Quarterly
Annual
| Unit: USD | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2019-03-31 | 2018-12-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 | 2013-12-31 | 2013-09-30 | 2013-06-30 | 2013-03-31 | 2012-12-31 | 2012-09-30 | 2012-06-30 | 2012-03-31 | 2011-12-31 | 2011-09-30 | 2011-06-30 | 2011-03-31 | 2010-12-31 | 2010-09-30 | 2010-06-30 | 2010-03-31 | 2009-12-31 | 2009-09-30 | 2009-06-30 | 2009-03-31 | 2008-12-31 | 2008-09-30 | 2008-06-30 | 2008-03-31 | 2007-09-30 | 2007-06-30 | 2007-03-31 | 2006-12-31 | 2006-09-30 | 2006-06-30 | 2006-03-31 | 2005-12-31 | 2005-09-30 | 2005-06-30 | 2005-03-31 | 2004-09-30 | 2004-06-30 | 2004-03-31 | 2003-12-31 |
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assets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current assets: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents | 338,341,000 | 297,304,000 | 264,192,000 | 242,077,000 | 334,605,000 | 293,993,000 | 348,889,000 | 399,266,000 | 352,060,000 | 424,790,000 | 309,031,000 | 276,472,000 | 314,993,000 | 521,917,000 | 542,513,000 | 375,811,000 | 278,820,000 | 73,220,000 | 94,081,000 | 161,778,000 | 159,973,000 | 256,408,000 | 296,540,000 | 107,650,000 | 124,482,000 | 84,563,000 | 85,645,000 | 56,391,000 | 65,477,000 | 55,263,000 | 85,022,000 | 86,200,000 | 70,052,000 | 100,122,000 | 46,038,000 | 98,590,000 | 105,255,000 | 149,293,000 | 215,789,000 | 254,057,000 | 217,918,000 | 264,682,000 | 445,720,000 | 271,936,000 | 102,398,000 | 132,964,000 | 183,423,000 | 114,514,000 | 104,238,000 | 105,359,000 | 1,711,000 | 3,650 | 53,222,000 | 7,988,000 | 12,006,000 | 21,446,000 | 30,371,000 | 39,757,000 | |
short-term investments | 1,901,830,000 | 1,992,676,000 | 1,880,960,000 | 2,055,579,000 | 2,148,671,000 | 1,784,693,000 | 1,857,327,000 | 1,931,935,000 | 1,883,522,000 | 1,960,598,000 | 2,037,750,000 | 1,710,397,000 | 1,666,670,000 | 1,499,910,000 | 1,509,880,000 | 1,877,943,000 | 1,805,252,000 | 518,766,000 | 496,754,000 | 469,515,000 | 496,788,000 | 414,490,000 | 294,212,000 | 264,261,000 | 249,964,000 | 259,010,000 | 250,384,000 | 277,553,000 | 278,187,000 | 309,500,000 | 310,162,000 | 340,622,000 | 402,301,000 | 397,782,000 | 475,990,000 | 420,529,000 | 469,057,000 | 458,547,000 | 421,722,000 | 398,179,000 | 273,080,000 | 247,341,000 | 91,249,000 | 66,479,000 | 43,593,000 | 69,769,000 | 102,131,000 | 78,819,000 | 22,633,000 | 32,581,000 | 76,850,000 | 90,739 | 48,435,000 | 51,592,000 | 70,778,000 | 104,119,000 | 116,973,000 | 141,116,000 | |
contracts receivable | 24,608,000 | 52,580,000 | 39,707,000 | 92,188,000 | 17,928,000 | 27,259,000 | 5,140,000 | 97,778,000 | 142,359,000 | 27,956,000 | 13,914,000 | 25,538,000 | 6,645,000 | 6,751,000 | 26,122,000 | 10,452,000 | 12,759,000 | 26,313,000 | 41,941,000 | 9,823,000 | 11,102,000 | 12,645,000 | 2,024,000 | 1,172,000 | 522,000 | 3,476,000 | 1,558,000 | 1,379,000 | 6,921,000 | 1,858,000 | 5,674,000 | 591,000 | 1,242,000 | 1,341,000 | 5,040,000 | 1,904,000 | 10,899,000 | 586,000 | 783,000 | 2,351,000 | 4,121,000 | 5,021,000 | 6,399,000 | 4,358,000 | 9,237,000 | 2,296,000 | 2,057,000 | 2,395,000 | 2,959,000 | 2,618,000 | 3,503,000 | 3,918 | 4,209,000 | 4,456,000 | 2,911,000 | 5,464,000 | 9,593,000 | 5,774,000 | |
inventories | 10,470,000 | 8,481,000 | 11,502,000 | 12,512,000 | 28,452,000 | 28,723,000 | 30,259,000 | 28,425,000 | 25,634,000 | 25,538,000 | 22,200,000 | 22,033,000 | 20,645,000 | 19,811,000 | 24,032,000 | 11,057,000 | 8,582,000 | 7,085,000 | 7,776,000 | 7,537,000 | 8,033,000 | 7,385,000 | 8,309,000 | 5,809,000 | 6,121,000 | 6,737,000 | 7,108,000 | 4,873,000 | 4,139,000 | 2,915,000 | 2,249,000 | 2,606,000 | 2,484,000 | 1,996,000 | 2,794,000 | 2,601,000 | 2,768,000 | 2,817,000 | 2,779,000 | 2,591,000 | 2,718,000 | 5,511,000 | 4,699,000 | 3,700,000 | 1,930,000 | 1,510,000 | |||||||||||||
other current assets | 243,744,000 | 226,109,000 | 222,571,000 | 217,934,000 | 184,194,000 | 194,715,000 | 174,060,000 | 184,449,000 | 181,075,000 | 177,872,000 | 159,724,000 | 168,254,000 | 143,173,000 | 142,759,000 | 150,577,000 | 98,686,000 | 102,473,000 | 8,353,000 | 8,567,000 | 9,814,000 | 7,518,000 | 7,372,000 | 5,786,000 | 8,074,000 | 8,727,000 | 7,800,000 | 5,724,000 | 7,417,000 | 5,415,000 | 7,553,000 | 7,613,000 | 7,376,000 | 7,058,000 | 6,309,000 | 7,023,000 | 6,791,000 | 8,147,000 | 8,004,000 | 6,439,000 | 6,514,000 | 5,085,000 | 6,988,000 | 7,113,000 | 6,378,000 | 4,229,000 | 4,238,000 | 7,363,000 | 9,614,000 | 6,461,000 | 6,830,000 | 7,918,000 | 6,600 | 7,459,000 | 7,260,000 | 8,574,000 | 8,236,000 | 9,281,000 | 7,686,000 | |
total current assets | 2,518,993,000 | 2,577,150,000 | 2,418,932,000 | 2,620,290,000 | 2,713,850,000 | 2,329,383,000 | 2,415,675,000 | 2,641,853,000 | 2,584,650,000 | 2,616,754,000 | 2,542,619,000 | 2,202,694,000 | 2,152,126,000 | 2,191,148,000 | 2,253,124,000 | 2,373,949,000 | 2,207,886,000 | 681,163,000 | 705,797,000 | 722,053,000 | 735,510,000 | 763,304,000 | 669,061,000 | 431,829,000 | 423,438,000 | 361,586,000 | 350,419,000 | 347,613,000 | 360,139,000 | 377,089,000 | 410,720,000 | 437,395,000 | 483,137,000 | 507,550,000 | 536,885,000 | 530,415,000 | 596,126,000 | 619,247,000 | 647,512,000 | 663,692,000 | 518,384,000 | 529,543,000 | 555,180,000 | 352,851,000 | 161,387,000 | 210,777,000 | 296,067,000 | 206,203,000 | 136,923,000 | 148,274,000 | 90,731,000 | 105,858 | 114,242,000 | 72,367,000 | 96,991,000 | 159,355,000 | 182,292,000 | 208,881,000 | |
property, plant and equipment | 106,117,000 | 111,951,000 | 102,925,000 | 94,251,000 | 82,502,000 | 75,902,000 | 72,795,000 | 71,043,000 | 70,928,000 | 91,634,000 | 85,158,000 | 74,294,000 | 180,806,000 | 177,015,000 | 177,724,000 | 133,519,000 | 132,160,000 | 88,068,000 | 86,321,000 | 86,641,000 | 86,198,000 | 87,273,000 | 88,312,000 | 89,694,000 | 91,084,000 | 92,598,000 | 94,008,000 | 95,132,000 | 96,615,000 | 98,019,000 | 88,010,000 | 37,680,000 | 35,703,000 | 35,549,000 | 36,071,000 | 36,171,000 | 27,338,000 | 26,911,000 | 26,636,000 | 24,183,000 | 17,371,000 | 14,019,000 | 10,494,000 | 8,274,000 | 6,583,000 | 6,890,000 | 7,042,000 | 7,157,000 | 7,227,000 | 7,563,000 | 8,208,000 | 9,130 | 10,181,000 | 22,837,000 | 26,665,000 | 30,857,000 | 32,172,000 | 32,721,000 | |
right-of-use assets | 241,993,000 | 163,933,000 | 159,269,000 | 161,856,000 | 164,424,000 | 166,939,000 | 169,431,000 | 171,896,000 | 174,310,000 | 176,718,000 | 179,148,000 | 181,544,000 | |||||||||||||||||||||||||||||||||||||||||||||||
deposits and other assets | 165,988,000 | 132,099,000 | 131,822,000 | 127,278,000 | 120,323,000 | 118,904,000 | 106,027,000 | 105,280,000 | 104,083,000 | 86,025,000 | 78,296,000 | 75,344,000 | 59,434,000 | 58,916,000 | 58,949,000 | 25,954,000 | 12,910,000 | 4,533,000 | 5,299,000 | 5,438,000 | 5,359,000 | 5,481,000 | 5,601,000 | 5,824,000 | 5,939,000 | 6,126,000 | 2,460,000 | 2,570,000 | 2,845,000 | 3,121,000 | 3,269,000 | 3,398,000 | 3,528,000 | 3,658,000 | 3,789,000 | 3,211,000 | 3,269,000 | 3,441,000 | 3,590,000 | 3,739,000 | 5,274,000 | 5,557,000 | 7,229,000 | 2,854,000 | 2,806,000 | 2,809,000 | 2,797,000 | 4,276,000 | 2,433,000 | 2,667,000 | 2,883,000 | 3,201 | 3,359,000 | 3,220,000 | 3,422,000 | 8,052,000 | 8,253,000 | 8,411,000 | |
total assets | 3,033,091,000 | 2,985,133,000 | 2,812,948,000 | 3,003,675,000 | 3,081,099,000 | 2,691,128,000 | 2,763,928,000 | 2,990,072,000 | 2,933,971,000 | 2,971,131,000 | 2,885,221,000 | 2,533,876,000 | 2,421,971,000 | 2,456,133,000 | 2,519,092,000 | 2,835,889,000 | 2,667,784,000 | 793,803,000 | 817,777,000 | 834,616,000 | 847,156,000 | 881,916,000 | 788,651,000 | 552,961,000 | 545,686,000 | 485,681,000 | 472,394,000 | 470,807,000 | 484,894,000 | 505,785,000 | 529,572,000 | 505,942,000 | 550,477,000 | 575,858,000 | 606,351,000 | 599,723,000 | 657,184,000 | 680,578,000 | 709,161,000 | 724,506,000 | 574,150,000 | 584,692,000 | 609,399,000 | 405,424,000 | 213,003,000 | 263,255,000 | 349,904,000 | 255,907,000 | 187,768,000 | 201,919,000 | 150,637,000 | 166,373 | 177,382,000 | 146,526,000 | 175,648,000 | 255,271,000 | 279,962,000 | 312,726,000 | |
liabilities and stockholders’ equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
current liabilities: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accounts payable | 14,326,000 | 22,800,000 | 17,456,000 | 42,964,000 | 9,052,000 | 9,243,000 | 13,082,000 | 26,027,000 | 5,615,000 | 24,021,000 | 10,499,000 | 17,921,000 | 20,545,000 | 10,351,000 | 16,125,000 | 13,332,000 | 28,660,000 | 15,627,000 | 13,453,000 | 9,869,000 | 11,009,000 | 8,781,000 | 9,461,000 | 5,385,000 | 10,239,000 | 5,256,000 | 6,194,000 | 5,344,000 | 8,300,000 | 6,653,000 | 3,071,000 | 4,652,000 | 6,523,000 | 3,392,000 | 5,355,000 | 4,843,000 | 4,696,000 | 5,554,000 | 6,659,000 | 7,445,000 | 5,710,000 | 6,885,000 | 5,716,000 | 5,633,000 | 4,507,000 | 4,161,000 | 3,274,000 | 4,288,000 | 3,003,000 | 3,267,000 | 2,483,000 | 2,095 | 2,833,000 | 2,297,000 | 2,240,000 | 2,818,000 | 3,416,000 | 3,349,000 | |
accrued compensation | 57,019,000 | 46,564,000 | 26,575,000 | 69,614,000 | 40,558,000 | 35,018,000 | 21,537,000 | 67,727,000 | 33,781,000 | 29,322,000 | 18,160,000 | 49,178,000 | 30,410,000 | 24,985,000 | 16,525,000 | 16,264,000 | 29,268,000 | 7,164,000 | 6,430,000 | 4,328,000 | 12,168,000 | 6,653,000 | 7,031,000 | 3,818,000 | 7,878,000 | 5,836,000 | 4,939,000 | 3,502,000 | 9,183,000 | 5,233,000 | 4,406,000 | 3,076,000 | 6,831,000 | 4,833,000 | 4,312,000 | 2,971,000 | 7,135,000 | 4,763,000 | 4,460,000 | 3,181,000 | 6,835,000 | 3,956,000 | 3,631,000 | 2,449,000 | 4,920,000 | 2,379,000 | 2,017,000 | 6,222,000 | 1,332,000 | 1,628,000 | 1,517,000 | 3,706 | 1,306,000 | 1,736,000 | 1,811,000 | 3,819,000 | 3,033,000 | 2,058,000 | |
accrued liabilities | 99,310,000 | 98,957,000 | 102,735,000 | 108,438,000 | 124,396,000 | 114,330,000 | 106,048,000 | 147,894,000 | 118,968,000 | 104,745,000 | 112,702,000 | 140,101,000 | 128,002,000 | 134,336,000 | 99,256,000 | 45,130,000 | 48,361,000 | 29,140,000 | 25,166,000 | 27,903,000 | 22,092,000 | 22,283,000 | 16,514,000 | 17,758,000 | 15,401,000 | 11,900,000 | 15,619,000 | 15,600,000 | 18,655,000 | 15,071,000 | 10,873,000 | 8,134,000 | 12,389,000 | 10,285,000 | 13,302,000 | 9,371,000 | 12,339,000 | 7,491,000 | 8,422,000 | 7,750,000 | 9,556,000 | 5,979,000 | 7,441,000 | 5,301,000 | 5,278,000 | 5,094,000 | 7,300,000 | 6,071,000 | 6,846,000 | 6,932,000 | 7,871,000 | 8,643 | 10,042,000 | 7,988,000 | 11,902,000 | 10,430,000 | 7,900,000 | 8,049,000 | |
income taxes payable | 101,000 | 81,000 | 126,000 | 34,000 | 41,000 | 284,000 | 2,210,000 | 2,151,000 | 31,070,000 | 24,732,000 | 17,286,000 | 6,249,000 | 16,000 | 14,000 | 901,000 | 18,401,000 | 7,323,000 | 15,864,000 | 23,233,000 | 29,627,000 | |||||||||||||||||||||||||||||||||||||||
0 percent convertible senior notes | 630,911,000 | 630,118,000 | 629,326,000 | 628,535,000 | 627,745,000 | 626,955,000 | 626,167,000 | 625,380,000 | 624,594,000 | 623,809,000 | 623,025,000 | 622,242,000 | 621,460,000 | 620,678,000 | 619,898,000 | ||||||||||||||||||||||||||||||||||||||||||||
current portion of deferred contract revenue | 76,986,000 | 75,910,000 | 81,097,000 | 78,989,000 | 76,018,000 | 94,066,000 | 130,406,000 | 151,128,000 | 204,824,000 | 96,252,000 | 92,335,000 | 90,577,000 | 99,511,000 | 93,393,000 | 91,437,000 | 144,846,000 | 160,256,000 | 51,727,000 | 51,560,000 | 54,428,000 | 48,135,000 | 55,977,000 | 40,409,000 | 35,244,000 | 35,925,000 | 23,427,000 | 22,998,000 | 34,320,000 | 36,584,000 | 52,428,000 | 68,719,000 | 73,392,000 | 74,502,000 | 77,268,000 | 77,268,000 | 70,890,000 | 75,681,000 | 76,941,000 | 82,092,000 | 85,581,000 | 92,662,000 | 99,794,000 | 101,507,000 | 57,951,000 | 7,804,000 | 6,070,000 | 1,043,000 | 1,044,000 | 571,000 | 712,000 | 1,111,000 | 1,514 | 1,410,000 | 4,926,000 | 10,435,000 | 15,801,000 | 17,523,000 | 15,832,000 | |
other current liabilities | 24,803,000 | 22,806,000 | 22,304,000 | 9,279,000 | 10,034,000 | 8,799,000 | 9,988,000 | 8,831,000 | 9,952,000 | 8,903,000 | 8,239,000 | 7,535,000 | |||||||||||||||||||||||||||||||||||||||||||||||
total current liabilities | 903,456,000 | 897,236,000 | 250,293,000 | 309,318,000 | 304,566,000 | 306,162,000 | 327,648,000 | 448,090,000 | 404,210,000 | 287,975,000 | 259,221,000 | 311,561,000 | 283,454,000 | 267,811,000 | 228,450,000 | 252,473,000 | 280,294,000 | 107,325,000 | 100,816,000 | 100,836,000 | 97,812,000 | 103,278,000 | 86,995,000 | 70,295,000 | 74,322,000 | 51,601,000 | 55,063,000 | 61,707,000 | 76,112,000 | 83,542,000 | 91,980,000 | 94,399,000 | 105,890,000 | 100,916,000 | 105,214,000 | 92,095,000 | 111,444,000 | 114,719,000 | 127,861,000 | 136,460,000 | 124,698,000 | 117,683,000 | 127,111,000 | 80,260,000 | 29,966,000 | 25,178,000 | 101,941,000 | 25,139,000 | 19,436,000 | 20,281,000 | 20,845,000 | 23,793 | 23,905,000 | 26,053,000 | 36,062,000 | 42,897,000 | 42,132,000 | 39,643,000 | |
long-term deferred contract revenue | 107,906,000 | 125,095,000 | 140,678,000 | 156,504,000 | 173,776,000 | 188,701,000 | 215,088,000 | 241,184,000 | 249,272,000 | 254,398,000 | 272,973,000 | 287,768,000 | 294,656,000 | 315,196,000 | 333,138,000 | 542,416,000 | 567,359,000 | 110,614,000 | 120,387,000 | 130,755,000 | 142,790,000 | 151,006,000 | 75,184,000 | 58,816,000 | 66,656,000 | 36,961,000 | 31,715,000 | 35,469,000 | 17,474,000 | 19,415,000 | 21,356,000 | 32,065,000 | 50,413,000 | 70,900,000 | 90,164,000 | 81,457,000 | 107,097,000 | 125,237,000 | 143,376,000 | 154,293,000 | 172,766,000 | 191,279,000 | 214,202,000 | 84,798,000 | 8,131,000 | 9,310,000 | 143,000 | 44,000 | |||||||||||
1.75 percent convertible senior notes | 567,123,000 | 566,420,000 | 565,721,000 | 565,026,000 | 564,335,000 | 563,647,000 | 562,964,000 | 562,285,000 | 561,609,000 | 560,937,000 | |||||||||||||||||||||||||||||||||||||||||||||||||
liability related to sale of future royalties | 545,182,000 | 541,205,000 | 536,141,000 | 542,212,000 | 538,102,000 | 533,754,000 | 525,072,000 | 513,736,000 | 512,700,000 | 510,174,000 | 505,081,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
long-term lease liabilities | 262,672,000 | 164,379,000 | 159,392,000 | 161,805,000 | 168,372,000 | 166,438,000 | 168,674,000 | 170,875,000 | 173,038,000 | 175,020,000 | 177,000,000 | 178,941,000 | |||||||||||||||||||||||||||||||||||||||||||||||
long-term obligations | 28,785,000 | 59,074,000 | 55,671,000 | 51,924,000 | 41,735,000 | 41,773,000 | 41,800,000 | 41,836,000 | 48,801,000 | 16,436,000 | 7,487,000 | 7,126,000 | |||||||||||||||||||||||||||||||||||||||||||||||
total liabilities | 2,415,124,000 | 2,353,409,000 | 2,337,222,000 | 2,415,324,000 | 2,418,631,000 | 2,427,430,000 | 2,467,413,000 | 2,603,386,000 | 2,618,511,000 | 2,542,830,000 | 2,398,651,000 | 1,960,989,000 | 1,827,610,000 | 1,831,407,000 | 1,809,518,000 | 1,448,469,000 | 1,480,624,000 | 449,031,000 | 450,917,000 | 460,514,000 | 468,766,000 | 480,470,000 | 387,570,000 | 351,870,000 | 362,920,000 | 315,404,000 | 318,080,000 | 319,935,000 | 313,460,000 | 318,960,000 | 317,355,000 | 278,239,000 | 305,935,000 | 322,149,000 | 344,122,000 | 315,286,000 | 355,119,000 | 375,753,000 | 403,344,000 | 421,836,000 | 469,902,000 | 476,940,000 | 509,228,000 | 327,949,000 | 202,819,000 | 201,041,000 | 270,473,000 | 158,005,000 | 154,172,000 | 156,454,000 | 173,342,000 | ||||||||
stockholders’ equity: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
common stock | 161,000 | 159,000 | 159,000 | 158,000 | 158,000 | 146,000 | 146,000 | 144,000 | 143,000 | 143,000 | 143,000 | 142,000 | 142,000 | 142,000 | 142,000 | 140,000 | 138,000 | 118,000 | 118,000 | 118,000 | 116,000 | 116,000 | 114,000 | 103,000 | 102,000 | 102,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 100,000 | 99,000 | 99,000 | 99,000 | 99,000 | 99,000 | 98,000 | 98,000 | 98,000 | 97,000 | 96,000 | 95,000 | 93,000 | 87,000 | 82,000 | 82,000 | 82,000 | 74,000 | 73,000 | 73,000 | 72 | 72,000 | 58,000 | 58,000 | 57,000 | 57,000 | 56,000 | |
additional paid-in capital | 3,045,585,000 | 2,932,747,000 | 2,901,262,000 | 2,868,812,000 | 2,831,942,000 | 2,303,369,000 | 2,270,047,000 | 2,215,098,000 | 2,148,002,000 | 2,118,309,000 | 2,089,358,000 | 2,059,850,000 | 2,034,554,000 | 2,008,794,000 | 1,983,078,000 | 2,117,969,000 | 2,047,250,000 | 1,365,407,000 | 1,352,994,000 | 1,343,874,000 | 1,324,804,000 | 1,315,643,000 | 1,292,745,000 | 1,091,842,000 | 1,077,150,000 | 1,073,658,000 | 1,019,936,000 | 1,016,497,000 | 1,013,592,000 | 1,009,330,000 | 1,006,288,000 | 1,003,595,000 | 1,000,181,000 | 995,149,000 | 991,436,000 | 988,053,000 | 985,620,000 | 978,411,000 | 972,697,000 | 967,648,000 | 905,721,000 | 900,303,000 | 890,435,000 | 884,434,000 | 820,422,000 | 887,579,000 | 884,506,000 | 880,954,000 | 802,063,000 | 795,026,000 | 774,366,000 | 770,263 | 764,555,000 | 623,385,000 | 623,361,000 | 622,395,000 | 622,106,000 | 610,517,000 | |
accumulated other comprehensive income | 16,894,000 | 24,719,000 | 29,000,000 | 21,080,000 | 29,021,000 | 12,480,000 | 399,000 | 689,000 | 949,000 | 1,162,000 | 941,000 | 1,379,000 | 2,153,000 | 3,678,000 | 2,324,000 | 473,000 | 982,000 | 2,730,000 | 2,123,000 | 511,000 | 418,000 | 2,081,000 | 4,278,000 | 2,045,000 | 2,114,000 | 5,739,000 | 3,178 | 2,349,000 | 141,000 | 544,000 | 956,000 | 4,747,000 | |||||||||||||||||||||||||||
accumulated deficit | -2,396,746,000 | -2,249,808,000 | -2,145,459,000 | -2,004,979,000 | -1,938,714,000 | -1,795,911,000 | -1,786,648,000 | -1,639,238,000 | -1,553,948,000 | -1,429,625,000 | -1,377,195,000 | -1,330,203,000 | -1,225,068,000 | -882,850,000 | -967,293,000 | -1,037,647,000 | -1,010,971,000 | -998,890,000 | -840,795,000 | ||||||||||||||||||||||||||||||||||||||||
total stockholders' equity | 617,967,000 | 631,724,000 | 366,860,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities and stockholders’ equity | 3,033,091,000 | 2,985,133,000 | 2,812,948,000 | 3,003,675,000 | 3,081,099,000 | 2,691,128,000 | 2,763,928,000 | 2,990,072,000 | 2,933,971,000 | 2,971,131,000 | 2,885,221,000 | 2,533,876,000 | 2,421,971,000 | 2,456,133,000 | 2,519,092,000 | 2,835,889,000 | 2,667,784,000 | 793,803,000 | 834,616,000 | 847,156,000 | 881,916,000 | 788,651,000 | 552,961,000 | 545,686,000 | 485,681,000 | 472,394,000 | 470,807,000 | 484,894,000 | 505,785,000 | 529,572,000 | 505,942,000 | 550,477,000 | 575,858,000 | 606,351,000 | 599,723,000 | 657,184,000 | 680,578,000 | 709,161,000 | 724,506,000 | 150,637,000 | 166,373 | 177,382,000 | 255,271,000 | 279,962,000 | 312,726,000 | ||||||||||||||
accumulated other comprehensive loss | -28,949,000 | -30,811,000 | -24,173,000 | -34,838,000 | -34,964,000 | -32,645,000 | -46,037,000 | -50,913,000 | -48,983,000 | -57,480,000 | -63,140,000 | -54,007,000 | -48,578,000 | -27,608,000 | -32,016,000 | ||||||||||||||||||||||||||||||||||||||||||||
total stockholders’ equity | 475,726,000 | 588,351,000 | 662,468,000 | 263,698,000 | 296,515,000 | 386,686,000 | 315,460,000 | 428,301,000 | 486,570,000 | 572,887,000 | 594,361,000 | 624,726,000 | 709,574,000 | 1,387,420,000 | 1,187,160,000 | 344,772,000 | 374,102,000 | 378,390,000 | 401,446,000 | 401,081,000 | 201,091,000 | 182,766,000 | 170,277,000 | 154,314,000 | 150,872,000 | 171,434,000 | 186,825,000 | 212,217,000 | 227,703,000 | 244,542,000 | 253,709,000 | 262,229,000 | 284,437,000 | 302,065,000 | 304,825,000 | 305,817,000 | 302,670,000 | 67,092,000 | 68,078,000 | 59,023,000 | 54,621,000 | 232,000 | 47,284,000 | 56,898,000 | 68,563,000 | 1,577,000 | 6,713,000 | 2,665 | 4,040,000 | 11,611,000 | 47,554,000 | ||||||||
0.125 percent convertible senior notes | 44,467,000 | 44,422,000 | 44,377,000 | 44,332,000 | 44,287,000 | 114,081,000 | 545,053,000 | 544,504,000 | 543,955,000 | 543,407,000 | 542,860,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
long-term mortgage debt | 8,811,000 | 8,847,000 | 58,978,000 | 59,222,000 | 59,462,000 | 59,860,000 | 59,842,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
patents | 29,605,000 | 29,054,000 | 29,295,000 | 25,220,000 | 24,032,000 | 16,879,000 | 16,729,000 | 16,383,000 | 15,517,000 | 20,810,000 | 20,149,000 | 19,604,000 | 18,646,000 | 18,180,000 | 17,701,000 | 17,071,000 | 16,259,000 | 16,994,000 | 16,444,000 | 15,773,000 | 15,821,000 | 16,208,000 | 16,152,000 | 15,919,000 | 15,909,000 | 15,851,000 | 15,709,000 | 16,616,000 | 16,260,000 | 18,126,000 | 18,538,000 | 18,390,000 | 17,605,000 | 17,376,000 | 17,037,000 | 16,836,000 | 17,042,000 | 18,688,000 | 18,875,000 | 18,773 | 20,148,000 | 19,869,000 | 19,745,000 | 25,981,000 | 24,691,000 | 23,556,000 | |||||||||||||
current portion of long-term obligations | 4,970,000 | 4,732,000 | 4,206,000 | 14,500,000 | 13,749,000 | 3,667,000 | 4,207,000 | 4,308,000 | 4,408,000 | 4,649,000 | 4,853,000 | 4,508,000 | 4,879,000 | 5,182,000 | 5,313,000 | 2,941,000 | 3,390,000 | 4,157,000 | 4,911,000 | 5,145,000 | 5,645,000 | 5,138,000 | 4,977,000 | 4,020,000 | 4,270,000 | 4,106,000 | 2,995,000 | 2,876,000 | 2,065,000 | 3,669,000 | 5,471,000 | 7,457,000 | 7,474,000 | 7,482,000 | 7,514,000 | 7,684,000 | 7,742,000 | 7,863,000 | 7,835 | 8,314,000 | 9,106,000 | 9,674,000 | 10,029,000 | 10,260,000 | 10,355,000 | ||||||||||||||
long-term obligations, less current portion | 25,107,000 | 25,093,000 | 25,710,000 | 16,305,000 | 4,914,000 | 4,039,000 | 4,510,000 | 5,523,000 | 6,542,000 | 6,384,000 | 7,382,000 | 6,498,000 | 7,402,000 | 8,404,000 | 9,503,000 | 3,603,000 | 4,125,000 | 4,724,000 | 5,465,000 | 4,938,000 | 5,720,000 | 4,304,000 | 5,620,000 | 4,474,000 | 11,478,000 | 12,532,000 | 10,643,000 | 11,370,000 | 9,938,000 | 5,478,000 | 5,415,000 | 391,000 | 2,222,000 | 4,053,000 | 5,889,000 | 7,822,000 | 9,736,000 | 11,173,000 | 12,942,000 | 14,915 | 16,845,000 | 119,432,000 | 118,358,000 | 104,369,000 | 99,033,000 | 94,558,000 | |||||||||||||
long-term deferred tax assets | 277,247,000 | 290,796,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 percent convertible senior notes | 577,415,000 | 568,215,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total ionis stockholders’ equity | 1,207,651,000 | 1,048,079,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncontrolling interest in akcea therapeutics, inc. | 179,769,000 | 139,081,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
investment in regulus therapeutics inc. | 47,426,000 | 56,678,000 | 63,586,000 | 52,096,000 | 65,004,000 | 62,190,000 | 44,863,000 | 33,622,000 | 5,563,000 | 5,563,000 | 5,400,000 | 4,424,000 | 3,145,000 | 2,759,000 | 1,726,000 | 870,000 | 5,000,000 | 4,070,000 | 127,000 | ||||||||||||||||||||||||||||||||||||||||
licenses | 3,160,000 | 3,631,000 | 4,101,000 | 4,572,000 | 5,048,000 | 5,528,000 | 6,010,000 | 6,579,000 | 7,191,000 | 7,806,000 | 8,421,000 | 9,036,000 | 10,562,000 | 11,129,000 | 11,696,000 | 12,288,000 | 12,893,000 | 13,454,000 | 14,007,000 | 14,542,000 | 15,128,000 | 15,714,000 | 16,276,000 | 16,861,000 | 17,447,000 | 17,958,000 | 18,516,000 | 19,684,000 | 20,267,000 | 20,851,000 | 21,435,000 | 22,018,000 | 22,602,000 | 23,186,000 | 23,770 | 24,353,000 | 24,937,000 | 25,521,000 | 26,619,000 | 27,200,000 | 27,782,000 | ||||||||||||||||||
2¾ percent convertible senior notes | 155,437,000 | 152,005,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term financing liability for leased facility | 71,616,000 | 71,504,000 | 71,395,000 | 71,288,000 | 71,097,000 | 70,910,000 | 70,728,000 | 70,550,000 | 70,375,000 | 70,205,000 | 70,039,000 | 69,877,000 | 68,895,000 | 58,722,000 | |||||||||||||||||||||||||||||||||||||||||||||
liabilities and stockholders' equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
23/4 percent convertible senior notes | 153,700,000 | 148,705,000 | 147,099,000 | 145,533,000 | 142,500,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders' equity: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities and stockholders' equity | 817,777,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
23¤4 percent convertible senior notes | 150,334,000 | 143,990,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accrued income taxes | 4,935,000 | 8,727,000 | 3,582,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive gain | 26,986,000 | 17,784,000 | 846,000 | 968,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
25¤8 percent convertible subordinated notes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
25/8 percent convertible subordinated notes | 146,031,000 | 143,717,000 | 141,448,000 | 139,239,000 | 134,964,000 | 132,895,000 | 125,100,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
25/8% convertible subordinated notes | 137,073,000 | 130,882,000 | 128,907,000 | 126,986,000 | 123,265,000 | 121,464,000 | 119,713,000 | 162,500,000 | 162,500,000 | 162,500,000 | 162,500,000 | ||||||||||||||||||||||||||||||||||||||||||||||||
long-term financing obligation | 10,147,000 | 10,147,000 | 10,147,000 | 10,147,000 | 10,147,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
total isis pharmaceuticals, inc. stockholders’ equity | 244,542,000 | 253,709,000 | 262,229,000 | 284,437,000 | 291,722,000 | 292,995,000 | 292,851,000 | 288,846,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||
noncontrolling interest in regulus therapeutics inc. | 10,343,000 | 11,830,000 | 12,966,000 | 13,824,000 | 4,737,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
assets from discontinued operations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities from discontinued operations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncontrolling interest in ibis biosciences, inc. — discontinued operations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
assets held for sale | 15,462,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities held for sale | 7,870,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncontrolling interest in ibis biosciences, inc. — held for sale. | 32,419,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities, noncontrolling interest and stockholders’ equity | 574,150,000 | 584,692,000 | 609,399,000 | 405,424,000 | 213,003,000 | 263,255,000 | 349,904,000 | 255,907,000 | 187,768,000 | 201,919,000 | |||||||||||||||||||||||||||||||||||||||||||||||||
derivative instrument related to abbott’s call option | 1,069,000 | 5,147,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncontrolling interest in regulus therapeutics llc | 6,315,000 | 7,523,000 | 8,488,000 | 9,952,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncontrolling interest in ibis biosciences, inc. | 33,359,000 | 33,625,000 | 14,366,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
debt issuance costs | 4,539,000 | 4,938,000 | 5,136,000 | 6,110,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
derivative instruments related to abbott’s subscription right and call option | 3,455,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
25¤8% convertible subordinated notes | 162,500,000 | 162,500,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
5 1/2% convertible subordinated notes | 125,000,000 | 125,000,000 | 125,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
2 5/8% convertible subordinated notes | 162,500,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncontrolling interest in symphony genisis, inc. | 29,339,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
51/2% convertible subordinated notes | 125,000 | 125,000,000 | 125,000,000 | 125,000,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
noncontrolling interest in symphony genisis, inc | 14,930,000 | 22,533,000 | 32,019,000 | 38,752,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
inventory | 1,093,000 | 861,000 | 632,000 | 886,000 | 749,000 | 951 | 917,000 | 1,071,000 | 2,722,000 | 20,090,000 | 16,074,000 | 14,548,000 | |||||||||||||||||||||||||||||||||||||||||||||||
current portion of 51¤2% convertible subordinated notes | 80,825,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
51¤2% convertible subordinated notes | 125,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term investments | 2,125,000 | 2,125,000 | 6,754,000 | 5,099,000 | 3,296,000 | 3,304,000 | 4,407,000 | 5,354,000 | 11,375,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ equity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
investments in corporate securities | 5,641 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
long-term deferred contract revenue, less current portion | 92,000 | 230,000 | 378,000 | 644,000 | 2,186,000 | 5,971,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
deferred compensation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
common stock warrants | 7,500,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
liabilities and stockholders’ deficit | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ deficit: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total stockholders’ deficit | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities and stockholders’ deficit | 146,526,000 | 175,648,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
revenue: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
research and development revenue under collaborative agreements | 10,438,000 | 7,135,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
licensing and royalty revenue | 154,000 | 307,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total revenue | 10,592,000 | 7,442,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
operating expenses: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
research and development | 20,950,000 | 22,361,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
general and administrative | 1,910,000 | 2,137,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
compensation benefit related to stock options | 5,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
restructuring activities | 650,000 | 7,084,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
total operating expenses | 23,515,000 | 30,949,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
income from operations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
other income | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
investment income | 349,000 | 504,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
interest expense | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accretion of dividends on preferred stock | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
net income applicable to common stock | -19,659,000 | -29,658,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
basic and diluted net income per share | -340 | -520 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
shares used in computing basic and diluted net income per share | 57,524,000 | 57,521,000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
5 ½% convertible subordinated notes | 125,000,000 | 125,000,000 | 125,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
series b convertible exchangeable 5% preferred stock, 0.001 par value; 4,605 shares authorized, no shares issued or outstanding at september 30, 2004; 16,620 shares authorized, 12,015 shares issued and outstanding at december 31, 2003 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
accretion of series b preferred stock dividends | 2,741,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
series b convertible exchangeable 5% preferred stock, 0.001 par value; 4,605 shares authorized, no shares issued or outstanding at june 30, 2004; 16,620 shares authorized, 12,015 shares issued and outstanding at december 31, 2003 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
series b convertible exchangeable 5% preferred stock, .001 par value; 16,620 shares authorized, 12,015 shares issued and outstanding at march 31, 2004 and december 31, 2003 | 12,015,000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
results of operations: |
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