   
        assets
      		                                                             
        current assets
      		                                                             
        cash and cash equivalents
      		196,508,000 163,078,000 158,134,000 132,469,000 171,668,000 115,694,000 164,186,000 228,678,000 134,188,000 114,888,000 267,720,000 230,010,000 543,484,000 231,731,000 118,366,000 108,075,000 92,360,000 78,229,000 58,590,000 82,763,000 131,954,000 67,329,000 68,310,000 160,614,000 52,540,000 13,969,000 38,889,000 76,912,000 54,093,000 82,152,000 80,738,000 246,017,000 297,082,000 145,373,000 163,380,000 114,285,000 107,099,000 106,717,000 92,895,000 101,222,000 13,642,000 10,210,000 12,556,290 111,280,443 44,909,147 17,189,671 18,440,361 17,943,877 19,672,177 129,804 15,739  510,217 910,608 268,565 722,994 1,292,469 795,943 209,263 311,799  
        trade accounts receivable
      		81,758,000 82,448,000 66,761,000 59,938,000 70,938,000 69,340,000 55,768,000 31,604,000 234,000 151,000  33,000                                                  
        short-term investments
      		116,935,000 133,902,000 142,669,000 168,714,000 188,045,000 208,087,000 233,302,000 183,864,000 222,007,000 164,979,000 93,654,000 20,884,000 82,808,000 240,114,000 241,807,000 316,383,000 389,829,000 426,181,000 517,859,000 573,605,000 461,976,000 562,108,000 645,838,000 611,265,000 193,112,000 293,112,000 322,985,000 327,241,000 385,925,000 386,371,000 179,262,000 30,082,000    14,732,000 40,098,000 59,753,000 86,387,000                       
        inventory
      		58,376,000 51,678,000 51,710,000 49,833,000 65,545,000 51,520,000 38,578,000 27,854,000 17,617,000 10,372,000 9,195,000 9,720,000                                                  
        prepaid expenses and other assets
      		12,925,000 11,583,000 9,817,000 11,546,000 15,894,000 12,377,000 6,744,000 10,183,000 11,487,000 17,458,000 12,017,000 14,231,000 11,489,000 7,271,000 9,711,000 7,135,000 7,779,000 3,546,000 6,577,000 10,272,000 11,288,000 6,663,000 9,442,000 10,775,000 10,729,000 9,412,000    6,851,000 5,863,000 3,682,000 5,644,000                             
        total current assets
      		466,502,000 442,689,000 429,091,000 422,500,000 512,649,000 457,018,000 498,578,000 482,257,000 385,533,000 307,848,000 382,586,000 274,878,000 637,781,000 479,116,000 369,884,000 431,593,000 489,968,000 507,956,000 583,026,000 666,640,000 605,218,000 636,100,000 723,590,000 782,654,000 256,381,000 316,493,000 367,307,000 410,938,000 444,753,000 475,374,000 265,863,000 279,781,000 302,726,000 149,290,000 171,375,000 135,434,000 152,593,000 169,512,000 180,556,000 192,350,000 103,977,000 110,391,000 112,714,536 111,409,326 44,975,281 17,230,812 18,519,571 18,067,968 19,845,893 138,682 24,367 34,050 524,081 3,298,108 326,065 788,286 1,300,916 801,093 214,413 316,949 8,407 
        property and equipment
      		131,394,000 131,112,000 126,650,000 122,473,000 111,584,000 109,081,000 112,520,000 110,960,000 111,789,000 114,030,000 113,142,000 112,549,000 109,923,000 105,232,000 100,746,000 101,154,000 102,757,000 100,938,000 88,034,000 80,120,000 72,750,000 59,159,000 39,112,000 18,726,000 13,607,000 8,536,000 5,856,000 4,472,000 3,504,000 2,683,000 2,640,000 2,706,000 2,247,000 2,450,000 2,595,000 2,578,000 2,796,000 2,374,000 1,769,000 1,192,000 1,676,000 1,833,000 2,025,056 2,128,260 1,531,566 170,990 15,771 14,628 27,756 29,944   28,349 18,803 16,299       
        intangible assets
      		269,104,000 279,324,000 285,208,000 296,253,000 285,356,000 282,398,000 306,639,000 295,299,000 294,303,000 229,258,000 223,610,000 235,511,000                                                  
        operating lease right-of-use assets
      		44,382,000 45,899,000 48,763,000 49,949,000 50,903,000 55,201,000 66,743,000 69,123,000 71,516,000 62,515,000 66,265,000 67,631,000 70,431,000 73,015,000 68,268,000 70,845,000 73,475,000 68,983,000 72,423,000 52,508,000 55,131,000 54,756,000 10,682,000 7,480,000 9,305,000 10,695,000 13,738,000 11,719,000 9,957,000                                 
        restricted cash
      		5,992,000 5,980,000 5,965,000 5,944,000 559,000 6,359,000 6,355,000 74,000 6,430,000 66,430,000 66,430,000 66,430,000 6,430,000 6,430,000 6,430,000 6,430,000 6,084,000 6,084,000 6,084,000 6,084,000 6,084,000 5,525,000 5,525,000 5,525,000 5,525,000 5,450,000 5,450,000 5,450,000                          2,320,000        
        long-term assets
      		8,291,000 8,166,000 9,271,000 10,318,000 426,000 369,000 280,000 327,000 259,000 270,000 282,000 294,000 202,000 189,000 596,000 856,000 1,266,000 1,784,000 1,011,000 1,150,000 1,163,000 12,918,000 3,385,000 3,182,000 3,480,000 3,481,000 3,395,000 3,345,000 3,288,000 2,764,000 2,331,000 2,264,000 2,275,000 3,633,000                            
        total assets
      		925,665,000 913,170,000 904,948,000 907,437,000 966,740,000 910,426,000 991,115,000 964,322,000 869,830,000 780,351,000 852,315,000 757,293,000 824,767,000 663,982,000 545,924,000 610,878,000 701,251,000 777,333,000 828,825,000 852,790,000 750,573,000 768,458,000 782,294,000 817,567,000 288,298,000 344,655,000 395,746,000 435,924,000 461,502,000 480,821,000 270,834,000 284,751,000 307,248,000 155,373,000 173,970,000 138,012,000 155,389,000 171,886,000 182,325,000 193,542,000 105,653,000 112,224,000 114,739,592 113,537,586 46,506,847 17,416,876 18,535,342 18,082,596 19,873,649 168,626 65,611 76,847 568,430 3,438,596 466,166 930,205 1,460,952 1,020,235 433,729 536,438 9,632 
        liabilities and stockholders’ equity
      		                                                             
        current liabilities
      		                                                             
        accounts payable
      		37,450,000 22,159,000 31,237,000 32,004,000 28,489,000 27,509,000 31,686,000 20,416,000 25,700,000 33,123,000 19,274,000 31,157,000 31,572,000 26,603,000 24,255,000 20,009,000 20,454,000 27,377,000 12,181,000 21,914,000 13,369,000 13,513,000 24,794,000 10,238,000 10,614,000 15,567,000 9,921,000 12,782,000 7,589,000 2,739,000 6,014,000 5,196,000 6,576,000 1,232,000 2,905,000 3,695,000 2,174,000 863,000 228,000 725,000 958,000 1,161,000 1,156,922 1,107,370 1,248,413 573,801 440,550 286,325 412,976 1,550,865 609,266 504,252 190,048 206,864 130,638 72,493 30,292 25,492 15,777 17,061  
        accrued expenses and other liabilities
      		88,071,000 111,156,000 87,267,000 89,081,000 84,705,000 81,936,000                                                        
        note payable - current
      		1,000,000 1,000,000 1,000,000 1,000,000 1,000,000                                                         
        operating lease liabilities
      		2,899,000 4,043,000 6,281,000 7,070,000 8,499,000 12,896,000 11,551,000 11,436,000 11,078,000 7,777,000 10,468,000 10,866,000 12,614,000 12,587,000 7,171,000 6,483,000 7,710,000 5,057,000        7,252,000 8,370,000 7,484,000 6,059,000                                 
        total current liabilities
      		129,420,000 138,358,000 125,785,000 129,155,000 122,693,000 122,341,000 118,056,000 93,639,000 83,214,000 110,306,000 90,955,000 88,643,000 87,274,000 91,485,000 79,245,000 64,192,000 77,075,000 89,200,000 64,766,000 60,534,000 55,059,000 54,871,000 64,390,000 54,905,000 39,545,000 39,084,000 34,613,000 33,836,000 22,137,000 14,398,000 16,674,000 14,182,000 14,690,000 9,892,000 8,529,000 8,860,000 5,503,000 4,968,000 3,194,000 4,606,000 1,630,000 2,855,000 1,866,196 1,910,717 1,661,760 1,258,689 1,156,472 1,109,486 2,269,932 3,509,085 16,683,973 17,335,298 13,349,348 9,129,321 1,870,111 771,114 822,867 572,222 15,777 35,198 23,120 
        non-current liabilities
      		                                                             
        operating lease liabilities – non-current
      		43,877,000 44,401,000 45,211,000 45,096,000 44,220,000 44,365,000 66,389,000 69,246,000 72,291,000 67,085,000 68,009,000 68,844,000 69,612,000 71,859,000 71,943,000                                               
        deferred tax liabilities
      		30,614,000 31,828,000 31,665,000 34,698,000 31,962,000 32,315,000 32,215,000 31,897,000 33,301,000 17,347,000 18,343,000 20,237,000                                                  
        total non-current liabilities
      		74,491,000 76,229,000 76,876,000 79,794,000 76,182,000 77,680,000 99,604,000 102,143,000 106,592,000 85,432,000 87,352,000 90,081,000 70,612,000 72,859,000 72,943,000 73,996,000 72,184,000 66,474,000 65,729,000 47,843,000 48,083,000 57,089,000 6,063,000 4,353,000 5,440,000 6,600,000 6,070,000 4,666,000 4,433,000 230,000                                
        total liabilities
      		203,911,000 214,587,000 202,661,000 208,949,000 198,875,000 200,021,000 217,660,000 195,782,000 189,806,000 195,738,000 178,307,000 178,724,000 157,886,000 164,344,000 152,188,000 138,188,000 149,259,000 155,674,000 130,495,000 108,377,000 103,142,000 111,960,000 70,453,000 59,258,000 44,985,000 45,684,000 40,683,000 38,502,000 26,570,000 14,628,000                                
        commitments and contingencies
      		                                                             
        stockholders’ equity
      		                                                             
        series a convertible preferred stock, 0.001 par value...
      		                                                             
        series b convertible preferred stock, 0.001 par value...
      		2,000 2,000 2,000 2,000 2,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 4,000 4,000 4,000 4,000 4,000 4,000 6,000 6,000 6,000 6,000 6,000 7,000 7,000 8,000 8,000 8,000 8,000                        
        common stock
      		18,000 17,000 16,000 14,000 14,000 13,000 13,000 12,000 12,000 11,000 11,000 9,000 9,000 8,000 7,000 7,000 7,000 7,000 7,000 7,000 6,000 6,000 6,000 6,000 5,000 5,000 5,000 5,000 5,000 5,000 4,000 4,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 2,000 2,000 1,964 1,870         3,250 3,291 3,236 2,945 3,068     
        accumulated other comprehensive income
      		12,650,000 16,440,000        2,526,000 -9,097,000 325,000      -601,000 -5,000 33,000 96,000 19,000 155,000 317,000 912,000  239,000 372,000 138,000        2,000 29,000 163,000 78,000 48,000 38,000 21,704                   
        additional paid-in capital
      		3,563,659,000 3,457,654,000 3,389,792,000 3,289,986,000 3,262,270,000 3,095,987,000 3,063,190,000 2,990,451,000 2,805,244,000 2,594,448,000 2,579,087,000 2,360,468,000 2,342,703,000 2,068,867,000 1,858,783,000 1,838,778,000 1,818,377,000 1,794,695,000 1,771,440,000 1,731,363,000 1,552,968,000 1,486,662,000 1,473,472,000 1,461,207,000 882,599,000 869,354,000 861,859,000 854,596,000 844,789,000 838,984,000 594,455,000 576,917,000 568,243,000 394,651,000 388,756,000 330,318,000 327,673,000 323,994,000 320,140,000 311,268,000 207,950,000 204,929,000 200,832,015 193,239,795 121,160,415 87,607,055 86,029,444 83,346,665 81,884,897 40,582,801 16,357,027 15,887,542 14,592,408 13,330,974 11,799,331 2,402,918 2,317,493 1,385,534 641,755 640,414 55,940 
        accumulated deficit
      		-2,854,575,000 -2,775,530,000 -2,703,626,000 -2,612,373,000 -2,500,715,000 -2,384,552,000 -2,305,993,000 -2,222,452,000 -2,125,351,000 -2,012,375,000 -1,895,996,000 -1,782,236,000 -1,675,708,000 -1,568,338,000 -1,463,019,000 -1,363,401,000 -1,264,052,000 -1,172,445,000 -1,073,115,000 -986,993,000 -905,642,000 -830,193,000 -761,796,000 -703,225,000 -640,207,000 -570,612,000 -507,044,000 -457,557,000 -410,006,000 -372,760,000 -340,185,000 -306,355,000 -275,695,000 -249,180,000 -223,326,000 -201,177,000 -177,800,000 -157,116,000 -141,428,000 -122,669,000 -104,222,000 -95,845,000 -88,227,444 -81,859,953 -76,561,894 -71,695,179 -68,896,868 -66,786,699 -64,527,185 -44,569,042 -33,476,539 -33,149,255 -27,376,576 -19,024,990 -13,206,512 -2,246,772 -1,682,476 -940,554 -226,797 -142,168  
        total stockholders’ equity
      		721,754,000 698,583,000 702,287,000 698,488,000 767,865,000 710,405,000 773,455,000 768,540,000 680,024,000 584,613,000 674,008,000 578,569,000 666,881,000 499,638,000 393,736,000 472,690,000 551,992,000 621,659,000 698,330,000 744,413,000 647,431,000 656,498,000 711,841,000 758,309,000 243,313,000 298,971,000 355,063,000 397,422,000 434,932,000 466,193,000 254,160,000 270,569,000 292,558,000 145,481,000 165,441,000 129,152,000 149,886,000 166,918,000 179,131,000 188,936,000  109,369,000 112,873,396            -1,403,945 159,091 638,085     
        total liabilities and stockholders’ equity
      		925,665,000 913,170,000 904,948,000 907,437,000 966,740,000 910,426,000 991,115,000 964,322,000 869,830,000 780,351,000 852,315,000 757,293,000 824,767,000 663,982,000 545,924,000 610,878,000 701,251,000 777,333,000 828,825,000 852,790,000 750,573,000 768,458,000 782,294,000 817,567,000 288,298,000 344,655,000 395,746,000 435,924,000 461,502,000 480,821,000 270,834,000 284,751,000 307,248,000 155,373,000 173,970,000 138,012,000 155,389,000 171,886,000 182,325,000 193,542,000  112,224,000 114,739,592            466,166 930,205 1,460,952     
        long-term note payable
      		     1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000                                         
        accumulated other comprehensive loss
      		  16,103,000 20,859,000 6,294,000 -1,046,000 16,242,000 526,000 116,000    -126,000 -902,000 -2,038,000 -2,697,000 -2,343,000         220,000    -42,000 -120,000 -3,000                              
        accrued expenses
      		      74,819,000 61,787,000 46,436,000 69,406,000 61,213,000 46,620,000 43,088,000 52,295,000 47,819,000 37,700,000 48,911,000 56,766,000 45,969,000 34,192,000 35,774,000 35,074,000 32,400,000 38,794,000 22,500,000 16,265,000 16,322,000 13,570,000 8,489,000 11,659,000 10,660,000 8,986,000 8,114,000 8,660,000 5,624,000 5,165,000 3,329,000 4,105,000 2,966,000 3,881,000 586,000 1,608,000 623,774 717,847 327,847 476,566 715,922 823,161 1,856,956 1,958,220 502,347 279,480 221,507         
        long-term investments
      		                27,701,000 91,588,000 78,247,000 46,288,000 10,227,000                                         
        operating lease liabilities – noncurrent
      		               72,996,000 71,184,000 65,474,000 64,729,000 46,843,000 47,083,000 45,375,000 3,711,000 2,001,000 3,088,000                                     
        other liabilities
      		                     11,714,000 2,352,000 2,352,000 2,352,000 2,352,000 53,000 53,000 53,000                                 
        operating lease liabilities - current
      		                  6,616,000 4,428,000 5,916,000 6,284,000 7,196,000 5,873,000 6,431,000                                     
        prepaid expenses and other current assets
      		                          5,433,000 6,785,000 4,735,000     3,917,000 7,995,000 6,417,000 5,396,000 3,042,000 1,274,000 782,000 277,000    66,134 41,141  114,091              
        2
      		                                                             
        deferred rent
      		                             230,000                                
        revenues
      		                                                             
        costs and expenses
      		                                                             
        research and development
      		                                  17,753,000               250,000 270,000 886,000          
        general and administrative
      		                                  4,590,000                           
        total costs and expenses
      		                                  22,343,000               9,409,063 1,646,425 3,136,133          
        income from operations
      		                                  -22,343,000               -9,409,063 -1,646,425 -3,136,133          
        other income
      		                                                             
        interest income
      		                                  194,000                           
        net income
      		                                  -22,149,000               -9,409,063 -327,284 -5,772,679          
        deemed dividend related to beneficial conversion feature of convertible preferred stock
      		                                                             
        net income attributable to common stockholders
      		                                  -22,149,000                           
        net income per common share, basic and diluted
      		                                  -350                           
        weighted-average common shares outstanding, basic and diluted
      		                                  63,332,000                           
        shares authorized, 62,350,149 and 62,248,074 shares issued and outstanding as of march 31, 2017 and december 31, 2016, respectively
      		                                                             
        shares authorized, 62,248,074 and 48,547,720 shares issued and outstanding as of december 31, 2016 and 2015, respectively
      		                                                             
        series a preferred stock, 0.001 par value...
      		                                                             
        series b preferred stock, 0.001 par value...
      		                                      8,000 11,000                      
        common stock to be issued, 303,125 shares
      		                                      245,000 245,000 245,000  245,153 245,153 245,153 245,153 245,153 245,153 245,153 245,153            
        money market funds
      		                                       19,744,000 19,945,000 20,562,000 7,476,855                   
        short-term investments available for sale
      		                                       70,602,000 70,113,000 79,374,000 92,302,982                   
        liabilities and stockholders' equity
      		                                                             
        accrued payable to officers and former directors
      		                                        86,000 86,000 85,500 85,500 85,500 208,322                
        stockholders' equity
      		                                                             
        preferred stock, 0.001 par value...
      		                                          4 4                  
        total stockholders' equity
      		                                        104,023,000   111,626,869 44,845,087 16,158,187 17,378,870 16,806,053 17,603,717    -12,780,918 -5,690,725    448,013 417,952 501,240  
        total liabilities and stockholders' equity
      		                                        105,653,000   113,537,586 46,506,847 17,416,876 18,535,342 18,082,596 19,873,649    568,430 3,438,596    1,020,235 433,729 536,438  
        prepaid and other current assets
      		                                         245,000                    
        common stock to be issued, 245,153 shares
      		                                         245,000                    
        prepaid expenses and deposits
      		                                          378,409 128,883                  
        5,694 shares and 17,000 shares issued and outstanding, respectively
      		                                            6 6                
        33,750,188 and 20,023,958 shares issued and outstanding, respectively
      		                                            1,407                 
        deposits
      		                                             15,074 9,744 10,000 15,000 5,000            
        27,639,688 and 20,023,958 shares issued and outstanding, respectively
      		                                             1,152                
        prepaid expenses
      		                                              69,466  158,716 3,878   4,473   7,792 3,447 5,000 5,000 5,000  
        5,800 shares and 17,000 shares issued and outstanding, respectively
      		                                              6               
        27,226,350 and 20,023,958 shares issued and outstanding, respectively
      		                                              1,135               
        the accompanying notes are an integral part of these financial statements.
      		                                                             
        accrued compensation payable in shares of stock
      		                                               167,057              
        13,300 shares and 17,000 shares issued and outstanding, respectively
      		                                               13              
        22,092,958 and 20,023,958 shares issued and outstanding, respectively
      		                                               921              
        7% senior secured convertible promissory notes
      		                                                             
        12% secured promissory note
      		                                                             
        september 2012 secured promissory note
      		                                                             
        accrued interest and penalty
      		                                                             
        17,000 shares and no shares issued and outstanding, respectively
      		                                                17             
        20,023,958 and 818,806 shares issued and outstanding, respectively
      		                                                835             
        liabilities and stockholders' deficiency
      		                                                             
        stockholders' deficiency
      		                                                             
        no shares issued and outstanding
      		                                                             
        15,072,911 and 818,806 shares issued and outstanding, respectively
      		                                                 629            
        common stock subscribed for, 400,000 shares
      		                                                 400,000            
        total stockholders' deficiency
      		                                                 -3,340,459 -16,618,362 -17,258,451          
        total liabilities and stockholders' deficiency
      		                                                 168,626 65,611 76,847          
        lion biotechnologies, inc.
      		                                                             
        condensed statements of operations
      		                                                             
        operating expenses (including 2,139,927,
      		                                                             
        697,671, 2,360,345, 2,357,370 and 9,749,073
      		                                                             
        in share based compensation costs)
      		                                                 2,459,063            
        cost of lion transaction
      		                                                 6,700,000            
        impairment of intangible asset
      		                                                             
        interest expense
      		                                                  -110,810 -88,472          
        change in fair value of derivative liabilities
      		                                                  1,927,839 -2,548,074          
        amortization of discount on notes
      		                                                             
        cost to induce exchange transaction
      		                                                             
        financing costs
      		                                                             
        total other income
      		                                                  1,319,141 -2,636,546          
        net income per share
      		                                                 -0.66  0.07          
        weighted-average common shares
      		                                                             
        outstanding, basic and diluted
      		                                                 14,152,052 78,293,095 78,136,665          
        deposits and prepaid expenses
      		                                                  8,628 34,050          
        depreciation of 5,809 and 2,704
      		                                                  25,244           
        rent deposit
      		                                                  16,000 16,000 16,000 16,000        
        accrued expenses - national institute of health
      		                                                  616,000 866,000          
        12% secured promissory notes
      		                                                  1,216,250           
        7% convertible promissory notes
      		                                                  5,000,000 5,000,000          
        derivative liabilities
      		                                                  8,740,110 10,667,947 7,937,793 6,292,388        
        78,293,095 and 77,993,591 shares issued and outstanding, respectively
      		                                                  3,262 3,262          
        common shares to be issued with 12% secured promissory notes
      		                                                  497,888           
        operating expenses (including 469,486,
      		                                                             
        9,211,000, 1,696,712, 9,251,302 and 13,855,121
      		                                                             
        in share-based compensation costs)
      		                                                  1,376,425           
        amortization of discount on convertible notes
      		                                                  -497,888           
        private placement costs
      		                                                             
        depreciation of 4,257 and 2,704
      		                                                   26,797          
        intellectual property licenses, net of accumulated amortization of
      		                                                             
        217,408 and 217,408
      		                                                             
        bank overdraft
      		                                                   17,619          
        operating expenses (including 1,227,227
      		                                                             
        40,302, and 15,835,268 of non-cash
      		                                                             
        share-based compensation costs)
      		                                                   2,250,133          
        deposit
      		                                                    9,391 17,500 7,500 7,500 5,000 150 150 150 150 
        intellectual property licenses, net of accumulated amortization of 217,408 and 57,372
      		                                                             
        unsecured convertible promissory notes
      		                                                    5,000,000         
        advance to related party
      		                                                     50,000        
        intellectual property licenses, net of accumulated amortization of 111,723 and 57,372
      		                                                     105,685        
        accrued interest
      		                                                     31,644        
        unsecured convertible promissory notes, net of discount
      		                                                     2,598,425        
        advances to related party
      		                                                      50,000 50,000      
        intellectual property licenses, net of accumulated amortization of 93,606 and 57,372
      		                                                      123,802       
        derivative liability
      		                                                      1,739,473 698,621 792,575 546,730    
        intellectual property licenses, net of accumulated amortization of 75,489 and 57,372
      		                                                       141,919      
        website, net of accumulated amortization of 3,667 and 2,442
      		                                                             
        intellectual property licenses, net of accumulated amortization of 57,372
      		                                                        160,036     
        due to director
      		                                                           18,137 23,120 
        website, net of accumulated depreciation of 347 and 2,442
      		                                                         1,734    
        intellectual property licenses
      		                                                         217,408 217,408 217,408  
        common stock; 0.000041666 par value; 1,800,000,000 shares authorized; 72,793,349 and 121,440,000 shares issued and outstanding, respectively
      		                                                         3,033    
        website, net of accumulated depreciation of 173
      		                                                          1,908   
        common stock; 0.000041666 par value; 1,800,000,000 shares authorized; 71,860,008 and 121,440,000 shares issued and outstanding, respectively
      		                                                          2,994 2,994  
        website, net of accumulated depreciation
      		                                                           2,081  
        cash
      		                                                            8,257 
        website, net of accumulated amortization
      		                                                            1,225 
        liabilities and stockholders’ deficit
      		                                                             
        accounts payable and accrued liabilities
      		                                                             
        stockholders’ deficit
      		                                                             
        issued and outstanding: 121,440,000 shares
      		                                                            5,060 
        deficit accumulated during the development stage
      		                                                            -74,488 
        total stockholders’ deficit
      		                                                            -13,488 
        total liabilities and stockholders' deficit
      		                                                            9,632 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-17 2014-06-30 2014-03-31 2013-12-31 2013-09-17 2013-06-30 2013-03-31 2012-12-31 2012-09-17 2012-06-30 2012-03-31 2011-12-31 2011-09-17 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 
                                                                         
          cash flows from operating activities
        		                                                                 
          net loss
        		-79,045,000 -71,904,000 -91,253,000 -111,658,000 -116,163,000 -78,559,000 -83,541,000 -97,101,000 -112,976,000 -116,379,000 -113,760,000 -106,528,000 -107,370,000 -105,319,000 -99,618,000 -99,349,000 -91,607,000 -99,330,000 -86,122,000 -81,351,000 -75,449,000 -68,397,000 -58,571,000 -63,018,000 -69,595,000 -63,568,000 -49,487,000 -47,551,000 -36,950,000 -32,575,000 -33,830,000 -30,660,000 -26,515,000 -25,854,000 -22,149,000 -23,377,000 -20,684,000 -15,688,000 -18,759,000 -11,563,000 -6,884,000 -8,377,000 -7,617,450 -6,367,491 -5,298,059 -4,866,715  -2,110,169 -2,259,514 -11,496,516  -3,429,255 -1,046,529 3,466,241  -327,284 -5,772,679 -8,351,586     -713,757   
          adjustments to reconcile net loss to net cash from operating activities:
        		                                                                 
          stock-based compensation expense
        		11,269,000 11,817,000 11,900,000 14,943,000 22,915,000 30,977,000 31,006,000 30,466,000 17,178,000 14,399,000 15,821,000 16,740,000 15,665,000 19,509,000 19,780,000 22,468,000 22,265,000 19,104,000 19,306,000 14,414,000 16,941,000 10,232,000 10,706,000 10,537,000 9,412,000 5,407,000 6,598,000 6,426,000 5,846,000 5,185,000 5,516,000 5,222,000 4,104,000 2,760,000 2,619,000 3,293,000 3,296,000 3,123,000                            
          unrealized foreign exchange loss
        		434,000 -373,000 232,000                                                               
          amortization of intangible assets
        		5,716,000 6,204,000 5,769,000 5,698,000 5,406,000 5,546,000 5,537,000 5,486,000 4,633,000 3,910,000 4,006,000                                                       
          amortization of right of use asset
        		1,876,000 2,716,000 2,922,000 2,877,000 2,870,000 3,166,000 2,582,000 2,393,000 2,296,000    2,933,000 2,893,000 2,748,000 3,003,000 3,181,000                                                 
          depreciation and amortization of property and equipment
        		2,823,000 3,724,000 2,986,000 3,363,000 2,789,000 2,975,000 3,029,000 2,985,000 2,978,000 2,949,000 2,924,000                                                       
          deferred tax benefit
        		-665,000    -1,838,000 1,559,000 -1,521,000 -1,458,000 -1,408,000 -1,759,000 -1,243,000                                                       
          excess and obsolescence reserve
        		-506,000 3,702,000 1,391,000                                                               
          accretion of discounts and premiums on investments
        		-1,120,000 -1,342,000 -1,711,000 -2,003,000 -2,146,000 -2,772,000 -2,655,000 -2,499,000 -2,335,000 -1,727,000 -1,023,000 123,000 -978,000                                                     
          loss on asset disposals
        		28,000 0 0 0 44,000                                                             
          changes in assets and liabilities:
        		                                                                 
          prepaid expenses, other assets and long-term assets
        		-1,466,000 -661,000 2,776,000 -6,887,000 -3,251,000 -5,318,000 -2,472,000   -5,148,000 2,151,000 -2,834,000 -4,231,000 2,846,000 -2,315,000 1,054,000 -3,715,000                                                 
          trade accounts receivable
        		690,000 -15,687,000 -6,823,000 11,000,000 -1,598,000 -13,572,000 -24,164,000 -31,370,000 -83,000                                                         
          inventory
        		-4,931,000 -4,001,000 -3,182,000 6,942,000 -13,970,000 -13,450,000 -10,873,000 -8,859,000 -6,735,000 -923,000                                                        
          operating lease liabilities
        		-2,027,000 -2,900,000 -2,410,000 -2,477,000 -3,113,000 -3,651,000 -2,945,000 -2,689,000 -2,789,000 -2,720,000 -2,813,000      690,000 -25,568,000 20,074,000 -1,728,000 1,340,000 -5,895,000 -1,840,000 -1,278,000 -2,461,000 -1,834,000 -1,663,000 -1,709,000 -942,000                                     
          accounts payable
        		15,888,000 -5,213,000 -4,393,000 893,000 2,052,000 -6,072,000 14,436,000 -10,390,000 -5,815,000 11,423,000 -9,766,000 146,000 3,025,000 1,556,000 4,262,000 2,169,000 -2,104,000 7,716,000 -5,690,000 4,965,000 -15,000 -12,132,000 16,264,000 672,000 -7,768,000 6,081,000 -3,326,000 5,369,000 4,582,000 -3,275,000 1,096,000 -1,553,000 5,239,000 -1,779,000 -839,000 1,521,000 1,466,000                             
          accrued expenses and other liabilities
        		-21,038,000 21,169,000 5,499,000 -281,000 2,250,000 4,084,000 12,701,000   9,405,000 15,931,000 3,492,000 -9,054,000 909,000 9,443,000 -9,891,000 -5,164,000 22,730,000 8,477,000 3,878,000 -14,401,000 15,854,000 -10,558,000 14,449,000 4,364,000 2,242,000 2,752,000 5,080,000 -3,346,000                                     
          net cash from operating activities
        		-72,074,000 -52,565,000 -78,702,000 -67,447,000 -103,694,000 -73,296,000 -58,973,000 -98,429,000 -122,279,000 -83,970,000 -84,083,000 -93,952,000 -99,815,000 -77,671,000 -63,649,000 -77,635,000 -73,802,000 -53,849,000 -57,693,000 -54,008,000 -62,391,000 -62,692,000 -40,515,000 -36,635,000 -65,292,000 -53,822,000 -42,182,000 -33,795,000 -29,090,000 -31,549,000 -27,928,000 -23,923,000 -17,849,000 -20,964,000 -21,446,000 -17,496,000 -18,803,000 -12,159,000 -12,209,000 -3,748,000 -4,552,000 -6,579,000 -3,843,421 -4,499,930 -3,458,649 -3,314,930 -2,267,363 -1,322,191 -2,267,363 -2,253,190 -300,000 -681,929 -300,000 0 -760,217 -1,200,511 -760,217 -2,709,654 -1,649,502 -1,265,568 -564,475 -369,592 -113,320   
          capital expenditures
        		-721,000 -10,653,000 -14,293,000 -669,000 280,000 -1,416,000 -17,000 -442,000 -3,488,000 -3,219,000 -3,638,000 -13,484,000 2,113,000 1,337,000 -728,000 -8,509,000 -6,540,000 -7,568,000 -8,942,000 -7,736,000 -13,963,000 -20,368,000 -20,693,000 -4,975,000 -5,323,000 -2,747,000 -1,699,000 -1,257,000 -1,092,000 -295,000 -463,000 -418,000 -34,000 58,000 -263,000 -25,000 -953,000 -740,000 -725,000 -54,000 -2,000 0 -72,867 -136,990 -782,143 0 -3,437 0 -3,437 0 0 0 0 0 0 0 0 0 0 0 0 0 0   
          free cash flows
        		-72,795,000 -63,218,000 -92,995,000 -68,116,000 -103,414,000 -74,712,000 -58,990,000 -98,871,000 -125,767,000 -87,189,000 -87,721,000 -107,436,000 -97,702,000 -76,334,000 -64,377,000 -86,144,000 -80,342,000 -61,417,000 -66,635,000 -61,744,000 -76,354,000 -83,060,000 -61,208,000 -41,610,000 -70,615,000 -56,569,000 -43,881,000 -35,052,000 -30,182,000 -31,844,000 -28,391,000 -24,341,000 -17,883,000 -20,906,000 -21,709,000 -17,521,000 -19,756,000 -12,899,000 -12,934,000 -3,802,000 -4,554,000 -6,579,000 -3,916,288 -4,636,920 -4,240,792 -3,314,930 -2,270,800 -1,322,191 -2,270,800 -2,253,190 -300,000 -681,929 -300,000 0 -760,217 -1,200,511 -760,217 -2,709,654 -1,649,502 -1,265,568 -564,475 -369,592 -113,320   
          cash flows from investing activities
        		                                                                 
          maturities of investments
        		74,000,000 70,000,000 120,000,000 90,000,000 120,000,000 116,000,000 110,000,000 115,000,000 87,000,000 38,000,000 20,950,000 62,250,000 164,383,000 99,110,000 139,450,000 140,628,000 143,508,000 218,460,000 224,303,000 161,865,000 158,286,000                                             
          purchase of investments
        		-55,998,000 -59,905,000 -92,144,000 -68,697,000 -97,922,000 -88,155,000 -156,513,000 -74,339,000 -141,762,000 -107,569,000 -93,010,000 0 -5,323,000 -95,627,000 -64,348,000 -40,289,000 -45,552,000 -141,554,000 -201,870,000 -311,414,000 -70,370,000                                             
          purchase of property and equipment
        		-6,608,000 -9,320,000 -10,844,000 -7,461,000 -6,211,000 -4,168,000 -2,288,000 -442,000 -4,171,000 -3,529,000 -3,577,000 -9,520,000 -5,664,000 -3,022,000 -1,387,000 -4,576,000 -11,440,000 -7,568,000 -9,685,000 -9,616,000 -10,705,000 -23,335,000 -17,844,000 -4,975,000 -637,000 -3,426,000 -1,234,000 -1,433,000 -824,000 -295,000 -463,000 -418,000 -22,000 58,000 -263,000 -25,000 -798,000 -740,000 -725,000 -54,000 -2,000                         
          net cash from investing activities
        		11,394,000    15,867,000 23,677,000 -48,801,000 40,219,000 -111,506,000 -72,845,000 -79,014,000 -156,779,000 153,396,000 461,000 73,715,000 95,763,000 86,516,000 69,338,000   77,211,000 58,753,000 -52,955,000 -423,756,000 100,105,000 26,814,000 3,495,000 58,683,000 1,033,000 -206,382,000 -149,373,000 -30,502,000 -22,000 58,000 14,487,000 25,330,000 18,802,000 25,765,000 -16,557,000 -167,000 -147,000     -1,426,016 -3,437 -2,305 -3,437 -1        -60,737 -3,455    0   
          cash flows from financing activities
        		                                                                 
          tax payments related to shares withheld for vested restricted stock units
        		-4,179,000 -445,000 -466,000 -504,000 -5,644,000 -880,000 -6,277,000 -1,000,000 -4,701,000 -186,000 -379,000 -301,000 -1,929,000 0 0                                                   
          proceeds from the issuance of common stock upon exercise of options
        		 0 0 0 15,000 1,799,000 713,000 390,000 364,000 8,000 0   0 225,000 0 1,417,000    6,479,000 2,959,000 1,516,000 1,237,000 3,951,000 2,207,000 762,000 3,405,000 69,000 1,593,000 1,538,000 1,198,000 5,630,000 3,062,000 1,908,000 415,000 231,000 148,000    189,000                        
          proceeds from the issuance of common stock
        		98,514,000 55,778,000 88,520,000 13,065,000 148,944,000 0 47,518,000 151,873,000 197,913,000 1,000 203,179,000 0 260,101,000     0 1,000 160,270,000 42,885,000 0 -350,000        0 -93,000 162,186,000         -1,000 162 0 68,307,838     5,886,803    0 250,000 0 250,000 0     700,000 0 365,000 
          net cash from financing activities
        		94,335,000 56,172,000 88,056,000 13,230,000 143,315,000 2,309,000 41,954,000 152,825,000 193,576,000 962,000 202,800,000 1,025,000 258,172,000 190,575,000 225,000 -2,067,000 1,417,000   163,982,000 50,364,000 2,958,000 1,166,000 568,465,000 3,833,000 2,088,000 664,000 3,381,000 -2,000 239,345,000 12,022,000 3,360,000 169,580,000 2,899,000 56,054,000 -648,000 383,000 216,000 494,000   275,000 1,709,012 5,670,900 70,612,088 32,460,422 542,500 1,820,980 542,500 21,795,563 300,000 1,251,510 300,000 0 250,000 1,216,250 250,000 2,370,000 2,295,000   863,137 700,000 -18,137 360,017 
          effect of foreign exchange rate changes
        		-213,000 577,000 -680,000 739,000 508,000 -1,178,000 1,253,000 -125,000 -491,000                                                         
          net increase in cash, cash equivalents and restricted cash
        		33,442,000 4,959,000 25,686,000 -39,636,000 55,996,000 -48,488,000 -64,567,000 94,490,000 -40,700,000 -152,832,000 37,710,000 -253,474,000 311,753,000 113,365,000 10,291,000 16,061,000 14,131,000        38,646,000                                         
          cash, cash equivalents and restricted cash beginning of period
        		169,058,000 0 0 0 122,053,000 0 0 0 181,318,000 0 0 0 238,161,000 0 0 0 84,313,000                                                 
          cash, cash equivalents and restricted cash end of period
        		202,500,000 4,959,000 25,686,000 -39,636,000 178,049,000 -48,488,000 -64,567,000 94,490,000 140,618,000 -152,832,000 37,710,000 -253,474,000 549,914,000 113,365,000 10,291,000 16,061,000 98,444,000                                                 
          supplemental disclosure of non-cash investing and financing activities:
        		                                                                 
          net unrealized loss on investments
        		85,000 14,000 -100,000 30,000 110,000                                                             
          acquisition of property and equipment included in accounts payable and accrued expenses
        		5,887,000 -1,333,000 -3,449,000 6,792,000 6,491,000 2,752,000 2,271,000   310,000 -61,000 -3,964,000 7,777,000 4,359,000 659,000 -3,933,000 4,900,000                                                 
          conversion of convertible preferred stock to common stock
        		 0 0 0 1,000             2,000 0 0 -1,000     0    0 0                                   
          increase in lease liabilities due to obtaining/(reduction in) right-of-use assets from lease modifications
        		359,000                                                                 
          deferred tax expense
        		 184,000 -2,405,000                                                               
          gain on derecognition of lease assets and liabilities
        		                                                                 
          cash paid for acquisition, including contingent consideration, net of cash acquired
        		     0                                                            
          proceeds from the issuance of common stock under employee stock purchase plan
        		 839,000 2,000   1,390,000 0   1,139,000 0   1,073,000                                                    
          fair value of net assets acquired
        		         0 0                                                       
          intangible asset and deferred tax liability arising from contingent consideration
        		     0 -6,000,000 6,000,000 17,495,000                                                         
          lease liabilities arising from obtaining right-of-use asset from new leases
        		         0 0   0 0   0                                                
          net cash from (used) in investing activities
        		  17,012,000                                                               
          increase in lease liabilities due to obtaining/(reduction) in right-of-use assets from lease modifications
        		  1,735,000 1,925,000 -1,429,000                                                             
          unrealized foreign exchange gains
        		    59,000 4,000 -93,000 10,000 -96,000                                                         
          accrued offering costs in accounts payable and accrued expenses
        		        552,000                                                         
          impairment of long-lived assets
        		                                                                 
          vesting of restricted shares issued for services
        		                                          465,130 637,425 450,445                     
          net unrealized gain on investments
        		     -142,000 269,000 20,000 -69,000 28,000 18,000 118,000 776,000                                                     
          lease liabilities arising from obtaining right-of-use asset from lease modifications
        		     -19,333,000 203,000 0 11,297,000 -896,000 1,580,000 0 349,000 7,640,000 171,000 -180,000 7,673,000 0                                                
          accrued capitalized acquisition costs
        		          -3,377,000                                                       
          cash paid for acquisition, net of cash acquired
        		         253,000 -3,377,000                                                       
          accrued expenses
        		        -23,015,000                     1,229,000 1,674,000 872,000 -546,000 3,222,000 273,000 1,836,000 -776,000                             
          contingent consideration paid for acquisition
        		        -52,573,000                                                         
          purchase of property and equipment included in accounts payable and accrued expenses
        		        683,000                                                         
          unrealized exchange gains
        		         -106,000 357,000                                                       
          loss on write-off of fixed assets
        		             83,000 0 0 314,000                                                 
          proceeds from the issuance of debt
        		                 0 0 0 1,000,000                                             
          effect of exchange rate changes
        		         3,021,000 -1,993,000                                                       
          amortization of right-of-use assets
        		          2,945,000                                                       
          inventories
        		                                                                 
          depreciation and amortization
        		            2,764,000 2,814,000 2,454,000 2,245,000 1,797,000 1,345,000 1,028,000 366,000 372,000 321,000 307,000 260,000 252,000 294,000 315,000 289,000 271,000 252,000 251,000 225,000 228,000 242,000 246,000 243,000 221,000 290,000 148,000 271,000 269,000   240,194 185,449 65,441 16,565 1,163 16,565 2,188 1,956 1,150 1,956 1,554 1,552 1,553 1,552 -53,160 19,068       
          operating lease liabilities, net of tenant improvement allowance received
        		            -2,569,000 -2,308,000 -536,000                                                   
          accretion (amortization) of discounts and premiums on investments
        		              133,000 454,000 541,000 836,000 1,315,000 1,796,000 2,066,000 1,506,000       -1,232,000                                     
          net unrealized (loss) on investments
        		                                                                 
          proceeds from the issuance of common stock upon purchase of employee stock purchase plan
        		                                                                 
          net unrealized gain on short-term investments
        		                -1,742,000   -63,000 77,000    692,000                                         
          gain on settlement of dispute
        		                         0 0 -1,000 -335,000                                     
          loss on disposal of assets
        		                             0 0 0 9,000                                 
          cash, cash equivalents and restricted cash beginning of year
        		                                                                 
          cash, cash equivalents and restricted cash end of year
        		                                                                 
          net unrealized loss on short-term investments
        		                 -596,000                                                
          acquisition of property and equipment included in accounts payable and accrued expense
        		                                                                 
          vesting of restricted stock units
        		                                                                 
          non-cash lease expense
        		                  5,223,000                                               
          prepaid expenses, other assets, and long-term assets
        		                  3,834,000 1,029,000 7,130,000 -6,754,000 1,130,000 252,000 -1,316,000 -4,063,000 1,300,000 -2,107,000 1,592,000                                     
          right-of-use assets
        		                  -25,138,000 2,501,000 -2,660,000                                             
          proceeds from the issuance of common stock upon exercise of options and employee stock purchase plan
        		                  20,771,000                                               
          net cash provided in financing activities
        		                                                                 
          net increase in cash, cash equivalents, and restricted cash
        		                  -24,173,000 -49,191,000 65,184,000 -981,000 -92,304,000                                           
          cash, cash equivalents, and restricted cash, beginning of period
        		                  0 0 72,854,000    19,419,000                                         
          cash, cash equivalents, and restricted cash, end of period
        		                  -24,173,000 -49,191,000 138,038,000    58,065,000                                         
          supplemental disclosure of non-cash operating, investing and financing activities:
        		                                                                 
          acquisitions of property and equipment included in accounts payable and accrued expense
        		                  743,000 1,880,000 -3,258,000 2,967,000 -2,849,000                                           
          net cash used by investing activities
        		                                                                 
          accrued offering costs in accrued expenses
        		                                                                 
          noncash lease expense
        		                    2,285,000 2,573,000 1,671,000 1,458,000 1,870,000 1,989,000 1,934,000 1,607,000 1,424,000                                     
          maturities of short-term investments
        		                     318,108,000 141,815,000 103,013,000 113,665,000 94,021,000 157,478,000 172,060,000 91,042,000              11,900,000                       
          purchase of short-term investments
        		                     -236,020,000 -176,926,000 -521,794,000 -12,923,000 -63,781,000 -152,749,000 -111,944,000 -89,185,000 -247,087,000 -148,910,000            1,045,278                       
          proceeds from the issuance of common stock upon exercise of warrants
        		                             1,070,000 10,543,000 2,315,000 1,826,000 274,000 138,000 94,000 156,000 356,000 258,000   87,000 1,642,850   220,000                    
          cash, cash equivalents, and restricted cash beginning of year
        		                                                                 
          cash, cash equivalents, and restricted cash end of year
        		                                                                 
          tax payments related to shares withheld for vested restricted stock awards
        		                      0 -165,000 -118,000  -98,000 -24,000 -71,000 -42,000 -59,000 -60,000 -62,000                                 
          cash, cash equivalents, and restricted cash beginning of period
        		                      0    0                                       
          cash, cash equivalents, and restricted cash end of period
        		                      -92,304,000    -38,023,000                                       
          unrealized gain on short-term investments
        		                      -162,000    -133,000 234,000 180,000     0 0 -2,000 -27,000 -134,000 85,000 10,000 20,000 10,000                        
          amortization of premiums on investments
        		                       33,000 -50,000                                         
          acquisitions of property and equipment included in accounts payable and accrued expenses
        		                        -4,686,000                                         
          proceeds from the issuance of preferred stock and common stock
        		                                 -388,000    0                            
          supplemental disclosure of cash flow information:
        		                                                                 
          cash paid for income taxes
        		                                                                 
          interest paid
        		                                                                 
          supplemental disclosure of noncash investing and financing activities:
        		                                                                 
          acquisitions of property and equipment included in accounts payable
        		                         679,000 -465,000 176,000 -268,000                                     
          accretion of discounts on investments
        		                          -605,000                                       
          net decrease in cash, cash equivalents, and restricted cash
        		                                                                 
          net increase in cash and cash equivalents
        		                            -28,059,000 1,414,000 -165,279,000 -51,065,000 151,709,000 -18,007,000 49,095,000 7,186,000 382,000 13,822,000 -28,272,000 92,279,000 -4,699,000    66,371,296 27,719,476 -1,728,300 496,484 -1,728,300         -400,391 642,043 -454,429 -569,475 496,526 586,680 -102,536 303,542 
          cash and cash equivalents, beginning of period
        		                            82,152,000 0 0 0 145,373,000 0 0 0 106,717,000 0 19,945,000 0 13,642,000 -1,000 853 0 44,909,147 0 19,672,177 0 19,672,177          0 0 1,292,469 0 0 0 8,257 
          cash and cash equivalents, end of period
        		                            54,093,000 1,414,000 -165,279,000 -51,065,000 297,082,000 -18,007,000 49,095,000 7,186,000 107,099,000 13,822,000 -8,327,000 92,279,000 8,943,000 3,432,000 -2,346,290 -98,724,153 111,280,443 27,719,476 17,943,877 496,484 17,943,877 19,542,373         642,043 -454,429 722,994 496,526 586,680 -102,536 311,799 
          offering costs under accounts payable and accrued expenses
        		                                                                 
          prepaid expenses and other assets
        		                             -1,421,000 -2,248,000 1,972,000 -368,000                                 
          accretion and amortization of discounts and premiums on investments
        		                              -387,000                                   
          unrealized loss on short-term investments
        		                              -117,000                                   
          amortization of discount on investments
        		                                                                 
          maturities of short- term investments
        		                                 0 14,750,000 25,355,000 19,600,000 26,505,000 26,278,000 28,726,000 39,155,000                         
          acquisitions of property and equipment under accounts payable
        		                                -12,000  0 0 -155,000                             
          offering costs included in accounts payable
        		                                -93,000                                 
          amortization of discount (premium) on investments
        		                                 0                                
          other assets
        		                                                         0        
          purchase of short- term investments
        		                                     0 -41,909,000 -39,067,000 -29,273,000                         
          tax payments related to shares withheld for vested restricted stock
        		                                                                 
          supplemental disclosures of cash flow information:
        		                                                                 
          deemed dividend related to a beneficial conversion feature
        		                                     0                            
          prepaid expenses and other current assets
        		                                  -1,578,000 -1,021,000 -2,354,000 -1,768,000 -492,000 -589,000 84,000     -24,993                    
          amortization of premium on investments
        		                                   9,000 28,000 -5,000                            
          tax payments related to shares witheld for vested restricted stock awards
        		                                   -1,157,000 -4,000 -288,000                            
          acquisitions of property, plant and equipment under accounts payable
        		                                                                 
          accounts payable and accrued expenses
        		                                      -1,682,000 2,776,000 200,000 -1,225,000 988,564 -44,521 248,957 656,302    -1,214,153     372,176 327,882 372,176      9,715 -1,284 17,061 
          fair value of vested stock options
        		                                       4,585,000 1,483,000 2,529,000 1,921,703 1,283,989 1,017,308 662,808     87,386  87,386             
          common stock issued for services
        		                                       772,000 296,000     430,384 17,700 423,054 17,700     750,000 50,000 0 50,000 -1,040,000 -2,426,548       
          liquidation (purchase) of money market funds
        		                                                                 
          proceeds from the issuance of common stock upon exercise of stock options
        		                                                                 
          proceeds from the issuance of preferred and common stock
        		                                                                 
          interest
        		                                                                 
          taxes
        		                                                                 
          purchase of money market funds
        		                                        -10,027,000                         
          common stock issued to induce exchange transaction
        		                                                 -122,733                
          common stock issued for lion transaction
        		                                                 9,956,250                
          common stock issued to directors
        		                                                 -1                
          increase in money market funds
        		                                         617,000 -13,085,145                       
          purchases of property and computer equipment
        		                                                                 
          proceeds from the issuance of convertible notes
        		                                                 0 300,000 11,500 300,000     2,320,000        
          proceeds from the issuance of preferred stock
        		                                                                 
          common stock issued upon conversion of convertible notes
        		                                                                 
          common stock issued upon conversion of accrued interest and penalty
        		                                                                 
          depreciation
        		                                                                 
          prepaid and other current assets
        		                                                                 
          purchases of property and equipment
        		                                          -72,867 -136,990 -782,143  -3,437  -3,437                 
          net cash used in investing activities
        		                                                                 
          net decrease in cash and cash equivalents
        		                                          -2,347,143            -510,217 15,739 -510,217         
          supplement non-cash financing activities
        		                                                                 
          prepaid expenses and deposits
        		                                           -249,526 -62,749                     
          common stock issued upon conversion of preferred stock
        		                                                                 
          proceeds from the issuance of common stock upon conversion of warrants
        		                                            2,304,250                     
          cash paid during the period for:
        		                                                                 
          income taxes
        		                                                                 
          common stock issued to induce conversion of warrants
        		                                                                 
          accounts payable to officers and former directors
        		                                                                 
          accrued interest and penalty
        		                                                 -8,821,898                
          settlement of accounts payable through issuance of common stock
        		                                                                 
          amortization of discount on convertible notes
        		                                                         2,401,575        
          deposits
        		                                                                 
          purchases of computer equipment and furniture
        		                                                                 
          net income
        		                                              -2,259,514    -1,046,529    -5,772,679      -564,296     
          adjustments to reconcile net income to net cash from operating activities:
        		                                                                 
          impairment of intangible asset
        		                                                                 
          fair value of vested stock options and warrants
        		                                              901,650 438,951 901,650 389,879    170,884 1,177,227 469,485 1,177,227 1,261,393 148,246       
          fair value of common stock and warrants accounted for as financing costs
        		                                                                 
          fair value of vested warrants granted for services
        		                                                                 
          private placement costs
        		                                                     4    0        
          change in fair value of derivative liabilities
        		                                                     -7,659,449 2,548,074 -1,927,838 2,548,074 1,645,405        
          common stock issued to officer for services
        		                                                         0        
          fair value of common stock transferred to officer and director
        		                                                                 
          write off of advances to related party
        		                                                                 
          deposits, prepaid expenses and other assets
        		                                              49,625 44,881 49,625 -164,838 -875 -985 -875  -20,186 25,422 -20,186         
          accounts payable, accrued expenses and other current liabilities
        		                                              -1,160,446 46,986 -1,160,446                 
          accrued compensation payable in shares of common stock
        		                                              167,057  167,057                 
          advances to related party
        		                                                         0 0 0 -50,000     
          proceeds from the issuance of secured promissory notes
        		                                                                 
          proceeds from issuance of common stock upon conversion of warrants
        		                                              542,500  542,500                 
          due to director
        		                                                              0   
          derivative liability recorded upon issuance of convertible
        		                                                                 
          notes and warrants
        		                                                      182,081  182,081         
          derivative liability recorded as offering cost
        		                                                                 
          common stock issued for intellectual property
        		                                                             0 0 0 217,408 
          forgiveness of debt by director, treated as contribution of capital
        		                                                                 
          fair value of common stock issued with notes payable recorded as
        		                                                                 
          a note discount
        		                                                                 
          the accompanying notes are an integral part of these financial statements.
        		                                                                 
          purchases of computer equipment
        		                                                 -1                
          adjustments to reconcile net loss to net cash from
        		                                                                 
          operating activities:
        		                                                                 
          fair value of common stock and warrants accounted
        		                                                                 
          for as financing costs
        		                                                                 
          fair value of common stock transferred to officer
        		                                                          0       
          and director
        		                                                                 
          common stock issued upon conversion of convertible notes,
        		                                                                 
          adjustments to reconcile net income to net cash used in
        		                                                                 
          bank overdraft
        		                                                      17,619  17,619         
          accounts payable, accrued expenses and interest and penalty
        		                                                  658,062  658,062             
          accrued expenses - national institute of health
        		                                                                 
          property and equipment
        		                                                         -10,737 -3,455       
          cash and cash equivalents, beginning of year
        		                                                      510,217  510,217         
          cash and cash equivalents, end of year
        		                                                                 
          forgiveness of debt by director, treated as contribution
        		                                                                 
          of capital
        		                                                                 
          common shares to be issued with 12% promissiory notes
        		                                                                 
          common stock issued conversion of warrants
        		                                                                 
          common stock issued for repricing shares
        		                                                                 
          fair value of derivative liability recorded upon issuance of warrants
        		                                                                 
          common stock issued with note payable reflected as financing cost
        		                                                                 
          proceeds from the issuance of promissory notes
        		                                                                 
          derivative liability recorded upon issuance of convertible notes and warrants
        		                                                                 
          derivative liability recorded as financing cost
        		                                                                 
          fair value of common stock issued with notes payable recorded as a note discount
        		                                                                 
          fair value of derivative liability recorded upon
        		                                                                 
          issuance of warrants
        		                                                                 
          amortization of discount on notes
        		                                                                 
          accrued expenses - national institutes of health
        		                                                      866,000  866,000         
          proceeds from convertible notes held in escrow
        		                                                                 
          deposit
        		                                                         8,109   -2,500     
          prepaid expenses
        		                                                         -4,473 2,500 5,292 -4,345 1,553 0   
          accounts payable and accrued liabilities
        		                                                         173,047 107,870 58,145 42,201     
          proceeds from convertible notes held in escrow account
        		                                                                 
          derivative liability recorded upon issuance of convertible notes and attached warrants
        		                                                                 
          derivative liability recorded as private placement cost
        		                                                          0       
          cash flows from operating activities:
        		                                                                 
          loss on website
        		                                                              0   
          change in fair value of derivative liability
        		                                                           398,556 -93,954     
          issuance of shares for services
        		                                                                 
          changes in operating assets and liabilities:
        		                                                                 
          cash flows from investing activities:
        		                                                                 
          cash flows from financing activities:
        		                                                                 
          proceeds from issuance of common stock
        		                                                           828,000 45,000     
          amortization of website
        		                                                                 
          amortization of intellectual property license
        		                                                            18,117     
          fair value of vesting of stock options
        		                                                            40,302 68,857 43,818   
          website
        		                                                              0   
          due from director
        		                                                                 
          forgiveness of debt by director treated as contribution of capital
        		                                                                 
          private placement cost.
        		                                                                 
          gain on fair value of derivative liability
        		                                                                 
          adjustment to reconcile net income to net cash from operating activities:
        		                                                                 
          amortization
        		                                                              174   
          fair value of derivative liability on issuance
        		                                                                 
          gain (loss) on fair value of derivative liability
        		                                                                 
          supplemental disclosures of non-cash investing and financing activities:
        		                                                                 
          taxes paid
        		                                                                 
          adjustment to reconcile net loss to net cash from operating activities:
        		                                                                 
          operating activities
        		                                                                 
          net income for the period
        		                                                                 
          adjustments to reconcile net income to net cash from operating activities
        		                                                                 
          amortization expense
        		                                                                 
          investing activities
        		                                                                 
          financing activities
        		                                                                 
          increase in cash during the period
        		                                                                 
          cash, beginning of the period
        		                                                                 
          cash, end of the period
        		                                                                 
          supplemental disclosure with respect to cash flows:
        		                                                                 
          cash paid for interest
        		                                                                 
          *