7Baggers

IDEAYA Biosciences, Inc
(NASDAQ:IDYA) 

IDYA stock logo

IDEAYA Biosciences, Inc., a synthetic lethality-focused precision medicine oncology company, focuses on the discovery and development of targeted therapeutics for patient populations selected using molecular diagnostics. The company's product candidate is IDE196, a protein kinase C inhibitor that is...

Founded: 2015
IPO Price: $10 (May 23, 2019)
Full Time Employees: 58
CEO: Yujiro S. Hata  
Sector: Healthcare
Industry: Biotechnology

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At a glance:
Bull Thesis:
Bear Thesis:
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Moat:
Income Statements:
Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 
                                
      collaboration revenue
    6,560,000 10,876,000 207,834,000       3,922,000 8,038,000 3,544,000 7,880,000 4,022,000 29,699,000 5,851,000 11,359,000 2,962,000 8,976,000 8,756,000 7,247,000 10,571,000 8,967,000      
      total revenue
    6,560,000 10,876,000 207,834,000       3,922,000 8,038,000 3,544,000 7,880,000 4,022,000 29,699,000 5,851,000 11,359,000     10,571,000 8,967,000      
      yoy
      NaN%    NaN% NaN% NaN% -2.49% -72.94% -39.43% -30.63%                
      qoq
    -39.68% -94.77%     NaN% NaN% NaN% -51.21% 126.81% -55.03% 95.92% -86.46% 407.59% -48.49%      17.89%       
      operating expenses
                                
      research and development
    95,726,000 86,599,000 82,993,000 74,226,000 70,886,000 140,183,000 57,152,000 54,533,000 42,805,000 38,770,000 33,701,000 29,178,000 27,859,000 24,713,000 22,372,000 22,796,000 19,656,000 16,110,000 15,503,000 14,979,000 11,566,000 12,051,000 10,025,000 8,596,000 9,026,000 8,541,000 8,923,000 8,859,000 
      general and administrative
    19,378,000 18,847,000 16,389,000 14,580,000 13,503,000 10,955,000 9,741,000 10,394,000 8,212,000 7,069,000 7,863,000 7,075,000 6,300,000 5,752,000 6,667,000 5,554,000 5,923,000 5,221,000 5,186,000 4,828,000 4,816,000 3,800,000 3,938,000 3,994,000 3,452,000 2,778,000 2,700,000 2,376,000 
      total operating expenses
    115,104,000 105,446,000 99,382,000 88,806,000 84,389,000 151,138,000 66,893,000 64,927,000 51,017,000 45,839,000 41,564,000 36,253,000 34,159,000 30,465,000 29,039,000 28,350,000 25,579,000 21,331,000 20,689,000 19,807,000 16,382,000 15,851,000 13,963,000 12,590,000 12,478,000 11,319,000 11,623,000 11,235,000 
      income from operations
    -108,544,000 -94,570,000 108,452,000 -88,806,000 -84,389,000 -144,138,000 -66,893,000 -64,927,000 -51,017,000 -41,917,000 -33,526,000 -32,709,000 -26,279,000 -26,443,000 660,000 -22,499,000 -14,220,000 -18,369,000 -11,713,000 -11,051,000 -9,135,000 -5,280,000 -4,996,000 -12,590,000 -12,478,000 -11,319,000 -11,623,000 -11,235,000 
      yoy
    28.62% -34.39% -262.13% 36.78% 65.41% 243.87% 99.53% 98.50% 94.14% 58.52% -5179.70% 45.38% 84.80% 43.95% -105.63% 103.59% 55.67% 247.90% 134.45% -12.22% -26.79% -53.35% -57.02% 12.06%     
      qoq
    14.78% -187.20% -222.12% 5.23% -41.45% 115.48% 3.03% 27.27% 21.71% 25.03% 2.50% 24.47% -0.62% -4106.52% -102.93% 58.22% -22.59% 56.83% 5.99% 20.97% 73.01% 5.68% -60.32% 0.90% 10.24% -2.62% 3.45%  
      operating margin %
    -1654.63% -869.53% 52.18% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% -1068.77% -417.09% -922.94% -333.49% -657.46% 2.22% -384.53% -125.19% -Infinity% -Infinity% -Infinity% -Infinity% -49.95% -55.72% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      other income
                             2,000  6,000 
      interest income and other income
    10,005,000 11,297,000 10,792,000 11,315,000 12,211,000 13,826,000 15,072,000 12,155,000 11,445,000 7,962,000 6,086,000 4,783,000 2,639,000 2,242,000 955,000 443,000 207,000 157,000 131,000 104,000 114,000 145,000 70,000 199,000 435,000    
      net income
    -98,539,000 -83,273,000 119,244,000 -77,491,000 -72,178,000 -130,312,000 -51,821,000 -52,772,000 -39,572,000 -33,955,000 -27,440,000 -27,926,000 -23,640,000 -24,201,000 1,615,000 -22,056,000 -14,013,000 -18,212,000 -11,582,000 -10,947,000 -9,021,000 -5,135,000 -4,926,000 -12,391,000 -12,043,000 -10,781,000 -10,969,000 -10,656,000 
      yoy
    36.52% -36.10% -330.11% 46.84% 82.40% 283.78% 88.85% 88.97% 67.39% 40.30% -1799.07% 26.61% 68.70% 32.88% -113.94% 101.48% 55.34% 254.66% 135.12% -11.65% -25.09% -52.37% -55.09% 16.28%     
      qoq
    18.33% -169.83% -253.88% 7.36% -44.61% 151.47% -1.80% 33.36% 16.54% 23.74% -1.74% 18.13% -2.32% -1598.51% -107.32% 57.40% -23.06% 57.24% 5.80% 21.35% 75.68% 4.24% -60.25% 2.89% 11.71% -1.71% 2.94%  
      net income margin %
    -1502.12% -765.66% 57.37% -Infinity% -Infinity% -Infinity% NaN% NaN% NaN% -865.76% -341.38% -787.98% -300.00% -601.72% 5.44% -376.96% -123.36% -Infinity% -Infinity% -Infinity% -Infinity% -48.58% -54.93% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      unrealized gains on marketable securities
    -2,761,000 215,000 531,000 -64,000 773,000 -3,024,000 5,252,000 -493,000 -1,485,000 1,312,000 429,000 226,000                 
      comprehensive loss
    -101,300,000   -77,555,000 -71,405,000 -133,336,000 -46,569,000 -53,265,000 -41,057,000   -27,700,000 -22,174,000   -22,881,000 -16,105,000 -18,874,000 -11,628,000 -10,950,000 -9,028,000 -5,163,000 -4,948,000 -12,334,000 -12,108,000 -10,794,000 -10,928,000 -10,627,000 
      net loss per common share, basic and diluted
    -1,110   -880 -820 -1,550 -600 -680 -530   -500 -490   -570 -360 -490 -310 -330 -280 -140 -170 -590 -590    
      weighted-average common shares outstanding, basic and diluted
    88,699,754,000   88,472,197,000 88,356,335,000  86,188,510,000 77,962,730,000 75,108,484,000                    
      comprehensive income
     -7,296,250 119,775,000       -19,221,250 -27,011,000   -9,436,000 1,242,000              
      net income per common share, basic
     -85 1,350       -360 -460   -220 40              
      weighted-average common shares outstanding, basic
      88,526,781,000                          
      net income per common share, diluted
     -85 1,330       -0.36 -0.46   -0.22 0.04              
      weighted-average common shares outstanding, diluted
      89,690,878,000                          
      weighted-average number of common shares outstanding used in computing net loss per share, basic
              59,999,449                  
      weighted-average number of common shares outstanding used in computing net loss per share, diluted
              59,999,449                  
      weighted-average number of common shares outstanding used in computing net loss per share, basic and diluted
     88,485,238    81,678,069    57,519,929  56,251,130 48,370,074 41,444,696  38,660,971 38,591,966 35,252,443 37,769,910 32,854,926 31,761,207 24,721,775 28,396,670 21,001,730 20,250,549    
      unrealized losses on marketable securities
                1,466,000 1,131,000 -373,000 -825,000 -2,092,000            
      weighted-average number of common shares outstanding used in computing net income (loss) per share, basic
                  40,301,568              
      weighted-average number of common shares outstanding used in computing net income (loss) per share, diluted
                  41,109,571              
      change in unrealized losses on marketable securities
                     -14,250 -46,000 -3,000 -7,000        
      change in unrealized gains on marketable securities
                         -28,000 -22,000 57,000 -65,000 27,250 41,000 29,000 
      interest income
                             536,000 654,000 573,000 
      net income per share
                             -0.21 -0.54 -1.3 
      weighted-average number of shares outstanding, basic and diluted
                              20,158,223 8,218,010 
                                
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 
                                 
        assets
                                 
        current assets
                                 
        cash and cash equivalents
      112,825,000 298,927,000 114,645,000 129,996,000 84,378,000 400,283,000 183,049,000 108,345,000 157,018,000 151,850,000 102,843,000 67,237,000 68,632,000 101,954,000 49,106,000 55,291,000 92,046,000 108,428,000 90,427,000 136,752,000 72,037,000 81,238,000 147,543,000 35,462,000 34,067,000 38,848,000 88,115,000 
        short-term marketable securities
      526,563,000 487,967,000 555,093,000 562,512,000 591,941,000 519,746,000 518,609,000 590,427,000 368,096,000 316,901,000 390,873,000 272,233,000 296,197,000 284,290,000 219,514,000 197,308,000 154,724,000 156,123,000 183,749,000 165,569,000 211,548,000 197,445,000 22,871,000 52,401,000 64,889,000 70,508,000 32,048,000 
        prepaid expenses and other current assets
      21,366,000 15,761,000 15,864,000 15,364,000 13,391,000 12,165,000 11,520,000 10,566,000 7,500,000 6,728,000 7,912,000 4,020,000 5,414,000 3,744,000 3,281,000 2,753,000 3,123,000 3,394,000 4,288,000 2,915,000 3,143,000 2,654,000 3,536,000 1,601,000 2,698,000 2,805,000 2,469,000 
        contract assets
      5,973,000                           
        total current assets
      666,727,000 802,655,000 685,602,000 707,872,000 689,713,000 932,214,000 713,179,000 709,353,000 532,632,000 482,182,000 501,788,000 343,958,000 370,454,000 393,437,000 272,189,000 256,049,000 250,996,000 268,963,000 279,789,000 308,158,000 288,605,000 281,337,000 173,950,000 89,464,000 101,654,000 112,161,000 122,632,000 
        restricted cash
      1,015,000 805,000 805,000 805,000 805,000 911,000 911,000 757,000 757,000 722,000 722,000 106,000 106,000 106,000 106,000 106,000 106,000 106,000 106,000 106,000 106,000 106,000 106,000 106,000 106,000 106,000 106,000 
        long-term marketable securities
      410,297,000 349,960,000 322,131,000 358,665,000 405,832,000 280,128,000 251,071,000 242,636,000 107,492,000 42,394,000 16,377,000 11,740,000 8,317,000 7,691,000 55,171,000 93,628,000 121,293,000 121,217,000 38,254,000 8,080,000  10,158,000 1,545,000 3,040,000 1,526,000   
        property and equipment
      8,217,000 8,172,000 8,819,000 8,871,000 8,966,000 8,235,000 7,122,000 6,909,000 6,164,000 6,192,000 6,829,000 6,716,000 6,509,000 6,679,000 7,163,000 5,274,000 4,763,000 4,707,000 4,898,000 4,755,000 4,271,000 4,095,000 4,289,000 4,337,000 4,642,000 4,767,000 5,050,000 
        right-of-use assets
      23,068,000 23,544,000 23,913,000 24,428,000 18,775,000 18,385,000 1,305,000 1,780,000 2,246,000 1,347,000 1,733,000 2,112,000 2,484,000 2,848,000 3,204,000 3,554,000 3,898,000 4,234,000 4,563,000 4,887,000 5,205,000 5,515,000 4,594,000 4,828,000 5,057,000 5,279,000 5,545,000 
        total assets
      1,109,324,000 1,185,136,000 1,041,270,000 1,100,641,000 1,124,091,000 1,239,873,000 973,663,000 961,527,000 649,316,000 532,942,000 527,557,000 364,746,000 387,969,000 410,907,000 338,007,000 358,867,000 381,347,000 399,444,000 328,401,000 326,097,000 298,269,000 301,384,000 184,510,000 101,791,000 113,001,000 122,331,000 133,358,000 
        liabilities and stockholders’ equity
                                 
        current liabilities
                                 
        accounts payable
      17,584,000 18,433,000 17,270,000 17,631,000 15,421,000 12,567,000 15,886,000 6,290,000 6,598,000 5,169,000 5,868,000 4,376,000 4,280,000 3,645,000 4,227,000 3,364,000 2,100,000 2,152,000 2,108,000 1,281,000 953,000 1,405,000 952,000 684,000 709,000 763,000 1,080,000 
        accrued liabilities
      40,892,000 45,258,000 37,750,000 32,907,000 30,352,000 28,092,000 24,250,000 17,519,000 18,756,000 16,188,000 14,690,000 17,274,000 16,999,000 16,988,000 16,230,000 12,628,000 12,320,000 11,892,000 9,910,000 7,756,000 8,516,000 6,390,000 5,223,000 5,429,000 5,023,000 3,992,000 4,077,000 
        operating lease liabilities, current
      339,000 328,000 318,000 308,000 298,000  606,000 1,151,000 1,747,000    1,871,000    1,699,000    1,540,000       
        total current liabilities
      58,815,000 64,509,000 55,338,000 50,846,000 46,071,000 40,659,000 40,742,000 24,960,000 27,101,000 24,893,000 25,337,000 29,820,000 31,718,000 32,727,000 58,089,000 56,957,000 45,159,000 38,637,000 35,771,000 36,129,000 38,640,000 54,173,000 7,426,000 7,346,000 6,940,000 5,947,000 6,473,000 
        long-term operating lease liabilities
      27,575,000 26,917,000 26,279,000 25,660,000 18,873,000 18,796,000 1,263,000 1,256,000 1,125,000  611,000 1,116,000 1,611,000 2,097,000 2,572,000 3,031,000 3,482,000    5,183,000       
        total liabilities
      86,390,000 93,102,000 81,617,000 76,506,000 64,944,000 59,455,000 42,005,000 26,216,000 28,226,000 24,893,000 25,948,000 30,936,000 38,514,000 42,138,000 68,686,000 70,200,000 79,833,000 81,815,000 88,141,000 92,971,000 99,995,000 105,955,000 12,452,000 12,688,000 12,601,000 11,925,000 12,750,000 
        commitments and contingencies
                                 
        stockholders’ equity
                                 
        preferred stock, 0.0001 par value...
                                 
        common stock, 0.0001 par value...
      9,000 9,000 9,000 9,000 9,000 9,000 8,000 7,000 7,000 6,000 6,000 5,000 5,000 5,000 4,000 4,000 4,000 4,000 3,000 3,000 3,000 3,000 3,000 2,000 2,000 2,000 2,000 
        additional paid-in capital
      1,757,197,000 1,743,239,000 1,730,633,000 1,717,560,000 1,681,167,000 1,669,102,000 1,373,774,000 1,324,163,000 968,885,000 823,202,000 789,751,000 594,253,000 587,724,000 583,968,000 485,763,000 482,228,000 478,970,000 476,211,000 387,215,000 369,130,000 325,250,000 317,242,000 288,923,000 193,635,000 192,824,000 192,036,000 191,310,000 
        accumulated other comprehensive income
      2,267,000 2,052,000 1,521,000 1,585,000 812,000 3,836,000 -1,416,000 -923,000 562,000        -712,000 -50,000 -4,000  7,000 35,000 57,000  65,000 78,000 37,000 
        accumulated deficit
      -736,539,000 -653,266,000 -772,510,000 -695,019,000 -622,841,000 -492,529,000 -440,708,000 -387,936,000 -348,364,000 -314,409,000 -286,969,000 -259,043,000 -235,403,000 -211,202,000 -212,817,000 -190,761,000 -176,748,000 -158,536,000 -146,954,000 -136,007,000 -126,986,000 -121,851,000 -116,925,000 -104,534,000 -92,491,000 -81,710,000 -70,741,000 
        total stockholders’ equity
      1,022,934,000 1,092,034,000 959,653,000 1,024,135,000 1,059,147,000 1,180,418,000 931,658,000 935,311,000 621,090,000 508,049,000 501,609,000 333,810,000 349,455,000 368,769,000 269,321,000 288,667,000 301,514,000 317,629,000 240,260,000 233,126,000 198,274,000 195,429,000 172,058,000 89,103,000 100,400,000 110,406,000 120,608,000 
        total liabilities and stockholders’ equity
      1,109,324,000 1,185,136,000 1,041,270,000 1,100,641,000 1,124,091,000 1,239,873,000 973,663,000 961,527,000 649,316,000 532,942,000 527,557,000 364,746,000 387,969,000 410,907,000 338,007,000 358,867,000 381,347,000 399,444,000 328,401,000 326,097,000 298,269,000 301,384,000 184,510,000 101,791,000    
        contract liabilities, current
       490,000                          
        long-term contract liabilities
       1,676,000                          
        accounts receivable
          3,000 20,000 1,000 15,000 18,000 6,703,000 160,000 468,000 211,000 3,449,000 288,000 697,000 1,103,000 1,018,000 1,325,000 2,922,000 1,877,000       
        other non-current assets
            75,000 92,000 25,000 105,000 108,000 114,000 99,000 146,000 174,000 256,000 291,000 217,000 791,000 111,000 82,000 173,000 26,000 16,000 16,000 18,000 25,000 
        contract liability
               1,439,000 2,818,000 6,255,000 8,568,000 10,267,000 35,849,000 39,224,000 29,040,000 22,935,000 22,132,000 25,508,000 27,613,000 44,847,000      
        long-term contract liability
                  5,185,000 7,314,000 8,025,000 10,212,000 31,192,000 39,248,000 48,008,000 52,063,000 56,160,000 46,186,000      
        operating lease liabilities - current
               2,097,000 1,961,000 1,915,000  1,827,000 1,783,000 1,741,000            
        accumulated other comprehensive loss
               -750,000 -1,179,000 -1,405,000 -2,871,000 -4,002,000 -3,629,000 -2,804,000            
        other current liabilities
                        3,000 6,000 18,000 29,000 45,000 57,000 63,000 76,000 89,000 
        other non-current liabilities
                       6,000 6,000 6,000 12,000 12,000 16,000 21,000 34,000 52,000 60,000 
        lease liabilities
                       1,658,000 1,618,000 1,578,000  1,502,000 1,206,000 1,176,000 1,145,000 1,116,000 1,227,000 
        long-term lease liabilities
                       3,924,000 4,356,000 4,773,000  5,584,000 5,010,000 5,321,000 5,627,000 5,926,000 6,217,000 
        deferred offering costs
                                 
        liabilities, redeemable convertible preferred stock and stockholders’ equity
                                 
        deferred rent
                                 
        series a redeemable convertible preferred stock, 0.0001 par value...
                                 
        series b redeemable convertible preferred stock, 0.0001 par value...
                                 
        total liabilities, redeemable convertible preferred stock and stockholders’ equity
                              113,001,000 122,331,000 133,358,000 
        stockholder’s equity
                                 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 
                                  
          cash flows from operating activities
                                  
          net loss
        -83,273,000 119,244,000 -77,491,000 -72,178,000 -130,312,000 -51,821,000 -52,772,000 -39,572,000 -33,955,000 -27,440,000 -27,926,000 -23,640,000 -24,201,000 1,615,000 -22,056,000 -14,013,000 -18,212,000 -11,582,000 -10,947,000 -9,021,000 -5,135,000 -4,926,000 -12,391,000 -12,043,000 -10,781,000 -10,969,000 
          adjustments to reconcile net loss to net cash from operating activities
                                  
          depreciation and amortization
        721,000 661,000 718,000 600,000 572,000 577,000 622,000 616,000 629,000 640,000 619,000 588,000 558,000 569,000 510,000 464,000 448,000 451,000 444,000 382,000 361,000 347,000 337,000 336,000 330,000 324,000 
          net amortization of premiums on marketable securities
            -4,916,000 -5,363,000 -6,640,000 -6,314,000 -3,876,000 -3,566,000 -2,554,000 -1,557,000 -1,127,000 -86,000 169,000 349,000 469,000 466,000 445,000 454,000       
          stock-based compensation
        11,793,000 12,217,000 11,868,000 10,237,000 9,485,000 9,215,000 9,734,000 6,312,000 4,798,000 5,301,000 4,731,000 3,659,000 2,975,000 3,005,000 3,044,000 2,605,000 2,064,000 2,197,000 2,058,000 1,918,000 1,046,000 981,000 824,000 758,000 719,000 518,000 
          amortization of right of use assets
                                  
          changes in assets and liabilities
                                  
          accounts receivable
            17,000 -19,000 14,000 3,000 6,685,000 -6,543,000 308,000 -257,000 3,238,000 -3,161,000 409,000 406,000 -85,000 307,000 1,597,000 -1,045,000       
          prepaid expenses and other assets
        -5,562,000 192,000 -500,000 -1,970,000 -1,736,000 -934,000 -371,000 -3,133,000 -724,000 1,187,000 -3,881,000 1,373,000 -1,627,000 -441,000 -451,000 400,000 206,000 1,324,000 -1,918,000 199,000 -429,000 767,000 -1,945,000 1,097,000 108,000 -328,000 
          accounts payable
        -858,000 1,191,000 -364,000 2,728,000 2,976,000 -3,939,000 9,696,000 -453,000 1,745,000 -699,000 1,601,000 -12,000 397,000 -449,000 1,053,000 863,000 -7,000 377,000 536,000 260,000 -459,000 493,000 227,000 -36,000 -42,000 36,000 
          accrued and other liabilities
        -4,799,000 7,508,000 4,843,000 2,875,000 2,274,000 2,895,000 6,898,000 -1,273,000 2,481,000 2,414,000 -2,841,000 -419,000 323,000 1,150,000 2,959,000 140,000 476,000 2,012,000 2,339,000 -615,000 1,806,000 1,437,000 -635,000 384,000 1,030,000 55,000 
          contract assets and liabilities
                                  
          lease liabilities
        669,000 648,000 629,000 611,000 -86,000 -280,000 -538,000 -465,000 -487,000 -475,000 -459,000 -451,000 -442,000 -431,000 -417,000 -409,000 -401,000 -392,000 -377,000 -372,000 -363,000 870,000 -281,000 -275,000 -270,000 -402,000 
          net cash from operating activities
        -90,496,000 142,214,000 -62,474,000 -60,342,000 -121,655,000 -49,234,000 -32,882,000 -43,813,000 -23,748,000 -30,174,000 -33,460,000 -27,842,000 -23,370,000 -24,166,000 -19,992,000 -19,647,000 -16,657,000 -12,468,000 -12,930,000 -13,724,000 -11,596,000 90,210,000 -13,606,000 -9,545,000 -8,706,000 -10,550,000 
          capital expenditures
        100,000 -70,000 -660,000 -676,000 -901,000 776,000 -1,111,000 -1,142,000 -838,000 -603,000 -1,030,000 703,000 -1,101,000 -1,470,000 149,000 -699,000 -650,000 -583,000 -620,000 180,000 -337,000 220,000  -216,000 -113,000 
          free cash flows
        -90,396,000 142,144,000 -63,134,000 -61,018,000 -122,556,000 -48,458,000 -33,993,000 -44,955,000 -24,586,000 -30,777,000 -34,490,000 -27,139,000 -23,370,000 -25,267,000 -21,462,000 -19,498,000 -17,356,000 -13,118,000 -13,513,000 -14,344,000 -11,416,000 89,873,000 -13,386,000  -8,922,000 -10,663,000 
          cash flows from investing activities
                                  
          purchases of property and equipment
        -333,000 -42,000 -663,000 -1,330,000 -1,102,000 -457,000 -973,000 -1,325,000 -838,000 -603,000 -884,000 -43,000 -1,101,000 -1,941,000 -401,000 -605,000 -458,000 -578,000 -1,003,000 -179,000 -245,000   -216,000 -82,000 
          purchases of marketable securities
        -236,138,000 -138,991,000 -127,553,000 -105,207,000 -337,041,000 -213,724,000 -164,763,000 -475,781,000 -221,605,000 -81,832,000 -220,247,000 -72,296,000 -65,501,000 -88,085,000 -37,922,000 -64,300,000 -32,568,000 -149,382,000 -94,308,000 -38,738,000 -27,902,000 -188,166,000 -14,993,000 -11,253,000 -1,887,000 -47,659,000 
          maturities of marketable securities
        138,945,000 180,800,000 174,134,000 186,354,000 141,034,000 194,145,000 234,293,000 123,135,000 110,500,000 133,782,000 99,750,000 95,860,000 55,225,000 70,503,000 53,179,000 46,940,000 32,760,000 93,533,000 41,487,000 76,176,000 23,527,000 4,828,000 46,050,000 22,159,000 5,990,000 49,444,000 
          net cash from investing activities
        -97,526,000 41,767,000 45,918,000 79,817,000 -197,109,000 -20,036,000 68,557,000 -353,971,000 -111,943,000 51,347,000 -121,381,000 23,521,000 -10,276,000 -18,683,000 13,316,000 -17,761,000 -413,000 -56,307,000 -49,381,000 36,435,000 -4,554,000 -183,583,000 30,988,000 10,906,000 3,887,000 -38,441,000 
          cash flows from financing activities
                                  
          proceeds from issuance of common stock in public offering, net of issuance costs
                                  
          proceeds from issuances of pre-funded warrants
                                  
          proceeds from issuance of common stock related to at-the-market offering program, net of issuance costs
        -46,000 -83,000 -25,000 25,009,000 -65,000 -27,000 36,321,000 343,650,000 -156,000 26,228,000 -34,000 2,560,000 -138,000 9,070,000 -66,000 -9,000 -23,000 -22,000 15,416,000 41,892,000       
          proceeds from exercise of common stock options
        1,503,000 384,000 410,000 1,134,000 2,500,000 2,441,000 2,081,000 5,461,000  1,855,000              34,000 38,000 184,000 
          proceeds from espp purchases
                                  
          net cash from financing activities
        2,130,000 301,000 1,205,000 26,143,000 2,753,000 286,504,000 39,183,000 349,111,000 140,894,000 27,834,000 191,063,000 2,926,000 324,000 95,697,000 491,000 653,000 688,000 86,776,000 15,986,000 42,004,000 6,949,000 27,068,000 94,699,000 34,000 38,000 -276,000 
          net increase in cash, cash equivalents and restricted cash
        -185,892,000 184,282,000 -15,351,000 45,618,000 -316,011,000 217,234,000   5,203,000 49,007,000   -33,322,000 52,848,000   -16,382,000 18,001,000 -46,325,000 64,715,000 -9,201,000 -66,305,000 112,081,000 1,395,000 -4,781,000 -49,267,000 
          cash, cash equivalents and restricted cash
        -185,892,000 184,282,000 -15,351,000 130,801,000 -316,011,000 217,234,000 74,858,000 109,102,000 5,203,000 49,007,000 36,222,000 67,343,000 -33,322,000 52,848,000 -6,185,000 55,397,000 -16,382,000 18,001,000 -46,325,000 136,858,000 -9,201,000 -66,305,000 112,081,000 35,568,000 -4,781,000 -49,267,000 
          cash, cash equivalents and restricted cash, at beginning of period
        85,183,000 157,775,000 68,738,000 92,152,000 72,143,000 34,173,000 
          cash, cash equivalents and restricted cash, at end of period
        -185,892,000 184,282,000 -15,351,000 130,801,000 -316,011,000 217,234,000 74,858,000 109,102,000 5,203,000 49,007,000 36,222,000 67,343,000 -33,322,000 52,848,000 -6,185,000 55,397,000 -16,382,000 18,001,000 -46,325,000 136,858,000 -9,201,000 -66,305,000 112,081,000 35,568,000 -4,781,000 -49,267,000 
          reconciliation of cash, cash equivalents and restricted cash
                                  
          cash and cash equivalents
        -186,102,000 184,282,000 -15,351,000 129,996,000 -315,905,000 217,234,000 74,704,000 108,345,000 5,168,000 49,007,000 35,606,000 67,237,000 -33,322,000 52,848,000 -6,185,000 55,291,000 -16,382,000 18,001,000 -46,325,000 136,752,000 -9,201,000 -66,305,000 112,081,000 35,462,000 -4,781,000 -49,267,000 
          restricted cash
        210,000 805,000 -106,000 154,000 757,000 35,000 616,000 106,000 106,000 106,000 106,000 
          supplemental disclosure of cash flow information:
                                  
          cash paid for interest
            3,000 10,000 12,000 32,000 11,000 13,000 13,000 14,000 14,000 16,000 16,000 16,000 18,000 18,000 19,000 20,000 20,000 21,000 21,000 22,000 45,000 
          supplemental non-cash investing and financing activities:
                                  
          right-of-use asset obtained in exchange for a new operating lease liability
        6,186,000 461,000                      
          purchases of property and equipment in accounts payable and accrued liabilities
        433,000 -28,000 3,000 654,000 201,000 1,233,000 -138,000 183,000   -146,000 746,000   471,000 550,000 -94,000 -192,000 -5,000 383,000 359,000 -92,000 220,000 33,000  -31,000 
          unpaid offering costs
                8,000 -316,000 295,000 56,000 -457,000      111,000 60,000       
          net accretion of discounts on marketable securities
         -1,982,000 -2,692,000 -3,778,000                       
          amortization of right-of-use assets
         369,000 515,000 533,000  435,000 475,000 466,000  386,000 379,000 372,000  356,000             
          contract liabilities
                -1,439,000 -1,379,000 -3,437,000 -7,498,000 -3,828,000 -26,293,000 -5,562,000 -10,796,000 -1,951,000 -7,957,000 -7,431,000 -6,202,000 -7,260,000      
          proceeds from issuance of common stock upon public offering, net of issuance costs
                 -249,000            6,789,000     
          proceeds from issuance of pre-funded warrants to purchase common stock, net of issuance costs
                                 
          proceeds from espp purchase
                  -349,000           
          unpaid at-the-market offering program costs
            -3,000                     
          net decrease in cash, cash equivalents and restricted cash
               -48,673,000    -1,395,000               
          accrued atm costs
               145,000                   
          sales of marketable securities
                              -40,144,000 
          proceeds from exercise of common stock options, net of repurchases
                   366,000 517,000 496,000 -227,000 662,000 341,000 808,000 243,000 112,000 173,000 291,000     
          cash paid for income taxes
                          1,000 
          vesting of early exercised options and restricted stock
                        1,000 2,000 3,000 18,000 12,000 13,000 15,000 16,000 26,000 17,000 
          loss on sale of property and equipment
                            2,000 11,000 
          realized gain on marketable securities
                                 
          right-of-use assets
                       344,000 336,000 329,000 324,000 318,000 311,000 -921,000 233,000 229,000 223,000 266,000 
          proceeds from issuance of common stock in private placement, net of issuance costs
                                 
          right-of-use asset obtained in exchange for new operating lease liability
                                  
          net incresae (decrease) in cash, cash equivalents and restricted cash
                       -36,755,000           
          conversion of redeemable convertible preferred stock into common stock
                                
          issuance of series b redeemable convertible preferred stock pursuant to license agreement
                                  
          change in fair value of redeemable convertible preferred stock liability
                                  
          landlord contributions for leasehold improvements
                                  
          gain on sale of marketable securities
                                  
          deferred rent
                                  
          proceeds from issuance of redeemable convertible preferred stock, net of issuance costs
                                  
          payments of deferred offering costs
                                  
          unpaid deferred offering costs
                                  
          extinguishment of redeemable convertible preferred stock liability
                                  
          net amortization of premiums and discounts on marketable securities
                             129,000 26,000 5,000  -61,000 
          gain on sales of marketable securities
                               -2,000  
          proceeds from issuance of common stock in initial public offering, net of issuance costs
                                 
          leasehold improvements acquired through tenant improvement allowance
                                  
          proceeds from issuance of initial public offering, net of issuance costs