Quarterly
Annual
| Unit: USD | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
assets | ||||||||||||||||||||||||||
current assets | ||||||||||||||||||||||||||
cash and cash equivalents | 298,927,000 | 114,645,000 | 129,996,000 | 84,378,000 | 400,283,000 | 183,049,000 | 108,345,000 | 157,018,000 | 151,850,000 | 102,843,000 | 67,237,000 | 68,632,000 | 101,954,000 | 49,106,000 | 55,291,000 | 92,046,000 | 108,428,000 | 90,427,000 | 136,752,000 | 72,037,000 | 81,238,000 | 147,543,000 | 35,462,000 | 34,067,000 | 38,848,000 | 88,115,000 |
short-term marketable securities | 487,967,000 | 555,093,000 | 562,512,000 | 591,941,000 | 519,746,000 | 518,609,000 | 590,427,000 | 368,096,000 | 316,901,000 | 390,873,000 | 272,233,000 | 296,197,000 | 284,290,000 | 219,514,000 | 197,308,000 | 154,724,000 | 156,123,000 | 183,749,000 | 165,569,000 | 211,548,000 | 197,445,000 | 22,871,000 | 52,401,000 | 64,889,000 | 70,508,000 | 32,048,000 |
prepaid expenses and other current assets | 15,761,000 | 15,864,000 | 15,364,000 | 13,391,000 | 12,165,000 | 11,520,000 | 10,566,000 | 7,500,000 | 6,728,000 | 7,912,000 | 4,020,000 | 5,414,000 | 3,744,000 | 3,281,000 | 2,753,000 | 3,123,000 | 3,394,000 | 4,288,000 | 2,915,000 | 3,143,000 | 2,654,000 | 3,536,000 | 1,601,000 | 2,698,000 | 2,805,000 | 2,469,000 |
total current assets | 802,655,000 | 685,602,000 | 707,872,000 | 689,713,000 | 932,214,000 | 713,179,000 | 709,353,000 | 532,632,000 | 482,182,000 | 501,788,000 | 343,958,000 | 370,454,000 | 393,437,000 | 272,189,000 | 256,049,000 | 250,996,000 | 268,963,000 | 279,789,000 | 308,158,000 | 288,605,000 | 281,337,000 | 173,950,000 | 89,464,000 | 101,654,000 | 112,161,000 | 122,632,000 |
restricted cash | 805,000 | 805,000 | 805,000 | 805,000 | 911,000 | 911,000 | 757,000 | 757,000 | 722,000 | 722,000 | 106,000 | 106,000 | 106,000 | 106,000 | 106,000 | 106,000 | 106,000 | 106,000 | 106,000 | 106,000 | 106,000 | 106,000 | 106,000 | 106,000 | 106,000 | 106,000 |
long-term marketable securities | 349,960,000 | 322,131,000 | 358,665,000 | 405,832,000 | 280,128,000 | 251,071,000 | 242,636,000 | 107,492,000 | 42,394,000 | 16,377,000 | 11,740,000 | 8,317,000 | 7,691,000 | 55,171,000 | 93,628,000 | 121,293,000 | 121,217,000 | 38,254,000 | 8,080,000 | 10,158,000 | 1,545,000 | 3,040,000 | 1,526,000 | |||
property and equipment | 8,172,000 | 8,819,000 | 8,871,000 | 8,966,000 | 8,235,000 | 7,122,000 | 6,909,000 | 6,164,000 | 6,192,000 | 6,829,000 | 6,716,000 | 6,509,000 | 6,679,000 | 7,163,000 | 5,274,000 | 4,763,000 | 4,707,000 | 4,898,000 | 4,755,000 | 4,271,000 | 4,095,000 | 4,289,000 | 4,337,000 | 4,642,000 | 4,767,000 | 5,050,000 |
right-of-use assets | 23,544,000 | 23,913,000 | 24,428,000 | 18,775,000 | 18,385,000 | 1,305,000 | 1,780,000 | 2,246,000 | 1,347,000 | 1,733,000 | 2,112,000 | 2,484,000 | 2,848,000 | 3,204,000 | 3,554,000 | 3,898,000 | 4,234,000 | 4,563,000 | 4,887,000 | 5,205,000 | 5,515,000 | 4,594,000 | 4,828,000 | 5,057,000 | 5,279,000 | 5,545,000 |
total assets | 1,185,136,000 | 1,041,270,000 | 1,100,641,000 | 1,124,091,000 | 1,239,873,000 | 973,663,000 | 961,527,000 | 649,316,000 | 532,942,000 | 527,557,000 | 364,746,000 | 387,969,000 | 410,907,000 | 338,007,000 | 358,867,000 | 381,347,000 | 399,444,000 | 328,401,000 | 326,097,000 | 298,269,000 | 301,384,000 | 184,510,000 | 101,791,000 | 113,001,000 | 122,331,000 | 133,358,000 |
liabilities and stockholders’ equity | ||||||||||||||||||||||||||
current liabilities | ||||||||||||||||||||||||||
accounts payable | 18,433,000 | 17,270,000 | 17,631,000 | 15,421,000 | 12,567,000 | 15,886,000 | 6,290,000 | 6,598,000 | 5,169,000 | 5,868,000 | 4,376,000 | 4,280,000 | 3,645,000 | 4,227,000 | 3,364,000 | 2,100,000 | 2,152,000 | 2,108,000 | 1,281,000 | 953,000 | 1,405,000 | 952,000 | 684,000 | 709,000 | 763,000 | 1,080,000 |
accrued liabilities | 45,258,000 | 37,750,000 | 32,907,000 | 30,352,000 | 28,092,000 | 24,250,000 | 17,519,000 | 18,756,000 | 16,188,000 | 14,690,000 | 17,274,000 | 16,999,000 | 16,988,000 | 16,230,000 | 12,628,000 | 12,320,000 | 11,892,000 | 9,910,000 | 7,756,000 | 8,516,000 | 6,390,000 | 5,223,000 | 5,429,000 | 5,023,000 | 3,992,000 | 4,077,000 |
contract liabilities, current | 490,000 | |||||||||||||||||||||||||
operating lease liabilities, current | 328,000 | 318,000 | 308,000 | 298,000 | 606,000 | 1,151,000 | 1,747,000 | 1,871,000 | 1,699,000 | 1,540,000 | ||||||||||||||||
total current liabilities | 64,509,000 | 55,338,000 | 50,846,000 | 46,071,000 | 40,659,000 | 40,742,000 | 24,960,000 | 27,101,000 | 24,893,000 | 25,337,000 | 29,820,000 | 31,718,000 | 32,727,000 | 58,089,000 | 56,957,000 | 45,159,000 | 38,637,000 | 35,771,000 | 36,129,000 | 38,640,000 | 54,173,000 | 7,426,000 | 7,346,000 | 6,940,000 | 5,947,000 | 6,473,000 |
long-term contract liabilities | 1,676,000 | |||||||||||||||||||||||||
long-term operating lease liabilities | 26,917,000 | 26,279,000 | 25,660,000 | 18,873,000 | 18,796,000 | 1,263,000 | 1,256,000 | 1,125,000 | 611,000 | 1,116,000 | 1,611,000 | 2,097,000 | 2,572,000 | 3,031,000 | 3,482,000 | 5,183,000 | ||||||||||
total liabilities | 93,102,000 | 81,617,000 | 76,506,000 | 64,944,000 | 59,455,000 | 42,005,000 | 26,216,000 | 28,226,000 | 24,893,000 | 25,948,000 | 30,936,000 | 38,514,000 | 42,138,000 | 68,686,000 | 70,200,000 | 79,833,000 | 81,815,000 | 88,141,000 | 92,971,000 | 99,995,000 | 105,955,000 | 12,452,000 | 12,688,000 | 12,601,000 | 11,925,000 | 12,750,000 |
commitments and contingencies | ||||||||||||||||||||||||||
stockholders’ equity | ||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of september 30, 2025 and december 31, 2024; no shares issued and outstanding as of september 30, 2025 and december 31, 2024 | ||||||||||||||||||||||||||
common stock | 9,000 | 9,000 | 9,000 | 9,000 | 9,000 | 8,000 | 7,000 | 7,000 | 6,000 | 6,000 | 5,000 | 5,000 | 5,000 | 4,000 | 4,000 | 4,000 | 4,000 | 3,000 | 3,000 | 3,000 | 3,000 | 3,000 | 2,000 | 2,000 | 2,000 | 2,000 |
additional paid-in capital | 1,743,239,000 | 1,730,633,000 | 1,717,560,000 | 1,681,167,000 | 1,669,102,000 | 1,373,774,000 | 1,324,163,000 | 968,885,000 | 823,202,000 | 789,751,000 | 594,253,000 | 587,724,000 | 583,968,000 | 485,763,000 | 482,228,000 | 478,970,000 | 476,211,000 | 387,215,000 | 369,130,000 | 325,250,000 | 317,242,000 | 288,923,000 | 193,635,000 | 192,824,000 | 192,036,000 | 191,310,000 |
accumulated other comprehensive income | 2,052,000 | 1,521,000 | 1,585,000 | 812,000 | 3,836,000 | -1,416,000 | -923,000 | 562,000 | -712,000 | -50,000 | -4,000 | 7,000 | 35,000 | 57,000 | 65,000 | 78,000 | 37,000 | |||||||||
accumulated deficit | -653,266,000 | -772,510,000 | -695,019,000 | -622,841,000 | -492,529,000 | -440,708,000 | -387,936,000 | -348,364,000 | -314,409,000 | -286,969,000 | -259,043,000 | -235,403,000 | -211,202,000 | -212,817,000 | -190,761,000 | -176,748,000 | -158,536,000 | -146,954,000 | -136,007,000 | -126,986,000 | -121,851,000 | -116,925,000 | -104,534,000 | -92,491,000 | -81,710,000 | -70,741,000 |
total stockholders’ equity | 1,092,034,000 | 959,653,000 | 1,024,135,000 | 1,059,147,000 | 1,180,418,000 | 931,658,000 | 935,311,000 | 621,090,000 | 508,049,000 | 501,609,000 | 333,810,000 | 349,455,000 | 368,769,000 | 269,321,000 | 288,667,000 | 301,514,000 | 317,629,000 | 240,260,000 | 233,126,000 | 198,274,000 | 195,429,000 | 172,058,000 | 89,103,000 | 100,400,000 | 110,406,000 | 120,608,000 |
total liabilities and stockholders’ equity | 1,185,136,000 | 1,041,270,000 | 1,100,641,000 | 1,124,091,000 | 1,239,873,000 | 973,663,000 | 961,527,000 | 649,316,000 | 532,942,000 | 527,557,000 | 364,746,000 | 387,969,000 | 410,907,000 | 338,007,000 | 358,867,000 | 381,347,000 | 399,444,000 | 328,401,000 | 326,097,000 | 298,269,000 | 301,384,000 | 184,510,000 | 101,791,000 | |||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of june 30, 2025 and december 31, 2024; no shares issued and outstanding as of june 30, 2025 and december 31, 2024 | ||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of march 31, 2025 and december 31, 2024; no shares issued and outstanding as of march 31, 2025 and december 31, 2024 | ||||||||||||||||||||||||||
accounts receivable | 3,000 | 20,000 | 1,000 | 15,000 | 18,000 | 6,703,000 | 160,000 | 468,000 | 211,000 | 3,449,000 | 288,000 | 697,000 | 1,103,000 | 1,018,000 | 1,325,000 | 2,922,000 | 1,877,000 | |||||||||
other non-current assets | 75,000 | 92,000 | 25,000 | 105,000 | 108,000 | 114,000 | 99,000 | 146,000 | 174,000 | 256,000 | 291,000 | 217,000 | 791,000 | 111,000 | 82,000 | 173,000 | 26,000 | 16,000 | 16,000 | 18,000 | 25,000 | |||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of december 31, 2024 and december 31, 2023; no shares issued and outstanding as of december 31, 2024 and december 31, 2023 | ||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of september 30, 2024 and december 31, 2023; no shares issued and outstanding as of september 30, 2024 and december 31, 2023 | ||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of june 30, 2024 and december 31, 2023; no shares issued and outstanding as of june 30, 2024 and december 31, 2023 | ||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of march 31, 2024 and december 31, 2023; no shares issued and outstanding as of march 31, 2024 and december 31, 2023 | ||||||||||||||||||||||||||
contract liability | 1,439,000 | 2,818,000 | 6,255,000 | 8,568,000 | 10,267,000 | 35,849,000 | 39,224,000 | 29,040,000 | 22,935,000 | 22,132,000 | 25,508,000 | 27,613,000 | 44,847,000 | |||||||||||||
long-term contract liability | 5,185,000 | 7,314,000 | 8,025,000 | 10,212,000 | 31,192,000 | 39,248,000 | 48,008,000 | 52,063,000 | 56,160,000 | 46,186,000 | ||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of december 31, 2023 and december 31, 2022; no shares issued and outstanding as of december 31, 2023 and december 31, 2022 | ||||||||||||||||||||||||||
operating lease liabilities - current | 2,097,000 | 1,961,000 | 1,915,000 | 1,827,000 | 1,783,000 | 1,741,000 | ||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of september 30, 2023 and december 31, 2022; no shares issued and outstanding as of september 30, 2023 and december 31, 2022 | ||||||||||||||||||||||||||
accumulated other comprehensive loss | -750,000 | -1,179,000 | -1,405,000 | -2,871,000 | -4,002,000 | -3,629,000 | -2,804,000 | |||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of june 30, 2023 and december 31, 2022; no shares issued and outstanding as of june 30, 2023 and december 31, 2022 | ||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of march 31, 2023 and december 31, 2022; no shares issued and outstanding as of march 31, 2023 and december 31, 2022 | ||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of december 31, 2022 and december 31, 2021; no shares issued and outstanding as of december 31, 2022 and december 31, 2021 | ||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of september 30, 2022 and december 31, 2021; no shares issued and outstanding as of september 30, 2022 and december 31, 2021 | ||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of june 30, 2022 and december 31, 2021; no shares issued and outstanding as of june 30, 2022 and december 31, 2021 | ||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of march 31, 2022 and december 31, 2021; no shares issued and outstanding as of march 31, 2022 and december 31, 2021 | ||||||||||||||||||||||||||
other current liabilities | 3,000 | 6,000 | 18,000 | 29,000 | 45,000 | 57,000 | 63,000 | 76,000 | 89,000 | |||||||||||||||||
other non-current liabilities | 6,000 | 6,000 | 6,000 | 12,000 | 12,000 | 16,000 | 21,000 | 34,000 | 52,000 | 60,000 | ||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of december 31, 2021 and december 31, 2020; no shares issued and outstanding as of december 31, 2021 and december 31, 2020 | ||||||||||||||||||||||||||
lease liabilities | 1,658,000 | 1,618,000 | 1,578,000 | 1,502,000 | 1,206,000 | 1,176,000 | 1,145,000 | 1,116,000 | 1,227,000 | |||||||||||||||||
long-term lease liabilities | 3,924,000 | 4,356,000 | 4,773,000 | 5,584,000 | 5,010,000 | 5,321,000 | 5,627,000 | 5,926,000 | 6,217,000 | |||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of september 30, 2021 and december 31, 2020; no shares issued and outstanding as of september 30, 2021 and december 31, 2020 | ||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of june 30, 2021 and december 31, 2020; no shares issued and outstanding as of june 30, 2021 and december 31, 2020 | ||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of march 31,2021 and december 31, 2020; no shares issued and outstanding as of march 31, 2021 and december 31, 2020 | ||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of december 31, 2020 and december 31, 2019; no shares issued and outstanding as of december 31, 2020 and december 31, 2019 | ||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of september 30, 2020 and december 31, 2019; no shares issued and outstanding as of september 30, 2020 and december 31, 2019 | ||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of june 30, 2020 and december 31, 2019; no shares issued and outstanding as of june 30, 2020 and december 31, 2019 | ||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of march 31, 2020 and december 31, 2019; no shares issued and outstanding as of march 31, 2020 and december 31, 2019 | ||||||||||||||||||||||||||
deferred offering costs | ||||||||||||||||||||||||||
liabilities, redeemable convertible preferred stock and stockholders’ equity | ||||||||||||||||||||||||||
deferred rent | ||||||||||||||||||||||||||
series a redeemable convertible preferred stock, 0.0001 par value, no shares authorized as of december 31, 2019 and 59,433,105 shares authorized as of december 31, 2018; no shares issued and outstanding as of december 31, 2019 and 5,794,727 shares issued and outstanding as of december 31, 2018; liquidation value of 0 as of december 31, 2019 and 47,178 as of december 31, 2018 | ||||||||||||||||||||||||||
series b redeemable convertible preferred stock, 0.0001 par value, no shares authorized as of december 31, 2019 and 75,500,000 shares authorized as of december 31, 2018; no shares issued and outstanding as of december 31, 2019 and 7,345,067 shares issued and outstanding as of december 31, 2018; liquidation value of 0 as of december 31, 2019 and 97,520 as of december 31, 2018 | ||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of december 31, 2019 and no shares authorized as of december 31, 2018; no shares issued and outstanding as of december 31, 2019 and december 31, 2018 | ||||||||||||||||||||||||||
total liabilities, redeemable convertible preferred stock and stockholders’ equity | 113,001,000 | 122,331,000 | 133,358,000 | |||||||||||||||||||||||
series a redeemable convertible preferred stock, 0.0001 par value, no shares authorized as of september 30, 2019 and 59,433,105 shares authorized as of december 31, 2018; no shares issued and outstanding as of september 30, 2019 and 5,794,727 shares issued and outstanding as of december 31, 2018; liquidation value of 0 as of september 30, 2019 and 47,178 as of december 31, 2018 | ||||||||||||||||||||||||||
series b redeemable convertible preferred stock, 0.0001 par value, no shares authorized as of september 30, 2019 and 75,500,000 shares authorized as of december 31, 2018; no shares issued and outstanding as of september 30, 2019 and 7,345,067 shares issued and outstanding as of december 31, 2018; liquidation value of 0 as of september 30, 2019 and 97,520 as of december 31, 2018 | ||||||||||||||||||||||||||
stockholder’s equity | ||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of september 30, 2019 and no shares authorized as of december 31, 2018; no shares issued and outstanding as of september 30, 2019 and december 31, 2018 | ||||||||||||||||||||||||||
series a redeemable convertible preferred stock, 0.0001 par value, no shares authorized as of june 30, 2019 and 59,433,105 shares authorized as of december 31, 2018; no shares issued and outstanding as of june 30, 2019 and 5,794,727 shares issued and outstanding as of december 31, 2018; liquidation value of 0 as of june 30, 2019 and 47,178 as of december 31, 2018 | ||||||||||||||||||||||||||
series b redeemable convertible preferred stock, 0.0001 par value, no shares authorized as of june 30, 2019 and 75,500,000 shares authorized as of december 31, 2018; no shares issued and outstanding as of june 30, 2019 and 7,345,067 shares issued and outstanding as of december 31, 2018; liquidation value of 0 as of june 30, 2019 and 97,520 as of december 31, 2018 | ||||||||||||||||||||||||||
preferred stock, 0.0001 par value, 10,000,000 shares authorized as of june 30, 2019 and no shares authorized as of december 31, 2018; no shares issued and outstanding as of june 30, 2019 and december 31, 2018 |
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