Incyte Corporation
(NASDAQ:INCY)

Incyte Corporation, a biopharmaceutical company, focuses on the discovery, development, and commercialization of proprietary therapeutics in the United States and internationally. The company offers JAKAFI, a drug for the treatment of myelofibrosis and polycythemia vera cancers; PEMAZYRE, a fibrobla...

Website: http://www.incyte.com

Founded: 2002

Full Time Employees: 1,456

Sector: Healthcare

Industry: Biotechnology

Pharmaceuticals

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Quarterly

Annual

Unit: USD	2026-03-31	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-09-30	2014-06-30	2014-03-31	2013-09-30	2013-06-30	2013-03-31	2012-09-30	2012-06-30	2012-03-31	2011-09-30	2011-06-30	2011-03-31	2010-09-30	2010-06-30	2010-03-31	2009-09-30	2009-06-30	2009-03-31	2008-09-30	2008-06-30	2008-03-31	2007-12-31	2007-09-30	2007-06-30	2007-03-31	2006-12-31	2006-09-30	2006-06-30	2006-03-31	2005-12-31	2005-09-30	2005-06-30	2005-03-31	2004-12-31	2004-09-30	2004-06-30	2004-03-31	2003-12-31	2003-09-30	2003-06-30	2003-03-31	2002-12-31	2002-09-30	2002-06-30	2002-03-31

revenues:
net sales	1,104,484,000
product royalty revenues	151,192,000	171,124,000	151,115,000	130,624,000	159,291,000	156,879,000	137,193,000	125,966,000	149,612,000	130,828,000	127,605,000	115,436,000	132,485,000	110,293,000	117,546,000	122,414,000	164,815,000	183,974,000	120,559,000	99,907,000	120,042,000	98,391,000	92,753,000	81,780,000	88,611,000	80,083,000	76,035,000	61,608,000	69,188,000	61,923,000	55,953,000	47,716,000	52,314,000	44,487,000	34,769,000	29,221,000	-77,375,289	29,626,000	25,958,000	21,903,000	23,646,000	18,138,000	17,364,000	15,673,000	12,093,000	12,340,000	9,826,000	8,184,000	5,800,000	5,909,000
milestone and contract revenues	17,000,000	45,000,000	5,000,000			18,000,000		25,000,000	2,000,000	5,000,000			30,000,000		130,000,000	5,000,000	50,000,000	35,000,000	10,000,000		110,000,000		95,000,000			17,500,000	20,000,000	40,000,000
total revenues	1,272,676,000	1,365,980,000	1,215,529,000	1,052,898,000	1,178,698,000	1,137,871,000	1,043,759,000	880,889,000	1,013,341,000	919,025,000	954,610,000	808,673,000	926,700,000	823,303,000	911,397,000	733,235,000	862,853,000	812,987,000	705,709,000	604,718,000	789,509,000	620,643,000	688,043,000	568,507,000	579,389,000	551,581,000	529,932,000	497,857,000	528,402,000	449,683,000	521,516,000	382,282,000	444,156,000	381,534,000	326,444,000	384,082,000	-778,115,281	269,469,000	246,288,000	263,464,000	243,881,000	187,611,000	162,984,000	159,275,000	198,147,000	99,582,000	89,792,000	85,123,000	101,675,000	71,077,000	60,492,000	86,542,000	36,179,000	16,782,000	16,811,000	31,973,000	16,872,000	49,847,000	17,288,000	939,000	789,000	671,000	1,061,000	614,000	1,307,000	6,172,000	6,690,000	10,576,000	7,422,000	7,056,000	7,268,000	6,855,000	6,465,000
yoy	7.97%	20.05%	16.46%	19.53%	16.32%	23.81%	9.34%	8.93%	9.35%	11.63%	4.74%	10.29%	7.40%	1.27%	29.15%	21.25%	9.29%	30.99%	2.57%	6.37%	36.27%	12.52%	29.84%	14.19%	9.65%	22.66%	1.61%	30.23%	18.97%	17.86%	59.76%	-0.47%	-157.08%	41.59%	32.55%	45.78%	-419.06%	43.63%	51.11%	65.41%	23.08%	88.40%	81.51%	87.11%	94.88%	40.10%	48.44%	-1.64%	181.03%	323.53%	259.84%	170.67%	114.43%	-66.33%	-2.76%	3305.01%	2038.40%	7328.76%	1529.41%	52.93%	-39.63%	-89.13%	-84.14%	-94.19%	-82.39%	-12.53%	-7.95%	54.28%	14.80%
qoq	-6.83%	12.38%	15.45%	-10.67%	3.59%	9.02%	18.49%	-13.07%	10.26%	-3.73%	18.05%	-12.74%	12.56%	-9.67%	24.30%	-15.02%	6.13%	15.20%	16.70%	-23.41%	27.21%	-9.80%	21.03%	-1.88%	5.04%	4.09%	6.44%	-5.78%	17.51%	-13.77%	36.42%	-13.93%	16.41%	16.88%	-15.01%	-149.36%	-388.76%	9.41%	-6.52%	8.03%	29.99%	15.11%	2.33%	-19.62%	98.98%	10.90%	5.49%	-16.28%	43.05%	17.50%	-30.10%	139.21%	115.58%	-0.17%	-47.42%	89.50%	-66.15%	188.33%	1741.11%	19.01%	17.59%	-36.76%	72.80%	-53.02%	-78.82%	-7.74%	-36.74%	42.50%	5.19%	-2.92%	6.02%	6.03%
costs, expenses and other:
cost of sales	104,523,000
research and development	515,903,000	506,584,000	494,917,000	437,279,000	466,034,000	573,174,000	1,138,380,000	429,260,000	444,494,000	375,709,000	400,750,000	406,641,000	501,360,000	384,007,000	347,196,000	353,373,000	472,827,000	334,945,000	343,511,000	306,896,000	405,945,000	438,109,000	286,601,000	1,085,287,000	312,867,000	281,336,000	289,363,000	270,545,000	304,238,000	292,527,000	298,089,000	303,103,000	446,938,000	269,612,000	201,839,000	407,972,000	-419,694,139	143,184,000	120,269,000	156,824,000	116,632,000	132,073,000	112,445,000	118,365,000	88,537,000	84,683,000	75,585,000	71,704,000	60,950,000	52,763,000	50,079,000	51,588,000	48,960,000	44,604,000	46,047,000	36,282,000	30,609,000	28,883,000	31,439,000	26,535,000	29,035,000	29,587,000	36,949,000	38,132,000	32,955,000	18,062,750	25,044,000	23,301,000	23,906,000	23,559,000	19,558,000	19,724,000	24,757,000	-71,580,382	27,356,000	26,556,000	17,764,000	17,892,000	18,629,000	25,565,000	26,184,000	27,570,000	28,619,000	29,870,000	30,186,000	33,612,000	47,406,000	37,717,000	33,743,000
selling, general and administrative	328,087,000	329,081,000	331,022,000	325,691,000	326,710,000	309,209,000	305,982,000	300,256,000	293,865,000	267,893,000	283,929,000	315,606,000	272,819,000	266,460,000	253,277,000	209,584,000	226,202,000	190,704,000	168,859,000	153,795,000	166,988,000	120,788,000	117,998,000	111,148,000	136,177,000	102,608,000	105,943,000	123,983,000	108,358,000	96,522,000	108,029,000	121,498,000	97,829,000	91,271,000	90,072,000	87,234,000	-206,862,749	75,776,000	66,792,000	64,596,000	52,467,000	47,599,000	51,679,000	44,871,000	39,446,000	40,899,000	36,974,000	26,447,000	23,249,000	22,261,000	20,520,000	19,719,000	21,396,000	14,282,000	11,858,000	10,825,000	8,458,000	7,485,000	5,794,000	4,841,000	4,086,000	4,821,000	4,005,000	4,103,000	4,354,000	2,703,500	3,587,000	3,535,000	3,692,000	3,277,000	3,454,000	3,421,000	3,876,000	-8,232,344	2,710,000	2,734,000	2,801,000	3,510,000	5,236,000	6,004,000	6,292,000	6,669,000	8,585,000	7,694,000	7,377,000	8,084,000	12,147,000	12,748,000	14,168,000
asset impairment and related disposal costs	23,214,000
loss on change in fair value of acquisition-related contingent consideration	-168,000	-12,204,000	22,761,000	11,572,000	-4,044,000	23,410,000	893,000	-456,000	15,058,000	-426,000	8,374,000	6,196,000	24,347,000	-21,893,000
total costs, expenses and other	971,559,000	922,462,000	685,215,000	847,730,000	877,185,000	991,786,000	1,521,889,000	788,991,000
income from operations	301,117,000	443,518,000	530,314,000	205,168,000	301,513,000	146,085,000	-478,130,000	91,898,000	187,270,000	214,705,000	193,780,000	24,770,000	70,093,000	138,376,000	254,431,000	116,540,000	110,734,000	235,410,000	140,836,000	98,797,000	164,229,000	5,326,000	230,773,000	-664,004,000	95,008,000	134,316,000	98,612,000	74,070,000	81,975,000	31,119,000	83,239,000	-67,110,000	-132,588,000	14,958,000	7,200,000	-133,304,000	-102,774,002	22,292,000	44,589,000	36,039,000	65,078,000	-101,000			69,943,000				17,319,000			15,219,000						13,624,000																			-17,993,000	-34,093,000	-20,340,000	-60,943,000	-33,477,000	-38,035,000	-30,170,000	-26,818,000	-54,273,000	-56,414,000	-37,464,000	-22,777,000	-18,897,000
yoy	-0.13%	203.60%	-210.91%	123.26%	61.00%	-31.96%	-346.74%	271.01%	167.17%	55.16%	-23.84%	-78.75%	-36.70%	-41.22%	80.66%	17.96%	-32.57%	4320.02%	-38.97%	-114.88%	72.86%	-96.03%	134.02%	-996.45%	15.90%	331.62%	18.47%	-210.37%	-161.83%	108.04%	1056.10%	-49.66%	29.01%	-32.90%	-83.85%	-469.89%	-257.92%	-22171.29%			-6.96%				303.85%																																-46.25%	-10.36%	-32.58%	127.25%	-38.32%	-32.58%	-19.47%	17.74%	187.20%
qoq	-32.11%	-16.37%	158.48%	-31.95%	106.40%	-130.55%	-620.28%	-50.93%	-12.78%	10.80%	682.32%	-64.66%	-49.35%	-45.61%	118.32%	5.24%	-52.96%	67.15%	42.55%	-39.84%	2983.53%	-97.69%	-134.75%	-798.89%	-29.27%	36.21%	33.13%	-9.64%	163.42%	-62.61%	-224.03%	-49.38%	-986.40%	107.75%	-105.40%	29.71%	-561.04%	-50.01%	23.72%	-44.62%	-64533.66%																																				-47.22%	67.62%	-66.62%	82.04%	-11.98%	26.07%	12.50%	-50.59%	-3.80%	50.58%	64.48%	20.53%
operating margin %	23.66%	32.47%	43.63%	19.49%	25.58%	12.84%	-45.81%	10.43%	18.48%	23.36%	20.30%	3.06%	7.56%	16.81%	27.92%	15.89%	12.83%	28.96%	19.96%	16.34%	20.80%	0.86%	33.54%	-116.80%	16.40%	24.35%	18.61%	14.88%	15.51%	6.92%	15.96%	-17.56%	-29.85%	3.92%	2.21%	-34.71%	13.21%	8.27%	18.10%	13.68%	26.68%	-0.05%	0%	0%	35.30%	0%	0%	0%	17.03%	0%	0%	17.59%	0%	0%	0%	0%	0%	27.33%	0%	0%	0%	0%	0%	0%	0%	0%	0%	0%	0%	0%	0%	0%	0%	NaN%	NaN%	NaN%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%
interest income	33,687,000	26,781,000	25,136,000	22,929,000
interest expense	-569,000	-592,000	-594,000	-660,000	-419,000	-774,000	-657,000	-430,000	-804,000	-623,000	-655,000	-469,000	-667,000	-641,000	-678,000	-680,000	-752,000	-439,000	-358,000	-359,000	-428,000	-544,000	-600,000	-602,000	-607,000	-597,000	-316,000	-335,000	-355,000	-405,000	-398,000	-385,000	-373,000	-204,000	-384,000	-5,939,000	29,236,255	-9,479,000	-9,662,000	-10,134,000	-10,213,000	-11,209,000																																			-4,317,000	-4,230,000	-4,623,000	-4,868,000	-3,520,000	-2,384,000	-2,299,000	-2,439,000	-2,439,000	-2,425,000	-2,450,000	-2,389,000	-2,538,000
gain on equity investments	6,591,000	8,558,000	-4,151,000	-1,343,000
other	2,774,000	4,043,000	7,307,000	8,096,000
income before provision for income taxes	343,600,000	482,308,000	558,012,000	234,190,000	313,724,000	156,524,000	-389,777,000	236,159,000	270,956,000	233,799,000	277,604,000	51,856,000	80,615,000	148,588,000	229,378,000	70,535,000	120,020,000	209,469,000	171,633,000	69,322,000	168,102,000	-3,508,000	307,264,000	-704,076,000	126,004,000	148,019,000	108,671,000	104,097,000	70,717,000	30,976,000	54,008,000	-40,354,000	-148,277,000	43,354,000	-9,384,000	-197,983,000	-97,851,596	38,302,000	35,210,000	24,447,000	55,688,000	-39,573,000	9,430,000
provision for income taxes	40,270,000	58,139,000	153,013,000	75,987,000	112,512,000	50,068,000	54,824,000	66,611,000	69,877,000	62,530,000	74,056,000	30,153,000	52,154,000	35,813,000	67,946,000	32,543,000	-443,831,000	27,730,000	22,177,000	15,787,000	18,252,000	11,695,000	16,966,000	16,566,000	14,999,000	19,748,000	3,353,000	1,785,000	1,654,000	1,800,000	1,614,000	786,000	1,352,000	7,300,000	3,100,000	-10,900,000	-2,606,818	1,425,000	785,000	400,000	512,000	9,000	136,000	367,000	72,000	70,000	49,000	49,000	71,000	43,000	26,000	67,000						331,000	327,000																			226,000		99,000	128,000	-214,000	190,000	241,000	260,000	217,000	300,000	300,000	303,000
net income	303,330,000	424,169,000	404,999,000	158,203,000	201,212,000	106,456,000	-444,601,000	169,548,000	201,079,000	171,269,000	203,548,000	21,703,000	28,461,000	112,775,000	161,432,000	37,992,000	563,851,000	181,739,000	149,456,000	53,535,000	149,850,000	-15,203,000	290,298,000	-720,642,000	111,005,000	128,271,000	105,318,000	102,312,000	69,063,000	29,176,000	52,394,000	-41,140,000	-149,629,000	36,054,000	-12,484,000	-187,083,000	-95,244,778	36,877,000	34,425,000	24,047,000	55,176,000	-39,582,000	9,294,000	-18,359,000	59,293,000	-36,873,000	-33,957,000	-22,037,000	-2,571,000		-21,710,000	4,037,000		-53,078,000	-51,870,000		-31,701,000	3,044,000								-16,270,000	-24,494,000										-20,131,000	-37,526,000	-25,976,000	-63,600,000	-37,715,000	-40,767,000	-43,012,000	-26,900,000	-55,784,000	-67,492,000	-38,411,000	-17,541,000	-13,441,000
yoy	50.75%	298.45%	-191.09%	-6.69%	0.07%	-37.84%	-318.43%	681.22%	606.51%	51.87%	26.09%	-42.87%	-94.95%	-37.95%	8.01%	-29.03%	276.28%	-1295.42%	-48.52%	-107.43%	34.99%	-111.85%	175.64%	-804.36%	60.73%	339.65%	101.01%	-348.69%	-146.16%	-19.08%	-519.69%	-78.01%	57.10%	-2.23%	-136.26%	-877.99%	-272.62%	-193.17%	270.40%	-230.98%	-6.94%	7.35%	-127.37%	-16.69%	-2406.22%		56.41%	-645.88%			-58.15%			-1843.69%																							-46.62%	-7.95%	-39.61%	136.43%	-32.39%	-39.60%	11.98%	53.35%	315.03%
qoq	-28.49%	4.73%	156.00%	-21.37%	89.01%	-123.94%	-362.23%	-15.68%	17.41%	-15.86%	837.88%	-23.74%	-74.76%	-30.14%	324.91%	-93.26%	210.25%	21.60%	179.17%	-64.27%	-1085.66%	-105.24%	-140.28%	-749.20%	-13.46%	21.79%	2.94%	48.14%	136.71%	-44.31%	-227.36%	-72.51%	-515.01%	-388.80%	-93.33%	96.42%	-358.28%	7.12%	43.16%	-56.42%	-239.40%	-525.89%	-150.62%	-130.96%	-260.80%	8.59%	54.09%	757.14%			-637.78%			2.33%			-1141.43%									-33.58%											-46.35%	44.46%	-59.16%	68.63%	-7.49%	-5.22%	59.90%	-51.78%	-17.35%	75.71%	118.98%	30.50%
net income margin %	23.83%	31.05%	33.32%	15.03%	17.07%	9.36%	-42.60%	19.25%	19.84%	18.64%	21.32%	2.68%	3.07%	13.70%	17.71%	5.18%	65.35%	22.35%	21.18%	8.85%	18.98%	-2.45%	42.19%	-126.76%	19.16%	23.26%	19.87%	20.55%	13.07%	6.49%	10.05%	-10.76%	-33.69%	9.45%	-3.82%	-48.71%	12.24%	13.69%	13.98%	9.13%	22.62%	-21.10%	5.70%	-11.53%	29.92%	-37.03%	-37.82%	-25.89%	-2.53%	0%	-35.89%	4.66%	0%	-316.28%	-308.55%	0%	-187.89%	6.11%	0%	0%	0%	0%	0%	0%	0%	-263.61%	-366.13%	0%	0%	0%	0%	0%	0%	NaN%	NaN%	NaN%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%
net income per share
basic	1.52	2.17	2.09	0.82	0.96	0.55	-2.04	0.76	0.9	0.76	0.91	0.1	0.12	0.51	0.73	0.17	2.55	0.82	0.68	0.24	0.69	-0.07	1.33	-3.33	0.51	0.6	0.49	0.48	0.33	0.14	0.25		-0.72	0.17	-0.06	-0.96	0.04	0.2	0.18	0.13	0.31	-0.22			0.35				-0.02			0.03			-0.41			0.03
diluted	1.47	2.11	2.04	0.8	0.95	0.54	-2.04	0.75	0.89	0.76	0.9	0.1	0.12	0.5	0.72	0.17	2.54	0.82	0.67	0.24	0.69	-0.07	1.32	-3.33	0.5	0.59	0.48	0.47	0.32	0.14	0.24		-0.72	0.17	-0.06	-0.96	0.05	0.19	0.18	0.12	0.3	-0.22			0.33				-0.02			0.03						0.02
shares used in computing net income per share:
basic	199,343	195,670	193,995	193,712	-4,653	192,629	218,175	224,484	200	224,078	223,248	222,960	203	222,415	221,660	221,326	185	220,845	220,083	219,801	389	218,784	217,549	216,721	285	215,199	214,620	214,065	211	212,627	212,210		2,181	206,796	205,141	195,260	241	188,029	187,682	187,184	2,223	181,387	178,676		168,592				142,284			129,224			125,330			121,630
diluted	206,830	201,429	198,744	198,197	-1,233	195,838	218,175	227,219	172	226,167	225,649	225,589	332	224,175	223,661	222,950	-39	222,248	222,250	221,867	389	218,784	220,434	216,721	264	217,791	217,483	217,061	119	215,964	215,103		2,181	212,610	205,141	195,260	371	194,265	193,015	192,625	9,924	181,387	186,493		189,046				142,284			137,969			125,330			128,291
product revenues		1,149,856,000	1,059,414,000	922,274,000	1,019,407,000	962,992,000	906,566,000	729,923,000	861,729,000	783,197,000	827,005,000	693,237,000	764,215,000	713,010,000	663,851,000	605,821,000	648,038,000	594,013,000	575,150,000	504,811,000	559,467,000	522,252,000	500,290,000	486,727,000	490,778,000	453,998,000	433,897,000	396,249,000	399,156,000	367,715,000	365,524,000	334,505,000	321,809,000	322,029,000	291,667,000	264,807,000	-631,123,596	236,623,000	212,116,000	183,267,000	182,021,000	161,259,000	142,406,000	115,330,000	97,837,000	84,025,000	69,651,000	60,201,000	54,099,000	48,289,000	43,695,000	29,727,000	19,279,000
cost of product revenues		99,001,000	78,766,000	73,188,000	88,485,000	85,993,000	76,634,000	60,956,000	69,751,000	60,091,000	68,326,000	56,822,000	59,163,000	54,584,000	50,636,000	42,614,000	43,874,000	39,869,000	38,028,000	29,220,000	36,323,000	34,322,000	33,364,000	27,319,000	32,215,000	30,040,000	29,406,000	22,588,000	26,366,000	24,795,000	24,856,000	18,106,000	22,359,000	22,036,000	20,260,000	14,824,000	-38,518,813	20,205,000	12,367,000	6,005,000	9,704,000	8,040,000	6,254,000	2,974,000	221,000	187,000	168,000	155,000	157,000	150,000	31,000	16,000	11,000
contract dispute settlement			-242,251,000
(profit) and loss sharing under collaboration agreements								-1,025,000			-549,000	-1,362,000
loss and (profit) sharing under collaboration agreements					-256,250				-214,500	1,053,000
interest income and other					29,677,000	24,195,000	49,769,000	44,744,000	50,436,000	46,371,000	42,668,000	32,873,000
realized and unrealized gain on equity investments					-10,181,000	-12,982,000	39,241,000
unrealized gain on long term investments								99,947,000	34,054,000	-26,654,000	41,811,000				-24,897,000		4,322,000	-27,450,000	26,765,000		-509,000	-13,207,000	72,274,000	-48,132,000	15,755,000	2,339,000	-4,625,000	20,989,000	-5,477,750	-9,949,000		22,679,000	-585,750	23,045,000
costs and expenses:
total costs and expenses									826,071,000	704,320,000	760,830,000	783,903,000	856,607,000	684,927,000	656,966,000	616,695,000	752,119,000	577,577,000	564,873,000	505,921,000	625,280,000	615,317,000	457,270,000	1,232,511,000	484,381,000	417,265,000	431,320,000	423,787,000	446,427,000	418,564,000	438,277,000	449,392,000	576,744,000	366,576,000	319,244,000	517,386,000	-675,341,279	247,177,000	201,699,000	227,425,000	178,803,000	187,712,000	170,378,000	166,210,000	128,204,000	125,769,000	112,727,000	98,306,000	84,356,000	75,174,000	70,630,000	71,323,000	70,367,000	58,886,000	57,925,000	47,798,000	38,928,000	36,223,000	37,118,000	32,502,000	33,527,000	34,917,000	40,854,000	41,317,000	37,432,000	20,633,250	28,065,000	26,763,000	27,705,000	26,615,000	23,025,000	26,035,000	28,834,000	-80,899,370	30,365,000	29,736,000	20,908,000	33,041,000	23,733,000	66,106,000	40,118,000	48,333,000	43,419,000	37,854,000	66,782,000				47,911,000
unrealized loss on long term investments												-5,318,000	-18,035,500	-660,000		-46,585,000				-27,709,000											-34,641,000				-19,574,000	-5,814,000
collaboration loss sharing													2,263,750	1,769,000	2,544,000	4,742,000	7,543,000	9,149,000	9,843,000	10,484,000	12,429,000	14,989,000	13,253,000	2,130,000
other income													26,637,000	11,513,000	522,000	1,260,000	5,716,000	1,948,000	4,390,000	-1,407,000	4,810,000	4,917,000	4,817,000	8,662,000	15,848,000	11,961,000	15,000,000	9,373,000	11,279,000	10,211,000	5,808,000	4,462,000
change in fair value of acquisition-related contingent consideration															3,313,000	6,382,000	1,673,000	2,910,000	4,632,000	5,526,000	3,595,000	7,109,000	6,054,000	6,627,000	3,122,000	3,281,000	6,608,000	6,671,000	7,465,000	4,720,000	7,303,000	6,685,000	9,618,000	-16,343,000	7,073,000	7,356,000	-10,265,578	8,012,000	2,271,000

other revenues																													58,000	45,000	39,000	61,000	33,000	18,000	8,000	54,000	-85,908	6,000		80,000				58,000	3,000	3,000	101,000	1,000	39,000	142,000	60,000
milestone revenues																													30,000,000	20,000,000	100,000,000
expense related to senior note conversions																																			-751,000	-54,130,000
basic and diluted net loss per share																																-0.19												-0.11																		-0.41			-0.47			-0.22	-0.26															-0.37	-0.81	-0.258	-0.57	-0.26	-0.2
shares used in computing basic and diluted net loss per share																																211,681												172,070			165,357			134,345	130,851		127,203	126,260		123,467	122,189		119,727	98,030	97,643	97,340	92,385	84,871	84,602	21,027.75	84,213	84,136	83,985	44	83,852	83,786	83,627	20,803.25	83,414	83,303	83,049	1,589	73,323	72,929	72,643	17,755.5	72,185	71,895	68,986	16,837	67,740	67,440	66,864
contract revenues																																	26,250,000	15,000,000		90,000,000	-69,530,488	3,214,000	8,214,000	58,214,000	38,214,000	8,214,000	3,214,000	28,214,000	88,214,000	3,214,000	10,214,000	16,737,000	41,737,000	16,737,000	16,737,000	56,737,000	16,737,000	16,737,000	16,737,000	31,738,000	16,737,000	49,737,000	16,737,000				15,000	57,000	587,000	5,229,000	5,909,000	8,933,000	6,074,000	6,157,000	6,249,000	6,292,000	5,529,000
interest and other income																																	6,616,000	5,555,000	4,125,000	1,204,000	-3,813,588	1,188,000	1,137,000	1,492,000	1,289,000	3,026,000	1,144,000	1,630,000	885,000	790,000	735,000	385,000	245,000	199,000	27,000	315,000		45,000	132,000	72,000		142,000				548,000	1,253,000	1,353,000	2,141,000	2,665,750	2,883,000	3,713,000	4,066,000	5,209,000	3,996,000	2,596,000	8,886,000			5,420,000	2,152,000	2,160,000	-571,000	2,387,000	-413,000	-450,000	-11,259,000	2,490,000	1,233,000	-6,972,000	1,648,000	6,601,000	8,157,000
unrealized gain on long term investment																																					-20,500,261	24,301,000	-854,000				27,174,000
unrealized loss on long term investment																																								-2,950,000	-466,000	-31,289,000
debt exchange expense on senior note conversions
net income (loss) per share:
basic																																											0.05
diluted																																											0.05
income before income taxes																																													59,365,000	-36,803,000		-21,988,000	-2,500,000		-21,684,000	4,104,000						3,375,000																				-31,766,000	-25,976,000	-63,501,000	-37,587,000	-31,251,250	-42,822,000	-26,659,000	-55,524,000
net loss per basic and diluted share:																																														-220
shares used in computing basic and diluted net loss per share:																																														167,914		155,067
basic and diluted net loss per share:																																															-0.21	-0.14		-0.12	-0.17		-0.36	-0.42		-0.21			-0.3	-0.44	-0.41		-0.48	-0.54		-0.193	-0.29											-0.435	-0.35	-0.87	-0.52	-0.443	-0.6
debt exchange expense
shares used in computing basic and diluted net income per share
basic	199,343	195,670	193,995	193,712	-4,653	192,629	218,175	224,484	200	224,078	223,248	222,960	203	222,415	221,660	221,326	185	220,845	220,083	219,801	389	218,784	217,549	216,721	285	215,199	214,620	214,065	211	212,627	212,210		2,181	206,796	205,141	195,260	241	188,029	187,682	187,184	2,223	181,387	178,676		168,592				142,284			129,224			125,330			121,630
diluted	206,830	201,429	198,744	198,197	-1,233	195,838	218,175	227,219	172	226,167	225,649	225,589	332	224,175	223,661	222,950	-39	222,248	222,250	221,867	389	218,784	220,434	216,721	264	217,791	217,483	217,061	119	215,964	215,103		2,181	212,610	205,141	195,260	371	194,265	193,015	192,625	9,924	181,387	186,493		189,046				142,284			137,969			125,330			128,291
other expenses																																																							20,000	691,000				1,126,000	406,000	509,000			123,000				107,000	-221,000	13,000	2,890,000	201,000	-1,086,644	299,000	446,000	343,000	11,639,000	-132,000	34,537,000	7,642,000	14,508,000	-35,000	290,000	1,103,000	35,668,000	292,000	1,371,000
license and royalty revenues																																																				78,000	163,000	45,000	74,000	235,000	135,000	110,000	551,000	939,000	789,000	671,000	1,046,000	557,000	720,000	943,000	781,000	1,643,000	1,348,000	899,000	1,019,000	563,000	936,000
interest and other income																																																					52,000
loss on debt redemption
interest and other income (expense)																																																									212,000		195,000	105,000														2,557,000	2,656,000
basic and diluted loss per share:																																																									-0.26
loss on debt repurchases
gain on repurchase of convertible subordinated notes																																																																										-505,494	85,000				-226,000				706,000					1,937,000
loss on certain derivative financial instruments																																																																													-126,000
loss from continuing operations before income taxes																																																																													-20,284,000
loss from continuing operations																																																																						-13,415,750	-15,838,000	-20,520,000		-18,911,500	-30,207,000	-25,154,000	-20,284,000
income from discontinued operation, net of tax																																																																										39,750		9,000	153,000
continuing operations																																																																						-0.25	-0.19	-0.24	-0.21	-0.33	-0.36	-0.3	-0.24
discontinued operations
gain on certain derivative financial instruments																																																																									36,000			39,000		16,000	-216,000	-77,000	-177,000	-112,000	200,000	108,000	-45,000	-1,464,000	155,000	-613,000	140,000
revenues																																																																										-6,810,154	1,228,000	2,676,000	2,915,000	-1,052,000	3,393,000	5,163,000	6,641,000	10,298,000	13,249,000	11,036,000	12,509,000	21,149,000	22,390,000	29,059,000	29,014,000
income from discontinued operations, net of tax
provisionfor income taxes
gain on debt repurchase																																																																												421,000
discontinued operation
purchased in-process research and development																																																																																		-414,000	6,250,000		28,116,000
loss on sale of assets																																																																																						199,000	9,000
operating expenses:
total operating expenses																																																																																						39,900,250	59,854,000	51,836,000
loss before income taxes and accounting change																																																																																						-17,122,500	-38,111,000	-17,241,000
loss before accounting change																																																																																						-17,348,250	-38,411,000	-17,541,000
cumulative effect of accounting change
per share data:
loss before income taxes, extraordinary item and accounting change																																																																																									-13,138,000
loss before extraordinary item and accounting change																																																																																									-13,441,000
extraordinary gain

Balance Sheets:

Quarterly

Annual

Unit: USD	2026-03-31	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-09-30	2014-06-30	2014-03-31	2013-09-30	2013-06-30	2013-03-31	2012-09-30	2012-06-30	2012-03-31	2011-09-30	2011-06-30	2011-03-31	2010-09-30	2010-06-30	2010-03-31	2009-09-30	2009-06-30	2009-03-31	2008-09-30	2008-06-30	2008-03-31	2007-12-31	2007-09-30	2007-06-30	2007-03-31	2006-12-31	2006-09-30	2006-06-30	2006-03-31	2005-12-31	2005-09-30	2005-06-30	2005-03-31	2004-12-31	2004-09-30	2004-06-30	2004-03-31	2003-12-31	2003-09-30	2003-06-30	2003-03-31	2002-12-31	2002-09-30	2002-06-30	2002-03-31

assets
current assets:
cash and cash equivalents	3,461,114,000	2,455,006,000	1,954,969,000	1,941,722,000	1,687,829,000	1,304,109,000	987,293,000	3,346,204,000	3,213,376,000	3,227,230,000	3,131,123,000	2,821,051,000	2,951,422,000	2,690,622,000	2,435,381,000	2,256,759,000	2,057,440,000	1,999,021,000	1,797,582,000	1,669,968,000	1,513,008,000	1,497,775,000	1,326,730,000	1,043,241,000	1,832,684,000	1,702,023,000	1,416,224,000	1,299,704,000	1,163,980,000	1,112,179,000	928,517,000	894,427,000	899,509,000	1,128,046,000	451,754,000	361,823,000	652,343,000	580,099,000	487,654,000	657,615,000	521,439,000	445,801,000	439,681,000	421,822,000	382,004,000	406,264,000	436,585,000	272,122,000	258,202,000	265,814,000	239,083,000	257,563,000	231,855,000	312,328,000	359,074,000	377,843,000	388,804,000	414,088,000	404,746,000	367,478,000	114,289,000	139,098,000	207,597,000	134,712,000	162,741,000		95,629,000	33,935,000	20,298,000	18,861,000	115,921,000	35,938,000	48,804,000	11,494,000	49,197,000	37,177,000	104,836,000	132,180,000	78,724,000	152,933,000	135,847,000	29,698,000	14,307,000	22,015,000	10,637,000	22,928,000	15,736,000	44,193,000	99,156,000
marketable securities—available-for-sale	554,711,000	474,814,000	466,769,000	466,936,000	470,263,000	467,235,000	462,207,000	504,484,000	442,667,000	289,223,000	292,243,000	291,661,000	287,543,000	286,500,000	287,044,000	287,401,000	290,752,000	285,054,000	283,385,000	292,425,000	288,369,000	237,025,000	262,756,000	259,351,000	284,870,000	284,195,000	279,631,000	281,320,000	274,343,000	263,134,000	269,865,000	276,632,000	270,136,000	153,343,000	156,852,000	150,132,000	156,203,000	136,486,000	141,537,000	153,054,000	186,344,000	189,244,000	187,788,000	163,602,000	150,355,000	102,489,000	82,646,000	19,052,000	19,251,000	4,365,000	4,516,000	4,244,000	4,556,000	4,647,000	5,036,000	5,783,000	6,781,000	8,102,000	17,494,000	20,767,000	26,186,000	18,591,000	42,264,000	51,309,000	56,372,000		169,315,000	247,533,000	273,480,000	299,712,000	310,380,000	253,808,000	272,695,000	333,477,000	314,841,000	364,272,000	343,858,000	337,584,000	333,838,000	320,622,000	364,860,000	264,109,000	300,791,000	338,624,000	365,547,000	406,090,000	437,093,000	431,958,000	392,554,000
accounts receivable	1,051,499,000	895,890,000	842,892,000	823,134,000	853,154,000	758,450,000	739,050,000	745,526,000	743,557,000	657,263,000	637,994,000	623,788,000	644,879,000	618,188,000	682,968,000	562,344,000	616,300,000	516,689,000	438,170,000	397,357,000	481,994,000	356,182,000	420,250,000	351,522,000	308,809,000	276,116,000	302,680,000	244,081,000	307,598,000	247,736,000	316,310,000	220,190,000	266,299,000	198,345,000	169,516,000	244,975,000	148,758,000	131,523,000	129,486,000	101,280,000	114,450,000	86,966,000	75,122,000	69,604,000	109,599,000	47,205,000	46,394,000	33,197,000	27,522,000	28,041,000	16,540,000	13,841,000	13,010,000	2,462,000	2,376,000	16,579,000	4,735,000	6,360,000	5,253,000	862,000	807,000	739,000	879,000	787,000	840,000		1,276,000	1,267,000	1,440,000	2,073,000	1,390,000	1,346,000	1,584,000	1,423,000	1,045,000	931,000	2,547,000	2,143,000	2,679,000	3,336,000	3,909,000	5,733,000	10,179,000	7,515,000	8,024,000	8,485,000	14,780,000	25,129,000	27,691,000
inventory	115,624,000	83,447,000	83,423,000	63,975,000	58,872,000	70,442,000	100,704,000	63,642,000	62,972,000	57,200,000	35,937,000	40,876,000	41,995,000	45,869,000	54,502,000	35,457,000	27,904,000	21,303,000	16,675,000	16,700,000	16,425,000	17,012,000	16,335,000	13,977,000	11,400,000	7,365,000	6,527,000	7,129,000	6,967,000	5,993,000	5,869,000	4,632,000	6,482,000	3,261,000	2,930,000	3,961,000	4,106,000	4,078,000	6,124,000	1,309,000	1,783,000	2,428,000	1,897,000	2,414,000	402,000	269,000	347,000	359,000	133,000	189,000	190,000	188,000	3,513,000
prepaid expenses and other current assets	301,312,000	368,732,000	295,648,000	211,654,000	168,912,000	205,128,000	207,956,000	189,235,000	182,830,000	171,749,000	167,136,000	194,257,000	167,011,000	179,932,000	165,950,000	146,130,000	126,278,000	101,730,000	84,248,000	73,519,000	60,098,000	51,431,000	51,554,000	48,078,000	43,725,000	49,896,000	53,563,000	72,266,000	79,366,000	71,317,000	77,523,000	73,674,000	62,428,000	58,327,000	63,751,000	58,284,000	32,752,000	34,457,000	27,313,000	21,806,000	17,843,000	23,246,000	20,260,000	28,178,000	18,979,000	19,268,000	13,681,000	9,013,000	8,261,000	10,704,000	8,899,000	8,823,000	7,446,000	7,984,000	6,447,000	6,769,000	3,232,000	3,763,000	4,269,000	4,006,000	5,436,000	6,937,000	6,284,000	7,247,000	7,642,000		4,634,000	5,577,000	5,204,000	7,115,000	4,310,000	5,075,000	6,096,000	7,582,000	5,738,000	5,478,000	6,251,000	7,142,000	5,602,000	6,504,000	9,503,000	11,387,000	12,557,000	10,399,000	17,698,000	21,268,000	21,700,000	26,240,000	28,040,000
total current assets	5,484,260,000	4,277,889,000	3,643,701,000	3,507,421,000	3,239,030,000	2,808,708,000	2,567,085,000	4,849,091,000	4,645,402,000	4,402,665,000	4,264,433,000	3,971,633,000	4,092,850,000	3,821,111,000	3,625,845,000	3,288,091,000	3,118,674,000	2,923,797,000	2,620,060,000	2,449,969,000	2,359,894,000	2,159,425,000	2,077,625,000	1,716,169,000	2,481,488,000	2,319,595,000	2,058,625,000	1,904,500,000	1,832,254,000	1,700,359,000	1,598,084,000	1,469,555,000	1,504,854,000	1,541,322,000	844,803,000	819,175,000	994,178,000	886,660,000	792,130,000	935,581,000	842,375,000	757,914,000	732,990,000	692,145,000	662,614,000	577,145,000	581,170,000	333,743,000	313,369,000	309,113,000	278,728,000	294,158,000	276,162,000	346,418,000	391,923,000	425,968,000	422,545,000	451,293,000	450,807,000	402,657,000	146,718,000	165,365,000	257,024,000	194,055,000	227,595,000		270,854,000	288,312,000	300,422,000	327,761,000	432,001,000	296,167,000	329,179,000	353,976,000	370,821,000	407,858,000	457,492,000	481,313,000	420,843,000	483,395,000	514,119,000	310,927,000	337,834,000	378,553,000	401,906,000	458,771,000	489,309,000	527,520,000	547,441,000
restricted cash	1,836,000	1,843,000	1,844,000	1,665,000	1,622,000	1,737,000	1,631,000	1,627,000	1,845,000	1,717,000	1,719,000	1,717,000	1,698,000																																											18,994,000	18,993,000	18,980,000	19,045,000	9,544,000
long term equity investments	54,582,000	21,870,000	13,313,000	17,463,000	18,814,000	27,566,000	29,668,000
property and equipment	720,169,000	798,634,000	798,543,000	765,359,000	763,411,000	773,102,000	762,009,000	719,999,000	751,513,000	733,046,000	749,352,000	741,701,000	739,310,000	715,733,000	721,328,000	729,217,000	723,920,000	686,718,000	661,360,000	594,670,000	559,625,000	498,335,000	453,777,000	410,034,000	377,567,000	347,250,000	339,122,000	338,331,000	319,751,000	300,767,000	267,586,000	264,610,000	259,763,000	246,825,000	218,878,000	193,211,000	167,679,000	151,942,000	138,513,000	92,622,000	86,006,000	83,186,000	81,602,000	80,667,000	75,258,000	55,607,000	38,654,000	6,201,000	6,236,000	6,485,000	6,169,000	6,515,000	6,232,000	6,077,000	5,500,000	4,934,000	2,385,000	2,159,000	1,808,000	1,981,000	2,189,000	2,495,000	2,825,000	3,110,000	3,501,000		3,874,000	4,539,000	5,197,000	5,890,000	5,741,000	6,253,000	6,837,000	7,667,000	8,119,000	8,883,000	9,011,000	9,959,000	10,511,000	11,535,000	22,846,000	27,337,000	30,786,000	32,021,000	33,789,000	31,787,000	44,422,000	45,264,000	45,308,000
finance lease right-of-use assets	26,669,000	28,155,000	29,001,000	29,892,000	30,803,000	25,072,000	25,535,000	25,533,000	25,535,000	24,880,000	25,631,000	25,849,000	26,298,000	26,679,000	27,349,000	27,392,000	27,548,000	27,133,000	27,683,000	27,987,000	28,451,000	29,123,000	28,133,000	28,622,000	29,058,000	29,690,000
other intangible assets	110,164,000	119,421,000	126,419,000	107,611,000	113,803,000	119,994,000	113,536,000	117,841,000	123,545,000	129,249,000	134,954,000	140,658,000	129,219,000	134,603,000	139,987,000	145,371,000	150,755,000	156,139,000	161,523,000	166,907,000	172,291,000	177,675,000	183,060,000	188,444,000	193,828,000	199,212,000	204,596,000	209,980,000	215,364,000	220,748,000	226,132,000	231,517,000	236,901,000	242,285,000	247,669,000	253,053,000	258,437,000	263,821,000	269,205,000
goodwill	133,000,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,593,000	155,702,000	155,725,000
deferred income tax asset	452,520,000	528,138,000	652,280,000	768,899,000	762,071,000	762,310,000	729,561,000	666,566,000	631,886,000	564,385,000	532,507,000	494,751,000	457,941,000	426,840,000	434,867,000	465,369,000	467,538,000
other assets	24,492,000	32,303,000	32,552,000	30,151,000	10,848,000	40,378,000	21,917,000	47,400,000	52,107,000	80,955,000	31,706,000	20,720,000	25,435,000	23,666,000	23,012,000	31,423,000	37,304,000	24,788,000	20,449,000	38,814,000	41,458,000	53,109,000	53,265,000	61,779,000	49,431,000	38,628,000	36,606,000	20,698,000	19,157,000	14,665,000	10,731,000	9,881,000	2,224,000	7,033,000	3,225,000	543,000	2,644,000	2,564,000	2,496,000	12,298,000	12,279,000	19,169,000	15,938,000	19,087,000	15,739,000	16,514,000	17,125,000							8,744,000	9,269,000		11,335,000	11,962,000	12,587,000
total assets	7,339,113,000	6,330,356,000	5,821,354,000	5,749,365,000	5,444,322,000	5,012,434,000	4,661,803,000	7,135,605,000	6,782,107,000	6,388,239,000	6,208,259,000	5,797,623,000	5,840,984,000	5,510,214,000	5,319,035,000	5,054,221,000	4,933,352,000	4,198,831,000	3,904,623,000	3,661,436,000	3,560,918,000	3,307,430,000	3,212,321,000	2,752,422,000	3,426,750,000	3,214,818,000	2,947,633,000	2,754,161,000	2,645,762,000	2,519,947,000	2,397,157,000	2,306,012,000	2,302,582,000	2,374,301,000	1,639,443,000	1,607,347,000	1,638,597,000	1,544,195,000	1,417,975,000	1,103,942,000	1,007,440,000	931,932,000	930,337,000	862,624,000	785,265,000	679,107,000	666,826,000	357,400,000	334,219,000	330,282,000	296,535,000	311,971,000	293,593,000	371,224,000	416,663,000	459,606,000	464,640,000	493,681,000	502,663,000	472,816,000	159,016,000	189,635,000	264,718,000	204,735,000	237,011,000		282,683,000	308,798,000	324,933,000	353,603,000	464,886,000	375,112,000	398,756,000	374,108,000	398,109,000	436,647,000	487,458,000	516,919,000	470,504,000	538,118,000	582,468,000	379,545,000	415,437,000	470,475,000	496,878,000	552,139,000	603,054,000	645,736,000	666,847,000
liabilities and stockholders’ equity
current liabilities:
accounts payable	228,624,000	171,925,000	241,094,000	195,537,000	197,465,000	178,710,000	148,174,000	164,238,000	109,601,000	139,411,000	155,538,000	55,633,000	277,546,000	163,175,000	194,770,000	152,547,000	172,110,000	114,509,000	122,100,000	85,058,000	98,767,000	122,512,000	90,909,000	60,937,000	83,647,000	95,376,000	66,184,000	70,363,000	103,827,000	95,478,000	75,559,000	74,115,000	67,671,000	69,933,000	69,093,000	86,327,000	75,599,000	57,524,000	40,724,000	31,899,000	30,085,000	27,366,000	29,162,000	26,586,000	26,605,000	27,251,000	17,950,000	18,212,000	13,471,000	15,515,000	12,764,000	11,102,000	13,174,000	11,038,000	8,788,000	7,791,000	7,750,000	9,158,000	13,304,000	14,176,000	15,840,000	15,084,000	13,465,000	13,481,000	13,228,000		6,421,000	4,959,000	4,511,000	5,916,000	3,704,000	5,377,000	5,909,000	3,573,000	4,372,000	4,183,000	2,322,000	2,321,000	2,950,000	5,010,000	5,490,000	6,450,000	7,157,000	5,416,000	7,466,000	9,073,000	7,216,000	8,447,000	6,485,000
accrued compensation	124,920,000	168,250,000	129,114,000	102,820,000	188,677,000	150,722,000	113,536,000	89,109,000	153,348,000	124,783,000	111,708,000	84,717,000	138,761,000	106,309,000	93,145,000	83,657,000	108,962,000	105,705,000	82,762,000	75,718,000	113,340,000	96,391,000	67,396,000	57,779,000	90,706,000	80,638,000	53,697,000	48,522,000	60,176,000	58,027,000	41,704,000	51,349,000	74,550,000	61,274,000	50,902,000	54,622,000	50,904,000	47,414,000	31,545,000	23,197,000	38,117,000	30,070,000	25,794,000	24,324,000	26,481,000	19,683,000	14,691,000	17,957,000	14,327,000	11,836,000	15,839,000	13,122,000	11,981,000	13,608,000	10,099,000	9,085,000	10,920,000	8,019,000	7,842,000	9,133,000	6,487,000	6,024,000	8,572,000	5,954,000	5,510,000		7,027,000	4,909,000	4,333,000	6,879,000	6,132,000	4,280,000	4,089,000	7,590,000	6,210,000	5,111,000	4,635,000	7,876,000	6,458,000	5,856,000	7,340,000	12,402,000	12,559,000	11,156,000	9,338,000	14,319,000	13,095,000	14,852,000	13,547,000
accrued and other current liabilities	1,092,308,000	948,439,000	857,094,000	1,375,738,000	1,212,048,000	1,127,951,000	1,034,316,000	1,102,268,000	935,569,000	820,607,000	810,852,000	825,443,000	701,053,000	699,814,000	598,808,000	609,290,000	533,595,000	481,879,000	413,067,000	420,882,000	378,404,000	334,315,000	340,890,000	330,034,000	285,950,000	249,721,000	210,474,000	211,302,000	229,401,000	231,571,000	213,888,000	219,873,000	198,901,000	164,298,000	150,353,000	142,104,000	126,697,000	112,600,000	102,184,000	133,641,000	86,531,000	82,209,000	80,437,000	70,048,000	54,236,000	50,878,000	56,954,000	41,739,000	33,087,000	31,878,000	22,749,000	25,108,000	25,115,000	19,838,000	20,054,000	16,828,000	20,708,000	17,740,000	14,537,000	13,219,000	11,960,000	14,015,000	12,241,000	12,177,000	8,722,000		7,199,000	6,273,000	6,354,000	4,024,000	5,255,000	5,717,000	7,800,000	5,124,000	8,764,000	5,878,000	4,701,000	4,838,000	6,646,000	5,181,000	3,264,000	3,296,000	6,840,000		6,216,000	6,214,000	16,480,000		14,226,000
finance lease liabilities	4,413,000	4,491,000	4,475,000	4,478,000	4,419,000	3,932,000	3,874,000	3,678,000	3,439,000	3,064,000	3,166,000	3,149,000	3,179,000	3,112,000	3,036,000	2,796,000	2,635,000	2,400,000	2,408,000	2,317,000	2,284,000	1,978,000	1,189,000	910,000	664,000	763,000	791,000
acquisition-related contingent consideration	39,384,000	45,624,000	46,842,000	41,717,000	39,238,000	40,335,000	37,155,000	37,160,000	38,422,000	36,815,000	37,509,000	37,169,000	36,538,000	34,186,000	36,915,000	37,873,000	37,006,000	38,219,000	39,987,000	39,906,000	38,400,000	39,050,000	37,512,000	35,139,000	34,044,000	35,096,000	35,929,000	34,239,000	31,844,000	29,665,000	29,501,000	28,175,000	26,848,000	24,330,000	22,779,000	21,528,000	19,539,000	17,854,000	17,688,000
total current liabilities	1,489,649,000	1,338,729,000	1,278,619,000	1,720,290,000	1,641,847,000	1,501,650,000	1,337,055,000	1,396,453,000	1,240,379,000	1,124,680,000	1,118,773,000	1,006,111,000	1,157,077,000	1,006,596,000	926,674,000	886,163,000	854,308,000	742,712,000	660,324,000	623,881,000	631,195,000	606,202,000	556,513,000	503,412,000	513,340,000	461,683,000	367,105,000	364,515,000	425,277,000	422,489,000	368,239,000	381,072,000	375,396,000	319,935,000	293,161,000	304,716,000	273,501,000	240,545,000	198,986,000	200,319,000	168,007,000	155,823,000	192,472,000	225,595,000	124,660,000	112,547,000	106,944,000	109,498,000	102,958,000	121,283,000	137,641,000	139,731,000	142,299,000	120,957,000	110,667,000	110,182,000	117,522,000	110,944,000	117,944,000	44,276,000	45,621,000	42,098,000	40,820,000	41,651,000	34,304,000		33,214,000	38,192,000	39,650,000	49,340,000	136,793,000	140,951,000	140,342,000	27,857,000	27,284,000	27,033,000	21,640,000	31,481,000	60,898,000	67,908,000	46,968,000	57,426,000	53,482,000	61,296,000	60,939,000	77,693,000	60,429,000	69,214,000	66,299,000
other liabilities	126,587,000	171,176,000	179,914,000	175,586,000	167,543,000	144,676,000	142,099,000	151,107,000	149,151,000	133,068,000	139,812,000	118,414,000	99,243,000	74,677,000	76,058,000	69,474,000	70,414,000	62,305,000	57,587,000	54,463,000	58,282,000	44,597,000	42,799,000	39,469,000	40,130,000	33,892,000	33,761,000	33,671,000	21,927,000	21,000,000	20,480,000	21,260,000	19,797,000	13,235,000	12,798,000	12,621,000	12,687,000	10,084,000	10,123,000	48,233,000	48,385,000	50,863,000	51,858,000	52,910,000	52,382,000	44,403,000	34,036,000	3,392,000	3,433,000											2,372,000	3,600,000	5,614,000	7,573,000	9,000,000	10,858,000		13,439,000	14,908,000	16,561,000	17,720,000	19,263,000	20,431,000	22,237,000	23,786,000	25,391,000	26,357,000	27,264,000	28,155,000
total liabilities	1,716,266,000	1,679,162,000	1,650,451,000	2,081,802,000	1,996,694,000	1,841,214,000	1,664,744,000	1,741,334,000	1,592,270,000	1,456,792,000	1,467,567,000	1,335,055,000	1,470,865,000	1,283,563,000	1,233,974,000	1,191,149,000	1,163,348,000	1,050,174,000	968,762,000	933,592,000	949,650,000	916,597,000	867,717,000	814,701,000	828,344,000	792,291,000	700,442,000	668,594,000	719,795,000	717,048,000	664,234,000	677,968,000	671,953,000	616,551,000	612,608,000	641,413,000	1,219,130,000	1,174,209,000	1,120,912,000	876,194,000	836,285,000	843,195,000	875,163,000	904,037,000	874,856,000	850,105,000	829,248,000	328,609,000	362,005,000	493,808,000	516,485,000	529,159,000	542,450,000	552,244,000	552,947,000	563,584,000	593,548,000	598,464,000	617,076,000	672,172,000	450,446,000	446,386,000	442,095,000	441,930,000	434,059,000		424,156,000	428,433,000	429,410,000	438,511,000	531,036,000	429,837,000	436,527,000	393,505,000	394,594,000	402,896,000	427,590,000	438,402,000	439,744,000	485,486,000	464,650,000	225,212,000	221,372,000	233,119,000	232,869,000	249,729,000	232,572,000	241,464,000	245,436,000
commitments and contingencies
stockholders’ equity:
preferred stock, 0.001 par value...
common stock, 0.001 par value...	200,000	196,000	194,000	193,000	193,000	192,000	191,000	224,000	224,000	224,000	223,000	223,000	223,000	222,000	222,000	221,000	221,000	221,000	220,000	220,000	219,000	219,000	218,000	217,000	216,000	215,000	215,000	214,000	213,000	213,000	212,000	212,000	211,000	211,000	205,000	205,000	189,000	188,000	188,000	187,000	187,000	186,000	180,000	173,000	169,000	168,000	167,000	161,000	153,000	136,000	131,000	130,000	128,000	126,000	126,000	124,000	122,000	122,000	121,000	119,000	98,000	97,000	97,000	85,000	85,000		84,000	84,000	84,000	84,000	84,000	84,000	84,000	84,000	83,000	83,000	83,000	83,000				73,000				67,000
additional paid-in capital	5,083,234,000	4,721,953,000	4,666,949,000	4,588,286,000	4,533,437,000	4,429,466,000	4,382,734,000	5,070,286,000	5,016,122,000	4,949,023,000	4,925,626,000	4,856,914,000	4,792,041,000	4,721,166,000	4,688,985,000	4,625,780,000	4,567,111,000	4,508,807,000	4,477,378,000	4,420,902,000	4,352,864,000	4,276,667,000	4,217,911,000	4,102,011,000	4,044,490,000	3,972,689,000	3,925,975,000	3,869,952,000	3,813,678,000	3,759,030,000	3,718,518,000	3,666,346,000	3,627,433,000	3,585,403,000	2,892,092,000	2,824,298,000	2,096,929,000	2,053,046,000	2,016,728,000	1,982,104,000	1,950,764,000	1,922,989,000	1,847,626,000	1,760,033,000	1,656,901,000	1,634,621,000	1,606,365,000	1,720,788,000	1,642,198,000	1,503,898,000	1,450,439,000	1,431,921,000	1,404,076,000	1,371,524,000	1,363,052,000	1,343,351,000	1,324,611,000	1,317,169,000	1,311,181,000	1,102,765,000	967,964,000	964,574,000	956,798,000	850,692,000	845,184,000		837,392,000	834,686,000	831,242,000	828,936,000	826,255,000	824,173,000	821,204,000	818,638,000	818,103,000	818,016,000	817,062,000	817,150,000	730,934,000	729,797,000	727,771,000	726,962,000	726,113,000	726,672,000	725,563,000	708,163,000	712,720,000	712,098,000	710,306,000
accumulated other comprehensive income	22,314,000	14,555,000	13,439,000		-13,121,000	15,655,000	-5,420,000	-6,172,000	13,106,000	22,894,000	26,806,000	20,942,000	15,069,000																					12,512,000	10,968,000	5,377,000		390,000	662,000	397,000	-809,000	-275,000	1,949,000	2,258,000																											521,000			1,228,000							-300,000	-566,000	-85,000	571,000	1,931,000	2,454,000	-736,000	-3,005,000	-748,000
retained earnings	517,099,000							329,933,000	160,385,000
total stockholders’ equity	5,622,847,000	4,651,194,000	4,170,903,000	3,667,563,000	3,447,628,000	3,171,220,000	2,997,059,000	5,394,271,000	5,189,837,000	4,931,447,000	4,740,692,000	4,462,568,000	4,370,119,000	4,226,651,000	4,085,061,000	3,863,072,000	3,770,004,000	3,148,657,000	2,935,861,000	2,727,844,000	2,611,268,000	2,390,833,000	2,344,604,000	1,937,721,000	2,598,406,000	2,422,527,000	2,247,191,000	2,085,567,000	1,925,967,000	1,802,899,000	1,732,923,000	1,628,044,000	1,630,629,000	1,757,750,000	1,026,835,000	965,934,000	419,467,000	369,986,000	297,063,000	227,748,000	171,155,000	88,737,000	55,174,000					28,791,000																											3,515,000	33,751,000	59,868,000	78,517,000	30,760,000	52,632,000	117,818,000	154,333,000	194,065,000	237,356,000	264,009,000	302,410,000	370,482,000	404,272,000	421,411,000
total liabilities and stockholders’ equity	7,339,113,000	6,330,356,000	5,821,354,000	5,749,365,000	5,444,322,000	5,012,434,000	4,661,803,000	7,135,605,000	6,782,107,000	6,388,239,000	6,208,259,000	5,797,623,000	5,840,984,000	5,510,214,000	5,319,035,000	5,054,221,000	4,933,352,000	4,198,831,000	3,904,623,000	3,661,436,000	3,560,918,000	3,307,430,000	3,212,321,000	2,752,422,000	3,426,750,000	3,214,818,000	2,947,633,000	2,754,161,000	2,645,762,000	2,519,947,000	2,397,157,000	2,306,012,000	2,302,582,000	2,374,301,000	1,639,443,000	1,607,347,000	1,638,597,000	1,544,195,000	1,417,975,000	1,103,942,000	1,007,440,000	931,932,000																																374,108,000	398,109,000	436,647,000	487,458,000	516,919,000	470,504,000	538,118,000	582,468,000	379,545,000	415,437,000	470,475,000	496,878,000	552,139,000	603,054,000	645,736,000	666,847,000
accumulated deficit		-85,510,000	-509,679,000	-914,678,000						-40,694,000	-211,963,000	-415,511,000	-437,214,000	-465,675,000	-578,450,000	-739,882,000	-777,874,000	-1,341,725,000	-1,523,464,000	-1,672,920,000	-1,726,455,000	-1,876,305,000	-1,861,102,000	-2,151,400,000	-1,430,758,000	-1,541,763,000	-1,670,034,000	-1,775,352,000	-1,877,759,000	-1,946,822,000	-1,975,998,000	-2,028,392,000	-1,990,005,000	-1,840,376,000	-1,876,430,000	-1,863,946,000	-1,674,765,000	-1,683,638,000	-1,720,515,000	-1,754,940,000	-1,778,987,000	-1,834,163,000																																			-756,435,000	-736,304,000	-698,778,000	-672,802,000	-609,202,000	-571,487,000	-530,720,000	-487,708,000	-460,808,000	-405,024,000	-337,532,000	-299,121,000	-281,580,000
accumulated other comprehensive loss				-6,238,000										-29,062,000	-25,696,000	-23,047,000	-19,454,000	-18,646,000	-18,273,000	-20,358,000	-15,360,000	-9,748,000	-12,423,000	-13,107,000	-15,542,000	-8,614,000	-8,965,000	-9,247,000	-10,165,000	-9,522,000	-9,809,000	-10,122,000	-7,010,000				-2,886,000																																								-707,000	-2,226,000	-1,188,000	-4,034,000
(accumulated deficit) retained earnings					-1,072,881,000	-1,274,093,000	-1,380,446,000
short term equity investments						3,344,000	69,875,000
long term investments								287,663,000	187,716,000	153,663,000	170,316,000	128,313,000	133,676,000	149,124,000	149,784,000	174,681,000	221,266,000	192,096,000	220,691,000	202,174,000	222,301,000	222,810,000	248,731,000	180,993,000	133,657,000	117,902,000	115,563,000	120,188,000	99,199,000	121,381,000	131,330,000	165,972,000	134,356,000	169,020,000	144,425,000	158,322,000
restricted cash and investments														1,601,000	1,644,000	1,700,000	1,720,000	1,682,000	1,679,000	1,643,000	1,757,000	2,663,000	2,583,000	2,548,000	1,023,000	995,000	1,014,000	995,000	1,006,000	1,009,000	1,000,000	947,000	925,000	926,000	943,000	902,000	16,000	17,000	16,000	517,000	516,000	517,000									9,500,000	9,499,000	19,295,000	18,997,000	18,990,000
convertible senior notes																						11,900,000	18,588,000	18,524,000	18,300,000	18,080,000	17,862,000	17,647,000		7,648,000	7,554,000	7,460,000	7,393,000	23,711,000	23,428,000	41,604,000	651,481,000	643,434,000	635,491,000	627,642,000		5,000	42,940,000	87,337,000	681,313,000	673,315,000	665,222,000	187,136,000	214,530,000	328,354,000	315,874,000	309,844,000	303,952,000	292,566,000	287,067,000	281,694,000	271,315,000	266,304,000	261,408,000	311,503,000	135,598,000	133,263,000	128,714,000	126,498,000	124,320,000		120,076,000	118,009,000	115,977,000	113,981,000	112,018,000

interest payable																						56,000	29,000	89,000	29,000	89,000	30,000	89,000	29,000	100,000	33,000	100,000	33,000	100,000	34,000	135,000	762,000	2,285,000	762,000	2,285,000	762,000	3,316,000	1,282,000	4,443,000	4,456,000	1,850,000	4,462,000	6,087,000	3,044,000	9,500,000	9,500,000	4,750,000	9,500,000	9,500,000	4,750,000	9,500,000	9,500,000	4,750,000	9,553,000	987,000	5,273,000	1,758,000	1,758,000	5,273,000	1,758,000		1,758,000	5,273,000	1,758,000	4,668,000	2,009,000	5,382,000	1,935,000	5,382,000	1,935,000	5,553,000	2,268,000	6,217,000	2,346,000	7,077,000	2,601,000	3,816,000		3,903,000	1,561,000	3,903,000
finance lease right-of use assets																											30,348,000
in-process research and development																																			12,000,000	12,000,000	12,000,000	12,000,000	12,000,000
long term investment																																					31,987,000	55,745,000	31,444,000	32,298,000	35,248,000	35,714,000	67,003,000	39,829,000
deferred revenue—collaborative agreements																																						2,868,000	6,083,000	9,297,000	12,512,000	12,857,000	12,857,000	12,857,000	12,882,000	12,885,000
stockholders’ equity
deferred income taxes																																										9,712,000	7,725,000	6,025,000	775,000	900,000	892,000
restricted investments																																											517,000	500,000	500,000	750,000	625,000
stockholders’equity
total liabilities and stockholders’equity																																											930,337,000					357,400,000
liabilities and stockholders’ deficit
stockholders’deficit:
total stockholders’ deficit
total liabilities and stockholders’deficit																																												862,624,000	785,265,000	679,107,000	666,826,000		334,219,000	330,282,000		311,971,000	293,593,000	371,224,000	416,663,000	459,606,000		493,681,000	502,663,000	472,816,000	159,016,000	189,635,000	264,718,000	204,735,000	237,011,000				324,933,000				398,756,000
accumulated other comprehensive gain																																													1,914,000	2,080,000	2,040,000	2,008,000	1,993,000	1,999,000	2,149,000	1,720,000	1,935,000	1,821,000	1,951,000	2,089,000	1,930,000	1,795,000	1,198,000	502,000
deferred revenue-collaborative agreements																																															12,887,000	25,503,000	39,029,000	52,554,000	66,973,000	66,976,000	66,978,000
intangible and other assets																																																2,508,000	3,204,000	5,543,000	6,620,000	7,154,000	7,686,000			9,793,000				14,641,000	3,099,000	3,837,000	4,837,000	5,559,000	5,876,000		7,038,000	7,610,000	8,204,000	8,715,000	9,354,000	9,785,000	10,408,000	11,097,000	11,783,000	12,519,000	13,607,000	14,220,000	27,395,000	30,030,000	32,231,000	25,085,000	28,609,000	28,543,000	27,434,000	26,066,000	24,679,000	27,262,000
convertible subordinated note																																																	9,287,000	9,159,000	9,816,000	9,680,000	9,546,000
deferred revenue-product revenues																																																				8,993,000	6,005,000
stockholders’ deficit:
total liabilities and stockholders’ deficit																																																			296,535,000						464,640,000										282,683,000	308,798,000		353,603,000	464,886,000	375,112,000
deferred revenue																																																						66,973,000	66,976,000	66,978,000	66,980,000	67,000,000	67,020,000	32,000	52,000	72,000	32,000	52,000	72,000		5,995,000	11,630,000	17,687,000	22,883,000	22,935,000	22,934,000	22,997,000	604,000	742,000	751,000	2,225,000	1,807,000	4,172,000	3,523,000	4,030,000	6,401,000	8,922,000	15,071,000	13,048,000	11,662,000	15,516,000	16,857,000	20,531,000
accrued restructuring																																																									1,664,000	4,277,000	5,688,000	6,729,000	6,009,000	5,145,000	4,752,000	4,714,000	5,014,000				5,007,000	4,970,000
convertible subordinated notes																																																						17,711,000	17,467,000	17,225,000	16,753,000	16,521,000	16,292,000	165,916,000	265,627,000	265,411,000	264,988,000	264,781,000	264,577,000		257,427,000	257,324,000	257,222,000	257,122,000	91,690,000	91,747,000	91,804,000	341,862,000	341,919,000	349,506,000	378,686,000	378,766,000	378,846,000	417,578,000	417,682,000	167,786,000	167,890,000	171,823,000	171,930,000	172,036,000	172,143,000	172,250,000	179,137,000
embedded derivative liability on 4.75% convertible senior notes																																																												148,105,000
preferred stock
revenues:
costs and expenses:
income from operations
interest and other income
interest expense
loss on certain derivative financial instruments
gain on redemption/repurchase of convertible subordinated notes
income from continuing operations before income taxes
benefit for income taxes
income from continuing operations
gain from discontinued operation, net of tax
basic and diluted per share data:
shares used in computing basic and diluted net income per share
accrued restructuring and acquisition costs																																																																			4,814,000	5,148,000			5,068,000	5,514,000	5,808,000	5,584,000	5,261,000	5,557,000	5,489,000	5,873,000	38,326,000	41,261,000
long-term investments																																																																									1,404,000	1,368,000	7,386,000	7,387,000	7,348,000	11,427,000	11,755,000	13,158,000	13,272,000	16,196,000	18,208,000	31,358,000	33,749,000	35,515,000	44,644,000	45,690,000	49,297,000
assets of discontinued operation																																																																														2,264,000
liabilities of discontinued operation																																																																														2,549,000
deferred stock-based compensation																																																																													-135,000	-186,000				-649,000			-2,749,000	-3,250,000
common stock																																																																															73,000	73,000	73,000		72,000	72,000	72,000		68,000	67,000	67,000
deferred compensation																																																																															-281,000	-402,000	-524,000		-1,315,000	-2,251,000			-4,038,000	-5,767,000	-6,634,000
royalties payable																																																																																	979,000	1,025,000				926,000
accrued restructuring charges																																																																																	21,634,000	22,702,000	16,024,000	18,014,000	19,793,000	31,596,000	8,122,000	11,016,000	11,510,000
accrued acquisition costs																																																																																	1,630,000	1,334,000	1,980,000	2,964,000	3,517,000
accrued and other liabilities																																																																																				4,772,000
other accrued liabilities																																																																																								18,042,000
intangible assets																																																																																									2,786,000
deposits and other assets																																																																																									22,015,000

Cashflow Statements:

Quarterly

Annual

Unit: USD	2026-03-31	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-09-30	2014-06-30	2014-03-31	2013-09-30	2013-06-30	2013-03-31	2012-09-30	2012-06-30	2012-03-31	2011-09-30	2011-06-30	2011-03-31	2010-09-30	2010-06-30	2010-03-31	2009-09-30	2009-06-30	2009-03-31	2008-09-30	2008-06-30	2008-03-31	2007-09-30	2007-06-30	2007-03-31	2006-12-31	2006-09-30	2006-06-30	2006-03-31	2005-12-31	2005-09-30	2005-06-30	2005-03-31	2004-12-31	2004-09-30	2004-06-30	2004-03-31	2003-12-31	2003-09-30	2003-06-30	2003-03-31	2002-12-31	2002-09-30	2002-06-30	2002-03-31

cash flows from operating activities:
net income	303,330,000	424,169,000	404,999,000	158,203,000	201,212,000	106,456,000	-444,601,000	169,548,000	201,079,000	171,269,000	203,548,000	21,703,000	28,461,000	112,775,000	161,432,000	37,992,000	563,851,000	181,739,000	149,456,000	53,535,000	149,850,000	-15,203,000	290,298,000	-720,642,000	111,005,000	128,271,000	105,318,000	102,312,000	69,063,000	29,176,000			-149,629,000	36,054,000	-12,484,000	-187,083,000	8,873,000	36,877,000	34,425,000	24,047,000
adjustments to reconcile net income to net cash from operating activities:
depreciation and amortization	23,802,000	24,023,000	22,919,000	22,362,000	22,733,000	22,520,000	22,048,000	21,947,000	21,762,000	21,390,000	20,297,000	19,211,000	18,218,000	16,692,000	16,507,000	16,438,000	14,858,000	14,691,000	14,457,000	13,838,000	13,166,000	12,949,000	12,594,000	13,098,000	13,345,000	13,862,000	13,435,000	13,891,000	14,226,000	13,818,000	13,501,000	13,424,000	12,859,000	11,940,000	12,352,000	15,027,000	17,566,000	16,951,000																6,871,000	6,647,000	6,430,000	5,378,000	5,885,000	6,396,000	4,273,000	2,636,000	2,509,000	3,250,000	3,272,000	3,288,000	3,253,000	3,261,000	3,199,000	3,271,000	1,302,000	1,229,000	1,609,000	1,676,000	3,955,000	708,000	1,853,000	2,928,000	4,143,000	3,597,000	3,245,000	4,242,000	4,504,000	4,482,000	4,457,000	6,343,000	5,609,000	5,885,000	5,369,000
stock-based compensation	64,126,000	61,598,000	64,609,000	60,982,000	71,718,000	77,922,000	56,640,000	59,778,000	59,990,000	48,000,000	54,520,000	53,379,000	52,679,000	45,404,000	46,496,000	43,841,000	48,222,000	42,694,000	44,732,000	47,358,000	45,261,000	43,800,000	46,303,000	42,513,000	42,023,000	43,359,000	40,615,000	40,592,000	37,323,000	38,001,000	36,605,000	36,224,000	33,768,000	34,929,000	33,745,000	30,613,000	27,603,000	26,527,000	21,302,000	20,769,000	17,097,000	17,625,000	17,592,000	17,558,000	15,428,000	15,478,000	15,347,000	9,447,000	9,933,000	9,197,000	9,583,000	9,911,000	9,932,000	7,399,000	7,191,000	6,946,000	4,059,000	3,555,000	3,121,000	2,196,000	2,497,000	3,360,000	3,857,000	3,945,000	3,345,000	2,631,000	2,601,000	2,210,000	2,250,000	2,059,000	2,254,000	2,327,000	34,000	50,000	51,000	51,000
deferred income taxes	63,416,000	124,117,000	116,777,000	-6,706,000	56,000	-33,876,000	-17,482,000	-34,251,000	-65,979,000	-31,055,000	-39,701,000	-22,163,000	16,659,000	7,957,000	30,369,000	2,106,000	-465,426,000	-18,000
other	12,772,000	6,665,000	-8,512,000	5,292,000	-4,229,000	-7,412,000	-366,000	2,954,000	23,122,000	3,127,000	-1,019,000	-2,651,000		6,630,000	6,376,000	2,091,000	-3,851,000	2,054,000	-1,408,000	4,622,000	-8,152,000	131,000	8,422,000	145,000	130,000	129,000	123,000	104,000	86,000	86,000	85,000	87,000	74,000	70,000	75,000	71,000	147,000	74,000	73,000	178,000																																															1,223,000	-1,150,000
loss on equity investments	-6,591,000		4,151,000	1,343,000
loss on change in fair value of acquisition-related contingent consideration	-168,000	-12,204,000	22,761,000	11,572,000	-4,044,000	23,410,000	893,000	-456,000	15,058,000	-426,000	8,374,000	6,196,000	24,347,000
changes in operating assets and liabilities:
accounts receivable	-27,027,000	-53,001,000	-20,229,000	30,955,000	-96,693,000	-19,400,000	6,476,000	-1,969,000	-86,294,000	-19,269,000	-14,206,000	21,091,000	-26,691,000	64,780,000	-120,624,000	53,956,000	-99,611,000	-78,519,000	-40,813,000	84,637,000	-117,529,000	64,068,000	-77,011,000	-42,713,000	-32,693,000	26,564,000	-58,599,000	63,517,000	-59,862,000	68,574,000	-96,120,000	46,109,000	-67,954,000	-28,829,000	75,459,000	-96,217,000	-17,235,000	-3,894,000	-15,988,000	13,170,000	-27,484,000							-5,675,000	519,000	42,910,000				-86,000			1,625,000	-1,107,000	158,408,000	-54,000	-68,000	311,000	-92,000	53,000	711,000	-9,000	173,000	633,000		-44,000			-376,000	-115,000	1,616,000	-404,000	31,000	657,000	573,000	1,824,000	4,446,000	-2,664,000	318,000	652,000	6,295,000	10,349,000	2,562,000	26,347,000
prepaid expenses and other assets	9,193,000	-72,835,000	-86,395,000	-62,045,000	65,746,000	-15,633,000	-38,050,000	-1,698,000	19,590,000	-53,862,000	16,135,000	-24,354,000	9,277,000	-14,636,000	-11,409,000	-13,971,000	-39,296,000	-21,803,000	7,796,000	-10,777,000	3,334,000	279,000	5,038,000	-16,701,000	-4,255,000	1,645,000	2,795,000	5,559,000	-12,082,000	2,259,000	-4,667,000	-18,922,000	684,000	1,441,000	-8,398,000	-25,094,000	254,000	-5,863,000	-3,793,000	-3,667,000	5,501,000	-2,864,000						-832,000			-78,000	8,419,000	29,000	-1,638,000			1,142,000			-113,000	2,553,000	380,000				1,037,000	-254,000	1,949,000	-2,781,000	643,000	1,130,000	1,594,000	-1,810,000	-349,000	1,284,000	877,000	-4,293,000	807,000	3,098,000	901,000	-1,737,000	-3,980,000	4,671,000	-1,184,000	-3,688,000	-2,189,000	-2,046,000	-2,138,000
inventory	-12,226,000	-5,555,000	-19,525,000	-28,574,000	-34,281,000	-8,376,000	-27,779,000	-57,197,000	-92,958,000	-23,757,000	-20,116,000	-33,320,000	-19,188,000	-11,126,000	-23,287,000	-13,903,000	-4,750,000	72,000	-11,881,000	-4,406,000	-10,264,000	180,000	-3,672,000	-5,712,000	-3,187,000	-625,000	-1,688,000	-600,000	1,013,000	1,152,000	-1,000	1,879,000	110,000	279,000	3,672,000	790,000	-392,000	2,757,000	930,000	752,000	928,000			1,000									23,000
accounts payable	23,449,000	-44,166,000	19,911,000	-2,159,000	19,050,000	30,536,000	-16,064,000	54,637,000	-29,810,000	-16,127,000	99,905,000	-221,913,000	114,371,000	-31,595,000	42,223,000	-19,563,000	57,601,000	-7,591,000	37,042,000	-13,709,000	-23,745,000	31,603,000	29,972,000	-22,710,000	-11,729,000	23,792,000	1,221,000	-33,464,000	8,349,000	19,919,000	1,444,000	6,444,000	-2,262,000	840,000	-17,234,000	10,728,000	18,075,000	16,800,000	7,069,000	1,814,000	2,719,000	-1,796,000	2,576,000	2,124,000	-646,000					1,554,000													-16,000	253,000	5,422,000				2,212,000	-1,673,000	-532,000	2,336,000	-799,000	189,000	1,861,000	1,000	-651,000	-2,060,000	-480,000	-960,000	-707,000	1,741,000	-2,050,000	-2,415,000	1,857,000	-1,231,000	1,962,000	-862,000
accrued and other liabilities	-84,725,000	115,136,000	-476,725,000	74,842,000	129,769,000	121,742,000	-78,037,000	105,465,000	116,223,000	21,891,000	20,600,000	71,900,000	47,812,000	120,733,000	-2,136,000	53,787,000	46,402,000	91,419,000	-4,144,000	-2,238,000	51,646,000	23,992,000	23,658,000	14,546,000	29,989,000	32,476,000	38,507,000	-21,930,000	-3,466,000	11,494,000	-12,782,000	-7,273,000	51,533,000	23,787,000	2,209,000	10,227,000	11,458,000	24,546,000	-39,207,000	29,679,000	8,776,000	8,603,000	6,676,000	1,190,000
net cash from operating activities	369,351,000	559,389,000	44,741,000	266,067,000	381,218,000	310,871,000	-575,563,000	218,811,000	147,729,000	147,835,000	306,526,000	-105,603,000	283,662,000	296,381,000	174,157,000	215,741,000	115,351,000	255,098,000	172,944,000	206,095,000	107,321,000	182,115,000	269,382,000	-683,417,000	131,618,000	270,415,000	152,960,000	155,663,000	83,838,000	199,148,000	32,403,000	20,838,000	-89,267,000	53,123,000	116,794,000	-173,638,000	94,378,000	95,271,000	17,572,000	97,535,000	70,009,000	7,723,000						-11,950,000	8,081,000	24,738,000																						15,602,000				-26,273,000	-27,489,000	-24,734,000	-25,935,000	-36,509,000	-19,959,000	-40,000,000	-15,623,000	-42,750,000	-19,602,000	-23,837,000	-8,807,000	-6,020,000
cash flows from investing activities:
sale of equity investments		1,000	-1,000	8,000	1,915,000	55,609,000
capital expenditures	-10,200,000	-14,747,000	-19,074,000	-3,169,000	-17,384,000	-5,187,000	-54,143,000	-9,549,000	-2,267,000	-10,976,000	-7,337,000	-11,906,000	-21,273,000	-27,811,000	-11,743,000	-17,006,000	-34,463,000	-32,153,000	-66,307,000	-48,083,000	-51,433,000	-52,821,000	-43,860,000	-39,265,000	-29,315,000	16,812,000	-47,294,000	-18,267,000	-25,281,000	-24,821,000	-10,791,000	-12,590,000	-25,251,000	-34,304,000	-30,499,000	-20,967,000	-15,872,000	-16,629,000	-82,214,000	-5,562,000	-6,896,000	0						0	0	0																						0				-95,000	-569,000	-362,000	-342,000	-118,000	-1,042,000	-1,737,000	-1,375,000	-5,584,000	-1,403,000	-3,776,000	-4,716,000	-1,995,000
free cash flows	359,151,000	544,642,000	25,667,000	262,898,000	363,834,000	305,684,000	-629,706,000	209,262,000	145,462,000	136,859,000	299,189,000	-117,509,000	262,389,000	268,570,000	162,414,000	198,735,000	80,888,000	222,945,000	106,637,000	158,012,000	55,888,000	129,294,000	225,522,000	-722,682,000	102,303,000	287,227,000	105,666,000	137,396,000	58,557,000	174,327,000	21,612,000	8,248,000	-114,518,000	18,819,000	86,295,000	-194,605,000	78,506,000	78,642,000	-64,642,000	91,973,000	63,113,000	7,723,000						-11,950,000	8,081,000	24,738,000																						15,602,000				-26,368,000	-28,058,000	-25,096,000	-26,277,000	-36,627,000	-21,001,000	-41,737,000	-16,998,000	-48,334,000	-21,005,000	-27,613,000	-13,523,000	-8,015,000
payments for intangible assets	-5,000,000				0	-12,500,000			0	0	0	-15,000,000
purchases of marketable securities	-142,703,000	-115,506,000	-56,110,000	-41,236,000	-29,384,000	-24,895,000	-38,283,000	-165,808,000	-233,792,000	-69,951,000	-97,390,000	-54,887,000	-20,802,000	-15,070,000			-6,997,000	-125,882,000	-62,987,000	-39,301,000	-98,176,000	-131,279,000	-140,016,000	-147,403,000	-152,652,000	-118,187,000	-69,396,000	-34,574,000	-55,704,000	-45,401,000	-20,794,000	-38,033,000	-128,861,000	-16,665,000	-8,983,000	-106,271,000	-30,451,000	-9,126,000	-1,000,000	-16,795,000	-13,776,000																			6,000			-23,000	-1,189,000	1,241,000											-86,155,000	-211,321,000	-148,917,000	-46,642,000	-423,614,000	-70,637,000	-169,148,000	-201,290,000	-134,408,000	-175,942,000	-205,096,000	-248,092,000	-120,222,000
maturities of marketable securities	69,700,000	107,836,000																																									21,250,000	19,274,000	134,000	157,000	90,000
net cash from investing activities	-88,203,000	-47,416,000	-18,872,000	1,097,000	-21,465,000	38,274,000	213,820,000	-73,112,000	-154,500,000	-17,189,000	-7,429,000	-28,559,000	-20,912,000	-28,402,000	-12,480,000	-16,748,000	-66,047,000	-32,754,000	-49,145,000	-59,753,000	-102,730,000	-14,453,000	-43,258,000	-108,560,000	-30,028,000	12,284,000	-45,147,000	-24,563,000	-36,097,000	-17,876,000	-3,922,000	-28,528,000	-143,002,000	-30,839,000	-37,318,000	-138,819,000	-36,012,000	-9,952,000	-215,281,000	28,757,000	-4,529,000															24,000	855,000	9,674,000	6,516,000	5,995,000						85,648,000					7,458,000	11,470,000				-1,117,000	-5,288,000	-12,207,000	40,999,000	-100,664,000	34,588,000	35,285,000	25,889,000	30,589,000	31,259,000			59,061,000
cash flows from financing activities:
proceeds from issuance of common stock under stock plans	97,925,000	43,430,000	14,884,000	3,239,000	33,059,000	1,282,000	14,483,000	477,000	7,517,000	-48,000	14,379,000	13,988,000	18,126,000	5,297,000	21,294,000	16,398,000			11,016,000	20,028,000	18,709,000	7,783,000	69,194,000	14,619,000	29,516,000	3,111,000	15,191,000	15,481,000	9,462,000	2,437,000	15,448,000	2,595,000	8,210,000	9,093,000	15,725,000	33,736,000	17,505,000	8,363,000	13,886,000	10,219,000	9,565,000	13,913,000	33,778,000	29,180,000	6,539,000	12,779,000	44,833,000	28,364,000	9,780,000	17,777,000	8,914,000	17,894,000	13,421,000	1,073,000	12,512,000	4,129,000	3,383,000	2,434,000	4,227,000	282,000			550,000	1,562,000	520,000	74,000	844,000	95,000	431,000	23,000	716,000	238,000	536,000	86,000	819,000	48,000	2,907,000	1,137,000	2,026,000	761,000	789,000	91,000	1,109,000	8,000	1,266,000	1,271,000	1,774,000	2,871,000
tax withholdings related to restricted and performance share vesting	-6,956,000	-50,103,000	-912,000	-9,454,000	-886,000	-32,551,000	-691,000	-6,174,000	-489,000	-24,633,000	-675,000	-2,753,000	-577,000	-18,870,000	-4,693,000	-2,161,000
payment of finance lease liabilities	-1,184,000	-1,141,000	-1,155,000	-1,090,000	-1,037,000	-979,000	-911,000	-871,000	-837,000	-885,000	-836,000	-802,000	-756,000	-738,000	-700,000	-668,000	-629,000	-615,000	-600,000	-573,000	-217,000	-232,000	-200,000	-187,000	-196,000	-217,000	-214,000	-195,000
payment of contingent consideration	-4,963,000	-4,964,000	-4,963,000	-5,371,000	-10,742,000	0	-5,371,000	-5,845,000	-5,845,000	-11,690,000	0	-6,424,000	-19,273,000	0	0	-13,473,000	0	-6,736,000	-6,737,000	-6,620,000	-6,620,000	-6,620,000	-12,587,000	-11,933,000	0	0	-5,967,000	-10,799,000	-5,399,000	0			-4,486,000	-4,486,000	-4,356,000	-3,679,000	-3,680,000
net cash from financing activities	84,822,000	-12,778,000	-11,246,000	-12,676,000	20,394,000	-32,351,000	-1,997,177,000	-12,413,000	346,000	-37,256,000	12,868,000	4,009,000	-2,480,000	-14,311,000	15,901,000	96,000	9,005,000	-19,343,000	3,679,000	12,835,000	11,872,000	931,000	56,407,000	2,499,000	29,320,000	2,894,000	9,010,000	4,487,000	4,063,000	2,437,000	5,562,000	2,595,000	3,725,000	654,011,000	10,491,000	21,944,000	13,872,000	7,126,000	27,763,000	9,884,000	10,158,000			32,686,000	6,644,000	12,779,000	44,537,000	26,873,000	9,000	17,777,000	8,914,000	17,894,000	13,421,000	1,073,000	12,512,000	4,129,000				281,034,000						74,000				111,930,000	716,000	10,238,000				48,000	86,226,000	-37,275,000	2,026,000	243,261,000	789,000			-97,000	-4,458,000	1,271,000	-2,898,000	2,926,000
effect of exchange rates on cash, cash equivalents, and restricted cash	-2,689,000	841,000	-1,197,000	-552,000	3,458,000	128,000	13,000	-676,000
net increase in cash, cash equivalents, and restricted cash	363,281,000	500,036,000	13,426,000	253,936,000	383,605,000	316,922,000	-2,358,907,000	132,610,000
cash, cash equivalents, and restricted cash at beginning of period	3,099,669,000	0	0	1,689,451,000	0	0	0	3,215,221,000
cash, cash equivalents, and restricted cash at end of period	3,462,950,000	500,036,000	13,426,000	1,943,387,000	383,605,000	316,922,000	-2,358,907,000	3,347,831,000
supplemental schedule of cash flow information
income taxes paid, net of	-8,787,000
unpaid excise tax on repurchase of common stock				19,185,000	0	0
unpaid purchases of property and equipment	1,633,000	112,000	1,156,000	2,890,000	-941,000	2,738,000	417,000	383,000	5,041,000	-4,409,000	1,361,000	3,059,000	-5,343,000	-116,000	-6,812,000	15,764,000	3,206,000	-6,931,000	9,561,000	21,262,000	9,971,000	-1,981,000	1,235,000	13,582,000				8,414,000					-5,131,000	-92,000	1,727,000	9,139,000
leased assets obtained in exchange for new operating lease liabilities	572,000	1,395,000	597,000	1,171,000	7,238,000	248,000			0	0	4,466,000	809,000	3,095,000	1,625,000	407,000	1,618,000	5,348,000	1,851,000	5,319,000	1,898,000	6,888,000	4,300,000	6,736,000	1,984,000	921,000	4,328,000	1,426,000	932,000
leased assets obtained in exchange for new finance lease liabilities	279,000	134,000	84,000	220,000	6,947,000	491,000	918,000	550,000	1,081,000	152,000	639,000	385,000	414,000	140,000	724,000	584,000	1,058,000	47,000	340,000	68,000	0	1,631,000			149,000	0	29,095,000	645,000
(gain) on equity investments
repurchases of common stock						-103,000
excise tax paid on repurchase of common stock		0
income taxes paid		7,302,000	177,075,000	844,000	70,196,000	73,186,000	226,983,000	2,691,000	125,026,000	115,867,000	130,206,000	7,107,000	19,705,000	40,073,000	72,992,000	3,472,000	21,859,000	9,876,000	35,657,000	339,000	13,955,000	32,592,000	23,310,000	855,000	21,155,000	5,959,000	5,991,000	448,000	2,485,000	988,000	1,892,000	52,000	118,000	626,000	3,317,000	2,244,000	210,000	488,000										0
cash paid for contract dispute settlement		0
unpaid purchase of intangible asset
sale and maturities of marketable securities				45,494,000	23,388,000	25,247,000	80,389,000	102,245,000	81,559,000	73,738,000	97,298,000	53,189,000	21,163,000	14,479,000	43,251,000	258,000	261,000	124,136,000	71,901,000	35,213,000	46,879,000	156,933,000	136,082,000	173,576,000	151,939,000	113,659,000	71,543,000	28,278,000	44,888,000	52,346,000	27,662,000	31,032,000	11,110,000	20,130,000	2,164,000	112,310,000	10,202,000	13,923,000	12,778,000	51,114,000	16,143,000
realized and unrealized loss on equity investments
purchase of long term investments									0								-24,848,000	0			0	0	0	-95,468,000					0	0	1,000	-8,937,000	0	0	0	-123,891,000
repurchase of common stock																																																																																	0	0	0	-105,000
realized and unrealized gain on equity investments						12,982,000
unrealized loss on long term investments								-99,947,000	-34,054,000	26,654,000	-41,811,000	5,318,000	15,448,000	660,000	24,897,000	46,585,000	-4,322,000	27,450,000	-26,765,000	27,709,000				48,132,000	-15,755,000	-2,339,000			22,182,000	9,949,000	34,641,000	-22,679,000	21,932,000	-23,045,000	19,574,000	5,814,000
sale of long term investments									0	0	0	45,000					0	1,145,000
effect of exchange rates on cash, cash equivalents, restricted cash and investments										2,715,000	-1,891,000	-199,000		1,530,000	988,000	210,000	148,000	-1,559,000	172,000	-2,331,000	-2,136,000	2,532,000	993,000	1,560,000	-221,000	187,000	-284,000	126,000
net increase in cash, cash equivalents, restricted cash and investments										96,105,000	310,074,000	-130,352,000		255,198,000	178,566,000	199,299,000	58,457,000	201,442,000	127,650,000	156,846,000	14,327,000	171,125,000	283,524,000	-787,918,000	130,689,000	285,780,000	116,539,000	135,713,000	51,798,000	183,671,000
cash, cash equivalents, restricted cash and investments at beginning of period										0	0	2,953,120,000		0	0	2,059,160,000	0	0	0	1,514,765,000	0	0	0	1,833,707,000	0	0	0	1,164,986,000	0	0	0	900,434,000
cash, cash equivalents, restricted cash and investments at end of period										96,105,000	310,074,000	2,822,768,000	260,897,000	255,198,000	178,566,000	2,258,459,000	58,457,000	201,442,000	127,650,000	1,671,611,000	14,327,000	171,125,000	283,524,000	1,045,789,000	130,689,000	285,780,000	116,539,000	1,300,699,000	51,798,000	183,671,000	34,143,000	895,374,000
unrealized foreign exchange losses and other
reclassification to common stock and additional paid in capital in connection with conversions of 1.25% convertible senior notes due 2020																					12,007,000	6,830,000											0	1,000	1,628,000	328,382,000	0	0	0	4,000
change in fair value of acquisition-related contingent consideration															3,313,000	6,382,000	1,673,000	2,910,000	4,632,000	5,526,000	3,595,000	7,109,000	6,054,000	6,627,000	3,122,000	3,281,000	6,608,000	6,671,000	7,465,000	4,720,000	7,303,000	6,685,000	9,618,000	-16,343,000	7,073,000	7,356,000	7,139,000	8,012,000
interest paid																					75,000	0			120,000	0			134,000	0			134,000	0			3,326,000	0	3,046,000	846,000	5,048,000	6,028,000	831,000	839,000	4,000			0
proceeds from issuance of common stock under stock plans net of tax withholding
purchase of long term investment																				-8,662,000
sale of long term investment																				1,080,000	0	12,714,000
reclassification to common stock and additional paid in capital in connection with conversions of 0.375% convertible senior notes due 2018																													7,664,000	2,000	2,000	27,000	3,000	7,000	16,872,000	334,162,000	0
unrealized gain on long term investments																						13,207,000						-20,989,000
in-process research and development impairment																																	0
expense related to senior note conversions																																	0	0	751,000	54,130,000
proceeds from issuance of common stock																																	0
cash paid in connection with senior note conversions																																	0	0	-837,000	-8,097,000
deferred revenue—collaborative agreements																																					-2,868,000	-3,215,000	-3,214,000	-3,215,000	-3,214,000
acquisition of business, net of cash acquired																																					109,000	1,880,000
direct financing arrangements repayments																																					0	0	0	-445,000	-320,000
effect of exchange rates on cash and cash equivalents																														-38,000	100,000	35,000	7,000	-3,000				0
net loss																																-41,140,000									55,176,000	-39,582,000	9,296,000	-18,359,000	59,292,000	-36,873,000	-33,957,000	-22,036,000	-2,571,000	-15,669,000	-21,710,000	4,037,000	-45,426,000	-53,078,000	-51,871,000	-26,512,000	-31,702,000	3,044,000	-35,729,000	-43,357,000	-40,035,000	-40,036,000	-44,794,000	-45,564,000	-40,157,000	-24,494,000	-18,439,000	-22,147,000		-15,837,000	-20,520,000	-17,306,000		-30,211,000	-25,145,000	-20,131,000	-37,526,000	-25,976,000	-63,600,000	-37,715,000	-40,767,000	-43,012,000	-26,900,000	-55,784,000	-67,492,000	-38,411,000	-17,541,000	-13,441,000
adjustments to reconcile net loss to net cash from operating activities:
net decrease in cash, cash equivalents, restricted cash and investments																																-5,060,000
restricted investments																																	1,000	17,000	-41,000	-16,000	47,000	-11,000	13,877,000	110,000	135,000
net increase in cash and cash equivalents																																	-228,537,000			-290,520,000	72,244,000			136,176,000								13,920,000	-7,612,000	41,757,000													72,885,000	-28,029,000	53,887,000	61,694,000	13,637,000	1,437,000								-27,344,000	53,456,000	-74,209,000	17,086,000	106,149,000			11,378,000	-12,291,000			-54,963,000	55,788,000
cash and cash equivalents at beginning of period																																	0	0	0	652,343,000	0	0	0	521,439,000	0	0	0	452,297,000	0	0	471,429,000	0	0	224,057,000	0	0	273,164,000	0	0	417,912,000	0	0	449,824,000	0	0	178,767,000	0	0	108,854,000	0	0	18,861,000		0	0	11,494,000	0	0	0	132,180,000	0	0	0	29,698,000	0	0	0	22,928,000	0	0	0	43,368,000
cash and cash equivalents at end of period																																	-228,537,000	676,292,000	89,931,000	361,823,000	72,244,000	92,445,000	-169,961,000	657,615,000	75,638,000	6,120,000	17,859,000	421,822,000	-24,260,000	-30,321,000	436,585,000	13,920,000	-7,612,000	265,814,000	-18,480,000	25,708,000	231,855,000	-46,746,000	-18,769,000	377,843,000	-25,284,000	9,342,000	404,746,000	253,189,000	-24,809,000	139,098,000	72,885,000	-28,029,000	162,741,000	61,694,000	13,637,000	20,298,000		79,983,000	-12,866,000	48,804,000	-37,703,000	12,020,000	-67,659,000	104,836,000	53,456,000	-74,209,000	17,086,000	135,847,000	15,391,000	-7,708,000	11,378,000	10,637,000	7,192,000	-28,457,000	-54,963,000	99,156,000
reclassification to common stock and additional paid in capital in connection with conversions of 4.75% convertible senior notes due 2015
net decrease in cash and cash equivalents																																									75,638,000
debt exchange expense on senior note conversions																																													0	0	265,000
unrealized loss on long term investment																																					23,758,000	-24,301,000	854,000	2,950,000	466,000
excess tax provision from stock-based compensation
long term investment
cash paid in connection with exchange of 4.75% convertible senior notes due 2015
reclassification to additional paid in capital in connection with conversions or exchanges of 4.75% convertible senior notes due 2015																																										43,635,000
purchase of property and equipment financed by direct financing lease																																													8,565,000	10,444,000	7,806,000
reclassification to additional paid in capital in connection with conversions or exchange of 4.75% convertible senior notes due 2015
excess tax benefit from stock-based compensation
depreciation and amortization of debt discounts																																								11,058,000	10,604,000	11,178,000	11,266,000	11,835,000	9,871,000	9,698,000	9,623,000	4,568,000	8,053,000	7,734,000	7,576,000	7,404,000	7,234,000
incomes taxes paid																																								14,000	-24,000	3,000	70,000	13,000
loss on repurchase of convertible senior notes
excess tax provision from stock based compensation																																									-4,966,000	21,000	-1,760,000	3,833,000
proceeds from issuance of convertible senior notes, net of costs
repurchase of convertible senior notes
foreign currency translation change
reclassification to common stock and additional paid in capital in connection with conversion of pfizer convertible subordinated note due 2014
reclassification to common stock and additional paid in capital in connection with conversions or exchanges of 4.75% convertible senior notes due 2015
reclassification to additional paid in capital in connection with repurchase of 4.75% convertible senior notes due 2015
realized gain on marketable securities
excess tax benefit from stock based compensation																																													43,000	0	31,000
long term investments
unrealized gain on long term investment
deferred revenue — collaborative agreements
direct financing arrangement repayments
net cash provided by financing activities																																																															102,261,000	1,562,000	520,000			95,000
adjustments to reconcile net loss to net cash used in operating activities:
release of restricted investments																																												125,000
reclassification to additional paid in capital in connection with exchange of 4.75% convertible senior notes due 2015																																													210,000	0	4,446,000
restricted cash
reclassification to additional paid in capital in connection with conversion of pfizer convertible subordinated note due 2014
realized gain on restricted cash and investments and marketable securities
debt exchange expense																																																1,491,000
accrued and other current liabilities																																																																												-9,080,000		10,968,000	-8,264,000	-7,127,000	8,184,000	-2,416,000	989,000	-20,893,000	20,413,000	-6,213,000	4,627,000	-15,433,000
deferred revenue — product revenues																																																				2,988,000	3,673,000
sales and maturities of marketable securities																																																		136,000	157,000	97,000	167,000	339,000	530,000	576,000	1,321,000	10,272,000	6,822,000	6,123,000	4,024,000	3,161,000	9,537,000	4,184,000	89,630,000	94,549,000	60,045,000	30,879,000		118,515,000	67,803,000	322,192,000		102,679,000	129,894,000	85,074,000		136,305,000	87,136,000	323,068,000		206,350,000	227,321,000	174,113,000		202,864,000	207,791,000	186,724,000
non-cash reclassification to additional paid in capital in connection with conversion of pfizer convertible subordinated note due 2014
non-cash reclassification to additional paid in capital in connection with exchange of 4.75% convertible senior notes due 2015																																																31,322,000
paid in connection with exchange of 4.75% convertible senior notes due 2015
non-cash restructuring charges																																																						0						1,125,000	406,000	509,000			123,000		-73,000	107,000				201,000
loss on debt redemption																																																									0	0	3,988,000
realized gain on investments
deferred revenue																																																														10,000							-5,642,000	-5,589,000	-5,653,000	36,278,000				418,000	-499,000	649,000	-507,000	-2,371,000	-2,521,000	-6,149,000	2,023,000	1,386,000	-3,854,000	-1,341,000	-3,674,000	-3,514,000
redemption of convertible notes
impairment of marketable securities																																																												0
net cash from (used in) operating activities																																																											102,823,000
proceeds from issuance of common stock, net of offering costs
proceeds from issuance of convertible senior notes, net of offering costs
changes in restricted cash
net cash (used in) provided by financing activities
loss on debt repurchases
repurchases of convertible senior notes and convertible subordinated notes
net cash provided by investing activities																																																														3,066,000	9,372,000	2,927,000	90,749,000			26,694,000
net (decrease) increase in cash and cash equivalents
compensation expense on executive loans																																																																					0	0	0	18,000	57,000	0	0	18,000	19,000	18,000	19,000	19,000	18,000			98,000
realized gain on long-term investment
impairment of long-term investments																																																																													0	2,500,000	0	2,747,000	1,900,000	13,350,000	814,000	1,900,000	9,326,000
proceeds from issuance of convertible senior notes and convertible subordinated notes
realized loss on long-term investment
gain on sale of short-term investment
proceeds from issuance of pfizer convertible subordinated note																																																																							0	10,000,000
gain on sale of short term investment
net cash (used in) provided by operating activities
loss from discontinued operations																																																																												-153,000
non-cash restructuring charges and impairment of long-lived assets																																																																									1,236,000	299,000	447,000	342,000
loss on repurchase of convertible subordinated notes
loss on derivative financial instruments																																																																									17,000	2,000	-39,000	126,000	-16,000	216,000	77,000	177,000	112,000	-200,000	-108,000	45,000	1,464,000	-155,000
realized gain on long-term investments																																																																													0	0			0	-809,000	-434,000	-22,000	-123,000	42,000	-125,000	-981,000
net cash from continuing operating activities																																																																								15,602,000				-26,082,000
net cash from discontinued activities																																																																												-191,000
proceeds from the sale of long-term investments																																																																													0	0			0	809,000			0	105,000	1,828,000	704,000
proceeds from the sale of equipment																																																																													137,000	767,000
sales of marketable securities
investing activities of discontinued operations
net cash provided by (used in) investing activities
redemption/repurchase of convertible subordinated notes
net proceeds from issuance of convertible senior and subordinated notes
net proceeds from issuance of common stock
net cash provided by (used in) financing activities
effect of exchange rate on cash and cash equivalents																																																																												-2,000	7,000	7,000	-4,000	61,000	-27,000	-25,000	3,000	-33,000	-7,000	12,000	-69,000	-179,000
net increase (decrease) in cash and cash equivalents																																																																							-12,866,000	37,310,000
cash and cash equivalents at beginning of year
cash and cash equivalents at end of year
taxes paid
income from discontinued operations
non-cash restructuring (credits) charges
gain on repurchase of convertible subordinated notes																																																																																	0				0	0
impairment of long term investments
net proceeds from sale of proteome facility and equipment																																																																										0
repurchase of convertible subordinated notes																																																																													0				0				0	0
gain from discontinued operations
realized loss on long-term investments
non-cash purchased in-process research and development																																																																																	-414,000
net cash provided (used) in discontinued activities
acquisition of maxia pharmaceuticals, inc.																																																																																				-3,532,000
net proceeds from issuance of convertible subordinated notes																																																																													0	0	0	242,500,000
supplemental disclosure of non-cash activity:
reversal of deferred compensation
realized gain on long term investments
net proceeds from sale of equipment
proceeds from sale of long term investments
investing activities of discontinued operation
net cash from (used in) investing activities
realized gain on long term investments.
net proceeds from sale of proteome facility																																																																												59,000
loss on sale of assets																																																																																					199,000
debt instruments and equity received in exchange for goods or services provided																																																																																					0	0
purchase of long-term investments																																																																																					0
loans to executive officers																																																																																					0	0
non-cash other expenses																																																																														-17,003,000	39,553,000	2,626,000		0	0	393,000
stock compensation																																																																														121,000	122,000	125,000		286,000	498,000	501,000		1,081,000	867,000	1,461,000
acquisition of maxia pharmaceuticals, net of cash acquired																																																																																		-989,000
cumulative effect of accounting change
deferred compensation on restricted stock units
impairment of prepaid and other assets
equity received in exchange for goods or services provided
changes in certain assets and liabilities:
purchased in-process research and development																																																																																			0	28,116,000
compensation expense on loans to executive officers
long-term investments																																																																																							0	-5,000,000
cash from financing activities
losses from joint venture
purchase of subsidiary
proceeds from private equity offering
proceeds from the issuance of convertible subordinated notes
principal payments on capital lease obligations and note payable
cash flow for acquisition of subsidiaries
tangible assets acquired
goodwill and other intangible assets acquired
acquisition costs incurred
liabilities assumed
deferred compensation assumed
common stock issued
cash paid for acquisition
supplemental disclosure of non-cash activity
impairment of assets
net cash provided (used in) in investing activities
gain/loss on derivative financial instruments																																																																																								-140,000
debt instruments or equity received in exchange for goods or services provided																																																																																								-2,688,000

Incyte Corporation(NASDAQ:INCY)

Incyte Corporation
(NASDAQ:INCY)